Bells and bell ringers in South Africa, 1835-2000. Part II
- Authors: Lewis, Colin A
- Date: 2001
- Language: English
- Type: Article
- Identifier: vital:6165 , http://hdl.handle.net/10962/d1012353 , http://www.ringingworld.co.uk
- Description: Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
- Full Text:
- Date Issued: 2001
- Authors: Lewis, Colin A
- Date: 2001
- Language: English
- Type: Article
- Identifier: vital:6165 , http://hdl.handle.net/10962/d1012353 , http://www.ringingworld.co.uk
- Description: Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
- Full Text:
- Date Issued: 2001
In vitro release of propranolol hydrochloride from topical vehicles
- Smith, Eric W, Haigh, John M
- Authors: Smith, Eric W , Haigh, John M
- Date: 1994
- Language: English
- Type: text , Article
- Identifier: vital:6435 , http://hdl.handle.net/10962/d1006612
- Description: Transdermal drug delivery is becoming increasingly important and for this reason it is clear that academia must ensure that current graduates are knowledgeable in all facets of topical drug administration. An in vitro diffusion cell experiment was designed to demonstrate the rate of release of propranolol hydrochloride (PHC) from three different topical vehicles: (i) an oil-in-water cream; (ii) a gel; and (iii) anointment. This experiment was performed by final-year students enroled in an undergraduate course on percutaneous absorption. In vitro release of PHC from the three bases to an aqueous receptor phase through silicone membrane was monitored spectrophotometrically at a wavelength of 290 nm. By monitoring and attempting to explain the numerous possible reasons for the different rates of drug release from the three vehicles, it was hoped that the students would gain a better understanding of the complexities of transdermal drug administration. Overall, the experiment would appear to be a good model for student investigation into factors affecting the release of drugs from topical formulations.
- Full Text:
- Date Issued: 1994
- Authors: Smith, Eric W , Haigh, John M
- Date: 1994
- Language: English
- Type: text , Article
- Identifier: vital:6435 , http://hdl.handle.net/10962/d1006612
- Description: Transdermal drug delivery is becoming increasingly important and for this reason it is clear that academia must ensure that current graduates are knowledgeable in all facets of topical drug administration. An in vitro diffusion cell experiment was designed to demonstrate the rate of release of propranolol hydrochloride (PHC) from three different topical vehicles: (i) an oil-in-water cream; (ii) a gel; and (iii) anointment. This experiment was performed by final-year students enroled in an undergraduate course on percutaneous absorption. In vitro release of PHC from the three bases to an aqueous receptor phase through silicone membrane was monitored spectrophotometrically at a wavelength of 290 nm. By monitoring and attempting to explain the numerous possible reasons for the different rates of drug release from the three vehicles, it was hoped that the students would gain a better understanding of the complexities of transdermal drug administration. Overall, the experiment would appear to be a good model for student investigation into factors affecting the release of drugs from topical formulations.
- Full Text:
- Date Issued: 1994
APDUSA Views
- Date: 1989-09
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/33610 , vital:32905 , Bulk File 7
- Description: APDUSA Views was published by the African People’s Democratic Union of Southern Africa (Natal), an affiliate of the New Unity Movement.
- Full Text: false
- Date Issued: 1989-09
- Date: 1989-09
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/33610 , vital:32905 , Bulk File 7
- Description: APDUSA Views was published by the African People’s Democratic Union of Southern Africa (Natal), an affiliate of the New Unity Movement.
- Full Text: false
- Date Issued: 1989-09
A Geographic Information System for the African Coelacanth Ecosystem Programme
- Authors: Scott, Lucy E P
- Date: 2006
- Language: English
- Type: Article
- Identifier: vital:7129 , http://hdl.handle.net/10962/d1010639
- Description: The African Coelacanth Ecosystem Programme (ACEP) Geographic Information System (GIS) has been developed to integrate, analyse and map all spatial data generated within the ACEP programme. A GIS is a multidisciplinary tool, and within ACEP the GIS has been used to integrate information from marine biology studies, oceanographic surveys, geophysical exploration as well as the observations made and footage taken from a research submersible. The core data in the GIS are based on deep marine ecosystems and the programme’s flagship species, Latimeria chalumnae (the coelacanth). Over and above the utility of the GIS as a tool for science through its considerable information storage, analysis and display capabilities, the ACEP GIS has been used for interactive environmental education purposes and to generate public awareness of the programme at various meetings, training events and conferences.
