Iodine nutrition status in Africa: Potentially high prevalence of iodine deficiency in pregnancy even in countries classified as iodine sufficient
- Charles Bitamazire Businge, Benjamin Longo-Mbenza, Andre Pascal Kengne
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 03-8-2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3377 , vital:43336 , https://www.cambridge.org/core/journals/public-health-nutrition/article/iodine-nutrition-status-in-africa-potentially-high-prevalence-of-iodine-deficiency-in-pregnancy-even-in-countries-classified-as-iodine-sufficient/B3DCB06E75CDDD8EAD410BE090198BA4
- Description: Objective: To assess the burden of iodine deficiency in pregnancy in Africa using estimated pregnancy median urinary iodine concentration (pMUIC). Design: pMUIC for each African country was estimated using a regression equation derived by correlating the school-age children (SAC) median UIC (mUIC) and pMUIC from countries around the globe, and the SAC mUIC data for African countries obtained from the Iodine Global Network (IGN) 2017 and 2019 Score cards. Setting: Iodine deficiency was endemic in many African countries before the introduction of iodine fortification, mainly through universal salt iodisation programmes about 25 years ago. There is a scarcity of data on the level of iodine nutrition in pregnancy in Africa. Women living in settings with pMUIC below 150 μg/l are at risk of iodine deficiency-related pregnancy complications. Participants: Fifty of the fifty-five African countries that had data on iodine nutrition status. Results: A cut-off school age mUIC ≤ 175 μg/l is correlated with insufficient iodine intake in pregnancy (pregnancy mUIC ≤ 150 μg/l). Twenty-two African countries had SAC mUIC less than 175 μg/l, which correlated with insufficient iodine intake during pregnancy (pMUIC less than 150 μg/l). However, nine of these twenty-two countries had adequate iodine intake based on SAC mUIC. Conclusions: There is likely a high prevalence of insufficient iodine intake in pregnancy, including in some African countries classified as having adequate iodine intake in the general population. A SAC mUIC ≤ 175 μ
- Full Text:
- Date Issued: 03-8-2020
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Andre Pascal Kengne
- Date: 03-8-2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/3377 , vital:43336 , https://www.cambridge.org/core/journals/public-health-nutrition/article/iodine-nutrition-status-in-africa-potentially-high-prevalence-of-iodine-deficiency-in-pregnancy-even-in-countries-classified-as-iodine-sufficient/B3DCB06E75CDDD8EAD410BE090198BA4
- Description: Objective: To assess the burden of iodine deficiency in pregnancy in Africa using estimated pregnancy median urinary iodine concentration (pMUIC). Design: pMUIC for each African country was estimated using a regression equation derived by correlating the school-age children (SAC) median UIC (mUIC) and pMUIC from countries around the globe, and the SAC mUIC data for African countries obtained from the Iodine Global Network (IGN) 2017 and 2019 Score cards. Setting: Iodine deficiency was endemic in many African countries before the introduction of iodine fortification, mainly through universal salt iodisation programmes about 25 years ago. There is a scarcity of data on the level of iodine nutrition in pregnancy in Africa. Women living in settings with pMUIC below 150 μg/l are at risk of iodine deficiency-related pregnancy complications. Participants: Fifty of the fifty-five African countries that had data on iodine nutrition status. Results: A cut-off school age mUIC ≤ 175 μg/l is correlated with insufficient iodine intake in pregnancy (pregnancy mUIC ≤ 150 μg/l). Twenty-two African countries had SAC mUIC less than 175 μg/l, which correlated with insufficient iodine intake during pregnancy (pMUIC less than 150 μg/l). However, nine of these twenty-two countries had adequate iodine intake based on SAC mUIC. Conclusions: There is likely a high prevalence of insufficient iodine intake in pregnancy, including in some African countries classified as having adequate iodine intake in the general population. A SAC mUIC ≤ 175 μ
- Full Text:
- Date Issued: 03-8-2020
Job summit - reading pack: prepared for TCOE
- Trade Union Library & Education Centre
- Authors: Trade Union Library & Education Centre
- Date: 19uu
- Subjects: Uncatalogued
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/60362 , vital:27773
- Description: Reading pack compiled in view of the Job Summit as emerged from Nedlac's Labour Market Commission report released in 1996.
- Full Text:
- Date Issued: 19uu
- Authors: Trade Union Library & Education Centre
- Date: 19uu
- Subjects: Uncatalogued
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/60362 , vital:27773
- Description: Reading pack compiled in view of the Job Summit as emerged from Nedlac's Labour Market Commission report released in 1996.
