A preliminary investigation into the patterns of performance on a computerized adaptive test battery implications for admissions and placement
- Authors: Vorster, Marlene
- Date: 2002
- Subjects: Universities and colleges -- Admission , Advanced placement programs (Education) , Computer adaptive testing , Universities and colleges -- Entrance requirements
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:11030 , http://hdl.handle.net/10948/285 , Universities and colleges -- Admission , Advanced placement programs (Education) , Computer adaptive testing , Universities and colleges -- Entrance requirements
- Description: The fallibility of human judgment in the making of decisions requires the use of tests to enhance decision-making processes. Although testing is surrounded with issues of bias and fairness, it remains the best means of facilitating decisions over more subjective alternatives. As a country in transition, all facets of South African society are being transformed. The changes taking place within the tertiary education system to redress the legacy of Apartheid, coincide with an international trend of transforming higher education. One important area that is being transformed relates to university entrance requirements and admissions procedures. In South Africa, these were traditionally based on matriculation performance, which has been found to be a more variable predictor of academic success for historically disadvantaged students. Alternative or revised admissions procedures have been implemented at universities throughout the country, in conjunction with academic development programmes. However, it is argued in this dissertation that a paradigm shift is necessary to conceptualise admissions and placement assessment in a developmentally oriented way. Furthermore, it is motivated that it is important to keep abreast of advances in theory, such as item response theory (IRT) and technology, such as computerized adaptive testing (CAT), in test development to enhance the effectiveness of selecting and placing learners in tertiary programmes. This study focuses on investigating the use of the Accuplacer Computerized Placement Tests (CPTs), an adaptive test battery that was developed in the USA, to facilitate unbiased and fair admissions, placement and development decisions in the transforming South African context. The battery has been implemented at a university in the Eastern Cape and its usefulness was investigated for 193 participants, divided into two groups of degree programmes, depending on whether or not admission to the degree required mathematics as a matriculation subject. Mathematics based degree programme learners (n = 125) wrote three and non-mathematics based degree programme learners (n = 68) wrote two tests of the Accuplacer test battery. Correlations were computed between the Accuplacer scores and matriculation performance, and between the Accuplacer scores, matriculation performance and academic results. All yielded significant positive relationships excepting for the one subtest of the Accuplacer with academic performance for the non-mathematics based degree group. Multiple correlations for both groups indicated that the Accuplacer scores and matriculation results contribute unique information about academic performance. Cluster analysis for both groups yielded three underlying patterns of performance in the data sets. An attempt was made to validate the cluster groups internally through a MANOVA and single-factor ANOVAs. It was found that Accuplacer subtests and matriculation results do discriminate to an extent among clusters of learners in both groups of degree programmes investigated. Clusters were described in terms of demographic information and it was determined that the factors of culture and home language and how they relate to cluster group membership need further investigation. The main suggestion flowing from these findings is that an attempt be made to confirm the results with a larger sample size and for different cultural and language groups.
