- Title
- Extracellular Hsp90 and TGFP regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model
- Creator
- de la Mare, Jo-Anne
- Creator
- Jurgens, Tamarin
- Creator
- Edkins, Adrienne L
- Date Issued
- 2017
- Date
- 2017
- Type
- article
- Type
- text
- Identifier
- http://hdl.handle.net/10962/59920
- Identifier
- vital:27710
- Identifier
- https://doi.org/10.1186/s12885-017-3190-z
- Description
- Tumour metastasis remains the major cause of death in cancer patients and, to date, the mechanism and signalling pathways governing this process are not completely understood. The TGF-ß pathway is the most commonly mutated pathway in cancer, however its role in cancer progression is controversial as it can function as both a promoter and a suppressor of metastasis. Although previous studies have suggested a role for the molecular chaperone Hsp90 in regulating the TGF-ß pathway, the level at which this occurs as well as the consequences in terms of colon cancer metastasis are unknown.
- Format
- 16 pages
- Format
- Language
- English
- Relation
- BMC Cancer
- Relation
- de la Mare, J.A., Jurgens, T. and Edkins, A.L., 2017. Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. BMC cancer, 17(1), p.202
- Relation
- BMC Cancer 17 vol. 1 no. 1 16 2017 1471-2407
- Rights
- BMC Cancer
- Rights
- Use of this resource is governed by the terms and conditions of the bethesda Statement on Open Access Publishing
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Collections
RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
RU Department of Biochemistry, Microbiology and Biotechnology
De la Mare, Jo-Anne (Dr)
Edkins, Adrienne Lesley (Associate Prof)
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