The origins and subsequent development of Administration Boards
- Authors: Humphries, Richard
- Date: 1983
- Subjects: South Africa -- Politics and government -- 20th century , Influx control -- South Africa , Public administration -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2854 , http://hdl.handle.net/10962/d1006873 , South Africa -- Politics and government -- 20th century , Influx control -- South Africa , Public administration -- South Africa
- Description: Until the introduction of administration boards in 1972-1973, the responsibility for administering the urban black townships in "white" South Africa was vested with the municipalities as agents of the Department of Bantu Administration and Development. The establishment of administration boards to replace the municipalities' Non-European Affairs Departments reflected the determination of the Department of Bantu Administration and Development to secure tighter direct control over the implementation of policy, particularly that affecting influx control and labour regulation. The decision to end municipal control was made after the report of the Van Rensburg Inter-Departmental Committee of Inquiry into Control Measures, which reported in 1967. The report's concern that influx control was not working as intended, coupled with doubts about the political autonomy of Opposition controlled municipalities, which dated back to the 1950s, were the major reasons for the introduction of administration boards.
- Full Text:
- Date Issued: 1983
- Authors: Humphries, Richard
- Date: 1983
- Subjects: South Africa -- Politics and government -- 20th century , Influx control -- South Africa , Public administration -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2854 , http://hdl.handle.net/10962/d1006873 , South Africa -- Politics and government -- 20th century , Influx control -- South Africa , Public administration -- South Africa
- Description: Until the introduction of administration boards in 1972-1973, the responsibility for administering the urban black townships in "white" South Africa was vested with the municipalities as agents of the Department of Bantu Administration and Development. The establishment of administration boards to replace the municipalities' Non-European Affairs Departments reflected the determination of the Department of Bantu Administration and Development to secure tighter direct control over the implementation of policy, particularly that affecting influx control and labour regulation. The decision to end municipal control was made after the report of the Van Rensburg Inter-Departmental Committee of Inquiry into Control Measures, which reported in 1967. The report's concern that influx control was not working as intended, coupled with doubts about the political autonomy of Opposition controlled municipalities, which dated back to the 1950s, were the major reasons for the introduction of administration boards.
- Full Text:
- Date Issued: 1983
Aspects of prostacyclin in experimental hypertension
- Authors: Botha, Julia Hilary
- Date: 1983
- Subjects: Prostacyclin Prostaglandins Prostaglandin endoperoxides Thromboxanes Hypertension
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3825 , http://hdl.handle.net/10962/d1006109
- Description: A new prostaglandin - prostaglandin X (later renamed prostacyclin or prostaglandin I₂ (PGI₂)), was discovered by Moncada, Gryglewski, Bunting and Vane in 1976. This unstable substance was shown to be produced by vascular tissue and to be a vasodilator and the most potent endogenous inhibitor of platelet aggregation known. Because of its properties, it appeared that a lack of it may be related to the development and or maintenance of hypertension, a disorder featuring vasoconstriction and an increased tendency to arterial thrombosis. The present studies aimed to investigate this possibility using a rat model. A bioassay for prostacyclin was first perfected. This consisted of a modification of the method used by Moncada, Higgs and Vane (1977): PGI₂ released by rat aortic strips, during incubation in tris buffer, was measured by assessing the ability of the incubate to inhibit adenosine diphosphate induced aggregation of human platelets, as compared to the inhibitory effect of standard prostacyclin sodium salt. The specificity of the assay for the detection of PGI₂ was tested. The abil ity of hypertensive rat aorta to release prostacycl in was investigated in two studies. The first compared aortas of Wistar rats of the New Zealand genetically hypertensive strain (GH) with those of matched normotensive Wistar controls. In the second study, hypertension was induced by wrappi ng the ri ght kidney with surgical silk and removing the contralateral kidney. Ten weeks later, aortic generation of prostacyclin by these animals was compared with that of matched sham controls which had received identical surgical manipulation but for the application of silk to the right kidney. Contrary to expectation, in both forms of hypertension, aortas of the rats with elevated pressure produced consistently more prostacyclin than those of matched controls. In order to discover more about the relationship between elevated pressure and elevated PGI₂ production, the effect of pressure reduction with hypotensive agents on the ability of GH rat aortas to produce prostacyclin, was investigated. After pressure had been controlled within normal range for one week (achieved by oral administration of furosemide, dihydralazine and reserpine for one month), aortic PGI₂ was reduced in comparison with matched GH controls. However, the reduction was not consistent and statistical significance was not reached. Because it was subsequently reported by other workers, that some of the hypotensive agents which had been employed may effect prostaglandin levels per se, no conclusions could be drawn from this study as to any possible direct relationships between pressure and aortic prostacyclin generating capacity. A further means of reducing elevated pressure (which had no inherent effect on prostaglandin levels) was thus sought. A mechanical method was eventually selected, application of a silver clip to the aortas of GH rats, just below the diaphragm, producing an immediate reduction in pressure distal to the constriction. Eighteen hours with later, PGI₂ production by these distal aortas those of matched sham GH controls and was was compared found to be consistently reduced. These results indicate that the ability to produce PGI₂ may be influenced by prior local pressure changes and that the increased capacity of hypertensive rat aortas to generate prostacyclin may be related to the increased mechanical transmural stress consequent on elevated pressure. Since haemostatic balance must be influenced not only by vascular PGI₂ generation but also by platelet sensitivity to PGI₂, the response of GH platelets to the anti-aggregatory effect of prostacyc1in was also investigated. As it had been shown by Sinzinger, Si1berbauer, Horsch and Gall (1981) that intra-arterial infusion of PGI₂ in humans decreased platelet sensitivity to the substance, the possibility existed that platelet sensitivity in hypertension might be reduced. This hypothesis was, however, invalidated as the sensitivity of GH platelets to the anti-aggregatory effect of PGI₂ was almost identical to that of normotensive controls. The shortcomings of the methodology and the possible importance of these findings in the hypertensive animal are discussed. The idea that elevated PGI₂ in hypertension may play a protective role both with respect to platelet aggregation and in attenuating further pressure rises is considered. It is finally suggested that it will be possible to draw more accurate conclusions as to the meaning of the increased PGI₂ generation in hypertension (both in relation to vascular tone and platelet function) only when details of production of, and sensitivity to, thromboxane A₂ are known. Thromboxane A₂ (TXA₂) is a vasoconstrictor and promotor of aggregation (Hamberg, Svensson and Samuelson, 1975) and it may be that, despite elevated vascular PGI₂ generation, the TXA₂/PGI₂ balance is still tipped in favour of vasoconstriction and platelet aggregation in hypertension.
