An exploration of corporate social responsibility in SME liquor retail outlets in Buffalo City Metropolitan Municipality, Eastern Cape
- Authors: Mupazi, Rutendo Getrude
- Date: 2013
- Subjects: Small business -- South Africa -- Eastern Cape , Retail trade -- South Africa -- Eastern Cape , Liquor industry -- South Africa -- Eastern Cape , Social responsibility of business -- South Africa -- Eastern Cape , Liquor laws -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , M Com (Business Management)
- Identifier: http://hdl.handle.net/10353/799 , vital:26498 , Small business -- South Africa -- Eastern Cape , Retail trade -- South Africa -- Eastern Cape , Liquor industry -- South Africa -- Eastern Cape , Social responsibility of business -- South Africa -- Eastern Cape , Liquor laws -- South Africa -- Eastern Cape
- Description: In the contemporary business environment, a plethora of retail literature exists which examine the influence of CSR on the business. However, literature that explores Corporate Social Responsibility (CSR) in the liquor retail sector has been relatively sparse. This study explored CSR in Small to Medium Enterprise (SME) liquor retail outlets in the Buffalo City Metropolitan Municipality, Eastern Cape, South Africa. The objectives of the study were to investigate the engagement of SME liquor retailers in CSR practices, to ascertain whether a relationship exists between providing employee training on responsible retailing of alcohol and CSR practices by SME liquor retailers, to investigate whether employee involvement in decision making influences CSR practices by SME liquor retailers, to ascertain whether a relationship exists between the practical actions to reduce alcohol-related harm and CSR practices by SME liquor retailers, to investigate whether SME liquor retailers do social good as an expression of CSR as well as to determine whether SME liquor retailers are influenced by stakeholders to engage in CSR initiatives. Both primary and secondary data sources were used in this study. A quantitative research design was used in conducting this research. Convenience sampling, a non-probability sampling technique, was used to select a sample of 94 from the sample frame of 123 SME liquor retailers. The survey method, by way of a self-administered questionnaire was used to collect primary data. The statistical Package for Social Sciences (SPSS) as statistical software was used to analyse data. The Chi-square test, Pearson correlation, and descriptive statistics were used to analyse data. The findings of this research revealed that Stakeholder influence, employee involvement in decision making and employee training in responsible retailing of alcohol have an influence on the CSR practices of SME liquor retailers. The study also identified the safety and practical measures that SME liquor retailers are practicing as a way of reducing alcohol related-harm. A recommendation to stakeholders, such as suppliers and government to find more strategies of influencing SME liquor retailers to practice CSR, was made. Lastly, recommendations were made to SME liquor owners and managers on how to improve their CSR practices.
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- Date Issued: 2013
The screening and characterisation of compounds for modulators of heat shock protein (Hsp90) in a breast cancer cell model
- Authors: Moyo, Buhle
- Date: 2013 , 2013-07-18
- Subjects: Heat shock proteins Breast -- Cancer Breast -- Cancer -- Chemotherapy Breast -- Cancer -- Treatment Cancer cells Naphthoquinone PQQ (Biochemistry)
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4060 , http://hdl.handle.net/10962/d1004129
- Description: Breast cancer is a leading cause of cancer death in Africa. Hsp90 has been identified as a target for anti-cancer treatments as its inhibition results in the disruption and ubiquitin–proteasome degradation of activated oncoproteins. Currently, there are no US Food and Drug Administration approved Hsp90 inhibitor drugs and existing Hsp90 inhibitors such as geldanamycin and novobiocin are hepatotoxic and display a low affinity for Hsp90, respectively. Therefore, there is a need for the development of Hsp90 inhibitors with improved inhibitory properties. In this study twelve natural compounds bearing a quinone nucleus were screened and characterised for the modulation of Hsp90. The compounds analysed formed three series; the sargaquinoic acid (SQA), naphthoquinone, and