An analysis of factors affecting media freedom at the South African Broadcasting Corporation
- Authors: Mawandu, Charity Lufuno
- Date: 2022-12
- Subjects: Mass media – Censorship – South Africa , Freedom of the press --South Africa – History
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59337 , vital:62065
- Description: This research sought to analyse factors that affect media freedom at the South African Broadcasting Corporation using a descriptive research design and qualitative research methodology. Studies and media reports show that the South African Broadcasting Corporation is facing a myriad of challenges including woes related to media freedom hampering its mandate to inform, educate and entertain the public of South Africa. There is a dearth of studies conducted to understand the media freedom challenges at the South African Broadcasting Corporation. A qualitative approach was used in data collection, and in-depth interviews were utilised as instruments to collect data from participants. Non-probability sampling in particular purposive sampling method was used to select 4 directors, 4 editors and 4 journalists at the South African Broadcasting Corporation. Data was analysed using thematic analysis. The findings show that challenges facing the South African Broadcasting Corporation include poor legal environment as the broadcaster lacks support from government to implement effective policies to protect employees and create a media freedom environment to allow workers to carry out their work independently. The study found that the political environment in the South African Broadcasting Corporation at affects media freedom. Some political 0rganisations, influential individuals and entities are meddling in the operation of the broadcaster by trying to influence the narrative of the content broadcasted. The finding revealed that economic environment at the broadcaster is affects media freedom. The broadcaster is struggling financially resulting in poor income for employees, retrenchments, and inability to run approved programmes. In the context of constitution and policies, there is need for the South African Broadcasting Corporation to develop strategies that will specifically address both internal and external political, economic, and legal challenges it is facing if it is to be a high performing, financially sustainable, digitised national public broadcaster that provides compelling, informative, educational, and entertaining content via all platforms. , Thesis (MA) -- Faculty of Humanities , School of language Media and Communications, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Mawandu, Charity Lufuno
- Date: 2022-12
- Subjects: Mass media – Censorship – South Africa , Freedom of the press --South Africa – History
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59337 , vital:62065
- Description: This research sought to analyse factors that affect media freedom at the South African Broadcasting Corporation using a descriptive research design and qualitative research methodology. Studies and media reports show that the South African Broadcasting Corporation is facing a myriad of challenges including woes related to media freedom hampering its mandate to inform, educate and entertain the public of South Africa. There is a dearth of studies conducted to understand the media freedom challenges at the South African Broadcasting Corporation. A qualitative approach was used in data collection, and in-depth interviews were utilised as instruments to collect data from participants. Non-probability sampling in particular purposive sampling method was used to select 4 directors, 4 editors and 4 journalists at the South African Broadcasting Corporation. Data was analysed using thematic analysis. The findings show that challenges facing the South African Broadcasting Corporation include poor legal environment as the broadcaster lacks support from government to implement effective policies to protect employees and create a media freedom environment to allow workers to carry out their work independently. The study found that the political environment in the South African Broadcasting Corporation at affects media freedom. Some political 0rganisations, influential individuals and entities are meddling in the operation of the broadcaster by trying to influence the narrative of the content broadcasted. The finding revealed that economic environment at the broadcaster is affects media freedom. The broadcaster is struggling financially resulting in poor income for employees, retrenchments, and inability to run approved programmes. In the context of constitution and policies, there is need for the South African Broadcasting Corporation to develop strategies that will specifically address both internal and external political, economic, and legal challenges it is facing if it is to be a high performing, financially sustainable, digitised national public broadcaster that provides compelling, informative, educational, and entertaining content via all platforms. , Thesis (MA) -- Faculty of Humanities , School of language Media and Communications, 2022
