Ferrocenyl and organic novobiocin derivatives: synthesis and their in vitro biological activity

Mbaba, Mziyanda; Mabhula, Amanda N; Boel, Natasha; Edkins, Adrienne L; Isaacs, Michelle; Hoppe, Heinrich C; Khanye, Setshaba D

Title: Ferrocenyl and organic novobiocin derivatives: synthesis and their in vitro biological activity
Creator: Mbaba, Mziyanda
Creator: Mabhula, Amanda N
Creator: Boel, Natasha
Creator: Edkins, Adrienne L
Creator: Isaacs, Michelle
Creator: Hoppe, Heinrich C
Creator: Khanye, Setshaba D
Date Issued: 2017
Date: 2017
Type: text
Type: article
Identifier: http://hdl.handle.net/10962/66189
Identifier: vital:28914
Identifier: https://doi.org/10.1016/j.jinorgbio.2017.04.014
Description: publisher version
Description: A focused series of novobiocin derivatives containing a ferrocene unit together with their corresponding organic novobiocin analogues have been synthesized in modest to good yields. These compounds were screened for biological activity against a chloroquine-sensitive strain of Plasmodium falciparum (3D7) and human breast cancer cell line (HCC38). With the exception of compounds 5c and 5d, the general trend observed is that incorporation of the ferrocene moiety into novobiocin scaffold resulted in compounds 6a–d/6f showing enhanced activity compared to organic analogues 5a–b and 5e–f.
Format: 6 pages
Format: pdf
Language: English
Relation: Journal of Inorganic Biochemistry
Relation: Mbaba, Mziyanda, Mabhula, Amanda N., Boel, Natasha, Edkins, Adrienne L., Isaacs, Michelle, Hoppe, Heinrich C., Khanye, Setshaba D. (2017) Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity. Journal of Inorganic Biochemistry, 172, p. 88 – 93. SN - 0162-0134. https://doi.org/10.1016/j.jinorgbio.2017.04.014
Relation: Journal of Inorganic Biochemistry volume 172 number 88 93 July 2017 0162-0134
Rights: Elsevier B.V.
Rights: Use of this resource is governed by the terms and conditions of the Journal of Inorganic Biochemistry Guide for Authors Open Access Statement (https://www.elsevier.com/journals/journal-of-inorganic-biochemistry/0162-0134/guide-for-authors)

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RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response

RU Department of Biochemistry, Microbiology and Biotechnology

Isaacs, Michelle (Mrs)

RU Centre for Chemico- and Biomedicinal Research (CCBR)

Hoppe, Heinrich C (Prof)

Edkins, Adrienne Lesley (Associate Prof)

Khanye, David Setshaba (Associate Prof)

RU Department of Chemistry

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