A stability-indicating high performance liquid chromatographic assay for the determination of orlistat in capsules
- Mohammadi, Ali, Haririan, I, Rezanour, Nasrin, Ghiasi, L, Walker, Roderick B
- Authors: Mohammadi, Ali , Haririan, I , Rezanour, Nasrin , Ghiasi, L , Walker, Roderick B
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184267 , vital:44195 , xlink:href="https://doi.org/10.1016/j.chroma.2006.03.038"
- Description: A stability-indicating HPLC method was developed and validated for the quantitative determination of orlistat in capsule dosage forms. An isocratic separation was achieved using a Perfectsil® target ODS-3, 250 mm × 4.6 mm i.d., 5 μm particle size column with a flow rate of 0.7 ml/min and using a UV detector to monitor the eluate at 210 nm. The mobile phase consisted of methanol:acetonitrile:trifluoroacetic acid (82.5:17.5:0.01, v/v/v). The drug was subjected oxidation, hydrolysis, photolysis and heat to apply stress conditions. Complete separation was achieved for the parent compound and all degradation products in an overall analytical run time of approximately 15 min with the parent compound orlistat eluting at approximately 9 min. The method was linear over the concentration range of 0.02–0.75 mg/ml (r = 0.9998) with a limit of detection and quantitation 0.006 and 0.02 mg/ml, respectively. The method has the requisite accuracy, selectivity, sensitivity and precision to assay orlistat in capsules. Degradation products resulting from the stress studies did not interfere with the detection of orlistat and the assay is thus stability-indicating.
- Full Text:
- Date Issued: 2006
- Authors: Mohammadi, Ali , Haririan, I , Rezanour, Nasrin , Ghiasi, L , Walker, Roderick B
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184267 , vital:44195 , xlink:href="https://doi.org/10.1016/j.chroma.2006.03.038"
- Description: A stability-indicating HPLC method was developed and validated for the quantitative determination of orlistat in capsule dosage forms. An isocratic separation was achieved using a Perfectsil® target ODS-3, 250 mm × 4.6 mm i.d., 5 μm particle size column with a flow rate of 0.7 ml/min and using a UV detector to monitor the eluate at 210 nm. The mobile phase consisted of methanol:acetonitrile:trifluoroacetic acid (82.5:17.5:0.01, v/v/v). The drug was subjected oxidation, hydrolysis, photolysis and heat to apply stress conditions. Complete separation was achieved for the parent compound and all degradation products in an overall analytical run time of approximately 15 min with the parent compound orlistat eluting at approximately 9 min. The method was linear over the concentration range of 0.02–0.75 mg/ml (r = 0.9998) with a limit of detection and quantitation 0.006 and 0.02 mg/ml, respectively. The method has the requisite accuracy, selectivity, sensitivity and precision to assay orlistat in capsules. Degradation products resulting from the stress studies did not interfere with the detection of orlistat and the assay is thus stability-indicating.
- Full Text:
- Date Issued: 2006
Accuracy of the activation energy calculated from a thermoluminescence glow‐peak using a method that uses three points on the peak
- Ogundare, F O, Chithambo, Makaiko L
- Authors: Ogundare, F O , Chithambo, Makaiko L
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123016 , vital:35397 , https://doi:10.1002/pssc.200521077
- Description: The utility of thermoluminescence (TL) in detecting changes in defect concentration in insulators is well established [1–3]. The underlying premise leading to the emission of TL is that exposure of a material to ionizing radiation causes a redistribution of charge in defect centres within the material. When the material is heated at a controlled linear rate, the thermoluminescence is emitted as a temperature-dependent set of peaks collectively known as a glow-curve. The shape and intensity of each of the glow-peaks may be characterized by a set of parameters consisting of the activation energy E, the frequency factors, the number of electrons n0 trapped in defect centres at the start of the heating, and the order of kinetics b. The order of kinetics b is an indication of the retrapping probability i.e. the probability that a free electron from the conduction band will be retrapped rather than recombine with a hole at a recombination centre to produce thermoluminescence. Retrapping of electrons reduces the TL intensity at any particular temperature during the heating process. The physical mechanisms of TL associated with a given glow curve are unique and may be characterized by analysis of the glow-curve for the said kinetic parameters.
- Full Text:
- Date Issued: 2006
- Authors: Ogundare, F O , Chithambo, Makaiko L
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/123016 , vital:35397 , https://doi:10.1002/pssc.200521077
- Description: The utility of thermoluminescence (TL) in detecting changes in defect concentration in insulators is well established [1–3]. The underlying premise leading to the emission of TL is that exposure of a material to ionizing radiation causes a redistribution of charge in defect centres within the material. When the material is heated at a controlled linear rate, the thermoluminescence is emitted as a temperature-dependent set of peaks collectively known as a glow-curve. The shape and intensity of each of the glow-peaks may be characterized by a set of parameters consisting of the activation energy E, the frequency factors, the number of electrons n0 trapped in defect centres at the start of the heating, and the order of kinetics b. The order of kinetics b is an indication of the retrapping probability i.e. the probability that a free electron from the conduction band will be retrapped rather than recombine with a hole at a recombination centre to produce thermoluminescence. Retrapping of electrons reduces the TL intensity at any particular temperature during the heating process. The physical mechanisms of TL associated with a given glow curve are unique and may be characterized by analysis of the glow-curve for the said kinetic parameters.
