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Gloria

Gloria

Gloria

Gloria in Excelsis

Glory, Hallelujah

Great Amen

Health and politics : appraisal and evaluation of the provision of health and mental health services for Blacks in South Africa

  • Authors: O'Donoghue, Sean B
  • Date: 1989
  • Subjects: Black people -- Mental health -- South Africa , Mental health services -- South Africa
  • Language: English
  • Type: text , Thesis , Masters , MA
  • Identifier: vital:2909 , http://hdl.handle.net/10962/d1002074
  • Description: The aim of this study has been to examine, in the light of recent events in the field of Health Care in South Africa, the remarks and claims made by the World Health Organization, and the American Psychiatric Association between 1976 and 1978 on Health Care services, as provided for Blacks, by the South African government. In two reports, these organizations instituted the earliest, and arguably most significant claims against South Africa's system of Health Care. This study sketches firstly the political genesis and social context of the WHO, and APA examinations. Secondly, this study evaluates responses made by the South African State to the critical climate inspired by the above mentioned reports, through a close analysis of recent events associated with the politics, and provision of Health Care Facilities - particularly with regard to Black South Africans. This analysis suggests that the governments' earlier tentative policy of privatisation (which was soundly condemned by WHO and the APA) has been even more enthusiastically pursued - in contradiction to it's avowed policies of Commu ity Health Care, and to the continuing detriment of those South African communities who are in most need of adequate Health Care services. The study concludes that the criticisms raised by the WHO and APA had the effect of inspiring positive reforms in South Africa's health services, but in no way thwarted the governments', at first only tentative plans, to increasingly privatise it's psychiatric and other medical institutions.
  • Full Text:
  • Date Issued: 1989

High-performance liquid chromatographic studies of the acid degradation, pharmacokinetics and comparative bioavailability of erythromycin

  • Authors: Glew, Fiona
  • Date: 1989
  • Subjects: High performance liquid chromatography , Erythromycin -- Analysis , Erythromycin -- Pharmacokinetics , Erythromycin -- Bioavailability
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:3737 , http://hdl.handle.net/10962/d1001529
  • Description: Erythromycin is a macrolide antibiotic with a spectrum similar to penicillin and is used mainly in the treatment of infections caused by gram-positive organisms. Since its discovery in 1952, erythromycin has achieved wide-spread clinical use. Susceptibility of erythromycin base to inactivation by acid results in decreased availability following exposure to acidic gastric fluids. Formulation of acid resistant dosage forms and the preparation of acid stable chemical derivatives have been attempted to improve absorption and subsequent clinical efficacy . Two of the most commonly used erythromycin derivatives are the stearic acid salt (erythromycin stearate) and the lauryl sulphate salt of the propionyl ester (erythromycin estolate). Although it has been known for many years that erythromycin is susceptible to acid degradation, very few reports on the stability of erythromycin in aqueous solutions appear in the literature. In this study, a high-performance liquid chromatographic system using electrochemical detection was employed for a kinetic study of erythromycin degradation. The effect of varying acid pH on the degradation rate of both erythromycin base and erythromycin stearate, and the effect on the hydrolysis rate of erythromycin estolate is presented. In addition, the effect of temperature on erythromycin degradation was also investigated. Until recently, the majority of pharmacokinetic and bioavailability studies have utilized relatively non-specific microbiological assay procedures. However, in this study a solid phase extraction, followed by the use of a high-performance liquid chromatographic system using electrochemical coulometric detection was employed for the determination of erythromycin in biological fluids. Human volunteers each received enteric coated erythromycin base pellets in capsule dosage form and also film coated erythromycin stearate tablets on separate occasions. Results from the clinical trials revealed the enteric coated erythromycin base pellets had a greater bioavailability than the film coated erythromycin stearate tablets. Computer fitting of data revealed no intra-volunteer variability in elimination rate constants, suggesting differences in serum levels following administration of both dosage forms are due to variation in absorption. Results from the clinical trials were also compared with those obtained from a further trial, during which the same volunteers received erythromycin estolate
  • Full Text:
  • Date Issued: 1989

Holy Communion Hymn

Hosi

Hosi hi twele vusiwana

Hosi hi twele vusiwana

I want to know, do you love my Lord?