- Full Text:
- Date Issued: 2002
- Authors: Vorster, Marlene
- Date: 2002
- Subjects: Universities and colleges -- Admission , Advanced placement programs (Education) , Computer adaptive testing , Universities and colleges -- Entrance requirements
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:11030 , http://hdl.handle.net/10948/285 , Universities and colleges -- Admission , Advanced placement programs (Education) , Computer adaptive testing , Universities and colleges -- Entrance requirements
- Description: The fallibility of human judgment in the making of decisions requires the use of tests to enhance decision-making processes. Although testing is surrounded with issues of bias and fairness, it remains the best means of facilitating decisions over more subjective alternatives. As a country in transition, all facets of South African society are being transformed. The changes taking place within the tertiary education system to redress the legacy of Apartheid, coincide with an international trend of transforming higher education. One important area that is being transformed relates to university entrance requirements and admissions procedures. In South Africa, these were traditionally based on matriculation performance, which has been found to be a more variable predictor of academic success for historically disadvantaged students. Alternative or revised admissions procedures have been implemented at universities throughout the country, in conjunction with academic development programmes. However, it is argued in this dissertation that a paradigm shift is necessary to conceptualise admissions and placement assessment in a developmentally oriented way. Furthermore, it is motivated that it is important to keep abreast of advances in theory, such as item response theory (IRT) and technology, such as computerized adaptive testing (CAT), in test development to enhance the effectiveness of selecting and placing learners in tertiary programmes. This study focuses on investigating the use of the Accuplacer Computerized Placement Tests (CPTs), an adaptive test battery that was developed in the USA, to facilitate unbiased and fair admissions, placement and development decisions in the transforming South African context. The battery has been implemented at a university in the Eastern Cape and its usefulness was investigated for 193 participants, divided into two groups of degree programmes, depending on whether or not admission to the degree required mathematics as a matriculation subject. Mathematics based degree programme learners (n = 125) wrote three and non-mathematics based degree programme learners (n = 68) wrote two tests of the Accuplacer test battery. Correlations were computed between the Accuplacer scores and matriculation performance, and between the Accuplacer scores, matriculation performance and academic results. All yielded significant positive relationships excepting for the one subtest of the Accuplacer with academic performance for the non-mathematics based degree group. Multiple correlations for both groups indicated that the Accuplacer scores and matriculation results contribute unique information about academic performance. Cluster analysis for both groups yielded three underlying patterns of performance in the data sets. An attempt was made to validate the cluster groups internally through a MANOVA and single-factor ANOVAs. It was found that Accuplacer subtests and matriculation results do discriminate to an extent among clusters of learners in both groups of degree programmes investigated. Clusters were described in terms of demographic information and it was determined that the factors of culture and home language and how they relate to cluster group membership need further investigation. The main suggestion flowing from these findings is that an attempt be made to confirm the results with a larger sample size and for different cultural and language groups.
- Full Text:
- Date Issued: 2002
The medicinal chemistry of the isomers of the cyclic dipeptide: cyclo(Trp-Pro)
- Authors: Jamie, Hajierah
- Date: 2002
- Subjects: Pharmaceutical chemistry , Cyclic compounds
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:11023 , http://hdl.handle.net/10948/281 , Pharmaceutical chemistry , Cyclic compounds
- Description: The isomers of cyclo(Trp-Pro) (cyclo(L-Trp-L-Pro), cyclo(L-Trp-D-Pro), cyclo(D-Trp-LPro) and cyclo(D-Trp-D-Pro)) have been successfully synthesized and screened for biological activity. High percentage yields were obtained by using the three phase synthesis system, which involves the synthesis of the intermediate protected linear dipeptides, followed by the removal of the protecting Boc groups. This step is followed by cyclization and crystallization of the isomers. The diketopiperazines rings of cyclo(L-Trp-L-Pro) and cyclo(D-Trp-D-Pro) contain cisamide bonds, while cyclo(L-Trp-D-Pro) and cyclo(D-Trp-L-Pro) contain trans-amide bonds. These bonds govern the conformation of the diketopiperazines ring. The isomers have shown different degrees of biological activity, possibly as a result of the orientation of the side chain of tryptophan and this difference in conformation, leading to varying interactions between isomer and a range of receptors. Under experimental conditions, 10-3 M cyclo(L-Trp-D-Pro) and cyclo(D-Trp-L-Pro) showed effective anticancer activity against the cervical cancer cell line, HeLa, resulting in a <50% reduction in cell viability. Cytotoxicity screening with cyclo(D-Trp-L-Pro) indicated that it was hepatocyte-specific in its toxicity, whilst the other isomers were cytotoxic against the other cell types tested. At 1mg/ml, cyclo(L-Trp-L-Pro) proved to be an effective antimicrobial agent against Gram positive bacteria, while cyclo(L-Trp-DPro) effectively inhibited the growth of the Gram negative bacteria, Esherichia coli. Cyclo(D-Trp-L-Pro) proved to be effective against Streptococcus, while cyclo(D-Trp-DPro) effectively reduced viability of the yeast, Candida albicans. Cyclo(D-Trp-L-Pro) was the only isomer to show Ca2+-channel antagonism, whilst the other isomers resulted in opening of the Ca2+-channel. No effects were observed on K+-channel activity for all the isomers tested. The isomers also proved to be valuable antiarrhythmic agents by effectively reducing the time spent in ventricular tachycardia and arrhythmia, as well as decreasing the time for the heart rate to return to a normal sinus rhythm. Furthermore, cyclo(L-Trp-D-Pro) showed positive chronotropic activity, while cyclo(D-Trp-L-Pro) ii showed negative chronotropic activity. In addition, cyclo(L-Trp-D-Pro) and cyclo(D-Trp- L-Pro) also increased the coronary flow rate. 0.125 1 mM Cyclo(L-Trp-D-Pro) decreased aggregation in washed platelets induced by thrombin. All isomers increased adhesion to an artificial surface when the platelets were stimulated by ADP, yet caused reduced adhesion when the platelets were stimulated by thrombin. These results prove the potential of these compounds as novel agents in a range of biological fields, indicating that a combination of L- and D- amino acids may prove more effective than an agent consisting solely of L-amino acids.