- Full Text:
- Date Issued: 1983
- Authors: Botha, Julia Hilary
- Date: 1983
- Subjects: Prostacyclin Prostaglandins Prostaglandin endoperoxides Thromboxanes Hypertension
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3825 , http://hdl.handle.net/10962/d1006109
- Description: A new prostaglandin - prostaglandin X (later renamed prostacyclin or prostaglandin I₂ (PGI₂)), was discovered by Moncada, Gryglewski, Bunting and Vane in 1976. This unstable substance was shown to be produced by vascular tissue and to be a vasodilator and the most potent endogenous inhibitor of platelet aggregation known. Because of its properties, it appeared that a lack of it may be related to the development and or maintenance of hypertension, a disorder featuring vasoconstriction and an increased tendency to arterial thrombosis. The present studies aimed to investigate this possibility using a rat model. A bioassay for prostacyclin was first perfected. This consisted of a modification of the method used by Moncada, Higgs and Vane (1977): PGI₂ released by rat aortic strips, during incubation in tris buffer, was measured by assessing the ability of the incubate to inhibit adenosine diphosphate induced aggregation of human platelets, as compared to the inhibitory effect of standard prostacyclin sodium salt. The specificity of the assay for the detection of PGI₂ was tested. The abil ity of hypertensive rat aorta to release prostacycl in was investigated in two studies. The first compared aortas of Wistar rats of the New Zealand genetically hypertensive strain (GH) with those of matched normotensive Wistar controls. In the second study, hypertension was induced by wrappi ng the ri ght kidney with surgical silk and removing the contralateral kidney. Ten weeks later, aortic generation of prostacyclin by these animals was compared with that of matched sham controls which had received identical surgical manipulation but for the application of silk to the right kidney. Contrary to expectation, in both forms of hypertension, aortas of the rats with elevated pressure produced consistently more prostacyclin than those of matched controls. In order to discover more about the relationship between elevated pressure and elevated PGI₂ production, the effect of pressure reduction with hypotensive agents on the ability of GH rat aortas to produce prostacyclin, was investigated. After pressure had been controlled within normal range for one week (achieved by oral administration of furosemide, dihydralazine and reserpine for one month), aortic PGI₂ was reduced in comparison with matched GH controls. However, the reduction was not consistent and statistical significance was not reached. Because it was subsequently reported by other workers, that some of the hypotensive agents which had been employed may effect prostaglandin levels per se, no conclusions could be drawn from this study as to any possible direct relationships between pressure and aortic prostacyclin generating capacity. A further means of reducing elevated pressure (which had no inherent effect on prostaglandin levels) was thus sought. A mechanical method was eventually selected, application of a silver clip to the aortas of GH rats, just below the diaphragm, producing an immediate reduction in pressure distal to the constriction. Eighteen hours with later, PGI₂ production by these distal aortas those of matched sham GH controls and was was compared found to be consistently reduced. These results indicate that the ability to produce PGI₂ may be influenced by prior local pressure changes and that the increased capacity of hypertensive rat aortas to generate prostacyclin may be related to the increased mechanical transmural stress consequent on elevated pressure. Since haemostatic balance must be influenced not only by vascular PGI₂ generation but also by platelet sensitivity to PGI₂, the response of GH platelets to the anti-aggregatory effect of prostacyc1in was also investigated. As it had been shown by Sinzinger, Si1berbauer, Horsch and Gall (1981) that intra-arterial infusion of PGI₂ in humans decreased platelet sensitivity to the substance, the possibility existed that platelet sensitivity in hypertension might be reduced. This hypothesis was, however, invalidated as the sensitivity of GH platelets to the anti-aggregatory effect of PGI₂ was almost identical to that of normotensive controls. The shortcomings of the methodology and the possible importance of these findings in the hypertensive animal are discussed. The idea that elevated PGI₂ in hypertension may play a protective role both with respect to platelet aggregation and in attenuating further pressure rises is considered. It is finally suggested that it will be possible to draw more accurate conclusions as to the meaning of the increased PGI₂ generation in hypertension (both in relation to vascular tone and platelet function) only when details of production of, and sensitivity to, thromboxane A₂ are known. Thromboxane A₂ (TXA₂) is a vasoconstrictor and promotor of aggregation (Hamberg, Svensson and Samuelson, 1975) and it may be that, despite elevated vascular PGI₂ generation, the TXA₂/PGI₂ balance is still tipped in favour of vasoconstriction and platelet aggregation in hypertension.
- Full Text:
- Date Issued: 1983
Geology and mine planning
- Authors: Maturana-Bascope, M
- Date: 1983
- Subjects: Geology , Mining geology , Geology, Economics
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5027 , http://hdl.handle.net/10962/d1006896
- Description: From introduction: This dissertation aims to review the main aspects involved in mine planning, in order to provide the geologists with the main criteria to obtain a preliminary estimate of the minability of an in situ orebody, and to make the geologists aware of the information they can contribute to the planning engineers. Furthermore, an understanding of the basic principles behind mine planning may help the exploration geologist to select more realistic targets of exploration.
- Full Text:
- Date Issued: 1983
- Authors: Maturana-Bascope, M
- Date: 1983
- Subjects: Geology , Mining geology , Geology, Economics
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5027 , http://hdl.handle.net/10962/d1006896
- Description: From introduction: This dissertation aims to review the main aspects involved in mine planning, in order to provide the geologists with the main criteria to obtain a preliminary estimate of the minability of an in situ orebody, and to make the geologists aware of the information they can contribute to the planning engineers. Furthermore, an understanding of the basic principles behind mine planning may help the exploration geologist to select more realistic targets of exploration.
- Full Text:
- Date Issued: 1983
A taxonomic study of the fish genus Petrotilapia (Pisces: Cichlidae) from Lake Malawi
- Authors: Marsh, A C
- Date: 1983
- Subjects: Petrotilapia -- Nyasa, Lake -- Classification , Fishes -- Nyasa, Lake -- Classification
- Language: English
- Type: Text
- Identifier: vital:15012 , http://hdl.handle.net/10962/d1019745 , Ichthyological Bulletin of the J.L.B. Smith Institute of Ichthyology; No. 48
- Description: The type-species of the cichlid fish genus Petrotilapia Trewavas 1935, P. tridentiger, is redescribed and two new species, P. genalutea and P. nigra, are described. These three species occur sympatrically at Monkey Bay. Morphological differences between the three species are slight and of little diagnostic value. Live coloration is the most important taxonomic character and can be used reliably to identify adults of the three species. Field observations of live fishes are shown to be of paramount importance in taxonomic studies of the genus Petrotilapia. , Rhodes University Libraries (Digitisation)
- Full Text:
- Date Issued: 1983
- Authors: Marsh, A C
- Date: 1983
- Subjects: Petrotilapia -- Nyasa, Lake -- Classification , Fishes -- Nyasa, Lake -- Classification
- Language: English
- Type: Text
- Identifier: vital:15012 , http://hdl.handle.net/10962/d1019745 , Ichthyological Bulletin of the J.L.B. Smith Institute of Ichthyology; No. 48
- Description: The type-species of the cichlid fish genus Petrotilapia Trewavas 1935, P. tridentiger, is redescribed and two new species, P. genalutea and P. nigra, are described. These three species occur sympatrically at Monkey Bay. Morphological differences between the three species are slight and of little diagnostic value. Live coloration is the most important taxonomic character and can be used reliably to identify adults of the three species. Field observations of live fishes are shown to be of paramount importance in taxonomic studies of the genus Petrotilapia. , Rhodes University Libraries (Digitisation)
- Full Text:
- Date Issued: 1983
Statistical base for planning service centres in Transkei's north-west region
- Osmond, Lange, Vandeverre, Haarhoff, Goldswain and Burger
- Authors: Osmond, Lange, Vandeverre, Haarhoff, Goldswain and Burger
- Date: 1983
- Subjects: f-sa , 0-20 km 30.5595° S, 22.9375° E , Transkei (South Africa) Maps , Regional planning -- South Africa -- Transkei Maps , Regional development -- South Africa -- Transkei Maps , Population density -- South Africa -- Transkei Maps , South Africa History 1909-1961 Maps
- Language: English
- Type: maps , digital maps , cartographic
- Identifier: http://hdl.handle.net/10962/121750 , vital:35142 , Cory Library for Humanities Research, Rhodes University Library, Grahamstown, South Africa , MP1881
- Description: Maps to accompany "Statistical base for planning service centres in Transkei's north-west region" by Osmond Lange Vandeverre Haarhoff Goldswain and Burger, architects and regional planners. For the Department of Commerce, Industry and Tourism, Republic of Transkei. Map 1 north west region, Map 2 north east region.
