Identification of Selective Novel Hits against Plasmodium falciparum Prolyl tRNA Synthetase Active Site and a Predicted Allosteric Site Using in silico Approaches:
- Nyamai, Dorothy Wavinya, Tastan Bishop, Özlem
- Authors: Nyamai, Dorothy Wavinya , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149229 , vital:38817 , https://doi.org/10.3390/ijms21113803
- Description: Recently, there has been increased interest in aminoacyl tRNA synthetases (aaRSs) as potential malarial drug targets. These enzymes play a key role in protein translation by the addition of amino acids to their cognate tRNA. The aaRSs are present in all Plasmodium life cycle stages, and thus present an attractive malarial drug target. Prolyl tRNA synthetase is a class II aaRS that functions in charging tRNA with proline. Various inhibitors against Plasmodium falciparum ProRS (PfProRS) active site have been designed. However, none have gone through clinical trials as they have been found to be highly toxic to human cells. Recently, a possible allosteric site was reported in PfProRS with two possible allosteric modulators: glyburide and TCMDC-124506. In this study, we sought to identify novel selective inhibitors targeting PfProRS active site and possible novel allosteric modulators of this enzyme. To achieve this, virtual screening of South African natural compounds against PfProRS and the human homologue was carried out using AutoDock Vina. The modulation of protein motions by ligand binding was studied by molecular dynamics (MD) using the GROningen MAchine for Chemical Simulations (GROMACS) tool. To further analyse the protein global motions and energetic changes upon ligand binding, principal component analysis (PCA), and free energy landscape (FEL) calculations were performed.
- Full Text:
- Date Issued: 2020
- Authors: Nyamai, Dorothy Wavinya , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/149229 , vital:38817 , https://doi.org/10.3390/ijms21113803
- Description: Recently, there has been increased interest in aminoacyl tRNA synthetases (aaRSs) as potential malarial drug targets. These enzymes play a key role in protein translation by the addition of amino acids to their cognate tRNA. The aaRSs are present in all Plasmodium life cycle stages, and thus present an attractive malarial drug target. Prolyl tRNA synthetase is a class II aaRS that functions in charging tRNA with proline. Various inhibitors against Plasmodium falciparum ProRS (PfProRS) active site have been designed. However, none have gone through clinical trials as they have been found to be highly toxic to human cells. Recently, a possible allosteric site was reported in PfProRS with two possible allosteric modulators: glyburide and TCMDC-124506. In this study, we sought to identify novel selective inhibitors targeting PfProRS active site and possible novel allosteric modulators of this enzyme. To achieve this, virtual screening of South African natural compounds against PfProRS and the human homologue was carried out using AutoDock Vina. The modulation of protein motions by ligand binding was studied by molecular dynamics (MD) using the GROningen MAchine for Chemical Simulations (GROMACS) tool. To further analyse the protein global motions and energetic changes upon ligand binding, principal component analysis (PCA), and free energy landscape (FEL) calculations were performed.
- Full Text:
- Date Issued: 2020
Gender Policy: discussion document 27-29 March 2012
- Congress of South African Trade Unions (COSATU)
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Uncatalogued
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68759 , vital:29312
- Description: The Gender policy draws together existing COSATU resolutions into a coherent document, while further enriching these resolutions. This document aims to combine the vision and principles that we aspire towards, with practical relations in the working workplace and economy, in trade unions and in broader society. The issue of gender equality has been on our agenda since the formation of COSATU. However, we require a policy framework to guide our struggles to transform gender relations in the current period. It is therefore important that we reflect on progress in taking forward the vision and programmes adopted on several Congresses since COSATU inception. In broad terms, progress to realise these resolutions has been uneven and varies between affiliates. COSATU and its affiliates are guided by a vision of a society free of sexism, racism, class exploitation, and other forms of oppression. We envisage a future where women participate equally in the economy and society without barriers, and where women are emancipated from all forms of oppression in the household, the workplace and in broader society. We have a vision of a trade union movement as a home for women workers. This policy document was debated and adopted and the National Gender Conference (held on 5-7 July 2000). It is tabled at Congress for discussion and adoption. Once it has been adopted by the Congress all affiliates will have to give expression to this broad framework in their own policies.