- Full Text:
- Date Issued: 2002
- Authors: Jamie, Hajierah
- Date: 2002
- Subjects: Pharmaceutical chemistry , Cyclic compounds
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:11023 , http://hdl.handle.net/10948/281 , Pharmaceutical chemistry , Cyclic compounds
- Description: The isomers of cyclo(Trp-Pro) (cyclo(L-Trp-L-Pro), cyclo(L-Trp-D-Pro), cyclo(D-Trp-LPro) and cyclo(D-Trp-D-Pro)) have been successfully synthesized and screened for biological activity. High percentage yields were obtained by using the three phase synthesis system, which involves the synthesis of the intermediate protected linear dipeptides, followed by the removal of the protecting Boc groups. This step is followed by cyclization and crystallization of the isomers. The diketopiperazines rings of cyclo(L-Trp-L-Pro) and cyclo(D-Trp-D-Pro) contain cisamide bonds, while cyclo(L-Trp-D-Pro) and cyclo(D-Trp-L-Pro) contain trans-amide bonds. These bonds govern the conformation of the diketopiperazines ring. The isomers have shown different degrees of biological activity, possibly as a result of the orientation of the side chain of tryptophan and this difference in conformation, leading to varying interactions between isomer and a range of receptors. Under experimental conditions, 10-3 M cyclo(L-Trp-D-Pro) and cyclo(D-Trp-L-Pro) showed effective anticancer activity against the cervical cancer cell line, HeLa, resulting in a <50% reduction in cell viability. Cytotoxicity screening with cyclo(D-Trp-L-Pro) indicated that it was hepatocyte-specific in its toxicity, whilst the other isomers were cytotoxic against the other cell types tested. At 1mg/ml, cyclo(L-Trp-L-Pro) proved to be an effective antimicrobial agent against Gram positive bacteria, while cyclo(L-Trp-DPro) effectively inhibited the growth of the Gram negative bacteria, Esherichia coli. Cyclo(D-Trp-L-Pro) proved to be effective against Streptococcus, while cyclo(D-Trp-DPro) effectively reduced viability of the yeast, Candida albicans. Cyclo(D-Trp-L-Pro) was the only isomer to show Ca2+-channel antagonism, whilst the other isomers resulted in opening of the Ca2+-channel. No effects were observed on K+-channel activity for all the isomers tested. The isomers also proved to be valuable antiarrhythmic agents by effectively reducing the time spent in ventricular tachycardia and arrhythmia, as well as decreasing the time for the heart rate to return to a normal sinus rhythm. Furthermore, cyclo(L-Trp-D-Pro) showed positive chronotropic activity, while cyclo(D-Trp-L-Pro) ii showed negative chronotropic activity. In addition, cyclo(L-Trp-D-Pro) and cyclo(D-Trp- L-Pro) also increased the coronary flow rate. 0.125 1 mM Cyclo(L-Trp-D-Pro) decreased aggregation in washed platelets induced by thrombin. All isomers increased adhesion to an artificial surface when the platelets were stimulated by ADP, yet caused reduced adhesion when the platelets were stimulated by thrombin. These results prove the potential of these compounds as novel agents in a range of biological fields, indicating that a combination of L- and D- amino acids may prove more effective than an agent consisting solely of L-amino acids.
- Full Text:
- Date Issued: 2002
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