Visit the COVID-19 Corona Virus South African Resource Portal on https://sacoronavirus.co.za/
Multi-drug resistant tuberculosis related adverse drug reactions: implementation of a documentation tool
- Authors: Cheng, Amber
- Date: 2019
- Subjects: Multi-drug resistant tuberculosis
- Language: English
- Type: Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10948/44662 , vital:38151
- Description: Multi-drug resistant tuberculosis (MDR-TB) is an ever-growing problem in South Africa (SA). According to the literature, minimal documentation is done on adverse drug reactions (ADRs), specifically in the MDR-TB population. Co-administration of medications is typical for the treatment of drug resistant forms of TB, which leads to high incidences of ADRs during the treatment period, especially in patients with comorbid disease states. This before-and-after study investigated the impact of an intervention (education training presentation and implementation of a purpose-designed documentation tool) on the current documentation pattern in a public sector hospital in the Nelson Mandela Metropole. In order to measure the sustainability of the intervention, the study compared data from the pre-intervention phase to data collected from the post-intervention immediate phase and post-intervention delayed phase. Study results indicated that the intervention appeared to have had a positive effect on the frequency and variety of ADR documentation (2.1 and 1.3 fold increase, respectively) related to MDR-TB by the hospital staff of a public sector hospital, however, the positive change was not sustainable for longer than a three month period post intervention. It is recommended that factors such as: proper adoption; management; and additional resources are required to implement positive changes to documentation practices. Further studies need to be conducted in South Africa regarding the treatment of drug resistant tuberculosis, in order to establish safer treatment guidelines and more promising ADR reporting practices, which will ultimately improve patient care.
- Full Text:
- Date Issued: 2019
- Authors: Cheng, Amber
- Date: 2019
- Subjects: Multi-drug resistant tuberculosis
- Language: English
- Type: Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10948/44662 , vital:38151
- Description: Multi-drug resistant tuberculosis (MDR-TB) is an ever-growing problem in South Africa (SA). According to the literature, minimal documentation is done on adverse drug reactions (ADRs), specifically in the MDR-TB population. Co-administration of medications is typical for the treatment of drug resistant forms of TB, which leads to high incidences of ADRs during the treatment period, especially in patients with comorbid disease states. This before-and-after study investigated the impact of an intervention (education training presentation and implementation of a purpose-designed documentation tool) on the current documentation pattern in a public sector hospital in the Nelson Mandela Metropole. In order to measure the sustainability of the intervention, the study compared data from the pre-intervention phase to data collected from the post-intervention immediate phase and post-intervention delayed phase. Study results indicated that the intervention appeared to have had a positive effect on the frequency and variety of ADR documentation (2.1 and 1.3 fold increase, respectively) related to MDR-TB by the hospital staff of a public sector hospital, however, the positive change was not sustainable for longer than a three month period post intervention. It is recommended that factors such as: proper adoption; management; and additional resources are required to implement positive changes to documentation practices. Further studies need to be conducted in South Africa regarding the treatment of drug resistant tuberculosis, in order to establish safer treatment guidelines and more promising ADR reporting practices, which will ultimately improve patient care.
- Full Text:
- Date Issued: 2019
Uptake of liposomes into bacterial cells
- Authors: Oidu, Benjamin
- Date: 2013
- Subjects: Liposomes , Drug carriers (Pharmacy)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10165 , http://hdl.handle.net/10948/d1021010
- Description: Liposomes are small phospholipid vesicles that have been widely investigated as drug carriers for the delivery of therapeutic agents. A variety of liposome formulations are presently under clinical trial exploration, while others have already been approved for clinical use. The aim of this study was to optimize liposome uptake into bacterial cells. Both gram-positive and gram-negative bacteria were used in the study as well as Candida albicans.Response surface methodology (RSM) using a central composite design (CCD) model was used to optimize liposomal formulations of carboxyfluorescien (CF) for each of the three microbes, and also the three microbes in combination namely; Staphylococcus aureus (Sa), Escherichia coli (Ec) and Candida albicans (Ca). Percentage of CF encapsulated and CF increase in Uptake were investigated with respect to two independent variables that were, cholesterol (CHOL) and stearylamine (SA) content. Design Expert 8 was used for the purpose of finding the combination of independent variables that would yield an optimal formulation for each microbe and the three microbes in combination. The model selected by the software managed to reasonably correlate the predicted models to the experimental data. Encapsulation of carboxyfluorescien (CF) into a liposome formulation enhanced its uptake by Staphylococcus aureus and Escherichia coli as well as Candida albicans. This was evident in the increase in CF uptake when the uptake rate of free CF was compared with that of liposomal CF.
- Full Text:
- Date Issued: 2013
- Authors: Oidu, Benjamin
- Date: 2013
- Subjects: Liposomes , Drug carriers (Pharmacy)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10165 , http://hdl.handle.net/10948/d1021010
- Description: Liposomes are small phospholipid vesicles that have been widely investigated as drug carriers for the delivery of therapeutic agents. A variety of liposome formulations are presently under clinical trial exploration, while others have already been approved for clinical use. The aim of this study was to optimize liposome uptake into bacterial cells. Both gram-positive and gram-negative bacteria were used in the study as well as Candida albicans.Response surface methodology (RSM) using a central composite design (CCD) model was used to optimize liposomal formulations of carboxyfluorescien (CF) for each of the three microbes, and also the three microbes in combination namely; Staphylococcus aureus (Sa), Escherichia coli (Ec) and Candida albicans (Ca). Percentage of CF encapsulated and CF increase in Uptake were investigated with respect to two independent variables that were, cholesterol (CHOL) and stearylamine (SA) content. Design Expert 8 was used for the purpose of finding the combination of independent variables that would yield an optimal formulation for each microbe and the three microbes in combination. The model selected by the software managed to reasonably correlate the predicted models to the experimental data. Encapsulation of carboxyfluorescien (CF) into a liposome formulation enhanced its uptake by Staphylococcus aureus and Escherichia coli as well as Candida albicans. This was evident in the increase in CF uptake when the uptake rate of free CF was compared with that of liposomal CF.
- Full Text:
- Date Issued: 2013
Influence of distance from the target on total response time, repeated punch force and anaerobic fatigue of amatuer boxers
- Authors: Trella, Christopher Andrew
- Date: 2012
- Subjects: Boxers (Sports) , Physical education and training
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:10111 , http://hdl.handle.net/10948/d1020942
- Description: The aim of this study was to determine the influence of distance from the target during dominant and non-dominant jab punches, on total response time, repeated jab punch force and anaerobic fatigue of amateur boxers. Data was gathered of the following variables: Biographical data, anthropometric data, total response time, change in total response time, number of punches, peak punch force and peak punch force fatigue resistance index. An exploratory and descriptive research design was used. Twelve male amateur boxers participated in this study. The participants were all either provincially or nationally ranked, between the ages 16 and 22 and in the competitive phase of their training. The data was compared to find statistical significance and it was found from the Wilcoxon ranked sign test that distance does not affect total response time, change in total response time, number of punches and peak punch force fatigue resistance index. However, it was found that distance affects peak punch force. Additionally,it was found using a Spearman rank correlation test that older boxers proved to have statistically significant faster total response times, the boxers that had slower total reponse times proved to have statistically significant less powerful peak punch force, the boxers that had slower total response times proved to have statistically significant larger fatigue resistance index, boxers with larger change in total response time proved to have statistically significant more powerful peak punch force and the boxers with larger peak punch force proved to have statistically significant smaller fatigue resistance index. The data presented provides an introduction of the exploration of how distance from a target relates to a boxer’s performance.
- Full Text:
- Date Issued: 2012
- Authors: Trella, Christopher Andrew
- Date: 2012
- Subjects: Boxers (Sports) , Physical education and training
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:10111 , http://hdl.handle.net/10948/d1020942
- Description: The aim of this study was to determine the influence of distance from the target during dominant and non-dominant jab punches, on total response time, repeated jab punch force and anaerobic fatigue of amateur boxers. Data was gathered of the following variables: Biographical data, anthropometric data, total response time, change in total response time, number of punches, peak punch force and peak punch force fatigue resistance index. An exploratory and descriptive research design was used. Twelve male amateur boxers participated in this study. The participants were all either provincially or nationally ranked, between the ages 16 and 22 and in the competitive phase of their training. The data was compared to find statistical significance and it was found from the Wilcoxon ranked sign test that distance does not affect total response time, change in total response time, number of punches and peak punch force fatigue resistance index. However, it was found that distance affects peak punch force. Additionally,it was found using a Spearman rank correlation test that older boxers proved to have statistically significant faster total response times, the boxers that had slower total reponse times proved to have statistically significant less powerful peak punch force, the boxers that had slower total response times proved to have statistically significant larger fatigue resistance index, boxers with larger change in total response time proved to have statistically significant more powerful peak punch force and the boxers with larger peak punch force proved to have statistically significant smaller fatigue resistance index. The data presented provides an introduction of the exploration of how distance from a target relates to a boxer’s performance.
- Full Text:
- Date Issued: 2012
Levels of selected heavy metals in garden soil in Walmer Township and Wells Estate, Port Elizabeth
- Ogunfowora, Ebunoluwa Juliana
- Authors: Ogunfowora, Ebunoluwa Juliana
- Date: 2019
- Subjects: Environmental health -- South Africa -- Port Elizabeth , Environmental chemistry , Pollution -- Physiological effect
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: http://hdl.handle.net/10948/42990 , vital:36722
- Description: Heavy metals are naturally occurring elements that have high densities. Heavy metals have been found to have applications in various sectors such as the industrial, domestic, agricultural and medical sectors, thus resulting in environmental pollution which may pose a hazard to human health. Heavy metals such as arsenic, cadmium, manganese, lead and mercury rank among the priority metals that are of public health significance, and they are commonly found in garden soils. In this study, residential garden soils were sampled in dwelling sites in Wells Estate and Walmer Township, and analysed for mercury, cadmium, arsenic, manganese and lead. A cross sectional design was employed in this study. The research was carried out in two phases; the first phase involved soil sample collection, preparation and laboratory work for the determination of heavy metal concentrations. The second phase focused on the social aspect of the study population which included the use of a pre-approved questionnaire and face-to-face interviews for the collection of human health related information at each dwelling site where soil samples were collected. The research protocol was approved by the Health Sciences Faculty Postgraduate Studies Committees (FPGSC) of Nelson Mandela University. Garden soil from residential yards of Wells Estate (near an industrial site, ̴ 2 km) and Walmer Township (further away from the industrial site (̴ 22 km), but relatively close to Port Elizabeth airport, ̴ 2 km) were sampled over a total of six sampling sessions resulting in 100 soil samples. Fifty soil samples were collected in Wells Estate and fifty soil samples in Walmer Township during the month of May 2017. Surface soil samples were collected from the top 2 cm of the soil using a sterile stainless-steel spoon. In addition to the collection of soil samples, a visual inspection of the house was undertaken to collect information about the house characteristics, geographic location (GPS coordinates) and characteristics of the surrounding area. Soil samples were prepared for analysis by grinding and drying followed by heavy metal determination using an X-ray fluorescence (XRF) analyser (Bruker s1 TITAN Analyser, USA). A face-to-face questionnaire was administered to a suitable respondent at each dwelling site to obtain information related to health symptoms such as coughing, fever, chest pains, earache, sore throat, headaches, rapid breathing, sneezing, running/blocked nose, teary watery eyes, cancer, hypertension, heart diseases and mental illness. The mean concentrations of heavy metals were in the order manganese>lead>arsenic for both study sites. In Walmer Township soil samples, the mean concentrations of heavy metals determined were 154.8 mg/kg, 84.4 mg/kg and 5.4 mg/kg for manganese, lead, and arsenic, respectively. Mean concentrations of heavy metals as determined in Wells Estate were 322.2 mg/kg, 11.5 mg/kg, and 3.4 mg/kg for manganese, lead and arsenic, respectively. Manganese concentration across the study sites are below the guideline levels for USA (630 mg/kg) and South African (1500 mg/kg). About 2.0% of the sample exceeded the South African lead guideline level of 230 mg/kg, while 4.1% exceeded European lead level of 400 mg/kg in Walmer Township. Lead levels in Wells Estate were all below the South African, European and United States guideline levels. By contrast, 2.0% of the sample exceeded the South African arsenic guideline level of 48 mg/kg, 2.0% exceeded European arsenic guideline level of 50 mg/kg and 2.0% exceeded USA arsenic guideline level of 11 mg/kg in Walmer Township, while 2.0% exceeded USA arsenic guideline level of 11 mg/kg in Wells Estate. Mann Whitney U test showed statistically significant differences between lead levels (U=1527, p < 0.001) and manganese levels (U=2632, p < 0.001) across study sites. Soil manganese level showed significant association with age of house (crude OR: 0.34, 95% CI: 0.14-0.83, p =0.016). Using data obtained from the questionnaire, a multivariate logistic regression analysis was performed to examine the relationship between soil heavy metals and the various health outcomes. In Walmer Township, manganese showed association with dry cough (OR: 11.35, 95% CI: 1.08-119.20) and sneezing (OR: 11.30, 95% CI: 1.09-116.67). Manganese was also associated with wet cough (OR: 0.19 95% CI: 0.05-0.70), dry cough (OR: 0.22, 95% CI: 0.06-0.83) and watery eye (OR: 4.55, 95% CI: 1.01-20.58) in Wells Estate. Dry cough (OR: 0.31, 95% CI: 0.16-0.64), sneezing (OR: 2.18, 95% CI: 1.06-4.48) and watery eye adjusted (OR: 3.71, 95% CI: 1.63-8.48) were also associated with manganese in the total sample. Confounding factors such as overcrowding (adjusted OR = 2.23; 95% CI: 1.11-4.48) and air pollution (adjusted OR = 2.76; 95% CI:1.39-5.50), predicted wet cough and sneezing, respectively, across the total sample. Heavy metal concentration in most of the study dwellings of Walmer Township and Wells Estate were below the safe limit recommended by United States, European and South Africa soil reference levels. Nevertheless, we found a strong association between manganese and respiratory symptoms such as dry cough and sneezing in Walmer Township, as well as a strong association between manganese and watery eyes in Wells Estate. There was no evidence of associations between heavy metal exposure and gastrointestinal symptoms, chronic diseases and mental illness.
