- Title
- The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype:
- Creator
- Cornick, Jennifer E
- Creator
- Tastan Bishop, Özlem
- Creator
- Yalcin, Feyruz
- Creator
- Kiran, Anmol M
- Creator
- Kumwenda, Benjamin
- Creator
- Chaguza, Chrispin
- Creator
- Govindpershad, Shanil
- Creator
- Ousmane, Sani
- Creator
- Senghore, Madikay
- Creator
- du Plessis, Mignon
- Creator
- Pluschke, Gerd, 1952-
- Creator
- Ebruke, Chinelo
- Creator
- McGee, Lesley
- Creator
- Sigaùque , Beutel
- Creator
- Collard, Jean-Marc
- Creator
- Bentley, Stephen D
- Creator
- Kadioglu , Aras
- Creator
- Antonio, Martin
- Creator
- von Gottberg, Anne
- Creator
- French, Neil
- Creator
- Klugman, Keith P
- Creator
- Heyderman, Robert S
- Creator
- Alderson, Mark
- Creator
- Everett, Dean B
- Date Issued
- 2017
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/148318
- Identifier
- vital:38729
- Identifier
- DOI: 10.1016/j.vaccine.2016.12.037
- Description
- Serotype 1 is one of the most common causes of pneumococcal disease worldwide. Pneumococcal protein vaccines are currently being developed as an alternate intervention strategy to pneumococcal conjugate vaccines. Pre-requisites for an efficacious pneumococcal protein vaccine are universal presence and minimal variation of the target antigen in the pneumococcal population, and the capability to induce a robust human immune response. We used in silico analysis to assess the prevalence of seven protein vaccine candidates (CbpA, PcpA, PhtD, PspA, SP0148, SP1912, SP2108) among 445 serotype 1 pneumococci from 26 different countries, across four continents. CbpA (76%), PspA (68%), PhtD (28%), PcpA (11%) were not universally encoded in the study population, and would not provide full coverage against serotype 1.
- Format
- 9 pages
- Format
- Language
- English
- Relation
- Vaccine
- Relation
- Cornick, J.E., Bishop, Ö.T., Yalcin, F., Kiran, A.M., Kumwenda, B., Chaguza, C., Govindpershad, S., Ousmane, S., Senghore, M., du Plessis, M. and Pluschke, G., 2017. The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1. Vaccine, 35(6), pp.972-980.
- Relation
- Vaccine volume 35 number 6 972 980 2017 1873-2518
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Tastan Bishop, Ozlem (Prof)
RU Research Unit in Bioinformatics (RUBi)
RU Department of Biochemistry, Microbiology and Biotechnology
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