Hop depletion reduces HSF1 levels and activity and coincides with reduced stress resilience:
- Chakraborty, Abantika, Edkins, Adrienne L
- Authors: Chakraborty, Abantika , Edkins, Adrienne L
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165440 , vital:41244 , https://doi.org/10.1016/j.bbrc.2020.04.072
- Description: Heat-shock factor 1 (HSF1) regulates the transcriptional response to stress and controls expression of molecular chaperones required for cell survival. Here we report that HSF1 is regulated by the abundance of the Hsp70-Hsp90 organizing protein (Hop/STIP1).
- Full Text:
- Date Issued: 2020
- Authors: Chakraborty, Abantika , Edkins, Adrienne L
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165440 , vital:41244 , https://doi.org/10.1016/j.bbrc.2020.04.072
- Description: Heat-shock factor 1 (HSF1) regulates the transcriptional response to stress and controls expression of molecular chaperones required for cell survival. Here we report that HSF1 is regulated by the abundance of the Hsp70-Hsp90 organizing protein (Hop/STIP1).
- Full Text:
- Date Issued: 2020
Acceptance of ambulatory blood pressure monitoring in a semi-rural population in South Africa:
- Chiwanza, Farisai, Irwin, Yoland, Dowse, Roslind
- Authors: Chiwanza, Farisai , Irwin, Yoland , Dowse, Roslind
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157072 , vital:40084 , DOI: https://doi.org/10.4102/hsag.v25i0.1336
- Description: Ambulatory blood pressure monitoring is a valuable tool that helps in providing an insight into the diagnosis and management of hypertension; however, no evidence exists of its acceptance in the diverse South African population. We assessed the acceptance of an ambulatory blood pressure monitor in patients attending public sector primary health care (PHC) clinics. Five PHC clinics in the Makana subdistrict in the Eastern Cape.
- Full Text:
- Date Issued: 2020
- Authors: Chiwanza, Farisai , Irwin, Yoland , Dowse, Roslind
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/157072 , vital:40084 , DOI: https://doi.org/10.4102/hsag.v25i0.1336
- Description: Ambulatory blood pressure monitoring is a valuable tool that helps in providing an insight into the diagnosis and management of hypertension; however, no evidence exists of its acceptance in the diverse South African population. We assessed the acceptance of an ambulatory blood pressure monitor in patients attending public sector primary health care (PHC) clinics. Five PHC clinics in the Makana subdistrict in the Eastern Cape.
- Full Text:
- Date Issued: 2020
Non-aggregated lipophilic water-soluble tin porphyrins as photosensitizers for photodynamic therapy and photodynamic antimicrobial chemotherapy:
- Babu, Balaji, Soy, Rodah C, Mack, John, Nyokong, Tebello
- Authors: Babu, Balaji , Soy, Rodah C , Mack, John , Nyokong, Tebello
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158241 , vital:40165 , DOI: 10.1039/d0nj01564d
- Description: Two readily synthesized water-soluble Sn(IV) porphyrins have been prepared with quaternized pyridyl nitrogens and 2-naphthalato trans-axial ligands. Methyl and hexyl groups were attached to the quaternized nitrogens to form lipophilic dyes with high singlet oxygen quantum yields (ca. 0.90) and unusually long triplet state lifetimes. The dyes exhibit good photodynamic activity against MCF-7 cells with IC50 values of 14.3 and 8.5 μM, respectively. The hexyl quaternized dye exhibited a 9.69 log reduction value (0.5 μM) towards S. aureus under illumination for 90 min (250 mW cm−2). The results demonstrate that this set of structural modification strategies for photosensitizer dyes merits further in depth study.
- Full Text:
- Date Issued: 2020
- Authors: Babu, Balaji , Soy, Rodah C , Mack, John , Nyokong, Tebello
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/158241 , vital:40165 , DOI: 10.1039/d0nj01564d
- Description: Two readily synthesized water-soluble Sn(IV) porphyrins have been prepared with quaternized pyridyl nitrogens and 2-naphthalato trans-axial ligands. Methyl and hexyl groups were attached to the quaternized nitrogens to form lipophilic dyes with high singlet oxygen quantum yields (ca. 0.90) and unusually long triplet state lifetimes. The dyes exhibit good photodynamic activity against MCF-7 cells with IC50 values of 14.3 and 8.5 μM, respectively. The hexyl quaternized dye exhibited a 9.69 log reduction value (0.5 μM) towards S. aureus under illumination for 90 min (250 mW cm−2). The results demonstrate that this set of structural modification strategies for photosensitizer dyes merits further in depth study.
