- Title
- Cyclodextrin grafted calcium carbonate vaterite particles: efficient system for tailored release of hydrophobic anticancer or hormone drugs
- Creator
- Lakkakula, Jaya R
- Creator
- Kurapati, Rajendra
- Creator
- Tynga, Ivan
- Creator
- Krause, Rui W M
- Creator
- Abrahamse, Heidi
- Creator
- Raichur, Ashok M
- Date Issued
- 2016
- Date
- 2016
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/125435
- Identifier
- vital:35783
- Identifier
- https://doi.org/10.1039/C6RA12951J
- Description
- Porous CaCO3 microparticles have been used earlier for sustained drug release of hydrophilic drugs but have certain drawbacks for use with hydrophobic drugs. Hence, to overcome these drawbacks, a novel composite of CaCO3 along with cyclodextrin (CD–CaCO3) for the delivery of hydrophobic drugs was developed. Cyclodextrins (CDs), when incorporated within CaCO3, increased the porosity and surface area of microparticles thereby enhancing the encapsulation efficiency of hydrophobic drugs (5-Fluorouracil or Na-L-thyroxine) by forming inclusion complexes with cyclodextrin. Thermogravimetric and FTIR studies confirmed the interaction between the cyclodextrin and CaCO3 microparticles. Raman spectra confirmed the peak of vaterite crystals before and after loading of hydrophobic drugs within the composite. In vitro release studies when performed at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) showed release at low pH as CaCO3 is soluble at acidic pH unlike slower release at basic pH. Release kinetics followed a Higuchi kinetic model at pH 4.8 (5-Fu) and pH 1.2 (Na-L-thy) respectively.
- Format
- 12 pages
- Format
- Language
- English
- Relation
- RSC Advances
- Relation
- Lakkakula, J.R., Kurapati, R., Tynga, I., Abrahamse, H., Raichur, A.M. and Krause, R.W.M., 2016. Cyclodextrin grafted calcium carbonate vaterite particles: efficient system for tailored release of hydrophobic anticancer or hormone drugs. RSC Advances, 6(106), pp.104537-104548.
- Relation
- RSC Advances number 6 number 106 104537 104548 2016 2046-2069
- Rights
- RSC Advances
- Rights
- Use of this resource is governed by the terms and conditions of the Royal Society of Chemistry Terms & Conditions Statement (http://www.rsc.org/help-legal/)
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Krause, Rui Werner Maçedo (Prof)
RU Department of Chemistry
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Cyclodextrin.xml | 5 KB | XML Document | View Details Download | ||
| View Details Download | SOURCE2 | Cyclodextrin grafted calcium carbonate vaterite particles: efficient system for tailored release of hydrophobic anticancer or hormone drugs | 2 MB | Adobe Acrobat PDF | View Details Download |