Exploring risk related to future climates through role-playing games: the African catchment game
- Rowntree, Kate M, Fraenkel, Linda A, Fox, Roddy C
- Authors: Rowntree, Kate M , Fraenkel, Linda A , Fox, Roddy C
- Date: 2009
- Language: English
- Type: Conference paper
- Identifier: vital:6671 , http://hdl.handle.net/10962/d1006807
- Description: Risk is the result of two interacting components: hazard and vulnerability. Climatic hazards are related to extrinsic factors such as drought or severe storms. Vul- nerability is the result of intrinsic factors that often arise from the socio-political- economic context. The interplay of risk and vulnerability is difficult to predict. Although computer models have been widely used to forecast climate related risk, albeit with con- siderable uncertainty, they can never capture sufficiently the vulnerability of human sys- tems to these hazards. Role-playing games can be used more realistically to simulate pos- sible outcomes of different climate change scenarios, and allow players to reflect on their significance. The authors have developed the African Catchment Game to simulate a wa- ter scarce African country. Risk can be modelled mechanistically by changing the nature of the annual rainfall input. Vulnerability can in part be modelled by changing the start- ing parameters (such as access to land and resources) and, secondly, through the unpredictable response of players to game dynamics. Players’ reflections demonstrate that through the game they become more aware of the concept of risk and the complex response of individuals and societies that determine their vulnerability to climatic hazards. This paper reflects on the potential for developing the game further as a tool for participatory learning around climate change, based on the authors’ experience of playing the game with participants from South Africa.
- Full Text:
- Date Issued: 2009
- Authors: Rowntree, Kate M , Fraenkel, Linda A , Fox, Roddy C
- Date: 2009
- Language: English
- Type: Conference paper
- Identifier: vital:6671 , http://hdl.handle.net/10962/d1006807
- Description: Risk is the result of two interacting components: hazard and vulnerability. Climatic hazards are related to extrinsic factors such as drought or severe storms. Vul- nerability is the result of intrinsic factors that often arise from the socio-political- economic context. The interplay of risk and vulnerability is difficult to predict. Although computer models have been widely used to forecast climate related risk, albeit with con- siderable uncertainty, they can never capture sufficiently the vulnerability of human sys- tems to these hazards. Role-playing games can be used more realistically to simulate pos- sible outcomes of different climate change scenarios, and allow players to reflect on their significance. The authors have developed the African Catchment Game to simulate a wa- ter scarce African country. Risk can be modelled mechanistically by changing the nature of the annual rainfall input. Vulnerability can in part be modelled by changing the start- ing parameters (such as access to land and resources) and, secondly, through the unpredictable response of players to game dynamics. Players’ reflections demonstrate that through the game they become more aware of the concept of risk and the complex response of individuals and societies that determine their vulnerability to climatic hazards. This paper reflects on the potential for developing the game further as a tool for participatory learning around climate change, based on the authors’ experience of playing the game with participants from South Africa.
- Full Text:
- Date Issued: 2009
The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1
- Parfitt, David A, Michael, Gregory J, Vermeulen, Esmeralda G M, Prodromou, Natalia V, Webb, Tom R, Gallo, Jean-Marc, Cheetham, Michael E, Nicoll, William S, Blatch, Gregory L, Chapple, J Paul
- Authors: Parfitt, David A , Michael, Gregory J , Vermeulen, Esmeralda G M , Prodromou, Natalia V , Webb, Tom R , Gallo, Jean-Marc , Cheetham, Michael E , Nicoll, William S , Blatch, Gregory L , Chapple, J Paul
- Date: 2009
- Language: English
- Type: Article
- Identifier: vital:6485 , http://hdl.handle.net/10962/d1006262 , http://hmg.oxfordjournals.org/content/18/9/1556
- Description: An extensive protein–protein interaction network has been identified between proteins implicated in inherited ataxias. The protein sacsin, which is mutated in the early-onset neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix-Saguenay, is a node in this interactome. Here, we have established the neuronal expression of sacsin and functionally characterized domains of the 4579 amino acid protein. Sacsin is most highly expressed in large neurons, particularly within brain motor systems, including cerebellar Purkinje cells. Its subcellular localization in SH-SY5Y neuroblastoma cells was predominantly cytoplasmic with a mitochondrial component. We identified a putative ubiquitin-like (UbL) domain at the N-terminus of sacsin and demonstrated an interaction with the proteasome. Furthermore, sacsin contains a predicted J-domain, the defining feature of DnaJ/Hsp40 proteins. Using a bacterial complementation assay, the sacsin J-domain was demonstrated to be functional. The presence of both UbL and J-domains in sacsin suggests that it may integrate the ubiquitin–proteasome system and Hsp70 function to a specific cellular role. The Hsp70 chaperone machinery is an important component of the cellular response towards aggregation prone mutant proteins that are associated with neurodegenerative diseases. We therefore investigated the effects of siRNA-mediated sacsin knockdown on polyglutamine-expanded ataxin-1. Importantly, SACS siRNA did not affect cell viability with GFP-ataxin-1[30Q], but enhanced the toxicity of GFP-ataxin- 1[82Q], suggesting that sacsin is protective against mutant ataxin-1. Thus, sacsin is an ataxia protein and a regulator of the Hsp70 chaperone machinery that is implicated in the processing of other ataxialinked proteins.