pyrroloiminoquinone alkaloid series. Certain compounds exhibited half maximal inhibitory concentrations of between 3.32 μM and 12.4 μM, while others showed no antiproliferative activity at concentrations of up to 500 μM in the MDA-MB-231 breast adenocarcinoma cell line. Immunofluorescence and Western analyses indicated that the modulation of Hsp90 and partner proteins by SQA was more similar to that of novobiocin. Isothermal titration calorimetry analyses suggested that SQA interacted with Hsp90β with a low affinity, and saturation-transfer difference nuclear magnetic resonance confirmed that this interaction with Hsp90β occurred through the methyl moiety bound to 1, 4 benzoquinone of SQA. Pulldown assays indicated SQA disrupted the association between Hsp90 and Hop dose-dependently, more similarly to novobiocin. Immunofluorescence and Western analyses performed on naphthoquinone and pyrroloiminoquinone alkaloid compounds indicated modulation of Hsp90 and Hsp90 partner proteins by the compounds. Naphthoquinone compounds were prioritised for analysis for binding to Hsp90β over the pyrroloiminoquinone alkaloid compounds. Lapachol interacted with Hsp90β with a low affinity however; this interaction was thought to be too weak to disrupt the association of Hsp90 and Hop. The remaining naphthoquinone compounds showed no interaction with Hsp90β, thus allowing the determination of a preliminary structure-activity relationship for these compounds. To the best of our knowledge, this is the first study to describe a systematic subcellular analysis of the effects of geldanamycin and novobiocin in comparison to sargaquinoic acid and compounds of the naphthoquinone and pyrroloquinoline scaffold on Hsp90 and its partner proteins. , Microsoft� Word 2010 , Adobe Acrobat 9.54 Paper Capture Plug-in
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- Date Issued: 2013
Uphononongo ngokwesithako sobunzululwazi-sakhono kwiinoveli ezimbini zesiXhosa : (Ukhozi olunamaphiko noLwadilik' udonga)
- Authors: Jaxa, Nontembiso Patricia
- Date: 2013
- Subjects: Xhosa literature -- History and criticism , Xhosa language -- Grammar , Figures of speech
- Language: Xhosa
- Type: Thesis , Masters , MA
- Identifier: vital:8483 , http://hdl.handle.net/10948/d1020981
- Description: Kule ngxoxo kuqwalaselwa indlela ulwimi njengesakhono olusetyenziswe ngayo kwincwadi kaSaule, ethi, Ukhozi Olumaphiko kunye nobuchule bukaBongela ekubhaleni kwincwadi yakhe ethi, Lwadilik’ Udonga, yona eluguqulelo lwencwadi kaChinua Achebe, ethi, Things Fall Apart. Kule ngxoxo akuthelekiswa aba babhali babini koko kujongwe nje kunconywa ubuchule babo ekusebenziseni ulwimi ngendlela ephakamisa umgangatho weencwadi zabo. Oko, kudandalazisa ukubaluleka kokuqatshelwa kolwimi njengesakhono, ngababhali. Injongo yolu phando kukuba, ababhali bakuthathele ingqalelo ukubaluleka kokukhulisa nokukhuthaza ukusetyenziswa kolwimi ngokukubonisa oko kwiincwadi abazibhalileyo, ukuze, nakubafundi nootitshala ezikolweni, kube lula ukufunda nokufundisa ulwimi, kuphumezeke iinjongo zeNkcazelo yePolisi yeKharityhulam noHlolo (2011), yona ebethelela ukufundiswa kolwimi ngendlela ephucula nekhulisa umfundi kulwimi. Le ngxoxo ke ixhaswa ngezithako ngezithako zeengcali kwisakhono noguqulelo. Ingxoxo le yahlulwe yazizahluko ezihlanu. Isahluko sokuqala sivula ngentshayelelo, ze sidandalazise intsusamabandla yolu phando, kushukuxwe ingxubakaxaka elundululeyo, ze kwenziwe uphengululo lweencwadi zeengcali kwizithako zesakhono nezokuguqulela. Isahluko sesibini, siqwalasela indlela uSaule asebenzise ngayo iindidi zezivakalisi, kanti neendidi zezivakalisi ezidiza isakhono ngobuchule, ukuze kuphuhle amandla akhe ekubaliseni kuhlobo loncwadi alubhalileyo, nokuvakalisa iingcinga neengcamango zakhe, edlulisa nolwazi kwabo bafunda incwadi. Isahluko sesithathu, siyaqhuba nokusetyenziswa kolwimi njengesakhono sokubhala kwakwincwadi kaSaule, kodwa kujongwe ukusetyenziswa kwezifanekisozwi, izifaniso, uchongo-magama nentsingiselo kunye noburharha bombhali. Isahluko sesine sona sihlalutya isimbo sikaBongela ekubhaleni nasekuguquleleni kwincwadi yakhe ethi, Lwadilik’ udonga. Isahluko sesihlanu sesokuphetha, siyintyilazwi yeengxoxo ezikolu hlalutyo, kuxilongwa ubuzaza besithako sobunzululwazi-sakhono nokubaluleka kwaso ekuphuhliseni uncwadi jikelele. Ukusetyenziswa kolwimi kuko okungundoqo wokuphila koncwadi.
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- Date Issued: 2013