Statistical model for risk diversification in renewable energy
- Authors: Ahame, Edmund
- Date: 2013
- Subjects: Renewable energy sources -- Statistics , Diversification in industry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10564 , http://hdl.handle.net/10948/d1008399 , Renewable energy sources -- Statistics , Diversification in industry
- Description: The growth of the industry and population of South Africa urges to seek new sources of electric power, hence the need to look at alternative power sources. Power output from some renewable energy sources is highly volatile. For instance power output from wind turbines or photovoltaic solar panels fluctuates between zero and the maximum rated power out. To optimize the overall power output a model was designed to determine the best trade-off between production from two or more renewable energy sources putting emphasis on wind and solar. Different measures of risk, such as coefficient of variation (CV) and value at risk (VAR), were used to determine the best hybrid renewable energy system (HRES) configuration. Depending on the investors’ expected returns (demand) and risk averseness, they will be able to use the model to choose the best configuration that suites their needs. In general it was found that investing in a diversified HRES is better than investing in individual power sources.
- Full Text:
- Date Issued: 2013
- Authors: Ahame, Edmund
- Date: 2013
- Subjects: Renewable energy sources -- Statistics , Diversification in industry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10564 , http://hdl.handle.net/10948/d1008399 , Renewable energy sources -- Statistics , Diversification in industry
- Description: The growth of the industry and population of South Africa urges to seek new sources of electric power, hence the need to look at alternative power sources. Power output from some renewable energy sources is highly volatile. For instance power output from wind turbines or photovoltaic solar panels fluctuates between zero and the maximum rated power out. To optimize the overall power output a model was designed to determine the best trade-off between production from two or more renewable energy sources putting emphasis on wind and solar. Different measures of risk, such as coefficient of variation (CV) and value at risk (VAR), were used to determine the best hybrid renewable energy system (HRES) configuration. Depending on the investors’ expected returns (demand) and risk averseness, they will be able to use the model to choose the best configuration that suites their needs. In general it was found that investing in a diversified HRES is better than investing in individual power sources.
- Full Text:
- Date Issued: 2013
Sustainable harvesting of wild populations of Cyclopia intermedia in Kouga, Eastern Cape, South Africa
- Authors: Barnardo, Nadia
- Date: 2013
- Subjects: Wild plants, Edible -- South Africa -- Eastern Cape , Rooibos tea industry -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10639 , http://hdl.handle.net/10948/d1020195
- Description: Cyclopia intermedia E. Mey is harvested from the wild to produce honeybush tea. The presence of a lignotuber and its slow growth seems to hinder the cultivation of this species and wild harvesting is likely to continue. Species distribution modelling indicated that C. intermedia has a climate envelope that spans from the Eastern Cape to the Western Cape along the Cape Fold mountains. This regional distribution is threatened under future climate change scenarios with a range loss and shift identified for climate conditions predicted for 2050. More specifically, its niche was identified as south-facing slopes with sandy to loamy sand soils and water holding capacity that is higher than the surrounding areas. Some keystone Fynbos species were found to share this niche: Leucadendron salignum, Leucospermum cuneiforme, Protea neriifolia, Protea repens, Elegia filacea and Rhodocoma fruticosa. Cyclopia intermedia grows throughout the summer with flowering buds developing in autumn. These enlarge during winter with the flowers opening in early spring. Pods develop in November and seed set occurs during December. Harvesting plants increases their fecundity with cut plants producing more than twice the number of pods and seeds compared to their non-harvested counterparts. This is because resprouting plants produce more flowering stems than uncut plants. Controlled harvesting or localised short-cycle burning could be considered as a management option to improve fecundity of declining Cyclopia intermedia populations in protected areas. C. intermedia harvesting could occur every third year and stem colour was identified as a measure of harvest maturity. Where at least 30 percent of the population has orange (RHS colour 163A) stems the population is suitable for harvesting.
- Full Text:
- Date Issued: 2013
- Authors: Barnardo, Nadia
- Date: 2013
- Subjects: Wild plants, Edible -- South Africa -- Eastern Cape , Rooibos tea industry -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10639 , http://hdl.handle.net/10948/d1020195
- Description: Cyclopia intermedia E. Mey is harvested from the wild to produce honeybush tea. The presence of a lignotuber and its slow growth seems to hinder the cultivation of this species and wild harvesting is likely to continue. Species distribution modelling indicated that C. intermedia has a climate envelope that spans from the Eastern Cape to the Western Cape along the Cape Fold mountains. This regional distribution is threatened under future climate change scenarios with a range loss and shift identified for climate conditions predicted for 2050. More specifically, its niche was identified as south-facing slopes with sandy to loamy sand soils and water holding capacity that is higher than the surrounding areas. Some keystone Fynbos species were found to share this niche: Leucadendron salignum, Leucospermum cuneiforme, Protea neriifolia, Protea repens, Elegia filacea and Rhodocoma fruticosa. Cyclopia intermedia grows throughout the summer with flowering buds developing in autumn. These enlarge during winter with the flowers opening in early spring. Pods develop in November and seed set occurs during December. Harvesting plants increases their fecundity with cut plants producing more than twice the number of pods and seeds compared to their non-harvested counterparts. This is because resprouting plants produce more flowering stems than uncut plants. Controlled harvesting or localised short-cycle burning could be considered as a management option to improve fecundity of declining Cyclopia intermedia populations in protected areas. C. intermedia harvesting could occur every third year and stem colour was identified as a measure of harvest maturity. Where at least 30 percent of the population has orange (RHS colour 163A) stems the population is suitable for harvesting.
- Full Text:
- Date Issued: 2013
The influence of soil properties on the growth and distribution of Portulacaria Afra in subtropical thicket, South Africa
- Authors: Becker, Carina Helene
- Date: 2013
- Subjects: Portulacaria afra -- South Africa , Plant conservation -- South Africa , Shrubs -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10753 , http://hdl.handle.net/10948/d1013046
- Description: Subtropical Thicket is the dominant vegetation biome in the Eastern Cape, and extends through to parts of the Western Cape. It is dominated by Portulacaria afra (spekboom), a woody succulent plant recognised for its importance as an ecosystem engineer and its carbon sequestration potential. Due to excessive grazing from domestic stock, spekboom has been completely removed from some areas. The Subtropical Thicket Restoration Programme (STRP) initiated a large scale restoration programme of planting spekboom cuttings in these degraded areas. Their efforts have been met with varying levels of success and improvement of the programme relies on continuous monitoring and scientific evaluation. I investigated the influence of selected soil properties on spekboom growth, mortality and landscape distribution, at both restoration sites and natural intact areas, and through experiments. Site or location was the most important factor influencing spekboom success at restoration plots, whereby sites in the eastern end of spekboom distribution perform better. Moving westwards slope orientation emerged as an important factor, whereby north facing slopes are preferred by spekboom. Although high levels of soil salinity (NaCl) restricted spekboom growth and affected its health, it could tolerate the levels it was exposed too. Soil pH, above 7, and phosphorous concentration, above 70 mg.kg-1, were the only limiting factors to spekboom survival found in the restoration sites. This preference for acidic soils was mirrored in intact Thicket. However in general, soil is not a major factor influencing spekboom growth and distribution, and spekboom is tolerant of a wide range of soil conditions. Spekbooms constraint is most likely a function of climate, which varies greatly across the biome. This study answered some vital questions regarding the possible influence of soil in spekboom growth and distribution. It disapproved the theory that a catena effect may be responsible for the lack of spekboom growing in bottomland areas. The study also indicates and supports the versatility of spekboom as a plant for restoring degraded lands across a range of different geologies and soil types. To maximise spekboom survival rates, restoration efforts should be focussed towards the eastern end of its distribution and to avoid planting in soils with pH levels higher than 7.
- Full Text:
- Date Issued: 2013
- Authors: Becker, Carina Helene
- Date: 2013
- Subjects: Portulacaria afra -- South Africa , Plant conservation -- South Africa , Shrubs -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10753 , http://hdl.handle.net/10948/d1013046
- Description: Subtropical Thicket is the dominant vegetation biome in the Eastern Cape, and extends through to parts of the Western Cape. It is dominated by Portulacaria afra (spekboom), a woody succulent plant recognised for its importance as an ecosystem engineer and its carbon sequestration potential. Due to excessive grazing from domestic stock, spekboom has been completely removed from some areas. The Subtropical Thicket Restoration Programme (STRP) initiated a large scale restoration programme of planting spekboom cuttings in these degraded areas. Their efforts have been met with varying levels of success and improvement of the programme relies on continuous monitoring and scientific evaluation. I investigated the influence of selected soil properties on spekboom growth, mortality and landscape distribution, at both restoration sites and natural intact areas, and through experiments. Site or location was the most important factor influencing spekboom success at restoration plots, whereby sites in the eastern end of spekboom distribution perform better. Moving westwards slope orientation emerged as an important factor, whereby north facing slopes are preferred by spekboom. Although high levels of soil salinity (NaCl) restricted spekboom growth and affected its health, it could tolerate the levels it was exposed too. Soil pH, above 7, and phosphorous concentration, above 70 mg.kg-1, were the only limiting factors to spekboom survival found in the restoration sites. This preference for acidic soils was mirrored in intact Thicket. However in general, soil is not a major factor influencing spekboom growth and distribution, and spekboom is tolerant of a wide range of soil conditions. Spekbooms constraint is most likely a function of climate, which varies greatly across the biome. This study answered some vital questions regarding the possible influence of soil in spekboom growth and distribution. It disapproved the theory that a catena effect may be responsible for the lack of spekboom growing in bottomland areas. The study also indicates and supports the versatility of spekboom as a plant for restoring degraded lands across a range of different geologies and soil types. To maximise spekboom survival rates, restoration efforts should be focussed towards the eastern end of its distribution and to avoid planting in soils with pH levels higher than 7.
