A history of Grahamstown, 1918-1945
- Authors: Torlesse, Ann Catherine Marjorie
- Date: 1993
- Subjects: Grahamstown (South Africa) -- History , Grahamstown (South Africa) -- Economic conditions
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2565 , http://hdl.handle.net/10962/d1002418 , Grahamstown (South Africa) -- History , Grahamstown (South Africa) -- Economic conditions
- Description: This study in local history describes socio-economic developments in Grahamstown between 1918 - 1945, and analyses the extent to which these developments mirrored trends in the macrocosm. During these years the city failed to become ndustrialised, but enhanced her reputation as an eminent educational centre. Despite being financially handicapped, the City Council undertook large public works schemes for the provision of essential services, such as electricity and an adequate supply of water. In addition a water-borne sewerage scheme was introduced, and roads were repaired and tarred. The influx of a large number of poor rural Blacks into the urban area placed a considerable strain on the city's health services, and housing projects had to be implemented. Local political affiliations and race relations are examined against the background of national developments, especially the growing entrenchment by the State of the policy of segregation. Attention is also devoted to the impact upon the community of international political crises. The cultural and sporting pursuits, as well as the entertainments enjoyed by Grahamstonians, are investigated; and a picture of the local "mentalite" is presented.
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- Date Issued: 1993
The application of rheological techniques in the characterization of semisolids in the pharmaceutical industry
- Authors: Jaganath, Nelesh
- Date: 2004
- Subjects: Drugs -- Dosage forms , Rheology
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10128 , http://hdl.handle.net/10948/380 , Drugs -- Dosage forms , Rheology
- Description: Rheological characterization of pharmaceutical semisolids is of importance as it provides fundamental information required for the assessment of some of the final properties of a product such as viscosity, elasticity, quality and storage stability. The effect of formulation variables on product characteristics such as consistency and correlation of consumer evaluation of consistency can also be attained. (Ramachandran et al., 1999) This study focussed on using rheological techniques to fully characterize the properties of various semisolid formulations being developed or produced at a South African-based generic pharmaceutical company. Various tests were employed to characterize the semisolid dosage forms (creams and ointments), including continuous shear tests such as flow and viscosity curves and yield point measurements, oscillatory tests such as amplitude and frequency sweeps, as well as step and temperature ramp tests. A method to determine justifiable and meaningful viscosity specifications was developed, where excellent reproducibility of results were obtained when compared to the single-point viscosity determinations usually used. An evaluation as to whether rheology can be utilized as an assessment tool for product stability revealed varying results, with the oscillation-frequency sweep test displaying modest predictive capabilities. Observable differences in rheological character were found when evaluating ointment formulations exhibiting deviating quality characteristics. When analysing the effect of varying processing parameters, namely, cooling rate and mixing speed, during the manufacture of a cream, statistically significant rheological differences were obtained, while a thorough characterization of a scale-up procedure was also achieved upon analysis of various rheological properties.
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- Date Issued: 2004