- Full Text:
- Date Issued: 19uu
NUMSA’s bargaining process
- National Union of Metalworkers of South Africa
- Authors: National Union of Metalworkers of South Africa
- Date: 19--?
- Subjects: Uncatalogued
- Language: eng
- Type: text , pamphlet
- Identifier: http://hdl.handle.net/10962/104517 , vital:32394
- Full Text:
- Date Issued: 19--?
- Authors: National Union of Metalworkers of South Africa
- Date: 19--?
- Subjects: Uncatalogued
- Language: eng
- Type: text , pamphlet
- Identifier: http://hdl.handle.net/10962/104517 , vital:32394
- Full Text:
- Date Issued: 19--?
South African Coloured National Convention, Claremont Civic Centre, 7th to 10th July 1961
- Authors: Convention Central Office
- Date: 1961
- Subjects: Coloured National Convention , Colored people (South Africa) , Civil rights -- South Africa , Apartheid -- South Africa , South Africa -- Race relations -- 20th century , South Africa -- Social conditions -- 1961-1994 , Human rights -- South Africa -- History -- 20th century , South Africa. South African Coloured National Convention
- Type: Text
- Identifier: http://hdl.handle.net/10962/31245 , vital:23928 , MS 10 801 , This manuscript is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
- Description: Programme outline for the South African Coloured National Convention, which took place in Claremont Civic Centre, Cape Town, from the 7th to the 10th of July 1961.
- Full Text:
- Date Issued: 1961
- Authors: Convention Central Office
- Date: 1961
- Subjects: Coloured National Convention , Colored people (South Africa) , Civil rights -- South Africa , Apartheid -- South Africa , South Africa -- Race relations -- 20th century , South Africa -- Social conditions -- 1961-1994 , Human rights -- South Africa -- History -- 20th century , South Africa. South African Coloured National Convention
- Type: Text
- Identifier: http://hdl.handle.net/10962/31245 , vital:23928 , MS 10 801 , This manuscript is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
- Description: Programme outline for the South African Coloured National Convention, which took place in Claremont Civic Centre, Cape Town, from the 7th to the 10th of July 1961.
- Full Text:
- Date Issued: 1961
Suggestions: For consideration at Meeting of Preliminary Convention Committee, Cape Town: Monday 11th September, 1961
- Daniels, J C A, South African National Convention Movement. Council.
- Authors: Daniels, J C A , South African National Convention Movement. Council.
- Date: 1961-08-30
- Subjects: Coloured National Convention , Colored people (South Africa) , Civil rights -- South Africa , Apartheid -- South Africa , South Africa -- Race relations -- 20th century , South Africa -- Social conditions -- 1961-1994 , Human rights -- South Africa -- History -- 20th century , South Africa. South African Coloured National Convention , South Africa. South African Coloured People's Congress
- Type: Text
- Identifier: http://hdl.handle.net/10962/32082 , vital:24009 , MS 10 812 , This manuscript is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
- Description: Suggestions for consideration at the Meeting of Preliminary Convention Committee, placed before the Council of the South African National Convention Movement.
- Full Text:
- Date Issued: 1961-08-30
- Authors: Daniels, J C A , South African National Convention Movement. Council.
- Date: 1961-08-30
- Subjects: Coloured National Convention , Colored people (South Africa) , Civil rights -- South Africa , Apartheid -- South Africa , South Africa -- Race relations -- 20th century , South Africa -- Social conditions -- 1961-1994 , Human rights -- South Africa -- History -- 20th century , South Africa. South African Coloured National Convention , South Africa. South African Coloured People's Congress
- Type: Text
- Identifier: http://hdl.handle.net/10962/32082 , vital:24009 , MS 10 812 , This manuscript is held at the Cory Library for Humanities Research at Rhodes University. For further information contact cory@ru.ac.za. The digitisation of this image was made possible through a generous grant received from the Andrew W. Mellon Foundation 2014-2017.
- Description: Suggestions for consideration at the Meeting of Preliminary Convention Committee, placed before the Council of the South African National Convention Movement.
- Full Text:
- Date Issued: 1961-08-30
A class of ideals of the centre of a group ring
- Authors: O'Reilly, M F
- Date: 1981
- Language: English
- Type: Article
- Identifier: vital:6786 , http://hdl.handle.net/10962/d1006929
- Description: Reynolds (1972), using character-theory, showed that the p-section sums span an ideal of the centre Z(kG) of the group algebra of a finite group G over a field k of characteristic dividing the order of G. In O'Reilly (1973) a character-free proof was given. Here we extend these techniques to show the existence of a wider class of ideals of Z(kG).