- Full Text: false
- Date Issued: 1983
- Authors: Osmond, Lange, Vandeverre, Haarhoff, Goldswain and Burger
- Date: 1983
- Subjects: f-sa , 0-20 km 30.5595° S, 22.9375° E , Transkei (South Africa) Maps , Regional planning -- South Africa -- Transkei Maps , Regional development -- South Africa -- Transkei Maps , Population density -- South Africa -- Transkei Maps , South Africa History 1909-1961 Maps
- Language: English
- Type: maps , digital maps , cartographic
- Identifier: http://hdl.handle.net/10962/121750 , vital:35142 , Cory Library for Humanities Research, Rhodes University Library, Grahamstown, South Africa , MP1881
- Description: Maps to accompany "Statistical base for planning service centres in Transkei's north-west region" by Osmond Lange Vandeverre Haarhoff Goldswain and Burger, architects and regional planners. For the Department of Commerce, Industry and Tourism, Republic of Transkei. Map 1 north west region, Map 2 north east region.
- Full Text: false
- Date Issued: 1983
A study in local history: Grahamstown, 1883-1904
- Authors: Sellick, Rose-Mary
- Date: 1983
- Subjects: Grahamstown (South Africa) -- History
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2556 , http://hdl.handle.net/10962/d1002409 , Grahamstown (South Africa) -- History
- Description: [From the Preface]: A Study in Local History: Grahamstown 1883-1904 aims to draw into a coherent picture the threads of political attitudes, approaches to racial issues and changes confronting the late Victorians in Grahamstown, particularly in the areas of sanitation, public health and shifting commercial frontiers. The relation of local development to national affairs has been investigated, although attempts to define exactly how the former influenced the latter, and vice versa, would involve one in the proverbial chicken-and-egg syndrome. Let it suffice to say that an understanding of events in the microcosm, or locality, lends clarity to the cross-current of affairs at the national level. It begins at the point where Grahamstown's commercial importance in the Eastern Cape declines after a flourish of hopes in the prospects of the Port Alfred harbour as a means of bringing trade back to Grahamstown. The study concludes when the foundation of Rhodes University College in 1904, provides a new centre of development for the city.
- Full Text:
- Date Issued: 1983
- Authors: Sellick, Rose-Mary
- Date: 1983
- Subjects: Grahamstown (South Africa) -- History
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2556 , http://hdl.handle.net/10962/d1002409 , Grahamstown (South Africa) -- History
- Description: [From the Preface]: A Study in Local History: Grahamstown 1883-1904 aims to draw into a coherent picture the threads of political attitudes, approaches to racial issues and changes confronting the late Victorians in Grahamstown, particularly in the areas of sanitation, public health and shifting commercial frontiers. The relation of local development to national affairs has been investigated, although attempts to define exactly how the former influenced the latter, and vice versa, would involve one in the proverbial chicken-and-egg syndrome. Let it suffice to say that an understanding of events in the microcosm, or locality, lends clarity to the cross-current of affairs at the national level. It begins at the point where Grahamstown's commercial importance in the Eastern Cape declines after a flourish of hopes in the prospects of the Port Alfred harbour as a means of bringing trade back to Grahamstown. The study concludes when the foundation of Rhodes University College in 1904, provides a new centre of development for the city.
- Full Text:
- Date Issued: 1983
An investigation of the shared experience of children's literature, with particular reference to the teacher reading aloud, in senior primary classes
- Authors: McKellar, David William
- Date: 1983
- Subjects: Reading (Elementary) -- South Africa Teachers -- Training of -- South Africa Children's literature Children -- Books and reading
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1919 , http://hdl.handle.net/10962/d1007401
- Full Text:
- Date Issued: 1983
- Authors: McKellar, David William
- Date: 1983
- Subjects: Reading (Elementary) -- South Africa Teachers -- Training of -- South Africa Children's literature Children -- Books and reading
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: vital:1919 , http://hdl.handle.net/10962/d1007401
- Full Text:
- Date Issued: 1983
The parrotfishes of the subfamily Scarinae of the Western Indian Ocean with descriptions of three new species
- Randall, John E, 1924-, Bruce, Robin W
- Authors: Randall, John E, 1924- , Bruce, Robin W
- Date: 1983
- Language: English
- Type: Text
- Identifier: vital:15013 , http://hdl.handle.net/10962/d1019747 , ISSN 0073-4381 , Ichthyological Bulletin of the J.L.B. Smith Institute of Ichthyology; No. 47
- Description: The following 26 previously described species of Parrotfishes of the subfamily Scarinae are found in the Indian Ocean west of the southern tip of India (listed in the parentheses are the range, when restricted to some part of the western Indian Ocean, and junior synonyms not previously documented): Bolbometopon muricatum (Valenciennes) (Callyodon shimoniensis Smith is a synonym); Cetoscarus bicolor (Rüppell) (Scarus roseiceps Valenciennes is a synonym); Hipposcarus harid (Forsskal) [H. longiceps (Valenciennes) is a closely related allopatric species from the Pacific]; Scarus arabicus (Steindachner) (southern Arabian Peninsula and Gulf of Oman; only two specimens known); Scarus capistratoides Bleeker; Scarus caudofasciatus (Gunther) (Callyodon rubrofasciatus Smith is a synonym); Scarus collana Rüppell (a Red Sea endemic; Pseudoscarus ismailius Kossmann and Rauber and S. ghardaqensis Bebars are synonyms); Scarus cyanescens Valenciennes (Pseudoscarus chloromelas Playfair and Gunther is a synonym); Scarus enneacanthus Lacepede; Scarus falcipinnis (Playfair) (Callyodon pindae Smith and C. improvisus Smith are synonyms); Scarus ferrugineus Forsskal (Red Sea and Gulf of Aden; Pseudoscarus augustinus Kossmann and Rauber is a synonym); Scarus festivus Valenciennes (Callyodon lunula Snyder is a synonym); Scarus