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An in-depth investigation of an early literacy intervention in Grade R in the Eastern Cape Province, South Africa

  • Authors: Hodgskiss, Jennifer Adelé
  • Date: 2023-03-29
  • Subjects: Uncatalogued
  • Language: English
  • Type: Academic theses , Doctoral theses , text
  • Identifier: http://hdl.handle.net/10962/366222 , vital:65844
  • Description: Thesis embargoed. Expected release date early 2025. , Thesis (PhD) -- Faculty of Education, Education, 2023
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  • Date Issued: 2023-03-29

The elucidation of nickel and zinc based Metal Organic Frameworks (MOFs) using a polycarboxylate-benzene ligand: a synthetic, spectroscopic, and thermoanalytical study

  • Authors: Hodgson, Ivan Mark
  • Date: 2022-04-06
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/290877 , vital:56795
  • Description: Thesis (MSc) -- Faculty of Science, Chemistry, 2022
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  • Date Issued: 2022-04-06

Analysis of the regulation of HSP90α expression upon differentiation of C2C12 cells

  • Authors: Holm, Nathan Christopher
  • Date: 2020
  • Subjects: Uncatalogued
  • Language: English
  • Type: thesis , text , Masters , MSc
  • Identifier: http://hdl.handle.net/10962/163318 , vital:41028
  • Description: Thesis (MSc)--Rhodes University, Faculty of Science, Biochemistry and Microbiology, 2020.
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  • Date Issued: 2020

Argyroploce Leucotreta: “The false Codlin moth”

  • Authors: Horne, H M R
  • Date: 1939
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/193375 , vital:45326
  • Description: This introduction and ensuing essay are something in the nature of a personal confession. Deemed as such what I have written concerning Samuel Palmer has not, in any way, been written as an exercise, but rather for the purpose of self-edification. This I will elaborate upon while disclosing my motive for writing on Palmer. Palmer's works - when I first saw them - were something of a revelation. They seemed the alpha and omega of my own artistic endeavour. Perhaps the term which best describes the euphoria I felt is 1deja vu1, because although it describes a connectedness of sorts, the words have in their sound an exotic ring. There is in it an implied equivocation - and equivocality best describes my understanding of Samuel Palmer at that juncture. This euphoria I felt dimmed with the realisation that by purportedly claiming, as I was, Samuel Palmer's visionary landscapes as my goal I was treading on sacred ground; I'd arrived, as it were, in another's Paradise. The effects of this upon my own creativity were completely negative. Worse still, I lacked the necessary means to extricate myself from Palmer's paradisiacal visions. His influence was incapacitating and convoluting my own growth. It was obvious then that I had to be rid of Samuel Palmer. , Thesis (MSc) -- Faculty of Science, Zoology and Entomology, 1939
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  • Date Issued: 1939

Country risk and stock market volatility in Africa: Measuring the contribution of political and economic risk factors

  • Authors: Hoveni, Jamela Basani
  • Date: 2022-10-14
  • Subjects: Uncatalogued
  • Language: English
  • Type: Academic theses , Doctoral theses , text
  • Identifier: http://hdl.handle.net/10962/405445 , vital:70172
  • Description: Thesis embargoed. To be released in 2025. , Thesis (PhD) -- Faculty of Commerce, Economics and economic History, 2022
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  • Date Issued: 2022-10-14

An appraisal analysis of a selection of Zapiro’s political cartoons

  • Authors: Hussey, Thomas Davey
  • Date: 2022-10-14
  • Subjects: Uncatalogued
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/406725 , vital:70302
  • Description: Thesis embargoed. To be released in 2025. , Thesis (MA) -- Faculty of Humanities, Linguistics and Applied Language Studies, 2022
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  • Date Issued: 2022-10-14

Abasebenzi basedokisini eKapa

  • Authors: ICU
  • Date: 1970
  • Subjects: Uncatalogued
  • Language: Xhosa
  • Type: text
  • Identifier: http://hdl.handle.net/10962/134467 , vital:37162
  • Description: Kule ncwadana sibalisa imbali ende yezitifido zaseKapa. Sibalisa ngezidube-dube zestifido noququzelo lwazo kwi ICU. Okulandelayo, sijonga ekukhuleni kwamandla ezitifido xa zaziququzelwa kumbutho we Cape Town Stevedoring ne Dock Workers Union. Emva Kwemfazwe Yesibini Yehlabathi sibona ubuthathaka bomanyano lwabasebenzi basedokisini kwiminyaka emininzi. Okokugqibela, sibalisa ibali labasebenzi bestifido, ukuzimanya kwabo nemibutho yabasebenzi nokukhula kwabo kwakhona ngowe 1970. , here put any information that you think is important but there is no field for it, if there isnt remove the field
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  • Date Issued: 1970