- Full Text:
- Date Issued: 1981
- Authors: O'Reilly, M F
- Date: 1981
- Language: English
- Type: Article
- Identifier: vital:6786 , http://hdl.handle.net/10962/d1006929
- Description: Reynolds (1972), using character-theory, showed that the p-section sums span an ideal of the centre Z(kG) of the group algebra of a finite group G over a field k of characteristic dividing the order of G. In O'Reilly (1973) a character-free proof was given. Here we extend these techniques to show the existence of a wider class of ideals of Z(kG).
- Full Text:
- Date Issued: 1981
Tertiary phonolite volcanism in the Klinghardt Mountains of South West Africa/Namibia
- Authors: Marsh, Julian S , Lock, B E
- Date: 1981
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/133242 , vital:36953 , https://hdl.handle.net/10520/AJA10120750_2789
- Description: The Klinghardt Mountains in South West Africa (Namibia) were the site of an important volcanic outburst late in the Eocene or early in the Oligocene. Over a hundred endogenous domes and several lava flows of the coulee type were emplaced: all analysed samples (more than 60) comprise varieties of phonolite. A sequence of ash-flow tuffs of limited areal extent is present on Glasrucken.
- Full Text:
- Date Issued: 1981
- Authors: Marsh, Julian S , Lock, B E
- Date: 1981
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/133242 , vital:36953 , https://hdl.handle.net/10520/AJA10120750_2789
- Description: The Klinghardt Mountains in South West Africa (Namibia) were the site of an important volcanic outburst late in the Eocene or early in the Oligocene. Over a hundred endogenous domes and several lava flows of the coulee type were emplaced: all analysed samples (more than 60) comprise varieties of phonolite. A sequence of ash-flow tuffs of limited areal extent is present on Glasrucken.
- Full Text:
- Date Issued: 1981
Groote Schuur Hospital - General information on service conditions
- Authors: Trade Union Library
- Date: Dec 1982
- Subjects: Trade Union Library
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/118567 , vital:34646
- Full Text:
- Date Issued: Dec 1982
- Authors: Trade Union Library
- Date: Dec 1982
- Subjects: Trade Union Library
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/118567 , vital:34646
- Full Text:
- Date Issued: Dec 1982
Rhodes University East London Division : Commencement of academic year 1982
- Authors: Henderson, Derek Scott
- Date: 1982
- Language: English
- Type: text
- Identifier: vital:7572 , http://hdl.handle.net/10962/d1018449
- Full Text:
- Date Issued: 1982
- Authors: Henderson, Derek Scott
- Date: 1982
- Language: English
- Type: text
- Identifier: vital:7572 , http://hdl.handle.net/10962/d1018449
- Full Text:
- Date Issued: 1982
APDUSA Views
- Date: 1986-01
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/33033 , vital:32493 , Bulk File 7
- Description: APDUSA Views was published by the African People’s Democratic Union of Southern Africa (Natal), an affiliate of the New Unity Movement.
- Full Text: false
- Date Issued: 1986-01
- Date: 1986-01
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/33033 , vital:32493 , Bulk File 7
- Description: APDUSA Views was published by the African People’s Democratic Union of Southern Africa (Natal), an affiliate of the New Unity Movement.
- Full Text: false
- Date Issued: 1986-01
Vice-Chancellor's speech of welcome at the Symposium on Dam Safety Legislation : draft
- Authors: Henderson, Derek Scott
- Date: 1986
- Language: English
- Type: text
- Identifier: vital:7540 , http://hdl.handle.net/10962/d1018417
- Full Text:
- Date Issued: 1986
- Authors: Henderson, Derek Scott
- Date: 1986
- Language: English
- Type: text
- Identifier: vital:7540 , http://hdl.handle.net/10962/d1018417
- Full Text:
- Date Issued: 1986
The Ten-Point Programme of the New Unity Movement
- Date: 1987-01
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/33938 , vital:33131 , Bulk File 7
- Description: This is one of many individual publications put out by the New Unity Movement.
- Full Text: false
- Date Issued: 1987-01
- Date: 1987-01
- Subjects: Government, Resistance to -- South Africa , South Africa -- History -- 20th century , South Africa -- Politics and government
- Language: English
- Type: text , Article
- Identifier: http://hdl.handle.net/10948/33938 , vital:33131 , Bulk File 7
- Description: This is one of many individual publications put out by the New Unity Movement.
