- Title
- Cytotoxicity of triterpenoids from Clerodendrum glabrum against triple negative breast cancer cells in vitro:
- Creator
- Teclegeorgish, Zecarias W
- Creator
- Mokgalaka, Ntebogeng S
- Creator
- Vukea, Nyeleti
- Creator
- de la Mare, Jo-Anne
- Creator
- Tembu, Vuyelwa J
- Date Issued
- 2020
- Date
- 2020
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/161511
- Identifier
- vital:40634
- Identifier
- https://doi.org/10.1016/j.sajb.2020.07.009
- Description
- Clerodendrum glabrum is an indigenous medicinal plant that is used to treat cough, cold, sore throat and chest complaints. The stem bark of Clerodendrum glabrum afforded four tritepenoids namely, 3β-olean-12-en-3-yl palmitate (β-amyrin palmitate), (1), 3β hydroxy 5-glutinene (glutinol), (2), 3β-lup-20(29)-en-3-palmitate (Lupeol-3-palmitate), (3), 3β-lup-20(29)-en-3-ol (lupeol) (4) and one common phytosterol (stigmasterol) (5). The structures were established on the basis of their spectroscopic analysis. The compounds were screened for cytotoxicity against the HCC70 triple negative breast cancer (TNBC), MCF-7 hormone receptor positive breast cancer and MCF-12A non-cancerous mammary epithelial cell lines.
- Format
- 7 pages
- Format
- Language
- English
- Relation
- South African Journal of Botany
- Relation
- Teclegeorgish, Z.W., Mokgalaka, N.S., Vukea, N., de la Mare, J.A. and Tembu, V.J., 2020. Cytotoxicity of triterpenoids from Clerodendrum glabrum against triple negative breast cancer cells in vitro. South African Journal of Botany, 133, pp.144-150
- Relation
- South African Journal of Botany volume 133 number 144 150 September 2020 0254-6299
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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RU Department of Biochemistry, Microbiology and Biotechnology
De la Mare, Jo-Anne (Dr)
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