- Title
- LIPOPROTEINS AND THEIR SUBFRACTIONS IN TYPE 2 DIABETES PATIENTS FROM MTHATHA, EASTERN CAPE, SOUTH AFRICA
- Creator
- JIM JOSEPH THYTHARAYIL
- Subject
- Biochemistry
- Date
- 2017
- Type
- Thesis, Doctoral
- Identifier
- http://hdl.handle.net/11260/2116
- Identifier
- vital:40897
- Description
- Cardiovascular disease is the main cause of mortality in diabetic patients and the risk of mortality due to cardiovascular disease is 2-4 times higher in diabetic patients when compared to the general population. The dysregulation of lipid metabolism due to abnormal insulin concentration or activity is one of the major reasons for the increased cardiovascular risk associated with diabetes. The main objective of the study was to analyse the alterations in the sub-fractions of lipoproteins in type 2 diabetic patients from hospitals and clinics around Mthatha. The results of the study showed that the concentration of small dense low density lipoproteins (LDL) was highly elevated in the diabetic patients with diabetic patients having four times the odds of having a pattern of increased small dense LDL than people without diabetes. The diabetic patients also had a very high concentration of oxidized low-density lipoprotein and lipoprotein (a). These alterations in lipid concentration exposed the diabetic patients to high risk of cardiovascular disease. This atherogenic alteration in lipid concentration could not be detected by the traditional lipid profile and hence analysis of lipoprotein sub-fractions can help in better management and decrease cardiovascular events in diabetic patients.
- Format
- Publisher
- Walter Sisulu University: Faculty of Health Sciences
- Language
- English
- Rights
- Walter Sisulu University
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Collections
WSU Department of Laboratory medicine and Pathology
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Jim Joseph Tythara.pdf | 94 KB | Adobe Acrobat PDF | View Details Download |