- Full Text: false
- Date Issued: 1987-01
A new species of Pogonophryne (Pisces, Artedidraconidae) from Queen Maud Land, Antarctica
- Eakin, Richard R, 1946-, J.L.B. Smith Institute of Ichthyology
- Authors: Eakin, Richard R, 1946- , J.L.B. Smith Institute of Ichthyology
- Date: 1988-01
- Subjects: Pogonophryne -- Antarctica -- Queen Maud Land
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/70280 , vital:29641 , Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB)) Periodicals Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB))
- Description: Online version of original print edition of the Special Publication of the J.L.B. Smith Institute of Ichthyology; No. 45 , Pogonophryne platypogon is described from a 61.0 mm SL juvenile specimen collected near Queen Maud Land, Antarctica. This species belongs to the dorsally spotted group of Pogonophryne but is distinguished from other known species of the group in having a smoothly flattened terminal expansion on the mental barbel and a very narrow snout and jaws (jaw width less than 13% SL). It also has a very narrow interorbital region (less than 5% SL).
- Full Text:
- Date Issued: 1988-01
- Authors: Eakin, Richard R, 1946- , J.L.B. Smith Institute of Ichthyology
- Date: 1988-01
- Subjects: Pogonophryne -- Antarctica -- Queen Maud Land
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/70280 , vital:29641 , Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB)) Periodicals Margaret Smith Library (South African Institute for Aquatic Biodiversity (SAIAB))
- Description: Online version of original print edition of the Special Publication of the J.L.B. Smith Institute of Ichthyology; No. 45 , Pogonophryne platypogon is described from a 61.0 mm SL juvenile specimen collected near Queen Maud Land, Antarctica. This species belongs to the dorsally spotted group of Pogonophryne but is distinguished from other known species of the group in having a smoothly flattened terminal expansion on the mental barbel and a very narrow snout and jaws (jaw width less than 13% SL). It also has a very narrow interorbital region (less than 5% SL).
- Full Text:
- Date Issued: 1988-01
A possible relation between dietary zinc and cAMP in the regulation of tumour cell proliferation in the rat
- Skeef, Noel S, Duncan, John R
- Authors: Skeef, Noel S , Duncan, John R
- Date: 1988
- Language: English
- Type: Article
- Identifier: vital:6473 , http://hdl.handle.net/10962/d1006154 , http://dx.doi.org/10.1079/BJN19880052
- Description: The possibility of an effect of zinc on the rate of tumour cell division, mediated through a regulation of cellular cAMP concentration, was investigated in the present study in rats. Dietary Zn deficiency (< 1·5 mg Zn/kg) but not Zn excess (500 mg Zn/kg) resulted in an increased cAMP concentration in transplanted hepatoma cells. Neither treatment had any effect on the cAMP concentration in regenerating liver or normal resting liver. Both the deficient and excess Zn diets resulted in a small reduction in tumour growth (not statistically significant). The results seem to indicate that the relation investigated in the present study does not apply in the cell line used.
- Full Text:
- Date Issued: 1988
- Authors: Skeef, Noel S , Duncan, John R
- Date: 1988
- Language: English
- Type: Article
- Identifier: vital:6473 , http://hdl.handle.net/10962/d1006154 , http://dx.doi.org/10.1079/BJN19880052
- Description: The possibility of an effect of zinc on the rate of tumour cell division, mediated through a regulation of cellular cAMP concentration, was investigated in the present study in rats. Dietary Zn deficiency (< 1·5 mg Zn/kg) but not Zn excess (500 mg Zn/kg) resulted in an increased cAMP concentration in transplanted hepatoma cells. Neither treatment had any effect on the cAMP concentration in regenerating liver or normal resting liver. Both the deficient and excess Zn diets resulted in a small reduction in tumour growth (not statistically significant). The results seem to indicate that the relation investigated in the present study does not apply in the cell line used.
- Full Text:
- Date Issued: 1988
POTWA Newsletter - Northern Cape Congress
- Post and Telecommunication Workers Association (POTWA)
- Authors: Post and Telecommunication Workers Association (POTWA)
- Date: 1989
- Subjects: POTWA
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/162032 , vital:40750
- Description: The Northern Cape Region of Potwa held a very vibrant regional congress in Vryburg on the 15 & 16 April 1989. The Congress was characterised by a spirit of comradely self-criticism. This political maturity of the comrades went as far as to give a proper critical analysis of the structures of our organisation. The analysis accepted that the functioning of some of our organisation’s structures is not up to standard. The congress also noted that the participation of the general membership in the activities of the organisation is not satisfactory. As it is typical of matured comrades, the congress realised that such problems are not peculiar to Potwa. Shortcomings such as these are indicative of a huge and growing organisation. Because of this, the comrades explored ways and means of solving these problems. The congress concluded that the opening of a regional office combined with effective usage of our Potwa newsletter would go a long way in solving some of our problems.
