Regional geochemistry of the Karoo igneous province
- Duncan, Andrew R, Erlank, Anthony J, Marsh, Julian S
- Authors: Duncan, Andrew R , Erlank, Anthony J , Marsh, Julian S
- Date: 1984
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/134154 , vital:37079 , https://inis.iaea.org/search/searchsinglerecord.aspx?recordsFor=SingleRecordamp;RN=15001076
- Description: The extrusive and intrusive rocks of the Karoo Igneous Province are dominantly of basaltic or rhyolitic (sensu lato) composition. There are, however, a considerable variety of other rock types within the province including picritic basalts, nephelinites, shoshonites, latites, andesites and dacites. This paper deals with the geochemistry of the Karoo igneous province.
- Full Text:
- Date Issued: 1984
- Authors: Duncan, Andrew R , Erlank, Anthony J , Marsh, Julian S
- Date: 1984
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/134154 , vital:37079 , https://inis.iaea.org/search/searchsinglerecord.aspx?recordsFor=SingleRecordamp;RN=15001076
- Description: The extrusive and intrusive rocks of the Karoo Igneous Province are dominantly of basaltic or rhyolitic (sensu lato) composition. There are, however, a considerable variety of other rock types within the province including picritic basalts, nephelinites, shoshonites, latites, andesites and dacites. This paper deals with the geochemistry of the Karoo igneous province.
- Full Text:
- Date Issued: 1984
More media for Southern Africa?: the place of politics, economics and convergence in developing media density
- Authors: Berger, Guy
- Date: 2007
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147825 , vital:38676 , https://0-doi.org.wam.seals.ac.za/10.1080/02560240485310041
- Description: In line with global trends, media in Southern Africa in the past decade has been moving slowly towards mergers, partnerships and multi-platform publishing. Driven by politics and facilitated by technology, the process has had to confront the difficulty of establishing viable economic models, the lack of regional integration within Southern African countries, and what is sometimes a difficult political environment. Markets remain largely national or local and economically weak. Print media faces huge hurdles. Broadcast media density is improving, partly through noncommercial mechanisms. News websites are understaffed, lacking in viable survival strategies and skills, and are incompletely integrated with parent media platforms. Economic pressures, however, are likely to force Southern African media operations into greater synergies in search of survival. The various convergences entailed may increase media density.
- Full Text:
- Date Issued: 2007
- Authors: Berger, Guy
- Date: 2007
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147825 , vital:38676 , https://0-doi.org.wam.seals.ac.za/10.1080/02560240485310041
- Description: In line with global trends, media in Southern Africa in the past decade has been moving slowly towards mergers, partnerships and multi-platform publishing. Driven by politics and facilitated by technology, the process has had to confront the difficulty of establishing viable economic models, the lack of regional integration within Southern African countries, and what is sometimes a difficult political environment. Markets remain largely national or local and economically weak. Print media faces huge hurdles. Broadcast media density is improving, partly through noncommercial mechanisms. News websites are understaffed, lacking in viable survival strategies and skills, and are incompletely integrated with parent media platforms. Economic pressures, however, are likely to force Southern African media operations into greater synergies in search of survival. The various convergences entailed may increase media density.
- Full Text:
- Date Issued: 2007
Identification of Selective Novel Hits against Plasmodium falciparum Prolyl tRNA Synthetase Active Site and a Predicted Allosteric Site Using in silico Approaches:
- Nyamai, Dorothy Wavinya, Tastan Bishop, Özlem
- Authors: Nyamai, Dorothy Wavinya , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149229 , vital:38817 , https://doi.org/10.3390/ijms21113803
- Description: Recently, there has been increased interest in aminoacyl tRNA synthetases (aaRSs) as potential malarial drug targets. These enzymes play a key role in protein translation by the addition of amino acids to their cognate tRNA. The aaRSs are present in all Plasmodium life cycle stages, and thus present an attractive malarial drug target. Prolyl tRNA synthetase is a class II aaRS that functions in charging tRNA with proline. Various inhibitors against Plasmodium falciparum ProRS (PfProRS) active site have been designed. However, none have gone through clinical trials as they have been found to be highly toxic to human cells. Recently, a possible allosteric site was reported in PfProRS with two possible allosteric modulators: glyburide and TCMDC-124506. In this study, we sought to identify novel selective inhibitors targeting PfProRS active site and possible novel allosteric modulators of this enzyme. To achieve this, virtual screening of South African natural compounds against PfProRS and the human homologue was carried out using AutoDock Vina. The modulation of protein motions by ligand binding was studied by molecular dynamics (MD) using the GROningen MAchine for Chemical Simulations (GROMACS) tool. To further analyse the protein global motions and energetic changes upon ligand binding, principal component analysis (PCA), and free energy landscape (FEL) calculations were performed.
