- Title
- Three new pentacyclic triterpenoids from twigs of Manniophyton fulvum (Euphorbiaceae)
- Creator
- Mbeunkeu, Ahri B D
- Creator
- Noundou, Xavier S
- Creator
- Krause, Rui W M
- Creator
- Teinkela, Jean E M
- Creator
- Laatsch, Hartmut
- Creator
- Azebaze, Anatole G B
- Creator
- Vardamides, Juliette C
- Creator
- Tala, Michel F
- Date Issued
- 2018
- Date
- 2018
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/126782
- Identifier
- vital:35922
- Identifier
- https://doi.org/10.1016/j.phytol.2018.06.019
- Description
- Phytochemical investigation of the methanol extracts of the twigs of Manniophyton fulvum has led to the isolation and characterization of three new pentacyclic triterpenoids, designated as 3α,28-dihydroxyfriedelan-1-one (1), manniotaraxerol A (3) and manniotaraxerol B (4), along with fourteen known compounds, 3α-hydroxy-1-oxofriedelane (2), betulinic acid (5), friedelin (S1), taraxerol (S2), a mixture of stigmasterol (S3) and β-sitosterol (S4), herranone (S5), docosanoic acid (S6), ursolic acid (S7), nasutin B (S8), bergenin (S9), stigmasterol-3-O-β-Dglucopyranoside (S10), 1,2-di-O-palmitoyl-3-O-(6-sulfo-α-D-quinovopyranosyl)glycerol (S11), and aridanin (S12). The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI and ESI-MS). 3α,28-Dihydroxyfriedelan-1-one (1), 3α-hydroxy-1-oxofriedelane (2), manniotaraxerol A (3), manniotaraxerol B (4), and betulinic acid (5) were evaluated against HeLa (human cervix adenocarcinoma) cancer cells. Manniotaraxerol A (3) showed weak in vitro cytotoxicity with a cell viability value of 49.3%. Betulinic acid (5) also showed significant cytotoxicity against HeLa cell with a cell viability value of 4.0%; the other compounds were inactive in this test.
- Format
- 8 pages
- Format
- Language
- English
- Relation
- Phytochemistry letters
- Relation
- Mbeunkeu, A.B.D., Azebaze, A.G.B., Tala, M.F., Teinkela, J.E.M., Noundou, X.S., Krause, R.W.M., Vardamides, J.C. and Laatsch, H., 2018. Three new pentacyclic triterpenoids from twigs of Manniophyton fulvum (Euphorbiaceae). Phytochemistry letters, 27, pp.1-8.
- Relation
- Phytochemistry letters number 27 2018 1876-7486
- Rights
- Phytochemistry letters
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Krause, Rui Werner Maçedo (Prof)
RU Department of Chemistry
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