- Full Text:
- Date Issued: 2022-12
The development of a flow route to synthesize 3- benzyl-6-bromo-2-methoxyquinoline, an intermediate of an anti-TB drug, bedaquilin
- Authors: Mpalala, Anele
- Date: 2022-12
- Subjects: Multidrug-resistant tuberculosis -- South Africa , Tuberculosis --Chemotherapy -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59864 , vital:62455
- Description: SA has a high number of reported cases of multidrug-resistant tuberculosis (MDR-TB). Bedaquiline is a newly approved active ingredient of an anti-tuberculosis drug with high potency against MDR-TB. The limited access to this life-saving medicine to many people in the world has driven a great deal of research effort by the scientific community to find new, better and more practical approaches to this drug. However, many of the reported synthetic procedures suffer from long reaction times, which in turn require many hours of effort by the chemists conducting the reactions. This has prompted us to investigate an efficient process towards the synthesis to produce the key intermediates of bedaquiline using continuous flow technology. Additionally, since there is not much literature on continuous flow synthesis of bedaquiline, this research revealed interesting continuous flow processes towards the drug. Chapter 1: In order to provide insight, the first chapter of this dissertation presents a comprehensive background and literature review on tuberculosis; its pathogenesis, impact, medicines available for the treatment as well as the drug classes with novel mode of action and new chemical entities. Furthermore, bedaquiline is discussed in detail with the various synthetic protocols of the drug. An introduction to continuous flow chemistry is discussed, along with an outline of its advantages and disadvantages. Chapter 2: The second chapter encompasses the experimental procedures utilized for both batch and continuous flow syntheses. The three key intermediates of bedaquiline were synthesized in batch synthesis and these compounds were characterized using 1H-NMR, 13C-NMR and FT-IR spectroscopy. Subsequently, the continuous flow synthesis protocols for the preparations of these intermediates and their optimization are outlined. Chapter 3: The results are explained in this chapter with detailed discussions of the batch synthesis and the continuous flow optimization of each step within the scope of this research. The investigation started with the batch preparation of the primary intermediate, N-(4-bromophenyl)-3-phenylpropanamide via an amidation reaction between 3-phenylpropanoyl chloride and p-bromoaniline. The primary intermediate then undergoes a subsequent formylation and cyclization via a Vilsmeier–Haack reaction to yield 3-benzyl-6-bromo-2-chloroquinoline. The chloroquinoline ii intermediate undergoes a methoxylation reaction to form 3-benzyl-6-bromo-2- methoxyquinoline. Subsequently, the batch protocol was transferred into continuous flow systems, optimized by varying reaction parameters within the synthesis route to achieve the as much yield as possible. The optimization studies showed an improvement in conversions in the various steps with shorter reaction times. The first step was optimized in a 0.2ml microreactor and because of the enhanced safety of flow chemistry, this exothermic amidation reaction was optimised at elevated temperatures to afford the primary intermediate at a 100% conversion within a residence time of 5 seconds using DMF as a solvent with DIPEA as a base. Next, the Vilsmier-Haack cyclization and chlorination was optimised in flow to afford the 2-chloroquinoline intermediate. The ability to use a back pressure regulator allowed for investigation of the effect of high temperature on the reaction and the 2- chloroquinoline intermediate was obtained at 78% conversion in a residence time of 30 min at 150 ⁰C using acetonitrile as a solvent. Subsequently, the optimization of the third step in flow to afford the central core intermediate of bedaquiline, 3-benzyl-6-bromo-2-methoxyquinoline, achieved 100% conversion in DMSO/MeOH solvent system at a residence time of 5 min. The effect of temperature, molar equivalence and solvent on reaction conversions could be observed in these steps. The results obtained from this study clearly demonstrated the successful establishment of an efficient flow chemistry protocol that can be used to successfully synthesize all intermediates within the scope of this research. , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Mpalala, Anele
- Date: 2022-12
- Subjects: Multidrug-resistant tuberculosis -- South Africa , Tuberculosis --Chemotherapy -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/59864 , vital:62455
