When an Editor Decides to Listen to a City: Heather Robertson, The Herald, and Nelson Mandela Bay
- Garman, Anthea, Malila, Vanessa
- Authors: Garman, Anthea , Malila, Vanessa
- Date: 2018
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/158427 , vital:40185 , ISBN 9781351664363
- Description: This book provides case studies, many incorporating in-depth interviews and surveys of journalists. It examines issues such as journalists’ attitudes toward their contributions to society; the impact of industry and technological changes; culture and minority issues in the newsroom and profession; the impact of censorship and self-censorship; and coping with psychological pressures and physical safety dilemmas. Its chapters also highlight journalists’ challenges in national and multinational contexts. International scholars, conducting research within a wide range of authoritarian, semi-democratic, and democratic systems, contributed to this examination of journalistic practices in the Arab World, Australia, Bangladesh, Bulgaria, China, Denmark, India, Kenya, Kyrgyzstan, Malaysia, Mexico, Russia, Samoa, South Africa, Taiwan, Turkey, and the United States.
- Full Text:
- Date Issued: 2018
- Authors: Garman, Anthea , Malila, Vanessa
- Date: 2018
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/158427 , vital:40185 , ISBN 9781351664363
- Description: This book provides case studies, many incorporating in-depth interviews and surveys of journalists. It examines issues such as journalists’ attitudes toward their contributions to society; the impact of industry and technological changes; culture and minority issues in the newsroom and profession; the impact of censorship and self-censorship; and coping with psychological pressures and physical safety dilemmas. Its chapters also highlight journalists’ challenges in national and multinational contexts. International scholars, conducting research within a wide range of authoritarian, semi-democratic, and democratic systems, contributed to this examination of journalistic practices in the Arab World, Australia, Bangladesh, Bulgaria, China, Denmark, India, Kenya, Kyrgyzstan, Malaysia, Mexico, Russia, Samoa, South Africa, Taiwan, Turkey, and the United States.
- Full Text:
- Date Issued: 2018
Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers:
- Lunga, Mayibongwe J, Chisango, Ruramai L, Weyers, Carli, Isaacs, Michelle, Taylor, Dale, Edkins, Adrienne L, Khanye, Setshaba D, Hoppe, Heinrich C, Veale, Clinton G L
- Authors: Lunga, Mayibongwe J , Chisango, Ruramai L , Weyers, Carli , Isaacs, Michelle , Taylor, Dale , Edkins, Adrienne L , Khanye, Setshaba D , Hoppe, Heinrich C , Veale, Clinton G L
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/164389 , vital:41114 , DOI: 10.1002/cmdc.201800235
- Description: Despite major strides in reducing Plasmodium falciparum infections, this parasite still accounts for roughly half a million annual deaths. This problem is compounded by the decreased efficacy of artemisinin combination therapies. Therefore, the development and optimisation of novel antimalarial chemotypes is critical. In this study, we describe our strategic approach to optimise a class of previously reported antimalarials, resulting in the discovery of 1-(5-chloro-1H-indol-3-yl)-2-[(4-cyanophenyl)thio]ethanone (13) and 1-(5-chloro-1H-indol-3-yl)-2-[(4-nitrophenyl)thio]ethanone (14), whose activity was equipotent to that of chloroquine against the P. falciparum 3D7 strain.
- Full Text:
- Date Issued: 2018
- Authors: Lunga, Mayibongwe J , Chisango, Ruramai L , Weyers, Carli , Isaacs, Michelle , Taylor, Dale , Edkins, Adrienne L , Khanye, Setshaba D , Hoppe, Heinrich C , Veale, Clinton G L
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/164389 , vital:41114 , DOI: 10.1002/cmdc.201800235
- Description: Despite major strides in reducing Plasmodium falciparum infections, this parasite still accounts for roughly half a million annual deaths. This problem is compounded by the decreased efficacy of artemisinin combination therapies. Therefore, the development and optimisation of novel antimalarial chemotypes is critical. In this study, we describe our strategic approach to optimise a class of previously reported antimalarials, resulting in the discovery of 1-(5-chloro-1H-indol-3-yl)-2-[(4-cyanophenyl)thio]ethanone (13) and 1-(5-chloro-1H-indol-3-yl)-2-[(4-nitrophenyl)thio]ethanone (14), whose activity was equipotent to that of chloroquine against the P. falciparum 3D7 strain.
- Full Text:
- Date Issued: 2018
Novobiocin–ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition.
