New developments in the methodology available for the assessment of topical corticosteroid-induced skin blanching
- Haigh, John M, Smith, Eric W, Maibach, Howard I
- Authors: Haigh, John M , Smith, Eric W , Maibach, Howard I
- Date: 1998
- Language: English
- Type: text , Article
- Identifier: vital:6384 , http://hdl.handle.net/10962/d1006305
- Description: Since the publication of the previous edition of this book there have been considerable developments and controversy in the field of topical corticosteroid bioequivalence assessment. There has been considerable discussion in the literature concerning the use of the Minolta chromameter for the measurement of corticosteroid-induced skin blanching, as it is believed this instrument would produce more objective results than the visual grading procedure. These efforts culminated in the release of a guidance document from the Food and Drug Administration (FDA) detailing the procedures to be followed for the determination of topical corticosteroid bioequivalence using the chromameter. Since the promulgation of this document there have been challenges on the validity and scientific merit of the documented procedures, and recently the FDA itself conceded that it may be necessary to redefine some of the protocol evaluations. This chapter attempts to redefine the current standing of the two methods of response assessment.
- Full Text:
- Date Issued: 1998
- Authors: Haigh, John M , Smith, Eric W , Maibach, Howard I
- Date: 1998
- Language: English
- Type: text , Article
- Identifier: vital:6384 , http://hdl.handle.net/10962/d1006305
- Description: Since the publication of the previous edition of this book there have been considerable developments and controversy in the field of topical corticosteroid bioequivalence assessment. There has been considerable discussion in the literature concerning the use of the Minolta chromameter for the measurement of corticosteroid-induced skin blanching, as it is believed this instrument would produce more objective results than the visual grading procedure. These efforts culminated in the release of a guidance document from the Food and Drug Administration (FDA) detailing the procedures to be followed for the determination of topical corticosteroid bioequivalence using the chromameter. Since the promulgation of this document there have been challenges on the validity and scientific merit of the documented procedures, and recently the FDA itself conceded that it may be necessary to redefine some of the protocol evaluations. This chapter attempts to redefine the current standing of the two methods of response assessment.
- Full Text:
- Date Issued: 1998
The Marinkas Quellen Carbonatite Complex, southern Namibia: carbonatite magmatism with an uncontaminated depleted mantle signature in a continental setting
- Smithies, Robert H, Marsh, Julian S
- Authors: Smithies, Robert H , Marsh, Julian S
- Date: 1998
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149736 , vital:38879 , https://doi.org/10.1016/S0009-2541(98)00029-1
- Description: The Marinkas Quellen Carbonatite Complex, in southern Namibia, forms part of the ca. 490–550 Ma Kuboos-Bremen Igneous Province, a zone of alkaline igneous rocks that intrude the Mesoproterzoic to Paleoproterozoic Namaqualand Metamorphic Province and Neoproterozoic platform sediments. The carbonatite complex includes Ca-rich, Mg-rich and Fe-rich carbonatites as well as late ferrocarbonatite dykes that show extreme enrichments in Mn, REE and Th. Compared to most carbonatites, those at Marinkas Quellen are generally depleted in most trace elements, particularly Ba and the LREE.
- Full Text: false
- Date Issued: 1998
- Authors: Smithies, Robert H , Marsh, Julian S
- Date: 1998
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149736 , vital:38879 , https://doi.org/10.1016/S0009-2541(98)00029-1
- Description: The Marinkas Quellen Carbonatite Complex, in southern Namibia, forms part of the ca. 490–550 Ma Kuboos-Bremen Igneous Province, a zone of alkaline igneous rocks that intrude the Mesoproterzoic to Paleoproterozoic Namaqualand Metamorphic Province and Neoproterozoic platform sediments. The carbonatite complex includes Ca-rich, Mg-rich and Fe-rich carbonatites as well as late ferrocarbonatite dykes that show extreme enrichments in Mn, REE and Th. Compared to most carbonatites, those at Marinkas Quellen are generally depleted in most trace elements, particularly Ba and the LREE.
- Full Text: false
- Date Issued: 1998
A new luminous cardinalfish of the genus Apogon (Perciformes:Apogonidae) from the western Pacific Ocean
- Gon, O (Ofer), 1949-, Allen, Gerald R, J.L.B. Smith Institute of Ichthyology
- Authors: Gon, O (Ofer), 1949- , Allen, Gerald R , J.L.B. Smith Institute of Ichthyology
- Date: 1998-11
- Subjects: Apogon -- Pacific Ocean -- Classification , Apogon -- Pacific Ocean -- Identification , Bioluminescence -- Pacific Ocean
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/71022 , vital:29770 , Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB)) Periodicals Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB))
- Description: Online version of original print edition of the Special Publication of the J.L.B. Smith Institute of Ichthyology; No. 62 , A new species of cardinalfish, Apogon photogaster is described based on 11 specimens from Madang Lagoon in Papua New Guinea and Galoc Island in the Philippines. This new species has 15 pectoral rays, 2 predorsal scales, 15-18 gill-rakers (8-9 developed), and 7 gill-rakers on the ceratobranchial o f the first gill-arch. It has a unique bioluminescent system, including a light organ branching forward from the second loop of the intestine and a diffuser organ along the ventrolateral part of the body.
- Full Text:
- Date Issued: 1998-11
- Authors: Gon, O (Ofer), 1949- , Allen, Gerald R , J.L.B. Smith Institute of Ichthyology
- Date: 1998-11
- Subjects: Apogon -- Pacific Ocean -- Classification , Apogon -- Pacific Ocean -- Identification , Bioluminescence -- Pacific Ocean
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/71022 , vital:29770 , Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB)) Periodicals Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB))
- Description: Online version of original print edition of the Special Publication of the J.L.B. Smith Institute of Ichthyology; No. 62 , A new species of cardinalfish, Apogon photogaster is described based on 11 specimens from Madang Lagoon in Papua New Guinea and Galoc Island in the Philippines. This new species has 15 pectoral rays, 2 predorsal scales, 15-18 gill-rakers (8-9 developed), and 7 gill-rakers on the ceratobranchial o f the first gill-arch. It has a unique bioluminescent system, including a light organ branching forward from the second loop of the intestine and a diffuser organ along the ventrolateral part of the body.
- Full Text:
- Date Issued: 1998-11
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