- Full Text:
- Date Issued: 2019
- Authors: Ogunfowora, Ebunoluwa Juliana
- Date: 2019
- Subjects: Environmental health -- South Africa -- Port Elizabeth , Environmental chemistry , Pollution -- Physiological effect
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: http://hdl.handle.net/10948/42990 , vital:36722
- Description: Heavy metals are naturally occurring elements that have high densities. Heavy metals have been found to have applications in various sectors such as the industrial, domestic, agricultural and medical sectors, thus resulting in environmental pollution which may pose a hazard to human health. Heavy metals such as arsenic, cadmium, manganese, lead and mercury rank among the priority metals that are of public health significance, and they are commonly found in garden soils. In this study, residential garden soils were sampled in dwelling sites in Wells Estate and Walmer Township, and analysed for mercury, cadmium, arsenic, manganese and lead. A cross sectional design was employed in this study. The research was carried out in two phases; the first phase involved soil sample collection, preparation and laboratory work for the determination of heavy metal concentrations. The second phase focused on the social aspect of the study population which included the use of a pre-approved questionnaire and face-to-face interviews for the collection of human health related information at each dwelling site where soil samples were collected. The research protocol was approved by the Health Sciences Faculty Postgraduate Studies Committees (FPGSC) of Nelson Mandela University. Garden soil from residential yards of Wells Estate (near an industrial site, ̴ 2 km) and Walmer Township (further away from the industrial site (̴ 22 km), but relatively close to Port Elizabeth airport, ̴ 2 km) were sampled over a total of six sampling sessions resulting in 100 soil samples. Fifty soil samples were collected in Wells Estate and fifty soil samples in Walmer Township during the month of May 2017. Surface soil samples were collected from the top 2 cm of the soil using a sterile stainless-steel spoon. In addition to the collection of soil samples, a visual inspection of the house was undertaken to collect information about the house characteristics, geographic location (GPS coordinates) and characteristics of the surrounding area. Soil samples were prepared for analysis by grinding and drying followed by heavy metal determination using an X-ray fluorescence (XRF) analyser (Bruker s1 TITAN Analyser, USA). A face-to-face questionnaire was administered to a suitable respondent at each dwelling site to obtain information related to health symptoms such as coughing, fever, chest pains, earache, sore throat, headaches, rapid breathing, sneezing, running/blocked nose, teary watery eyes, cancer, hypertension, heart diseases and mental illness. The mean concentrations of heavy metals were in the order manganese>lead>arsenic for both study sites. In Walmer Township soil samples, the mean concentrations of heavy metals determined were 154.8 mg/kg, 84.4 mg/kg and 5.4 mg/kg for manganese, lead, and arsenic, respectively. Mean concentrations of heavy metals as determined in Wells Estate were 322.2 mg/kg, 11.5 mg/kg, and 3.4 mg/kg for manganese, lead and arsenic, respectively. Manganese concentration across the study sites are below the guideline levels for USA (630 mg/kg) and South African (1500 mg/kg). About 2.0% of the sample exceeded the South African lead guideline level of 230 mg/kg, while 4.1% exceeded European lead level of 400 mg/kg in Walmer Township. Lead levels in Wells Estate were all below the South African, European and United States guideline levels. By contrast, 2.0% of the sample exceeded the South African arsenic guideline level of 48 mg/kg, 2.0% exceeded European arsenic guideline level of 50 mg/kg and 2.0% exceeded USA arsenic guideline level of 11 mg/kg in Walmer Township, while 2.0% exceeded USA arsenic guideline level of 11 mg/kg in Wells Estate. Mann Whitney U test showed statistically significant differences between lead levels (U=1527, p < 0.001) and manganese levels (U=2632, p < 0.001) across study sites. Soil manganese level showed significant association with age of house (crude OR: 0.34, 95% CI: 0.14-0.83, p =0.016). Using data obtained from the questionnaire, a multivariate logistic regression analysis was performed to examine the relationship between soil heavy metals and the various health outcomes. In Walmer Township, manganese showed association with dry cough (OR: 11.35, 95% CI: 1.08-119.20) and sneezing (OR: 11.30, 95% CI: 1.09-116.67). Manganese was also associated with wet cough (OR: 0.19 95% CI: 0.05-0.70), dry cough (OR: 0.22, 95% CI: 0.06-0.83) and watery eye (OR: 4.55, 95% CI: 1.01-20.58) in Wells Estate. Dry cough (OR: 0.31, 95% CI: 0.16-0.64), sneezing (OR: 2.18, 95% CI: 1.06-4.48) and watery eye adjusted (OR: 3.71, 95% CI: 1.63-8.48) were also associated with manganese in the total sample. Confounding factors such as overcrowding (adjusted OR = 2.23; 95% CI: 1.11-4.48) and air pollution (adjusted OR = 2.76; 95% CI:1.39-5.50), predicted wet cough and sneezing, respectively, across the total sample. Heavy metal concentration in most of the study dwellings of Walmer Township and Wells Estate were below the safe limit recommended by United States, European and South Africa soil reference levels. Nevertheless, we found a strong association between manganese and respiratory symptoms such as dry cough and sneezing in Walmer Township, as well as a strong association between manganese and watery eyes in Wells Estate. There was no evidence of associations between heavy metal exposure and gastrointestinal symptoms, chronic diseases and mental illness.
- Full Text:
- Date Issued: 2019
An investigation into the introduction of process analytical technology, using near infrared analysis, to selected pharmaceutical processes
- Authors: Naicker, Krishnaveni
- Date: 2007
- Subjects: Near infrared spectroscopy , Pharmaceutical chemistry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10153 , http://hdl.handle.net/10948/577 , http://hdl.handle.net/10948/d1011710 , Near infrared spectroscopy , Pharmaceutical chemistry
- Description: Introduction: Process analytical technologies are systems for the analysis and control of manufacturing processes to assure acceptable end-product quality. This is achieved by timely measurements of critical parameters and performance attributes of raw material and in-process material and processes. The introduction of process analytical technology using near infrared analysis was investigated in three areas, namely incoming raw material analysis, blend uniformity analysis and moisture determination in the fluid bed dryer. Methodology: Incoming raw material identification - The FOSS XDS rapid content analyzer was used for the development of a NIR method for the identification and material qualification of starch maize and lactose monohydrate. Blend uniformity analysis – The SP15 Laboratory Blender fitted with near infrared probe was utilized for the study. Two types of blend experiments were designed to monitor the distribution of magnesium stearate (lubricant) in the blend, namely, a powder blend utilizing lactose monohydrate and a granule blend utilizing Ridaq® granule. Software methods were developed to monitor the standard deviation of the absorbance at the wavelengths that were specific for lactose monohydrate, Ridaq® granule and magnesium stearate. To confirm the prediction of end-point using near infrared, results were verified using an atomic absorption method for magnesium stearate. The blends were sampled at the selected time intervals corresponding to three states of the blend, namely, before end-point, at end-point and after end-point using a sampling plan. An additional six blends were conducted for the granule blend and sampled when the standard deviation had reached a value below 3 x 10-6 at the magnesium stearate wavelength at four consecutive data points (standard deviation value extrapolated from blends carried out to predetermined time intervals). Moisture determination in the fluid bed dryer – Moisture values for two products (Product A and Product B) were retrospectively collected from past production batches. A process capability study was conducted on the moisture values to determine if the current process was in a state of control. Results and Discussion: Incoming raw material identification – The algorithms used for the spectral library were able to distinguish between the raw materials selected. The spectral library positively identified the starch maize and lactose monohydrate samples that were not present in the library. The negative challenge with pregelatinised starch and tablettose demonstrated that the spectral library was able to differentiate between closely related compounds. Blend uniformity analysis – Blends sampled at the predetermined time intervals demonstrated a homogeneous state when the standard deviation of the absorbance was low and a non-homogeneous state when the standard deviation of the absorbance was high, thus near infrared prediction on the state of the blend was confirmed by the standard analytical methods. The series of Ridaq® granule and magnesium stearate blends sampled when the standard deviation was below 3 x 10-6 were homogeneous with the exception of one blend that was marginally out of specification. Blend durations were significantly lower than the standard blend durations used in the facility and ranged from 112 to 198 seconds. Moisture determination in the fluid bed dryer – From the process capability study of the two products it was noted that Product A is stable but can still be optimized while Product B is at a desirable state. The statistical evaluation of the moisture values for Product A and Product B demonstrated that the use of the product temperature to monitor the moisture gave consistent results. The current process is stable and capable of producing repeatable results although near infrared provides a means for continuously monitoring the product moisture and allows one to take action to prevent over-drying or under-drying. Conclusion: From the investigations conducted, it can be seen that there is definitely a niche for process analytical technology at this pharmaceutical company. The implementation is a gradual process of change, which may take time, probably several years (Heinze & Hansen 2005).
