- Title
- In vitro antimicrobial activity of the methanol extract and compounds from the wood of Ficus elastica Roxb. ex Hornem. aerial roots
- Creator
- Meyer, Franck
- Creator
- Fannang, Simone Véronique
- Creator
- Noundou, Xavier Siwe
- Creator
- Krause, Rui W M
- Creator
- Teinkela, Jean Emmanuel Mbosso
- Creator
- Vardamides, Juliette Cathérine
- Creator
- Mpondo, Albert Emmanuel Mpondo
- Creator
- Azebaze, Anatole Guy Blaise
- Creator
- Nguedia, Jules Clément Assob
- Date Issued
- 2017
- Date
- 2017
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/126154
- Identifier
- vital:35854
- Identifier
- https://doi.org/10.1016/j.sajb.2017.03.026
- Description
- Ficus elastica Roxb. ex Hornem., an edible plant belonging to the family of Moraceae, is traditionally used against skin infections and allergies besides having diuretic properties. This study aimed at investigating the antimicrobial activity of the wood of F. elastica aerial roots against a set of bacteria (Staphylococcus aureus; Escherichia coli, Proteus vulgaris, Providencia stuartii and Pseudomonas aeruginosa) and a yeast (Candida albicans). A mixture of linear aliphatic alkanes with n-hexacosane as major compound, β-sitosterol, biochanin A, sitosteryl 3-O-β-D-glucopyranoside (1), elasticamide (2), elastiquinone (3) and ficusoside B (4) were purified and characterized. Antimicrobial activities, expressed as minimum inhibitory concentration (MIC), indicated that the methanol extract showed MIC of 39.1 μg/mL; the lowest values were obtained for 3 and 4, with MIC as low as 4.9 μg/mL, smaller than the values of reference antibiotics (25 μg/mL). Furthermore, as most of the studied samples exhibited Minimum Microbicidal Concentration/Minimum Inhibitory Concentration (MMC/MIC) ratios lower than 4, a microbicidal effect was clearly exhibited. The overall results provided evidence that the wood of F. elastica aerial roots, as well as some of its isolated components might be potential sources of new antimicrobial drugs.
- Format
- 5pages
- Format
- Language
- English
- Relation
- South African journal of botany
- Relation
- Teinkela, J.M., Noundou, X.S., Fannang, S., Meyer, F., Vardamides, J.C., Mpondo, E.M., Krause, R.W.M., Azebaze, A.G.B. and Nguedia, J.C.A., 2017. In vitro antimicrobial activity of the methanol extract and compounds from the wood of Ficus elastica Roxb. ex Hornem. aerial roots. South African journal of botany, 111, pp.302-306.
- Relation
- South African journal of botany number 111 302 306 2017 0254-6299
- Rights
- South African journal of botany
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
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Krause, Rui Werner Maçedo (Prof)
RU Department of Chemistry
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