- Full Text:
- Date Issued: 2013
Evaluation of eucalyptus citriodora derived p-menthane-3,8-diol-citronellal acetal as a bio-plasticizer for cosmetic application
- Authors: Burger, Kirstin
- Date: 2013
- Subjects: Plasticizers , Eucalyptus citriodora
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10420 , http://hdl.handle.net/10948/d1014080
- Description: Plasticizers are generally added to cosmetic and personal care products to improve the filmforming abilities of the product and increase flexibility of the film formed on the skin or hair surface. For example, plasticizers are present in perfumes to prolong the release of the specific scent, which is the ultimate goal in a good quality perfume. Plasticizers in nail varnishes prevent chipping, improve the aesthetics by adhering to the keratin in the nail which means the coating stays on for much longer, which is the ultimate goal in nail products. Plasticizers improve the gloss, resist chipping and allow quick drying time. Therefore it can be seen that plasticizers play a vital role in personal care products like perfumes and nail varnishes. Certain plasticizers e.g. phthalates, can cause problems associated with human health and can harm the environment. They are easily available and large volumes can be obtained at a low cost. These phthalates, for example, di-butyl phthalate (DBP) have been identified as carcinogenic. Nowadays the occurrence of cancer is rapidly increasing. The plasticizers present in a large number of consumer and personal care products, can possibly be linked to the ever increasing reports of cancer. Therefore a substitute to the traditional phthalate plasticizers must be investigated. The aim of this research is to produce a plasticizer derived from naturally occurring Eucalyptus oil, which can be used to replace the existing plasticizers in cosmetic formulations. Para-menthane-3,8-diol (PMD), occurring naturally in the oil from the tree, Eucalyptus citriodora, forms an acetal with citronellal (PMD, acetal, citronellal all occur naturally in the oil). It has been previously shown that PMD-citronellal acetal will exhibit plasticizing properties similar to conventional plasticizers. The objective was to enhance the formation of the acetal in the Eucalyptus oil by reacting it with excess PMD. An effective synthesis method for the PMD-citronellal acetal enriched oil (~73.8 percent) was determined from optimization experiments. The physical characterisation of the PMD-citronellal acetal enriched oil was done and compared with that of DBP. The acetal-enriched oil had a lower density, slightly higher solubility in water (at 25°C), lower refractive index (Brix percent) and a higher boiling point (350°C) than DBP. The physical characteristics of the Eucalyptus oil source and the acetal-enriched Eucalyptus oil were very similar. This can be expected as the Eucalyptus oil consists of ~84.3 percent Citronellal, ~ 1.3 percent PMD and 2.7 percent PMD-citronellal acetal. In this study the effectiveness of the acetal-enriched Eucalyptus oil (referred to from now on as the bio-plasticizer) was compared to a conventional plasticizer such as di-butyl phthalate (DBP), commonly used in cosmetic products. Two cosmetic formulations were produced: a nail varnish and a perfume formulation. Various tests were performed on these formulations to investigate the plasticizing properties of the bio-plasticizer. The objectives were to determine if the natural plasticizer is as effective as the potentially carcinogenic phthalate plasticizers and can be used as a substitute for the phthalates in personal care products. The results indicate that the bio-plasticizer does behave similarly to di-butyl phthalate, however, the effectiveness of the bio-plasticizer is lower than that of di-butyl phthalate. As the viscosity of the synthesized oil was high, this affected the overall consistency of the products. A more viscous nail varnish and perfume was produced in comparison to the DBP counterpart. The stability of the bio-plasticizer in the cosmetic formulations of nail varnish and perfume was also investigated. The cosmetic products were incubated at 0°C, 25°C and 40°C over a period of two months. Any changes in colour, odour, pH, refractive index, separation and plasticizer peak change in the gas chromatogram trace were recorded. It was determined that the PMD-citronellal acetal-enriched oil was relatively unstable under elevated temperatures and light intensity. Storage under higher temperatures (40°C) tends to increase the acidity. Therefore the bio-plasticizer must be placed in a closed, covered bottle and stored in an environment away from light and elevated temperatures. According to the gas chromatogram peaks, it was clear that both the bio-plasticizer and the DBP were more unstable in the perfume formulation than in the nail polish and were especially sensitive to light when in the perfume. This could possibly be due to the interaction with the fragrance molecule, p-anisaldehyde.
- Full Text:
- Date Issued: 2013
- Authors: Burger, Kirstin
- Date: 2013
- Subjects: Plasticizers , Eucalyptus citriodora
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10420 , http://hdl.handle.net/10948/d1014080
- Description: Plasticizers are generally added to cosmetic and personal care products to improve the filmforming abilities of the product and increase flexibility of the film formed on the skin or hair surface. For example, plasticizers are present in perfumes to prolong the release of the specific scent, which is the ultimate goal in a good quality perfume. Plasticizers in nail varnishes prevent chipping, improve the aesthetics by adhering to the keratin in the nail which means the coating stays on for much longer, which is the ultimate goal in nail products. Plasticizers improve the gloss, resist chipping and allow quick drying time. Therefore it can be seen that plasticizers play a vital role in personal care products like perfumes and nail varnishes. Certain plasticizers e.g. phthalates, can cause problems associated with human health and can harm the environment. They are easily available and large volumes can be obtained at a low cost. These phthalates, for example, di-butyl phthalate (DBP) have been identified as carcinogenic. Nowadays the occurrence of cancer is rapidly increasing. The plasticizers present in a large number of consumer and personal care products, can possibly be linked to the ever increasing reports of cancer. Therefore a substitute to the traditional phthalate plasticizers must be investigated. The aim of this research is to produce a plasticizer derived from naturally occurring Eucalyptus oil, which can be used to replace the existing plasticizers in cosmetic formulations. Para-menthane-3,8-diol (PMD), occurring naturally in the oil from the tree, Eucalyptus citriodora, forms an acetal with citronellal (PMD, acetal, citronellal all occur naturally in the oil). It has been previously shown that PMD-citronellal acetal will exhibit plasticizing properties similar to conventional plasticizers. The objective was to enhance the formation of the acetal in the Eucalyptus oil by reacting it with excess PMD. An effective synthesis method for the PMD-citronellal acetal enriched oil (~73.8 percent) was determined from optimization experiments. The physical characterisation of the PMD-citronellal acetal enriched oil was done and compared with that of DBP. The acetal-enriched oil had a lower density, slightly higher solubility in water (at 25°C), lower refractive index (Brix percent) and a higher boiling point (350°C) than DBP. The physical characteristics of the Eucalyptus oil source and the acetal-enriched Eucalyptus oil were very similar. This can be expected as the Eucalyptus oil consists of ~84.3 percent Citronellal, ~ 1.3 percent PMD and 2.7 percent PMD-citronellal acetal. In this study the effectiveness of the acetal-enriched Eucalyptus oil (referred to from now on as the bio-plasticizer) was compared to a conventional plasticizer such as di-butyl phthalate (DBP), commonly used in cosmetic products. Two cosmetic formulations were produced: a nail varnish and a perfume formulation. Various tests were performed on these formulations to investigate the plasticizing properties of the bio-plasticizer. The objectives were to determine if the natural plasticizer is as effective as the potentially carcinogenic phthalate plasticizers and can be used as a substitute for the phthalates in personal care products. The results indicate that the bio-plasticizer does behave similarly to di-butyl phthalate, however, the effectiveness of the bio-plasticizer is lower than that of di-butyl phthalate. As the viscosity of the synthesized oil was high, this affected the overall consistency of the products. A more viscous nail varnish and perfume was produced in comparison to the DBP counterpart. The stability of the bio-plasticizer in the cosmetic formulations of nail varnish and perfume was also investigated. The cosmetic products were incubated at 0°C, 25°C and 40°C over a period of two months. Any changes in colour, odour, pH, refractive index, separation and plasticizer peak change in the gas chromatogram trace were recorded. It was determined that the PMD-citronellal acetal-enriched oil was relatively unstable under elevated temperatures and light intensity. Storage under higher temperatures (40°C) tends to increase the acidity. Therefore the bio-plasticizer must be placed in a closed, covered bottle and stored in an environment away from light and elevated temperatures. According to the gas chromatogram peaks, it was clear that both the bio-plasticizer and the DBP were more unstable in the perfume formulation than in the nail polish and were especially sensitive to light when in the perfume. This could possibly be due to the interaction with the fragrance molecule, p-anisaldehyde.
- Full Text:
- Date Issued: 2013
Environmentally friendly dyeing and finishing
- Authors: Dayla, Mackraj
- Date: 2013
- Subjects: Dyes and dyeing -- Knit goods -- South Africa , Textile finishing -- South Africa , Bleaching industry -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10454 , http://hdl.handle.net/10948/d1020776
- Description: The textile industry in South Africa is a significant contributor to the chemical load that public wastewater treatment plants have to process, and the discharge of toxic substances, especially to the aquatic environment. In order to address this issue at factory level, the processes at a textile plant, JMV Textiles were chosen for investigation into the possibilities of minimization of discharges of harmful substances into the environment. The study followed the principles of cleaner production, and the processes that were investigated and revised were: The conventional peroxide bleaching process employed a peroxide stabilizer that did not biodegrade easily. The bleaching process was changed, so that the prevailing conditions in the fabric and dyebath facilitated bleaching without the addition of peroxide stabilizer, and also reduced the alkali and energy requirements. Polyester‐viscose fabric was pretreated by bleaching with hydrogen peroxide, which seemed to be unnecessarily rigorous, because polyester and viscose, unlike natural fibres, are relatively clean and have good whiteness in comparison with natural fibres. The proposed alternate pretreatment was a scour with detergent and alkali. The pretreatment for all polyester‐cotton fabrics was also a hydrogen peroxide bleach. Due to the ability of medium and dark shades to mask the natural tint of cotton fibres, a simpler alternate pretreatment, consisting of an alkaline scour with sequestering agent, was trialled. An unacceptable proportion of the dyeings on polyester was rejected for dye‐stains and dye‐marks. A possible solution exploited the properties of using the finishing auxiliary chemical to alleviate dye‐stains and dye‐marks during the dyeing stage, instead of using the chemical after dyeing. The highly toxic carrier that was used to facilitate level dyeing of polyester fibres that had unacceptable variation in their dyeing properties, was replaced by a less toxic carrier. The formulation for dyeing polyester was simplified to eliminate the auxiliary chemicals that were not essential to the dyeing process. Pale reactive dyed shades on cellulose and polyester‐cellulose were washed off only with hot water instead of detergent. The revised procedures consequential to the study, offered significant environmental benefits by reducing the concentration and volume of effluent produced, substituting a highly toxic carrier with a less toxic one and saving energy and water. Implementation of the suggested changes also offered financial benefits. The management of the factory, however, accepted and implemented some changes, but wanted further investigations for others and a phased approach to the other suggested changes.