- Full Text:
- Date Issued: 2007
- Authors: Naicker, Krishnaveni
- Date: 2007
- Subjects: Near infrared spectroscopy , Pharmaceutical chemistry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10153 , http://hdl.handle.net/10948/577 , http://hdl.handle.net/10948/d1011710 , Near infrared spectroscopy , Pharmaceutical chemistry
- Description: Introduction: Process analytical technologies are systems for the analysis and control of manufacturing processes to assure acceptable end-product quality. This is achieved by timely measurements of critical parameters and performance attributes of raw material and in-process material and processes. The introduction of process analytical technology using near infrared analysis was investigated in three areas, namely incoming raw material analysis, blend uniformity analysis and moisture determination in the fluid bed dryer. Methodology: Incoming raw material identification - The FOSS XDS rapid content analyzer was used for the development of a NIR method for the identification and material qualification of starch maize and lactose monohydrate. Blend uniformity analysis – The SP15 Laboratory Blender fitted with near infrared probe was utilized for the study. Two types of blend experiments were designed to monitor the distribution of magnesium stearate (lubricant) in the blend, namely, a powder blend utilizing lactose monohydrate and a granule blend utilizing Ridaq® granule. Software methods were developed to monitor the standard deviation of the absorbance at the wavelengths that were specific for lactose monohydrate, Ridaq® granule and magnesium stearate. To confirm the prediction of end-point using near infrared, results were verified using an atomic absorption method for magnesium stearate. The blends were sampled at the selected time intervals corresponding to three states of the blend, namely, before end-point, at end-point and after end-point using a sampling plan. An additional six blends were conducted for the granule blend and sampled when the standard deviation had reached a value below 3 x 10-6 at the magnesium stearate wavelength at four consecutive data points (standard deviation value extrapolated from blends carried out to predetermined time intervals). Moisture determination in the fluid bed dryer – Moisture values for two products (Product A and Product B) were retrospectively collected from past production batches. A process capability study was conducted on the moisture values to determine if the current process was in a state of control. Results and Discussion: Incoming raw material identification – The algorithms used for the spectral library were able to distinguish between the raw materials selected. The spectral library positively identified the starch maize and lactose monohydrate samples that were not present in the library. The negative challenge with pregelatinised starch and tablettose demonstrated that the spectral library was able to differentiate between closely related compounds. Blend uniformity analysis – Blends sampled at the predetermined time intervals demonstrated a homogeneous state when the standard deviation of the absorbance was low and a non-homogeneous state when the standard deviation of the absorbance was high, thus near infrared prediction on the state of the blend was confirmed by the standard analytical methods. The series of Ridaq® granule and magnesium stearate blends sampled when the standard deviation was below 3 x 10-6 were homogeneous with the exception of one blend that was marginally out of specification. Blend durations were significantly lower than the standard blend durations used in the facility and ranged from 112 to 198 seconds. Moisture determination in the fluid bed dryer – From the process capability study of the two products it was noted that Product A is stable but can still be optimized while Product B is at a desirable state. The statistical evaluation of the moisture values for Product A and Product B demonstrated that the use of the product temperature to monitor the moisture gave consistent results. The current process is stable and capable of producing repeatable results although near infrared provides a means for continuously monitoring the product moisture and allows one to take action to prevent over-drying or under-drying. Conclusion: From the investigations conducted, it can be seen that there is definitely a niche for process analytical technology at this pharmaceutical company. The implementation is a gradual process of change, which may take time, probably several years (Heinze & Hansen 2005).
- Full Text:
- Date Issued: 2007
Ernesto "Che" Guevara : a psychobiographical study
- Authors: Kolesky, Candice
- Date: 2010
- Subjects: Guevara, Che, 1928-1967 , Psychology -- Biographical methods
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9864 , http://hdl.handle.net/10948/1512 , Guevara, Che, 1928-1967 , Psychology -- Biographical methods
- Description: Psychobiography is a qualitative approach to exploring and understanding the life story of an individual through the lens of psychological theory. The application of theory is typically done on the finished lives of well-known or enigmatic people. This study explores and describes the psychological development across the lifespan of Ernesto “Che” Guevara, by applying the Individual Psychology of Alfred Adler. Che Guevara was an Argentine Marxist revolutionary, physician, author, guerrilla leader, and major figure of the Cuban Revolution. Since his death, his image has become a symbol for revolution within popular culture. Extensive data has been examined in this work to ensure an accurate description of Guevara’s life. Alexander’s model of identifying salient themes was used to analyze the data within a conceptual framework derived from the theory. Guevara was fiercely loyal to his cause, at the expense of the lives of many Cuban citizens as well as his own family, whom he spent little time with. He justified this with his firmly held belief that the end justified the means and that he was always fighting for the greater good. He quite literally dedicated his life to his cause, which is the reason that he has become a modern day symbol for revolution. It is however unfortunate that this came at such a great personal expense.
- Full Text:
- Date Issued: 2010
- Authors: Kolesky, Candice
- Date: 2010
- Subjects: Guevara, Che, 1928-1967 , Psychology -- Biographical methods
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9864 , http://hdl.handle.net/10948/1512 , Guevara, Che, 1928-1967 , Psychology -- Biographical methods
- Description: Psychobiography is a qualitative approach to exploring and understanding the life story of an individual through the lens of psychological theory. The application of theory is typically done on the finished lives of well-known or enigmatic people. This study explores and describes the psychological development across the lifespan of Ernesto “Che” Guevara, by applying the Individual Psychology of Alfred Adler. Che Guevara was an Argentine Marxist revolutionary, physician, author, guerrilla leader, and major figure of the Cuban Revolution. Since his death, his image has become a symbol for revolution within popular culture. Extensive data has been examined in this work to ensure an accurate description of Guevara’s life. Alexander’s model of identifying salient themes was used to analyze the data within a conceptual framework derived from the theory. Guevara was fiercely loyal to his cause, at the expense of the lives of many Cuban citizens as well as his own family, whom he spent little time with. He justified this with his firmly held belief that the end justified the means and that he was always fighting for the greater good. He quite literally dedicated his life to his cause, which is the reason that he has become a modern day symbol for revolution. It is however unfortunate that this came at such a great personal expense.
- Full Text:
- Date Issued: 2010
Psychologists' perceived influences of early strategies on the psychosocial response to those affected by disasters
- Authors: Blackburn, Nerina June
- Date: 2010
- Subjects: Disasters -- Psychological aspects , Post-traumatic stress disorder , Disaster victims -- Mental health , Disasters
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9872 , http://hdl.handle.net/10948/1416 , Disasters -- Psychological aspects , Post-traumatic stress disorder , Disaster victims -- Mental health , Disasters
- Description: Currently some confusion exists as to how health professionals should best respond to the psychological needs of those affected by disasters. Some have argued that early psychological intervention is essential and others have argued that early formal psychological interventions have no useful role in post trauma response. This study highlights the importance of considering both counselling and non-counselling factors as potentially influencing the psychosocial response of disaster victims. Although posttraumatic stress disorder (PTSD) is not the only mental disorder that can develop as a result of exposure to disasters, it is probably the most frequent and debilitating psychological disorder associated with traumatic stress. In this exploratorydescriptive study the researcher aimed to explore and describe psychologists’ perceived influences of early strategies on the psychosocial response to those affected by disaster. The researcher used non-probability snowball sampling to access participants. The sample consisted of 5 participants. Semi structured interviews were conducted. Content analysis was used to analyse the data obtained from interviews. Results that emerged from the data suggest that there are many factors that influence the psychosocial response to those affected by disasters. These factors include the screening process, needs of survivors, the method of choice for treatment, the timing of intervention, pharmacology, the South African context, training and planning. The study makes a contribution to the growing knowledge of early strategies in response to those affected by disasters.
- Full Text:
- Date Issued: 2010
- Authors: Blackburn, Nerina June
- Date: 2010
- Subjects: Disasters -- Psychological aspects , Post-traumatic stress disorder , Disaster victims -- Mental health , Disasters
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9872 , http://hdl.handle.net/10948/1416 , Disasters -- Psychological aspects , Post-traumatic stress disorder , Disaster victims -- Mental health , Disasters
- Description: Currently some confusion exists as to how health professionals should best respond to the psychological needs of those affected by disasters. Some have argued that early psychological intervention is essential and others have argued that early formal psychological interventions have no useful role in post trauma response. This study highlights the importance of considering both counselling and non-counselling factors as potentially influencing the psychosocial response of disaster victims. Although posttraumatic stress disorder (PTSD) is not the only mental disorder that can develop as a result of exposure to disasters, it is probably the most frequent and debilitating psychological disorder associated with traumatic stress. In this exploratorydescriptive study the researcher aimed to explore and describe psychologists’ perceived influences of early strategies on the psychosocial response to those affected by disaster. The researcher used non-probability snowball sampling to access participants. The sample consisted of 5 participants. Semi structured interviews were conducted. Content analysis was used to analyse the data obtained from interviews. Results that emerged from the data suggest that there are many factors that influence the psychosocial response to those affected by disasters. These factors include the screening process, needs of survivors, the method of choice for treatment, the timing of intervention, pharmacology, the South African context, training and planning. The study makes a contribution to the growing knowledge of early strategies in response to those affected by disasters.
- Full Text:
- Date Issued: 2010
High-intensity Interval Training utilising a standardised versus customised training programme among endurance trained male cyclists
- Authors: Salzwedel, Jarred Wayne
- Date: 2020
- Subjects: Cycling South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/46423 , vital:39596
- Description: The primary aim of this study was to compare the effect of a standardised versus customised high-intensity interval training programmeon performance indicators of endurance trained male cyclists utilising a standardised method of prescribing intervals in comparison to a customised method of prescribing intervals based on training feedback. The study was exploratory and quasi-experimental in nature and utilized a quantitative approach. A quasi-experimental, pretest-postestcontrol group study design was used. A total number of 22 participants that met the inclusion criteria were included in the study by means of purposive sampling. The participants were subdivided into an experimental group (n=11) and a control group (n=11)by means of random stratification in order to ensure performance equality between the two groups. The experimental group completed a High-Intensity Interval Training (HIIT) block of 28 days (four weeks) with three weeks of interval-based sessions and one recovery week ending off the block. The programmeutilised the same “anaerobic” type intervals (10 x 30 seconds at 170% PPO with 4 minutes 30 seconds recovery) as the control group, performed twice per week for three consecutive weeks. The Lamberts and Lambert submaximal cycling test (LSCT) was used to determine whether a participant in the experimental group could start his HIIT session on a particular day.Participants were notallowed to start their HIIT session if twoor more of the set criteria weremet.If the participants did not qualify to participate in a HIIT session they were required to perform a low intensity training session in the same venue. Differences between the pre-and post-test showed statistically non-significant improvements (p>0.05) from pre-to post-test for both the experimental and control groups in respect of the physiological variables measured (gas exchange threshold, respiratory compensation point, maximal oxygen consumption). The experimental group did however show more positive, but statistically non-significantimprovements in peak power output. The findings of this study therefore showed that no significant within group nor between group improvements were achieved utilizing a standised versus customised HIIT training programme over the four-week study period. The findings do however suggest that the LSCT may have merit in prescribing HIIT sessions in trained athletesas suggested by the improvements of the experimental group’s peak power output.
- Full Text:
- Date Issued: 2020
- Authors: Salzwedel, Jarred Wayne
- Date: 2020
- Subjects: Cycling South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/46423 , vital:39596
- Description: The primary aim of this study was to compare the effect of a standardised versus customised high-intensity interval training programmeon performance indicators of endurance trained male cyclists utilising a standardised method of prescribing intervals in comparison to a customised method of prescribing intervals based on training feedback. The study was exploratory and quasi-experimental in nature and utilized a quantitative approach. A quasi-experimental, pretest-postestcontrol group study design was used. A total number of 22 participants that met the inclusion criteria were included in the study by means of purposive sampling. The participants were subdivided into an experimental group (n=11) and a control group (n=11)by means of random stratification in order to ensure performance equality between the two groups. The experimental group completed a High-Intensity Interval Training (HIIT) block of 28 days (four weeks) with three weeks of interval-based sessions and one recovery week ending off the block. The programmeutilised the same “anaerobic” type intervals (10 x 30 seconds at 170% PPO with 4 minutes 30 seconds recovery) as the control group, performed twice per week for three consecutive weeks. The Lamberts and Lambert submaximal cycling test (LSCT) was used to determine whether a participant in the experimental group could start his HIIT session on a particular day.Participants were notallowed to start their HIIT session if twoor more of the set criteria weremet.If the participants did not qualify to participate in a HIIT session they were required to perform a low intensity training session in the same venue. Differences between the pre-and post-test showed statistically non-significant improvements (p>0.05) from pre-to post-test for both the experimental and control groups in respect of the physiological variables measured (gas exchange threshold, respiratory compensation point, maximal oxygen consumption). The experimental group did however show more positive, but statistically non-significantimprovements in peak power output. The findings of this study therefore showed that no significant within group nor between group improvements were achieved utilizing a standised versus customised HIIT training programme over the four-week study period. The findings do however suggest that the LSCT may have merit in prescribing HIIT sessions in trained athletesas suggested by the improvements of the experimental group’s peak power output.