- Description: SA has a high number of reported cases of multidrug-resistant tuberculosis (MDR-TB). Bedaquiline is a newly approved active ingredient of an anti-tuberculosis drug with high potency against MDR-TB. The limited access to this life-saving medicine to many people in the world has driven a great deal of research effort by the scientific community to find new, better and more practical approaches to this drug. However, many of the reported synthetic procedures suffer from long reaction times, which in turn require many hours of effort by the chemists conducting the reactions. This has prompted us to investigate an efficient process towards the synthesis to produce the key intermediates of bedaquiline using continuous flow technology. Additionally, since there is not much literature on continuous flow synthesis of bedaquiline, this research revealed interesting continuous flow processes towards the drug. Chapter 1: In order to provide insight, the first chapter of this dissertation presents a comprehensive background and literature review on tuberculosis; its pathogenesis, impact, medicines available for the treatment as well as the drug classes with novel mode of action and new chemical entities. Furthermore, bedaquiline is discussed in detail with the various synthetic protocols of the drug. An introduction to continuous flow chemistry is discussed, along with an outline of its advantages and disadvantages. Chapter 2: The second chapter encompasses the experimental procedures utilized for both batch and continuous flow syntheses. The three key intermediates of bedaquiline were synthesized in batch synthesis and these compounds were characterized using 1H-NMR, 13C-NMR and FT-IR spectroscopy. Subsequently, the continuous flow synthesis protocols for the preparations of these intermediates and their optimization are outlined. Chapter 3: The results are explained in this chapter with detailed discussions of the batch synthesis and the continuous flow optimization of each step within the scope of this research. The investigation started with the batch preparation of the primary intermediate, N-(4-bromophenyl)-3-phenylpropanamide via an amidation reaction between 3-phenylpropanoyl chloride and p-bromoaniline. The primary intermediate then undergoes a subsequent formylation and cyclization via a Vilsmeier–Haack reaction to yield 3-benzyl-6-bromo-2-chloroquinoline. The chloroquinoline ii intermediate undergoes a methoxylation reaction to form 3-benzyl-6-bromo-2- methoxyquinoline. Subsequently, the batch protocol was transferred into continuous flow systems, optimized by varying reaction parameters within the synthesis route to achieve the as much yield as possible. The optimization studies showed an improvement in conversions in the various steps with shorter reaction times. The first step was optimized in a 0.2ml microreactor and because of the enhanced safety of flow chemistry, this exothermic amidation reaction was optimised at elevated temperatures to afford the primary intermediate at a 100% conversion within a residence time of 5 seconds using DMF as a solvent with DIPEA as a base. Next, the Vilsmier-Haack cyclization and chlorination was optimised in flow to afford the 2-chloroquinoline intermediate. The ability to use a back pressure regulator allowed for investigation of the effect of high temperature on the reaction and the 2- chloroquinoline intermediate was obtained at 78% conversion in a residence time of 30 min at 150 ⁰C using acetonitrile as a solvent. Subsequently, the optimization of the third step in flow to afford the central core intermediate of bedaquiline, 3-benzyl-6-bromo-2-methoxyquinoline, achieved 100% conversion in DMSO/MeOH solvent system at a residence time of 5 min. The effect of temperature, molar equivalence and solvent on reaction conversions could be observed in these steps. The results obtained from this study clearly demonstrated the successful establishment of an efficient flow chemistry protocol that can be used to successfully synthesize all intermediates within the scope of this research. , Thesis (MSc) -- Faculty of Science, School of Biomolecular and Chemical Sciences, 2022
- Full Text:
- Date Issued: 2022-12
Main thesis title: subtitle if needed. If no subtitle follow instructions in manual
- Authors: Surname, name
- Date: 2022-04
- Subjects: Port Elizabeth (South Africa) , Eastern Cape (South Africa) , South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/57885 , vital:58305
- Description: Abstract. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2022
- Full Text: false
- Date Issued: 2022-04
- Authors: Surname, name
- Date: 2022-04
- Subjects: Port Elizabeth (South Africa) , Eastern Cape (South Africa) , South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/57885 , vital:58305
- Description: Abstract. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2022
- Full Text: false
- Date Issued: 2022-04
Main thesis title: subtitle if needed. If no subtitle follow instructions in manual
- Authors: Surname, name
- Date: 2022-04
- Subjects: Port Elizabeth (South Africa) , Eastern Cape (South Africa) , South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/58827 , vital:60168
- Description: Abstract. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2022
- Full Text:
- Date Issued: 2022-04
- Authors: Surname, name
- Date: 2022-04