- Full Text:
- Date Issued: 2006
Actor/actant-network theory as emerging methodology for environmental education research in southern Africa
- Authors: Nhamo, Godwell
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/373553 , vital:66701 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/122722"
- Description: This paper deliberates on actor/actant-network theory (AANT) as methodology for policy research in environmental education (EE). Insights are drawn from work that applied AANT to research environmental policy processes surrounding the formulation and implementation of South Africa’s Plastic Bags Regulations of 2003. The paper reveals that the application of AANT methodology made it possible to trace relationships, actors, actants and actor/actant-networks surrounding the Plastic Bags Regulations as quasi-object (token). The methodology also enabled a focus on understanding and investigating tensions, debates and responses emerging from the policy process. The findings were that after the promulgation of the first draft of the Plastic Bags Regulations in May 2000, tensions emerged around the nature of regulation (whether to use the command and control approach – preferred by Organised Government – or self regulation – preferred by Organised Business and Organised Labour). From these findings, a series of conceptual frameworks were drawn up as identified around key actors and actor/actant-networks. The conceptual frameworks included among them, Organised Government, Organised Business and Organised Labour.
- Full Text: false
- Date Issued: 2006
- Authors: Nhamo, Godwell
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/373553 , vital:66701 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/122722"
- Description: This paper deliberates on actor/actant-network theory (AANT) as methodology for policy research in environmental education (EE). Insights are drawn from work that applied AANT to research environmental policy processes surrounding the formulation and implementation of South Africa’s Plastic Bags Regulations of 2003. The paper reveals that the application of AANT methodology made it possible to trace relationships, actors, actants and actor/actant-networks surrounding the Plastic Bags Regulations as quasi-object (token). The methodology also enabled a focus on understanding and investigating tensions, debates and responses emerging from the policy process. The findings were that after the promulgation of the first draft of the Plastic Bags Regulations in May 2000, tensions emerged around the nature of regulation (whether to use the command and control approach – preferred by Organised Government – or self regulation – preferred by Organised Business and Organised Labour). From these findings, a series of conceptual frameworks were drawn up as identified around key actors and actor/actant-networks. The conceptual frameworks included among them, Organised Government, Organised Business and Organised Labour.
- Full Text: false
- Date Issued: 2006
Actor/actant-network theory as emerging methodology for environmental education research in southern Africa
- Authors: Nhamo, Godwell
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/373537 , vital:66702 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/122722"
- Description: This paper deliberates on actor/actant-network theory (AANT) as methodology for policy research in environmental education (EE). Insights are drawn from work that applied AANT to research environmental policy processes surrounding the formulation and implementation of South Africa’s Plastic Bags Regulations of 2003. The paper reveals that the application of AANT methodology made it possible to trace relationships, actors, actants and actor/actant-networks surrounding the Plastic Bags Regulations as quasi-object (token). The methodology also enabled a focus on understanding and investigating tensions, debates and responses emerging from the policy process. The findings were that after the promulgation of the first draft of the Plastic Bags Regulations in May 2000, tensions emerged around the nature of regulation (whether to use the command and control approach – preferred by Organised Government – or self regulation – preferred by Organised Business and Organised Labour). From these findings, a series of conceptual frameworks were drawn up as identified around key actors and actor/actant-networks. The conceptual frameworks included among them, Organised Government, Organised Business and Organised Labour.
- Full Text:
- Date Issued: 2006
- Authors: Nhamo, Godwell
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/373537 , vital:66702 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/122722"
- Description: This paper deliberates on actor/actant-network theory (AANT) as methodology for policy research in environmental education (EE). Insights are drawn from work that applied AANT to research environmental policy processes surrounding the formulation and implementation of South Africa’s Plastic Bags Regulations of 2003. The paper reveals that the application of AANT methodology made it possible to trace relationships, actors, actants and actor/actant-networks surrounding the Plastic Bags Regulations as quasi-object (token). The methodology also enabled a focus on understanding and investigating tensions, debates and responses emerging from the policy process. The findings were that after the promulgation of the first draft of the Plastic Bags Regulations in May 2000, tensions emerged around the nature of regulation (whether to use the command and control approach – preferred by Organised Government – or self regulation – preferred by Organised Business and Organised Labour). From these findings, a series of conceptual frameworks were drawn up as identified around key actors and actor/actant-networks. The conceptual frameworks included among them, Organised Government, Organised Business and Organised Labour.
- Full Text:
- Date Issued: 2006
Alternative media: a viable option for Southern Africa?
- Authors: Banda, Fackson
- Date: 2006
- Language: English
- Type: text , article
- Identifier: vital:6328 , http://hdl.handle.net/10962/d1008473 , https://core.ac.uk/download/pdf/145046852.pdf
- Description: preprint , The article attempts a historically and culturally based definition of alternative media. It then gives some case studies to illustrate the efficacy of such media forms, apart from highlighting the problems associated with them. It concludes that alternative media emerge to deal with specific ideological projects and, as such, must be viewed as satisfying a specific need at a specific point in time.
- Full Text:
- Date Issued: 2006
- Authors: Banda, Fackson
- Date: 2006
- Language: English
- Type: text , article
- Identifier: vital:6328 , http://hdl.handle.net/10962/d1008473 , https://core.ac.uk/download/pdf/145046852.pdf
- Description: preprint , The article attempts a historically and culturally based definition of alternative media. It then gives some case studies to illustrate the efficacy of such media forms, apart from highlighting the problems associated with them. It concludes that alternative media emerge to deal with specific ideological projects and, as such, must be viewed as satisfying a specific need at a specific point in time.
- Full Text:
- Date Issued: 2006
AmaNdebele, Peter Magubane and Sandra Klopper: book review
- Authors: Simbao, Ruth K
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147336 , vital:38627 , https://0-hdl.handle.net.wam.seals.ac.za/10520/EJC31002
- Description: AmaNdebele is a very attractive book with beautifully reproduced colour photographs taken by the renowned photographer Peter Magubane, who secured enormous credibility as a photojournalist during the violent years of apartheid. While some South African readers who browse through the glossy portrayals of ceremonial attire and homestead decorations may recall Magubane's earlier books such as Soweto speaks (1981) and Soweto: The fruit of fear (1986) in which the photographer laid bare the ferocious violence of apartheid rule, many readers will skip over the nuances of both Magubane's disrupted career and the contentious relationship between the Ndebele people and the South African apartheid government.