- Full Text:
- Date Issued: 2013
- Authors: Dayla, Mackraj
- Date: 2013
- Subjects: Dyes and dyeing -- Knit goods -- South Africa , Textile finishing -- South Africa , Bleaching industry -- South Africa
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10454 , http://hdl.handle.net/10948/d1020776
- Description: The textile industry in South Africa is a significant contributor to the chemical load that public wastewater treatment plants have to process, and the discharge of toxic substances, especially to the aquatic environment. In order to address this issue at factory level, the processes at a textile plant, JMV Textiles were chosen for investigation into the possibilities of minimization of discharges of harmful substances into the environment. The study followed the principles of cleaner production, and the processes that were investigated and revised were: The conventional peroxide bleaching process employed a peroxide stabilizer that did not biodegrade easily. The bleaching process was changed, so that the prevailing conditions in the fabric and dyebath facilitated bleaching without the addition of peroxide stabilizer, and also reduced the alkali and energy requirements. Polyester‐viscose fabric was pretreated by bleaching with hydrogen peroxide, which seemed to be unnecessarily rigorous, because polyester and viscose, unlike natural fibres, are relatively clean and have good whiteness in comparison with natural fibres. The proposed alternate pretreatment was a scour with detergent and alkali. The pretreatment for all polyester‐cotton fabrics was also a hydrogen peroxide bleach. Due to the ability of medium and dark shades to mask the natural tint of cotton fibres, a simpler alternate pretreatment, consisting of an alkaline scour with sequestering agent, was trialled. An unacceptable proportion of the dyeings on polyester was rejected for dye‐stains and dye‐marks. A possible solution exploited the properties of using the finishing auxiliary chemical to alleviate dye‐stains and dye‐marks during the dyeing stage, instead of using the chemical after dyeing. The highly toxic carrier that was used to facilitate level dyeing of polyester fibres that had unacceptable variation in their dyeing properties, was replaced by a less toxic carrier. The formulation for dyeing polyester was simplified to eliminate the auxiliary chemicals that were not essential to the dyeing process. Pale reactive dyed shades on cellulose and polyester‐cellulose were washed off only with hot water instead of detergent. The revised procedures consequential to the study, offered significant environmental benefits by reducing the concentration and volume of effluent produced, substituting a highly toxic carrier with a less toxic one and saving energy and water. Implementation of the suggested changes also offered financial benefits. The management of the factory, however, accepted and implemented some changes, but wanted further investigations for others and a phased approach to the other suggested changes.
- Full Text:
- Date Issued: 2013
Designing multi-touch tabletop interaction techniques to support co-located Group Information Management
- Authors: Ditta, Mohammed Ali
- Date: 2013
- Subjects: Groupware (Computer software) , Teams in the workplace -- Data processing
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10493 , http://hdl.handle.net/10948/d1020639
- Description: Co-located group information management (GIM) is a form of groupware with the aim of enabling users to collaboratively find, store, maintain, organise and share personal and/or group information in support of a group activity. Existing systems aimed at partially supporting GIM activities have been implemented on single user devices. These systems make use of asynchronous communication that may hinder collaboration by misinterpretation, information leaks, etc. Few systems exist, with limited functionality, that support co-located GIM. Multi-touch tabletop interaction has given rise to a new approach for supporting Computer Supported Cooperative Work (CSCW). Multi-touch tabletops allow multiple users to naturally interact with a computer device using a shared display and gesture interaction. The tabletop environment also enables users to sit in a natural environment and synchronously communicate without bulky desktops or laptops. Multi-touch tabletops provide the hardware necessary to support co-located GIM. Existing multi-touch interaction techniques were analysed and proved insufficient to support the advanced functional requirements of GIM. The goal of this research was therefore to support co-located GIM by designing new multi-touch tabletop interaction techniques. An architecture was proposed to support co-located GIM with new multi-touch interaction techniques. A software prototype was developed based on the proposed architecture to facilitate the main activities of GIM and to collaboratively compile documents. The prototype was named CollaGIM (Colla – collaborative, GIM – group information management). CollaGIM supports the main activities of GIM using natural gesture interaction on a multi-touch tabletop. An evaluation of the software was conducted by means of a user study where 15 teams of two people participated. High task success rates and user satisfaction results were achieved, which showed that CollaGIM was capable of supporting co-located GIM using the new multi-touch tabletop interaction techniques. CollaGIM also positively supported collaboration between users.
- Full Text:
- Date Issued: 2013
- Authors: Ditta, Mohammed Ali
- Date: 2013
- Subjects: Groupware (Computer software) , Teams in the workplace -- Data processing
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10493 , http://hdl.handle.net/10948/d1020639
- Description: Co-located group information management (GIM) is a form of groupware with the aim of enabling users to collaboratively find, store, maintain, organise and share personal and/or group information in support of a group activity. Existing systems aimed at partially supporting GIM activities have been implemented on single user devices. These systems make use of asynchronous communication that may hinder collaboration by misinterpretation, information leaks, etc. Few systems exist, with limited functionality, that support co-located GIM. Multi-touch tabletop interaction has given rise to a new approach for supporting Computer Supported Cooperative Work (CSCW). Multi-touch tabletops allow multiple users to naturally interact with a computer device using a shared display and gesture interaction. The tabletop environment also enables users to sit in a natural environment and synchronously communicate without bulky desktops or laptops. Multi-touch tabletops provide the hardware necessary to support co-located GIM. Existing multi-touch interaction techniques were analysed and proved insufficient to support the advanced functional requirements of GIM. The goal of this research was therefore to support co-located GIM by designing new multi-touch tabletop interaction techniques. An architecture was proposed to support co-located GIM with new multi-touch interaction techniques. A software prototype was developed based on the proposed architecture to facilitate the main activities of GIM and to collaboratively compile documents. The prototype was named CollaGIM (Colla – collaborative, GIM – group information management). CollaGIM supports the main activities of GIM using natural gesture interaction on a multi-touch tabletop. An evaluation of the software was conducted by means of a user study where 15 teams of two people participated. High task success rates and user satisfaction results were achieved, which showed that CollaGIM was capable of supporting co-located GIM using the new multi-touch tabletop interaction techniques. CollaGIM also positively supported collaboration between users.
- Full Text:
- Date Issued: 2013
Revision of Aloiampelos Klopper & Gideon F.Sm. (xanthorrhoeaceae subfam. asphodeloideae)
- Authors: Ellis, Kristen
- Date: 2013
- Subjects: Xanthorrhoeaceae , Asparagales
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10642 , http://hdl.handle.net/10948/d1020955
- Description: The genus Aloiampelos Klopper & Gideon F.Sm., previously treated as Aloe L. Ser. Macrifoliae (Sect. Prolongatae), comprises seven species with barely succulent leaves that are popularly known as rambling, scrambling or climbing aloes, because they make use of surrounding trees and shrubs for support. The rambling aloes are centered in the Eastern Cape but some species have disjunct distributions in the Western Cape and KwaZulu-Natal. Many are widely used in gardens and landscaping. With their rambling habit and weakly succulent leaves, the genus is widely considered to be an old lineage among alooid genera. Species concepts within the genus remain contentious, with disagreement amongst taxonomists with respect to the recognition of some taxa at the rank of variety. Morphology, historical taxonomy, palynology and phylogenetics of the genus were investigated. The occasional presence of minute cilia on the sheathing leaf bases and distinct lineation of the leaf sheaths of Aloiampelos tenuior var. decidua and Aloiampelos tenuior var. rubriflora were the most important outcomes of the morphological study. The pollen grains of all species studied were very similar in grain shape and exine surface pattern, with only minor differences in grain size. Ordination analyses showed that grain length and muri length were useful at the infraspecific level, with Aloiampelos tenuior “orange” separating clearly from the other varieties. Pollen morphology was therefore not informative as a taxonomic character at species level when used in isolation, but may be useful when used in conjunction with other characteristics. Preliminary analyses of two plastid barcoding regions (matK and rbcL) and nuclear ITS have confirmed that Aloiampelos is monophyletic. These barcoding markers were not informative in assessing the species boundaries among the closely related taxa in the genus and morphological assessments were therefore used to elucidate relationships at the species rank. A key is given for the genus, integrating the findings of the study.
- Full Text:
- Date Issued: 2013
- Authors: Ellis, Kristen
- Date: 2013
- Subjects: Xanthorrhoeaceae , Asparagales
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10642 , http://hdl.handle.net/10948/d1020955
- Description: The genus Aloiampelos Klopper & Gideon F.Sm., previously treated as Aloe L. Ser. Macrifoliae (Sect. Prolongatae), comprises seven species with barely succulent leaves that are popularly known as rambling, scrambling or climbing aloes, because they make use of surrounding trees and shrubs for support. The rambling aloes are centered in the Eastern Cape but some species have disjunct distributions in the Western Cape and KwaZulu-Natal. Many are widely used in gardens and landscaping. With their rambling habit and weakly succulent leaves, the genus is widely considered to be an old lineage among alooid genera. Species concepts within the genus remain contentious, with disagreement amongst taxonomists with respect to the recognition of some taxa at the rank of variety. Morphology, historical taxonomy, palynology and phylogenetics of the genus were investigated. The occasional presence of minute cilia on the sheathing leaf bases and distinct lineation of the leaf sheaths of Aloiampelos tenuior var. decidua and Aloiampelos tenuior var. rubriflora were the most important outcomes of the morphological study. The pollen grains of all species studied were very similar in grain shape and exine surface pattern, with only minor differences in grain size. Ordination analyses showed that grain length and muri length were useful at the infraspecific level, with Aloiampelos tenuior “orange” separating clearly from the other varieties. Pollen morphology was therefore not informative as a taxonomic character at species level when used in isolation, but may be useful when used in conjunction with other characteristics. Preliminary analyses of two plastid barcoding regions (matK and rbcL) and nuclear ITS have confirmed that Aloiampelos is monophyletic. These barcoding markers were not informative in assessing the species boundaries among the closely related taxa in the genus and morphological assessments were therefore used to elucidate relationships at the species rank. A key is given for the genus, integrating the findings of the study.
- Full Text:
- Date Issued: 2013
Propagating some commonly-used South African medicinal plants with compost and vermitea
- Authors: Faulconbridge, Steven Craig
- Date: 2013
- Subjects: Medicinal plants -- Propagation -- South Africa , Compost -- South Africa
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:10736 , http://hdl.handle.net/10948/d1020316
- Description: The use of many of South Africa’s medicinal plants has shown marked increase with over 27 million users in South Africa alone. Most plants are still being unsustainably wild-harvested, a major concern for biodiversity conservation. Commercial interest in certain more commonly-used species has increased, with potential to cultivate medicinal plants on a more sustainable basis. Focus has shifted from conventional use of synthetic fertilisers, pesticides and fungicides to more organic methods of plant propagation. Aqueous extract derived from earthworm composted food waste (vermitea) was used to study the germination and rooting success of selected species. Also survival and growth performance of selected plants grown in a medium amended with commercial NPK fertiliser was compared to those grown in the same medium amended with compost and to those grown in the same medium amended with compost with weekly applications of vermitea. No change in germination success was noted. Vermitea showed promising results on the rooting of cuttings. The application of NPK improved growth performance (biomass) significantly for all species tested. However, they had lower root:shoot ratios as well as lower survival rates compared to plants under the compost and compost/vermitea treatments. The improved survival of these plants highlights the potential of these organic treatments on the propagation of selected medicinal plants.