- Full Text:
- Date Issued: 2012
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Uncatalogued
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68759 , vital:29312
- Description: The Gender policy draws together existing COSATU resolutions into a coherent document, while further enriching these resolutions. This document aims to combine the vision and principles that we aspire towards, with practical relations in the working workplace and economy, in trade unions and in broader society. The issue of gender equality has been on our agenda since the formation of COSATU. However, we require a policy framework to guide our struggles to transform gender relations in the current period. It is therefore important that we reflect on progress in taking forward the vision and programmes adopted on several Congresses since COSATU inception. In broad terms, progress to realise these resolutions has been uneven and varies between affiliates. COSATU and its affiliates are guided by a vision of a society free of sexism, racism, class exploitation, and other forms of oppression. We envisage a future where women participate equally in the economy and society without barriers, and where women are emancipated from all forms of oppression in the household, the workplace and in broader society. We have a vision of a trade union movement as a home for women workers. This policy document was debated and adopted and the National Gender Conference (held on 5-7 July 2000). It is tabled at Congress for discussion and adoption. Once it has been adopted by the Congress all affiliates will have to give expression to this broad framework in their own policies.
- Full Text:
- Date Issued: 2012
The narrative of vulnerability and deprivation in protection regimes for the internally displaced persons (IDPs) in Africa: an appraisal of the Kampala Convention
- Authors: Juma, Laurence
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/128448 , vital:36110 , https://heinonline.org/HOL/Page?handle=hein.journals/laacydev16amp;div=14amp;g_sent=1amp;casa_token=amp;collection=journals
- Description: Prior to the 1990s, the phenomenon of internal displacement did not attract much attention from the international community. Most states, suspicious of the external interests in what they considered to be a purely internal matter were not keen to expose difficulties or suffering of their displaced citizens. And insistence on protection of the internally displaced by international organisations was seen as an affront to sovereignty.
- Full Text: false
- Date Issued: 2012
- Authors: Juma, Laurence
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/128448 , vital:36110 , https://heinonline.org/HOL/Page?handle=hein.journals/laacydev16amp;div=14amp;g_sent=1amp;casa_token=amp;collection=journals
- Description: Prior to the 1990s, the phenomenon of internal displacement did not attract much attention from the international community. Most states, suspicious of the external interests in what they considered to be a purely internal matter were not keen to expose difficulties or suffering of their displaced citizens. And insistence on protection of the internally displaced by international organisations was seen as an affront to sovereignty.
- Full Text: false
- Date Issued: 2012
Equality and unfair discrimination: refining the Harksen test
- Authors: Krüger, Rósaan
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68890 , vital:29336 , https://hdl.handle.net/10520/EJC53981
- Description: Publisher version , The 1997 formulation of the test in Harksen by Constitutional Court seemed to settle the constitutional standards in respect of equality and unfair discrimination. In this article this test is scrutinised closely with a view to clarify the different aspects of the right protected in s 9. Reliance is further placed on Canadian commentary which interrogates the dignity-centred analysis of the Canadian Supreme Court in relation to the Canadian Charter's prohibition of discrimination. The similar insistence on dignity as the interest protected by the right to equality opens up new possibilities in the South African context. Accordingly, specific 'wrongs' or 'indignities' of inequality are identified, which refines the Harksen test. The identification of the indignities, it is suggested, assists litigants and the court on a practical level when determining the fairness or otherwise of discrimination.
- Full Text: false
- Date Issued: 2011
- Authors: Krüger, Rósaan
- Date: 2011
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/68890 , vital:29336 , https://hdl.handle.net/10520/EJC53981
- Description: Publisher version , The 1997 formulation of the test in Harksen by Constitutional Court seemed to settle the constitutional standards in respect of equality and unfair discrimination. In this article this test is scrutinised closely with a view to clarify the different aspects of the right protected in s 9. Reliance is further placed on Canadian commentary which interrogates the dignity-centred analysis of the Canadian Supreme Court in relation to the Canadian Charter's prohibition of discrimination. The similar insistence on dignity as the interest protected by the right to equality opens up new possibilities in the South African context. Accordingly, specific 'wrongs' or 'indignities' of inequality are identified, which refines the Harksen test. The identification of the indignities, it is suggested, assists litigants and the court on a practical level when determining the fairness or otherwise of discrimination.