- Full Text:
- Date Issued: 2020
The endocannabinoid system in inflammatory bowel system
- Authors: Ababio, Frank James Kweku
- Date: 2014
- Subjects: Inflammatory bowel diseases , Gastrointestinal system , Gastrointestinal system -- Diseases
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10346 , http://hdl.handle.net/10948/d1020338
- Description: Crohn’s disease (CD) and ulcerative colitis (UC) constitute the two major forms of inflammatory bowel disease (IBD), which are disorders of chronic inflammation in the gastrointestinal tract that are associated with significant morbidity and socioeconomic burden. IBD patients with long-standing intestinal inflammation are more prone to developing colorectal cancer (CRC). Until now, none of the existing IBD treatments is able to heal the mucosal ulcerations satisfactorily. The endocannabinoid system (ECS), which comprises of endogenous cannabinoid ligands, their receptors, and metabolic enzymes, has been implicated in gut homeostasis, visceral sensation, inflammation and gastrointestinal motility. Available studies in rodent models of IBD suggest that enhancing the ECS tone may reduce inflammation and improve mucosal integrity. This evidence indicates that the components of the ECS seem well positioned to exert a protective role in IBD and also to offer a great opportunity for therapeutic exploitation. Despite the role of the ECS in the gut, the presence and function of the components of the ECS is not well characterised in human IBD. The primary aim of the study was to investigate the state of the major components of the ECS in human IBD and to establish whether IBD is associated with any changes of the components of the ECS. Cannabinoid CB1 and CB2 receptors, enzymes for endocannabinoid biosynthesis PLC, “LRAT”, NAPE-PLD and DAGL, and endocannabinoid metabolic enzymes FAAH and MAGL were analysed from colonic tissue samples of CD, UC and control patients by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) to determine the relative mRNA expression of the above genes. The RT-qPCR analysis showed that the mRNA expression of PLC, LRAT, and NAPE-PLD were unchanged in both CD and UC, whiles DAGL mRNA was decreased in UC but was unchanged in CD. The endocannabinoid degradation enzymes, FAAH mRNA expression was also unchanged in CD but decreased in UC, whereas the mRNA expression of MAGL was significantly decreased in both CD and UC. NAPE-PLD/FAAH and DAGL/MAGL ratios, an estimation of the balance of AEA and 2-AG levels, showed that AEA and 2-AG levels could be increased and unchanged, respectively, in IBD. The mRNA expression of CB1 was significantly decreased in CD and UC whilst CB2 mRNA expression was unchanged in both forms of IBD. The study demonstrated that the components of the ECS which were investigated were present in colonic tissues of both IBD patients and healthy individuals, but they appear to be off balance in CD and UC patients. The decreased CB1 receptors in IBD patients could be an important modifier in the disease and could also provide a possible pathoaetiological mechanism linking IBD and CRC. Although these findings look promising, more studies with larger sample size are required to characterise the components of the ECS in human IBD.
- Full Text:
- Date Issued: 2014
- Authors: Ababio, Frank James Kweku
- Date: 2014
- Subjects: Inflammatory bowel diseases , Gastrointestinal system , Gastrointestinal system -- Diseases
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10346 , http://hdl.handle.net/10948/d1020338
- Description: Crohn’s disease (CD) and ulcerative colitis (UC) constitute the two major forms of inflammatory bowel disease (IBD), which are disorders of chronic inflammation in the gastrointestinal tract that are associated with significant morbidity and socioeconomic burden. IBD patients with long-standing intestinal inflammation are more prone to developing colorectal cancer (CRC). Until now, none of the existing IBD treatments is able to heal the mucosal ulcerations satisfactorily. The endocannabinoid system (ECS), which comprises of endogenous cannabinoid ligands, their receptors, and metabolic enzymes, has been implicated in gut homeostasis, visceral sensation, inflammation and gastrointestinal motility. Available studies in rodent models of IBD suggest that enhancing the ECS tone may reduce inflammation and improve mucosal integrity. This evidence indicates that the components of the ECS seem well positioned to exert a protective role in IBD and also to offer a great opportunity for therapeutic exploitation. Despite the role of the ECS in the gut, the presence and function of the components of the ECS is not well characterised in human IBD. The primary aim of the study was to investigate the state of the major components of the ECS in human IBD and to establish whether IBD is associated with any changes of the components of the ECS. Cannabinoid CB1 and CB2 receptors, enzymes for endocannabinoid biosynthesis PLC, “LRAT”, NAPE-PLD and DAGL, and endocannabinoid metabolic enzymes FAAH and MAGL were analysed from colonic tissue samples of CD, UC and control patients by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) to determine the relative mRNA expression of the above genes. The RT-qPCR analysis showed that the mRNA expression of PLC, LRAT, and NAPE-PLD were unchanged in both CD and UC, whiles DAGL mRNA was decreased in UC but was unchanged in CD. The endocannabinoid degradation enzymes, FAAH mRNA expression was also unchanged in CD but decreased in UC, whereas the mRNA expression of MAGL was significantly decreased in both CD and UC. NAPE-PLD/FAAH and DAGL/MAGL ratios, an estimation of the balance of AEA and 2-AG levels, showed that AEA and 2-AG levels could be increased and unchanged, respectively, in IBD. The mRNA expression of CB1 was significantly decreased in CD and UC whilst CB2 mRNA expression was unchanged in both forms of IBD. The study demonstrated that the components of the ECS which were investigated were present in colonic tissues of both IBD patients and healthy individuals, but they appear to be off balance in CD and UC patients. The decreased CB1 receptors in IBD patients could be an important modifier in the disease and could also provide a possible pathoaetiological mechanism linking IBD and CRC. Although these findings look promising, more studies with larger sample size are required to characterise the components of the ECS in human IBD.
- Full Text:
- Date Issued: 2014
The art of addiction : a phenomenological study of the lived experiences of cocaine dependents
- Authors: Plumb, Sarah
- Date: 2009
- Subjects: Cocaine abuse , Cocaine -- Social aspects , Drugs -- Physiological effect
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9912 , http://hdl.handle.net/10948/902 , Cocaine abuse , Cocaine -- Social aspects , Drugs -- Physiological effect
- Description: Addiction is a complex social phenomenon resulting from psychological and physiological dependence. The aim of the study was to create a clinical impression of the lived experiences of cocaine dependents. A transcendental phenomenological approach was used to elicit the essence of addiction as experienced by the participants. Theoretical sampling ensured relevant participants were selected through haphazard sampling procedures. Data was collected through the use of biographical questionnaires and individual, semi-structured interviews with three cocaine dependents. Data was processed according to the four phenomenological principles epoche, phenomenological reduction, imaginative variation and synthesis using Tesch’s eight steps. The essence of cocaine dependency is contained in the psychological experiences of the drug which define and perpetuate that addiction. The psychological addiction develops prior to physical dependence resulting in an entrenched addiction before treatment is sought by the cocaine dependents.
- Full Text:
- Date Issued: 2009
- Authors: Plumb, Sarah
- Date: 2009
- Subjects: Cocaine abuse , Cocaine -- Social aspects , Drugs -- Physiological effect
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9912 , http://hdl.handle.net/10948/902 , Cocaine abuse , Cocaine -- Social aspects , Drugs -- Physiological effect
- Description: Addiction is a complex social phenomenon resulting from psychological and physiological dependence. The aim of the study was to create a clinical impression of the lived experiences of cocaine dependents. A transcendental phenomenological approach was used to elicit the essence of addiction as experienced by the participants. Theoretical sampling ensured relevant participants were selected through haphazard sampling procedures. Data was collected through the use of biographical questionnaires and individual, semi-structured interviews with three cocaine dependents. Data was processed according to the four phenomenological principles epoche, phenomenological reduction, imaginative variation and synthesis using Tesch’s eight steps. The essence of cocaine dependency is contained in the psychological experiences of the drug which define and perpetuate that addiction. The psychological addiction develops prior to physical dependence resulting in an entrenched addiction before treatment is sought by the cocaine dependents.
- Full Text:
- Date Issued: 2009
Coping and satisfaction with life of retired elderly females in a residence for the aged
- Authors: Yerushalmi, Orit
- Date: 2004
- Subjects: Older women -- South Africa -- Port Elizabeth -- Attitudes , Old age homes -- South Africa -- Port Elizabeth
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:11027 , http://hdl.handle.net/10948/383 , Older women -- South Africa -- Port Elizabeth -- Attitudes , Old age homes -- South Africa -- Port Elizabeth
- Description: Demographically the aged are the fastest growing group both world-wide and in South Africa but despite this, psychologists have neglected psycho-geriatric research and its importance. In the past, old age has been studied by psychologists as a deviation from the norm of youth. The primary focus has been on the rate of cognitive decline, the process of social withdrawal and the etiology of dementia. Although these issues are of significant importance, the positive aspects of aging should also be considered; thereby challenging the stereotype that old age means disengagement, decline and degeneration. This study aimed to explore and describe the coping and life satisfaction of the retired elderly females in a residence for the aged. A quantitative exploratory descriptive research design was employed, making use of non-probability convenience sampling. The sample consisted of 40 retired females who have been living in a residence for the aged for at least 12 months. Further inclusion criterions were that the participants should have a relatively "sound/stable" neuropsychological status (i.e., they should not be suffering from any clinically diagnosed disorders, for example, dementia and/or Alzheimer's disease). The Coping Resources Inventory (CRI) was utilized to identify the coping resources used by the participants; the Orientation to Life Questionnaire (SOC-29) was utilised as a measure of the participants' sense of coherence; the Life Satisfaction in the Elderly Scale (LSES) was employed to measure the global life satisfaction of the participants, namely on the cognitive level. A biographical questionnaire collated important demographic and background information. The data was analysed through computing descriptive statistics. Following this a Pearson product-moment correlation coefficient was utilised to inter-correlate the total score of the SOC-29 and the total score of the LSES with the individual subscales of the CRI. The results of the present study indicated the following: the SOC-29 revealed a relatively high mean score for the current sample. Results of the CRI revealed relatively high mean scores for the total scale as well as the five different subscales. The highest scores were obtained for the Spiritual/Philosophical and Physical Resources Subscales, while the lowest score was obtained for the Cognitive Resource Subscale. Results from the LSES indicated relatively high mean scores for both the total and all eight subscales. The highest scores were obtained for the Mood and xii Social contacts Subscales, while the lowest scores were obtained for the Health and Finance Subscales. Significant positive correlation was evident between the total scores of the CRI, the SOC-29 and the LSES. With regard to the individual subscales of the CRI, the results indicated significant moderate relationships between the SOC- 29 total raw score, the LSES total raw score and the Cognitive, Social and Physical Subscales scores of the CRI. However, the SOC-29 and LSES total raw scores did not correlate with the Emotional and Spiritual/Philosophical subscales of the CRI.
- Full Text:
- Date Issued: 2004
- Authors: Yerushalmi, Orit
- Date: 2004
- Subjects: Older women -- South Africa -- Port Elizabeth -- Attitudes , Old age homes -- South Africa -- Port Elizabeth
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:11027 , http://hdl.handle.net/10948/383 , Older women -- South Africa -- Port Elizabeth -- Attitudes , Old age homes -- South Africa -- Port Elizabeth
- Description: Demographically the aged are the fastest growing group both world-wide and in South Africa but despite this, psychologists have neglected psycho-geriatric research and its importance. In the past, old age has been studied by psychologists as a deviation from the norm of youth. The primary focus has been on the rate of cognitive decline, the process of social withdrawal and the etiology of dementia. Although these issues are of significant importance, the positive aspects of aging should also be considered; thereby challenging the stereotype that old age means disengagement, decline and degeneration. This study aimed to explore and describe the coping and life satisfaction of the retired elderly females in a residence for the aged. A quantitative exploratory descriptive research design was employed, making use of non-probability convenience sampling. The sample consisted of 40 retired females who have been living in a residence for the aged for at least 12 months. Further inclusion criterions were that the participants should have a relatively "sound/stable" neuropsychological status (i.e., they should not be suffering from any clinically diagnosed disorders, for example, dementia and/or Alzheimer's disease). The Coping Resources Inventory (CRI) was utilized to identify the coping resources used by the participants; the Orientation to Life Questionnaire (SOC-29) was utilised as a measure of the participants' sense of coherence; the Life Satisfaction in the Elderly Scale (LSES) was employed to measure the global life satisfaction of the participants, namely on the cognitive level. A biographical questionnaire collated important demographic and background information. The data was analysed through computing descriptive statistics. Following this a Pearson product-moment correlation coefficient was utilised to inter-correlate the total score of the SOC-29 and the total score of the LSES with the individual subscales of the CRI. The results of the present study indicated the following: the SOC-29 revealed a relatively high mean score for the current sample. Results of the CRI revealed relatively high mean scores for the total scale as well as the five different subscales. The highest scores were obtained for the Spiritual/Philosophical and Physical Resources Subscales, while the lowest score was obtained for the Cognitive Resource Subscale. Results from the LSES indicated relatively high mean scores for both the total and all eight subscales. The highest scores were obtained for the Mood and xii Social contacts Subscales, while the lowest scores were obtained for the Health and Finance Subscales. Significant positive correlation was evident between the total scores of the CRI, the SOC-29 and the LSES. With regard to the individual subscales of the CRI, the results indicated significant moderate relationships between the SOC- 29 total raw score, the LSES total raw score and the Cognitive, Social and Physical Subscales scores of the CRI. However, the SOC-29 and LSES total raw scores did not correlate with the Emotional and Spiritual/Philosophical subscales of the CRI.
