To investigate the effect of a change in hard gelatin capsule supplier on a phenytoin sodium capsule formulation
- Authors: Marx, Amor
- Date: 2004
- Subjects: Capsules (Pharmacy) , Phenytoin
- Language: English
- Type: Thesis , Masters , MTech (Chemistry)
- Identifier: vital:10984 , http://hdl.handle.net/10948/265 , Capsules (Pharmacy) , Phenytoin
- Description: Stability studies were undertaken at ambient (25ºC/60%RH) and accelerated conditions (40ºC/75%RH) to determine the effect of changing of hard gelatin capsule supplier on a phenytoin sodium (100 mg) capsule formulation. Three hard gelatin capsule suppliers: RP Scherer (Supplier A), Capsugel (supplier B) and Associated Caps (Supplier C) were used in the study. Capsules were analyzed just after filling of the capsules (T0), after 1 month (T1), after 2 months (T2) and after 3 months (T3) after being stored in securitainers under the above-mentioned conditions. The moisture content of the empty shells as well as the capsule contents were analysed at each time-point. The capsule disintegration time was recorded at each time point. Multi-point dissolution testing was performed at each time point to determine the release of the active substance in each case. Based on the achieved results, the best capsule shell supplier was recommended, and other suggestions were made to improve the capsule formulation.
- Full Text:
- Date Issued: 2004
- Authors: Marx, Amor
- Date: 2004
- Subjects: Capsules (Pharmacy) , Phenytoin
- Language: English
- Type: Thesis , Masters , MTech (Chemistry)
- Identifier: vital:10984 , http://hdl.handle.net/10948/265 , Capsules (Pharmacy) , Phenytoin
- Description: Stability studies were undertaken at ambient (25ºC/60%RH) and accelerated conditions (40ºC/75%RH) to determine the effect of changing of hard gelatin capsule supplier on a phenytoin sodium (100 mg) capsule formulation. Three hard gelatin capsule suppliers: RP Scherer (Supplier A), Capsugel (supplier B) and Associated Caps (Supplier C) were used in the study. Capsules were analyzed just after filling of the capsules (T0), after 1 month (T1), after 2 months (T2) and after 3 months (T3) after being stored in securitainers under the above-mentioned conditions. The moisture content of the empty shells as well as the capsule contents were analysed at each time-point. The capsule disintegration time was recorded at each time point. Multi-point dissolution testing was performed at each time point to determine the release of the active substance in each case. Based on the achieved results, the best capsule shell supplier was recommended, and other suggestions were made to improve the capsule formulation.
- Full Text:
- Date Issued: 2004
Betwixt and between: exploring the passage of liminal space
- Authors: Key, Michelle
- Date: 2005
- Subjects: Bourgeois, Louis, 1911- Spider , Art and anthropology , Art criticism , Liminality
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2406 , http://hdl.handle.net/10962/d1002202 , Bourgeois, Louis, 1911- Spider , Art and anthropology , Art criticism , Liminality
- Description: The focus of this thesis is on the liminal space, limen being Latin for threshold. The liminal space is used as a means of figuring and reading artworks that appear to be in a process of becoming and disappearing. A dialectical and reciprocal reading is made of Bourgeois’ “neo-Baroque” artwork Spider (1997) and Michelle Key’s Betwixt-in-Between (2004). Liminality here is discussed within the theoretical framework of several key conceptual concerns, including abjection (as examined principally by Julia Kristeva), Baroque thought (as discussed by Mieke Bal, Gilles Deleuze, Jacques Lacan and Slavoj Žižek) and allegory (as figured primarily by Walter Benjamin and commentators on Benjamin’s writings). What links these concerns are their focus on indeterminacy, instability, and process as opposed to certitude and finitude. The exploration of the inscription of time in space; that is the temporal process, which gives rise to, which produces, the spatial dimension, is attempted in order to make meaning, however provisionally, of what may be argued to destabilise meaning and to consider possibilities for both art-making and interpretation that would engage critically with this instability.