- Full Text: false
- Date Issued: 2011
Penology, Victimology & Crime Prevention: CRM 122
- Authors: Earl-Taylor, M , Daniel, N
- Date: 2010-11
- Language: English
- Type: Examination paper
- Identifier: vital:18219 , http://hdl.handle.net/10353/d1011210
- Description: Penology, Victimology & Crime Prevention: CRM 122, degree examination November 2010.
- Full Text: false
- Date Issued: 2010-11
- Authors: Earl-Taylor, M , Daniel, N
- Date: 2010-11
- Language: English
- Type: Examination paper
- Identifier: vital:18219 , http://hdl.handle.net/10353/d1011210
- Description: Penology, Victimology & Crime Prevention: CRM 122, degree examination November 2010.
- Full Text: false
- Date Issued: 2010-11
More media for Southern Africa?: the place of politics, economics and convergence in developing media density
- Authors: Berger, Guy
- Date: 2007
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147825 , vital:38676 , https://0-doi.org.wam.seals.ac.za/10.1080/02560240485310041
- Description: In line with global trends, media in Southern Africa in the past decade has been moving slowly towards mergers, partnerships and multi-platform publishing. Driven by politics and facilitated by technology, the process has had to confront the difficulty of establishing viable economic models, the lack of regional integration within Southern African countries, and what is sometimes a difficult political environment. Markets remain largely national or local and economically weak. Print media faces huge hurdles. Broadcast media density is improving, partly through noncommercial mechanisms. News websites are understaffed, lacking in viable survival strategies and skills, and are incompletely integrated with parent media platforms. Economic pressures, however, are likely to force Southern African media operations into greater synergies in search of survival. The various convergences entailed may increase media density.
- Full Text:
- Date Issued: 2007
- Authors: Berger, Guy
- Date: 2007
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/147825 , vital:38676 , https://0-doi.org.wam.seals.ac.za/10.1080/02560240485310041
- Description: In line with global trends, media in Southern Africa in the past decade has been moving slowly towards mergers, partnerships and multi-platform publishing. Driven by politics and facilitated by technology, the process has had to confront the difficulty of establishing viable economic models, the lack of regional integration within Southern African countries, and what is sometimes a difficult political environment. Markets remain largely national or local and economically weak. Print media faces huge hurdles. Broadcast media density is improving, partly through noncommercial mechanisms. News websites are understaffed, lacking in viable survival strategies and skills, and are incompletely integrated with parent media platforms. Economic pressures, however, are likely to force Southern African media operations into greater synergies in search of survival. The various convergences entailed may increase media density.
- Full Text:
- Date Issued: 2007
SACCAWU - NSSC Treasurer’s Report & NSSC Finances
- SACCAWU
- Authors: SACCAWU
- Date: Oct 2007
- Subjects: SACCAWU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/113891 , vital:33842
- Description: Comrades, this historical 3rd National Summit is convened at a time when the National Democratic Revolution is under attack left, right and centre. We have recently held an ANC Policy Conference; SACP National Congress and COSATU Central Committee, as well as SACCAWU National Bargaining Conference. These Alliance meetings took a number of resolutions for implementation. One has observed a very sorry state of affairs in that some shopstewards who are seen to be very prominent in Shoprite meetings, do not attend SACCAWU structures, let alone COSATU, ANC & SACP structures. This Summit will have to discuss on how we are to revive structures at Shoprite and participation in the aforementioned structures. For the record, it will prudent for one to bring to the notice of the Summit that to date, we have concluded a hand-over of which I will elaborate under NFC in this Report.