- Full Text:
- Date Issued: 2006
- Authors: Scott, Lucy E P
- Date: 2006
- Language: English
- Type: Article
- Identifier: vital:7129 , http://hdl.handle.net/10962/d1010639
- Description: The African Coelacanth Ecosystem Programme (ACEP) Geographic Information System (GIS) has been developed to integrate, analyse and map all spatial data generated within the ACEP programme. A GIS is a multidisciplinary tool, and within ACEP the GIS has been used to integrate information from marine biology studies, oceanographic surveys, geophysical exploration as well as the observations made and footage taken from a research submersible. The core data in the GIS are based on deep marine ecosystems and the programme’s flagship species, Latimeria chalumnae (the coelacanth). Over and above the utility of the GIS as a tool for science through its considerable information storage, analysis and display capabilities, the ACEP GIS has been used for interactive environmental education purposes and to generate public awareness of the programme at various meetings, training events and conferences.
- Full Text:
- Date Issued: 2006
Dedication of Jo'burg's new ring
- Authors: Lewis, Colin A
- Date: 2009
- Language: English
- Type: Article
- Identifier: vital:6189 , http://hdl.handle.net/10962/d1012395 , http://www.ringingworld.co.uk
- Description: Five years of planning, fund raising and hard work came to fruition in November 2008 when Africa's newest ring of bells was dedicated, bringing the first part of the Jo'burg Project to a successful conclusion.
- Full Text:
- Date Issued: 2009
- Authors: Lewis, Colin A
- Date: 2009
- Language: English
- Type: Article
- Identifier: vital:6189 , http://hdl.handle.net/10962/d1012395 , http://www.ringingworld.co.uk
- Description: Five years of planning, fund raising and hard work came to fruition in November 2008 when Africa's newest ring of bells was dedicated, bringing the first part of the Jo'burg Project to a successful conclusion.
- Full Text:
- Date Issued: 2009
Establishing a basis for ecosystem management in the western Indian Ocean
- Vousden, David, Scott, Lucy E P, Sauer, Warwick H H, Bornman, T G, Ngoile, M, Stapley, J, Lutjeharms, Johan R E
- Authors: Vousden, David , Scott, Lucy E P , Sauer, Warwick H H , Bornman, T G , Ngoile, M , Stapley, J , Lutjeharms, Johan R E
- Date: 2008
- Language: English
- Type: Article
- Identifier: vital:6774 , http://hdl.handle.net/10962/d1008081
- Description: An ambitious multinational programme, with generous funding for an initial five years, aims to provide understanding of marine resources for the benefit of impoverished island and coastal populations in a much-neglected ocean region.
- Full Text:
- Date Issued: 2008
- Authors: Vousden, David , Scott, Lucy E P , Sauer, Warwick H H , Bornman, T G , Ngoile, M , Stapley, J , Lutjeharms, Johan R E
- Date: 2008
- Language: English
- Type: Article
- Identifier: vital:6774 , http://hdl.handle.net/10962/d1008081
- Description: An ambitious multinational programme, with generous funding for an initial five years, aims to provide understanding of marine resources for the benefit of impoverished island and coastal populations in a much-neglected ocean region.
- Full Text:
- Date Issued: 2008
The structure of aliphatic amine adducts of uranyl acetylacetonate. I. Dioxobis(2,4-pentanedionato)mono (2-N-methylaminopentan-4-one)uranium(VI)
- Haigh, John M, Nassimbeni, Luigi R, Pauptit, Richard A, Rodgers, Allen L, Sheldrick, George M
- Authors: Haigh, John M , Nassimbeni, Luigi R , Pauptit, Richard A , Rodgers, Allen L , Sheldrick, George M
- Date: 1976
- Subjects: Aliphatic amine adducts , Uranyl acetylacetonate
- Language: English
- Type: Article , text
- Identifier: vital:6373 , http://hdl.handle.net/10962/d1006077
- Description: Crystals of the title compound are monoclinic with a= 8.314 (5), b= 22.723 (9), c= 12.589 (6) A, /3= 123.0 (2t, Z=4, space group P2dc. The structure was determined by Patterson and Fourier methods and refined by full-matrix least squares to a final R of 0.030 for 2043 independent reflexions. The U atom has pentagonal bipyramidal coordination and the N-methylacetylacetoneamine is bonded to U via O. There are two intramolecular N-H. . .0 hydrogen bonds which govern the geometry of the adduct molecule.
- Full Text:
- Date Issued: 1976
- Authors: Haigh, John M , Nassimbeni, Luigi R , Pauptit, Richard A , Rodgers, Allen L , Sheldrick, George M
- Date: 1976
- Subjects: Aliphatic amine adducts , Uranyl acetylacetonate
- Language: English
- Type: Article , text
- Identifier: vital:6373 , http://hdl.handle.net/10962/d1006077
- Description: Crystals of the title compound are monoclinic with a= 8.314 (5), b= 22.723 (9), c= 12.589 (6) A, /3= 123.0 (2t, Z=4, space group P2dc. The structure was determined by Patterson and Fourier methods and refined by full-matrix least squares to a final R of 0.030 for 2043 independent reflexions. The U atom has pentagonal bipyramidal coordination and the N-methylacetylacetoneamine is bonded to U via O. There are two intramolecular N-H. . .0 hydrogen bonds which govern the geometry of the adduct molecule.