- Full Text:
- Date Issued: 2004
Systemic influences on the career development of a sample of black South African adolescent females: adolescent and parental perspectives
- Stolarczyk, Elizabeth Maria, McMahon, Mary
- Authors: Stolarczyk, Elizabeth Maria , McMahon, Mary
- Date: 2016
- Subjects: Career development -- Women -- South Africa , Vocational guidance -- Women -- South Africa , Counseling -- Women -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/12865 , vital:27128
- Description: Career counselling in South Africa is yet fully support the transformation process taking place nationally. More specifically, the discipline of career psychology requires the emergence of a career development theory commensurate with its diverse population. historically, extensive use was made of western career theories which were not applicable to the majority of South Africa's culturally and ethically diverse population groups consisting predominantly of black individuals of low socioeconomic status. In addition, since 1994 a black middle class has emerged in South Africa that has become increasingly prominent. Familial and parental influence on the career development of adolescents is acknowledge as pivotal; however, little South Afriucan research exists on this topic. The aim of the present study is to investigate the systematic influence on adolescent career development from the perspectives of black South African middle class grade 11 females and their parents.
- Full Text:
- Date Issued: 2016
- Authors: Stolarczyk, Elizabeth Maria , McMahon, Mary
- Date: 2016
- Subjects: Career development -- Women -- South Africa , Vocational guidance -- Women -- South Africa , Counseling -- Women -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/12865 , vital:27128
- Description: Career counselling in South Africa is yet fully support the transformation process taking place nationally. More specifically, the discipline of career psychology requires the emergence of a career development theory commensurate with its diverse population. historically, extensive use was made of western career theories which were not applicable to the majority of South Africa's culturally and ethically diverse population groups consisting predominantly of black individuals of low socioeconomic status. In addition, since 1994 a black middle class has emerged in South Africa that has become increasingly prominent. Familial and parental influence on the career development of adolescents is acknowledge as pivotal; however, little South Afriucan research exists on this topic. The aim of the present study is to investigate the systematic influence on adolescent career development from the perspectives of black South African middle class grade 11 females and their parents.
- Full Text:
- Date Issued: 2016
Isixhosa speaking biological fathers’ perceptions and experiences of parental alienation
- Mokolobate, Motshabi Catherine
- Authors: Mokolobate, Motshabi Catherine
- Date: 2019
- Subjects: Parental alienation syndrome , Fatherhood -- Psychological aspects , Father and Child -- Psychological aspects , Parenting -- Psychological aspects
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/45053 , vital:38229
- Description: There has been a positive shift in South African laws advocating for children and father’s rights to parent-child relationships. Children often get caught in the middle of their parents’ enduring battles and acrimonious separations or divorces frequently resulting in loss of contact with one parent. The term parental alienation is used to describe this phenomenon. Parental alienation can take many forms with the common thread being the negative impact that it has on the parent-child relationship and an increase in father absenteeism. The psychological effects of absent fathers on children and single parenthood are significant and contribute to social ailments such as substance abuse, violence and abuse. Extensive research has been conducted on the effects of parental alienation on children; however, there is limited research on how fathers experience parental alienation and how it shapes their perception of fatherhood. This study aimed to explore and describe the perceptions and experiences of fathers who have experienced parental alienation. A purposive sampling method was utilized using 6 participants who were sourced from a male-focused NGO in Zwide Township in the Port Elizabeth Metropolitan area. Data was collected through in-depth semi-structured audio taped interviews. Transcribed data was analysed by means of thematic analysis following Guba’s Model of Trustworthiness as a guide for data verification. All necessary ethical considerations were adhered to. Four themes emerged from the study. Participants understood and experienced parental alienation as unjust and painful; parental alienation was perceived as complex and challenging; upbringing influenced their paternal involvement and finally parental alienation affected their perception of fatherhood and their construction of paternal identity.
- Full Text:
- Date Issued: 2019
- Authors: Mokolobate, Motshabi Catherine
- Date: 2019
- Subjects: Parental alienation syndrome , Fatherhood -- Psychological aspects , Father and Child -- Psychological aspects , Parenting -- Psychological aspects
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/45053 , vital:38229
- Description: There has been a positive shift in South African laws advocating for children and father’s rights to parent-child relationships. Children often get caught in the middle of their parents’ enduring battles and acrimonious separations or divorces frequently resulting in loss of contact with one parent. The term parental alienation is used to describe this phenomenon. Parental alienation can take many forms with the common thread being the negative impact that it has on the parent-child relationship and an increase in father absenteeism. The psychological effects of absent fathers on children and single parenthood are significant and contribute to social ailments such as substance abuse, violence and abuse. Extensive research has been conducted on the effects of parental alienation on children; however, there is limited research on how fathers experience parental alienation and how it shapes their perception of fatherhood. This study aimed to explore and describe the perceptions and experiences of fathers who have experienced parental alienation. A purposive sampling method was utilized using 6 participants who were sourced from a male-focused NGO in Zwide Township in the Port Elizabeth Metropolitan area. Data was collected through in-depth semi-structured audio taped interviews. Transcribed data was analysed by means of thematic analysis following Guba’s Model of Trustworthiness as a guide for data verification. All necessary ethical considerations were adhered to. Four themes emerged from the study. Participants understood and experienced parental alienation as unjust and painful; parental alienation was perceived as complex and challenging; upbringing influenced their paternal involvement and finally parental alienation affected their perception of fatherhood and their construction of paternal identity.
- Full Text:
- Date Issued: 2019
Index of coordination for swimming and running in triathletes: a comparative study
- Authors: Van Den Bergh, Katelyne Mei
- Date: 2020
- Subjects: Triathletes
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/46406 , vital:39598
- Description: The primary aim of this study was to compare the Index of Coordination (IdC) for both sprint and endurance swimming and running of less-skilled level triathletes. The researchutilised a quantitative approach, specifically exploratory, with a one group post-test-only research design. Twenty participants from the triathlon community, ages 18 years and older, were selected via purposive and convenient sampling. The participants were expected to complete a total of four physical tests, namely 50 m sprint swim, 1500 m endurance swim, 50 m sprint run,and 5000 m endurance run, on four separate days, over a period of two weeks. The data was collected by video recording each participant performing each of the four different tests andcoded frame-by-frame onDartfish Video Solution (10.0).The IdCwas derived by identifying the time-in markers and time-out markers for both left and right arms when swimming; and by identifying the time-on markers and time-off markers for both left and right legs when running. The results revealed significant differencesbetweenthe IdCvalues ofsprint swimming and endurance swimming(p<0.001); sprint running andendurance running(p<0.001); sprint swimming andsprint running(p<0.001); andendurance swimmingandendurance running(p<0.001).The top performersin each testwere significantly faster than bottom performers(sprint swimming: p<0.001; sprint running:p<0.001; endurance swimming: p<0.001; endurance running: p<0.001) but no significant group differences on associated IdC were found(sprint swimming: p=0.535; sprint running: p=0.857; endurance swimming: p=0.132; endurance running: p=0.775).Bothendurance tests were divided into three equal portions and it was found that 23% ofthe fastest trial endurance swim time can be explained by the IdC obtained in portion three(p=0.032); and that 62% of the fastest trial endurance run time can be explained by the IdC obtained in portion one(p<0.001). The overall findings of the study suggest that an IdC mode is considered efficient relative to the environmental contextand thatIdCis relative to skill level or alternatively independent of performance times. The IdC, therefore, remains inconclusive as an alternative method but warrants further investigation particularly in longer distance endurance events.
- Full Text:
- Date Issued: 2020
- Authors: Van Den Bergh, Katelyne Mei
- Date: 2020
- Subjects: Triathletes
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/46406 , vital:39598
- Description: The primary aim of this study was to compare the Index of Coordination (IdC) for both sprint and endurance swimming and running of less-skilled level triathletes. The researchutilised a quantitative approach, specifically exploratory, with a one group post-test-only research design. Twenty participants from the triathlon community, ages 18 years and older, were selected via purposive and convenient sampling. The participants were expected to complete a total of four physical tests, namely 50 m sprint swim, 1500 m endurance swim, 50 m sprint run,and 5000 m endurance run, on four separate days, over a period of two weeks. The data was collected by video recording each participant performing each of the four different tests andcoded frame-by-frame onDartfish Video Solution (10.0).The IdCwas derived by identifying the time-in markers and time-out markers for both left and right arms when swimming; and by identifying the time-on markers and time-off markers for both left and right legs when running. The results revealed significant differencesbetweenthe IdCvalues ofsprint swimming and endurance swimming(p<0.001); sprint running andendurance running(p<0.001); sprint swimming andsprint running(p<0.001); andendurance swimmingandendurance running(p<0.001).The top performersin each testwere significantly faster than bottom performers(sprint swimming: p<0.001; sprint running:p<0.001; endurance swimming: p<0.001; endurance running: p<0.001) but no significant group differences on associated IdC were found(sprint swimming: p=0.535; sprint running: p=0.857; endurance swimming: p=0.132; endurance running: p=0.775).Bothendurance tests were divided into three equal portions and it was found that 23% ofthe fastest trial endurance swim time can be explained by the IdC obtained in portion three(p=0.032); and that 62% of the fastest trial endurance run time can be explained by the IdC obtained in portion one(p<0.001). The overall findings of the study suggest that an IdC mode is considered efficient relative to the environmental contextand thatIdCis relative to skill level or alternatively independent of performance times. The IdC, therefore, remains inconclusive as an alternative method but warrants further investigation particularly in longer distance endurance events.