Stable Covalent pH-Sensitive Metallophthalocyanines Thin Monolayer Films for Selective Detection of Neurotransmitters

  • Authors: Idowu, Abosede Omowumi Atinuke
  • Date: 2021-10-29
  • Subjects: Uncatalogued
  • Language: English
  • Type: Doctoral theses , text
  • Identifier: http://hdl.handle.net/10962/192922 , vital:45279
  • Description: Thesis (PhD) -- Faculty of Humanities, Science, Chemistry, 2021
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  • Date Issued: 2021-10-29

Bioethical analysis of COVID19, WASH/waste and related disaster management implications

  • Authors: Iheanetu, Chidinma Uchenna
  • Date: 2022-04-06
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/232250 , vital:49975
  • Description: Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2022
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  • Date Issued: 2022-04-06

Inggs Undertakers: a brief history of the firm; and explanatory notes on the data captures from the diaries

  • Authors: Inggs Undertakers
  • Date: 20uu
  • Subjects: Uncatalogued
  • Language: English
  • Type: essays , text
  • Identifier: http://hdl.handle.net/10962/116283 , vital:34361 , Cory Library for Humanities Research
  • Description: A BRIEF HISTORY IF THE FIRM: Alexander Will, a Blacksmith of Aberdeen in Scotland, arrived in this country aboard the “Bermondsey” in November 1859. He was accompanied by his wife Sarah (nee Hay) and two small sons. The couple eventually had a family of 5 sons and 3 daughters. It is not known when the firm began but there is evidence that it was functioning in 1879 and may well have begun about 6 years prior to that. Unfortunately the diaries have only survived from 1900. Sarah died in 1914 and Alexander in March 1915. Their son, John Chalmers Will, then ran the firm until his death in 1952 when it passed to a relative, Oliver Douglas Inggs and became known as Inggs Undertakers. Oliver was known far and wide as “O.D.” and the locals knew the firm always as “Will’s Parlour” until the last of the generation that remembered the Will connection had passed on! O.D. ran the business and was an active participant in the daily affairs until his death on 30 June 1996 at the very advanced aged of 92 years. Still under the name of Inggs Undertakers it passed to the Wolmarans family – Mary Bowker (formerly Wolmarans) being a niece of O.D.’s and in 2004 is still being operated by Mary who is now a widow.
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  • Date Issued: 20uu

South African supratidal microbialites: prokaryote communities, metabolic capabilities, and biogeochemical processes

  • Authors: Isemonger, Eric William
  • Date: 2023-03-31
  • Subjects: Uncatalogued
  • Language: English
  • Type: Academic theses , Doctoral theses , text
  • Identifier: http://hdl.handle.net/10962/422641 , vital:71964
  • Description: Access restricted. Embargoed until 2025. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2023
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  • Date Issued: 2023-03-31

New Brighton

  • Authors: Jacobs, Lumkile , Zwane, Tinky
  • Date: 198-?
  • Subjects: Uncatalogued
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/113491 , vital:33790 , RHPC-001
  • Description: First from left in photo - L. Jacobs, third from left T. Zwane , Use of this resource is governed by the terms and conditions of the Creative Commons "Attribution-NonCommercial-ShareAlike" License (http://creativecommons.org/licenses/by-nc-sa/2.0/)
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  • Date Issued: 198-?

New Brighton

  • Authors: Jacobs, Lumkile , Zwane, Tinky
  • Date: 198-?
  • Subjects: Uncatalogued
  • Type: Image
  • Identifier: http://hdl.handle.net/10962/103573 , vital:32271 , RHPC-001
  • Description: First from left in photo - L. Jacobs, third from left T. Zwane , Use of this resource is governed by the terms and conditions of the Creative Commons "Attribution-NonCommercial-ShareAlike" License (http://creativecommons.org/licenses/by-nc-sa/2.0/)
  • Full Text: false
  • Date Issued: 198-?