- Full Text:
- Date Issued: 1976
Evaluation of the proposed FDA pilot-dose response methodology for topical corticosteroid bioeqivalence testing [authors' reply in Letters to the Editor]
- Smith, Eric W, Walker, Roderick B, Haigh, John M, Kanfer, Isadore
- Authors: Smith, Eric W , Walker, Roderick B , Haigh, John M , Kanfer, Isadore
- Date: 1998
- Language: English
- Type: text , Article
- Identifier: vital:6423 , http://hdl.handle.net/10962/d1006558
- Description: Reply to: Letter to the Editor by Singh GJ; Fleischer N; Lesko L; Williams R - relating to original article in Pharmaceutical Research (USA), Mar 1997, vol. 14, pp. 303-308.
- Full Text: false
- Date Issued: 1998
- Authors: Smith, Eric W , Walker, Roderick B , Haigh, John M , Kanfer, Isadore
- Date: 1998
- Language: English
- Type: text , Article
- Identifier: vital:6423 , http://hdl.handle.net/10962/d1006558
- Description: Reply to: Letter to the Editor by Singh GJ; Fleischer N; Lesko L; Williams R - relating to original article in Pharmaceutical Research (USA), Mar 1997, vol. 14, pp. 303-308.
- Full Text: false
- Date Issued: 1998
Suitability of total coliform beta-D-galactosidase activity and CFU counts in monitoring faecal contamination of environmental water samples
- Wutor, V C, Togo, C A, Pletschke, Brett I
- Authors: Wutor, V C , Togo, C A , Pletschke, Brett I
- Date: 2009
- Language: English
- Type: Article
- Identifier: vital:6477 , http://hdl.handle.net/10962/d1006165 , http://www.scielo.org.za/scielo.php?pid=S1816-79502009000100010&script=sci_arttext
- Description: Total coliforms are a group of bacteria found in high numbers in mammalian intestines; hence their presence in water indicates the possible contamination with faecal material. Total and faecal coliform counts were monitored over a period of 18 months using mFC, m-Endo and CM1046 media together with enzymatic assays on 215 environmental water samples obtained from the Eastern Cape Province of South Africa. A positive correlation, with an R2 value of 0.9393 was observed between faecal and total coliform colony units employing mFc and m-Endo media, and 0.8818 using CM1046 media. Also, a positive correlation was observed between Escherichia coli colony-forming units and β-D-galactosidase (B-GAL) activity (R2=0.8542). Overall, this study indicated that faecal contamination of environmental water samples could be monitored by measuring total coliform β-galactosidase activity and total coliform colony-forming units.
- Full Text: false
- Date Issued: 2009
- Authors: Wutor, V C , Togo, C A , Pletschke, Brett I
- Date: 2009
- Language: English
- Type: Article
- Identifier: vital:6477 , http://hdl.handle.net/10962/d1006165 , http://www.scielo.org.za/scielo.php?pid=S1816-79502009000100010&script=sci_arttext
- Description: Total coliforms are a group of bacteria found in high numbers in mammalian intestines; hence their presence in water indicates the possible contamination with faecal material. Total and faecal coliform counts were monitored over a period of 18 months using mFC, m-Endo and CM1046 media together with enzymatic assays on 215 environmental water samples obtained from the Eastern Cape Province of South Africa. A positive correlation, with an R2 value of 0.9393 was observed between faecal and total coliform colony units employing mFc and m-Endo media, and 0.8818 using CM1046 media. Also, a positive correlation was observed between Escherichia coli colony-forming units and β-D-galactosidase (B-GAL) activity (R2=0.8542). Overall, this study indicated that faecal contamination of environmental water samples could be monitored by measuring total coliform β-galactosidase activity and total coliform colony-forming units.