frenatus Lacepede; Scarus fuscopurpureus (Klunzinger) (Red Sea to Gulf of Oman; Pseudoscarus collana var. eques an Steindachner is a synonym); Scarus ghobban Forsskal (5. lacerta Valenciennes, Callyodon speigleri Smith, and S. fehlmanni Schultz are synonyms), Scarus gibbus Rüppell (Pseudoscarus frontalis Macleay is a synonym and a homonym); Scarus globiceps Valenciennes (S. lepidus Jenyns is a synonym); Scarus niger Forsskal (Pseudoscarus madagascariensis Steindachner is a synonym); Scarus prasiognathos Valenciennes (Maldive Islands appear to the westernmost record; S. chlorodon Jenyns, 5. Singaporensis Bleeker and S. janthochir Bleeker are synonyms); Scarus psittacus Forsskal (5. hertit [Ehrenberg] Valenciennes in C. & V., S. venosus Valenciennes, and S. taeniurus Valenciennes are synonyms); Scarus rubroviolaceus Bleeker (.Pseudoscarus rostratus Gunther is a synonym and a homonym); Scarus russelii Valenciennes (Xanothon fowled Smith is a synonym; initial phase often misidentified as S. venosus)’, Scarus scaber Valenciennes; Scarus sordidus Forsskal (S. spilurus Valenciennes is a synonym, and S. purpureus Valenciennes a synonym and homonym); Scarus tricolor Bleeker (Callyodon mus Smith and C. urbanus Smith are synonyms; initial phase often misidentified as S. Lepidus and the terminal phase as S. pectoralis or S. cyanognathos)’, Scarus viridifucatus (Smith) (Callyodon malindiensis Smith is a synonym), a close relative of S. spinus of the Pacific. Three new species of Scarus are described: S. atrilunula, from Kenya, is in the sordidus complex (initial phase was misidentified as rhoduropterus and the terminal male as capistratoides by Smith, 1956, 1959; S. genazonatus from the Red Sea and Gulf of Aden, also related to S. sordidus, differing chiefly in colour (the most distinctive colour marking of the terminal male is a broad stripe on lower cheek); and S. persicus from the Persian Gulf appears to be related to S. ferrugineus (initial phase light brownish-grey with two rows of small whitish spots on side, and median fin and pelvic fins edged in blue; terminal male similar to that of ferrugineus but with a blackish bar in middle of body). Colour photographs of fresh specimens of all 29 species are presented. Initial and terminal-phase adults are illustrated for most species, and juveniles for some. , Rhodes University Libraries (Digitisation)
- Full Text:
- Date Issued: 1983
- Authors: Randall, John E, 1924- , Bruce, Robin W
- Date: 1983
- Language: English
- Type: Text
- Identifier: vital:15013 , http://hdl.handle.net/10962/d1019747 , ISSN 0073-4381 , Ichthyological Bulletin of the J.L.B. Smith Institute of Ichthyology; No. 47
- Description: The following 26 previously described species of Parrotfishes of the subfamily Scarinae are found in the Indian Ocean west of the southern tip of India (listed in the parentheses are the range, when restricted to some part of the western Indian Ocean, and junior synonyms not previously documented): Bolbometopon muricatum (Valenciennes) (Callyodon shimoniensis Smith is a synonym); Cetoscarus bicolor (Rüppell) (Scarus roseiceps Valenciennes is a synonym); Hipposcarus harid (Forsskal) [H. longiceps (Valenciennes) is a closely related allopatric species from the Pacific]; Scarus arabicus (Steindachner) (southern Arabian Peninsula and Gulf of Oman; only two specimens known); Scarus capistratoides Bleeker; Scarus caudofasciatus (Gunther) (Callyodon rubrofasciatus Smith is a synonym); Scarus collana Rüppell (a Red Sea endemic; Pseudoscarus ismailius Kossmann and Rauber and S. ghardaqensis Bebars are synonyms); Scarus cyanescens Valenciennes (Pseudoscarus chloromelas Playfair and Gunther is a synonym); Scarus enneacanthus Lacepede; Scarus falcipinnis (Playfair) (Callyodon pindae Smith and C. improvisus Smith are synonyms); Scarus ferrugineus Forsskal (Red Sea and Gulf of Aden; Pseudoscarus augustinus Kossmann and Rauber is a synonym); Scarus festivus Valenciennes (Callyodon lunula Snyder is a synonym); Scarus frenatus Lacepede; Scarus fuscopurpureus (Klunzinger) (Red Sea to Gulf of Oman; Pseudoscarus collana var. eques an Steindachner is a synonym); Scarus ghobban Forsskal (5. lacerta Valenciennes, Callyodon speigleri Smith, and S. fehlmanni Schultz are synonyms), Scarus gibbus Rüppell (Pseudoscarus frontalis Macleay is a synonym and a homonym); Scarus globiceps Valenciennes (S. lepidus Jenyns is a synonym); Scarus niger Forsskal (Pseudoscarus madagascariensis Steindachner is a synonym); Scarus prasiognathos Valenciennes (Maldive Islands appear to the westernmost record; S. chlorodon Jenyns, 5. Singaporensis Bleeker and S. janthochir Bleeker are synonyms); Scarus psittacus Forsskal (5. hertit [Ehrenberg] Valenciennes in C. & V., S. venosus Valenciennes, and S. taeniurus Valenciennes are synonyms); Scarus rubroviolaceus Bleeker (.Pseudoscarus rostratus Gunther is a synonym and a homonym); Scarus russelii Valenciennes (Xanothon fowled Smith is a synonym; initial phase often misidentified as S. venosus)’, Scarus scaber Valenciennes; Scarus sordidus Forsskal (S. spilurus Valenciennes is a synonym, and S. purpureus Valenciennes a synonym and homonym); Scarus tricolor Bleeker (Callyodon mus Smith and C. urbanus Smith are synonyms; initial phase often misidentified as S. Lepidus and the terminal phase as S. pectoralis or S. cyanognathos)’, Scarus viridifucatus (Smith) (Callyodon malindiensis Smith is a synonym), a close relative of S. spinus of the Pacific. Three new species of Scarus are described: S. atrilunula, from Kenya, is in the sordidus complex (initial phase was misidentified as rhoduropterus and the terminal male as capistratoides by Smith, 1956, 1959; S. genazonatus from the Red Sea and Gulf of Aden, also related to S. sordidus, differing chiefly in colour (the most distinctive colour marking of the terminal male is a broad stripe on lower cheek); and S. persicus from the Persian Gulf appears to be related to S. ferrugineus (initial phase light brownish-grey with two rows of small whitish spots on side, and median fin and pelvic fins edged in blue; terminal male similar to that of ferrugineus but with a blackish bar in middle of body). Colour photographs of fresh specimens of all 29 species are presented. Initial and terminal-phase adults are illustrated for most species, and juveniles for some. , Rhodes University Libraries (Digitisation)
