Establishing computational approaches towards identifying malarial allosteric modulators: a case study of plasmodium falciparum hsp70s
- Amusengeri, Arnold, Astl, Lindy, Lobb, Kevin A, Verkhivker, Gennady M, Tastan Bishop, Özlem
- Authors: Amusengeri, Arnold , Astl, Lindy , Lobb, Kevin A , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163000 , vital:41003 , https://doi.org/10.3390/ijms20225574
- Description: Combating malaria is almost a never-ending battle, as Plasmodium parasites develop resistance to the drugs used against them, as observed recently in artemisinin-based combination therapies. The main concern now is if the resistant parasite strains spread from Southeast Asia to Africa, the continent hosting most malaria cases. To prevent catastrophic results, we need to find non-conventional approaches. Allosteric drug targeting sites and modulators might be a new hope for malarial treatments. Heat shock proteins (HSPs) are potential malarial drug targets and have complex allosteric control mechanisms. Yet, studies on designing allosteric modulators against them are limited. Here, we identified allosteric modulators (SANC190 and SANC651) against P. falciparum Hsp70-1 and Hsp70-x, affecting the conformational dynamics of the proteins, delicately balanced by the endogenous ligands. Previously, we established a pipeline to identify allosteric sites and modulators. This study also further investigated alternative approaches to speed up the process by comparing all atom molecular dynamics simulations and dynamic residue network analysis with the coarse-grained (CG) versions of the calculations. Betweenness centrality (BC) profiles for PfHsp70-1 and PfHsp70-x derived from CG simulations not only revealed similar trends but also pointed to the same functional regions and specific residues corresponding to BC profile peaks.
- Full Text:
- Date Issued: 2019
- Authors: Amusengeri, Arnold , Astl, Lindy , Lobb, Kevin A , Verkhivker, Gennady M , Tastan Bishop, Özlem
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163000 , vital:41003 , https://doi.org/10.3390/ijms20225574
- Description: Combating malaria is almost a never-ending battle, as Plasmodium parasites develop resistance to the drugs used against them, as observed recently in artemisinin-based combination therapies. The main concern now is if the resistant parasite strains spread from Southeast Asia to Africa, the continent hosting most malaria cases. To prevent catastrophic results, we need to find non-conventional approaches. Allosteric drug targeting sites and modulators might be a new hope for malarial treatments. Heat shock proteins (HSPs) are potential malarial drug targets and have complex allosteric control mechanisms. Yet, studies on designing allosteric modulators against them are limited. Here, we identified allosteric modulators (SANC190 and SANC651) against P. falciparum Hsp70-1 and Hsp70-x, affecting the conformational dynamics of the proteins, delicately balanced by the endogenous ligands. Previously, we established a pipeline to identify allosteric sites and modulators. This study also further investigated alternative approaches to speed up the process by comparing all atom molecular dynamics simulations and dynamic residue network analysis with the coarse-grained (CG) versions of the calculations. Betweenness centrality (BC) profiles for PfHsp70-1 and PfHsp70-x derived from CG simulations not only revealed similar trends but also pointed to the same functional regions and specific residues corresponding to BC profile peaks.
- Full Text:
- Date Issued: 2019
Playing broken telephone with student feedback: the possibilities and issues of transformation within a South African case of a collegial rationality model of evaluation
- Authors: Belluigi, Dina Z
- Date: 2013
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66943 , vital:29003 , https://doi.org/10.1016/B978-1-84334-655-5.50001-5
- Description: publisher version , Drawing on the case of a small South African university which espouses a social justice approach to transformation, this chapter considers the possibilities and challenges created for student feedback within an institutional context that gives the individual lecturer a large degree of autonomy in evaluation. The chapter looks at some of the dominant perceptions of student feedback in addition to how it is collected and utilised, by referring to the institution’s policies and guideline documents; institutional research conducted with course coordinators; responses elicited from 40 lecturers on the issues outlined in this chapter; the author’s own reflections as a staff developer in the institution; and specific examples of good practice from lecturers situated within social science disciplines. The emerging concerns which structured this discussion are: the impact of student feedback on improving quality; enabling student voice; increasing student ownership; and the educational value of evaluation processes.
- Full Text: false
- Date Issued: 2013
- Authors: Belluigi, Dina Z
- Date: 2013
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66943 , vital:29003 , https://doi.org/10.1016/B978-1-84334-655-5.50001-5
- Description: publisher version , Drawing on the case of a small South African university which espouses a social justice approach to transformation, this chapter considers the possibilities and challenges created for student feedback within an institutional context that gives the individual lecturer a large degree of autonomy in evaluation. The chapter looks at some of the dominant perceptions of student feedback in addition to how it is collected and utilised, by referring to the institution’s policies and guideline documents; institutional research conducted with course coordinators; responses elicited from 40 lecturers on the issues outlined in this chapter; the author’s own reflections as a staff developer in the institution; and specific examples of good practice from lecturers situated within social science disciplines. The emerging concerns which structured this discussion are: the impact of student feedback on improving quality; enabling student voice; increasing student ownership; and the educational value of evaluation processes.