- Full Text:
- Date Issued: 2020
- Authors: Nyamai, Dorothy Wavinya , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149229 , vital:38817 , https://doi.org/10.3390/ijms21113803
- Description: Recently, there has been increased interest in aminoacyl tRNA synthetases (aaRSs) as potential malarial drug targets. These enzymes play a key role in protein translation by the addition of amino acids to their cognate tRNA. The aaRSs are present in all Plasmodium life cycle stages, and thus present an attractive malarial drug target. Prolyl tRNA synthetase is a class II aaRS that functions in charging tRNA with proline. Various inhibitors against Plasmodium falciparum ProRS (PfProRS) active site have been designed. However, none have gone through clinical trials as they have been found to be highly toxic to human cells. Recently, a possible allosteric site was reported in PfProRS with two possible allosteric modulators: glyburide and TCMDC-124506. In this study, we sought to identify novel selective inhibitors targeting PfProRS active site and possible novel allosteric modulators of this enzyme. To achieve this, virtual screening of South African natural compounds against PfProRS and the human homologue was carried out using AutoDock Vina. The modulation of protein motions by ligand binding was studied by molecular dynamics (MD) using the GROningen MAchine for Chemical Simulations (GROMACS) tool. To further analyse the protein global motions and energetic changes upon ligand binding, principal component analysis (PCA), and free energy landscape (FEL) calculations were performed.
- Full Text:
- Date Issued: 2020
Equality and unfair discrimination: refining the Harksen test
- Authors: Krüger, Rósaan
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68890 , vital:29336 , https://hdl.handle.net/10520/EJC53981
- Description: Publisher version , The 1997 formulation of the test in Harksen by Constitutional Court seemed to settle the constitutional standards in respect of equality and unfair discrimination. In this article this test is scrutinised closely with a view to clarify the different aspects of the right protected in s 9. Reliance is further placed on Canadian commentary which interrogates the dignity-centred analysis of the Canadian Supreme Court in relation to the Canadian Charter's prohibition of discrimination. The similar insistence on dignity as the interest protected by the right to equality opens up new possibilities in the South African context. Accordingly, specific 'wrongs' or 'indignities' of inequality are identified, which refines the Harksen test. The identification of the indignities, it is suggested, assists litigants and the court on a practical level when determining the fairness or otherwise of discrimination.
- Full Text: false
- Date Issued: 2011
- Authors: Krüger, Rósaan
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68890 , vital:29336 , https://hdl.handle.net/10520/EJC53981
- Description: Publisher version , The 1997 formulation of the test in Harksen by Constitutional Court seemed to settle the constitutional standards in respect of equality and unfair discrimination. In this article this test is scrutinised closely with a view to clarify the different aspects of the right protected in s 9. Reliance is further placed on Canadian commentary which interrogates the dignity-centred analysis of the Canadian Supreme Court in relation to the Canadian Charter's prohibition of discrimination. The similar insistence on dignity as the interest protected by the right to equality opens up new possibilities in the South African context. Accordingly, specific 'wrongs' or 'indignities' of inequality are identified, which refines the Harksen test. The identification of the indignities, it is suggested, assists litigants and the court on a practical level when determining the fairness or otherwise of discrimination.
- Full Text: false
- Date Issued: 2011
The narrative of vulnerability and deprivation in protection regimes for the internally displaced persons (IDPs) in Africa: an appraisal of the Kampala Convention
- Authors: Juma, Laurence
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/128448 , vital:36110 , https://heinonline.org/HOL/Page?handle=hein.journals/laacydev16amp;div=14amp;g_sent=1amp;casa_token=amp;collection=journals
- Description: Prior to the 1990s, the phenomenon of internal displacement did not attract much attention from the international community. Most states, suspicious of the external interests in what they considered to be a purely internal matter were not keen to expose difficulties or suffering of their displaced citizens. And insistence on protection of the internally displaced by international organisations was seen as an affront to sovereignty.
- Full Text: false
- Date Issued: 2012
- Authors: Juma, Laurence
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/128448 , vital:36110 , https://heinonline.org/HOL/Page?handle=hein.journals/laacydev16amp;div=14amp;g_sent=1amp;casa_token=amp;collection=journals
- Description: Prior to the 1990s, the phenomenon of internal displacement did not attract much attention from the international community. Most states, suspicious of the external interests in what they considered to be a purely internal matter were not keen to expose difficulties or suffering of their displaced citizens. And insistence on protection of the internally displaced by international organisations was seen as an affront to sovereignty.
- Full Text: false
- Date Issued: 2012
- «
- ‹
- 1
- ›
- »