- Full Text:
- Date Issued: Oct 2007
- Authors: SACCAWU
- Date: Oct 2007
- Subjects: SACCAWU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/113891 , vital:33842
- Description: Comrades, this historical 3rd National Summit is convened at a time when the National Democratic Revolution is under attack left, right and centre. We have recently held an ANC Policy Conference; SACP National Congress and COSATU Central Committee, as well as SACCAWU National Bargaining Conference. These Alliance meetings took a number of resolutions for implementation. One has observed a very sorry state of affairs in that some shopstewards who are seen to be very prominent in Shoprite meetings, do not attend SACCAWU structures, let alone COSATU, ANC & SACP structures. This Summit will have to discuss on how we are to revive structures at Shoprite and participation in the aforementioned structures. For the record, it will prudent for one to bring to the notice of the Summit that to date, we have concluded a hand-over of which I will elaborate under NFC in this Report.
- Full Text:
- Date Issued: Oct 2007
Attitudes of Xhosa-speaking students at the University of Fort Hare towards the use of Xhosa as a language of learning and teaching (LOLT)
- Dalvit, Lorenzo, De Klerk, Vivian A
- Authors: Dalvit, Lorenzo , De Klerk, Vivian A
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6100 , http://hdl.handle.net/10962/d1008664
- Description: This article presents and discusses the results of a survey of a sample of Xhosa-speaking students at the University of Fort Hare regarding their attitudes towards the possible introduction of Xhosa as a medium of instruction at this institution. The research takes into account, among other things, the students' attitudes towards English and Xhosa and their opinions and beliefs about the introduction of dual-mediumship and its possible consequences. The survey was conducted with questionnaires and interviews and the results were first analysed as a whole, and then split into different categories according to gender, year of study, subject studied etc. This analysis indicates that while English is recognised as the dominant language in South Africa and, more specifically, in the domain of education, some categories of respondents acknowledge the usefulness of Xhosa as an additional medium of instruction. This survey clearly shows that it would make little sense to present Xhosa-speaking students at Fort Hare with a rigid choice between the existing English-medium and a dual-medium (English and Xhosa) policy and that more nuanced options would need to be offered. For example, respondents seem to consider the use of Xhosa as a medium of instruction more appropriate in the first years of study, for selected subjects and in some domains within the academic context rather than others. This study can be fruitfully compared with similar research carried out at other South African institutions. Moreover, the results of the present research can be used to inform future decisions regarding language policy at the University of Fort Hare.
- Full Text:
- Date Issued: 2005
- Authors: Dalvit, Lorenzo , De Klerk, Vivian A
- Date: 2005
- Language: English
- Type: Article
- Identifier: vital:6100 , http://hdl.handle.net/10962/d1008664
- Description: This article presents and discusses the results of a survey of a sample of Xhosa-speaking students at the University of Fort Hare regarding their attitudes towards the possible introduction of Xhosa as a medium of instruction at this institution. The research takes into account, among other things, the students' attitudes towards English and Xhosa and their opinions and beliefs about the introduction of dual-mediumship and its possible consequences. The survey was conducted with questionnaires and interviews and the results were first analysed as a whole, and then split into different categories according to gender, year of study, subject studied etc. This analysis indicates that while English is recognised as the dominant language in South Africa and, more specifically, in the domain of education, some categories of respondents acknowledge the usefulness of Xhosa as an additional medium of instruction. This survey clearly shows that it would make little sense to present Xhosa-speaking students at Fort Hare with a rigid choice between the existing English-medium and a dual-medium (English and Xhosa) policy and that more nuanced options would need to be offered. For example, respondents seem to consider the use of Xhosa as a medium of instruction more appropriate in the first years of study, for selected subjects and in some domains within the academic context rather than others. This study can be fruitfully compared with similar research carried out at other South African institutions. Moreover, the results of the present research can be used to inform future decisions regarding language policy at the University of Fort Hare.