- Full Text: false
- Date Issued: 2013
Creating a virtual classroom: evaluating the use of online discussion forums to increase teaching and learning activities in an introductory accounting class
- Authors: Bezuidenhout, L Peta
- Date: 2008
- Language: English
- Type: Conference paper
- Identifier: vital:6082 , http://hdl.handle.net/10962/d1008586
- Description: In teaching large classes, the educationally beneficial informal interaction between students and between lecturer and students is generally reduced, while effective use of both students' and lecturer's time is often a challenge. During student consultations, especially over the already stressful test and examination periods, many of the questions asked by the students are the same or similar. The lecturer needs to respond to each query by providing the same detailed explanation for the problem, resulting in ineffective use of time for the lecturer, while students waste time waiting for an appointment, or more often, simply don't bother to follow up on any queries they may have. Having a social presence is important for students' cognitive development, but in a large class posing questions or interrogating issues during a lecture appears to be challenging for many students. It is often not easy for students to initiate discussions or establish relationships with peers or the lecturer due to feelings of vulnerability and due to the size and impersonal atmosphere of the lecture theatre. This paper deals with the introduction of online discussion forums in an introductory accounting course and the benefits and problems experienced by the students, tutors and lecturer as a result thereof. Feedback received from these participants is discussed. The introduction and use of these forums resulted in a virtual classroom being created, where significantly more teaching and learning activities took place, to the benefit of all participants. Participation could have been peripheral - in the form of simply reading discussions; or active – through posting questions, or responding to questions.
- Full Text:
- Date Issued: 2008
- Authors: Bezuidenhout, L Peta
- Date: 2008
- Language: English
- Type: Conference paper
- Identifier: vital:6082 , http://hdl.handle.net/10962/d1008586
- Description: In teaching large classes, the educationally beneficial informal interaction between students and between lecturer and students is generally reduced, while effective use of both students' and lecturer's time is often a challenge. During student consultations, especially over the already stressful test and examination periods, many of the questions asked by the students are the same or similar. The lecturer needs to respond to each query by providing the same detailed explanation for the problem, resulting in ineffective use of time for the lecturer, while students waste time waiting for an appointment, or more often, simply don't bother to follow up on any queries they may have. Having a social presence is important for students' cognitive development, but in a large class posing questions or interrogating issues during a lecture appears to be challenging for many students. It is often not easy for students to initiate discussions or establish relationships with peers or the lecturer due to feelings of vulnerability and due to the size and impersonal atmosphere of the lecture theatre. This paper deals with the introduction of online discussion forums in an introductory accounting course and the benefits and problems experienced by the students, tutors and lecturer as a result thereof. Feedback received from these participants is discussed. The introduction and use of these forums resulted in a virtual classroom being created, where significantly more teaching and learning activities took place, to the benefit of all participants. Participation could have been peripheral - in the form of simply reading discussions; or active – through posting questions, or responding to questions.
- Full Text:
- Date Issued: 2008
Risk and benefit as functions of savings and loan clubs: an examination of the importance of rotating credit associations for poor women in Rhini
- Authors: Buijs, Gina
- Date: 1995
- Subjects: Africans -- Economic conditions Rhini (Grahamstown, South Africa) -- Social conditions Savings and loan associations -- South Africa -- Grahamstown Savings and loan associations -- South Africa Urban poor -- South Africa Women -- South Africa -- Grahamstown -- Economic conditions Women -- South Africa -- Economic conditions Black people -- South Africa -- Grahamstown Grahamstown (South Africa) -- Economic conditions
- Language: English
- Type: Manuscript , Text
- Identifier: http://hdl.handle.net/10962/2498 , vital:20298
- Description: Paper presented at an ISER Seminar, 25th April 1995: This paper examines the implications of risk taking in the context of rotating credit associations popular among poor women in Rhini. Mary Douglas notes that in the 19th century when the theory of risk taking became important in economics, humans were thought to be risk averse because they chose according to a pleasure calculus. In the 18th century the idea of risk was neutral: it took account of the probability of gains and losses. The concept originally emerged in the 17th century in the context of gambling. Risk then means the probability of an event occurring, combined with the magnitude of the losses and gains which would be entailed. She comments (1992:31) that the evaluation of the outcome is a political, aesthetic and moral matter. , Digitised by Rhodes University Library on behalf of the Institute of Social and Economic Research (ISER)
- Full Text:
- Date Issued: 1995
- Authors: Buijs, Gina
- Date: 1995
- Subjects: Africans -- Economic conditions Rhini (Grahamstown, South Africa) -- Social conditions Savings and loan associations -- South Africa -- Grahamstown Savings and loan associations -- South Africa Urban poor -- South Africa Women -- South Africa -- Grahamstown -- Economic conditions Women -- South Africa -- Economic conditions Black people -- South Africa -- Grahamstown Grahamstown (South Africa) -- Economic conditions
- Language: English
- Type: Manuscript , Text
- Identifier: http://hdl.handle.net/10962/2498 , vital:20298
- Description: Paper presented at an ISER Seminar, 25th April 1995: This paper examines the implications of risk taking in the context of rotating credit associations popular among poor women in Rhini. Mary Douglas notes that in the 19th century when the theory of risk taking became important in economics, humans were thought to be risk averse because they chose according to a pleasure calculus. In the 18th century the idea of risk was neutral: it took account of the probability of gains and losses. The concept originally emerged in the 17th century in the context of gambling. Risk then means the probability of an event occurring, combined with the magnitude of the losses and gains which would be entailed. She comments (1992:31) that the evaluation of the outcome is a political, aesthetic and moral matter. , Digitised by Rhodes University Library on behalf of the Institute of Social and Economic Research (ISER)
- Full Text:
- Date Issued: 1995
The story of Jane G
- Authors: Cape Action League (C.A.L.)
- Date: 1989
- Subjects: Champion, A W G (Allison Wessels George), 1893-1975 , Capitalism -- South Africa , Civil rights movements -- South Africa , Trade Unions -- South Africa , Labour unions -- South Africa
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/60143 , vital:27741
- Description: Jane G, first appeared as a series in Solidarity, the mouthpiece of the Cape Action League. The series was read by activists in community, student, youth and worker organisations. At the request of readers, the Cape Action League decided to publish the series as a booklet. The book is written in easy English in order for it to be used by workers and their allies as an instrument for active struggle against all forms of oppression and exploitation. The story of Jane G has its roots in the daily experiences of an ordinary black working mother living in South Africa/Azania. She is the mother you meet at the bus stop, meet in the taxi, talk to at the corner shop or prayer meeting. In this series, Jane G’s struggle is typical of the millions of workers suffering a similar fate in our country. Jane speaks of the hardship she faces under the exploitative cycle of earning low wages and paying high rents. The burden of working long hours and paying high prices for basic food in order to look after her family. She finds relief by joining the Clothing Workers’ Union which organises workers at the Rex-Tex factory where she works.