- Full Text: false
- Date Issued: 2009
A yellowwood by any other name: molecular systematics and the taxonomy of Podocarpus and the Podocarpaceae in southern Africa
- Barker, Nigel P, Muller, E M, Mill, R R
- Authors: Barker, Nigel P , Muller, E M , Mill, R R
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6495 , http://hdl.handle.net/10962/d1004488
- Description: We briefly review the taxonomic history of the Podocarpaceae, with an emphasis on the recognition of numerous segregate genera out of Podocarpus sensu lato. Despite some controversy over the recognition of these genera, molecular data (DNA sequences) provide evidence that supports this taxonomy. The implications for African Podocarpaceae are discussed. In particular, molecular data support the recognition of Afrocarpus as distinct from Podocarpus. Additional taxonomic problems concerning the possible segregation of Podocarpus milanjianus from P. latifolius are addressed using DNA sequence data from the nuclear internal transcribed spacer 2 (ITS2) region. Results of this are inconclusive, and suggest that alternative DNA-based evidence, such as from AFLPs or microsatellites, may be more informative in resolving such species complexes in African Podocarpus.
- Full Text:
- Date Issued: 2004
- Authors: Barker, Nigel P , Muller, E M , Mill, R R
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6495 , http://hdl.handle.net/10962/d1004488
- Description: We briefly review the taxonomic history of the Podocarpaceae, with an emphasis on the recognition of numerous segregate genera out of Podocarpus sensu lato. Despite some controversy over the recognition of these genera, molecular data (DNA sequences) provide evidence that supports this taxonomy. The implications for African Podocarpaceae are discussed. In particular, molecular data support the recognition of Afrocarpus as distinct from Podocarpus. Additional taxonomic problems concerning the possible segregation of Podocarpus milanjianus from P. latifolius are addressed using DNA sequence data from the nuclear internal transcribed spacer 2 (ITS2) region. Results of this are inconclusive, and suggest that alternative DNA-based evidence, such as from AFLPs or microsatellites, may be more informative in resolving such species complexes in African Podocarpus.
- Full Text:
- Date Issued: 2004
Doing the twist: a test of Darwin's cross-pollination hypothesis for pollinarium reconfiguration
- Peter, Craig I, Johnson, Steven D
- Authors: Peter, Craig I , Johnson, Steven D
- Date: 2006
- Language: English
- Type: Article
- Identifier: vital:6534 , http://hdl.handle.net/10962/d1005975
- Description: Mating success in plants depends largely on the efficiency of pollen dispersal. For hermaphrodite plants, self-pollination, either within or among flowers, can reduce mating opportunities because of pollen and ovule discounting and inbreeding depression. Self-pollination may be particularly detrimental in plants such as orchids and asclepiads that package each flower’s pollen into one or more pollinia which, together with accessory structures, comprise a pollinarium. Darwin proposed that physical reconfiguration of pollinaria serves as a mechanism for reducing the likelihood of self-pollination. To be effective, the time taken for pollinarium reconfiguration would need to exceed that spent by a pollinator on a plant. We investigated pollinarium reconfiguration (including pollinarium bending, pollinium shrinking and anther cap retention) in 19 species and found a strong positive relationship between reconfiguration time and the duration of pollinator visits. Reconfiguration times were also consistently longer than pollinator visit times. These results provide strong support for Darwin’s idea that this mechanism promotes cross-pollination. , Elsevier
- Full Text:
- Date Issued: 2006
- Authors: Peter, Craig I , Johnson, Steven D
- Date: 2006
- Language: English
- Type: Article
- Identifier: vital:6534 , http://hdl.handle.net/10962/d1005975
- Description: Mating success in plants depends largely on the efficiency of pollen dispersal. For hermaphrodite plants, self-pollination, either within or among flowers, can reduce mating opportunities because of pollen and ovule discounting and inbreeding depression. Self-pollination may be particularly detrimental in plants such as orchids and asclepiads that package each flower’s pollen into one or more pollinia which, together with accessory structures, comprise a pollinarium. Darwin proposed that physical reconfiguration of pollinaria serves as a mechanism for reducing the likelihood of self-pollination. To be effective, the time taken for pollinarium reconfiguration would need to exceed that spent by a pollinator on a plant. We investigated pollinarium reconfiguration (including pollinarium bending, pollinium shrinking and anther cap retention) in 19 species and found a strong positive relationship between reconfiguration time and the duration of pollinator visits. Reconfiguration times were also consistently longer than pollinator visit times. These results provide strong support for Darwin’s idea that this mechanism promotes cross-pollination. , Elsevier
- Full Text:
- Date Issued: 2006
Reflecting on the next generation of models for community-based natural resources management
- Shackleton, Charlie M, Willis, T V, Brown, K, Polunin, N
- Authors: Shackleton, Charlie M , Willis, T V , Brown, K , Polunin, N
- Date: 2010
- Language: English
- Type: Article
- Identifier: vital:6659 , http://hdl.handle.net/10962/d1007083
- Description: Community-based natural resource management (CBNRM) has been a pervasive paradigm in conservation circles for three decades. Despite many potentially attractive attributes it has been extensively critiqued from both ecological and sociological perspectives with respect to theory and practice (for example Leach et al. 1999; Berkes 2004; Fabricius et al. 2004; Blaikie 2006). Nonetheless, many successful examples exist, although an equal number have seemingly not met expectations. Is this because of poor implementation or rather a generally flawed model? If the criteria and conditions for success are so onerous that relatively few projects or situations are likely to qualify, what then is the value of the model? The questions thus become: how and what can we learn from the past theory and practice to develop a new generation of flexible, locally responsive and implementable CBNRM models, and what are likely to be the attributes of such models?
