A framework for managing timetable data quality within the NMMU
- Authors: Els, Dierdre Jean
- Date: 2008
- Subjects: Computer algorithms Timetables , Management information systems , Management -- Data processing , Information storage and retrieval systems -- Management , Information management
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:9769 , http://hdl.handle.net/10948/948 , Computer algorithms Timetables , Management information systems , Management -- Data processing , Information storage and retrieval systems -- Management , Information management
- Description: This dissertation investigates the influencing factors on timetable quality, not only from a data quality perspective, but also from an information quality perspective which takes into account the quality of the business processes involved in creating the timetable. The Nelson Mandela Metropolitan University was used as a case study for assessing the quality of the timetable process, the quality of the source data, and the quality of the final timetable produced. A framework for managing the data quality during the timetabling process is proposed. The framework is based on reviews done on data quality management best practices and data quality aspects. Chapter 1 introduces the current Nelson Mandela Metropolitan University timetable, and motivates why data quality management is essential to its success. The scope and research objectives are presented for this dissertation. Chapter 2 covers a literature study on business process and data quality management best practices. The common thread through all the management methodologies investigated, was top management involvement and commitment to continuously improving the quality of data. Chapter 3 discusses various characteristics of data quality. Quality is determined to be whether the end result meets the quality requirements for which it was intended. Hence each system could have quality aspects that are unique to it. Chapter 4 explains various research designs and which were followed for this dissertation. The combination of literature studies, a questionnaire and a case study were used. Chapter 5 is a case study of the data quality and timetabling processes used at the Nelson Mandela Metropolitan University and is based on the research design described in chapter 4. The current business processes followed in setting up the current timetable are presented, as well as the proposed timetabling process that should produce a better quality timetable for the Nelson Mandela Metropolitan 4 University. The data quality aspects most pertinent to the Nelson Mandela Metropolitan University are determined, being timeliness, accountability, integrity and consistency, as well as the most probable causes for bad timetable quality, like uniform technology, processes, ownership and using a common terminology. Chapter 6 presents a framework for managing timetable data quality at the Nelson Mandela Metropolitan University using an Information Product Map approach that will ensure a better quality timetable. Future research is also proposed. It is evident from this dissertation that data quality of source data as well as the quality of the business process involved is essential for producing a timetable that satisfies the requirements for which it was intended. The management framework proposed for the Nelson Mandela Metropolitan University timetabling process can potentially be used at other institutions as well.
- Full Text:
- Date Issued: 2008
Evaluation of the pharmaceutical availability of erythromycin from topical formulations
- Authors: Mandimika, Nyaradzo
- Date: 2008
- Subjects: Pharmacy -- Research Chromatographic analysis Gel permeation chromatography Gels (Pharmacy) Chemistry, analytic Acne -- Treatment Sebaceous glands -- Diseases -- Treatment Drugs -- Testing Erythromycin -- Bioavailability
- Language: English
- Type: Thesis , Masters , MPharm
- Identifier: vital:3771 , http://hdl.handle.net/10962/d1003249
- Description: Erythromycin (ERY) is a macrolide antibiotic which is used in the treatment of acne vulgaris.Acne is a common skin condition that occurs when the sebaceous glands and hair shafts become infected by the bacteria Propionibacterium acnes. Acne is a chronic condition that may last for years and the severity of the effects of the disease on patients is often undermined especially in third world countries where more emphasis is placed on other more life-threatening diseases. It may cause considerable physical and emotional distress to sufferers along with the possibility of permanent scarring. Although use of topical ERY formulations is not the first line of treatment it has proven to be effective in treating inflammation of skin and skin structures cause by the responsible bacteria. To-date there are a variety of vehicles which are used in preparing topical ERY formulations namely ointment and gel bases, alcoholic solutions and pledgets. All the gel formulations on the market contain hydroxypropyl cellulose, alcohol and water along with the active ingredient(s). However, some gel formulations contain propylene glycol in addition to these excipients an example being Emgel®. Propylene glycol has been shown to affect the penetration of topically applied drugs through the skin suggesting that it would be highly likely that those formulations which contain propylene glycol may release more ERY into the skin following application. With this in mind, two ERY gel formulations were produced which contained different percentages of propylene glycol. According to the FDA guidelines, pharmacokinetic measurements in blood, plasma and/or urine of topical dermatological drug products are not feasible to document bioequivalence since the active ingredient(s) in topical formulations is/are not intended to be absorbed into the systemic circulation and in addition, concentrations in extracutaneous biological tissues would generally not be measurable. This limits determination of bioavailability and assessment of bioequivalence of such products to pharmacodynamic measurements, clinical trials and dermatopharmacokinetic (DPK) measurements such as tape stripping (TS) and microdialysis (MD).TS is a sampling technique which involves sequential removal of layers of the stratum corneum using strips of adhesive tape. This technique has found increasing use in DPK studies for investigation of drug kinetics in the skin following the application of a topical formulation. The technique has also been used as a diagnostic tool in assessing the quality of the stratum corneum in diseased skin. In the current research study, the tape stripping technique was used to investigate the pharmaceutical/biological availability of topical gel formulations containing ERY. MD is another DPK sampling technique which has been used to determine the amount of a topically applied drug that penetrates through the stratum corneum to reach deeper tissues of the skin. The in vivo sampling technique involves the insertion of microdialysis probes beneath the skin surface in the dermal tissue and allows for real-time sampling of the analyte at its target site. Recently in vitro MD has also been successfully used to assess the pharmaceutical availability of a topical corticosteroid, mometesone furoate, from topical formulations. Based on this work, microdialysis was used to determine the pharmaceutical availability of ERY from gel formulations which were developed for use in this research. The results of the pharmaceutical availability of ERY from in vivo tape stripping studies and the in vitro microdialysis studies were compared to establish correlation between the data. Pharmaceutical equivalence and bioequivalence data obtained from the respective studies on the gel formulations were investigated by statistical analysis of the data generated from both the in vitro and in vivo experiments. In summary the objectives of this research were: 1. To develop and validate a high performance liquid chromatography method suitable to analyse ERY concentrations obtained from in vitro microdialysis studies and in vivo tape stripping studies. 2. To prepare two different ERY gel formulations with different percentage content of propylene glycol. 3. To determine the pharmaceutical availability of ERY from two different gel formulations using in vitro microdialysis. 4. To develop and validate a tape stripping technique which could be used to determine percutaneous penetration and bioequivalence of the gel formulations. 5. To compare in vitro microdialysis and in vivo tape stripping data and attempt to establish a correlation between the two different approaches.
- Full Text:
- Date Issued: 2008