- Full Text:
- Date Issued: 2013
- Authors: Faulconbridge, Steven Craig
- Date: 2013
- Subjects: Medicinal plants -- Propagation -- South Africa , Compost -- South Africa
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:10736 , http://hdl.handle.net/10948/d1020316
- Description: The use of many of South Africa’s medicinal plants has shown marked increase with over 27 million users in South Africa alone. Most plants are still being unsustainably wild-harvested, a major concern for biodiversity conservation. Commercial interest in certain more commonly-used species has increased, with potential to cultivate medicinal plants on a more sustainable basis. Focus has shifted from conventional use of synthetic fertilisers, pesticides and fungicides to more organic methods of plant propagation. Aqueous extract derived from earthworm composted food waste (vermitea) was used to study the germination and rooting success of selected species. Also survival and growth performance of selected plants grown in a medium amended with commercial NPK fertiliser was compared to those grown in the same medium amended with compost and to those grown in the same medium amended with compost with weekly applications of vermitea. No change in germination success was noted. Vermitea showed promising results on the rooting of cuttings. The application of NPK improved growth performance (biomass) significantly for all species tested. However, they had lower root:shoot ratios as well as lower survival rates compared to plants under the compost and compost/vermitea treatments. The improved survival of these plants highlights the potential of these organic treatments on the propagation of selected medicinal plants.
- Full Text:
- Date Issued: 2013
Development and validation of in-process control test kits for biodiesel production
- Authors: Fibi, Pumza Oscarine
- Date: 2013
- Subjects: Biodiesel fuels -- South Africa , Biomass energy -- South Africa
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:10416 , http://hdl.handle.net/10948/d1012645 , Biodiesel fuels -- South Africa , Biomass energy -- South Africa
- Description: The production of biodiesel from vegetable oils is not a new technology; it has been around since the 1950’s and both the research in terms of the different feedstock that can be used and the production of biodiesel has since been gaining momentum as there needs to be a new, sustainable and domestic alternative to petroleum fuels. These petroleum fuels pose enormous threats to the environment and therefore need to be replaced as they are mostly contributing to climate change and global warming not to mention the frequent price hikes which are crippling the South African economy. Biodiesel production using vegetable oils seems to be and is the future and a law has recently been passed which sanctions the production of biofuel locally.[1] South African fuel producers will instigate obligatory blending of fossil fuel with biofuel as the country moves to encourage investment in its biofuels sector. The production of biodiesel locally and the blending of biodiesel with other petroleum products will reduce the country’s dependence on imported fuel. The already established petrochemical companies like BP, Sasol and Engine are therefore mandated to purchase these biofuels if and when the biofuels meet the required South African National Standard (SANS) 1935 requirements. This is then where the challenge comes as most of these growing biofuel companies cannot afford to purchase testing equipment.The growing companiesthen discover upon completion of the biofuel manufacturing process that their product does not meet the required standard specification. The failure translates to a financial loss as the final product can possibly not be reworked. The aim of the project is then to assist these companies who are manufacturing biofuel, by providing them with in-house biofuel process methods which will allow for early detection, should there be a need to redo a step in the process and not wait until the completion of the production process. These in-house process-testing methods will range from pH determination, titration tests which will determine the soap content and the percentage free fatty acid content, water determination, density and visual testing. It is not cost-effective for these biodiesel manufacturers to send their samples for outsource testing as evidently the results obtained would be out of specification hence the need to provide these biodiesel manufacturers with in-house analytical testing techniques that will aid in monitoring of the biodiesel production.
- Full Text:
- Date Issued: 2013
- Authors: Fibi, Pumza Oscarine
- Date: 2013
- Subjects: Biodiesel fuels -- South Africa , Biomass energy -- South Africa
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:10416 , http://hdl.handle.net/10948/d1012645 , Biodiesel fuels -- South Africa , Biomass energy -- South Africa
- Description: The production of biodiesel from vegetable oils is not a new technology; it has been around since the 1950’s and both the research in terms of the different feedstock that can be used and the production of biodiesel has since been gaining momentum as there needs to be a new, sustainable and domestic alternative to petroleum fuels. These petroleum fuels pose enormous threats to the environment and therefore need to be replaced as they are mostly contributing to climate change and global warming not to mention the frequent price hikes which are crippling the South African economy. Biodiesel production using vegetable oils seems to be and is the future and a law has recently been passed which sanctions the production of biofuel locally.[1] South African fuel producers will instigate obligatory blending of fossil fuel with biofuel as the country moves to encourage investment in its biofuels sector. The production of biodiesel locally and the blending of biodiesel with other petroleum products will reduce the country’s dependence on imported fuel. The already established petrochemical companies like BP, Sasol and Engine are therefore mandated to purchase these biofuels if and when the biofuels meet the required South African National Standard (SANS) 1935 requirements. This is then where the challenge comes as most of these growing biofuel companies cannot afford to purchase testing equipment.The growing companiesthen discover upon completion of the biofuel manufacturing process that their product does not meet the required standard specification. The failure translates to a financial loss as the final product can possibly not be reworked. The aim of the project is then to assist these companies who are manufacturing biofuel, by providing them with in-house biofuel process methods which will allow for early detection, should there be a need to redo a step in the process and not wait until the completion of the production process. These in-house process-testing methods will range from pH determination, titration tests which will determine the soap content and the percentage free fatty acid content, water determination, density and visual testing. It is not cost-effective for these biodiesel manufacturers to send their samples for outsource testing as evidently the results obtained would be out of specification hence the need to provide these biodiesel manufacturers with in-house analytical testing techniques that will aid in monitoring of the biodiesel production.
- Full Text:
- Date Issued: 2013
The medicinal plant Sutherlandia Frutescens regulates gene expression to reverse insulin resistace in rats
- Authors: Fortuin, Melissa
- Date: 2013
- Subjects: Insulin resistance , Medicinal plants , Genetic regulation , Insulin resistance -- Animal models
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10349 , http://hdl.handle.net/10948/d1020823
- Description: Obesity can lead to Type 2 Diabetes, both conditions increase in association with physical inactivity and high-energy diets, resulting in elevated blood glucose, decreased insulin sensitivity and increased insulin resistance. Sutherlandia frutescens (S.frutescens), an anti-diabetic plant, reverses and prevents insulin resistance in a rat model and human cell culture model. Gene expression analysis in hepatocyte cultures, identified genes down regulated in insulin resistance and up regulated by S.frutescens. These included genes encoding vesicle transporter proteins, hypothesised to be linked to hepatic lipid accumulation and lipid droplet formation during insulin resistance. The aim of this study was to investigate critical genes involved in lipid droplet formation, vesicle assembly and transport in high fat diet (HFD)-induced insulin resistant rat liver tissue during the development of insulin resistance and the reversal of these changes by S.frutescens. Rats were fed a low fat diet (LFD) or HFD supplemented with S.frutescens for 2, 4 and 8 weeks. Rats fed a HFD for 12 weeks developed insulin resistance, confirmed by plasma glucose and insulin levels (compared to normal controls). Groups of these rats were gavaged with S. frutescens (50mg/kg BW), Metformin (13mg/kg BW) or water for a further 4 weeks and starved for 12 hours, anaesthetized and blood removed by heart puncture. Liver was stored in RNA-Later™ for qRT-PCR and snap-frozen in liquid nitrogen for western blotting and confocal microscopy analysis. Changes in expression of vesicle transporter genes VAMP3 and NSF were analysed by qRT-PCR and changes in the protein expression by western blotting analysis. Proteins were localised within the liver by confocal immunohistochemistry using ZEN lite™ software. Statistical analysis was performed using One-Way ANOVA and unpaired t-test. mRNA gene expression of vesicle transport components VAMP3, NSF and SNAP25 showed relatively moderate changes with considerable individual variation within control or experimental groups. Uncorrelated changes in mRNA and protein products were found and may be due to differential regulation by siRNA. Proteins also showed altered staining patterns in high fat diet rats that reverted towards normal on S. frutescens treatment, potentially reflecting functional changes associated with transport of lipid-filled vesicles.
- Full Text:
- Date Issued: 2013
- Authors: Fortuin, Melissa
- Date: 2013
- Subjects: Insulin resistance , Medicinal plants , Genetic regulation , Insulin resistance -- Animal models
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10349 , http://hdl.handle.net/10948/d1020823
- Description: Obesity can lead to Type 2 Diabetes, both conditions increase in association with physical inactivity and high-energy diets, resulting in elevated blood glucose, decreased insulin sensitivity and increased insulin resistance. Sutherlandia frutescens (S.frutescens), an anti-diabetic plant, reverses and prevents insulin resistance in a rat model and human cell culture model. Gene expression analysis in hepatocyte cultures, identified genes down regulated in insulin resistance and up regulated by S.frutescens. These included genes encoding vesicle transporter proteins, hypothesised to be linked to hepatic lipid accumulation and lipid droplet formation during insulin resistance. The aim of this study was to investigate critical genes involved in lipid droplet formation, vesicle assembly and transport in high fat diet (HFD)-induced insulin resistant rat liver tissue during the development of insulin resistance and the reversal of these changes by S.frutescens. Rats were fed a low fat diet (LFD) or HFD supplemented with S.frutescens for 2, 4 and 8 weeks. Rats fed a HFD for 12 weeks developed insulin resistance, confirmed by plasma glucose and insulin levels (compared to normal controls). Groups of these rats were gavaged with S. frutescens (50mg/kg BW), Metformin (13mg/kg BW) or water for a further 4 weeks and starved for 12 hours, anaesthetized and blood removed by heart puncture. Liver was stored in RNA-Later™ for qRT-PCR and snap-frozen in liquid nitrogen for western blotting and confocal microscopy analysis. Changes in expression of vesicle transporter genes VAMP3 and NSF were analysed by qRT-PCR and changes in the protein expression by western blotting analysis. Proteins were localised within the liver by confocal immunohistochemistry using ZEN lite™ software. Statistical analysis was performed using One-Way ANOVA and unpaired t-test. mRNA gene expression of vesicle transport components VAMP3, NSF and SNAP25 showed relatively moderate changes with considerable individual variation within control or experimental groups. Uncorrelated changes in mRNA and protein products were found and may be due to differential regulation by siRNA. Proteins also showed altered staining patterns in high fat diet rats that reverted towards normal on S. frutescens treatment, potentially reflecting functional changes associated with transport of lipid-filled vesicles.