- Subjects: Port Elizabeth (South Africa) , Eastern Cape (South Africa) , South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/58827 , vital:60168
- Description: Abstract. , Thesis (MSc) -- Faculty of Science, School of Environmental Sciences, 2022
- Full Text:
- Date Issued: 2022-04
State Antiquity and Early Agricultural transition as Deep economic roots in Africa
- Authors: Fani, Sisipho
- Date: 2022-04
- Subjects: Agriculture -- Economic aspects , Agriculture -- Early works to 1800
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/57643 , vital:58189
- Description: Growth economists identified that current failures and successes of economies can be traced far in their histories. The Unified Growth Model has been developed to analyse the process of development. Economic researchers have developed and identified ‘deep roots’ variables that elaborate modern growth, institutions and development. These variables include State Antiquity and Early agricultural transition. The study is an examination of the effects of State Antiquity and Early agricultural transition in the 54 African economies. The study examines these effects employing the following years: 1990, 1995, 2000, 2005, 2010, 2015, and 2020. The study employs econometric models namely, Ordinary Least Squares, Ridge and Lasso regularization models to examine the effects of these deep root variables. The study borrows baseline regressions from the works of Bockstette, Chanda and Putterman (2002), Putterman and Weil (2010) and Borcan, Olsson and Putterman (2018). This study, to the best of our knowledge, is the first to empirically examine the effects of State Antiquity and Early agricultural transition in Africa. The results of the study suggest that African economies that have low level of state antiquity experience a positive effect on modern economic growth and development whilst African economies with high levels of state antiquity experience negative effect on modern economic growth and development. The results also suggest that African economies that transition at a later stage toward agriculture experience a positive effect on modern economic growth and development. The implications of these findings indicate that state antiquity and early agricultural transition influence modern economic development only when states have reached a certain level. Countries that transitioned early towards agriculture experience a negative effect on modern economic growth and development depicting a reversal of fortune. The study recommends that the implementation of polices should corelate with the state experience of the specific economy. , Thesis (MA) -- Faculty of Business and Economic science , 2022
- Full Text:
- Date Issued: 2022-04
- Authors: Fani, Sisipho
- Date: 2022-04
- Subjects: Agriculture -- Economic aspects , Agriculture -- Early works to 1800
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/57643 , vital:58189
- Description: Growth economists identified that current failures and successes of economies can be traced far in their histories. The Unified Growth Model has been developed to analyse the process of development. Economic researchers have developed and identified ‘deep roots’ variables that elaborate modern growth, institutions and development. These variables include State Antiquity and Early agricultural transition. The study is an examination of the effects of State Antiquity and Early agricultural transition in the 54 African economies. The study examines these effects employing the following years: 1990, 1995, 2000, 2005, 2010, 2015, and 2020. The study employs econometric models namely, Ordinary Least Squares, Ridge and Lasso regularization models to examine the effects of these deep root variables. The study borrows baseline regressions from the works of Bockstette, Chanda and Putterman (2002), Putterman and Weil (2010) and Borcan, Olsson and Putterman (2018). This study, to the best of our knowledge, is the first to empirically examine the effects of State Antiquity and Early agricultural transition in Africa. The results of the study suggest that African economies that have low level of state antiquity experience a positive effect on modern economic growth and development whilst African economies with high levels of state antiquity experience negative effect on modern economic growth and development. The results also suggest that African economies that transition at a later stage toward agriculture experience a positive effect on modern economic growth and development. The implications of these findings indicate that state antiquity and early agricultural transition influence modern economic development only when states have reached a certain level. Countries that transitioned early towards agriculture experience a negative effect on modern economic growth and development depicting a reversal of fortune. The study recommends that the implementation of polices should corelate with the state experience of the specific economy. , Thesis (MA) -- Faculty of Business and Economic science , 2022
- Full Text:
- Date Issued: 2022-04
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