Characterization of Trypanosoma brucei Sti1 and its interactions with Trypanosoma brucei Hsp83 and human Hsp90

  • Authors: Jamabo, Miebaka
  • Date: 2023-03-31
  • Subjects: Uncatalogued
  • Language: English
  • Type: Academic theses , Doctoral theses , text
  • Identifier: http://hdl.handle.net/10962/422629 , vital:71963 , DOI 10.21504/10962/422629
  • Description: Neglected tropical diseases continue to pose global concern due to their impact on health and socio-economic status of developing countries in sub-Saharan Africa. African trypanosomiasis is one of the neglected tropical diseases caused by the kinetoplastid flagellate parasite Trypanosoma brucei (T. brucei). The disease is fatal if untreated and the toolbox to combat the disease has been plagued with many difficulties such as drug resistance, toxic chemotherapeutics, and cumbersome drug delivery processes. In recent years, the disease has received attention from organizations such as the Drugs for Neglected Diseases initiative (DNDi) in partnership with WHO as well as academia and industry to provide alternatives to the existing drugs as part of a targeted approach to eliminate human African trypanosomiasis by 2030. The life cycle of the T. brucei parasite requires that it transitions between a cold-blooded vector (the tsetse fly) and a human host. To survive this extreme environmental change and maintain its infectious cycle, the parasite has evolved an arsenal of tools which include a strong immune evasion technique and a robust molecular chaperone system. Heat shock protein 90 (Hsp90) is one of the most abundant eukaryotic molecular chaperones that has been extensively studied in many organisms. It is indispensable for maintaining proteostasis in some organisms and its inhibition is currently being explored as a drug target for cancer and other parasitic diseases. In T. brucei, cytosolic Hsp90 is specifically referred to as Hsp83 due to variations in the sizes amongst different orthologues. Hsp90 is present in high levels in all stages of the T. brucei cell cycle both constitutively and on exposure to stress. To function in the cell, Hsp90 is dependent on co-chaperones, one of which can be found in most organisms, namely, the stress-inducible protein 1 (Sti1). The Hsp90-Sti1 interaction was shown to be crucial for growth in the intracellular kinetoplastid parasite, Leishmania donovani. However, this partnership has not been explored in the extracellular parasite T. brucei. To analyse the interaction of Hsp90 with Sti1 in T. brucei, this study combined in silico, in vitro and in vivo tools. In silico analyses of the Hsp90 complement in T. brucei revealed the presence of twelve putative Hsp90 genes, ten of which code for the cytosolic protein and are arranged in tandem in a head to tail fashion on the same chromosome. One gene each was found for the mitochondrial and ER paralogues of Hsp90, similar to all other species analysed. Eight putative co-chaperones specific to T. brucei were also discovered: six tetratricopeptide repeat domain (TPR) containing co-chaperones and two non-TPR containing co-chaperones. Structural and evolutionary analysis also confirmed that the domains were conserved across the species analysed. T. brucei Sti1 (TbSti1), T. brucei cytosolic Hsp90 (TbHsp83) and human cytosolic Hsp90 (hHsp90) were heterologously overproduced in E. coli and purified using nickel affinity chromatography. With specific antibodies, the expression and localization of the proteins were confirmed. TbSti1 showed strong affinity to the Hsp90s in the nanomolar range, with higher affinity for hHsp90 compared to TbHsp83. TbHsp83 and hHsp90 showed typical chaperone properties by suppressing the aggregation of thermolabile substrate MDH at equimolar concentrations and both chaperones had potent ATP hydrolysis activity. TbSti1, on the other hand, showed no MDH suppression activity and did not affect the ATP hydrolysis activity of TbHsp83 or hHsp90. Ex-vivo experiments using HeLa CRISPR Hop knockout (KO) human cell lines transfected with pcDNA3.1(+)HA-TbSti1 revealed TbSti1 also localized to the cytoplasm. The transfected cells showed a distinct fibroblast-like morphology which was different from the circular morphology seen in the Hop KO untransfected and wild type untransfected cells. Finally, co-immunoprecipitation studies revealed that TbSti1 co-immunoprecipitated with hHsp90. These results show the first characterization of the TbHsp83-TbSti1 partnership in T. brucei. The strong association between both proteins suggests a functional role for this partnership in T. brucei and could provide an updated context for understanding Trypanosome brucei biology. , Thesis (PhD) -- Faculty of Science, Biotechnology and Innovation Centre, 2023
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  • Date Issued: 2023-03-31

Biological longitudinal aspects of the Kabompo River, a significant tributary of the upper Zambezi sub-catchment, North-west Province, Zambia