- Full Text:
- Date Issued: 1989
- Authors: Post and Telecommunication Workers Association (POTWA)
- Date: 1989
- Subjects: POTWA
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10962/162032 , vital:40750
- Description: The Northern Cape Region of Potwa held a very vibrant regional congress in Vryburg on the 15 & 16 April 1989. The Congress was characterised by a spirit of comradely self-criticism. This political maturity of the comrades went as far as to give a proper critical analysis of the structures of our organisation. The analysis accepted that the functioning of some of our organisation’s structures is not up to standard. The congress also noted that the participation of the general membership in the activities of the organisation is not satisfactory. As it is typical of matured comrades, the congress realised that such problems are not peculiar to Potwa. Shortcomings such as these are indicative of a huge and growing organisation. Because of this, the comrades explored ways and means of solving these problems. The congress concluded that the opening of a regional office combined with effective usage of our Potwa newsletter would go a long way in solving some of our problems.
- Full Text:
- Date Issued: 1989
Role of agricultural marketing in transforming subsistence agriculture: African Case Study
- Antrobus, Geoffrey G, Fraser, Gavin C G
- Authors: Antrobus, Geoffrey G , Fraser, Gavin C G
- Date: 1989
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/143112 , vital:38202 , https://ageconsearch.umn.edu/record/197714/
- Description: A lack of agricultural marketing facilities is generally seen as one of the major obstacles to agricultural development. However, subsistence producers in southern Africa are influenced by certain exogeneous factors, such as competition from commercial production, the well-developed marketing system, and off-farm employment opportunities in South Africa. This paper studies the effect of the institution of an organized marketing system in Ciskei on the level of agricultural production. This is found to have had no significant effect because the majority of the able-bodied males are working in the metropolitan areas of South Africa. This has resulted in agriculture becoming a part-time supplementary activity for women, old men, and children in the rural areas.
- Full Text:
- Date Issued: 1989
- Authors: Antrobus, Geoffrey G , Fraser, Gavin C G
- Date: 1989
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/143112 , vital:38202 , https://ageconsearch.umn.edu/record/197714/
- Description: A lack of agricultural marketing facilities is generally seen as one of the major obstacles to agricultural development. However, subsistence producers in southern Africa are influenced by certain exogeneous factors, such as competition from commercial production, the well-developed marketing system, and off-farm employment opportunities in South Africa. This paper studies the effect of the institution of an organized marketing system in Ciskei on the level of agricultural production. This is found to have had no significant effect because the majority of the able-bodied males are working in the metropolitan areas of South Africa. This has resulted in agriculture becoming a part-time supplementary activity for women, old men, and children in the rural areas.
- Full Text:
- Date Issued: 1989
REE fractionation and Ce anomalies in weathered Karoo dolerite
- Authors: Marsh, Julian S
- Date: 1991
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/145819 , vital:38469 , https://doi.org/10.1016/0009-2541(91)90099-D
- Description: Analyses of samples from a weathering profile on Karoo dolerite allow elements to be divided into three groups depending on their behaviour. Si, K, Na, Mg, Ca, Sr, Ba and V are mobilized and removed from weathered products. Fe, Al. Ti, Zr, Hf, Zn, Cu, Sc, Co and Ni are immobile. REE, Y, and to a lesser extent Cr, are mobile and redistributed within the profile without a net loss of these elements from the profile. Large positive Ce anomalies are developed in oxidized weathered products by preferential leaching of the other REE's. Negative Ce anomalies and REE enrichment is a feature of less altered dolerite.
- Full Text: false
- Date Issued: 1991
- Authors: Marsh, Julian S
- Date: 1991
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/145819 , vital:38469 , https://doi.org/10.1016/0009-2541(91)90099-D
- Description: Analyses of samples from a weathering profile on Karoo dolerite allow elements to be divided into three groups depending on their behaviour. Si, K, Na, Mg, Ca, Sr, Ba and V are mobilized and removed from weathered products. Fe, Al. Ti, Zr, Hf, Zn, Cu, Sc, Co and Ni are immobile. REE, Y, and to a lesser extent Cr, are mobile and redistributed within the profile without a net loss of these elements from the profile. Large positive Ce anomalies are developed in oxidized weathered products by preferential leaching of the other REE's. Negative Ce anomalies and REE enrichment is a feature of less altered dolerite.