- Full Text:
- Date Issued: 2005
Draft Gender Indicators
- COSATU
- Authors: COSATU
- Date: 2005
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/172109 , vital:42160
- Description: Women in both the trade union movement and the formal work environment face obstacles which inhibit the progress of their concerns. Despite a range of gender resolutions passed at trade union congresses and the equality clauses inherent in the constitution and labour legislation, issues of particular concern to women are not mainstreamed in trade union negotiations. In instances where issues such as maternity benefits are fully integrated, women workers may still face difficult choices when it comes to ensuring that rights and labour laws are adhered to in the workplace. Many women workers often find that their position at work has been changed while they have been off on maternity leave, or they have been included in a retrenchment negotiation while away. An important question to ask in building a framework of gender indicators for collective bargaining, are what are the obstacles in trade unions which inhibit women’s active participation in collective bargaining?
- Full Text:
- Date Issued: 2005
- Authors: COSATU
- Date: 2005
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/172109 , vital:42160
- Description: Women in both the trade union movement and the formal work environment face obstacles which inhibit the progress of their concerns. Despite a range of gender resolutions passed at trade union congresses and the equality clauses inherent in the constitution and labour legislation, issues of particular concern to women are not mainstreamed in trade union negotiations. In instances where issues such as maternity benefits are fully integrated, women workers may still face difficult choices when it comes to ensuring that rights and labour laws are adhered to in the workplace. Many women workers often find that their position at work has been changed while they have been off on maternity leave, or they have been included in a retrenchment negotiation while away. An important question to ask in building a framework of gender indicators for collective bargaining, are what are the obstacles in trade unions which inhibit women’s active participation in collective bargaining?
- Full Text:
- Date Issued: 2005
Holding on or letting go?: the resolution of grief in relation to two Xhosa rituals in South Africa
- Authors: Van Heerden, Gary Paul
- Date: 2003
- Subjects: South Africa -- Social life and customs , Death -- Social aspects -- South Africa , Mourning customs -- South Africa , Bereavement -- Psychological aspects , Bereavement -- South Africa -- Cross-cultural studies , Death -- South Africa -- Cross-cultural studies , Xhosa (African people) -- Rites and ceremonies , Xhosa (African people) -- Social life and customs , Animal sacrifice -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3253 , http://hdl.handle.net/10962/d1016055
- Description: The dominant emphasis in Western models of bereavement is on the breaking of bonds with the deceased in order for healing to occur. Failure to let go often leads to a diagnosis of 'pathological grief'. This paper challenges the assumption that death invariably means that the bonds with the deceased have to be severed. Situating Western models of bereavement in a modernist context not only challenges the 'truth' claims of these models, but also facilitates a deconstruction of the elements that contribute to the emphasis on letting go. In contrast to these theories, two Xhosa rituals (umkhapho and umbuyiso) that seek to sustain the bond with the deceased person will be examined. Such rituals demonstrate that it is possible to both maintain the bond and for the bereaved person to move on with their lives. Despite different contexts, it will be argued that these Xhosa bereavement rituals have a contribution to make to Western models of bereavement and some implications for therapy will be explored.
- Full Text:
- Date Issued: 2003
- Authors: Van Heerden, Gary Paul
- Date: 2003
- Subjects: South Africa -- Social life and customs , Death -- Social aspects -- South Africa , Mourning customs -- South Africa , Bereavement -- Psychological aspects , Bereavement -- South Africa -- Cross-cultural studies , Death -- South Africa -- Cross-cultural studies , Xhosa (African people) -- Rites and ceremonies , Xhosa (African people) -- Social life and customs , Animal sacrifice -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3253 , http://hdl.handle.net/10962/d1016055
- Description: The dominant emphasis in Western models of bereavement is on the breaking of bonds with the deceased in order for healing to occur. Failure to let go often leads to a diagnosis of 'pathological grief'. This paper challenges the assumption that death invariably means that the bonds with the deceased have to be severed. Situating Western models of bereavement in a modernist context not only challenges the 'truth' claims of these models, but also facilitates a deconstruction of the elements that contribute to the emphasis on letting go. In contrast to these theories, two Xhosa rituals (umkhapho and umbuyiso) that seek to sustain the bond with the deceased person will be examined. Such rituals demonstrate that it is possible to both maintain the bond and for the bereaved person to move on with their lives. Despite different contexts, it will be argued that these Xhosa bereavement rituals have a contribution to make to Western models of bereavement and some implications for therapy will be explored.