- Full Text:
- Date Issued: 1983
Hugh Tracey biographical material
- Irene Frongs (Interviewee), Interviewer unknown, Tracey, Andrew T N
- Authors: Irene Frongs (Interviewee) , Interviewer unknown , Tracey, Andrew T N
- Date: 1983
- Subjects: Tracey, Hugh , Biography , Interviewing , Folklore , Tales , Musical instruments , Sub-Saharan African music
- Language: English
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/113520 , vital:33797 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC133a-01
- Description: Irene Frongs explaining as to how she met Hugh Tracey, first as a student and when she also visited Hugh's farm, discovered that besides music Hugh was interested in other aspects of arts such as foklore, tales, actual handcraft, instruments made, way of living and life for Africans, she also learnt that Hugh vision and goal was not just to build an African Library of music but that it should include the whole cultural aspect of it, found out that Hugh was good at drawing things out instead of talking to you, learnt that Hugh was very good with children no matter what nationality them came from, explained that Hugh was very meticulous and gave more information about Hugh Tracey the man and his interest
- Full Text: false
- Date Issued: 1983
- Authors: Irene Frongs (Interviewee) , Interviewer unknown , Tracey, Andrew T N
- Date: 1983
- Subjects: Tracey, Hugh , Biography , Interviewing , Folklore , Tales , Musical instruments , Sub-Saharan African music
- Language: English
- Type: sound recordings , field recordings , sound recording-musical
- Identifier: http://hdl.handle.net/10962/113520 , vital:33797 , International Library of African Music, Rhodes University, Grahamstown, South Africa , ATC133a-01
- Description: Irene Frongs explaining as to how she met Hugh Tracey, first as a student and when she also visited Hugh's farm, discovered that besides music Hugh was interested in other aspects of arts such as foklore, tales, actual handcraft, instruments made, way of living and life for Africans, she also learnt that Hugh vision and goal was not just to build an African Library of music but that it should include the whole cultural aspect of it, found out that Hugh was good at drawing things out instead of talking to you, learnt that Hugh was very good with children no matter what nationality them came from, explained that Hugh was very meticulous and gave more information about Hugh Tracey the man and his interest
- Full Text: false
- Date Issued: 1983
Comparative bioavailability of some locally manufactured betamethasone valerate containing preparations
- Meyer, Eric, Haigh, John M, Kanfer, Isadore
- Authors: Meyer, Eric , Haigh, John M , Kanfer, Isadore
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6399 , http://hdl.handle.net/10962/d1006326
- Description: The bioavailabilities of three locally manufactured proprietary betamethasone- 17-valerate containing creams and ointments were compared by measuring their abilities to cause blanching of human skin after topical application. The preparations studied were Betnovate Cream and Ointment, Celestoderm-V Cream and Ointment and Persivate Cream and Ointment. Celestoderm-V cream displayed a significantly superior blanching activity over both Betnovate and Persivate creams in' the occluded mode, whereas Persivate cream displayed a significantly superior blanching activity over both Betnovate and Celestoderm-V creams in the unoccluded mode. Persivate ointment was found to produce a significantly superior blanching activity over Betnovate and Celestoderm-V ointments in both the occluded and unoccluded modes of application.
- Full Text:
- Date Issued: 1983
- Authors: Meyer, Eric , Haigh, John M , Kanfer, Isadore
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6399 , http://hdl.handle.net/10962/d1006326
- Description: The bioavailabilities of three locally manufactured proprietary betamethasone- 17-valerate containing creams and ointments were compared by measuring their abilities to cause blanching of human skin after topical application. The preparations studied were Betnovate Cream and Ointment, Celestoderm-V Cream and Ointment and Persivate Cream and Ointment. Celestoderm-V cream displayed a significantly superior blanching activity over both Betnovate and Persivate creams in' the occluded mode, whereas Persivate cream displayed a significantly superior blanching activity over both Betnovate and Celestoderm-V creams in the unoccluded mode. Persivate ointment was found to produce a significantly superior blanching activity over Betnovate and Celestoderm-V ointments in both the occluded and unoccluded modes of application.
- Full Text:
- Date Issued: 1983
I.U.F EDUCATION PROGRAM
- UIF
- Authors: UIF
- Date: 1983
- Subjects: UIF
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/174123 , vital:42444
- Description: THIS IS INFORMATION MATERIAL CONCERNING STUDIES IN STUDY CIRCLES. IT IS AIMED, PRIMARILY, AT BEING A GUIDE TO THOSE WHO HAVE NOT PREVIOUSLY TAKEN PART IN SUCH STUDIES. THE MATERIAL WAS PREPARED BY THE IUF EDUCATION SECRETARIES JOINTLY WITH PARTICIPANTS IN THE IUF STUDY CIRCLE LEADERS' SEMINAR IN THE PHILIPPINES, IN AUTUMN 1981. THE MATERIAL GIVES A THOROUGH INTRODUCTION OF THE STUDY CIRCLE METHOD. IT ALSO DEALS WITH THE ROLE OF THE CIRCLE LEADER AND THE PARTICIPANT AS WELL AS THE REQUIREMENTS OF MATERIAL "DESIGN”.
- Full Text:
- Date Issued: 1983
- Authors: UIF
- Date: 1983
- Subjects: UIF
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/174123 , vital:42444
- Description: THIS IS INFORMATION MATERIAL CONCERNING STUDIES IN STUDY CIRCLES. IT IS AIMED, PRIMARILY, AT BEING A GUIDE TO THOSE WHO HAVE NOT PREVIOUSLY TAKEN PART IN SUCH STUDIES. THE MATERIAL WAS PREPARED BY THE IUF EDUCATION SECRETARIES JOINTLY WITH PARTICIPANTS IN THE IUF STUDY CIRCLE LEADERS' SEMINAR IN THE PHILIPPINES, IN AUTUMN 1981. THE MATERIAL GIVES A THOROUGH INTRODUCTION OF THE STUDY CIRCLE METHOD. IT ALSO DEALS WITH THE ROLE OF THE CIRCLE LEADER AND THE PARTICIPANT AS WELL AS THE REQUIREMENTS OF MATERIAL "DESIGN”.