- Full Text: false
- Date Issued: 1991
Influence of the oil phase dispersion in a cream base on the in vivo release of betamethasone 17-valerate
- Haigh, J M, Smith, E W, Meyer, E, Fassihi, A R
- Authors: Haigh, J M , Smith, E W , Meyer, E , Fassihi, A R
- Date: 1992
- Language: English
- Type: Article
- Identifier: vital:6365 , http://hdl.handle.net/10962/d1006065
- Description: Release of betamethasone valerate (betamethasone 17-valerate) from 3 extemporaneous cream formulations (1 control, 1 containing propylene glycol, and 1 containing \b/-cyclodextrin) and a commercial cream formulation (Betnovate) was compared using the human skin blanching assay in 12 healthy male volunteers. All 3 extemporaneous formulations showed similar drug release rates, equivalent to or better than the commercial preparation containing betamethasone in a 10 fold higher concentration. Electron microscopic examination showed considerably finer dispersion of the oil phase in the extemporaneous formulations. It was concluded that the increased surface area available for partitioning of betamethasone between the cream and the skin is responsible for the improved topical availability of the drug from the extemporaneous formulations.
- Full Text: false
- Date Issued: 1992
- Authors: Haigh, J M , Smith, E W , Meyer, E , Fassihi, A R
- Date: 1992
- Language: English
- Type: Article
- Identifier: vital:6365 , http://hdl.handle.net/10962/d1006065
- Description: Release of betamethasone valerate (betamethasone 17-valerate) from 3 extemporaneous cream formulations (1 control, 1 containing propylene glycol, and 1 containing \b/-cyclodextrin) and a commercial cream formulation (Betnovate) was compared using the human skin blanching assay in 12 healthy male volunteers. All 3 extemporaneous formulations showed similar drug release rates, equivalent to or better than the commercial preparation containing betamethasone in a 10 fold higher concentration. Electron microscopic examination showed considerably finer dispersion of the oil phase in the extemporaneous formulations. It was concluded that the increased surface area available for partitioning of betamethasone between the cream and the skin is responsible for the improved topical availability of the drug from the extemporaneous formulations.
- Full Text: false
- Date Issued: 1992
Introduction and extinction of brown trout (Salmo trutta L.) in an impoverished subantarctic stream
- Cooper, J, Crafford, J E, Hecht, Thomas
- Authors: Cooper, J , Crafford, J E , Hecht, Thomas
- Date: 1992
- Subjects: Anadromous fishes -- Marion Island
- Language: English
- Type: Article
- Identifier: vital:6767 , http://hdl.handle.net/10962/d1008044
- Description: Brown trout were introduced to the Van den Boogaard River on subantarctic Marion Island in 1964, and a small population became established. The last individual was seen in 1984, and the species is now considered to be extinct on the island. Their diet was exclusively allochthonous, with snails and spiders predominating. Ages estimated at six to eleven years showed that spawning must have occurred since the original introduction. Since the Van den Boogaard River enters the sea via a waterfall, it is postulated that trout were not able to practice an anadromous life-style, and that this, as well as other factors connected with the impoverished nature of the stream, led to dwarfing of the resident population. No further introductions of alien fish to Marion Island should be contemplated.
- Full Text:
- Date Issued: 1992
- Authors: Cooper, J , Crafford, J E , Hecht, Thomas
- Date: 1992
- Subjects: Anadromous fishes -- Marion Island
- Language: English
- Type: Article
- Identifier: vital:6767 , http://hdl.handle.net/10962/d1008044
- Description: Brown trout were introduced to the Van den Boogaard River on subantarctic Marion Island in 1964, and a small population became established. The last individual was seen in 1984, and the species is now considered to be extinct on the island. Their diet was exclusively allochthonous, with snails and spiders predominating. Ages estimated at six to eleven years showed that spawning must have occurred since the original introduction. Since the Van den Boogaard River enters the sea via a waterfall, it is postulated that trout were not able to practice an anadromous life-style, and that this, as well as other factors connected with the impoverished nature of the stream, led to dwarfing of the resident population. No further introductions of alien fish to Marion Island should be contemplated.
- Full Text:
- Date Issued: 1992