- Full Text:
- Date Issued: 2009
- Authors: Parfitt, David A , Michael, Gregory J , Vermeulen, Esmeralda G M , Prodromou, Natalia V , Webb, Tom R , Gallo, Jean-Marc , Cheetham, Michael E , Nicoll, William S , Blatch, Gregory L , Chapple, J Paul
- Date: 2009
- Language: English
- Type: Article
- Identifier: vital:6485 , http://hdl.handle.net/10962/d1006262 , http://hmg.oxfordjournals.org/content/18/9/1556
- Description: An extensive protein–protein interaction network has been identified between proteins implicated in inherited ataxias. The protein sacsin, which is mutated in the early-onset neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix-Saguenay, is a node in this interactome. Here, we have established the neuronal expression of sacsin and functionally characterized domains of the 4579 amino acid protein. Sacsin is most highly expressed in large neurons, particularly within brain motor systems, including cerebellar Purkinje cells. Its subcellular localization in SH-SY5Y neuroblastoma cells was predominantly cytoplasmic with a mitochondrial component. We identified a putative ubiquitin-like (UbL) domain at the N-terminus of sacsin and demonstrated an interaction with the proteasome. Furthermore, sacsin contains a predicted J-domain, the defining feature of DnaJ/Hsp40 proteins. Using a bacterial complementation assay, the sacsin J-domain was demonstrated to be functional. The presence of both UbL and J-domains in sacsin suggests that it may integrate the ubiquitin–proteasome system and Hsp70 function to a specific cellular role. The Hsp70 chaperone machinery is an important component of the cellular response towards aggregation prone mutant proteins that are associated with neurodegenerative diseases. We therefore investigated the effects of siRNA-mediated sacsin knockdown on polyglutamine-expanded ataxin-1. Importantly, SACS siRNA did not affect cell viability with GFP-ataxin-1[30Q], but enhanced the toxicity of GFP-ataxin- 1[82Q], suggesting that sacsin is protective against mutant ataxin-1. Thus, sacsin is an ataxia protein and a regulator of the Hsp70 chaperone machinery that is implicated in the processing of other ataxialinked proteins.
- Full Text:
- Date Issued: 2009
Of fences and peace between neighbours
- Authors: Krüger, Rósaan
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68909 , vital:29338 , https://hdl.handle.net/10520/EJC85309
- Description: Publisher version , The speaker in the poem "Mending Wall" by American poet Robert Frost questions the wisdom of the saying that "Good Fences Make Good Neighbo[u]rs" (1914 North of Boston lines 27 and 45). The walls or fences referred to in the poem represent more than just physical barriers separating adjacent premises; the speaker sees them as representing obstacles to communication and friendship between individuals. Seen from the perspective of the speaker, a fence or wall is a "bad" thing. But the speaker is but one of the parties to the neighbourly relationship. For the speaker's neighbour, a wall or a fence is "a protector of privacy" (Watson "Frost's Wall : The View from the Other Side" 1971 44 The New England Quarterly 653 655). Thus there are two views on walls or fences: they can be seen negatively as obstructing good relations, or positively as dividers that secure good relations between neighbours by separating them and protecting their privacy rights.
- Full Text: false
- Date Issued: 2009
- Authors: Krüger, Rósaan
- Date: 2009
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68909 , vital:29338 , https://hdl.handle.net/10520/EJC85309
- Description: Publisher version , The speaker in the poem "Mending Wall" by American poet Robert Frost questions the wisdom of the saying that "Good Fences Make Good Neighbo[u]rs" (1914 North of Boston lines 27 and 45). The walls or fences referred to in the poem represent more than just physical barriers separating adjacent premises; the speaker sees them as representing obstacles to communication and friendship between individuals. Seen from the perspective of the speaker, a fence or wall is a "bad" thing. But the speaker is but one of the parties to the neighbourly relationship. For the speaker's neighbour, a wall or a fence is "a protector of privacy" (Watson "Frost's Wall : The View from the Other Side" 1971 44 The New England Quarterly 653 655). Thus there are two views on walls or fences: they can be seen negatively as obstructing good relations, or positively as dividers that secure good relations between neighbours by separating them and protecting their privacy rights.