- Full Text:
- Date Issued: 2006
- Authors: Simbao, Ruth K
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147336 , vital:38627 , https://0-hdl.handle.net.wam.seals.ac.za/10520/EJC31002
- Description: AmaNdebele is a very attractive book with beautifully reproduced colour photographs taken by the renowned photographer Peter Magubane, who secured enormous credibility as a photojournalist during the violent years of apartheid. While some South African readers who browse through the glossy portrayals of ceremonial attire and homestead decorations may recall Magubane's earlier books such as Soweto speaks (1981) and Soweto: The fruit of fear (1986) in which the photographer laid bare the ferocious violence of apartheid rule, many readers will skip over the nuances of both Magubane's disrupted career and the contentious relationship between the Ndebele people and the South African apartheid government.
- Full Text:
- Date Issued: 2006
An Exploration of How Natural Resource Management (NRM) Discourse is Integrated into Key Pedagogic Texts
- Authors: Nsubuga, Yvonne
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/373552 , vital:66703 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/122753"
- Description: Natural resource management (NRM) education has the potential to improve the quality and relevance of rural education in South Africa. For this potential to be realised, the various educational resources that are commonly used by teachers and learners in rural schools need to incorporate natural resource management knowledge. Using Bernstein’s concepts of classification and his theories on recontextualisation, a content analysis study was carried out to compare the level of NRM integration within the Grade 10 Life Sciences syllabus, and a Grade 10 Life Sciences textbook. Results from the analysis of the syllabus showed that overall only 9% of all the knowledge statements analysed had a strong link to NRM and related issues. The highest percentage of such sentences was found in the Core Knowledge section of the syllabus (21%). For the textbook, only 8% of the analysed items had a strong link to NRM and related issues, with the highest percentage of such items occurring in the Suggested Activities section (16%). However, the level of NRM integration in both documents increased considerably when sentences that had only an implicit link to NRM and related issues were included. It was concluded that both documents provide ample opportunities for NRM learning, although the extent to which this occurs varies among their different sections. The recontextualising role of the Grade 10 Life Sciences textbook was reflected in its relatively higher level of NRM integration in the Suggested Activities category, and in the Glossary category. This study highlights the need for further strengthening of the position of NRM within the Grade 10 Life Sciences syllabus, and for more Bernstein-based research to inform South Africa’s curriculum reform initiatives in environmental education.
- Full Text:
- Date Issued: 2006
- Authors: Nsubuga, Yvonne
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/373552 , vital:66703 , xlink:href="https://www.ajol.info/index.php/sajee/article/view/122753"
- Description: Natural resource management (NRM) education has the potential to improve the quality and relevance of rural education in South Africa. For this potential to be realised, the various educational resources that are commonly used by teachers and learners in rural schools need to incorporate natural resource management knowledge. Using Bernstein’s concepts of classification and his theories on recontextualisation, a content analysis study was carried out to compare the level of NRM integration within the Grade 10 Life Sciences syllabus, and a Grade 10 Life Sciences textbook. Results from the analysis of the syllabus showed that overall only 9% of all the knowledge statements analysed had a strong link to NRM and related issues. The highest percentage of such sentences was found in the Core Knowledge section of the syllabus (21%). For the textbook, only 8% of the analysed items had a strong link to NRM and related issues, with the highest percentage of such items occurring in the Suggested Activities section (16%). However, the level of NRM integration in both documents increased considerably when sentences that had only an implicit link to NRM and related issues were included. It was concluded that both documents provide ample opportunities for NRM learning, although the extent to which this occurs varies among their different sections. The recontextualising role of the Grade 10 Life Sciences textbook was reflected in its relatively higher level of NRM integration in the Suggested Activities category, and in the Glossary category. This study highlights the need for further strengthening of the position of NRM within the Grade 10 Life Sciences syllabus, and for more Bernstein-based research to inform South Africa’s curriculum reform initiatives in environmental education.
- Full Text:
- Date Issued: 2006
Bioequivalence assessment of generic products an innovative South African approach
- Walker, Roderick B, Kanfer, Isadore, Skinner, Michael F
- Authors: Walker, Roderick B , Kanfer, Isadore , Skinner, Michael F
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184256 , vital:44194 , xlink:href="https://doi.org/10.1080/10601330500534014"
- Description: Concurrent with the implementation of new legislation mandating Generic Substitution in South Africa, a new set of guidelines for bioavailability and bioequivalence have been published. Since one of the main objectives of the new legislation in South Africa relating to Generic Substitution is to ensure that medicines of high quality, safety, and efficacy are made more accessible and more affordable to the wider public, the need to speed up approval of such multi-source products has become a regulatory priority. In order to facilitate this process, various bioequivalence issues have been addressed including important issues such as the acceptance criteria and associated bioequivalence intervals, use of a foreign reference product and the issue of assessing highly variable drugs (HVDs). In addition, dispensations have been made with respect to food effect assessment and variability relating to genetic polymorphism in drug metabolism (genotyping/phenotyping). Furthermore, the use of “old” biostudies submitted in support of an application is subject to expiry date. Acceptance of appropriate data requires that specific criteria such as Cmax and AUC, in addition to the usual considerations, also meet the limits specified by the particular registration authority of the country where such products are intended to be marketed. Generally, these limits require that the 90% confidence interval (CI) for AUC and Cmax test/reference ratios lies within the acceptance interval of 0.80–1.25 calculated using log-transformed data. While such acceptance criteria are, in general, ubiquitous, some differences in acceptance criteria do exist between various countries. The new guidelines for bioavailability/bioequivalence studies developed by the South African regulatory authority, the Medicines Control Council (MCC), makes provision for highly variable drugs and the use of a non-South African reference product. The MCC requires that the acceptance criterion for Cmax ratios be set at 0.75–1.33 while maintaining AUC ratios at 0.80–1.25 using a 90% CI. Furthermore, provision is made to apply scaling based on average bioequivalence assessment and, as an interim measure, consideration has also been given to the use of a foreign reference product provided that equivalence between that product and the innovator product currently available on the South African market can be shown using in vitro testing.
