- Title
- Semi-synthesis and evaluation of sargahydroquinoic acid derivatives as potential antimalarial agents:
- Creator
- Munedzimwe, Tatenda C
- Creator
- van Zyl, Rovyn L
- Creator
- Heslop, Donovan C
- Creator
- Edkins, Adrienne L
- Creator
- Beukes, Denzil R
- Date Issued
- 2019
- Date
- 2019
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/163456
- Identifier
- vital:41040
- Identifier
- DOI: 10.3390/medicines6020047
- Description
- Malaria continues to present a major health problem, especially in developing countries. The development of new antimalarial drugs to counter drug resistance and ensure a steady supply of new treatment options is therefore an important area of research. Meroditerpenes have previously been shown to exhibit antiplasmodial activity against a chloroquinone sensitive strain of Plasmodium falciparum (D10). In this study we explored the antiplasmodial activity of several semi-synthetic analogs of sargahydroquinoic acid.
- Format
- Language
- English
- Relation
- Medicines
- Relation
- Munedzimwe, T.C., Van Zyl, R.L., Heslop, D.C., Edkins, A.L. and Beukes, D.R., 2019. Semi-synthesis and evaluation of sargahydroquinoic acid derivatives as potential antimalarial agents. Medicines, 6(2), p.47
- Relation
- Medicines volume 6 number 2 1 9 February 2019 2305-6320
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the MDPI Open Access Statement (https://www.int-res.com/journals/terms-of-use/)
- Hits: 1496
- Visitors: 1614
- Downloads: 140
Collections
RU DST/NRF SARChI for Molecular and Cellular Biology of the Eukaryotic Stress Response
RU Department of Biochemistry, Microbiology and Biotechnology
Edkins, Adrienne Lesley (Associate Prof)
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Semi-synthesis and evaluation of sargahydroquinoic acid derivatives as potential antimalarial agents.pdf | 1 MB | Adobe Acrobat PDF | View Details Download |