- Title
- Pharmacokinetics of cyclizine following intravenous administration to human volunteers
- Creator
- Kanfer, Isadore
- Creator
- Walker, Roderick B
- Subject
- To be catalogued
- Date Issued
- 1996
- Date
- 1996
- Type
- text
- Type
- article
- Identifier
- http://hdl.handle.net/10962/184389
- Identifier
- vital:44214
- Identifier
- xlink:href="https://doi.org/10.1016/0928-0987(96)00177-7"
- Description
- The pharmacokinetics of cyclizine, a piperazine derivative useful in the prevention and treatment of nausea and vomiting, was investigated in six healthy male volunteers following an intravenous bolus dose. The drug is extensively distributed with a mean volume of distribution of 16.50 ± 3.33 l/kg and a mean total clearance of 0.870 ± 0.105 l/h per kg. Urinary excretion data showed that less than one percent of the dose was excreted up to 36 h as unchanged drug in the urine. The extremely low mean renal clearance (0.005 ± 0.002 l/h per kg) for the parent drug comprised only a small proportion of total clearance indicating that urinary excretion of parent drug is not a major route of elimination for cyclizine. The drug appears to exhibit biexponential pharmacokinetics and has a terminal elimination half-life of approximately 13 h.
- Format
- computer
- Format
- online resource
- Format
- application/pdf
- Format
- 1 online resource (6 pages)
- Format
- Publisher
- Elsevier
- Language
- English
- Relation
- European Journal of Pharmaceutical Sciences
- Relation
- Walker, R.B. and Kanfer, I., 1996. Pharmacokinetics of cyclizine following intravenous administration to human volunteers. European journal of pharmaceutical sciences, 4(5), pp.301-306
- Relation
- European Journal of Pharmaceutical Sciences volume 4 number 5 p. 301 1996 0928-0987
- Rights
- Publisher
- Rights
- Use of this resource is governed by the terms and conditions of the Elsevier Terms and Conditions Statement (https://www.elsevier.com/legal/elsevier-website-terms-and-conditions)
- Rights
- Closed Access
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Collections
Walker, Roderick Bryan (Prof)
Kanfer, Isadore (Prof)
RU Department of Pharmacy
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | SOURCE1 | Pharmacokinetics of cyclizine following intravenous administration to human volunteers.pdf | 731 KB | Adobe Acrobat PDF | View Details Download |