- Full Text:
- Date Issued: 2020
Identifying, recording and monitoring adverse effects associated with antriretroviral treatment
- Authors: Mulinge, Florence Muthoni
- Date: 2010
- Subjects: Highly active antiretroviral therapy , Antiretroviral agents -- South Africa -- Uitenhage , HIV infections -- Treatment -- South Africa -- Uitenhage , AIDS (Disease) -- Treatment -- South Africa -- Uitenhage
- Language: English
- Type: Thesis , Masters , MPharm
- Identifier: vital:10131 , http://hdl.handle.net/10948/1491 , Highly active antiretroviral therapy , Antiretroviral agents -- South Africa -- Uitenhage , HIV infections -- Treatment -- South Africa -- Uitenhage , AIDS (Disease) -- Treatment -- South Africa -- Uitenhage
- Description: South Africa, with an estimated 5.7 million people living with HIV, continues to have one of the largest epidemics in the world. The introduction of HAART resulted in prolonged and improved quality of life of many infected patients. However, adverse effects caused by these drugs have become a major concern as they affect the adherence of patients and in some cases even result in the death of patients. Although much research has been and is still being conducted in the area of understanding, preventing and management of ARV adverse effects, there is still a need for patients to be actively involved in self-monitoring for adverse effects. This will assist health care professionals in early identification of serious or potentially serious ARV effects. This study aimed at evaluating the usefulness of strategies developed and employed in the identification, recording and monitoring of adverse effects. The study was conducted with patients receiving HAART from a private HIV and AIDS clinic in Uitenhage, Eastern Cape, South Africa. The research project was approved by the Nelson Mandela Metropolitan University Research and Ethics Committee and the research site. This was an experimental, randomized controlled study carried out over a period of three months (August to October 2009), with a sample size of 160 patients divided into four study groups of 40 patients each. Two monitoring strategies, namely an ARV adverse effect monitoring tool and a patient self-monitoring diary were developed and used for the identification and recording of adverse effects. The four study groups included a Control group, a Tool group, a Diary group and a Tool-Diary group. Willing patients, after signing an informed consent form, were randomly assigned to one of the four groups by participating health care workers at the study site. Data was retrieved from the patient files by the researcher. Descriptive statistical analysis of the findings of the study was conducted using SPSS®. One hundred and forty nine patients were included in the final data analysis. Of the 80 diaries handed out to patients, only 33 were returned and due to errors only 31 were suitable for analysis. Monitoring tools were completed and analysed for 36 patients. The tool was found to be more effective in identifying adverse effects of a physical nature (such as peripheral neuropathy and lipodystrophy) than the usual methods of monitoring employed by the clinic, whilst the diary, used alone, was found to be less effective. Use of the tool and diary combined resulted in the most significant identification and recording of central nervous system related adverse effects and physical adverse effects. However due to the low return rate of the diaries and the majority of the monitoring tool not being completed in many instances the results of this study may not be generalisable. The study results did however suggest that combining the tool and the diary methods of adverse effect identification, yielded the most favourable results when compared to each method alone. This may be attributed to the fact that the tool is useful in identifying objective symptoms and the diaries subjective symptoms, particularly in instances where the patients forget to report their symptoms to healthcare professional whilst at the clinic. The diaries were also reported to improve adherence for more than 90 percentage (n=31) of the patients. More research would be needed in order to verify the exact significance of the tool and the diary in identifying and recording adverse effects and symptoms of adverse effects.
- Full Text:
- Date Issued: 2010
- Authors: Mulinge, Florence Muthoni
- Date: 2010
- Subjects: Highly active antiretroviral therapy , Antiretroviral agents -- South Africa -- Uitenhage , HIV infections -- Treatment -- South Africa -- Uitenhage , AIDS (Disease) -- Treatment -- South Africa -- Uitenhage
- Language: English
- Type: Thesis , Masters , MPharm
- Identifier: vital:10131 , http://hdl.handle.net/10948/1491 , Highly active antiretroviral therapy , Antiretroviral agents -- South Africa -- Uitenhage , HIV infections -- Treatment -- South Africa -- Uitenhage , AIDS (Disease) -- Treatment -- South Africa -- Uitenhage
- Description: South Africa, with an estimated 5.7 million people living with HIV, continues to have one of the largest epidemics in the world. The introduction of HAART resulted in prolonged and improved quality of life of many infected patients. However, adverse effects caused by these drugs have become a major concern as they affect the adherence of patients and in some cases even result in the death of patients. Although much research has been and is still being conducted in the area of understanding, preventing and management of ARV adverse effects, there is still a need for patients to be actively involved in self-monitoring for adverse effects. This will assist health care professionals in early identification of serious or potentially serious ARV effects. This study aimed at evaluating the usefulness of strategies developed and employed in the identification, recording and monitoring of adverse effects. The study was conducted with patients receiving HAART from a private HIV and AIDS clinic in Uitenhage, Eastern Cape, South Africa. The research project was approved by the Nelson Mandela Metropolitan University Research and Ethics Committee and the research site. This was an experimental, randomized controlled study carried out over a period of three months (August to October 2009), with a sample size of 160 patients divided into four study groups of 40 patients each. Two monitoring strategies, namely an ARV adverse effect monitoring tool and a patient self-monitoring diary were developed and used for the identification and recording of adverse effects. The four study groups included a Control group, a Tool group, a Diary group and a Tool-Diary group. Willing patients, after signing an informed consent form, were randomly assigned to one of the four groups by participating health care workers at the study site. Data was retrieved from the patient files by the researcher. Descriptive statistical analysis of the findings of the study was conducted using SPSS®. One hundred and forty nine patients were included in the final data analysis. Of the 80 diaries handed out to patients, only 33 were returned and due to errors only 31 were suitable for analysis. Monitoring tools were completed and analysed for 36 patients. The tool was found to be more effective in identifying adverse effects of a physical nature (such as peripheral neuropathy and lipodystrophy) than the usual methods of monitoring employed by the clinic, whilst the diary, used alone, was found to be less effective. Use of the tool and diary combined resulted in the most significant identification and recording of central nervous system related adverse effects and physical adverse effects. However due to the low return rate of the diaries and the majority of the monitoring tool not being completed in many instances the results of this study may not be generalisable. The study results did however suggest that combining the tool and the diary methods of adverse effect identification, yielded the most favourable results when compared to each method alone. This may be attributed to the fact that the tool is useful in identifying objective symptoms and the diaries subjective symptoms, particularly in instances where the patients forget to report their symptoms to healthcare professional whilst at the clinic. The diaries were also reported to improve adherence for more than 90 percentage (n=31) of the patients. More research would be needed in order to verify the exact significance of the tool and the diary in identifying and recording adverse effects and symptoms of adverse effects.
- Full Text:
- Date Issued: 2010
Articulating the nature of clinical nurse specialist practice
- Authors: Bell, Janet Deanne
- Date: 2015
- Subjects: Nurse practitioners , Intensive care nursing
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: vital:10057 , http://hdl.handle.net/10948/d1018623
- Description: Critical care nursing is a clinical specialist nursing practice discipline. The critical care nurse provides a constant presence in the care of a critically ill patient. She/he creates a thread of continuity in care through the myriad of other health care professionals and activities that form part of a patient’s stay in the critical care environment (World Federation of Critical Care Nurses [WFCCN], 2007). During conversations with people who have had intimate experience of the critical care environment, they have offered anecdotes that describe their interaction with critical care nurses who they perceive to be different from and better than other critical care nurses they encountered. Despite having met common professional requirements to be registered as a clinical specialist nurse, these distinctive, unique abilities that seem to be influential in meeting the complex needs and expectations of critically ill patients, their significant others as well as nursing and medical colleagues, are not displayed by all critical care nurses. While students of accredited postgraduate nursing programmes are required to advance their nursing knowledge and skill competence, many students do not seem to develop other, perhaps more tacit, qualities that utilisers characterise in their anecdotes of ‘different and better’ nursing practice. The overarching research question guiding this study was how can ‘different and better’ critical care nursing practice as recognised by a utiliser be explained? The purpose of this study was to develop an understanding of the qualities that those people who use critical care nursing practice recognise as ‘different and better’ to the norm of nursing practice they encounter in this discipline. The participant sample included patients’ significant others, nursing colleagues and medical colleagues of critical care nurses, collectively identified as utilisers. The stated aim of this work was to construct a grounded theory to elucidate an understanding of the qualities that a utiliser of critical care nursing recognises as ‘different and better’ critical care nursing practice in order to enhance the teaching and learning encounters between nurse educators and postgraduate students in learning programmes aiming to develop clinical specialist nurses. The method processes of grounded theory are designed to reveal and confirm concepts from within the data as well as the connections between these concepts, supporting the researcher in crafting a substantive theory that is definitively grounded in the participants’ views and stories (Streubert & Carpenter, 2011: 123, 128-129). Two data collection tools were employed in this study, namely in-depth unstructured individual interviews and naïve sketch. Constant comparative analysis, memo-writing, theoretical sampling, theoretical sensitivity and theoretical saturation as fundamental methods of data generation in grounded theory were applied. The study unfolded through three broad parts, namely: Forming & shaping this grounded theory through exploration and co-creation; Assimilating & situating this grounded theory through understanding and enfolding; Reflecting on this grounded theory through contemplating and reconnecting. The outcome of the first part of the study was my initial proposition of a grounded theory co-created in the interactions between the participants and myself. This was then challenged, developed and assimilated through a focussed literature review through the second part of the study. Through these two parts of this study, an inductively derived explanation was formed and shaped to produce an assimilated and situated substantive grounded theory named Being at Ease. This grounded theory articulates how ‘better and different’ nursing is recognised from the point of view of those who use the nursing ability of critical care nurses through the core concern ‘being at ease’ and its four categories ‘knowing self’, ‘skilled being’, connecting with intention’ and’ anchoring’. The final part of this study unfolded in my reflections on what this grounded theory had revealed about nurses and elements of nursing practice that are important to a utiliser in recognising ‘different and better’ critical care nursing. I suggest that as nurses we need to develop a language that enables us to reveal with clarity these intangible and tacit elements recognised within the being and doing of ‘different and better’ nursing. I reflected on the pivotal space of influence a teacher has with a student, and on how the elements essential in being and doing ‘different and better’ nursing need to be evident in her/his own ways of being a teacher of nursing. Teaching and learning encounters may be enhanced through drawing what this theory has shown as necessary elements that shape ‘different and better’ nurses through the moments of influence a teacher has in each encounter with a student.
- Full Text:
- Date Issued: 2015
- Authors: Bell, Janet Deanne
- Date: 2015
- Subjects: Nurse practitioners , Intensive care nursing
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: vital:10057 , http://hdl.handle.net/10948/d1018623
- Description: Critical care nursing is a clinical specialist nursing practice discipline. The critical care nurse provides a constant presence in the care of a critically ill patient. She/he creates a thread of continuity in care through the myriad of other health care professionals and activities that form part of a patient’s stay in the critical care environment (World Federation of Critical Care Nurses [WFCCN], 2007). During conversations with people who have had intimate experience of the critical care environment, they have offered anecdotes that describe their interaction with critical care nurses who they perceive to be different from and better than other critical care nurses they encountered. Despite having met common professional requirements to be registered as a clinical specialist nurse, these distinctive, unique abilities that seem to be influential in meeting the complex needs and expectations of critically ill patients, their significant others as well as nursing and medical colleagues, are not displayed by all critical care nurses. While students of accredited postgraduate nursing programmes are required to advance their nursing knowledge and skill competence, many students do not seem to develop other, perhaps more tacit, qualities that utilisers characterise in their anecdotes of ‘different and better’ nursing practice. The overarching research question guiding this study was how can ‘different and better’ critical care nursing practice as recognised by a utiliser be explained? The purpose of this study was to develop an understanding of the qualities that those people who use critical care nursing practice recognise as ‘different and better’ to the norm of nursing practice they encounter in this discipline. The participant sample included patients’ significant others, nursing colleagues and medical colleagues of critical care nurses, collectively identified as utilisers. The stated aim of this work was to construct a grounded theory to elucidate an understanding of the qualities that a utiliser of critical care nursing recognises as ‘different and better’ critical care nursing practice in order to enhance the teaching and learning encounters between nurse educators and postgraduate students in learning programmes aiming to develop clinical specialist nurses. The method processes of grounded theory are designed to reveal and confirm concepts from within the data as well as the connections between these concepts, supporting the researcher in crafting a substantive theory that is definitively grounded in the participants’ views and stories (Streubert & Carpenter, 2011: 123, 128-129). Two data collection tools were employed in this study, namely in-depth unstructured individual interviews and naïve sketch. Constant comparative analysis, memo-writing, theoretical sampling, theoretical sensitivity and theoretical saturation as fundamental methods of data generation in grounded theory were applied. The study unfolded through three broad parts, namely: Forming & shaping this grounded theory through exploration and co-creation; Assimilating & situating this grounded theory through understanding and enfolding; Reflecting on this grounded theory through contemplating and reconnecting. The outcome of the first part of the study was my initial proposition of a grounded theory co-created in the interactions between the participants and myself. This was then challenged, developed and assimilated through a focussed literature review through the second part of the study. Through these two parts of this study, an inductively derived explanation was formed and shaped to produce an assimilated and situated substantive grounded theory named Being at Ease. This grounded theory articulates how ‘better and different’ nursing is recognised from the point of view of those who use the nursing ability of critical care nurses through the core concern ‘being at ease’ and its four categories ‘knowing self’, ‘skilled being’, connecting with intention’ and’ anchoring’. The final part of this study unfolded in my reflections on what this grounded theory had revealed about nurses and elements of nursing practice that are important to a utiliser in recognising ‘different and better’ critical care nursing. I suggest that as nurses we need to develop a language that enables us to reveal with clarity these intangible and tacit elements recognised within the being and doing of ‘different and better’ nursing. I reflected on the pivotal space of influence a teacher has with a student, and on how the elements essential in being and doing ‘different and better’ nursing need to be evident in her/his own ways of being a teacher of nursing. Teaching and learning encounters may be enhanced through drawing what this theory has shown as necessary elements that shape ‘different and better’ nurses through the moments of influence a teacher has in each encounter with a student.