- Full Text:
- Date Issued: 2003
Foundation Course in Economics For Trade Unionists
- Authors: Trade Unionists
- Date: Mar 1998
- Subjects: Trade Unionists
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/138657 , vital:37660
- Description: To help participants develop a basic understanding of key economic concepts. To help participants to begin to apply these concepts to analyse current economic policy debates. To develop participants’ confidence and encourage them to pursue on going learning in economic analysis.
- Full Text:
- Date Issued: Mar 1998
- Authors: Trade Unionists
- Date: Mar 1998
- Subjects: Trade Unionists
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/138657 , vital:37660
- Description: To help participants develop a basic understanding of key economic concepts. To help participants to begin to apply these concepts to analyse current economic policy debates. To develop participants’ confidence and encourage them to pursue on going learning in economic analysis.
- Full Text:
- Date Issued: Mar 1998
Application for RDP funds in terms of the “extension of municipal services presidential lead programme’’ as programme managed by the Department of Constitutional Affairs
- Authors: Local RDP Committee
- Date: 1995-03-09
- Subjects: Reconstruction and Development Programme (South Africa) , Social service -- South Africa , Municipal services -- South Africa
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66131 , vital:28906
- Description: The majority of the residents of Khutsong are employed at mines in the area south of Carletonville (stretching form East Driefontein in the east to Deelkraal in the west), as well as in Carletonville itself. The large majority of these people are dependant on public transport for commuting to work, for undertaking trips for shopping purposes and for going to school. The condition of the road network in Khutsong is of such a nature that large areas are totally inaccessible to public transport (especially in the rainy season) resulting in a situation where large numbers of people have to walk unacceptable long distances between their places of residence and public transport routes. A comprehensive programme have been embarked upon in consultation with the community to rectify this situation.
- Full Text:
- Date Issued: 1995-03-09
- Authors: Local RDP Committee
- Date: 1995-03-09
- Subjects: Reconstruction and Development Programme (South Africa) , Social service -- South Africa , Municipal services -- South Africa
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/66131 , vital:28906
- Description: The majority of the residents of Khutsong are employed at mines in the area south of Carletonville (stretching form East Driefontein in the east to Deelkraal in the west), as well as in Carletonville itself. The large majority of these people are dependant on public transport for commuting to work, for undertaking trips for shopping purposes and for going to school. The condition of the road network in Khutsong is of such a nature that large areas are totally inaccessible to public transport (especially in the rainy season) resulting in a situation where large numbers of people have to walk unacceptable long distances between their places of residence and public transport routes. A comprehensive programme have been embarked upon in consultation with the community to rectify this situation.
- Full Text:
- Date Issued: 1995-03-09
A basic guide to the Reconstruction and Development Programme
- Authors: African National Congress
- Date: 1994
- Subjects: Reconstruction and development programme (South Africa) , South Africa -- Economic policy , South Africa -- Social policy , African National Congress
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/75927 , vital:30483 , 1874902062
- Description: The RDP is a plan to address the many social and economic problems facing our country — problems such as...violence, lack of housing, lack of jobs, inadequate education and health care, lack of democracy, a failing economy. The RDP recognises that all of these problems are connected. For example, we cannot successfully build the economy while millions do not have homes or jobs. And we cannot provide homes and jobs without rebuilding the economy. We need policies and strategies to address all of the problems together. The RDP aims to do this. The RDP is a programme to mobilise all our people and all our resources to finally get rid of apartheid and build a democratic, non racial and non sexist future. The RDP was drawn up by the ANC-led alliance in consultation with other key mass organisations and assisted by a wide range of nongovernmental organisations (NGOs) and research organisations. This inclusive approach to developing and implementing policy — involving as many organisations as possible — is unique in South Africa’s political history. The ANC — because it is a liberation movement and based on the traditions of the Freedom Charter — is the only political organisation which can bring together such a wide range of social movements, community-based organisations and numerous other sectors and formations. This widespread and broad-based support throughout South Africa will allow the ANC within a Government of National Unity successfully to implement the RDP.