- Full Text:
- Date Issued: 2013
Single-end reflectometric measurements of polarization-mode dispersion in single-mode optical fibres
- Authors: Fosuhene, Samuel Kofi
- Date: 2013
- Subjects: Fiber optics , Polarization (Light) , Optical measurements
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/6280 , vital:21069
- Description: In this thesis two novel single-end methods are applied to measure and characterize polarization mode dispersion in single mode optical fibres. Polarization mode dispersion (PMD) is an important factor negatively affecting the successful implementation of high speed long haul optical fibre networks operating at bit rates of 10Gb/s and above. PMD measurements are thus important for quality control during manufacturing and cabling processes. It is also useful for network operators planning to upgrade bitrates in existing networks to 10Gb/s and beyond. In an optical fibre link, sections with particularly high PMD may act to increase the entire PMD of the link. Identifying and replacing such sections can greatly reduce the PMD of the link. PMD measurements can be forward or single-end. In forward measurements, both ends of the fibre are used for input and detection. In single-end configuration, only one end of the fibre is used. For this reason, single-end measurements are more practical for the field where fibre ends are situated several kilometres apart. Single-end techniques can be implemented with a continuous wave for non-local PMD measurements (by Fresnel reflection). If a pulsed wave is used, local measurements can be achieved (by total power due to Rayleigh scattering). Two single-end schemes, one based on Fresnel reflection and the other due to Rayleigh scattering have been applied to measure non-local and local PMD of standard single mode optical fibres. For the non-local PMD measurements, the general interferometric technique (GINTY) was modified to operate in a round-trip configuration. In this configuration, the fibre was treated as a concatenation of two identical fibre segments. Three different sets of fibres were investigated, each set representing a particular mode coupling regime. For polarization maintaining fibres, (PMFs), with no mode coupling, a factor of two was found between forward and single-end measurements. For long single mode fibres in the long length regime, the factor was 1.4. For a combination of PMF and single mode fibres, a factor of 1.6 was obtained. The method which is accurate, repeatable, low cost and robust is very suitable for field applications. The second method is the polarization optical time domain reflectometric (P-OTDR) technique. This technique performs local birefringence measurements by measuring the evolution of the states of polarization (SOP). The birefringence information from such measurements was extracted and analysed to characterise four different fibres. Beat lengths and correlation lengths extracted from the P-OTDR were used to calculate the differential group delay (DGD) of the fibres. Next an expression for the root-mean-square differential group delay was derived and applied to the birefringence measurements to calculate the DGDs at a single wavelength. This method which operates at a single wavelength has a huge advantage. Firstly it is able to measure completely all the fibre characteristic parameters. Secondly it can measure mean DGD, root mean square DGD and instantaneous DGD. A plot of instantaneous DGD vs. length enables one to identify and eliminate sections with particularly high DGD. Finally since the P-OTDR system operates with a single wavelength, real time monitoring of PMD is possible via multiplexing. The results obtained are repeatable, accurate and are in good agreement with the standard Jones Matrix Eigenanalysis (JME) technique.
- Full Text:
- Date Issued: 2013
Single-end reflectometric measurements of polarization-mode dispersion in single-mode optical fibres
- Authors: Fosuhene, Samuel Kofi
- Date: 2013
- Subjects: Fiber optics , Polarization (Light) , Optical measurements
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/6280 , vital:21069
- Description: In this thesis two novel single-end methods are applied to measure and characterize polarization mode dispersion in single mode optical fibres. Polarization mode dispersion (PMD) is an important factor negatively affecting the successful implementation of high speed long haul optical fibre networks operating at bit rates of 10Gb/s and above. PMD measurements are thus important for quality control during manufacturing and cabling processes. It is also useful for network operators planning to upgrade bitrates in existing networks to 10Gb/s and beyond. In an optical fibre link, sections with particularly high PMD may act to increase the entire PMD of the link. Identifying and replacing such sections can greatly reduce the PMD of the link. PMD measurements can be forward or single-end. In forward measurements, both ends of the fibre are used for input and detection. In single-end configuration, only one end of the fibre is used. For this reason, single-end measurements are more practical for the field where fibre ends are situated several kilometres apart. Single-end techniques can be implemented with a continuous wave for non-local PMD measurements (by Fresnel reflection). If a pulsed wave is used, local measurements can be achieved (by total power due to Rayleigh scattering). Two single-end schemes, one based on Fresnel reflection and the other due to Rayleigh scattering have been applied to measure non-local and local PMD of standard single mode optical fibres. For the non-local PMD measurements, the general interferometric technique (GINTY) was modified to operate in a round-trip configuration. In this configuration, the fibre was treated as a concatenation of two identical fibre segments. Three different sets of fibres were investigated, each set representing a particular mode coupling regime. For polarization maintaining fibres, (PMFs), with no mode coupling, a factor of two was found between forward and single-end measurements. For long single mode fibres in the long length regime, the factor was 1.4. For a combination of PMF and single mode fibres, a factor of 1.6 was obtained. The method which is accurate, repeatable, low cost and robust is very suitable for field applications. The second method is the polarization optical time domain reflectometric (P-OTDR) technique. This technique performs local birefringence measurements by measuring the evolution of the states of polarization (SOP). The birefringence information from such measurements was extracted and analysed to characterise four different fibres. Beat lengths and correlation lengths extracted from the P-OTDR were used to calculate the differential group delay (DGD) of the fibres. Next an expression for the root-mean-square differential group delay was derived and applied to the birefringence measurements to calculate the DGDs at a single wavelength. This method which operates at a single wavelength has a huge advantage. Firstly it is able to measure completely all the fibre characteristic parameters. Secondly it can measure mean DGD, root mean square DGD and instantaneous DGD. A plot of instantaneous DGD vs. length enables one to identify and eliminate sections with particularly high DGD. Finally since the P-OTDR system operates with a single wavelength, real time monitoring of PMD is possible via multiplexing. The results obtained are repeatable, accurate and are in good agreement with the standard Jones Matrix Eigenanalysis (JME) technique.
- Full Text:
- Date Issued: 2013
Molecular signaling in colorectal carcinogenesis : the roles and relationships of beta-catenin, PPARgamma and COX-2
- Authors: Fredericks, Ernst
- Date: 2013
- Subjects: Colon (Anatomy) -- Cancer , Cyclooxygenase 2 , Peroxisomes
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10357 , http://hdl.handle.net/10948/d1021014
- Description: Colorectal cancer (CRC) is a common disease with significant morbidity and mortality. In spite of significant advances in understanding the molecular signaling in this disorder, unanswered questions remain. Cyclooxygenase-2 (COX-2) and β-catenin have established roles in colorectal carcinogenesis, with both being upregulated early in the disease course. The role of peroxisome proliferator-activated receptor γ (PPARγ) is less clear, but has been shown to be downregulated in colon cancer models. Butyrate, a short chain fatty acid, produced by colon microbiota and transported into the colonocyte by transporter proteins, appears to be important in early carcinogenesis. The butyrate concentration is reduced in CRC and so are its transporters. Interleukin-17 (IL-17) plays a role in colitis-associated colorectal cancer (CAC), but its function in sporadic CRC is less clear. Similarly, Protein kinase C (PKC) has proven involvement in many solid tumours, including CRC, but its exact mechanistic role is still speculative. AIM: To investigate the role and possible signaling pathways of the major role players, β-catenin, COX-2 and PPARγ in early CRC. Further, to elucidate the mechanistic pathways of butyrate and its transporters, IL-17 and PKC in CRC. METHOD: Informed consent was obtained for all patients. Patients were recruited in various disease categories, including normal, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and CRC. Colon biopsy specimens were obtained during colonoscopy and used for immunohistochemistry (IHC) and gene expression analysis of the above genes by quantitative polymerase chain reaction (qPCR). RESULTS: β-catenin mRNA and protein expression was increased in CRC and the IBD groups compared to the normal group, while it was reduced in the IBS groups. COX-2 mRNA expression showed a steady increase from normal, through IBS, IBD and CRC groups to a statistically significant degree. The COX-2 protein expression, however, did not match the mRNA expression with increased COX-2 protein expression in normal and IBS groups and reduced expression in IBD and CRC groups. PPARγ mRNA expression was unchanged in IBD and CRC groups, but significantly increased in the IBS group compared to normal. Butyrate transporter, SLC16A1 mRNA was significantly reduced in CRC, but also in the IBS groups, which was unexpected. In the IBD group, SLC16A1 mRNA was unchanged in Crohn’s disease (CD) but significantly reduced in ulcerative colitis (UC). Similarly, SLC5A8 mRNA expression was significantly reduced in the CRC as well as the IBS groups. In the IBD groups, SLC5A8 was unchanged in UC but significantly increased in CD. IL-17 mRNA expression was significantly reduced in CRC and IBS groups, but unchanged in the IBD groups. PKCε mRNA was significantly increased in CRC as expected. In the IBD groups, PKCε mRNA was unchanged in CD but significantly increased in UC. In the IBS groups, PKCε mRNA in constipation –IBS (C-IBS) was significantly reduced, but unchanged in diarrhoea – IBS (D-IBS). CONCLUSIONS: β-catenin mRNA and protein expression was increased in CRC and the CRC promoting IBD groups. COX-2 protein expression was incongruent with the COX-2 mRNA expression and this may reflect homeostatic control mechanisms. High COX-2 mRNA expression in CRC and CRC promoting IBD groups may be a secondary phenomenon reflecting the inflammatory milieu, rather than a true carcinogenesis-related event. PPARγ does not appear to play a central role in early colon carcinogenesis, in spite of available literature suggesting otherwise. Butyrate transporters showed inconsistent results and for now no firm conclusions can be drawn from this. IL-17 may play a role in CAC as confirmed in this and other studies, but its role in sporadic CRC is tenuous and requires further investigation. Likewise for PKCε, upregulation is associated with increased tumourigenecity as shown in this study, however, the mechanistic pathway(s) involved is still speculative and requires further study.