- Full Text:
- Date Issued: 1989
- Authors: Cape Action League (C.A.L.)
- Date: 1989
- Subjects: Champion, A W G (Allison Wessels George), 1893-1975 , Capitalism -- South Africa , Civil rights movements -- South Africa , Trade Unions -- South Africa , Labour unions -- South Africa
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/60143 , vital:27741
- Description: Jane G, first appeared as a series in Solidarity, the mouthpiece of the Cape Action League. The series was read by activists in community, student, youth and worker organisations. At the request of readers, the Cape Action League decided to publish the series as a booklet. The book is written in easy English in order for it to be used by workers and their allies as an instrument for active struggle against all forms of oppression and exploitation. The story of Jane G has its roots in the daily experiences of an ordinary black working mother living in South Africa/Azania. She is the mother you meet at the bus stop, meet in the taxi, talk to at the corner shop or prayer meeting. In this series, Jane G’s struggle is typical of the millions of workers suffering a similar fate in our country. Jane speaks of the hardship she faces under the exploitative cycle of earning low wages and paying high rents. The burden of working long hours and paying high prices for basic food in order to look after her family. She finds relief by joining the Clothing Workers’ Union which organises workers at the Rex-Tex factory where she works.
- Full Text:
- Date Issued: 1989
HSP90 interacts with the fibronectin N-terminal domains and increases matrix formation:
- Chakraborty, Abir, Boel, Natasha M-E, Edkins, Adrienne L
- Authors: Chakraborty, Abir , Boel, Natasha M-E , Edkins, Adrienne L
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165407 , vital:41241 , https://doi.org/10.3390/cells9020272
- Description: Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that controls the function and stability of a wide range of cellular client proteins. Fibronectin (FN) is an extracellular client protein of HSP90, and exogenous HSP90 or inhibitors of HSP90 alter the morphology of the extracellular matrix. Here, we further characterized the HSP90 and FN interaction. FN bound to the M domain of HSP90 and interacted with both the open and closed HSP90 conformations; and the interaction was reduced in the presence of sodium molybdate. HSP90 interacted with the N-terminal regions of FN, which are known to be important for matrix assembly.
- Full Text:
- Date Issued: 2020
- Authors: Chakraborty, Abir , Boel, Natasha M-E , Edkins, Adrienne L
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165407 , vital:41241 , https://doi.org/10.3390/cells9020272
- Description: Heat shock protein 90 (HSP90) is an evolutionarily conserved chaperone protein that controls the function and stability of a wide range of cellular client proteins. Fibronectin (FN) is an extracellular client protein of HSP90, and exogenous HSP90 or inhibitors of HSP90 alter the morphology of the extracellular matrix. Here, we further characterized the HSP90 and FN interaction. FN bound to the M domain of HSP90 and interacted with both the open and closed HSP90 conformations; and the interaction was reduced in the presence of sodium molybdate. HSP90 interacted with the N-terminal regions of FN, which are known to be important for matrix assembly.
- Full Text:
- Date Issued: 2020
Stop privatisation - Join the campaign
- COSATU
- Authors: COSATU
- Date: June 1991
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/135389 , vital:37263
- Description: Privatisation is when government hands over the management or assets of government services to private interests. Privatised services don't provide well for the poor, who can't pay, because private interests must make profits. Government says it will ensure the poor get good services through contracts and regulations - but it doesn't have capacity to enforce them. Privatisation makes it harder to maintain cross subsidies. Cross subsidies mean rich communities or industry pay more, so that poor households can pay less. Getting rid of cross-subsidies tends to make the prices for services for the poor go up. Privatised companies don't take the broader economic needs of the country into account, for instance by buying goods locally as a way to create jobs, and providing affordable services in remote regions.
- Full Text:
- Date Issued: June 1991
- Authors: COSATU
- Date: June 1991
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/135389 , vital:37263
- Description: Privatisation is when government hands over the management or assets of government services to private interests. Privatised services don't provide well for the poor, who can't pay, because private interests must make profits. Government says it will ensure the poor get good services through contracts and regulations - but it doesn't have capacity to enforce them. Privatisation makes it harder to maintain cross subsidies. Cross subsidies mean rich communities or industry pay more, so that poor households can pay less. Getting rid of cross-subsidies tends to make the prices for services for the poor go up. Privatised companies don't take the broader economic needs of the country into account, for instance by buying goods locally as a way to create jobs, and providing affordable services in remote regions.
- Full Text:
- Date Issued: June 1991
Behind the barricades
- COSATU
- Authors: COSATU
- Date: 1987
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/172098 , vital:42159
- Description: I saw a badly injured and handcuffed man pushed down the stairs of Cosatu House in central Johannesburg during this week’s police siege. After hitting the bottom of the stairs head first with a dull thud, he lay still. A young policeman moved up to him and hit him once on the rib with rubber pick-handle. The man didn't stir. He was dragged on the ground to a police truck before being thrown in head first.
- Full Text:
- Date Issued: 1987
- Authors: COSATU
- Date: 1987
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/172098 , vital:42159
- Description: I saw a badly injured and handcuffed man pushed down the stairs of Cosatu House in central Johannesburg during this week’s police siege. After hitting the bottom of the stairs head first with a dull thud, he lay still. A young policeman moved up to him and hit him once on the rib with rubber pick-handle. The man didn't stir. He was dragged on the ground to a police truck before being thrown in head first.