- Full Text:
- Date Issued: 2020
Compounds isolation and biological activities of Piptadeniastrum africanum (hook. f.) Brennan (Fabaceae) roots:
- Teinkela, Jean E M, Noundou, Xavier S, Mimba, Jeanne E Z, Meyer, Franck, Tabouguia, Octavie M, Nguedia, Jules C A, Hoppe, Heinrich C, Krause, Rui W M, Wintjens, René, Azebaze, Anatole G B
- Authors: Teinkela, Jean E M , Noundou, Xavier S , Mimba, Jeanne E Z , Meyer, Franck , Tabouguia, Octavie M , Nguedia, Jules C A , Hoppe, Heinrich C , Krause, Rui W M , Wintjens, René , Azebaze, Anatole G B
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150084 , vital:38938 , https://doi.org/10.1016/j.jep.2020.112716
- Description: The dicotyledonous plant Piptadeniastrum africanum (hook.f.) Brennan (Fabaceae) is used in traditional medicine to treat various human complaints including bronchitis, coughing, urino-genital ailments, meningitis, abdominal pain, treatment of wounds, malaria and gastrointestinal ailments, and is used as a purgative and worm expeller. The present study describes the phytochemical investigation and the determination of the antimicrobial, antiplasmodial and antitrypanosomal activities of crude extract, fractions and compounds extracted from Piptadeniastrum africanum roots.
- Full Text:
- Date Issued: 2020
- Authors: Teinkela, Jean E M , Noundou, Xavier S , Mimba, Jeanne E Z , Meyer, Franck , Tabouguia, Octavie M , Nguedia, Jules C A , Hoppe, Heinrich C , Krause, Rui W M , Wintjens, René , Azebaze, Anatole G B
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150084 , vital:38938 , https://doi.org/10.1016/j.jep.2020.112716
- Description: The dicotyledonous plant Piptadeniastrum africanum (hook.f.) Brennan (Fabaceae) is used in traditional medicine to treat various human complaints including bronchitis, coughing, urino-genital ailments, meningitis, abdominal pain, treatment of wounds, malaria and gastrointestinal ailments, and is used as a purgative and worm expeller. The present study describes the phytochemical investigation and the determination of the antimicrobial, antiplasmodial and antitrypanosomal activities of crude extract, fractions and compounds extracted from Piptadeniastrum africanum roots.
- Full Text:
- Date Issued: 2020
Bioelectrocatalysis and surface analysis of gold coated with nickel oxide/hydroxide and glucose oxidase towards detection of glucose:
- Njoko, Nqobile, Louzada, Marcel, Britton, Jonathan, Khene, Samson M, Nyokong, Tebello, Mashazi, Philani N
- Authors: Njoko, Nqobile , Louzada, Marcel , Britton, Jonathan , Khene, Samson M , Nyokong, Tebello , Mashazi, Philani N
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150071 , vital:38937 , https://doi.org/10.1016/j.colsurfb.2020.110981
- Description: The fabricating of metal oxide thin films onto conducting surfaces continues to grow and their potential applications as surfaces for biosensor applications is of paramount importance. The correct orientation of glucose oxidase redox enzymes yields very important biointerfaces capable of selectively detecting D-glucose as a measure of blood sugar for healthy and diabetic sick patients. The electrodeposition of redox enzymes, such as glucose oxidase enzymes, onto gold electrode surfaces pre-modified with nickel oxide was investigated in this work.
- Full Text:
- Date Issued: 2020
- Authors: Njoko, Nqobile , Louzada, Marcel , Britton, Jonathan , Khene, Samson M , Nyokong, Tebello , Mashazi, Philani N
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/150071 , vital:38937 , https://doi.org/10.1016/j.colsurfb.2020.110981
- Description: The fabricating of metal oxide thin films onto conducting surfaces continues to grow and their potential applications as surfaces for biosensor applications is of paramount importance. The correct orientation of glucose oxidase redox enzymes yields very important biointerfaces capable of selectively detecting D-glucose as a measure of blood sugar for healthy and diabetic sick patients. The electrodeposition of redox enzymes, such as glucose oxidase enzymes, onto gold electrode surfaces pre-modified with nickel oxide was investigated in this work.
- Full Text:
- Date Issued: 2020
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