- Full Text:
- Date Issued: 2006
- Authors: Walker, Roderick B , Kanfer, Isadore , Skinner, Michael F
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/184256 , vital:44194 , xlink:href="https://doi.org/10.1080/10601330500534014"
- Description: Concurrent with the implementation of new legislation mandating Generic Substitution in South Africa, a new set of guidelines for bioavailability and bioequivalence have been published. Since one of the main objectives of the new legislation in South Africa relating to Generic Substitution is to ensure that medicines of high quality, safety, and efficacy are made more accessible and more affordable to the wider public, the need to speed up approval of such multi-source products has become a regulatory priority. In order to facilitate this process, various bioequivalence issues have been addressed including important issues such as the acceptance criteria and associated bioequivalence intervals, use of a foreign reference product and the issue of assessing highly variable drugs (HVDs). In addition, dispensations have been made with respect to food effect assessment and variability relating to genetic polymorphism in drug metabolism (genotyping/phenotyping). Furthermore, the use of “old” biostudies submitted in support of an application is subject to expiry date. Acceptance of appropriate data requires that specific criteria such as Cmax and AUC, in addition to the usual considerations, also meet the limits specified by the particular registration authority of the country where such products are intended to be marketed. Generally, these limits require that the 90% confidence interval (CI) for AUC and Cmax test/reference ratios lies within the acceptance interval of 0.80–1.25 calculated using log-transformed data. While such acceptance criteria are, in general, ubiquitous, some differences in acceptance criteria do exist between various countries. The new guidelines for bioavailability/bioequivalence studies developed by the South African regulatory authority, the Medicines Control Council (MCC), makes provision for highly variable drugs and the use of a non-South African reference product. The MCC requires that the acceptance criterion for Cmax ratios be set at 0.75–1.33 while maintaining AUC ratios at 0.80–1.25 using a 90% CI. Furthermore, provision is made to apply scaling based on average bioequivalence assessment and, as an interim measure, consideration has also been given to the use of a foreign reference product provided that equivalence between that product and the innovator product currently available on the South African market can be shown using in vitro testing.
- Full Text:
- Date Issued: 2006
Cognitive pharmaceutical services and the community pharmacist: are South African patients receiving them and are they willing to pay?
- Hill, Peter W, Dowse, Roslind
- Authors: Hill, Peter W , Dowse, Roslind
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156829 , vital:40054 , DOI 10.1211/ijpp.15.2.0007
- Description: The objectives of this study were to ascertain the opinions of randomly selected South African medical aid members regarding the provision by community pharmacists of patient counselling and information; member satisfaction with pharmacist services; their rating of pharmacist accessibility; and if pharmacists should be reimbursed for providing cognitive pharmaceutical services. Setting A South African private healthcare insurance company.
- Full Text:
- Date Issued: 2006
- Authors: Hill, Peter W , Dowse, Roslind
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156829 , vital:40054 , DOI 10.1211/ijpp.15.2.0007
- Description: The objectives of this study were to ascertain the opinions of randomly selected South African medical aid members regarding the provision by community pharmacists of patient counselling and information; member satisfaction with pharmacist services; their rating of pharmacist accessibility; and if pharmacists should be reimbursed for providing cognitive pharmaceutical services. Setting A South African private healthcare insurance company.
- Full Text:
- Date Issued: 2006
Commentary: Negotiating distant influences: globalization and broadcasting policy reforms in Zambia and South Africa
- Authors: Banda, Fackson
- Date: 2006
- Language: English
- Type: text , article
- Identifier: vital:6325 , http://hdl.handle.net/10962/d1008299 , https://doi.org/10.22230/cjc.2006v31n2a1785
- Description: preprint , This commentary looks at the influences of globalisation on broadcasting policy reforms in Zambia and South Africa, with specific focus on such processes as deregulation, privatisation, commercialisation, communitarianism and technological convergence. It concludes that globalisation does not affect southern African countries uniformly; rather, it is refracted in accordance with the different cultural and political experiences of such countries.
- Full Text:
- Date Issued: 2006
- Authors: Banda, Fackson
- Date: 2006
- Language: English
- Type: text , article
- Identifier: vital:6325 , http://hdl.handle.net/10962/d1008299 , https://doi.org/10.22230/cjc.2006v31n2a1785
- Description: preprint , This commentary looks at the influences of globalisation on broadcasting policy reforms in Zambia and South Africa, with specific focus on such processes as deregulation, privatisation, commercialisation, communitarianism and technological convergence. It concludes that globalisation does not affect southern African countries uniformly; rather, it is refracted in accordance with the different cultural and political experiences of such countries.