- Full Text:
- Date Issued: 2005
- Authors: Key, Michelle
- Date: 2005
- Subjects: Bourgeois, Louis, 1911- Spider , Art and anthropology , Art criticism , Liminality
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2406 , http://hdl.handle.net/10962/d1002202 , Bourgeois, Louis, 1911- Spider , Art and anthropology , Art criticism , Liminality
- Description: The focus of this thesis is on the liminal space, limen being Latin for threshold. The liminal space is used as a means of figuring and reading artworks that appear to be in a process of becoming and disappearing. A dialectical and reciprocal reading is made of Bourgeois’ “neo-Baroque” artwork Spider (1997) and Michelle Key’s Betwixt-in-Between (2004). Liminality here is discussed within the theoretical framework of several key conceptual concerns, including abjection (as examined principally by Julia Kristeva), Baroque thought (as discussed by Mieke Bal, Gilles Deleuze, Jacques Lacan and Slavoj Žižek) and allegory (as figured primarily by Walter Benjamin and commentators on Benjamin’s writings). What links these concerns are their focus on indeterminacy, instability, and process as opposed to certitude and finitude. The exploration of the inscription of time in space; that is the temporal process, which gives rise to, which produces, the spatial dimension, is attempted in order to make meaning, however provisionally, of what may be argued to destabilise meaning and to consider possibilities for both art-making and interpretation that would engage critically with this instability.
- Full Text:
- Date Issued: 2005
Beyond black and white: black solidarity in post-apartheid South Africa
- Authors: Majavu, Phumlani
- Date: 2014
- Subjects: Black nationalism -- South Africa , Race relations -- South Africa , South Africa -- Politics and government -- 21st century
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2887 , http://hdl.handle.net/10962/d1016359
- Description: Almost 20 years after the white Nationalist government was voted out, some black South Africans believe that black solidarity is still necessary in South Africa. These people argue that since post-apartheid South Africa is still marred with racial injustice, it makes sense for blacks to advocate for black solidarity. Although it is true that black solidarity played an important role in the struggle against apartheid, in this thesis I argue that the struggle against current forms of racial injustice does not necessarily require black solidarity. This is not to deny the prevailing racialized oppression in the post-apartheid era, nor to deny the importance of black solidarity in the past; rather the point I am making is that the current form of racial oppression is somewhat different from the one before 1994. Hence I argue in this thesis that the current form of racial oppression requires us to do certain things differently. Doing things differently means improving upon the strategies of the past. For this to happen, I argue that every human being who believes in and is committed to racial justice ought to be included in the struggle for justice. Change, after all, is brought about when committed human beings work together for liberation and justice.
- Full Text:
- Date Issued: 2014
- Authors: Majavu, Phumlani
- Date: 2014
- Subjects: Black nationalism -- South Africa , Race relations -- South Africa , South Africa -- Politics and government -- 21st century
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2887 , http://hdl.handle.net/10962/d1016359
- Description: Almost 20 years after the white Nationalist government was voted out, some black South Africans believe that black solidarity is still necessary in South Africa. These people argue that since post-apartheid South Africa is still marred with racial injustice, it makes sense for blacks to advocate for black solidarity. Although it is true that black solidarity played an important role in the struggle against apartheid, in this thesis I argue that the struggle against current forms of racial injustice does not necessarily require black solidarity. This is not to deny the prevailing racialized oppression in the post-apartheid era, nor to deny the importance of black solidarity in the past; rather the point I am making is that the current form of racial oppression is somewhat different from the one before 1994. Hence I argue in this thesis that the current form of racial oppression requires us to do certain things differently. Doing things differently means improving upon the strategies of the past. For this to happen, I argue that every human being who believes in and is committed to racial justice ought to be included in the struggle for justice. Change, after all, is brought about when committed human beings work together for liberation and justice.
- Full Text:
- Date Issued: 2014
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