- Full Text:
- Date Issued: 1994
- Authors: African National Congress
- Date: 1994
- Subjects: Reconstruction and development programme (South Africa) , South Africa -- Economic policy , South Africa -- Social policy , African National Congress
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/75927 , vital:30483 , 1874902062
- Description: The RDP is a plan to address the many social and economic problems facing our country — problems such as...violence, lack of housing, lack of jobs, inadequate education and health care, lack of democracy, a failing economy. The RDP recognises that all of these problems are connected. For example, we cannot successfully build the economy while millions do not have homes or jobs. And we cannot provide homes and jobs without rebuilding the economy. We need policies and strategies to address all of the problems together. The RDP aims to do this. The RDP is a programme to mobilise all our people and all our resources to finally get rid of apartheid and build a democratic, non racial and non sexist future. The RDP was drawn up by the ANC-led alliance in consultation with other key mass organisations and assisted by a wide range of nongovernmental organisations (NGOs) and research organisations. This inclusive approach to developing and implementing policy — involving as many organisations as possible — is unique in South Africa’s political history. The ANC — because it is a liberation movement and based on the traditions of the Freedom Charter — is the only political organisation which can bring together such a wide range of social movements, community-based organisations and numerous other sectors and formations. This widespread and broad-based support throughout South Africa will allow the ANC within a Government of National Unity successfully to implement the RDP.
- Full Text:
- Date Issued: 1994
APDUSA Views
- Date: 1993-02
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/33013 , vital:32490 , Bulk File 7
- Description: APDUSA Views was published by the African People’s Democratic Union of Southern Africa (Natal), an affiliate of the New Unity Movement.
- Full Text: false
- Date Issued: 1993-02
- Date: 1993-02
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/33013 , vital:32490 , Bulk File 7
- Description: APDUSA Views was published by the African People’s Democratic Union of Southern Africa (Natal), an affiliate of the New Unity Movement.
- Full Text: false
- Date Issued: 1993-02
Up Beat Issue Number 5 1990
- SACHED
- Authors: SACHED
- Date: 1990
- Subjects: SACHED
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/118946 , vital:34685
- Description: Mbulelois 14 and Adelaide is 12. They live in Pabaleilo, a township outside Upington. They have not seen their mother, Evelina de Bruyn, for more than a year. They would love to see her. But they can’t. She is far away in a jail in Pretoria, waiting to die. Evelina was one of the accused in the Upington 25 murdertrial. In May 1989, Evelina, her husband Gideon Madlongolwane and 11 other people from Pabaleilo were sentenced to death for the ‘common purpose murder’ of Lucas Sethwala, a policeman. The judge said that Evelina de Bruyn did not actually take part in the physical attack on Lucas Setwala. B ut she was part of the crowd that marched on to the policeman’s house and killed him. The crowd had a ‘common purpose’, and that was to kill the policeman. And so Evelina was sentenced to death. Many people think that the idea of a common purpose is wrong. Father Mkhatswa of the Human Rights Commission told Upbeat that people criticise this law because it is so serious. ‘In mass funerals or meetings thousands of people come together. When violence starts you can’t say that people planned the action. People are angry and upset. Also, how do you decide who was involved? Everyone present cannot be responsible.’
- Full Text:
- Date Issued: 1990
- Authors: SACHED
- Date: 1990
- Subjects: SACHED
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/118946 , vital:34685
- Description: Mbulelois 14 and Adelaide is 12. They live in Pabaleilo, a township outside Upington. They have not seen their mother, Evelina de Bruyn, for more than a year. They would love to see her. But they can’t. She is far away in a jail in Pretoria, waiting to die. Evelina was one of the accused in the Upington 25 murdertrial. In May 1989, Evelina, her husband Gideon Madlongolwane and 11 other people from Pabaleilo were sentenced to death for the ‘common purpose murder’ of Lucas Sethwala, a policeman. The judge said that Evelina de Bruyn did not actually take part in the physical attack on Lucas Setwala. B ut she was part of the crowd that marched on to the policeman’s house and killed him. The crowd had a ‘common purpose’, and that was to kill the policeman. And so Evelina was sentenced to death. Many people think that the idea of a common purpose is wrong. Father Mkhatswa of the Human Rights Commission told Upbeat that people criticise this law because it is so serious. ‘In mass funerals or meetings thousands of people come together. When violence starts you can’t say that people planned the action. People are angry and upset. Also, how do you decide who was involved? Everyone present cannot be responsible.’