  • Authors: Janse van Rensburg, Lomarie Cathleen
  • Date: 2023-03-29
  • Subjects: Uncatalogued
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/422292 , vital:71928
  • Description: The landscape of the Upper Zambezi Catchment in the remote North-Western Province of Zambia retains many natural features, but current and future anthropogenic activities threaten its integrity. Lack of information relating to the basic ecological functioning of the region hampers conservation efforts. Flooding from the adjacent woody-savanna and open grasslands in the Upper-Zambezi Catchment in the wet season drives crucial processes in the aquatic ecosystems such as the Kabompo River. This thesis describes aquatic food webs and describes the nutrient cycling in this river. A general introduction was based on the seasonality, river morphology, and biodiversity of the Kabompo River. There is no aquatic food web information available on this river. To address this knowledge gap, sampling of the principal food web components– vegetation, invertebrates, and fish – were collected in the dry season from August to September 2019 across six sites in the Kabompo River. Stable isotope analyses provided proxies for the food web structure at each site, and were the basis of longitudinal comparisons. The analyses suggest that the Kabompo River food webs follow the trophic ordination and nutrient cycling characteristic of the revised-Riverine Productivity Model. Food webs and community assemblages remain structurally similar between sites and provide some evidence of bottom-up productivity-driven trophic dynamics. To predict the possible landscape-scale processing of nutrient changes present for the aquatic ecosystems of the Kabompo River, a longitudinal comparison between a herbivore, Labeo cylindricus, and omnivore, Synodontis spp., fish species and their resources (primary producers and invertebrates) was done and showed archetypal fish food web trophic separation (2 ‰ to3 ‰) between species which remains consistent for the headwater sites. The nutrient values change at the convergence between the Kabompo Bridge and the Mwinilunga branches and show a decrease in the trophic separation of the sites below. This change becomes apparent from the last site, Watopa, where the trophic separation re-establishes (2 ‰ to 3 ‰) between the species. The trend suggests primarily autochthonous production in the headwater reaches, changing to allochthonous and autochthonous nutrient incorporation after the convergence of the two main branches. Permanent wetlands surrounding the convergence zones may be conducive to more primary producer activity and increased nutrient turnover. Permanent wetlands are a common feature of the Upper Zambezi Catchment tributaries, with the most notable lentic system the Barotse Flood Plains in the south, which shares reach-adjacent characteristics with the Kabompo River. Trends from the 2015 dry season identified for the Barotse Flood Plains support the findings of this thesis, where the δ13C values recorded reach depletion of -45 ‰. Management in the Upper Zambezi Basin and the Kabompo River comprises biannual assessments of water quality and quantity by the Zambezi River Authority, but not of the ecosystem process. This thesis may provide information to address the ecological (food webs and nutrient cycling) dynamics of the Basin rivers. As the first baseline information on the river's biology and ecology, it may present a comparative basis for future assessments under conservation management strategies. , Thesis (MSc) -- Faculty of Science, Ichthyology and Fisheries Science, 2023
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  • Date Issued: 2023-03-29

Islamic compliant short term insurance: an exploratory study to develop an Islamic compliant insurance model within a South African context

  • Authors: Jeeva, Shakir
  • Date: 2016
  • Subjects: Uncatalogued
  • Language: English
  • Type: Master's theses , text
  • Identifier: http://hdl.handle.net/10962/193633 , vital:45375
  • Description: In a world where there is ever increasing risks to be mitigated, either by choice or due to the law of the country, an insurance instrument is the most popular risk mitigation tool. However, from an Islamic perspective, Muslims have certain parameters to adhere to due to the laws and boundaries as set out in the Quraan, as well as the teachings of the final prophet, Prophet Muhammed (Peace Be Upon Him). This has relevance in this context as, according to Islam, the conventional insurance models are in contravention of certain Islamic laws as they contain elements which are not acceptable in the Muslim faith. Therefore, the Islamic insurance models, or Takaful models, have removed the impermissible elements of usury, speculation, and uncertainty, which are all contained in the current conventional insurance models. By removing these impermissible elements from the insurance model, the Takaful model is acceptable for Muslims to use as a risk mitigation tool. The primary aim of the study sought to propose a short term Islamic compliant insurance model within a South African framework. The secondary aims were to ascertain the Islamic requirements for an Islamic insurance model, how these requirements fit into an insurance model, to then compare and contrast the differences between conventional insurance and Islamic insurance and, lastly, to explore awareness and attitudes towards Islamic insurance. Therefore, from the above, a proposed short term Islamic insurance model was developed within a South African context which conforms to the laws and boundaries of Islam, making this insurance model permissible to use as a Takaful tool. Additionally, semi structured interviews were conducted with certain research participants, using purposive sampling, to examine the attitudes and knowledge of the Muslim community towards the Takaful model within a South African context. It was concluded that while the majority of the research participants understand the Takaful model and the significance of this, they have chosen to use the conventional insurance offerings due to the fact that they were unaware of other Takaful alternatives, or due to the fact that the Takaful alternative was out-priced when compared to the conventional insurance offerings. It was therefore concluded that while there is a need for Takaful offerings within South Africa, this must be done in conjunction with additional marketing, education and competitive pricing for potential clients to consider this as an insurance option. , Thesis (MCom) -- Faculty of Commerce, Accounting, 2016
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  • Date Issued: 2016