- Full Text:
- Date Issued: 2010
- Authors: Shackleton, Charlie M , Willis, T V , Brown, K , Polunin, N
- Date: 2010
- Language: English
- Type: Article
- Identifier: vital:6659 , http://hdl.handle.net/10962/d1007083
- Description: Community-based natural resource management (CBNRM) has been a pervasive paradigm in conservation circles for three decades. Despite many potentially attractive attributes it has been extensively critiqued from both ecological and sociological perspectives with respect to theory and practice (for example Leach et al. 1999; Berkes 2004; Fabricius et al. 2004; Blaikie 2006). Nonetheless, many successful examples exist, although an equal number have seemingly not met expectations. Is this because of poor implementation or rather a generally flawed model? If the criteria and conditions for success are so onerous that relatively few projects or situations are likely to qualify, what then is the value of the model? The questions thus become: how and what can we learn from the past theory and practice to develop a new generation of flexible, locally responsive and implementable CBNRM models, and what are likely to be the attributes of such models?
- Full Text:
- Date Issued: 2010
The Guild comes of age! Peals and quarters at South African Guild meetings, 1988-2008. Part 1
- Authors: Lewis, Colin A
- Date: 2008
- Language: English
- Type: Article
- Identifier: vital:6187 , http://hdl.handle.net/10962/d1012386
- Description: The founding meeting of the South African Guild was held in Grahamstown during the first weekend of July 1988. Dedication of the bells and new frame at Grahamstown cathedral marked the completion of the first Guild project to ensure that all rings of bells in South Africa were in good condition. This first part of the article takes us up to the completion of the Grahamstown restoration. , Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
- Full Text:
- Date Issued: 2008
- Authors: Lewis, Colin A
- Date: 2008
- Language: English
- Type: Article
- Identifier: vital:6187 , http://hdl.handle.net/10962/d1012386
- Description: The founding meeting of the South African Guild was held in Grahamstown during the first weekend of July 1988. Dedication of the bells and new frame at Grahamstown cathedral marked the completion of the first Guild project to ensure that all rings of bells in South Africa were in good condition. This first part of the article takes us up to the completion of the Grahamstown restoration. , Colin Lewis was Professor of Geography at Rhodes University, Grahamstown, South Africa from 1989 until his retirement at the end of 2007. In 1990, with the strong support of the incumbent Vice-Chancellor, Dr Derek Henderson, he instigated the Certificate in Change Ringing (Church Bell Ringing) in the Rhodes University Department of Music and Musicology - the first such course to be offered in Africa. Since that date he has lectured in the basic theory, and taught the practice of change ringing. He is the Ringing Master of the Cathedral of St Michael and St George, Grahamstown, South Africa.
- Full Text:
- Date Issued: 2008
Blanching activities of betamethasone 17-valerate formulations: effect of the dosage form on topical drug availability
- Smith, Eric W, Meyer, Eric, Haigh, John M
- Authors: Smith, Eric W , Meyer, Eric , Haigh, John M
- Date: 1990
- Language: English
- Type: Article
- Identifier: vital:6432 , http://hdl.handle.net/10962/d1006602
- Description: The blanching activities of Betnovate© cream, lotion, ointment and scalp application (each containing 0.1 % betamethasone (as the 17-valerate)) were determined using healthy human subjects over a 32 h period in both the occludedand unoccluded modes. Considering that allfour formulation types contained the same label concentration of corticosteroid,it may bepresumed that theformulations would show similar topical drug availability: this was, however, not found to be the case. The scalp application demonstrated the highest topical availability in both the occluded and unoccluded modes. The lotion formulation showed the greatest increase in topical availability on occlusion and the ointment formulation was the least sensitive to the effects of occlusion. These differences, due solely to the effects of the vehicle, may have important clinical implications.