- Full Text:
- Date Issued: 2013
- Authors: Fredericks, Ernst
- Date: 2013
- Subjects: Colon (Anatomy) -- Cancer , Cyclooxygenase 2 , Peroxisomes
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10357 , http://hdl.handle.net/10948/d1021014
- Description: Colorectal cancer (CRC) is a common disease with significant morbidity and mortality. In spite of significant advances in understanding the molecular signaling in this disorder, unanswered questions remain. Cyclooxygenase-2 (COX-2) and β-catenin have established roles in colorectal carcinogenesis, with both being upregulated early in the disease course. The role of peroxisome proliferator-activated receptor γ (PPARγ) is less clear, but has been shown to be downregulated in colon cancer models. Butyrate, a short chain fatty acid, produced by colon microbiota and transported into the colonocyte by transporter proteins, appears to be important in early carcinogenesis. The butyrate concentration is reduced in CRC and so are its transporters. Interleukin-17 (IL-17) plays a role in colitis-associated colorectal cancer (CAC), but its function in sporadic CRC is less clear. Similarly, Protein kinase C (PKC) has proven involvement in many solid tumours, including CRC, but its exact mechanistic role is still speculative. AIM: To investigate the role and possible signaling pathways of the major role players, β-catenin, COX-2 and PPARγ in early CRC. Further, to elucidate the mechanistic pathways of butyrate and its transporters, IL-17 and PKC in CRC. METHOD: Informed consent was obtained for all patients. Patients were recruited in various disease categories, including normal, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD) and CRC. Colon biopsy specimens were obtained during colonoscopy and used for immunohistochemistry (IHC) and gene expression analysis of the above genes by quantitative polymerase chain reaction (qPCR). RESULTS: β-catenin mRNA and protein expression was increased in CRC and the IBD groups compared to the normal group, while it was reduced in the IBS groups. COX-2 mRNA expression showed a steady increase from normal, through IBS, IBD and CRC groups to a statistically significant degree. The COX-2 protein expression, however, did not match the mRNA expression with increased COX-2 protein expression in normal and IBS groups and reduced expression in IBD and CRC groups. PPARγ mRNA expression was unchanged in IBD and CRC groups, but significantly increased in the IBS group compared to normal. Butyrate transporter, SLC16A1 mRNA was significantly reduced in CRC, but also in the IBS groups, which was unexpected. In the IBD group, SLC16A1 mRNA was unchanged in Crohn’s disease (CD) but significantly reduced in ulcerative colitis (UC). Similarly, SLC5A8 mRNA expression was significantly reduced in the CRC as well as the IBS groups. In the IBD groups, SLC5A8 was unchanged in UC but significantly increased in CD. IL-17 mRNA expression was significantly reduced in CRC and IBS groups, but unchanged in the IBD groups. PKCε mRNA was significantly increased in CRC as expected. In the IBD groups, PKCε mRNA was unchanged in CD but significantly increased in UC. In the IBS groups, PKCε mRNA in constipation –IBS (C-IBS) was significantly reduced, but unchanged in diarrhoea – IBS (D-IBS). CONCLUSIONS: β-catenin mRNA and protein expression was increased in CRC and the CRC promoting IBD groups. COX-2 protein expression was incongruent with the COX-2 mRNA expression and this may reflect homeostatic control mechanisms. High COX-2 mRNA expression in CRC and CRC promoting IBD groups may be a secondary phenomenon reflecting the inflammatory milieu, rather than a true carcinogenesis-related event. PPARγ does not appear to play a central role in early colon carcinogenesis, in spite of available literature suggesting otherwise. Butyrate transporters showed inconsistent results and for now no firm conclusions can be drawn from this. IL-17 may play a role in CAC as confirmed in this and other studies, but its role in sporadic CRC is tenuous and requires further investigation. Likewise for PKCε, upregulation is associated with increased tumourigenecity as shown in this study, however, the mechanistic pathway(s) involved is still speculative and requires further study.
- Full Text:
- Date Issued: 2013
Nonlinear effects with a focus on cross phase modulation and its impact on wavelength division multiplexing optical fibre networks
- Gamatham, Romeo Reginald Gunther
- Authors: Gamatham, Romeo Reginald Gunther
- Date: 2013
- Subjects: Wavelength division multiplexing , Optical communications , Fiber optics
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/6302 , vital:21071
- Description: The demand for faster data transmission is ever increasing. Wavelength division multiplexing (WDM) presents as a viable solution to increase the data transmission rate significantly. WDM systems are based on the ability to transmit multiple wavelengths simultaneously down the fibre. Unlike time division multiplexing (TDM) systems, WDM systems do not increase the data transfer by increasing the transmission rate of a single channel. In WDM systems the data rate per channel remains the same, only multiple channels carry data across the link. Dense wavelength division multiplexing (DWDM) promises even more wavelengths packed together in the same fibre. This multiplication of channels increases the bandwidth capacity rapidly. Networks are looking into making use of technology that will ensure no electronic signal regeneration at any point within the DWDM network. Examples are; reconfigurable optical add/drop multiplexers (ROADM) and optical cross connect (OXC) units. These components essentially enable network operators to split, combine and multiplex optical signals carried by optical fibre. WDM allows network operators to increase the capacity of existing networks without expensive re-cabling. This provides networks with the flexibility to be upgraded to larger bandwidths and for reconfiguration of network services. Further, WDM technology opens up an opportunity of marketing flexibility to network operators, where operators not only have the option to rent out cables and fibres but wavelengths as well. Cross phase modulation (XPM) poses a problem to WDM networks. The refractive index experienced by a neighbouring optical signal, not only depends on the signal’s intensity but on the intensity of the co-propagating signal as well. This effect leads to a phase change and is known as XPM. This work investigates the characteristics of XPM. It is shown that, in a two channel WDM network, a probe signal’s SOP can be steered by controlling a high intensity pump signal’s SOP. This effect could be applied to make a wavelength converter. Experimental results show that the degree of polarization (DOP) of a probe signal degrades according to a mathematical model found in literature. The pump and probe signals are shown to experience maximum interaction, for orthogonal probe-pump SOP vector orientations. This may be problematic to polarization mode dispersion compensators. Additionally, experimental results point out that the SOP of a probe signal is much more active in the presence of a high intensity pump, as compared to the single signal transmission scenario.
- Full Text:
- Date Issued: 2013
- Authors: Gamatham, Romeo Reginald Gunther
- Date: 2013
- Subjects: Wavelength division multiplexing , Optical communications , Fiber optics
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/6302 , vital:21071
- Description: The demand for faster data transmission is ever increasing. Wavelength division multiplexing (WDM) presents as a viable solution to increase the data transmission rate significantly. WDM systems are based on the ability to transmit multiple wavelengths simultaneously down the fibre. Unlike time division multiplexing (TDM) systems, WDM systems do not increase the data transfer by increasing the transmission rate of a single channel. In WDM systems the data rate per channel remains the same, only multiple channels carry data across the link. Dense wavelength division multiplexing (DWDM) promises even more wavelengths packed together in the same fibre. This multiplication of channels increases the bandwidth capacity rapidly. Networks are looking into making use of technology that will ensure no electronic signal regeneration at any point within the DWDM network. Examples are; reconfigurable optical add/drop multiplexers (ROADM) and optical cross connect (OXC) units. These components essentially enable network operators to split, combine and multiplex optical signals carried by optical fibre. WDM allows network operators to increase the capacity of existing networks without expensive re-cabling. This provides networks with the flexibility to be upgraded to larger bandwidths and for reconfiguration of network services. Further, WDM technology opens up an opportunity of marketing flexibility to network operators, where operators not only have the option to rent out cables and fibres but wavelengths as well. Cross phase modulation (XPM) poses a problem to WDM networks. The refractive index experienced by a neighbouring optical signal, not only depends on the signal’s intensity but on the intensity of the co-propagating signal as well. This effect leads to a phase change and is known as XPM. This work investigates the characteristics of XPM. It is shown that, in a two channel WDM network, a probe signal’s SOP can be steered by controlling a high intensity pump signal’s SOP. This effect could be applied to make a wavelength converter. Experimental results show that the degree of polarization (DOP) of a probe signal degrades according to a mathematical model found in literature. The pump and probe signals are shown to experience maximum interaction, for orthogonal probe-pump SOP vector orientations. This may be problematic to polarization mode dispersion compensators. Additionally, experimental results point out that the SOP of a probe signal is much more active in the presence of a high intensity pump, as compared to the single signal transmission scenario.
- Full Text:
- Date Issued: 2013
Characterisation and biotic classification of Eastern Cape mixed substrate shores
- Authors: Garner, Cornelia Johanna
- Date: 2013
- Subjects: Coastal sediments -- South Africa -- Eastern Cape , Coastal biodiversity --- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10641 , http://hdl.handle.net/10948/d1020825
- Description: A significant proportion of the South African coastline is composed of both soft (mostly sand) and hard (mostly bedrock) substrata, i.e. “mixed”. This study described and classified macrobenthic assemblages of 20 Eastern Cape mixed substrate shores that differed in shore topography and the extent and position of intertidal rock and sand. A stratified random approach was used. Species richness, composition, abundance and environmental variables were determined. Commonly used beach indices were calculated. A total of 78 macrofaunal and 172 macroalgal species from rock substrate assemblages and 205 macrofauna species from sediment were recorded. Total species richness and richness per substratum exceeded that of sandy beaches devoid of rock and rocky shores with no sand. Rhodophyta were the most diverse and abundant algae, dominating all low-elevation rock surfaces as midlittoral and infralittoral turfs. Chlorophyta diversity was higher than at rocky shores, contributing more to cover-abundance at study sites and in microhabitats with an increased sand load. Sessile macrofauna species richness and abundance was lower than that of rocky shores. Polychaetes and crustaceans were the most diverse and abundant beach infauna. Species richness of both substrates declined from the low shore towards the high shore, but abundance trends varied substantially. The presence and extent of an intertidal biotope/subzone at either substrate depended on substrate availability.The supralittoral fringe in both substrate types was most often affected. Zonal overlap was evident on rock substrate: assemblages of raised midlittoral rock surfaces were enriched by species from lower surfaces sometimes leading to elimination of character taxa. Classification and ordination identified three potential mixed substrate shore biotic types: Biotic type A (Jania-Corallina- Polysiphonia turf) was characterised by robustly-textured algal turfs, a lowered predominance and diversity of polychaetes and an increase in crustacean abundance and diversity in sediment. Biotic type B (Polysiphonia-Tayloriella-Caulacanthus turf) had intermediately and biotic type C (Arthrocardia-Laurencia turf) the most sheltered eulittoral zones and beaches. DCCA identified the major environmental parameters affecting the macrobiota as: the level of wave energy, geological control of waves by hard substrate, sediment grain size and sediment inundation. A strong cross-shore wave attenuation results in sheltered sediments and midshore rock surfaces. Beach macrofauna were highly variable and diverse, which directly opposes previous perceptions about the sediment-bound biota of mixed substrate shores. The hierarchical cluster analysis produced a biotic classification of mixed substrate shores that was indicative of a biotic response to the total effects of leading environmental parameters. Macrobenthos of rock surfaces and sediment therefore showed potential to be used as an alternative or complementary to physical characteristics in classifying mixed substrate shores.
- Full Text:
- Date Issued: 2013
- Authors: Garner, Cornelia Johanna
- Date: 2013
- Subjects: Coastal sediments -- South Africa -- Eastern Cape , Coastal biodiversity --- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10641 , http://hdl.handle.net/10948/d1020825
- Description: A significant proportion of the South African coastline is composed of both soft (mostly sand) and hard (mostly bedrock) substrata, i.e. “mixed”. This study described and classified macrobenthic assemblages of 20 Eastern Cape mixed substrate shores that differed in shore topography and the extent and position of intertidal rock and sand. A stratified random approach was used. Species richness, composition, abundance and environmental variables were determined. Commonly used beach indices were calculated. A total of 78 macrofaunal and 172 macroalgal species from rock substrate assemblages and 205 macrofauna species from sediment were recorded. Total species richness and richness per substratum exceeded that of sandy beaches devoid of rock and rocky shores with no sand. Rhodophyta were the most diverse and abundant algae, dominating all low-elevation rock surfaces as midlittoral and infralittoral turfs. Chlorophyta diversity was higher than at rocky shores, contributing more to cover-abundance at study sites and in microhabitats with an increased sand load. Sessile macrofauna species richness and abundance was lower than that of rocky shores. Polychaetes and crustaceans were the most diverse and abundant beach infauna. Species richness of both substrates declined from the low shore towards the high shore, but abundance trends varied substantially. The presence and extent of an intertidal biotope/subzone at either substrate depended on substrate availability.The supralittoral fringe in both substrate types was most often affected. Zonal overlap was evident on rock substrate: assemblages of raised midlittoral rock surfaces were enriched by species from lower surfaces sometimes leading to elimination of character taxa. Classification and ordination identified three potential mixed substrate shore biotic types: Biotic type A (Jania-Corallina- Polysiphonia turf) was characterised by robustly-textured algal turfs, a lowered predominance and diversity of polychaetes and an increase in crustacean abundance and diversity in sediment. Biotic type B (Polysiphonia-Tayloriella-Caulacanthus turf) had intermediately and biotic type C (Arthrocardia-Laurencia turf) the most sheltered eulittoral zones and beaches. DCCA identified the major environmental parameters affecting the macrobiota as: the level of wave energy, geological control of waves by hard substrate, sediment grain size and sediment inundation. A strong cross-shore wave attenuation results in sheltered sediments and midshore rock surfaces. Beach macrofauna were highly variable and diverse, which directly opposes previous perceptions about the sediment-bound biota of mixed substrate shores. The hierarchical cluster analysis produced a biotic classification of mixed substrate shores that was indicative of a biotic response to the total effects of leading environmental parameters. Macrobenthos of rock surfaces and sediment therefore showed potential to be used as an alternative or complementary to physical characteristics in classifying mixed substrate shores.