Source of introduced populations of Hemidactylus mabouia (Moreau de Jonnès, 1818) into the Eastern Cape Province and the potential spread to other South African regions

  • Authors: Jeme, Alungile
  • Date: 2023-03-29
  • Subjects: Uncatalogued
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/422334 , vital:71933
  • Description: Human movements globally have resulted in dispersal and introduction of terrestrial and marine organisms into areas outside of their native range. Species that have been introduced to new habitats can either be alien (not causing any harm to the new environment) or invasive alien species (destroying or competing with the indigenous species for resources). Investigating the source of these introductions is important as it provides baseline information about their biology and evolution. It also allows for better prevention measures for future invasions and for effective conservation strategies. In this study, I investigate the source of the introduced populations of tropical house geckos Hemidactylus mabouia in the Eastern Cape Province using two mitochondrial gene regions, ribosomal 16S and NADH dehydrogenase subunit 4 (ND4). We also look at the potential spread of these species using species distribution models (SDMs). The phylogeny showed that the introduced populations into the Eastern Cape were genetically similar to both H. mabouia lineages found in Central & Southern Africa. The phylogeny produced two clades from which the majority of the introduced samples were grouped in a clade with samples from Angola, DRC, and Mozambique, and only a few nested within the second clade with the South African native population. Haplotype networks from both genes also showed two clades, matching those found in the phylogeny. The introduced samples were associated with samples from Angola and those from South Africa (native) as these localities had a number of shared haplotypes. SDMs showed less evidence that these individuals could naturally move west down the coast as the probability of occurrence was below 0.4 from the Eastern Cape to the Western Cape. Our conclusion was that the introductions may be due to multiple avenues like species moving down the east coast or human translocation including trade routes. From this we can conclude that geckos are largely translocated through human movement as they are known for their opportunistic behaviours as they are commensal with humans. , Thesis (MSc) -- Faculty of Science, Zoology and Entomology, 2023
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  • Date Issued: 2023-03-29

An investigation of the correlation of mitochondrial biogenesis, mitochondrial DNA methylation, mitochondrial network topology and adipogenesis in the human adipose-derived mesenchymal stromal stem cell model

  • Authors: Kadye, Rose
  • Date: 2018
  • Subjects: Uncatalogued
  • Language: English
  • Type: text , Thesis , Doctoral , PhD
  • Identifier: http://hdl.handle.net/10962/62637 , vital:28222
  • Description: Expected release date-April 2019
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  • Date Issued: 2018

An evaluation of the cytotoxic activities of novel artemisinin derivatives: towards targeted therapies for triple-negative breast cancers (TNBC)

  • Authors: Kajewole, Deborah Ifeoluwa
  • Date: 2020
  • Subjects: Uncatalogued
  • Language: English
  • Type: thesis , text , Doctoral , PhD
  • Identifier: http://hdl.handle.net/10962/163329 , vital:41029 , doi:10.21504/10962/163329
  • Description: Thesis (PhD)--Rhodes University, Faculty of Science, Biochemistry and Microbiology, 2020.
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  • Date Issued: 2020

Optimization of an intranasal levodopa nanocrystalline formulation for delivery to the brain

  • Authors: Kakono, Chiedza
  • Date: 2023-03-29
  • Subjects: Uncatalogued
  • Language: English
  • Type: Academic theses , Master's theses , text
  • Identifier: http://hdl.handle.net/10962/420709 , vital:71771
  • Description: Thesis embargoed. Probable release date in 2025. , Thesis (MSc (Pharm)) -- Faculty of Pharmacy, Pharmacy, 2023
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  • Date Issued: 2023-03-29
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