- Full Text:
- Date Issued: 1983
A victimological study among Coloureds in the Cape Peninsula
- Authors: Strijdom, Hendrik Gert
- Date: 1983
- Subjects: Victims of crimes -- South Africa -- Western Cape Colored people (South Africa) -- Social conditions
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3342 , http://hdl.handle.net/10962/d1004582
- Description: From Introduction: Criminology developed as a reaction to the various revolutions that were occurring in the European countries during the eighteenth and nineteenth centuries. In response to the turmoil and disorder of Western society criminologists attempted to discover the natural laws of society hoping to establish a stable social order. Crime was regarded as something that disturbed society and, therefore, had to be controlled or prevented. According to Quinney and Wildeman (1977) the development of criminology can be viewed as an ongoing attempt to explain crime in terms of established social order. They state that in the history of criminology there is, however, a lack of a clear accumulative theoretical growth and continue as follows: "No line of theoretical development can be found that leads to a well-developed body of knowledge. The study of crime is characterized by a number of divergent theoretical perspectives that exist in relative isolation from one another" (p. 38). Quinney and Wildeman (1977) distinguish five theoretical perspectives in the development of criminology namely: (I) early and classical criminological thought, (2) nineteenth-century sociological criminology, (3) nineteenth-century biological criminology, (4) twentieth-century eclectic criminology, and (5) twentieth-century sociological criminology.
- Full Text:
- Date Issued: 1983
- Authors: Strijdom, Hendrik Gert
- Date: 1983
- Subjects: Victims of crimes -- South Africa -- Western Cape Colored people (South Africa) -- Social conditions
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:3342 , http://hdl.handle.net/10962/d1004582
- Description: From Introduction: Criminology developed as a reaction to the various revolutions that were occurring in the European countries during the eighteenth and nineteenth centuries. In response to the turmoil and disorder of Western society criminologists attempted to discover the natural laws of society hoping to establish a stable social order. Crime was regarded as something that disturbed society and, therefore, had to be controlled or prevented. According to Quinney and Wildeman (1977) the development of criminology can be viewed as an ongoing attempt to explain crime in terms of established social order. They state that in the history of criminology there is, however, a lack of a clear accumulative theoretical growth and continue as follows: "No line of theoretical development can be found that leads to a well-developed body of knowledge. The study of crime is characterized by a number of divergent theoretical perspectives that exist in relative isolation from one another" (p. 38). Quinney and Wildeman (1977) distinguish five theoretical perspectives in the development of criminology namely: (I) early and classical criminological thought, (2) nineteenth-century sociological criminology, (3) nineteenth-century biological criminology, (4) twentieth-century eclectic criminology, and (5) twentieth-century sociological criminology.
- Full Text:
- Date Issued: 1983
Rhodes University Annual Report 1983
- Authors: Rhodes University
- Date: 1983
- Subjects: Rhodes University -- history Rhodes University -- employees Rhodes University -- students
- Language: English
- Identifier: vital:20017
- Full Text:
- Date Issued: 1983
- Authors: Rhodes University
- Date: 1983
- Subjects: Rhodes University -- history Rhodes University -- employees Rhodes University -- students
- Language: English
- Identifier: vital:20017
- Full Text:
- Date Issued: 1983
A price analysis of vegetables on the East London municipal market
- Authors: Fraser, Gavin Cecil Gilbert
- Date: 1983
- Subjects: Agricultural prices -- South Africa
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:1055 , http://hdl.handle.net/10962/d1006970 , Agricultural prices -- South Africa
- Description: [Introduction] Much of the information available on the prices of vegetables marketed through the fresh produce markets is of limited use to producers. This information contains the actual prices for individual years. This can obviously be taken as a guide to future prices but it does not necessarily mean that those prices are a true reflection of the general pattern. In this study an attempt will be made, firstly, to establish whether a general pattern exists in the prices of selected vegetables on the East London municipal market. This will be attempted by studying the prices obtained over the 1964-1979 period. Information of this nature can be used as a basis for the planning of future crops. Secondly, to determine the months which obtain the "best" prices for the selected vegetables taking into account the quantities supplied to the market.
- Full Text:
- Date Issued: 1983
- Authors: Fraser, Gavin Cecil Gilbert
- Date: 1983
- Subjects: Agricultural prices -- South Africa
- Language: English
- Type: Thesis , Masters , MCom
- Identifier: vital:1055 , http://hdl.handle.net/10962/d1006970 , Agricultural prices -- South Africa
- Description: [Introduction] Much of the information available on the prices of vegetables marketed through the fresh produce markets is of limited use to producers. This information contains the actual prices for individual years. This can obviously be taken as a guide to future prices but it does not necessarily mean that those prices are a true reflection of the general pattern. In this study an attempt will be made, firstly, to establish whether a general pattern exists in the prices of selected vegetables on the East London municipal market. This will be attempted by studying the prices obtained over the 1964-1979 period. Information of this nature can be used as a basis for the planning of future crops. Secondly, to determine the months which obtain the "best" prices for the selected vegetables taking into account the quantities supplied to the market.
- Full Text:
- Date Issued: 1983
MAWU and the industrial council
- FOSATU
- Authors: FOSATU
- Date: 1983
- Subjects: FOSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/179221 , vital:39865
- Description: In South Africa at present there are 104 Industrial Councils. However, the one for the Iron, Steel, Engineering and Metallurgical Industries is the largest and most important covering nearly 500 000 workers. But only about 100 000 of these workers belong to trade unions. At the Industrial Council the employers and trade unions negotiate an agreement that covers all 500 000 workers. At present on the union side there are 14 trade unions - M A W U will make it 15. But most of these unions are racial unions and what are called craft unions - that is their members only do certain kinds of jobs e.g. boilermakers or electricians etc. On the employer side nearly all the 8400 factories in the industry are members of the employer association SEIFSA. It is SEIFSA - which is the largest and most powerful employer association in South Africa - that negotiates for employers on the Industrial Council.
- Full Text:
- Date Issued: 1983
- Authors: FOSATU
- Date: 1983
- Subjects: FOSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/179221 , vital:39865
- Description: In South Africa at present there are 104 Industrial Councils. However, the one for the Iron, Steel, Engineering and Metallurgical Industries is the largest and most important covering nearly 500 000 workers. But only about 100 000 of these workers belong to trade unions. At the Industrial Council the employers and trade unions negotiate an agreement that covers all 500 000 workers. At present on the union side there are 14 trade unions - M A W U will make it 15. But most of these unions are racial unions and what are called craft unions - that is their members only do certain kinds of jobs e.g. boilermakers or electricians etc. On the employer side nearly all the 8400 factories in the industry are members of the employer association SEIFSA. It is SEIFSA - which is the largest and most powerful employer association in South Africa - that negotiates for employers on the Industrial Council.