Identification and analysis of manual materials handling tasks within a commercial warehouse in South Africa

  • Authors: Walraven, Lynne Louise
  • Date: 1989
  • Subjects: Materials handling -- Safety measures , Industrial safety -- South Africa , Lifting and carrying -- Safety measures
  • Language: English
  • Type: Thesis , Masters , MA
  • Identifier: vital:5159 , http://hdl.handle.net/10962/d1015722
  • Description: Lifting and overstraining are major causative factors related to musculoskeletal injuries and low back pain. A great number of work-related injuries arise from the handling and/or mishandling of materials. Hence there is a need to quantify risk factors in situ and develop guidelines for safe lifting practises in industry. The aim of this study was to make appropriate in situ quantification, within a commercial warehouse, of the stresses and physical demands imposed on the worker when performing two handed lifts in the sagittal plane. The performance of employees was assessed under normal working conditions through an observational methodology of data collection. Task performance evaluation was based on detailed measurement of all containers handled, an activity and time analysis, and the 'Work Practices Guide to Manual Lifting’ (NIOSH, 1981) which was used as the primary guide to developing theoretical recommendations to probable MMH risk factors for the workers involved. Of the 191 tasks analysed 103 were deemed unsuitable. Appropriate task factor adjustments were made where necessary to both the frequency and Hfactors (horizontal distance between the centre of gravity of the container and that of the worker) in order to reduce the risk factor for the workers
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  • Date Issued: 1989

Igazi Lemvana

Ilizwi le Nkosi

In vitro diffusion cell design and validation. I. A stability-indicating high-performance liquid chromatographic assay for betamethasone 17-valerate in purified isopropyl myristate receptor phase

  • Authors: Smith, Eric W , Haigh, John M
  • Date: 1989
  • Language: English
  • Type: text , Article
  • Identifier: vital:6431 , http://hdl.handle.net/10962/d1006595
  • Description: Introduction: The development of a reliable in vitro permeation system necessitates the use of a precise and accurate method of quantifying the amount of permeant partitioning from the membrane into the cell receptor phase. Aqueous donor and receptor chamber fluids have been used in the majority of reported investigations, which makes quantitative permeant analysis relatively facile. Alternatively, radiolabelled diffusants have been used and flux rates monitored by scintillation counting, obviating the need for chromatographic separation of the receptor-phase components. However, this technique is not applicable when nonlabelled compounds or commercial dosage forms are to be evaluated by a cell system. Furthermore, several studies indicate that aqueous receptor phases may not present an optimal partitioning environment for certain lipophilic permeants (1-4), thereby impairing accurate flux monitoring due to limited diffusant solubility. Several attempts have therefore been made to improve the partitioning environment within these systems, by the addition of surfactants for example (4). A lipophilic receptor environment appears beneficial for corticosteroid partitioning, and thus, the use of isopropyl myristate has been investigated because of its bipolar properties that tend to mimic the biochemical composition of the skin (5,6). Betamethasone 17-valerate and its 21-valerate degradation product are highly soluble in isopropyl myristate and this nonaqueous solvent will not augment C-17-to-C-21 ester degradation reactions.
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  • Date Issued: 1989

In vitro systems for the assessment of drug release from topical formulations and trans-membrane permeation

  • Authors: Smith, Eric W , Haigh, John M
  • Date: 1989
  • Language: English
  • Type: Book chapter
  • Identifier: vital:6441 , http://hdl.handle.net/10962/d1006628
  • Description: Numerous experimental methods have been developed to investigate drug release from vehicles and the percutaneous absorption of topically applied chemicals. The objective of this research is often to find correlation between laboratory results and the transdermal absorption experienced by living subjects so that in vivo experimentation may be curtailed. In many instances, the diverse experimental techniques tend to obscure absorption-controlling factors and complicate inter study comparisons, rather than clarify the complex transdermal absorption process. Moreover, lack of agreement between results may occasionally be ascribed to shortcomings in the in vitro methodology employed. The benefits of using an in vitro cell system for the preliminary testing of drug permeation in the laboratory are obvious. The environmental and diffusion variables may be controlled in an attempt to elucidate specific factors affecting the kinetic processes and drug bioavailability. Investigations are complex because of the multiple, interrelated events underlying the processes of drug partitioning from the applied vehicle and diffusion through the portals of the stratum corneum to the myriad of metabolic, binding, and clearance activities in the lower epidermal and dermal strata.
  • Full Text:
  • Date Issued: 1989