- Full Text:
- Date Issued: 1990
- Authors: Smith, Eric W , Meyer, Eric , Haigh, John M
- Date: 1990
- Language: English
- Type: Article
- Identifier: vital:6432 , http://hdl.handle.net/10962/d1006602
- Description: The blanching activities of Betnovate© cream, lotion, ointment and scalp application (each containing 0.1 % betamethasone (as the 17-valerate)) were determined using healthy human subjects over a 32 h period in both the occludedand unoccluded modes. Considering that allfour formulation types contained the same label concentration of corticosteroid,it may bepresumed that theformulations would show similar topical drug availability: this was, however, not found to be the case. The scalp application demonstrated the highest topical availability in both the occluded and unoccluded modes. The lotion formulation showed the greatest increase in topical availability on occlusion and the ointment formulation was the least sensitive to the effects of occlusion. These differences, due solely to the effects of the vehicle, may have important clinical implications.
- Full Text:
- Date Issued: 1990
APDUSA Views
- Date: 1987-02
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/32982 , vital:32487 , Bulk File 7
- Description: APDUSA Views was published by the African People’s Democratic Union of Southern Africa (Natal), an affiliate of the New Unity Movement.
- Full Text: false
- Date Issued: 1987-02
- Date: 1987-02
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/32982 , vital:32487 , Bulk File 7
- Description: APDUSA Views was published by the African People’s Democratic Union of Southern Africa (Natal), an affiliate of the New Unity Movement.
- Full Text: false
- Date Issued: 1987-02
Isolation of genes encoding heat shock protein 70 (hsp70s) from the coelacanth, Latimeria chalumnae
- Modisakeng, Keoagile W, Dorrington, Rosemary A, Blatch, Gregory L
- Authors: Modisakeng, Keoagile W , Dorrington, Rosemary A , Blatch, Gregory L
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6459 , http://hdl.handle.net/10962/d1005788
- Description: Under stress conditions, proteins unfold or misfold, leading to the formation of aggregates. Molecular chaperones can be defined as proteins that facilitate the correct folding of other proteins, so that they attain a stable tertiary structure. In addition, they promote the refolding and degradation of denatured proteins after cellular stress. Heat shock proteins form one of the main classes of molecular chaperones. We are interested in determining if the genome of the coelacanth (Latimeria chalumnae) encodes a heat shock protein-based cytoprotection mechanism. We have isolated 50 kb and larger coelacanth genomic DNA from frozen skin tissue of L. chalumnae. From the alignments of several fish Hsp70 proteins, conserved regions at the N- and C-termini were identified. Codon usage tables were constructed from published coelacanth genes and degenerate primers were designed to isolate the full-length hsp70 gene and regions encoding the ATPase and the peptide binding domains. Since it is known that the tilapia and Fugu inducible hsp70 genes are intronless, we proceeded on the assumption that a coelacanth inducible hsp70 would also be intronless. A large fragment (1840 bp) encoding most of a coelacanth Hsp70 protein, and two partial fragments encoding a coelacanth Hsp70ATPase domain (1048 bp) and peptide binding domain (873 bp), were isolated by polymerase chain reaction amplification. Protein sequences translated from all the nucleotide sequences were closely identical to typical Hsp70s. This is the first study to provide evidence for a cytoprotection mechanism in the coelacanth involving an inducible Hsp70.
- Full Text:
- Date Issued: 2004
- Authors: Modisakeng, Keoagile W , Dorrington, Rosemary A , Blatch, Gregory L
- Date: 2004
- Language: English
- Type: Article
- Identifier: vital:6459 , http://hdl.handle.net/10962/d1005788
- Description: Under stress conditions, proteins unfold or misfold, leading to the formation of aggregates. Molecular chaperones can be defined as proteins that facilitate the correct folding of other proteins, so that they attain a stable tertiary structure. In addition, they promote the refolding and degradation of denatured proteins after cellular stress. Heat shock proteins form one of the main classes of molecular chaperones. We are interested in determining if the genome of the coelacanth (Latimeria chalumnae) encodes a heat shock protein-based cytoprotection mechanism. We have isolated 50 kb and larger coelacanth genomic DNA from frozen skin tissue of L. chalumnae. From the alignments of several fish Hsp70 proteins, conserved regions at the N- and C-termini were identified. Codon usage tables were constructed from published coelacanth genes and degenerate primers were designed to isolate the full-length hsp70 gene and regions encoding the ATPase and the peptide binding domains. Since it is known that the tilapia and Fugu inducible hsp70 genes are intronless, we proceeded on the assumption that a coelacanth inducible hsp70 would also be intronless. A large fragment (1840 bp) encoding most of a coelacanth Hsp70 protein, and two partial fragments encoding a coelacanth Hsp70ATPase domain (1048 bp) and peptide binding domain (873 bp), were isolated by polymerase chain reaction amplification. Protein sequences translated from all the nucleotide sequences were closely identical to typical Hsp70s. This is the first study to provide evidence for a cytoprotection mechanism in the coelacanth involving an inducible Hsp70.