- Full Text:
- Date Issued: 1987
COSATU Constitution as amended at the 4th National Congress
- COSATU
- Authors: COSATU
- Date: 1991
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/135027 , vital:37228
- Description: We the Trade Union representatives here present firmly commit ourselves to a unified democratic South Africa, free of oppression and economic exploitation. We believe that this could only be achieved under the leadership of a united working class. Our history has taught us that to achieve this goal we will have to carry out the following tasks : Organise the unorganised and build effective trade unions based on the democratic organisation of workers in the factories, mines, shops, farms and other workplaces. Organise national industrial trade unions, financed and controlled by their worker members through democratically committees. Unify these industrial unions into a national worker controlled federation. Combat the divisions amongst the workers of South Africa and unite them into a strong and confident working class. Encourage democratic worker organisation and leadership in all spheres of our society together with other progressive sectors of the community. Reinforce and encourage progressive international worker contact and solidarity so as to assist one another in our struggle. We call on all those who identify with this commitment to join us and the workers whom we represent, as comrades in the struggle ahead. We call on all trade unions to strive to unite their members in their ranks without discrimination and prejudice, and therefore resolve that this federation shall determinedly seek to further and protect the interests of all workers and that its guiding motto shall be the universal slogan of working class solidarity: "An injury to one is an injury to all".
- Full Text:
- Date Issued: 1991
- Authors: COSATU
- Date: 1991
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/135027 , vital:37228
- Description: We the Trade Union representatives here present firmly commit ourselves to a unified democratic South Africa, free of oppression and economic exploitation. We believe that this could only be achieved under the leadership of a united working class. Our history has taught us that to achieve this goal we will have to carry out the following tasks : Organise the unorganised and build effective trade unions based on the democratic organisation of workers in the factories, mines, shops, farms and other workplaces. Organise national industrial trade unions, financed and controlled by their worker members through democratically committees. Unify these industrial unions into a national worker controlled federation. Combat the divisions amongst the workers of South Africa and unite them into a strong and confident working class. Encourage democratic worker organisation and leadership in all spheres of our society together with other progressive sectors of the community. Reinforce and encourage progressive international worker contact and solidarity so as to assist one another in our struggle. We call on all those who identify with this commitment to join us and the workers whom we represent, as comrades in the struggle ahead. We call on all trade unions to strive to unite their members in their ranks without discrimination and prejudice, and therefore resolve that this federation shall determinedly seek to further and protect the interests of all workers and that its guiding motto shall be the universal slogan of working class solidarity: "An injury to one is an injury to all".
- Full Text:
- Date Issued: 1991
Procedural meanings of well in a corpus of Xhosa English
- Authors: De Klerk, Vivian A
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6128 , http://hdl.handle.net/10962/d1011579
- Description: This article explores the use of the pragmatic marker well in a large corpus of the discourse of non-mother tongue speakers of Xhosa English, which is a sub-variety of Black South African English. A brief overview of discourse markers in general and of well in particular is provided, and the problems they pose to linguists in terms of difficulties in defining their syntactic, semantic and pragmatic properties are examined. After a brief description of the nature of the corpus of Xhosa English on which the study is based, and of the methodological approach which was followed, the rest of the article focuses on a fairly detailed exposition of the overall trends in contextualised uses and procedural meanings of well in the corpus, along with examples. Some (limited) parallels are drawn between the use of well in XE and other English corpora, in order to highlight the problems experienced by L2 learners in acquiring discourse markers.
- Full Text:
- Date Issued: 2005
- Authors: De Klerk, Vivian A
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6128 , http://hdl.handle.net/10962/d1011579
- Description: This article explores the use of the pragmatic marker well in a large corpus of the discourse of non-mother tongue speakers of Xhosa English, which is a sub-variety of Black South African English. A brief overview of discourse markers in general and of well in particular is provided, and the problems they pose to linguists in terms of difficulties in defining their syntactic, semantic and pragmatic properties are examined. After a brief description of the nature of the corpus of Xhosa English on which the study is based, and of the methodological approach which was followed, the rest of the article focuses on a fairly detailed exposition of the overall trends in contextualised uses and procedural meanings of well in the corpus, along with examples. Some (limited) parallels are drawn between the use of well in XE and other English corpora, in order to highlight the problems experienced by L2 learners in acquiring discourse markers.
- Full Text:
- Date Issued: 2005
Constructing a cardinal measure of democratic development in a transition polity: the Nigerian example
- Dinneya, Godson E, Tsegaye, Asrat
- Authors: Dinneya, Godson E , Tsegaye, Asrat
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6076 , http://hdl.handle.net/10962/d1003837
- Description: Existing measures of the level of democracy present in a given state treat democracy as a product and therefore place undue emphasis on actual freedoms enjoyed by the citizens of the country. In transition polities where the actual levels of freedom are low despite continuing efforts to democratize, democracy should be seen as a process rather than a product. A measure that dilutes the end product to capture today's struggles against undemocratic structures and policies does so in order to recognize the foundations these inputs lay for future democratic development. Nigeria exemplifies the many polities in transition on the African continent. This essay looks at the major political events that typify the processes of power change, quality of governance, political environment and democratic dividends, and uses them to construct democratization indices to determine the pattern and level of democratization in Nigeria since political independence. This exercise sets the stage for assessing the impacts of various dimensions of democratization on the performance of the Nigerian economy.