- Mbaba, Mziyanda, de la Mare, Jo-Anne, Sterrenberg, Jason N, Kajewole, Deborah, Maharaj, Shantal, Edkins, Adrienne L, Isaacs, Michelle, Hoppe, Heinrich C, Khanye, Setshaba D
- Authors: Mbaba, Mziyanda , de la Mare, Jo-Anne , Sterrenberg, Jason N , Kajewole, Deborah , Maharaj, Shantal , Edkins, Adrienne L , Isaacs, Michelle , Hoppe, Heinrich C , Khanye, Setshaba D
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/122858 , vital:35359 , https://doi.org/10.1007/s00775-018-1634-9
- Description: A series of tailored novobiocin–ferrocene conjugates was prepared in moderate yields and investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 breast cancer line and Plasmodium falciparum 3D7 strain, respectively. While the target compounds displayed moderate anticancer activity against the breast cancer cell line with IC50 values in the mid-micromolar range, compounds 10a–c displayed promising antiplasmodial activity as low as 0.889 µM. Furthermore, the most promising compounds were tested for inhibitory effects against a postulated target, heat shock protein 90 (Hsp90).
- Full Text:
- Authors: Mbaba, Mziyanda , de la Mare, Jo-Anne , Sterrenberg, Jason N , Kajewole, Deborah , Maharaj, Shantal , Edkins, Adrienne L , Isaacs, Michelle , Hoppe, Heinrich C , Khanye, Setshaba D
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/122858 , vital:35359 , https://doi.org/10.1007/s00775-018-1634-9
- Description: A series of tailored novobiocin–ferrocene conjugates was prepared in moderate yields and investigated for in vitro anticancer and antiplasmodial activity against the MDA-MB-231 breast cancer line and Plasmodium falciparum 3D7 strain, respectively. While the target compounds displayed moderate anticancer activity against the breast cancer cell line with IC50 values in the mid-micromolar range, compounds 10a–c displayed promising antiplasmodial activity as low as 0.889 µM. Furthermore, the most promising compounds were tested for inhibitory effects against a postulated target, heat shock protein 90 (Hsp90).
- Full Text:
Rethinking the dialectics of rural and urban in African art and scholarship:
- Siegenthaler, Fiona, Nzewi, Ugochukwu-Smooth C, Siegert, Nadine
- Authors: Siegenthaler, Fiona , Nzewi, Ugochukwu-Smooth C , Siegert, Nadine
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146022 , vital:38488 , DOI: 10.1080/19301944.2018.1538856
- Description: This issue of Critical Interventions is dedicated to rethinking the dialectics of the rural and the urban in African art and scholarship. Inspired by the general theme of the European Conference of African Studies (ECAS/AEGIS) in Basel (June 28 to July 1, 2017), Urban Africa – Urban Africans: New Encounters of the Rural and the Urban, the guest editors of this issue hosted two panels on the relationship of urban-based artists and their interest in rural topographies, aesthetics, and cultural practices.
- Full Text:
- Date Issued: 2019
- Authors: Siegenthaler, Fiona , Nzewi, Ugochukwu-Smooth C , Siegert, Nadine
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146022 , vital:38488 , DOI: 10.1080/19301944.2018.1538856
- Description: This issue of Critical Interventions is dedicated to rethinking the dialectics of the rural and the urban in African art and scholarship. Inspired by the general theme of the European Conference of African Studies (ECAS/AEGIS) in Basel (June 28 to July 1, 2017), Urban Africa – Urban Africans: New Encounters of the Rural and the Urban, the guest editors of this issue hosted two panels on the relationship of urban-based artists and their interest in rural topographies, aesthetics, and cultural practices.
- Full Text:
- Date Issued: 2019
A missing link in the estuarine nitrogen cycle?: coupled nitrification-denitrification mediated by suspended particulate matter
- Zhu, Weijing, Wang, Cheng, Hill, Jaclyn M, He, Yangyang, Tao, Bangyi, Mao, Zhihua, Wu, Weixiang
- Authors: Zhu, Weijing , Wang, Cheng , Hill, Jaclyn M , He, Yangyang , Tao, Bangyi , Mao, Zhihua , Wu, Weixiang
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68368 , vital:29244 , https://0-doi.org.wam.seals.ac.za/10.1038/s41598-018-20688-4
- Description: In estuarine and coastal ecosystems, the majority of previous studies have considered coupled nitrification-denitrification (CND) processes to be exclusively sediment based, with little focus onsuspended particulate matter (SPM) in the water column. Here, we present evidence of CND processes in the water column of Hangzhou Bay, one of the largest macrotidal embayments in the world.
- Full Text:
- Date Issued: 2018
- Authors: Zhu, Weijing , Wang, Cheng , Hill, Jaclyn M , He, Yangyang , Tao, Bangyi , Mao, Zhihua , Wu, Weixiang
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68368 , vital:29244 , https://0-doi.org.wam.seals.ac.za/10.1038/s41598-018-20688-4
- Description: In estuarine and coastal ecosystems, the majority of previous studies have considered coupled nitrification-denitrification (CND) processes to be exclusively sediment based, with little focus onsuspended particulate matter (SPM) in the water column. Here, we present evidence of CND processes in the water column of Hangzhou Bay, one of the largest macrotidal embayments in the world.
- Full Text:
- Date Issued: 2018
- «
- ‹
- 1
- ›
- »