- Full Text:
- Date Issued: 2004
Energy versus angular momentum in black hole binaries
- Damour, T, Nagar, A, Pollney, D, Reisswig, C
- Authors: Damour, T , Nagar, A , Pollney, D , Reisswig, C
- Date: 2011
- Language: English
- Type: Article
- Identifier: vital:6792 , http://hdl.handle.net/10962/d1006946
- Description: Using accurate numerical-relativity simulations of (nonspinning) black-hole binaries with mass ratios 1∶1, 2∶1, and 3∶1, we compute the gauge-invariant relation between the (reduced) binding energy E and the (reduced) angular momentum j of the system. We show that the relation E(j) is an accurate diagnostic of the dynamics of a black-hole binary in a highly relativistic regime. By comparing the numerical-relativity ENR(j) curve with the predictions of several analytic approximation schemes, we find that, while the canonically defined, nonresummed post-Newtonian–expanded EPN(j) relation exhibits large and growing deviations from ENR(j), the prediction of the effective one body formalism, based purely on known analytical results (without any calibration to numerical relativity), agrees strikingly well with the numerical-relativity results.
- Full Text:
- Date Issued: 2011
- Authors: Damour, T , Nagar, A , Pollney, D , Reisswig, C
- Date: 2011
- Language: English
- Type: Article
- Identifier: vital:6792 , http://hdl.handle.net/10962/d1006946
- Description: Using accurate numerical-relativity simulations of (nonspinning) black-hole binaries with mass ratios 1∶1, 2∶1, and 3∶1, we compute the gauge-invariant relation between the (reduced) binding energy E and the (reduced) angular momentum j of the system. We show that the relation E(j) is an accurate diagnostic of the dynamics of a black-hole binary in a highly relativistic regime. By comparing the numerical-relativity ENR(j) curve with the predictions of several analytic approximation schemes, we find that, while the canonically defined, nonresummed post-Newtonian–expanded EPN(j) relation exhibits large and growing deviations from ENR(j), the prediction of the effective one body formalism, based purely on known analytical results (without any calibration to numerical relativity), agrees strikingly well with the numerical-relativity results.
- Full Text:
- Date Issued: 2011
Studying the impact of ocean eddies on the ecosystem of the Prince Edward Islands: DEIMEC ll
- Pakhomov, E A, Ansorge, Isabelle J, Kaehler, Sven, Vumazonke, Lukhanyiso U, Gulekana, K, Bushula, T, Balt, C, Paul, D, Hargey, N, Stewart, H, Chang, N, Furno, L, Mkatshwa, S, Visser, C, Lutjeharms, Johan R E, Hayes-Foley, P
- Authors: Pakhomov, E A , Ansorge, Isabelle J , Kaehler, Sven , Vumazonke, Lukhanyiso U , Gulekana, K , Bushula, T , Balt, C , Paul, D , Hargey, N , Stewart, H , Chang, N , Furno, L , Mkatshwa, S , Visser, C , Lutjeharms, Johan R E , Hayes-Foley, P
- Date: 2003
- Language: English
- Type: Article
- Identifier: vital:6932 , http://hdl.handle.net/10962/d1011952
- Description: The Dynamics of Eddy Impacts on Marion’s Ecosystem Study (DEIMEC) programme was begun in 2002 with the aim of understanding the importance of the oceanic, upstream environment to the ecosystem of the Prince Edward Islands. This island group consists of two small volcanic islands and provides many opportunities for studying ecological and evolutionary processes, for monitoring ecological changes in relation to global climate change and for conserving a unique component of the planet’s biological diversity.
- Full Text:
- Date Issued: 2003
- Authors: Pakhomov, E A , Ansorge, Isabelle J , Kaehler, Sven , Vumazonke, Lukhanyiso U , Gulekana, K , Bushula, T , Balt, C , Paul, D , Hargey, N , Stewart, H , Chang, N , Furno, L , Mkatshwa, S , Visser, C , Lutjeharms, Johan R E , Hayes-Foley, P
- Date: 2003
- Language: English
- Type: Article
- Identifier: vital:6932 , http://hdl.handle.net/10962/d1011952
- Description: The Dynamics of Eddy Impacts on Marion’s Ecosystem Study (DEIMEC) programme was begun in 2002 with the aim of understanding the importance of the oceanic, upstream environment to the ecosystem of the Prince Edward Islands. This island group consists of two small volcanic islands and provides many opportunities for studying ecological and evolutionary processes, for monitoring ecological changes in relation to global climate change and for conserving a unique component of the planet’s biological diversity.