- Full Text:
- Date Issued: 2004
- Authors: Dinneya, Godson E , Tsegaye, Asrat
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6076 , http://hdl.handle.net/10962/d1003837
- Description: Existing measures of the level of democracy present in a given state treat democracy as a product and therefore place undue emphasis on actual freedoms enjoyed by the citizens of the country. In transition polities where the actual levels of freedom are low despite continuing efforts to democratize, democracy should be seen as a process rather than a product. A measure that dilutes the end product to capture today's struggles against undemocratic structures and policies does so in order to recognize the foundations these inputs lay for future democratic development. Nigeria exemplifies the many polities in transition on the African continent. This essay looks at the major political events that typify the processes of power change, quality of governance, political environment and democratic dividends, and uses them to construct democratization indices to determine the pattern and level of democratization in Nigeria since political independence. This exercise sets the stage for assessing the impacts of various dimensions of democratization on the performance of the Nigerian economy.
- Full Text:
- Date Issued: 2004
Contrasting spatial heterogeneity of sessile organisms within mussel (Perna perna L.) beds in relation to topographic variability
- Erlandsson, J, McQuaid, Christopher D, Kostylev, V E
- Authors: Erlandsson, J , McQuaid, Christopher D , Kostylev, V E
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6949 , http://hdl.handle.net/10962/d1011979
- Description: We examined the spatial heterogeneity in three sessile rocky shore organisms, the mussel Perna perna, the barnacle Octomeris angulosa (Sowerby) and the red alga Gelidium pristoides (Turn.) at a range of continuous local scales along horizontal transects within mid- and upper mussel beds of South African shores. We also examined the relationships between variability of organisms and topographic features (rock depressions, slope, aspect), and between mussel, barnacle and algal variability over the same scales. To estimate spatial heterogeneity, we analyzed scaling properties of semivariograms using a fractal approach. Relationships between different variables at the different scales were examined by cross-semivariograms. Spatial dependence of P. perna variability increased with spatial dependence of topographic variability, so that scaling regions of mussel and topographic distributions corresponded well. This relationship often improved with larger local scales (mussel cover increased with depressions, steeper slope and aspect towards waves), while at smaller spatial scales, variability in mussel cover was less well explained by variability in topography. The variability of the barnacle O. angulosa exhibited spatial dependence, even on topographically unstructured shores. In contrast, the distribution of the alga G. pristoides revealed high fractal dimensions, showing spatial independence on topographically unstructured shores. Algae also showed a very strong negative relationship with mussels at most local scales, and a negative relationship with barnacles in upper zones, especially at larger local scales. Barnacles may show clear spatial dependence because of hydrodynamics (at larger local scales) and the need to find a future mate in close proximity (at smaller local scales), while algae may show a strong negative relationship with mussels because of competition for space.
- Full Text:
- Date Issued: 2005
- Authors: Erlandsson, J , McQuaid, Christopher D , Kostylev, V E
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6949 , http://hdl.handle.net/10962/d1011979
- Description: We examined the spatial heterogeneity in three sessile rocky shore organisms, the mussel Perna perna, the barnacle Octomeris angulosa (Sowerby) and the red alga Gelidium pristoides (Turn.) at a range of continuous local scales along horizontal transects within mid- and upper mussel beds of South African shores. We also examined the relationships between variability of organisms and topographic features (rock depressions, slope, aspect), and between mussel, barnacle and algal variability over the same scales. To estimate spatial heterogeneity, we analyzed scaling properties of semivariograms using a fractal approach. Relationships between different variables at the different scales were examined by cross-semivariograms. Spatial dependence of P. perna variability increased with spatial dependence of topographic variability, so that scaling regions of mussel and topographic distributions corresponded well. This relationship often improved with larger local scales (mussel cover increased with depressions, steeper slope and aspect towards waves), while at smaller spatial scales, variability in mussel cover was less well explained by variability in topography. The variability of the barnacle O. angulosa exhibited spatial dependence, even on topographically unstructured shores. In contrast, the distribution of the alga G. pristoides revealed high fractal dimensions, showing spatial independence on topographically unstructured shores. Algae also showed a very strong negative relationship with mussels at most local scales, and a negative relationship with barnacles in upper zones, especially at larger local scales. Barnacles may show clear spatial dependence because of hydrodynamics (at larger local scales) and the need to find a future mate in close proximity (at smaller local scales), while algae may show a strong negative relationship with mussels because of competition for space.
- Full Text:
- Date Issued: 2005
Descriptions of two new species of Hetereleotris (Pisces: Gobiidae) from the western Indian Ocean, with discussion of related species
- Hoese, Douglass F, J.L.B. Smith Institute of Ichthyology
- Authors: Hoese, Douglass F , J.L.B. Smith Institute of Ichthyology
- Date: 1986-09
- Subjects: Gobiidae -- Classification
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/70228 , vital:29636 , Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB)) Periodicals Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB))
- Description: Online version of original print edition of the Special Publication of the J.L.B. Smith Institute of Ichthyology; No. 41 , Thirteen species of the genus Hetereleotris are recognized from the Indian Ocean. Two of the species are described as new. H. poecila (Fowler) is recorded for the first time from the Indian Ocean, and H. vulgaris (Klunzinger) is recorded from the Mediterranean. Specimens of H. zonata from India and Pakistan were found to differ in several features from specimens from South Africa. A key is given to the species from the western Indian Ocean. Diagnoses and a primary synonymy are given for each of the 11 previously described species.
- Full Text:
- Date Issued: 1986-09
- Authors: Hoese, Douglass F , J.L.B. Smith Institute of Ichthyology
- Date: 1986-09
- Subjects: Gobiidae -- Classification
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/70228 , vital:29636 , Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB)) Periodicals Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB))
- Description: Online version of original print edition of the Special Publication of the J.L.B. Smith Institute of Ichthyology; No. 41 , Thirteen species of the genus Hetereleotris are recognized from the Indian Ocean. Two of the species are described as new. H. poecila (Fowler) is recorded for the first time from the Indian Ocean, and H. vulgaris (Klunzinger) is recorded from the Mediterranean. Specimens of H. zonata from India and Pakistan were found to differ in several features from specimens from South Africa. A key is given to the species from the western Indian Ocean. Diagnoses and a primary synonymy are given for each of the 11 previously described species.