- Full Text:
- Date Issued: 1983
The demand for skilled labour in the Border, Ciskei, Southern Transkei regional economy
- Authors: McCartan, P J
- Date: 1983
- Subjects: Working class -- South Africa Cape of Good Hope (South Africa) -- Economic conditions Good hope plan Border (Eastern Cape, South Africa) Ciskei (South Africa) -- Economic conditions Transkei (South Africa) -- Economic conditions
- Language: English
- Type: Book , Text
- Identifier: http://hdl.handle.net/10962/2112 , vital:20256 , ISBN 0868100587
- Description: The aim of the study is to broadly assess the demand for skilled and semi-skilled labour in the existing industries in that part of Region D of the Good Hope Plan comprising the Border corridor, the Ciskei and southern Transkei (hereafter referred to as the survey region). This survey region was chosen as the target area, since firstly, all of Region D's growth points are located within it and, secondly, technical training facilities in the survey region are recognised as being inadequate. This study does not aim to specify the type of technical training institution that should be established in the survey region; rather it analyses the demand-side of the regional labour market in order to identify the nature and extent of the perceived need for skilled labour. , Digitised by Rhodes University Library on behalf of the Institute of Social and Economic Research (ISER)
- Full Text:
- Date Issued: 1983
- Authors: McCartan, P J
- Date: 1983
- Subjects: Working class -- South Africa Cape of Good Hope (South Africa) -- Economic conditions Good hope plan Border (Eastern Cape, South Africa) Ciskei (South Africa) -- Economic conditions Transkei (South Africa) -- Economic conditions
- Language: English
- Type: Book , Text
- Identifier: http://hdl.handle.net/10962/2112 , vital:20256 , ISBN 0868100587
- Description: The aim of the study is to broadly assess the demand for skilled and semi-skilled labour in the existing industries in that part of Region D of the Good Hope Plan comprising the Border corridor, the Ciskei and southern Transkei (hereafter referred to as the survey region). This survey region was chosen as the target area, since firstly, all of Region D's growth points are located within it and, secondly, technical training facilities in the survey region are recognised as being inadequate. This study does not aim to specify the type of technical training institution that should be established in the survey region; rather it analyses the demand-side of the regional labour market in order to identify the nature and extent of the perceived need for skilled labour. , Digitised by Rhodes University Library on behalf of the Institute of Social and Economic Research (ISER)
- Full Text:
- Date Issued: 1983
Alcoholic adaptation : a preliminary investigation of the transactional analysis viewpoint, with application to delta and gamma alcoholics
- Authors: Cohen, L Derek
- Date: 1983
- Subjects: Alcoholism Alcoholism -- Case studies
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:3193 , http://hdl.handle.net/10962/d1008559
- Description: Two delta and two gamma alcoholics were assessed by case study according to the theoretical formulations of Transactional Analysis. Scripts and Games were elicited through the Thematic Apperception Test, Laddering Procedure, and Life History. Analyses demonstrated, firstly, that parallels were present between the parent-child relationship and present adult transactions; secondly, that needs, fears, and control mechanisms were traceable to early parental injunctions; thirdly, that among these subjects, delta alcoholics tend to play the alcoholic game "Lush", and gamma alcoholics tend to play the alcoholic game "Drunk and Proud". It was concluded that the script and existential position appear to play an important role in the maintenance of the drinking pattern. Alcoholic Loss of Control appears to be influenced by the degree to which aggression is suppressed.
- Full Text:
- Date Issued: 1983
- Authors: Cohen, L Derek
- Date: 1983
- Subjects: Alcoholism Alcoholism -- Case studies
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:3193 , http://hdl.handle.net/10962/d1008559
- Description: Two delta and two gamma alcoholics were assessed by case study according to the theoretical formulations of Transactional Analysis. Scripts and Games were elicited through the Thematic Apperception Test, Laddering Procedure, and Life History. Analyses demonstrated, firstly, that parallels were present between the parent-child relationship and present adult transactions; secondly, that needs, fears, and control mechanisms were traceable to early parental injunctions; thirdly, that among these subjects, delta alcoholics tend to play the alcoholic game "Lush", and gamma alcoholics tend to play the alcoholic game "Drunk and Proud". It was concluded that the script and existential position appear to play an important role in the maintenance of the drinking pattern. Alcoholic Loss of Control appears to be influenced by the degree to which aggression is suppressed.
- Full Text:
- Date Issued: 1983
Continuous-flow dynamic dialysis and its application to collagen-ligand interactions
- Authors: Sparrow, Neil Arthur
- Date: 1983
- Subjects: Collagen Ligands (Biochemistry) Ligand binding (Biochemistry) Protein-protein interactions Tannins
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4297 , http://hdl.handle.net/10962/d1004617
- Description: Studies undertaken to investigate the binding of low molecular mass analogues of polyphenolic vegetable tannins to collagen have prompted the development of a new method to investigate protein-ligand interactions. This method, the continuous-flow dynamic dialysis method (CFDD), differs from conventional dialysis procedures used for protein-ligand binding studies. In this method, the ligand concentration in the diffusate is monitored automatically at successive closely spaced time intervals while being continuously eluted from the dialysis cell. The primary data obtained by this method consists of a series of spectrophotometric absorbance measurements representing the ligand concentration in the sink compartment of a dialysis cell. This primary data is recorded by means of a data logging device onto a punched paper tape for subsequent computer processing. Two original methods are presented for analysing the primary data to extract the protein-ligand binding isotherm. The first of these is a direct analysis which relies on Fick's first law of diffusion. In this method it is necessary to establish, by means of a control experiment, a value for the ligand permeation constant. This is used in a subsequent analysis to establish a relationship between the measured rate of diffusion of the ligand from a protein-ligand mixture and the concentration of unbound ligand which is in equilibrium with the protein-ligand complex. The protein-ligand binding isotherm is obtained from parametric equations which give the quantity of ligand bound to the protein and the concentration of unbound ligand in the sample compartment as functions of time. The second method, which is more general, utilizes the same primary data but is based on establishing a system transfer function to characterise the dialysis and eluting processes. This analysis depends on the linearity of the system and utilizes numerical laplace transforms of the primary data sets obtained from control and protein-ligand dialyses. Laplace transforms are used to effect a deconvolution of the transfer function from the primary data and yield the concentration of ligand in equilibrium with the protein-ligand complex. This procedure yields, simultaneously, both the total ligand concentration and the concentration of unbound ligand in the protein compartment of the dialysis cell. These quantities are used to establish the binding isotherm for the protein ligand system. Numerical inversion of the laplace transforms in this analysis is effected by their reduction to Fourier series. The experimental reliability of the continuous-flow dynamic dialysis method, and validity of the two analytical methods used to derive a binding isotherm from dialysis data are evaluated from studies of the binding of phenol red to bovine serum albumin (BSA) at 15⁰, 20⁰ and 25⁰ C, as well as from simulated binding curves generated by the numerical solution of the differential equations used to describe the dialysis and elution process in terms of a two-site Scatchard binding model. The method is used to investigate the binding to collagen of a series of low molecular mass phenolic compounds which can be isolated from Wattle and Quebracho vegetable tannin extracts. These compounds can be considered as monomeric precursor analogues of the polymeric vegetable tannins. The binding of these ligands to collagen is shown to be characterised by high capacity, low affinity binding in which the uptake of ligand by the protein increases linearly with increasing ligand concentration. Collagen exhibits no indication of site saturation for these ligands over the experimentally accessible concentration ranges investigated.