- Full Text:
- Date Issued: 1990
English in Africa 2000 : towards a new millennium : inaugural lecture delivered at Rhodes University
- Authors: Walters, Paul S
- Date: 1988
- Subjects: Molteno Project , English language -- Study and teaching -- South Africa , English language -- Usage -- South Africa
- Language: English
- Type: Text
- Identifier: vital:678 , http://hdl.handle.net/10962/d1020747 , ISBN 0868101680
- Description: Inaugural lecture delivered at Rhodes University , Rhodes University Libraries (Digitisation)
- Full Text:
- Date Issued: 1988
English in Africa 2000 : towards a new millennium : inaugural lecture delivered at Rhodes University
- Authors: Walters, Paul S
- Date: 1988
- Subjects: Molteno Project , English language -- Study and teaching -- South Africa , English language -- Usage -- South Africa
- Language: English
- Type: Text
- Identifier: vital:678 , http://hdl.handle.net/10962/d1020747 , ISBN 0868101680
- Description: Inaugural lecture delivered at Rhodes University , Rhodes University Libraries (Digitisation)
- Full Text:
- Date Issued: 1988
COSATU constitution as amended at COSATU 2nd National Congress l987
- COSATU
- Authors: COSATU
- Date: 1987
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/109708 , vital:33182
- Description: We the Trade Union representatives here present firmiy commit ourselves to a unified democratic South Africa, free of oppression and economic exploitation. We believe that this can only be achieved under the leadership of a united working class. Our history has taught us that to achieve this goal we will have to carry out the following tasks. To organise the unorganised workers and build effective trade unions based on the democratic organisation of workers in the factories, mines, shops, farms and other workplaces. Organise national industrial trade unions, financed and controlled by their worker members through democratically elected committees. Unify these industrial unions into a national worker controlled federation. Combat the divisions amongst the workers of South Africa and unite them into a strong and confident working class. Encourage democratic worker organisation and leadership in all spheres of our society together with other progressive sectors of the community. Reinforce and encourage progressive international worker contact and solidarity so as to assist one another in our struggles.We call on all those who identify with this commitment to join us and the workers whom we represent as comrades in the struggle ahead. We call on all trade unions to strive to unite their members in their ranks without discrimination and prejudice, and therefore resolve that this federation shall determinedly seek to further and protect the interests of all workers and that its guiding motto shall be the universal slogan of working class solidarity: "AN INJURY TO ONE IS AN INJURY TO ALL".
- Full Text:
- Date Issued: 1987
- Authors: COSATU
- Date: 1987
- Subjects: COSATU
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/109708 , vital:33182
- Description: We the Trade Union representatives here present firmiy commit ourselves to a unified democratic South Africa, free of oppression and economic exploitation. We believe that this can only be achieved under the leadership of a united working class. Our history has taught us that to achieve this goal we will have to carry out the following tasks. To organise the unorganised workers and build effective trade unions based on the democratic organisation of workers in the factories, mines, shops, farms and other workplaces. Organise national industrial trade unions, financed and controlled by their worker members through democratically elected committees. Unify these industrial unions into a national worker controlled federation. Combat the divisions amongst the workers of South Africa and unite them into a strong and confident working class. Encourage democratic worker organisation and leadership in all spheres of our society together with other progressive sectors of the community. Reinforce and encourage progressive international worker contact and solidarity so as to assist one another in our struggles.We call on all those who identify with this commitment to join us and the workers whom we represent as comrades in the struggle ahead. We call on all trade unions to strive to unite their members in their ranks without discrimination and prejudice, and therefore resolve that this federation shall determinedly seek to further and protect the interests of all workers and that its guiding motto shall be the universal slogan of working class solidarity: "AN INJURY TO ONE IS AN INJURY TO ALL".
- Full Text:
- Date Issued: 1987