- Full Text:
- Date Issued: 2006
Comparative efficiency of immobilized non-transition metal phthalocyanine photosensitizers for the visible light transformation of chlorophenols
- Agboola, Bolade, Ozoemena, Kenneth I, Nyokong, Tebello
- Authors: Agboola, Bolade , Ozoemena, Kenneth I , Nyokong, Tebello
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/286043 , vital:56233 , xlink:href="https://doi.org/10.1016/j.molcata.2005.12.009"
- Description: Photolysis of aqueous solutions of chlorophenols (4-chlorophenol, 2,4-dichlorophenol, 2,4,5-trichlorophenol and pentachlorophenol) in the presence of immobilized non-transition metal phthalocyanine photosensitizers onto Amberlite® is presented. The photosensitizers studied are: Al (AlOCPc) and Zn (ZnOCPc) octacarboxyphthalocyanines; Al (AlPcS4) and Zn (ZnPcS4) tetrasulfophthalocyanines; sulfonated phthalocyanine complexes (containing mixtures of differently substituted derivatives) of Al (AlPcSmix), Zn (ZnPcSmix), Ge (GePcSmix), Si (SiPcSmix) and Sn (SnPcSmix). Photolysis of the chlorophenols resulted mainly in the formation of chlorobenzoquinone derivatives. The complexes showed order of activity towards the transformation of pentachlorophenol as follows: ZnOCPc > SiPcSmix > SnPcSmix > ZnPcSmix > GePcSmix > ZnPcS4 > AlPcSmix > AlOCPc > AlPcS4. The generation of singlet oxygen (1O2) by these immobilized MPc photosensitizers was found to play a major role in their photoactivities towards the transformation of these chlorophenols. Langmuir–Hinshelwood (L–H) kinetic model studies showed that the ZnOCPc, GePcSmix and ZnPcSmix photocatalysis occurred on the catalysts surface. © 2005 Elsevier B.V. All rights reserved.
- Full Text:
- Date Issued: 2006
- Authors: Agboola, Bolade , Ozoemena, Kenneth I , Nyokong, Tebello
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/286043 , vital:56233 , xlink:href="https://doi.org/10.1016/j.molcata.2005.12.009"
- Description: Photolysis of aqueous solutions of chlorophenols (4-chlorophenol, 2,4-dichlorophenol, 2,4,5-trichlorophenol and pentachlorophenol) in the presence of immobilized non-transition metal phthalocyanine photosensitizers onto Amberlite® is presented. The photosensitizers studied are: Al (AlOCPc) and Zn (ZnOCPc) octacarboxyphthalocyanines; Al (AlPcS4) and Zn (ZnPcS4) tetrasulfophthalocyanines; sulfonated phthalocyanine complexes (containing mixtures of differently substituted derivatives) of Al (AlPcSmix), Zn (ZnPcSmix), Ge (GePcSmix), Si (SiPcSmix) and Sn (SnPcSmix). Photolysis of the chlorophenols resulted mainly in the formation of chlorobenzoquinone derivatives. The complexes showed order of activity towards the transformation of pentachlorophenol as follows: ZnOCPc > SiPcSmix > SnPcSmix > ZnPcSmix > GePcSmix > ZnPcS4 > AlPcSmix > AlOCPc > AlPcS4. The generation of singlet oxygen (1O2) by these immobilized MPc photosensitizers was found to play a major role in their photoactivities towards the transformation of these chlorophenols. Langmuir–Hinshelwood (L–H) kinetic model studies showed that the ZnOCPc, GePcSmix and ZnPcSmix photocatalysis occurred on the catalysts surface. © 2005 Elsevier B.V. All rights reserved.
- Full Text:
- Date Issued: 2006
Comparative electrochemistry and electrocatalytic activities of cobalt, iron and manganese phthalocyanine complexes axially co-ordinated to mercaptopyridine self-assembled monolayer at gold electrodes
- Ozoemena, Kenneth I, Nyokong, Tebello
- Authors: Ozoemena, Kenneth I , Nyokong, Tebello
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/286054 , vital:56234 , xlink:href="https://doi.org/10.1016/j.electacta.2005.08.007"
- Description: Comparative surface electrochemistry and electrocatalytic properties of solid ultrathin monolayer films of metallophthalocyanine (MPc) complexes of cobalt (CoPc), iron (FePc) and manganese (MnPc) self-immobilised, via axial ligation reaction, onto preformed 4-mercaptopyridine self-assembled monolayers (SAMs) on gold electrodes have been described. Surface electrochemical parameters of the modified electrodes showed that these MPc-SAMs are densely packed with flat orientations. The electrochemical, electrocatalytic and stability properties of these MPc complexes follow this order: FePc > MnPc > CoPc. This finding is remarkable as it suggests that the success of using this method of self-assembling of MPc onto gold electrode is largely dependent on the bond distance between the pyridine linker and the central metal of the MPc; the shorter the distance, the faster the co-ordination and the better the electrocatalytic properties towards L-cysteine and thiocyanate. Thus, the superiority of FePc-based SAM over those of the MnPc and CoPc, has been proposed to be the result of the more favorable axial co-ordination properties of FePc with pyridine (i.e. shorter Fe–N(pyridine) bond length.
- Full Text:
- Date Issued: 2006
- Authors: Ozoemena, Kenneth I , Nyokong, Tebello
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/286054 , vital:56234 , xlink:href="https://doi.org/10.1016/j.electacta.2005.08.007"
- Description: Comparative surface electrochemistry and electrocatalytic properties of solid ultrathin monolayer films of metallophthalocyanine (MPc) complexes of cobalt (CoPc), iron (FePc) and manganese (MnPc) self-immobilised, via axial ligation reaction, onto preformed 4-mercaptopyridine self-assembled monolayers (SAMs) on gold electrodes have been described. Surface electrochemical parameters of the modified electrodes showed that these MPc-SAMs are densely packed with flat orientations. The electrochemical, electrocatalytic and stability properties of these MPc complexes follow this order: FePc > MnPc > CoPc. This finding is remarkable as it suggests that the success of using this method of self-assembling of MPc onto gold electrode is largely dependent on the bond distance between the pyridine linker and the central metal of the MPc; the shorter the distance, the faster the co-ordination and the better the electrocatalytic properties towards L-cysteine and thiocyanate. Thus, the superiority of FePc-based SAM over those of the MnPc and CoPc, has been proposed to be the result of the more favorable axial co-ordination properties of FePc with pyridine (i.e. shorter Fe–N(pyridine) bond length.
