The human skin-blanching assay for comparing topical corticosteroid availability

Title: The human skin-blanching assay for comparing topical corticosteroid availability
Creator: Smith, Eric W
Creator: Meyer, Eric
Creator: Haigh, John M
Creator: Maibach, Harold I
Date Issued: 1991
Date: 1991
Type: Article
Identifier: vital:6433
Identifier: http://hdl.handle.net/10962/d1006604
Description: The human skin blanching assay remains in widespread use as a reliable, qualitative, comparative indicator of topical corticosteroid availability and potency. The experimental refinements promulgated by certain researchers in this field have yielded a versatile bioassay for the accurate assessment of new drugs or delivery vehicles. With the increasing appearance of generic topical corticosteroid formulations which compete with trade-name equivalents, the vital importance of this assay in regulatory affairs and assessing bioequivalence has been re-emphasized. It is stressed that if the blanching assay is to be used in this sphere, then multiple-reading trials must be conducted; important registration or clinical decisions cannot be made with any validity from short-term assessments.
Format: 4 pages
Format: pdf
Language: English
Relation: Smith, E.W. and Meyer, E. and Haigh, J.M. and Maibach, H.I. (1991) The human skin-blanching assay for comparing topical corticosteroid availability. Journal of Dermatological Treatment, 2 . pp. 69-72.

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RU Department of Pharmacy

Haigh, JM (Prof)

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