An exploratory study of the experiences of black teenage mothers
- Authors: Mpetshwa, Nomonde
- Date: 2001 , 2012-06-20
- Subjects: Teenage pregnancy , Teenage pregnancy -- South Africa -- Eastern Cape , Black teenage mothers -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:704 , http://hdl.handle.net/10962/d1006470 , Teenage pregnancy , Teenage pregnancy -- South Africa -- Eastern Cape , Black teenage mothers -- South Africa -- Eastern Cape
- Description: An exploratory descriptive design was used to explore the experiences of a sample of black teenage mothers of Libode, Ngqeleni and Port St Johns. A St Barnabas Hospital birth record register was used to select seven Xhosa speaking black teenage mothers, with children under a year old who have kept their children and are staying with their extended families. Qualitative interview was used to collect data from the abovementioned respondents. The data one want to use may not feasibly be available in any other form, so that asking people for their accounts, talking and listening to them, may be the only way to get at what you are interested in (Mason 1998:39). Qualitative interview was therefore used to collect data from the abovementioned respondents. Qualitative interview according to Mason (1998:38) involve one to one interaction as in this study, or a larger group, and it carries more advantages in data collection compared to other research tools. Some interesting information, which drew the researcher's attention, was gathered. Information such as the reaction by family members, community and its structures, and peers including teenage fathers, made the research more challenging. The anger showed by brothers of one of respondents raised the researcher's curiosity. Another interesting piece of information that was gathered was the negative reaction by the church. The researcher had no idea that the church can negatively involve itself in community affairs, but one of the respondents reported to have been encouraged by one of the church members to go on with her studies despite her pregnancy. The same applied to some schools, where pregnant teenagers were not allowed to continue schooling, while in other schools the same situation was allowed. The major findings were that, respondents have forfeited some of their favorite hobbies such as extra mural school activities, teenage activities and their lives have been negatively affected by their teenage motherhood in areas such as education, family relations, peer relations including their boyfriends and community. Again lack of support by people close to these young mothers including different professionals has also been identified. It has also transpired during this study that, teenagers can indeed be good mothers, but socioeconomic stress and lack of social support often prevent them from giving their babies a reasonable start in life. Amongst the recommendations made undertaking a bigger study has been suggested
- Full Text:
- Date Issued: 2001
- Authors: Mpetshwa, Nomonde
- Date: 2001 , 2012-06-20
- Subjects: Teenage pregnancy , Teenage pregnancy -- South Africa -- Eastern Cape , Black teenage mothers -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSocSc
- Identifier: vital:704 , http://hdl.handle.net/10962/d1006470 , Teenage pregnancy , Teenage pregnancy -- South Africa -- Eastern Cape , Black teenage mothers -- South Africa -- Eastern Cape
- Description: An exploratory descriptive design was used to explore the experiences of a sample of black teenage mothers of Libode, Ngqeleni and Port St Johns. A St Barnabas Hospital birth record register was used to select seven Xhosa speaking black teenage mothers, with children under a year old who have kept their children and are staying with their extended families. Qualitative interview was used to collect data from the abovementioned respondents. The data one want to use may not feasibly be available in any other form, so that asking people for their accounts, talking and listening to them, may be the only way to get at what you are interested in (Mason 1998:39). Qualitative interview was therefore used to collect data from the abovementioned respondents. Qualitative interview according to Mason (1998:38) involve one to one interaction as in this study, or a larger group, and it carries more advantages in data collection compared to other research tools. Some interesting information, which drew the researcher's attention, was gathered. Information such as the reaction by family members, community and its structures, and peers including teenage fathers, made the research more challenging. The anger showed by brothers of one of respondents raised the researcher's curiosity. Another interesting piece of information that was gathered was the negative reaction by the church. The researcher had no idea that the church can negatively involve itself in community affairs, but one of the respondents reported to have been encouraged by one of the church members to go on with her studies despite her pregnancy. The same applied to some schools, where pregnant teenagers were not allowed to continue schooling, while in other schools the same situation was allowed. The major findings were that, respondents have forfeited some of their favorite hobbies such as extra mural school activities, teenage activities and their lives have been negatively affected by their teenage motherhood in areas such as education, family relations, peer relations including their boyfriends and community. Again lack of support by people close to these young mothers including different professionals has also been identified. It has also transpired during this study that, teenagers can indeed be good mothers, but socioeconomic stress and lack of social support often prevent them from giving their babies a reasonable start in life. Amongst the recommendations made undertaking a bigger study has been suggested
- Full Text:
- Date Issued: 2001
The influence of a methylated-β-Cyclodextrin on the solubility and photostability of midazolam in aqueous solution
- Authors: Lebete, Mosimotsana Leah
- Date: 2001 , 2013-04-26
- Subjects: Midazolam -- Solubility
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3823 , http://hdl.handle.net/10962/d1005923 , Midazolam -- Solubility