- Full Text: false
- Date Issued: 2009
Treating posttraumatic stress disorder in South Africa : an integrative model grounded in case-based research
- Authors: Edwards, David J A
- Date: 2009
- Language: English
- Type: Article
- Identifier: vital:6232 , http://hdl.handle.net/10962/d1007782
- Description: The article presents a model for formulating and planning treatment for post-traumatic stress disorder (PTSD) in South Africa derived from the existing literature and in conjunction with a review of a series of studies of cases treated using the guidelines of Ehlers and Clark's cognitive therapy. It is argued that the construction of psychotherapies (or even components of psychotherapy) for PTSD in terms of traditional categories ("psychodynamic", "cognitive-behavioural", "narrative" etc.) is misleading and unhelpful. Instead, superordinate concepts derived from thinking about evidence-based practice provide a more grounded focus on the practical issues faced by therapists treating PTSD. These concepts, which include competences and metcacompetences, therapist responsiveness, stages of therapy and case formulation, provide a basis for a genuinely integrative approach. The proposed model suggests seven broad areas of clinical focus for work with PTSD which can be arranged at three levels of priority: level 1 crisis intervention and stabilization; level 2 promoting engagement with treatment, and level 3 selection, sequencing and timing of active treatment interventions. Material from the case series is used to illustrate the application of the model.
- Full Text:
- Date Issued: 2009
- Authors: Edwards, David J A
- Date: 2009
- Language: English
- Type: Article
- Identifier: vital:6232 , http://hdl.handle.net/10962/d1007782
- Description: The article presents a model for formulating and planning treatment for post-traumatic stress disorder (PTSD) in South Africa derived from the existing literature and in conjunction with a review of a series of studies of cases treated using the guidelines of Ehlers and Clark's cognitive therapy. It is argued that the construction of psychotherapies (or even components of psychotherapy) for PTSD in terms of traditional categories ("psychodynamic", "cognitive-behavioural", "narrative" etc.) is misleading and unhelpful. Instead, superordinate concepts derived from thinking about evidence-based practice provide a more grounded focus on the practical issues faced by therapists treating PTSD. These concepts, which include competences and metcacompetences, therapist responsiveness, stages of therapy and case formulation, provide a basis for a genuinely integrative approach. The proposed model suggests seven broad areas of clinical focus for work with PTSD which can be arranged at three levels of priority: level 1 crisis intervention and stabilization; level 2 promoting engagement with treatment, and level 3 selection, sequencing and timing of active treatment interventions. Material from the case series is used to illustrate the application of the model.
- Full Text:
- Date Issued: 2009
Integrating environmental flow requirements into a stakeholder driven catchment management process
- Rowntree, Kate M, Birkholz, Sharon A, Burt, Jane C, Fox, Helen E
- Authors: Rowntree, Kate M , Birkholz, Sharon A , Burt, Jane C , Fox, Helen E
- Date: 2009
- Language: English
- Type: Conference paper
- Identifier: vital:6670 , http://hdl.handle.net/10962/d1006804
- Description: South Africa's National Water Act (NWA no 36 of 1998) recognizes the need for environmental protection through the ecological Reserve, defined in the Act as the quantity and quality of water required to protect aquatic ecosystems in order to secure ecologically sustainable development through the constrained use of the relevant water resource. Further more the NWA stipulates that the allocation of licenses to new water users, or the granting of increased water use to established water users, can only take place once the the Reserve for the river has been determined and approved by the Minister. This means that water users' needs (beyond those required for basic human needs) take second place behind the environment. Whether or not the inclusion of the ecological Reserve in South Africa's water legislation leads to sustainable use of South Africa's water resources depends on its successful implementation. This in turn depends on the will of both the Department of Water Affairs and Forestry (DWAF), the implementing agent, and the end water users who need to be convinced of the priority given to environmental needs. In this paper we look at the process of implementing the ecological Reserve in the Kat Valley in the Eastern Cape of South Africa as part of a stakeholder driven process of developing a water allocation plan for the catchment that prioritized participation by water users. The extent to which DWAF and the water users expedited or thwarted the process is examined in the light of national and international calls for local-level participation in water resource management processes.
- Full Text:
- Date Issued: 2009
- Authors: Rowntree, Kate M , Birkholz, Sharon A , Burt, Jane C , Fox, Helen E
- Date: 2009
- Language: English
- Type: Conference paper
- Identifier: vital:6670 , http://hdl.handle.net/10962/d1006804
- Description: South Africa's National Water Act (NWA no 36 of 1998) recognizes the need for environmental protection through the ecological Reserve, defined in the Act as the quantity and quality of water required to protect aquatic ecosystems in order to secure ecologically sustainable development through the constrained use of the relevant water resource. Further more the NWA stipulates that the allocation of licenses to new water users, or the granting of increased water use to established water users, can only take place once the the Reserve for the river has been determined and approved by the Minister. This means that water users' needs (beyond those required for basic human needs) take second place behind the environment. Whether or not the inclusion of the ecological Reserve in South Africa's water legislation leads to sustainable use of South Africa's water resources depends on its successful implementation. This in turn depends on the will of both the Department of Water Affairs and Forestry (DWAF), the implementing agent, and the end water users who need to be convinced of the priority given to environmental needs. In this paper we look at the process of implementing the ecological Reserve in the Kat Valley in the Eastern Cape of South Africa as part of a stakeholder driven process of developing a water allocation plan for the catchment that prioritized participation by water users. The extent to which DWAF and the water users expedited or thwarted the process is examined in the light of national and international calls for local-level participation in water resource management processes.
- Full Text:
- Date Issued: 2009
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