- Full Text:
- Date Issued: 1986-09
Phenylpropanolamine hydrochloride
- Kanfer, Isadore, Haigh, John M, Dowse, Roslind
- Authors: Kanfer, Isadore , Haigh, John M , Dowse, Roslind
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6385 , http://hdl.handle.net/10962/d1006306
- Description: Phenylpropanolamine hydrochloride belongs to the sympathomimetic amine class of drugs and is structurally related to ephedrine hydrochloride. Its synthesis was first reported in 1910 and the first American patent was registered in 1939. The effects of phenylpropanolamine hydrochloride are largely the result of alpha-adrenergic agonist activity resulting from both direct stimulation of adrenergic receptors and release of neuronal norepinephrine. The principal adverse effect of phenylpropanolamine hydrochloride is dose-related hypertension and ventricular arrhythmia has been described. Phenylpropanolamine hydrochloride is widely used as a decongestant and it has been used as an anorectic agent for over 40 years. A report in 1939 described its effect as an hypertensive agent when administered parenterally.
- Full Text:
- Date Issued: 1983
- Authors: Kanfer, Isadore , Haigh, John M , Dowse, Roslind
- Date: 1983
- Language: English
- Type: Article
- Identifier: vital:6385 , http://hdl.handle.net/10962/d1006306
- Description: Phenylpropanolamine hydrochloride belongs to the sympathomimetic amine class of drugs and is structurally related to ephedrine hydrochloride. Its synthesis was first reported in 1910 and the first American patent was registered in 1939. The effects of phenylpropanolamine hydrochloride are largely the result of alpha-adrenergic agonist activity resulting from both direct stimulation of adrenergic receptors and release of neuronal norepinephrine. The principal adverse effect of phenylpropanolamine hydrochloride is dose-related hypertension and ventricular arrhythmia has been described. Phenylpropanolamine hydrochloride is widely used as a decongestant and it has been used as an anorectic agent for over 40 years. A report in 1939 described its effect as an hypertensive agent when administered parenterally.
- Full Text:
- Date Issued: 1983
When is it legitimate to use images in moral arguments? The use of foetal imagery in anti-abortion campaigns as an exemplar of an illegitimate instance of a legitimate practice
- Kelland, Lindsay, Macleod, Catriona I
- Authors: Kelland, Lindsay , Macleod, Catriona I
- Date: 2015
- Language: English
- Type: Article
- Identifier: vital:6305 , http://hdl.handle.net/10962/d1016146
- Description: We aim to interrogate when the use of images in moral persuasion is legitimate. First, we put forward a number of accounts which purport to show that we can use tools other than logical argumentation to convince others, that such tools evoke affective responses and that these responses have authority in the moral domain. Second, we turn to Sarah McGrath’s account, which focuses on the use of imagery as a means to morally persuade. McGrath discusses 4 objections to the use of imagery, and outlines responses that may be used to legitimate the use of imagery in moral arguments. Assuming that we accept her account and that the invocation of affect has authority in the moral domain, we, using McGrath’s responses, examine whether the use of foetal imagery in anti-abortion campaigns is a legitimate instance of this practice.
- Full Text:
- Date Issued: 2015
- Authors: Kelland, Lindsay , Macleod, Catriona I
- Date: 2015
- Language: English
- Type: Article
- Identifier: vital:6305 , http://hdl.handle.net/10962/d1016146
- Description: We aim to interrogate when the use of images in moral persuasion is legitimate. First, we put forward a number of accounts which purport to show that we can use tools other than logical argumentation to convince others, that such tools evoke affective responses and that these responses have authority in the moral domain. Second, we turn to Sarah McGrath’s account, which focuses on the use of imagery as a means to morally persuade. McGrath discusses 4 objections to the use of imagery, and outlines responses that may be used to legitimate the use of imagery in moral arguments. Assuming that we accept her account and that the invocation of affect has authority in the moral domain, we, using McGrath’s responses, examine whether the use of foetal imagery in anti-abortion campaigns is a legitimate instance of this practice.
- Full Text:
- Date Issued: 2015
Conscientious objection to performing same-sex marriage in South Africa
- Authors: Kruuse, Helen
- Date: 2014
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/129186 , vital:36228 , https://doi.org/10.1093/lawfam/ebu001
- Description: This article considers whether public servants should be exempt from South Africa’s equality provisions and anti-discrimination legislation in solemnizing same-sex marriages. In order to deal with this question, the article analyses the treatment of freedom of conscience and conscientious objection by comparing the solemnization of same-sex marriage by public servants, with another public service: that of terminations of pregnancy. While each situation will inevitably turn on the particular circumstances of the case, I argue that there should be a content-neutral guiding principle (as well as consistency) in dealing with these situations. The issue in each situation is narrowed to whether a civil servant’s personal convictions can override the state’s secular obligations in providing a service, and whether there is room for a qualified right to conscientious objection. By analysing the matter in this way, it is clear that the unqualified statutory exemption clause in South Africa’s Civil Union Act is constitutionally objectionable.