- Description: Midazolam, used clinically as an anticonvulsant, anxiolytic, muscle relaxant and sedative is a photolabile imidazo-benzodiazepine which is marketed under the trade names Dormicum® and Hypnovel® as tablets and injectables. Because of an aqueous solubility of < 0.1 mg/ml above pH 4, the preparation of aqueous dosage formulations near physiological pH, requires a solubilizer. The aim of this study was thus to prepare a 10 mg/ml midazolam aqueous solution for topical application using randomly-methylated-pcyclodextrin (RAMEB), considered to be a suitable candidate as a solubilizer because of its absorption enhancing properties, and to investigate its effect on both the solubility and the photostability of midazolam. Solubility studies of midazolam (excess of 15 mg/ml) in the presence of 0, 5,10,20, 30% m/v of RAMEB at pH 5.0 and pH 5.8 (phosphate buffer) were undertaken and the results analyzed using a UV method validated for linearity, accuracy, precision and specificity. A stability-indicating HPLC method was developed and validated (precision and accuracy, linearity, range, limit of quantitation, specificity, robustness and ruggedness) for application to kinetic photostability studies and the identification of photodegradants by LC-MS. Forced degradation studies were carried out at concentrations of 0.5 mg/ml of midazolam instead of the target concentration of 10 mg/ml because of the acceleratory effect of the decreased concentration on the rate of photodegradation. The solutions of midazolam with and without RAMEB were irradiated at 550 W/m² for 12 hrs in order to degrade the drug to ± 10% of the original concentration. The UV method proved to be valid in terms of linearity with a correlation coefficient of 0.9998, precise and accurate, and specific for the determination of midazolam in the presence of RAMEB. The results of the phase solubility studies indicated that desired solubility of 10 mg/ml was achieved with 30% m/v RAMEB at pH 5.0. RAMEB slightly decreased the photostability of midazolam, the rate constants being 0.137 and 0.154 hr⁻¹ in the absence and presence of RAMEB, respectively. LC-MS analysis revealed that one of the major photoproducts in the presence and absence of RAMEB was N-desalkylflurazepam, a starting material in the synthesis of midazolam. RAMEB inhibited formation of some photoproducts and introduced two new photoproducts, a dimer and an addition product. The difference in the nature of these photoproducts formed may be attributed to the ability of RAMEB to provide conformational control and to stabilize free radicals. Although RAMEB improved the solubility of midazolam to the target concentration, photostability is decreased with the presence of different photoproducts. These studies have however provided information on the overall photostability of midazolam, the identity of its photodegradants and the photodegradation pathway in the presence and absence of RAMEB, and may be used for further method development and validation for the analysis of aqueous dosage forms containing RAMEB as a solubilizer. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Date Issued: 2001
- Authors: Lebete, Mosimotsana Leah
- Date: 2001 , 2013-04-26
- Subjects: Midazolam -- Solubility
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:3823 , http://hdl.handle.net/10962/d1005923 , Midazolam -- Solubility
- Description: Midazolam, used clinically as an anticonvulsant, anxiolytic, muscle relaxant and sedative is a photolabile imidazo-benzodiazepine which is marketed under the trade names Dormicum® and Hypnovel® as tablets and injectables. Because of an aqueous solubility of < 0.1 mg/ml above pH 4, the preparation of aqueous dosage formulations near physiological pH, requires a solubilizer. The aim of this study was thus to prepare a 10 mg/ml midazolam aqueous solution for topical application using randomly-methylated-pcyclodextrin (RAMEB), considered to be a suitable candidate as a solubilizer because of its absorption enhancing properties, and to investigate its effect on both the solubility and the photostability of midazolam. Solubility studies of midazolam (excess of 15 mg/ml) in the presence of 0, 5,10,20, 30% m/v of RAMEB at pH 5.0 and pH 5.8 (phosphate buffer) were undertaken and the results analyzed using a UV method validated for linearity, accuracy, precision and specificity. A stability-indicating HPLC method was developed and validated (precision and accuracy, linearity, range, limit of quantitation, specificity, robustness and ruggedness) for application to kinetic photostability studies and the identification of photodegradants by LC-MS. Forced degradation studies were carried out at concentrations of 0.5 mg/ml of midazolam instead of the target concentration of 10 mg/ml because of the acceleratory effect of the decreased concentration on the rate of photodegradation. The solutions of midazolam with and without RAMEB were irradiated at 550 W/m² for 12 hrs in order to degrade the drug to ± 10% of the original concentration. The UV method proved to be valid in terms of linearity with a correlation coefficient of 0.9998, precise and accurate, and specific for the determination of midazolam in the presence of RAMEB. The results of the phase solubility studies indicated that desired solubility of 10 mg/ml was achieved with 30% m/v RAMEB at pH 5.0. RAMEB slightly decreased the photostability of midazolam, the rate constants being 0.137 and 0.154 hr⁻¹ in the absence and presence of RAMEB, respectively. LC-MS analysis revealed that one of the major photoproducts in the presence and absence of RAMEB was N-desalkylflurazepam, a starting material in the synthesis of midazolam. RAMEB inhibited formation of some photoproducts and introduced two new photoproducts, a dimer and an addition product. The difference in the nature of these photoproducts formed may be attributed to the ability of RAMEB to provide conformational control and to stabilize free radicals. Although RAMEB improved the solubility of midazolam to the target concentration, photostability is decreased with the presence of different photoproducts. These studies have however provided information on the overall photostability of midazolam, the identity of its photodegradants and the photodegradation pathway in the presence and absence of RAMEB, and may be used for further method development and validation for the analysis of aqueous dosage forms containing RAMEB as a solubilizer. , KMBT_363 , Adobe Acrobat 9.53 Paper Capture Plug-in
- Full Text:
- Date Issued: 2001
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