- Full Text:
- Date Issued: 2015
Bone mineral density of female long distance runners in Nelson Mandela Bay
- Authors: Meier, Catherine Anne
- Date: 2018
- Subjects: Running -- Physiological aspects , Marathon running -- South Africa -- Nelson Mandela Bay Municipality , Bones -- Metabolism , Mineral metabolism , Running -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/22946 , vital:30153
- Description: Long distance running may present positive and negative effects on the bone mineral density (BMD) of such participants. The advantage of high impact loads placed on the body of these runners may be neutralised or reversed, as too high a load may cause a decreased BMD. Furthermore, competitive female runners are generally considered to be leaner than their peers due to the nature of the sport. Therefore, it is expected that the majority of these runners would have a low body fat percentage (BF%) and body mass index (BMI) which may negatively affect the BMD, resulting in impaired bone quality. Due to the general inaccessibility of BMD assessments because of the cost involved, the incidence of risk for lowered BMD among long distance runners and particularly female runners are not readily known. The primary aim of the present study was therefore to determine the BMD rating and its association with body composition (BF% and BMI) and other selected factors among female long distance runners in Nelson Mandela Bay (NMB). The study utilized a quantitative approach and was exploratory, descriptive and non-experimental in nature. Non-probability, convenience sampling was implemented. A total of 40 female long distance runners between the age of 25 and 68 years (with a mean age of 43.6 ± 9.67 years) who have completed at least two marathon events were included in the study. The study utilized a questionnaire to collect demographic and other relevant information from the participants; a stadiometer and an electronic scale to measure height and weight and ultimately calculate BMI; and a bone densitometer with Dual-Energy X-ray Absorptiometry (DXA) (Hologic Discovery W) to determine the various BMD variables required as well as the BF%. Three densitometry scans were performed by a qualified radiographer which presented four analyses namely that of the relevant BMD variables for the hip, lumbar spine and total body, respectively, as well as of the BF% for the total body. The results of the study in respect of the overall BMD profile of the female long distance runners was considered to be normal except for the lumbar spine, found to be osteopenic when considering the mean T-score for this region of those 50 years and older. Overall the participants had an ‘average’ BF% (26.71 ± 6.33%) classification according to the ACSM classification rating system and were classified as ‘normal’ (22.80 ± 2.58 kg/m²) in respect of the BMI category rating. Significant correlations (r ≥ 0.312) were found between BMI and BMD related Z-scores for the hip, lumbar spine and total body, respectively. When considering the effect of selected variables on the various BMD variables, BF% and BMI, respectively, the following significant (p < .05; d > 0.2) results were found: (1) BMD (one or more rating and or Z-score) was positively influenced (had higher ratings) in runners who were overweight, consumed alcoholic beverages of five or less per week and who ran less than 51 km/week, respectively; (2) BMD (one or more rating and or Z-score) was negatively influenced (had lower ratings) in runners who had more full-term pregnancies and among those who were menopausal, respectively; (3) BF% and BMI were both found to be lower in runners who: were not menopausal, competed in six or more ultra-marathon events, completed marathons in less than or equal to three hours and 50 minutes, had an incidence of breaking a bone due to a traumatic event, and engaged in an average weekly running distance of more than 50 km/week, respectively.
- Full Text:
- Date Issued: 2018
- Authors: Meier, Catherine Anne
- Date: 2018
- Subjects: Running -- Physiological aspects , Marathon running -- South Africa -- Nelson Mandela Bay Municipality , Bones -- Metabolism , Mineral metabolism , Running -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/22946 , vital:30153
- Description: Long distance running may present positive and negative effects on the bone mineral density (BMD) of such participants. The advantage of high impact loads placed on the body of these runners may be neutralised or reversed, as too high a load may cause a decreased BMD. Furthermore, competitive female runners are generally considered to be leaner than their peers due to the nature of the sport. Therefore, it is expected that the majority of these runners would have a low body fat percentage (BF%) and body mass index (BMI) which may negatively affect the BMD, resulting in impaired bone quality. Due to the general inaccessibility of BMD assessments because of the cost involved, the incidence of risk for lowered BMD among long distance runners and particularly female runners are not readily known. The primary aim of the present study was therefore to determine the BMD rating and its association with body composition (BF% and BMI) and other selected factors among female long distance runners in Nelson Mandela Bay (NMB). The study utilized a quantitative approach and was exploratory, descriptive and non-experimental in nature. Non-probability, convenience sampling was implemented. A total of 40 female long distance runners between the age of 25 and 68 years (with a mean age of 43.6 ± 9.67 years) who have completed at least two marathon events were included in the study. The study utilized a questionnaire to collect demographic and other relevant information from the participants; a stadiometer and an electronic scale to measure height and weight and ultimately calculate BMI; and a bone densitometer with Dual-Energy X-ray Absorptiometry (DXA) (Hologic Discovery W) to determine the various BMD variables required as well as the BF%. Three densitometry scans were performed by a qualified radiographer which presented four analyses namely that of the relevant BMD variables for the hip, lumbar spine and total body, respectively, as well as of the BF% for the total body. The results of the study in respect of the overall BMD profile of the female long distance runners was considered to be normal except for the lumbar spine, found to be osteopenic when considering the mean T-score for this region of those 50 years and older. Overall the participants had an ‘average’ BF% (26.71 ± 6.33%) classification according to the ACSM classification rating system and were classified as ‘normal’ (22.80 ± 2.58 kg/m²) in respect of the BMI category rating. Significant correlations (r ≥ 0.312) were found between BMI and BMD related Z-scores for the hip, lumbar spine and total body, respectively. When considering the effect of selected variables on the various BMD variables, BF% and BMI, respectively, the following significant (p < .05; d > 0.2) results were found: (1) BMD (one or more rating and or Z-score) was positively influenced (had higher ratings) in runners who were overweight, consumed alcoholic beverages of five or less per week and who ran less than 51 km/week, respectively; (2) BMD (one or more rating and or Z-score) was negatively influenced (had lower ratings) in runners who had more full-term pregnancies and among those who were menopausal, respectively; (3) BF% and BMI were both found to be lower in runners who: were not menopausal, competed in six or more ultra-marathon events, completed marathons in less than or equal to three hours and 50 minutes, had an incidence of breaking a bone due to a traumatic event, and engaged in an average weekly running distance of more than 50 km/week, respectively.
- Full Text:
- Date Issued: 2018
The relationship between selected body composition components and self-efficacy among 12-14 year old rural adolescents in the Eastern Cape Province of South Africa
- Authors: Nkopo, Mandisi, S
- Date: 2017
- Subjects: Child development -- South Africa -- Eastern Cape , Children -- Growth , Body composition
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10353/4536 , vital:28403
- Description: Body composition changes drastically in both males and females during the adolescent years. The changes may have a negative effect on their physical health as well as psychological well-being, with respect to attributes such as self-efficacy. Being either overweight or obese during adolescence has social, economic and psychological consequences, which include low self-efficacy. However, very few international studies and not a single South African study could be found which measured the relationship of anthropometric body composition components, general self-efficacy levels and actual measured body size among adolescents, particularly among rural adolescents. Consequently, the aim of this study was to investigate the relationship between anthropometric body composition components and self efficacy, by conducting a comparison of self-efficacy levels among normal, overweight and obese 12 to 14-year-old rural adolescents in the Eastern Cape Province of South Africa. The sample consisted of boys (n=49) and girls (n=43) between the ages of 12 and 14 years. The body composition components were body weight, stature, body mass index, sum of 3 skinfolds, percentage body fat and hip-to-waist ratio. The sample was also classified into normal, overweight and obese groups, according to body mass index. A self-administered Self-Efficacy Questionnaire for Children (SEQ-C) which was developed by Muris (2001) was used to measure general self-efficacy. Data were analyzed by means of descriptive statistics, the Pearson correlation matrix and Cohen's effect size for significance (Cohen, 1992) and a Mann-Whitney U Test was used to determine statistical differences. Significance was set at p<0.05. Only 17 percent of the participants in the research sample were found to be overweight or obese. Only emotional self-efficacy showed significant (p=0.02) differences between the participants who were classified as having normal weights and the group which comprised the overweight and the obese groups. Overweight and obese boys and girls still had very high levels of self-efficacy, although their body mass index scores were high. Boys scored higher in social self-efficacy and girls in academic self-efficacy. Only girls presented significantly high correlations between body mass index and emotional self-efficacy (r=0.33, p=0.02), total self-efficacy and hip-to-waist ratio (r=0.44, p=0.00), social self-efficacy and hip-towaist ratio (r=0.39, p=0.01) and emotional self-efficacy and hip-to-waist ratio (r=0.33, p=0.02), while boys presented them only with respect to body weight (r=0.31, p=0.02) and stature (r=0.39, p=0.00). The results suggest that a positive relationship exists between body composition, in terms of hip-to-waist ratio, weight and stature, and self-efficacy among South African rural adolescents. However, girls presented significantly strong and positive correlations between hip-to-waist ratio and self-efficacy, whereas boys presented significant, strong and positive correlations between body weight, stature and self-efficacy. Only emotional self-efficacy showed significant differences between normal weight and overweight or obese South African rural adolescents. It seems likely that cultural beliefs may exert an influence on the psychosocial perceptions of adolescents in relation to body size, consequently affecting self efficacy levels.
- Full Text:
- Date Issued: 2017
- Authors: Nkopo, Mandisi, S
- Date: 2017
- Subjects: Child development -- South Africa -- Eastern Cape , Children -- Growth , Body composition
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10353/4536 , vital:28403
- Description: Body composition changes drastically in both males and females during the adolescent years. The changes may have a negative effect on their physical health as well as psychological well-being, with respect to attributes such as self-efficacy. Being either overweight or obese during adolescence has social, economic and psychological consequences, which include low self-efficacy. However, very few international studies and not a single South African study could be found which measured the relationship of anthropometric body composition components, general self-efficacy levels and actual measured body size among adolescents, particularly among rural adolescents. Consequently, the aim of this study was to investigate the relationship between anthropometric body composition components and self efficacy, by conducting a comparison of self-efficacy levels among normal, overweight and obese 12 to 14-year-old rural adolescents in the Eastern Cape Province of South Africa. The sample consisted of boys (n=49) and girls (n=43) between the ages of 12 and 14 years. The body composition components were body weight, stature, body mass index, sum of 3 skinfolds, percentage body fat and hip-to-waist ratio. The sample was also classified into normal, overweight and obese groups, according to body mass index. A self-administered Self-Efficacy Questionnaire for Children (SEQ-C) which was developed by Muris (2001) was used to measure general self-efficacy. Data were analyzed by means of descriptive statistics, the Pearson correlation matrix and Cohen's effect size for significance (Cohen, 1992) and a Mann-Whitney U Test was used to determine statistical differences. Significance was set at p<0.05. Only 17 percent of the participants in the research sample were found to be overweight or obese. Only emotional self-efficacy showed significant (p=0.02) differences between the participants who were classified as having normal weights and the group which comprised the overweight and the obese groups. Overweight and obese boys and girls still had very high levels of self-efficacy, although their body mass index scores were high. Boys scored higher in social self-efficacy and girls in academic self-efficacy. Only girls presented significantly high correlations between body mass index and emotional self-efficacy (r=0.33, p=0.02), total self-efficacy and hip-to-waist ratio (r=0.44, p=0.00), social self-efficacy and hip-towaist ratio (r=0.39, p=0.01) and emotional self-efficacy and hip-to-waist ratio (r=0.33, p=0.02), while boys presented them only with respect to body weight (r=0.31, p=0.02) and stature (r=0.39, p=0.00). The results suggest that a positive relationship exists between body composition, in terms of hip-to-waist ratio, weight and stature, and self-efficacy among South African rural adolescents. However, girls presented significantly strong and positive correlations between hip-to-waist ratio and self-efficacy, whereas boys presented significant, strong and positive correlations between body weight, stature and self-efficacy. Only emotional self-efficacy showed significant differences between normal weight and overweight or obese South African rural adolescents. It seems likely that cultural beliefs may exert an influence on the psychosocial perceptions of adolescents in relation to body size, consequently affecting self efficacy levels.