- Full Text: false
- Date Issued: 2014
- Authors: Kruuse, Helen
- Date: 2014
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/129186 , vital:36228 , https://doi.org/10.1093/lawfam/ebu001
- Description: This article considers whether public servants should be exempt from South Africa’s equality provisions and anti-discrimination legislation in solemnizing same-sex marriages. In order to deal with this question, the article analyses the treatment of freedom of conscience and conscientious objection by comparing the solemnization of same-sex marriage by public servants, with another public service: that of terminations of pregnancy. While each situation will inevitably turn on the particular circumstances of the case, I argue that there should be a content-neutral guiding principle (as well as consistency) in dealing with these situations. The issue in each situation is narrowed to whether a civil servant’s personal convictions can override the state’s secular obligations in providing a service, and whether there is room for a qualified right to conscientious objection. By analysing the matter in this way, it is clear that the unqualified statutory exemption clause in South Africa’s Civil Union Act is constitutionally objectionable.
- Full Text: false
- Date Issued: 2014
A decade later: follow-up review of South African research on the consequences of and contributory factors in teen-aged pregnancy
- Macleod, Catriona I, Tracey, Tiffany
- Authors: Macleod, Catriona I , Tracey, Tiffany
- Date: 2010
- Language: English
- Type: Article
- Identifier: vital:6276 , http://hdl.handle.net/10962/d1008276 , http://journals.sagepub.com/doi/abs/10.1177/008124631004000103
- Description: In this paper, we review South African research conducted in the last 10 years on the consequences of and contributory factors in teen-aged pregnancy. We discuss research into the rates of teen-aged pregnancy, the intentionality and wantedness of pregnancy, the disruption of schooling, health issues, consequences for the children, welfare concerns, knowledge and use of contraception, timing of sexual debut, age of partner, coercive sexual relations, cultural factors and health service provision. We compare this discussion to the reviews on the same topic appearing in the South African Journal of Psychology a decade ago. We find that there are several changes in focus in the research on pregnancy amongst young women. We conclude that, in general, there has been an improvement in the breadth of data available, mostly as a result of representative national and local surveys. A better teasing out of nuances around particular issues and a grappling with theoretical issues are also evident in recent research.
- Full Text:
- Date Issued: 2010
- Authors: Macleod, Catriona I , Tracey, Tiffany
- Date: 2010
- Language: English
- Type: Article
- Identifier: vital:6276 , http://hdl.handle.net/10962/d1008276 , http://journals.sagepub.com/doi/abs/10.1177/008124631004000103
- Description: In this paper, we review South African research conducted in the last 10 years on the consequences of and contributory factors in teen-aged pregnancy. We discuss research into the rates of teen-aged pregnancy, the intentionality and wantedness of pregnancy, the disruption of schooling, health issues, consequences for the children, welfare concerns, knowledge and use of contraception, timing of sexual debut, age of partner, coercive sexual relations, cultural factors and health service provision. We compare this discussion to the reviews on the same topic appearing in the South African Journal of Psychology a decade ago. We find that there are several changes in focus in the research on pregnancy amongst young women. We conclude that, in general, there has been an improvement in the breadth of data available, mostly as a result of representative national and local surveys. A better teasing out of nuances around particular issues and a grappling with theoretical issues are also evident in recent research.
- Full Text:
- Date Issued: 2010
Psycho-medical discourse in South African research on teenage pregnancy
- Macleod, Catriona I, Durrheim, Kevin
- Authors: Macleod, Catriona I , Durrheim, Kevin
- Date: 2003
- Language: English
- Type: Article
- Identifier: vital:6257 , http://hdl.handle.net/10962/d1007875
- Description: Catriona Macleod and Kevin Durrheim apply a Foucauldian analysis to the scientific literature on teenage pregnancy.
- Full Text:
- Date Issued: 2003
- Authors: Macleod, Catriona I , Durrheim, Kevin
- Date: 2003
- Language: English
- Type: Article
- Identifier: vital:6257 , http://hdl.handle.net/10962/d1007875
- Description: Catriona Macleod and Kevin Durrheim apply a Foucauldian analysis to the scientific literature on teenage pregnancy.
- Full Text:
- Date Issued: 2003
Racializing teenage pregnancy : ‘culture’ and ‘tradition’ in the South African scientific literature
- Macleod, Catriona I, Durrheim, Kevin
- Authors: Macleod, Catriona I , Durrheim, Kevin
- Date: 2002
- Language: English
- Type: Article
- Identifier: vital:6260 , http://hdl.handle.net/10962/d1007878
- Description: The signifiers, ‘race’, ‘culture’ or ‘ethnicity’ are utilized in the teenage pregnancy literature (1) to highlight ‘differences’ in adolescent sexual and reproductive behaviour and (2) as explanatory tools. When ‘white’ teenagers are the focus of research, psychological explanations are usually invoked, while for ‘black’ teenagers, explanations are socio-cultural in nature. In this paper, we explore how, through a process of racialization, the psycho-medical literature on teenage pregnancy in South Africa contributes to the entrenchment of ‘race’, ‘culture’ and ‘ethnicity’ as fixed, ‘natural’ signifiers. We utilize Derrida’s notion of différance, together with Phoenix and Woollett’s adaptation – ‘normalized absence/pathologized presence’ – to indicate how ‘black’ people are cast as the Other, the pathologized presence which relies on the normalized absent trace, ‘whiteness’, for definition. We analyse how the notions of ‘tradition’ and ‘culture’ are deployed to sanitize or disguise the underlying racializing project. ‘Black’ is exoticized and rendered strange and thus open to scrutiny, monitoring and intervention. ‘Culture’ and ‘tradition’ appeal to the myth of origin, thus providing pseudo-historical explanations which essentialize and naturalize racialized collectivities. , Rhodes University
- Full Text:
- Date Issued: 2002
Racializing teenage pregnancy : ‘culture’ and ‘tradition’ in the South African scientific literature
- Authors: Macleod, Catriona I , Durrheim, Kevin
- Date: 2002
- Language: English
- Type: Article
- Identifier: vital:6260 , http://hdl.handle.net/10962/d1007878