- Full Text:
- Date Issued: 1983
- Authors: Sparrow, Neil Arthur
- Date: 1983
- Subjects: Collagen Ligands (Biochemistry) Ligand binding (Biochemistry) Protein-protein interactions Tannins
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:4297 , http://hdl.handle.net/10962/d1004617
- Description: Studies undertaken to investigate the binding of low molecular mass analogues of polyphenolic vegetable tannins to collagen have prompted the development of a new method to investigate protein-ligand interactions. This method, the continuous-flow dynamic dialysis method (CFDD), differs from conventional dialysis procedures used for protein-ligand binding studies. In this method, the ligand concentration in the diffusate is monitored automatically at successive closely spaced time intervals while being continuously eluted from the dialysis cell. The primary data obtained by this method consists of a series of spectrophotometric absorbance measurements representing the ligand concentration in the sink compartment of a dialysis cell. This primary data is recorded by means of a data logging device onto a punched paper tape for subsequent computer processing. Two original methods are presented for analysing the primary data to extract the protein-ligand binding isotherm. The first of these is a direct analysis which relies on Fick's first law of diffusion. In this method it is necessary to establish, by means of a control experiment, a value for the ligand permeation constant. This is used in a subsequent analysis to establish a relationship between the measured rate of diffusion of the ligand from a protein-ligand mixture and the concentration of unbound ligand which is in equilibrium with the protein-ligand complex. The protein-ligand binding isotherm is obtained from parametric equations which give the quantity of ligand bound to the protein and the concentration of unbound ligand in the sample compartment as functions of time. The second method, which is more general, utilizes the same primary data but is based on establishing a system transfer function to characterise the dialysis and eluting processes. This analysis depends on the linearity of the system and utilizes numerical laplace transforms of the primary data sets obtained from control and protein-ligand dialyses. Laplace transforms are used to effect a deconvolution of the transfer function from the primary data and yield the concentration of ligand in equilibrium with the protein-ligand complex. This procedure yields, simultaneously, both the total ligand concentration and the concentration of unbound ligand in the protein compartment of the dialysis cell. These quantities are used to establish the binding isotherm for the protein ligand system. Numerical inversion of the laplace transforms in this analysis is effected by their reduction to Fourier series. The experimental reliability of the continuous-flow dynamic dialysis method, and validity of the two analytical methods used to derive a binding isotherm from dialysis data are evaluated from studies of the binding of phenol red to bovine serum albumin (BSA) at 15⁰, 20⁰ and 25⁰ C, as well as from simulated binding curves generated by the numerical solution of the differential equations used to describe the dialysis and elution process in terms of a two-site Scatchard binding model. The method is used to investigate the binding to collagen of a series of low molecular mass phenolic compounds which can be isolated from Wattle and Quebracho vegetable tannin extracts. These compounds can be considered as monomeric precursor analogues of the polymeric vegetable tannins. The binding of these ligands to collagen is shown to be characterised by high capacity, low affinity binding in which the uptake of ligand by the protein increases linearly with increasing ligand concentration. Collagen exhibits no indication of site saturation for these ligands over the experimentally accessible concentration ranges investigated.
- Full Text:
- Date Issued: 1983
The geological evolution and mineralised environments of the Tasman Geosyncline
- Authors: Pelham, D A
- Date: 1983 , 2013-04-03
- Subjects: Geosynclines -- Tasmania , Geology -- Tasmania , Ore deposits -- Tasmania , Mineralogy -- Tasmania
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5030 , http://hdl.handle.net/10962/d1006936 , Geosynclines -- Tasmania , Geology -- Tasmania , Ore deposits -- Tasmania , Mineralogy -- Tasmania
- Description: From introduction: The Tasman Geosyncline covers the eastern part of the continent of Australia, an area of over 2 million km'. The area has been a major source of Australian gold and tin production, and though it contains important base metal sulphide deposits, these are overshadowed in scale by the very large stratabound Proterozoic deposits (for example, Mt Isa, Broken Hill and McArthur River). This dissertation deals with the metallic mineral deposits of the Tasman Geosyncline, and as such does not include the extensive post Palaeozoic continental successions, with their important coal reserves, that overlie the deformed geosyncl i nal sequences.
- Full Text:
- Date Issued: 1983
- Authors: Pelham, D A
- Date: 1983 , 2013-04-03
- Subjects: Geosynclines -- Tasmania , Geology -- Tasmania , Ore deposits -- Tasmania , Mineralogy -- Tasmania
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5030 , http://hdl.handle.net/10962/d1006936 , Geosynclines -- Tasmania , Geology -- Tasmania , Ore deposits -- Tasmania , Mineralogy -- Tasmania
- Description: From introduction: The Tasman Geosyncline covers the eastern part of the continent of Australia, an area of over 2 million km'. The area has been a major source of Australian gold and tin production, and though it contains important base metal sulphide deposits, these are overshadowed in scale by the very large stratabound Proterozoic deposits (for example, Mt Isa, Broken Hill and McArthur River). This dissertation deals with the metallic mineral deposits of the Tasman Geosyncline, and as such does not include the extensive post Palaeozoic continental successions, with their important coal reserves, that overlie the deformed geosyncl i nal sequences.
- Full Text:
- Date Issued: 1983
Phenylpropanolamine hydrochloride
- Kanfer, Isadore, Haigh, John M, Dowse, Roslind
- Authors: Kanfer, Isadore , Haigh, John M , Dowse, Roslind
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6385 , http://hdl.handle.net/10962/d1006306
- Description: Phenylpropanolamine hydrochloride belongs to the sympathomimetic amine class of drugs and is structurally related to ephedrine hydrochloride. Its synthesis was first reported in 1910 and the first American patent was registered in 1939. The effects of phenylpropanolamine hydrochloride are largely the result of alpha-adrenergic agonist activity resulting from both direct stimulation of adrenergic receptors and release of neuronal norepinephrine. The principal adverse effect of phenylpropanolamine hydrochloride is dose-related hypertension and ventricular arrhythmia has been described. Phenylpropanolamine hydrochloride is widely used as a decongestant and it has been used as an anorectic agent for over 40 years. A report in 1939 described its effect as an hypertensive agent when administered parenterally.
- Full Text:
- Date Issued: 1983
- Authors: Kanfer, Isadore , Haigh, John M , Dowse, Roslind
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6385 , http://hdl.handle.net/10962/d1006306
- Description: Phenylpropanolamine hydrochloride belongs to the sympathomimetic amine class of drugs and is structurally related to ephedrine hydrochloride. Its synthesis was first reported in 1910 and the first American patent was registered in 1939. The effects of phenylpropanolamine hydrochloride are largely the result of alpha-adrenergic agonist activity resulting from both direct stimulation of adrenergic receptors and release of neuronal norepinephrine. The principal adverse effect of phenylpropanolamine hydrochloride is dose-related hypertension and ventricular arrhythmia has been described. Phenylpropanolamine hydrochloride is widely used as a decongestant and it has been used as an anorectic agent for over 40 years. A report in 1939 described its effect as an hypertensive agent when administered parenterally.
- Full Text:
- Date Issued: 1983