- Full Text:
- Date Issued: 2006
Comprehension and acceptability of a patient information leaflet (PIL) for antiretroviral therapy:
- Mwingira, Betty, Dowse, Roslind
- Authors: Mwingira, Betty , Dowse, Roslind
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156902 , vital:40065 , https://doi.org/10.4102/hsag.v11i3.236
- Description: The patient information leaflet (PIL) is recognised as playing a key role in informing patients about their medicines. The objectives of this research were to evaluate the readability and understanding of a PIL for the first-line ARV (antiretroviral) regimen available in the South African public health sector, and investigate its acceptability in the target Xhosa population. The study took place between August 2003 and July 2004. A PIL was designed for the antiretroviral regimen of stavudine, lamivudine and efavirenz, using established usability guidelines. South African legal requirements concerning PILs were incorporated and the PILs were available in both English and isiXhosa.
- Full Text:
- Date Issued: 2006
- Authors: Mwingira, Betty , Dowse, Roslind
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/156902 , vital:40065 , https://doi.org/10.4102/hsag.v11i3.236
- Description: The patient information leaflet (PIL) is recognised as playing a key role in informing patients about their medicines. The objectives of this research were to evaluate the readability and understanding of a PIL for the first-line ARV (antiretroviral) regimen available in the South African public health sector, and investigate its acceptability in the target Xhosa population. The study took place between August 2003 and July 2004. A PIL was designed for the antiretroviral regimen of stavudine, lamivudine and efavirenz, using established usability guidelines. South African legal requirements concerning PILs were incorporated and the PILs were available in both English and isiXhosa.
- Full Text:
- Date Issued: 2006
Confession and public life in post‐apartheid South Africa: A Foucauldian reading of Antjie Krog's country of my skull
- Authors: Garman, Anthea
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/159724 , vital:40337 , DOI: 10.1080/02564710608530406
- Description: Truth commissions around the world have given the technique of confession a new public currency and political power. Many works of literature thematising these commissions have also adopted the technique of confession for literary purposes. In this paper I bring Foucault's understanding of the technique of confession, and his discourse on the role of public intellectuals in modernity, to bear upon an examination of Antjie Krog's literary reflection of the work of the Truth and Reconciliation Commission (TRC), entitled Country of My Skull (1998). I look at how this text, and Krog's subsequent public intellectual status as a witness of the TRC, perpetuate the technique of confession without problematising it in ways that Foucault's work would suggest is necessary.
- Full Text:
- Date Issued: 2006
- Authors: Garman, Anthea
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/159724 , vital:40337 , DOI: 10.1080/02564710608530406
- Description: Truth commissions around the world have given the technique of confession a new public currency and political power. Many works of literature thematising these commissions have also adopted the technique of confession for literary purposes. In this paper I bring Foucault's understanding of the technique of confession, and his discourse on the role of public intellectuals in modernity, to bear upon an examination of Antjie Krog's literary reflection of the work of the Truth and Reconciliation Commission (TRC), entitled Country of My Skull (1998). I look at how this text, and Krog's subsequent public intellectual status as a witness of the TRC, perpetuate the technique of confession without problematising it in ways that Foucault's work would suggest is necessary.
- Full Text:
- Date Issued: 2006
Cultural significance of biodiversity: the role of medicinal plants in urban African cultural practices in the Eastern Cape, South Africa
- Cocks, Michelle L, Dold, Anthony P
- Authors: Cocks, Michelle L , Dold, Anthony P
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141338 , vital:37963 , DOI: 10.2993/0278-0771(2006)26[60:CSOBTR]2.0.CO;2
- Description: Since the International Convention on Biodiversity in 1992 conservation biologists, ecologists and conservationists have devoted considerable attention to the conservation of biodiversity. With this has come the realization that solutions to biological problems often lie in the mechanisms of social, cultural, and economic systems. This shift has emphasized the relationship between biodiversity and human diversity, or what the Declaration of Belem (1988) calls an “inextricable link” between biological and cultural diversity. The term biocultural diversity was introduced by Posey to describe the concept denoting this link. To date this concept has been used only in reference to “indigenous people” who, as part of their traditional lifestyles, use biodiversity to sustain their cultural identity. Our research, however, demonstrates that Xhosa people (amaXhosa) living in an urban context in the Eastern Cape Province of South Africa continue to use wild plants for cultural purposes and often access these through commercial trade. We suggest that recognition of the cultural and spiritual values associated with wild plants would greatly enhance biodiversity conservation efforts. Recognition of the significant role that wild plants play in fulfilling cultural needs for urban Xhosa people would go a long way towards achieving this.
- Full Text:
- Date Issued: 2006
- Authors: Cocks, Michelle L , Dold, Anthony P
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141338 , vital:37963 , DOI: 10.2993/0278-0771(2006)26[60:CSOBTR]2.0.CO;2
- Description: Since the International Convention on Biodiversity in 1992 conservation biologists, ecologists and conservationists have devoted considerable attention to the conservation of biodiversity. With this has come the realization that solutions to biological problems often lie in the mechanisms of social, cultural, and economic systems. This shift has emphasized the relationship between biodiversity and human diversity, or what the Declaration of Belem (1988) calls an “inextricable link” between biological and cultural diversity. The term biocultural diversity was introduced by Posey to describe the concept denoting this link. To date this concept has been used only in reference to “indigenous people” who, as part of their traditional lifestyles, use biodiversity to sustain their cultural identity. Our research, however, demonstrates that Xhosa people (amaXhosa) living in an urban context in the Eastern Cape Province of South Africa continue to use wild plants for cultural purposes and often access these through commercial trade. We suggest that recognition of the cultural and spiritual values associated with wild plants would greatly enhance biodiversity conservation efforts. Recognition of the significant role that wild plants play in fulfilling cultural needs for urban Xhosa people would go a long way towards achieving this.