- Description: The signifiers, ‘race’, ‘culture’ or ‘ethnicity’ are utilized in the teenage pregnancy literature (1) to highlight ‘differences’ in adolescent sexual and reproductive behaviour and (2) as explanatory tools. When ‘white’ teenagers are the focus of research, psychological explanations are usually invoked, while for ‘black’ teenagers, explanations are socio-cultural in nature. In this paper, we explore how, through a process of racialization, the psycho-medical literature on teenage pregnancy in South Africa contributes to the entrenchment of ‘race’, ‘culture’ and ‘ethnicity’ as fixed, ‘natural’ signifiers. We utilize Derrida’s notion of différance, together with Phoenix and Woollett’s adaptation – ‘normalized absence/pathologized presence’ – to indicate how ‘black’ people are cast as the Other, the pathologized presence which relies on the normalized absent trace, ‘whiteness’, for definition. We analyse how the notions of ‘tradition’ and ‘culture’ are deployed to sanitize or disguise the underlying racializing project. ‘Black’ is exoticized and rendered strange and thus open to scrutiny, monitoring and intervention. ‘Culture’ and ‘tradition’ appeal to the myth of origin, thus providing pseudo-historical explanations which essentialize and naturalize racialized collectivities. , Rhodes University
- Full Text:
- Date Issued: 2002
A hand to mouth existence: hurdles emanating from the COVID 19 Pandemic for Women Survivalist Entrepreneurs in Johannesburg, South Africa
- Mapuranga, Miston, Maziriri, Eugine Tafadzwa, Rukuni, Tarisai Fritz
- Authors: Mapuranga, Miston , Maziriri, Eugine Tafadzwa , Rukuni, Tarisai Fritz
- Date: 2021-09-13
- Subjects: Covid-19 (Disease) , Women-owned business enterprises , Entrepreneurship
- Language: English
- Type: article
- Identifier: http://hdl.handle.net/11260/7460 , vital:53960 , https://doi.org/10.31920/2634-3622/2021/v10n3a6
- Description: There are many women survivalist entrepreneurs in South Africa, many of whom work in the informal sector. The emergence of theCOVID-19 pandemic has a devastating effect on their entrepreneurial projects. While both the public and private sectors have initiated various measures to ease the blow, obstacles continue to confront them. This study sought to examine the challenges faced by women survivalist entrepreneurs in South Africa’s Johannesburg metropolitan area. The researchers gathered qualitative data using a qualitative research approach by conducting semi-structured face-to-face interviews. The data was analysed using thematic analyses. The themes that emerged from the findings include; a lack of capital for reinvestment, no government grant support, a decline in the demand for products by the market, rotting agricultural produce or stock, a battle for strategic selling points and numerous confrontations with police as a result of not meeting the regulatory rules relating to COVID-19. The present research provides theoretical implications for academics in entrepreneurship by enhancing the understanding of the hurdles that these entrepreneurs have experienced because of COVID-19. On the practitioners’ side, this work offers avenues for women survivalist entrepreneurs to improve their entrepreneurial ventures and eventually eliminate the challenges they face when running their ventures. This study also offers policy implications. For example, existing government policies can be amended to make the working conditions of women survivalist entrepreneurs better or make the rules under which they operate simpler. This study contributes to entrepreneurship literature by uncovering the difficulties faced by women survivalist entrepreneurs due to the COVID-19 pandemic. It will assist other scholars in further developing this research field. As such, this research is important for women survivalist entrepreneurs because most of them endeavour to enhance entrepreneurial performance for the betterment of their lives. Governments may also use the study to develop interventions aimed at facilitating the growth and development of women survivalist entrepreneurs.
- Full Text:
- Date Issued: 2021-09-13
- Authors: Mapuranga, Miston , Maziriri, Eugine Tafadzwa , Rukuni, Tarisai Fritz
- Date: 2021-09-13
- Subjects: Covid-19 (Disease) , Women-owned business enterprises , Entrepreneurship
- Language: English
- Type: article
- Identifier: http://hdl.handle.net/11260/7460 , vital:53960 , https://doi.org/10.31920/2634-3622/2021/v10n3a6
- Description: There are many women survivalist entrepreneurs in South Africa, many of whom work in the informal sector. The emergence of theCOVID-19 pandemic has a devastating effect on their entrepreneurial projects. While both the public and private sectors have initiated various measures to ease the blow, obstacles continue to confront them. This study sought to examine the challenges faced by women survivalist entrepreneurs in South Africa’s Johannesburg metropolitan area. The researchers gathered qualitative data using a qualitative research approach by conducting semi-structured face-to-face interviews. The data was analysed using thematic analyses. The themes that emerged from the findings include; a lack of capital for reinvestment, no government grant support, a decline in the demand for products by the market, rotting agricultural produce or stock, a battle for strategic selling points and numerous confrontations with police as a result of not meeting the regulatory rules relating to COVID-19. The present research provides theoretical implications for academics in entrepreneurship by enhancing the understanding of the hurdles that these entrepreneurs have experienced because of COVID-19. On the practitioners’ side, this work offers avenues for women survivalist entrepreneurs to improve their entrepreneurial ventures and eventually eliminate the challenges they face when running their ventures. This study also offers policy implications. For example, existing government policies can be amended to make the working conditions of women survivalist entrepreneurs better or make the rules under which they operate simpler. This study contributes to entrepreneurship literature by uncovering the difficulties faced by women survivalist entrepreneurs due to the COVID-19 pandemic. It will assist other scholars in further developing this research field. As such, this research is important for women survivalist entrepreneurs because most of them endeavour to enhance entrepreneurial performance for the betterment of their lives. Governments may also use the study to develop interventions aimed at facilitating the growth and development of women survivalist entrepreneurs.
- Full Text:
- Date Issued: 2021-09-13