Interactions between ants, herbivorous insects and bracken (Pteridium aquilinum), a fern with extrafloral nectaries

  • Authors: Rashbrook, Vanessa Karin
  • Date: 1989
  • Subjects: Arthropod pests -- South Africa Ants -- South Africa Ferns -- South Africa
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:5592 , http://hdl.handle.net/10962/d1002042
  • Description: Bracken (Pteridium aquilinum) is a cosmopolitan species of fern which possesses extrafloral nectaries. A survey of the arthropod fauna associated with the plant throughout its range in South Africa identified the most widespread and damaging bracken herbivores and those species most likely to be influenced by ants visiting the extrafloral nectaries. Seventeen herbivorous arthropods were found to be definitely feeding on bracken and a further thirteen species with a less certain status were recorded. In addition, several species of ants were observed on the fronds and feeding at the extrafloral nectarie. On the basis of their widespread distribution and abundance, four bracken herbivores emerged as being particularly detrimental to the plant in South Africa. They were an eriophyid gall mite, a leafhopper and two moths. The biology of the two lepidopterans, Appana cinisigna and Panotima sp., suggested that they were potentially vulnerable to ants at various stages of their life histories. Laboratory experiments were undertaken to observe ant-lepidopteran interactions under controlled conditions. The ant Crematogaster peringueyi rapidly removed exposed A. cini igna eggs, but did not appear to regard Panotima eggs as food items. Small instar larvae of both species proved vulnerable, but the larger larvae appeared capable of escaping ant predation. Ant exclusion experiments in the field, using natural and artificially augmented ant densities, were carried out at two sites near Grahamstown. The dominant ant species was C. peringueyi. Neither the numbers of lepidopterans nor levels of herbivory were significantly reduced by the presence of ants . Despite the implications of the laboratory tests, the results of these field experiments did not support the hypothesis that ants which visit bracken extrafloral nectaries benefit the plant. Ant-bracken field studies on other continents also reported no significant ant-related effects, though marginal reductions in the abundance of certain herbivores have been noted at one site in the U.K. Since ant protection does not appear to be an inevitable consequence of having extrafloral nectaries, their value to bracken is in some doubt. The most likely situation where effective protection will occur is when high densities of vulnerable herbivores are preyed upon by large numbers of aggressive ants. However, even under these conditions, enhancement of plant fitness is not inevitable. This raises the question of why extrafloral nectaries have been retained in a plant that is as successful and widespread as bracken.
  • Full Text:
  • Date Issued: 1989

Investigation of the causative agents of the 1982 Gazankulu poliomyelitis outbreak, using four biochemical techniques

  • Authors: Gibson, Katherine Margaret
  • Date: 1989
  • Subjects: Poliomyelitis -- Analysis , Poliomyelitis -- History -- South Africa , Poliomyelitis vaccine -- Analysis
  • Language: English
  • Type: Thesis , Masters , MSc
  • Identifier: vital:3878 , http://hdl.handle.net/10962/d1001612
  • Description: Comparison of poliovirus strains was carried out to determine the origin of the virus in two isolates obtained during the 1982 outbreak of poliomyelitis in Gazankulu. Comparisons of the outbreak isolates with vaccine and wild-type strains of the same poliovirus type were carried out using four biochemical techniques. SDS-polyacrylamide gel electrophoresis (SDS-PAGE), two-dimensional thin-layer chromatography (TLC) and reversed-phase high-performance liquid-chromatography (RP-HPLC) were used for comparing viral capsid proteins. Comparison of poliovirus strains at a genetic level was carried out using two-dimensional oligonucleotide mapping of viral RNA. Results showed the type 1 poliovirus isolate, 5061, to be a novel wild-type poliovirus. The type 2 isolate, 5068, was closely related to the poliovirus type 2 Sabin vaccine strain, P712. It was concluded that the intrinsic variability of poliovirus strains was responsible for the appearance of isolate 5068
  • Full Text:
  • Date Issued: 1989
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