- Full Text:
- Date Issued: 2006
Destined to come to blows?: race and constructions of “rational-intellectual” masculinity ten years after apartheid
- Authors: Vincent, Louise
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141619 , vital:37990 , DOI: 10.1177/1097184X05277694
- Description: In 1994, a democratic government came to power in South Africa for the first time in the country's history. But political transition is never a single event or moment. Rather, it is a continuous process that faces setbacks and contradictions. One of the questions we might ask about a society in transition is to what extent its gender order has changed or is changing. The present paper sets out to read the country's transformation drama through the lens of contested conceptions of South African masculinity. The article is focused on one particular version of masculinity which it terms “rational-intellectual man,” and the argument is that a legacy of racism and the persistence of racialized modes of reasoning continue to marginalise black men from this and other powerful, high-status forms of hegemonic masculinity.
- Full Text:
- Date Issued: 2006
- Authors: Vincent, Louise
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141619 , vital:37990 , DOI: 10.1177/1097184X05277694
- Description: In 1994, a democratic government came to power in South Africa for the first time in the country's history. But political transition is never a single event or moment. Rather, it is a continuous process that faces setbacks and contradictions. One of the questions we might ask about a society in transition is to what extent its gender order has changed or is changing. The present paper sets out to read the country's transformation drama through the lens of contested conceptions of South African masculinity. The article is focused on one particular version of masculinity which it terms “rational-intellectual man,” and the argument is that a legacy of racism and the persistence of racialized modes of reasoning continue to marginalise black men from this and other powerful, high-status forms of hegemonic masculinity.
- Full Text:
- Date Issued: 2006
Developing a test for economic duress in the South African law of contract: a comparative perspective
- Authors: Glover, Graham B
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/70832 , vital:29748 , https://hdl.handle.net/10520/EJC53694
- Description: Until the recent Supreme Court of Appeal decision in Medscheme Holdings (Pty) Ltd v Bhamjee 2005 (5) SA 339 (SCA), the courts in South Africa consistently adopted the attitude that so-called 'economic duress' does not constitute a valid cause of action in our law of contract. In this sense, our law lags behind other jurisdictions, which have recognised for some time that threats of economic harm can be just as coercive as threats to person or property, especially in the modern commercial word. While the indication given in the Medscheme case that our law could develop to recognise cases of economic duress is a welcome one, the court's statement in this regard was merely obiter, and the court consequently undertook no analysis of the issue. In this article, an attempt is made to develop guidelines for dealing with such cases, in accordance with a more modern and coherent test for duress in contract generally. Much of the discussion involves comparative analyses of the authorities on economic duress in Anglo-American jurisdictions, since there is a dearth of authority on the point in South Africa.
- Full Text: false
- Date Issued: 2006
- Authors: Glover, Graham B
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/70832 , vital:29748 , https://hdl.handle.net/10520/EJC53694
- Description: Until the recent Supreme Court of Appeal decision in Medscheme Holdings (Pty) Ltd v Bhamjee 2005 (5) SA 339 (SCA), the courts in South Africa consistently adopted the attitude that so-called 'economic duress' does not constitute a valid cause of action in our law of contract. In this sense, our law lags behind other jurisdictions, which have recognised for some time that threats of economic harm can be just as coercive as threats to person or property, especially in the modern commercial word. While the indication given in the Medscheme case that our law could develop to recognise cases of economic duress is a welcome one, the court's statement in this regard was merely obiter, and the court consequently undertook no analysis of the issue. In this article, an attempt is made to develop guidelines for dealing with such cases, in accordance with a more modern and coherent test for duress in contract generally. Much of the discussion involves comparative analyses of the authorities on economic duress in Anglo-American jurisdictions, since there is a dearth of authority on the point in South Africa.
- Full Text: false
- Date Issued: 2006
Editorial: tracing actors, actants and relational dynamics in environmental education research
- Authors: Lotz-Sisitka, Heila
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/67400 , vital:29084 , https://www.ajol.info/index.php/sajee/article/view/122719
- Description: publisher version , Introduction: This edition of the EEASA Journal provides insight into a range of relationships in the field of environmental education, and the complexities that exist around them, as reflected in the combination of papers. This Editorial picks up on the methodological ‘note’ (or is it a challenge?) provided by Godwell Nhamo in his paper in this edition of the journal. He provides a description of the possibilities that actor network theory provides for describing and explaining environmental policy processes, and recommends that environmental educators consider this methodology in their analyses. In particular, he refers environmental educators to applications of actor network theory for tracing relational dynamics between actors (i.e., environmental education practitioners) and actants which are non-human referents (e.g., the UN Decade of Education for Sustainable Development and UNESCO’s (2005) International Implementation Scheme). In response to his paper, I have chosen to ‘pick up’ on this methodological discussion in this Editorial, by considering aspects of this theoretical perspective in describing the ‘happenings’ that occur across the pages of this edition of the EEASA Journal. In doing so, I highlight (in part) the diversity of actors and actants that are influencing the field of environmental education, their subject matter and contexts, and I highlight the relational dynamics that become evident when one accepts a methodology that aims to trace such dynamics. In particular, this Editorial considers how ‘The language of actors, actants and actor/actant-networks brings to the fore the relationships and complexities that exist around them’ (Nhamo, this edition).