- Full Text:
- Date Issued: 2017
The experiences of people living with HIV-AIDS with regard to the comprehensive antiretroviral therapy management received from registered nurses at selected public primary heathcare clinics in Nelson Mandela Bay
- Authors: Jackson, Dawne Shirley
- Date: 2009
- Subjects: Antiretroviral agents -- South Africa , Stigma (Social psychology) , Nurses -- South Africa -- Attitudes , HIV-positive persons -- Counseling of -- South Africa , AIDS (Disease) -- Treatment -- South Africa , HIV infections -- Treatment -- South Africa
- Language: English
- Type: Thesis , Masters , MCur
- Identifier: vital:10032 , http://hdl.handle.net/10948/1253 , Antiretroviral agents -- South Africa , Stigma (Social psychology) , Nurses -- South Africa -- Attitudes , HIV-positive persons -- Counseling of -- South Africa , AIDS (Disease) -- Treatment -- South Africa , HIV infections -- Treatment -- South Africa
- Description: Currently South Africa has the highest number of persons living with HIV-AIDS (PLWAs) in the world. Focus-group discussions conducted by Moon (2005:3) in the Eastern Cape indicated that people may not want to get tested for HIV or to access antiretroviral therapy (ART) for fear of disclosure of their HIV-positive status and of stigmatization. These findings prompted the researcher to conduct a study in this field. The objectives of this study are to explore and describe the experiences of PLWAs with regard to the comprehensive ART management received from registered nurses at selected public primary healthcare clinics in Nelson Mandela Bay; and to develop guidelines for registered nurses that could facilitate them in rendering appropriate comprehensive ART management. The research study is based on a qualitative, explorative, descriptive, phenomenological and contextual research design. The research population comprised of HIV-positive patients who received treatment at the selected public primary healthcare clinics. Criterion-based, purposive sampling was used to select participants for the interviews. Ten in-depth unstructured interviews were conducted. Data was then transcribed and coded. One central theme identified the fact that PLWAs experienced both positive and negative experiences at the clinics. The main findings of this research included evidence of various forms of stigma experienced by the PLWAs; distrust of the lay health counselors; but also that PLWAs were generally well-treated and satisfied with the service they had received. Broad guidelines for registered nurses was formulated that could facilitate them in rendering appropriate comprehensive ART management. The study concludes with recommendations made with regards to the areas of nursing practice, education and research. Throughout the study the researcher abided by the ethical considerations. The aspects of trustworthiness implemented in this study, included dependability, credibility, transferability and confirmability (Holloway & Wheeler, 2002:354).
- Full Text:
- Date Issued: 2009
- Authors: Jackson, Dawne Shirley
- Date: 2009
- Subjects: Antiretroviral agents -- South Africa , Stigma (Social psychology) , Nurses -- South Africa -- Attitudes , HIV-positive persons -- Counseling of -- South Africa , AIDS (Disease) -- Treatment -- South Africa , HIV infections -- Treatment -- South Africa
- Language: English
- Type: Thesis , Masters , MCur
- Identifier: vital:10032 , http://hdl.handle.net/10948/1253 , Antiretroviral agents -- South Africa , Stigma (Social psychology) , Nurses -- South Africa -- Attitudes , HIV-positive persons -- Counseling of -- South Africa , AIDS (Disease) -- Treatment -- South Africa , HIV infections -- Treatment -- South Africa
- Description: Currently South Africa has the highest number of persons living with HIV-AIDS (PLWAs) in the world. Focus-group discussions conducted by Moon (2005:3) in the Eastern Cape indicated that people may not want to get tested for HIV or to access antiretroviral therapy (ART) for fear of disclosure of their HIV-positive status and of stigmatization. These findings prompted the researcher to conduct a study in this field. The objectives of this study are to explore and describe the experiences of PLWAs with regard to the comprehensive ART management received from registered nurses at selected public primary healthcare clinics in Nelson Mandela Bay; and to develop guidelines for registered nurses that could facilitate them in rendering appropriate comprehensive ART management. The research study is based on a qualitative, explorative, descriptive, phenomenological and contextual research design. The research population comprised of HIV-positive patients who received treatment at the selected public primary healthcare clinics. Criterion-based, purposive sampling was used to select participants for the interviews. Ten in-depth unstructured interviews were conducted. Data was then transcribed and coded. One central theme identified the fact that PLWAs experienced both positive and negative experiences at the clinics. The main findings of this research included evidence of various forms of stigma experienced by the PLWAs; distrust of the lay health counselors; but also that PLWAs were generally well-treated and satisfied with the service they had received. Broad guidelines for registered nurses was formulated that could facilitate them in rendering appropriate comprehensive ART management. The study concludes with recommendations made with regards to the areas of nursing practice, education and research. Throughout the study the researcher abided by the ethical considerations. The aspects of trustworthiness implemented in this study, included dependability, credibility, transferability and confirmability (Holloway & Wheeler, 2002:354).
- Full Text:
- Date Issued: 2009
A qualitative bias review of the adaptation of the WAIS-III for English-speaking South Africans
- Authors: Aston, Susan
- Date: 2006
- Subjects: Wechsler Adult Intelligence Test -- South Africa , Intelligence tests -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9939 , http://hdl.handle.net/10948/453 , http://hdl.handle.net/10948/d1011931 , Wechsler Adult Intelligence Test -- South Africa , Intelligence tests -- South Africa
- Description: In response to the growing demand for a test of cognitive ability for South African adults, the Human Sciences Research Council (HSRC) adapted the Wechsler Adult Intelligence Scales, third edition (WAIS-III) for English-speaking South Africans. However, since the publication of the South African adaptation in 2001, there has been some concern whether some bias may not still be present in the measure. Consequently, this study aimed to qualitatively explore the item content of the South African adaptation of the WAIS-III in order to identify items that might still be potentially biased with specific reference to cultural and linguistic issues. The researcher employed purposive sampling, a non-probability technique, to select psychology professionals to act as expert reviewers. The sample consisted of 20 registered psychologists, psychology lecturers and psychology interns from the predominant culture and language groups of the Eastern and Western Cape. Qualitative and quantitative data were collected by means of a Bias Review Questionnaire which consisted of fixed-choice questions, as well as sections in which specific comments could be indicated. The questionnaire was distributed to 20 selected participants who were qualified to administer psychometric measures and were registered with the Health Professionals Council of South Africa (HPCSA). Qualitative data was analysed using Tesch’s model of thematic content analysis, and five main themes relating to potential bias were identified, namely: Culture, Language, Education, Socio-economic status, and Format. The qualitative data was re-submitted to the expert review group for approval and further comment. Quantitative data obtained from the Bias Review Questionnaire was analysed by obtaining frequency counts, which were converted to percentages, per subtest and aspect reviewed. The major findings of the study were as follows: 1. Cultural bias is evident in the South African adaptation of the WAIS-III. The differential meanings ascribed to concepts, terms, phrases and words by diverse cultures impact on test performance, as does familiarity with stimulus materials used in the measure. 2. Language bias was detected against groups with English as their second or third language owing to the unfamiliar, and sometimes archaic, terms and vocabulary used in the measure. The intended meanings of the translated items are unclear and confusing for test-takers. 3. South African test-takers have experienced vastly divergent educational opportunities which impact on intelligence test performance. The measure contains potential bias against individuals from disadvantaged educational backgrounds. 4. The content of the items is not relevant to test-takers from deprived socioeconomic backgrounds that have been unable to access good-quality education. 5. Format bias was found to exist with respect to the timed tests. Cultural groups who do not value speededness are disadvantaged by the structure and format of the measure. Based on the findings of this study, certain recommendations were made. These include: 1. Additional qualitative investigation of the WAIS-III , with a view to further adaptation in an effort to eradicate bias on cultural or linguistic grounds, and 2. Conducting further Differential Item Functioning (DIF) analyses and establishing construct equivalence across cultural and linguistic groups to promote this objective. Among the contributions believed to have been made by this study are the identification of potentially biased subtests and items on the grounds of culture and language, which will facilitate possible further revision and adaptation of the measure. Additionally, the variables that were considered important influencing factors of cognitive test performance have been documented and are accessible for future research that will supplement the present study.
- Full Text:
- Date Issued: 2006
- Authors: Aston, Susan
- Date: 2006
- Subjects: Wechsler Adult Intelligence Test -- South Africa , Intelligence tests -- South Africa
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:9939 , http://hdl.handle.net/10948/453 , http://hdl.handle.net/10948/d1011931 , Wechsler Adult Intelligence Test -- South Africa , Intelligence tests -- South Africa
- Description: In response to the growing demand for a test of cognitive ability for South African adults, the Human Sciences Research Council (HSRC) adapted the Wechsler Adult Intelligence Scales, third edition (WAIS-III) for English-speaking South Africans. However, since the publication of the South African adaptation in 2001, there has been some concern whether some bias may not still be present in the measure. Consequently, this study aimed to qualitatively explore the item content of the South African adaptation of the WAIS-III in order to identify items that might still be potentially biased with specific reference to cultural and linguistic issues. The researcher employed purposive sampling, a non-probability technique, to select psychology professionals to act as expert reviewers. The sample consisted of 20 registered psychologists, psychology lecturers and psychology interns from the predominant culture and language groups of the Eastern and Western Cape. Qualitative and quantitative data were collected by means of a Bias Review Questionnaire which consisted of fixed-choice questions, as well as sections in which specific comments could be indicated. The questionnaire was distributed to 20 selected participants who were qualified to administer psychometric measures and were registered with the Health Professionals Council of South Africa (HPCSA). Qualitative data was analysed using Tesch’s model of thematic content analysis, and five main themes relating to potential bias were identified, namely: Culture, Language, Education, Socio-economic status, and Format. The qualitative data was re-submitted to the expert review group for approval and further comment. Quantitative data obtained from the Bias Review Questionnaire was analysed by obtaining frequency counts, which were converted to percentages, per subtest and aspect reviewed. The major findings of the study were as follows: 1. Cultural bias is evident in the South African adaptation of the WAIS-III. The differential meanings ascribed to concepts, terms, phrases and words by diverse cultures impact on test performance, as does familiarity with stimulus materials used in the measure. 2. Language bias was detected against groups with English as their second or third language owing to the unfamiliar, and sometimes archaic, terms and vocabulary used in the measure. The intended meanings of the translated items are unclear and confusing for test-takers. 3. South African test-takers have experienced vastly divergent educational opportunities which impact on intelligence test performance. The measure contains potential bias against individuals from disadvantaged educational backgrounds. 4. The content of the items is not relevant to test-takers from deprived socioeconomic backgrounds that have been unable to access good-quality education. 5. Format bias was found to exist with respect to the timed tests. Cultural groups who do not value speededness are disadvantaged by the structure and format of the measure. Based on the findings of this study, certain recommendations were made. These include: 1. Additional qualitative investigation of the WAIS-III , with a view to further adaptation in an effort to eradicate bias on cultural or linguistic grounds, and 2. Conducting further Differential Item Functioning (DIF) analyses and establishing construct equivalence across cultural and linguistic groups to promote this objective. Among the contributions believed to have been made by this study are the identification of potentially biased subtests and items on the grounds of culture and language, which will facilitate possible further revision and adaptation of the measure. Additionally, the variables that were considered important influencing factors of cognitive test performance have been documented and are accessible for future research that will supplement the present study.
- Full Text:
- Date Issued: 2006