- Full Text:
- Date Issued: 2013
Clarifying the influence of human-environment interaction in nature-based adventure tourism in the Tsitsikamma, South Africa
- Authors: Giddy, Julia K
- Date: 2013
- Subjects: Human ecology -- South Africa -- Tsitsikammaberge , Tourism -- South Africa -- Tsitsikammaberge
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10674 , http://hdl.handle.net/10948/d1020782
- Description: Adventure tourism (AT), defined as “a broad spectrum of outdoor touristic activities,often commercialized and involving an interaction with the natural environment away from the participants’ home range and containing elements of risk,” (Hall, 1992, p. 143) is currently one of the fastest growing sub-sectors of the tourism industry (Buckley 2010). Because it has emerged relatively recently as a field of study, a number of scholars have called for ongoing research in the area, see Swarbrooke (2003), Pomfret (2006), Buckley (2010), Rogerson (2007), and Williams & Soutar (2005). Much of this research, to date, has focused on marketing, injury caused by AT participation, environmental impacts, and the broad notion of “risk” associated with AT. The problem is that little of this work has focused on the significance of the environment in adventure tourism – an important element inherent in its definition. Thus, this thesis aims to move beyond a general risk-based analysis of AT, and focus on the role of the environment. This is done through a human-environment interaction approach undertaken in Tsitsikamma Village where five adventure tourist operations are based. The first step in operationalizing this approach was to develop a conceptual framework that integrated adventure tourism into a general framework on humanenvironment interaction. The second step was to use a research instrument which enabled one to examine the influence of the environment on human motivations and adventure tourism experiences, and not only the influence of humans on the environment. The former was accomplished through questionnaires based on external, environmental elements that attract adventure tourists as well as inherent personality traits impel such tourists to participate in AT. The latter, based on interviews and participant perceptions, sought to establish the significance of impacts on the environment as well as initiatives taken by AT companies to minimize environmental damage. The findings show that although risk/thrill does play a role, AT motivations and experiences are complex and multidimensional. The environment does significantly influence both motivations and even more so AT experiences. Furthermore, there are distinct differences between the motivations and experiences of participants in different types of AT activities, indicating that generalizing the industry as whole neglects these significant differences. In terms of influences on the environment, the results show that most AT operators in the Tsitsikamma have some consideration for environmental protection and take some initiatives to minimize environmental damage, though the degree to which this occurs differs significantly. Furthermore, activity participants do not believe that the activities have a strong negative impact on the environment, though the majority acknowledge small impacts. The types of impacts observed by participants vary significantly between companies. This thesis demonstrates the manner in which the two-way relationship between humans and the environment manifests itself in the commercial AT industry. The result is a well-rounded examination of the influence of human-environment interaction on AT participants.
- Full Text:
- Date Issued: 2013
- Authors: Giddy, Julia K
- Date: 2013
- Subjects: Human ecology -- South Africa -- Tsitsikammaberge , Tourism -- South Africa -- Tsitsikammaberge
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10674 , http://hdl.handle.net/10948/d1020782
- Description: Adventure tourism (AT), defined as “a broad spectrum of outdoor touristic activities,often commercialized and involving an interaction with the natural environment away from the participants’ home range and containing elements of risk,” (Hall, 1992, p. 143) is currently one of the fastest growing sub-sectors of the tourism industry (Buckley 2010). Because it has emerged relatively recently as a field of study, a number of scholars have called for ongoing research in the area, see Swarbrooke (2003), Pomfret (2006), Buckley (2010), Rogerson (2007), and Williams & Soutar (2005). Much of this research, to date, has focused on marketing, injury caused by AT participation, environmental impacts, and the broad notion of “risk” associated with AT. The problem is that little of this work has focused on the significance of the environment in adventure tourism – an important element inherent in its definition. Thus, this thesis aims to move beyond a general risk-based analysis of AT, and focus on the role of the environment. This is done through a human-environment interaction approach undertaken in Tsitsikamma Village where five adventure tourist operations are based. The first step in operationalizing this approach was to develop a conceptual framework that integrated adventure tourism into a general framework on humanenvironment interaction. The second step was to use a research instrument which enabled one to examine the influence of the environment on human motivations and adventure tourism experiences, and not only the influence of humans on the environment. The former was accomplished through questionnaires based on external, environmental elements that attract adventure tourists as well as inherent personality traits impel such tourists to participate in AT. The latter, based on interviews and participant perceptions, sought to establish the significance of impacts on the environment as well as initiatives taken by AT companies to minimize environmental damage. The findings show that although risk/thrill does play a role, AT motivations and experiences are complex and multidimensional. The environment does significantly influence both motivations and even more so AT experiences. Furthermore, there are distinct differences between the motivations and experiences of participants in different types of AT activities, indicating that generalizing the industry as whole neglects these significant differences. In terms of influences on the environment, the results show that most AT operators in the Tsitsikamma have some consideration for environmental protection and take some initiatives to minimize environmental damage, though the degree to which this occurs differs significantly. Furthermore, activity participants do not believe that the activities have a strong negative impact on the environment, though the majority acknowledge small impacts. The types of impacts observed by participants vary significantly between companies. This thesis demonstrates the manner in which the two-way relationship between humans and the environment manifests itself in the commercial AT industry. The result is a well-rounded examination of the influence of human-environment interaction on AT participants.
- Full Text:
- Date Issued: 2013
Foraging ecology of Cape Gannets (Morus Capensis) at Bird Island, Algoa Bay
- Authors: Green, David Bruce
- Date: 2013
- Subjects: Birds of prey -- Behavior -- South Africa -- Algoa Bay , Gannets -- South Africa -- Algoa Bay , Birds -- Breeding -- South Africa -- Algoa Bay
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10725 , http://hdl.handle.net/10948/d1020790
- Description: The Cape gannet has undergone considerable population change and redistribution over the past 50 years. This has been linked to shifts in the abundance and distribution of their dominant prey, sardine and anchovy. Five breeding colonies, along the west coast of Southern Africa, have shown rapid population declines as a result of reduced prey availability. In contrast, a single colony (Bird Island, Algoa Bay) on the south coast of South Africa has, over the same period, grown fivefold and now supports approximately two thirds of the total population. Due to its conservation importance, and isolation from other breeding localities, it is important to assess the health of the Bird Island colony, and determine how foraging distribution relates to the environment to evaluate current measures of protection. This was achieved through two related studies; a long-term dietary analysis spanning 34 years, and a spatial foraging study, which related three years of tracking data to estimates of prey availability, oceanographic features and marine protected areas (MPAs). The results of the dietary study showed that the dietary constituents of Cape gannets breeding at Bird Island have remained similar over the last three decades, but the importance of sardine and anchovy has increased significantly. For sardine, in particular, this reflects an increased availability of this species (as deduced from hydroacoustic surveys) within the foraging range of the Bird Island colony. The dietary abundance of anchovy was found to be negatively correlated with that of sardine. Surprisingly,.the dietary abundance of anchovy was also negatively correlated with estimates of its availability based on acoustic surveys. The latter is likely to be due to sardine being a preferred prey item. Recent decreases in the dietary contribution of sardine (since 2005) suggest that this species is becoming less available to gannets, with profound implications in terms of nutrient gain associated with foraging. However, this has been mediated by an increase in the dietary contribution of anchovy, which now accounts for the vast majority of prey taken. Spatially, the foraging range of the Bird Island colony expanded during the three years of study, indicating an increase in effort. This increase was likely in an effort to track a distributional change of sardine and anchovy, which showed an apparent westward shift during the study period. There was, however, no evidence of birds tracking features associated with high productivity. This may have been partly due to anomalously warm conditions during the summer of 2012/2013, in which an absence of coastal upwelling prevented surface cooling. Nonetheless, low sea surface temperatures and high chlorophyll a concentrations do not seem to be reliable indicators of important Cape gannet foragingareas. Foraging effort was largely concentrated outside of MPAs, indicating that the current MPA network provides little protection for foraging gannets. This could change with the additional protection of the proposed Greater Addo Elephant National Park MPA expansion, as prey species are allowed to recover following the removal of fishing pressure. Overall, the colony appears to be in good condition as the diet is still dominated by live prey items, and the foraging range remains smaller than many of the colonies along the west coast. However, it is important that monitoring be continued, in particular with respect to changes in the availability of sardine and anchovy. Long-term shifts of these species out of the colony‘s foraging range could negatively influence the population in the future. This might be worsened by interspecific competition for prey resources. Considering the conservation importance of this population, maintenance of healthy prey stocks within the home range of breeding Cape gannets should be prioritised in order to prevent declines similar to those observed at west coast colonies.