- Full Text:
- Date Issued: 2003
Potency ranking of two new topical corticosteroid creams containing 0.1% desonide or 0.05% halometasone utilizing the human skin-blanching assay
- Meyer, Eric, Smith, Eric W, Haigh, John M, Kanfer, Isadore
- Authors: Meyer, Eric , Smith, Eric W , Haigh, John M , Kanfer, Isadore
- Date: 1988
- Language: English
- Type: Article
- Identifier: vital:6400 , http://hdl.handle.net/10962/d1006327
- Description: The human blanching assay was used to assess the potency of two new proprietary corticosteroid creams. The blanching abilities of 0.1% desonide cream and 0.05% halometasone cream were evaluated relative to the blanching elicited by 0.05% clobetasol 17-propionate cream, 0.1% betamethasone 17-valerate cream and 0.05% clobetasone 17-butyrate cream. The results of the trial indicated that the 0.1% desonide cream falls into the potent group of topical corticosteroid preparations and the 0.05% halomethasone cream falls into the moderately potent group.
- Full Text:
- Date Issued: 1988
- Authors: Meyer, Eric , Smith, Eric W , Haigh, John M , Kanfer, Isadore
- Date: 1988
- Language: English
- Type: Article
- Identifier: vital:6400 , http://hdl.handle.net/10962/d1006327
- Description: The human blanching assay was used to assess the potency of two new proprietary corticosteroid creams. The blanching abilities of 0.1% desonide cream and 0.05% halometasone cream were evaluated relative to the blanching elicited by 0.05% clobetasol 17-propionate cream, 0.1% betamethasone 17-valerate cream and 0.05% clobetasone 17-butyrate cream. The results of the trial indicated that the 0.1% desonide cream falls into the potent group of topical corticosteroid preparations and the 0.05% halomethasone cream falls into the moderately potent group.
- Full Text:
- Date Issued: 1988
An empirical formula for estimating the water use of Scaevola plumieri
- Peter, Craig I, Ripley, Bradley S
- Authors: Peter, Craig I , Ripley, Bradley S
- Date: 2000
- Language: English
- Type: Article
- Identifier: vital:6530 , http://hdl.handle.net/10962/d1005971
- Description: Transpirational water loss of Scaevola plumieri (L) Vahl. (= Scaevola thunbergii Eckl. & Zeyh.) (Goodeniaceae), a dune pioneer plant along the eastern and southern coasts of South Africa, was measured over a wide range of atmospheric conditions and related to the atmospheric vapour pressure deficit (VPD). A plot of leaf transpiration rate (E) against VPD yielded a curvilinear relationship (r[sup 2] = 0.88, P = 0.000). As both leaf and canopy E were found to be closely coupled to atmospheric conditions, this correlation was used to calculate canopy E for entire days. The bulk volumes of water transpired per day were related to the mean daily temperature as recorded at a nearby weather station and were strongly related (r2 = 0.71, P = 0.0037). This correlation allowed the bulk volume of water transpired by one square metre of a S. plumieri-covered dune to be calculated on a daily basis for an entire year. Transpirational losses (566 litres) in 1997 were then compared with rainfall (539 litres), indicating that rainfall was perhaps insufficient to support the plants that year. Similar deficits were calculated for 1996, suggesting that plants were possibly reliant on water stored in the sand or taped ground water. This species showed an unusual positive response of increasing leaf conductance to increasing VPD over the range 0-3 kPa.
- Full Text: false
- Date Issued: 2000
- Authors: Peter, Craig I , Ripley, Bradley S
- Date: 2000
- Language: English
- Type: Article
- Identifier: vital:6530 , http://hdl.handle.net/10962/d1005971
- Description: Transpirational water loss of Scaevola plumieri (L) Vahl. (= Scaevola thunbergii Eckl. & Zeyh.) (Goodeniaceae), a dune pioneer plant along the eastern and southern coasts of South Africa, was measured over a wide range of atmospheric conditions and related to the atmospheric vapour pressure deficit (VPD). A plot of leaf transpiration rate (E) against VPD yielded a curvilinear relationship (r[sup 2] = 0.88, P = 0.000). As both leaf and canopy E were found to be closely coupled to atmospheric conditions, this correlation was used to calculate canopy E for entire days. The bulk volumes of water transpired per day were related to the mean daily temperature as recorded at a nearby weather station and were strongly related (r2 = 0.71, P = 0.0037). This correlation allowed the bulk volume of water transpired by one square metre of a S. plumieri-covered dune to be calculated on a daily basis for an entire year. Transpirational losses (566 litres) in 1997 were then compared with rainfall (539 litres), indicating that rainfall was perhaps insufficient to support the plants that year. Similar deficits were calculated for 1996, suggesting that plants were possibly reliant on water stored in the sand or taped ground water. This species showed an unusual positive response of increasing leaf conductance to increasing VPD over the range 0-3 kPa.
- Full Text: false
- Date Issued: 2000