- Full Text:
- Date Issued: 2006
- Authors: Lotz-Sisitka, Heila
- Date: 2006
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/67400 , vital:29084 , https://www.ajol.info/index.php/sajee/article/view/122719
- Description: publisher version , Introduction: This edition of the EEASA Journal provides insight into a range of relationships in the field of environmental education, and the complexities that exist around them, as reflected in the combination of papers. This Editorial picks up on the methodological ‘note’ (or is it a challenge?) provided by Godwell Nhamo in his paper in this edition of the journal. He provides a description of the possibilities that actor network theory provides for describing and explaining environmental policy processes, and recommends that environmental educators consider this methodology in their analyses. In particular, he refers environmental educators to applications of actor network theory for tracing relational dynamics between actors (i.e., environmental education practitioners) and actants which are non-human referents (e.g., the UN Decade of Education for Sustainable Development and UNESCO’s (2005) International Implementation Scheme). In response to his paper, I have chosen to ‘pick up’ on this methodological discussion in this Editorial, by considering aspects of this theoretical perspective in describing the ‘happenings’ that occur across the pages of this edition of the EEASA Journal. In doing so, I highlight (in part) the diversity of actors and actants that are influencing the field of environmental education, their subject matter and contexts, and I highlight the relational dynamics that become evident when one accepts a methodology that aims to trace such dynamics. In particular, this Editorial considers how ‘The language of actors, actants and actor/actant-networks brings to the fore the relationships and complexities that exist around them’ (Nhamo, this edition).
- Full Text:
- Date Issued: 2006
Electrocatalytic oxidation of thiocyanate, L-cysteine and 2-mercaptoethanol by self-assembled monolayer of cobalt tetraethoxy thiophene phthalocyanine
- Sehlotho, Nthapo, Nyokong, Tebello
- Authors: Sehlotho, Nthapo , Nyokong, Tebello
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/283814 , vital:55993 , xlink:href="https://doi.org/10.1016/j.electacta.2005.12.024"
- Description: Catalytic activity of a self-assembled monolayer (SAM) of cobalt tetra ethoxythiophene phthalocyanine (CoTEThPc-SAM) complex towards oxidation of thiocyanate (SCN−), L-cysteine (CYS) and 2-mercaptoethanol (2-ME) is reported. The oxidation of thiocyanate occurs via a two electron transfer, whereas L-cysteine and 2-ME require 1 electron. The oxidation of thiocyanate is catalysed by ring based processes, while L-cysteine is catalysed by both CoIII/CoII process and by ring based processes. 2-ME is catalysed by CoIII/CoII process. The oxidation of thiocyanate on CoTEThPc was performed in acid media instead of basic media commonly employed. The reaction order was found to be unity for all the analytes, showing that only one molecule of analyte interacts with one molecule of the catalyst during the rate determining step.
- Full Text:
- Date Issued: 2006
- Authors: Sehlotho, Nthapo , Nyokong, Tebello
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/283814 , vital:55993 , xlink:href="https://doi.org/10.1016/j.electacta.2005.12.024"
- Description: Catalytic activity of a self-assembled monolayer (SAM) of cobalt tetra ethoxythiophene phthalocyanine (CoTEThPc-SAM) complex towards oxidation of thiocyanate (SCN−), L-cysteine (CYS) and 2-mercaptoethanol (2-ME) is reported. The oxidation of thiocyanate occurs via a two electron transfer, whereas L-cysteine and 2-ME require 1 electron. The oxidation of thiocyanate is catalysed by ring based processes, while L-cysteine is catalysed by both CoIII/CoII process and by ring based processes. 2-ME is catalysed by CoIII/CoII process. The oxidation of thiocyanate on CoTEThPc was performed in acid media instead of basic media commonly employed. The reaction order was found to be unity for all the analytes, showing that only one molecule of analyte interacts with one molecule of the catalyst during the rate determining step.
- Full Text:
- Date Issued: 2006
Electropolymerizable iron (III) and cobalt (II) dicyanophenoxy tetraphenylporphyrin complexes
- Ozoemena, Kenneth I, Zhao, Zhixin, Nyokong, Tebello
- Authors: Ozoemena, Kenneth I , Zhao, Zhixin , Nyokong, Tebello
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/286080 , vital:56236 , xlink:href="https://doi.org/10.1016/j.inoche.2005.11.024"
- Description: Solution and solid phase electrochemical features of 5-[4-(3,4-dicyanophenoxy)phenyl],10,15,20-triphenylporphyrin complexes of iron(III) (FeCNOTPP(Cl)) and cobalt(II) (CoCNOTPP) have been described. These novel asymmetric dicyanophenoxy-derivatised cobalt and iron porphyrin complexes were electropolymerised onto glassy carbon electrodes, which in aqueous solutions, gave surface concentrations (ca. 10−10 mol cm−2) typical of monolayer coverages. The films also exhibited excellent stability and electrocatalysis towards the direct detection of important analytes as nitrite, nitric oxide, and hydrogen peroxide in aqueous solutions.
- Full Text:
- Date Issued: 2006
- Authors: Ozoemena, Kenneth I , Zhao, Zhixin , Nyokong, Tebello
- Date: 2006
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/286080 , vital:56236 , xlink:href="https://doi.org/10.1016/j.inoche.2005.11.024"
- Description: Solution and solid phase electrochemical features of 5-[4-(3,4-dicyanophenoxy)phenyl],10,15,20-triphenylporphyrin complexes of iron(III) (FeCNOTPP(Cl)) and cobalt(II) (CoCNOTPP) have been described. These novel asymmetric dicyanophenoxy-derivatised cobalt and iron porphyrin complexes were electropolymerised onto glassy carbon electrodes, which in aqueous solutions, gave surface concentrations (ca. 10−10 mol cm−2) typical of monolayer coverages. The films also exhibited excellent stability and electrocatalysis towards the direct detection of important analytes as nitrite, nitric oxide, and hydrogen peroxide in aqueous solutions.
- Full Text:
- Date Issued: 2006