Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors

Faridoon, H; Edkins, Adrienne L; Isaacs, Michelle; Mnkandhla, Dumisani; Hoppe, Heinrich C; Kaye, Perry T

Title: Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors
Creator: Faridoon, H
Creator: Edkins, Adrienne L
Creator: Isaacs, Michelle
Creator: Mnkandhla, Dumisani
Creator: Hoppe, Heinrich C
Creator: Kaye, Perry T
Date Issued: 2016
Date: 2016
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/66289
Identifier: vital:28929
Identifier: https://doi.org/10.1016/j.bmcl.2016.05.023
Description: publisher version
Description: Encouraging selectivity and low micromolar activity against HeLa cervical carcinoma (IC50 ⩾ 3.0 μM) and the aggressive MDA-MB-231 triple negative breast carcinoma (IC50 ⩾ 9.6 μM) cell lines has been exhibited by a number of readily accessible 4-(N-benzylamino)cinnamate esters. The potential of the ligands as HIV-1 integrase inhibitors has also been examined.
Format: 3 pages
Format: pdf
Language: English
Relation: Bioorganic and Medicinal Chemistry Letters
Relation: Faridoon, H., Edkins, Adrienne L., Isaacs, Michelle, Hoppe, Heinrich C., Kaye, Perry T.(2016) Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors. Bioorganic and Medicinal Chemistry Letters, 26 (15), p. 3810-3812. ISSN: 0960-894X. https://doi.org/10.1016/j.bmcl.2016.05.023
Relation: Bioorganic and Medicinal Chemistry Letters volume 26 number 15 3810 3812 August 2016 0960-894X
Rights: Elsevier B.V.
Rights: Use of this resource is governed by the terms and conditions of the BioOrganic and Chemistry Letters Open Access Statement (https://www.elsevier.com/journals/bioorganic-and-medicinal-chemistry-letters/0960-894x/guide-for-authors)

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RU Department of Biochemistry, Microbiology and Biotechnology

Isaacs, Michelle (Mrs)

Hoppe, Heinrich C (Prof)

Kaye, Perry (Distinguished Fellow Emeritus Professor)

Edkins, Adrienne Lesley (Associate Prof)

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