- Full Text:
- Date Issued: 2013
- Authors: Green, David Bruce
- Date: 2013
- Subjects: Birds of prey -- Behavior -- South Africa -- Algoa Bay , Gannets -- South Africa -- Algoa Bay , Birds -- Breeding -- South Africa -- Algoa Bay
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10725 , http://hdl.handle.net/10948/d1020790
- Description: The Cape gannet has undergone considerable population change and redistribution over the past 50 years. This has been linked to shifts in the abundance and distribution of their dominant prey, sardine and anchovy. Five breeding colonies, along the west coast of Southern Africa, have shown rapid population declines as a result of reduced prey availability. In contrast, a single colony (Bird Island, Algoa Bay) on the south coast of South Africa has, over the same period, grown fivefold and now supports approximately two thirds of the total population. Due to its conservation importance, and isolation from other breeding localities, it is important to assess the health of the Bird Island colony, and determine how foraging distribution relates to the environment to evaluate current measures of protection. This was achieved through two related studies; a long-term dietary analysis spanning 34 years, and a spatial foraging study, which related three years of tracking data to estimates of prey availability, oceanographic features and marine protected areas (MPAs). The results of the dietary study showed that the dietary constituents of Cape gannets breeding at Bird Island have remained similar over the last three decades, but the importance of sardine and anchovy has increased significantly. For sardine, in particular, this reflects an increased availability of this species (as deduced from hydroacoustic surveys) within the foraging range of the Bird Island colony. The dietary abundance of anchovy was found to be negatively correlated with that of sardine. Surprisingly,.the dietary abundance of anchovy was also negatively correlated with estimates of its availability based on acoustic surveys. The latter is likely to be due to sardine being a preferred prey item. Recent decreases in the dietary contribution of sardine (since 2005) suggest that this species is becoming less available to gannets, with profound implications in terms of nutrient gain associated with foraging. However, this has been mediated by an increase in the dietary contribution of anchovy, which now accounts for the vast majority of prey taken. Spatially, the foraging range of the Bird Island colony expanded during the three years of study, indicating an increase in effort. This increase was likely in an effort to track a distributional change of sardine and anchovy, which showed an apparent westward shift during the study period. There was, however, no evidence of birds tracking features associated with high productivity. This may have been partly due to anomalously warm conditions during the summer of 2012/2013, in which an absence of coastal upwelling prevented surface cooling. Nonetheless, low sea surface temperatures and high chlorophyll a concentrations do not seem to be reliable indicators of important Cape gannet foragingareas. Foraging effort was largely concentrated outside of MPAs, indicating that the current MPA network provides little protection for foraging gannets. This could change with the additional protection of the proposed Greater Addo Elephant National Park MPA expansion, as prey species are allowed to recover following the removal of fishing pressure. Overall, the colony appears to be in good condition as the diet is still dominated by live prey items, and the foraging range remains smaller than many of the colonies along the west coast. However, it is important that monitoring be continued, in particular with respect to changes in the availability of sardine and anchovy. Long-term shifts of these species out of the colony‘s foraging range could negatively influence the population in the future. This might be worsened by interspecific competition for prey resources. Considering the conservation importance of this population, maintenance of healthy prey stocks within the home range of breeding Cape gannets should be prioritised in order to prevent declines similar to those observed at west coast colonies.
- Full Text:
- Date Issued: 2013
Rhenium (I), (III) and (V) complexes with potentially multidentate N, O-Donor ligands
- Authors: Habarurema, Gratien
- Date: 2013
- Subjects: Rhenium , Ligands
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10441 , http://hdl.handle.net/10948/d1020952
- Description: This study investigates the coordination modes of potential multidentate N,O-donor Schiff base ligands to the [ReVO]3+ and fac-[ReI(CO)3]+ cores. The project is aimed at the synthesis of tridentate, tetradentate and pentadentate Schiff bases ligands derived from the condensation reactions of benzaldehyde with different primary amines. The structures of these Schiff bases and their complexes were confirmed by using physical characterization methods, namely melting points, UV-Visible, UV-emission, 1H NMR and IR spectroscopy, X-ray diffractometry and elemental analysis. To further understand the coordination chemistry of rhenium, the prepared diiminediphenol N2O2-donor Schiff base ligand N N′-o-phenylene-bis(salicylaldimine) (H2salphen) was reacted with trans-[ReOCl3(PPh3)2] to yield cis-[ReCl2(ophsal)(PPh3)], whereas its reaction with trans-[ReOBr3(PPh3)2] resulted in the formation of the cis-[ReBr2(aphsal)(PPh3)].2CH3CN complex. In the above complexes the H2salphen ligand was cleaved leading to the coordinated tridentate ophsal NO2- and aphsal N2O-donor ligands. The reaction of H3aphsal with trans-[ReOBr3(PPh3)2] in toluene led to an unexpected compound, trans- [{[ReBr(aphsal)(PPh3)2]Br}{[ReBr(aphsal)(PPh3)2](ReO4)}] with an imido [ReNR]3+core. The ligand aphsal was coordinated tridentately with the doubly deprotonated amino nitrogen leading to Re(V)-imido complexes. The reaction of 2-((Z)-(2-aminoethylimino)methyl)phenol (H3amphol) with [Re(CO)5Cl] led to the rhenium(I) product fac-[Re(CO)3(H3amphol)] with H3amphol coordinated as a monoanionic tridentate chelate through its phenolate oxygen and amino nitrogen atoms. The X-ray crystal structures showed that all complexes display a distorted octahedral geometry around the central rhenium atom. The reaction of 2,6-bis(2-hydroxyphenylimino)pyridine (H2hpp) with cis-[ReO2I(PPh3)2] resulted in the reduced Re(III) product trans-[Re(hpp)(PPh3)2]I, while trans-[Re(hpp)(PPh3)2](ReO4) was isolated from its reaction with trans-[ReOCl3(PPh3)2]. The H2hpp ligand acts as a pentadentate N3O2-donor ligand where the two phenolic protons undergo deprotonation and its three nitrogens act as neutral donor atoms. Both compounds resulted from a disproportionation reaction characterized by the produced perrhenate counter-ion. The complex fac-[Re(CO)3(H2hpp)Cl] was prepared from [Re(CO)5Cl] and H2hpp in toluene. The H2hpp ligand acted as a neutral bidentate N,N-donor chelate. The metal is coordinated to three carbonyl donors in a facial orientation, two neutral nitrogen atoms and a chloride ligand. The reactions of the potentially tetradentate ligand N,N'-ethylenebis(salicylideneimine) (H2salen) with different rhenium(V) precursors resulted in the formation of two dimeric oxorhenium (V) compounds. In the reaction of H2salen with trans-[ReOCl3(PPh3)2] in ethanol, the highly unusual distorted dimeric complex (μ-salen)[ReOCl2(PPh3)]2 was isolated, in which salen2- is coordinated as a tetradentate to two oxorhenium(V) centres, and salen2- is present as a bidentate monoanionic ligand on each rhenium center. The reaction of cis- [ReO2I(PPh3)2] with H2salen led to the formation of the neutral dimeric oxorhenium(V) complex (μ-O)[ReO(salen)]2 in which the tetradentate chelate salen acts as a tetradentate dianionic ligand through its phenolate oxygens and nitrogen atoms of the azomethine groups. In its reaction with H2hmp the compound (μ-O)[ReO(hmp)]2 was isolated. In this product the pentadentate ligand H2hmp coordinated as tetradentate via its phenolic oxygen and nitrogen atoms. The reaction of the potentially tetradentate N1,N2-bis(aminobenzylidene)-1,2-ethylenediamine (H2amben) with trans-[ReOCl3(PPh3)2] led to the formation of the monocationic square-pyramidal complex salt [ReO(amben)](ReO4.
- Full Text:
- Date Issued: 2013
- Authors: Habarurema, Gratien
- Date: 2013
- Subjects: Rhenium , Ligands
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10441 , http://hdl.handle.net/10948/d1020952
- Description: This study investigates the coordination modes of potential multidentate N,O-donor Schiff base ligands to the [ReVO]3+ and fac-[ReI(CO)3]+ cores. The project is aimed at the synthesis of tridentate, tetradentate and pentadentate Schiff bases ligands derived from the condensation reactions of benzaldehyde with different primary amines. The structures of these Schiff bases and their complexes were confirmed by using physical characterization methods, namely melting points, UV-Visible, UV-emission, 1H NMR and IR spectroscopy, X-ray diffractometry and elemental analysis. To further understand the coordination chemistry of rhenium, the prepared diiminediphenol N2O2-donor Schiff base ligand N N′-o-phenylene-bis(salicylaldimine) (H2salphen) was reacted with trans-[ReOCl3(PPh3)2] to yield cis-[ReCl2(ophsal)(PPh3)], whereas its reaction with trans-[ReOBr3(PPh3)2] resulted in the formation of the cis-[ReBr2(aphsal)(PPh3)].2CH3CN complex. In the above complexes the H2salphen ligand was cleaved leading to the coordinated tridentate ophsal NO2- and aphsal N2O-donor ligands. The reaction of H3aphsal with trans-[ReOBr3(PPh3)2] in toluene led to an unexpected compound, trans- [{[ReBr(aphsal)(PPh3)2]Br}{[ReBr(aphsal)(PPh3)2](ReO4)}] with an imido [ReNR]3+core. The ligand aphsal was coordinated tridentately with the doubly deprotonated amino nitrogen leading to Re(V)-imido complexes. The reaction of 2-((Z)-(2-aminoethylimino)methyl)phenol (H3amphol) with [Re(CO)5Cl] led to the rhenium(I) product fac-[Re(CO)3(H3amphol)] with H3amphol coordinated as a monoanionic tridentate chelate through its phenolate oxygen and amino nitrogen atoms. The X-ray crystal structures showed that all complexes display a distorted octahedral geometry around the central rhenium atom. The reaction of 2,6-bis(2-hydroxyphenylimino)pyridine (H2hpp) with cis-[ReO2I(PPh3)2] resulted in the reduced Re(III) product trans-[Re(hpp)(PPh3)2]I, while trans-[Re(hpp)(PPh3)2](ReO4) was isolated from its reaction with trans-[ReOCl3(PPh3)2]. The H2hpp ligand acts as a pentadentate N3O2-donor ligand where the two phenolic protons undergo deprotonation and its three nitrogens act as neutral donor atoms. Both compounds resulted from a disproportionation reaction characterized by the produced perrhenate counter-ion. The complex fac-[Re(CO)3(H2hpp)Cl] was prepared from [Re(CO)5Cl] and H2hpp in toluene. The H2hpp ligand acted as a neutral bidentate N,N-donor chelate. The metal is coordinated to three carbonyl donors in a facial orientation, two neutral nitrogen atoms and a chloride ligand. The reactions of the potentially tetradentate ligand N,N'-ethylenebis(salicylideneimine) (H2salen) with different rhenium(V) precursors resulted in the formation of two dimeric oxorhenium (V) compounds. In the reaction of H2salen with trans-[ReOCl3(PPh3)2] in ethanol, the highly unusual distorted dimeric complex (μ-salen)[ReOCl2(PPh3)]2 was isolated, in which salen2- is coordinated as a tetradentate to two oxorhenium(V) centres, and salen2- is present as a bidentate monoanionic ligand on each rhenium center. The reaction of cis- [ReO2I(PPh3)2] with H2salen led to the formation of the neutral dimeric oxorhenium(V) complex (μ-O)[ReO(salen)]2 in which the tetradentate chelate salen acts as a tetradentate dianionic ligand through its phenolate oxygens and nitrogen atoms of the azomethine groups. In its reaction with H2hmp the compound (μ-O)[ReO(hmp)]2 was isolated. In this product the pentadentate ligand H2hmp coordinated as tetradentate via its phenolic oxygen and nitrogen atoms. The reaction of the potentially tetradentate N1,N2-bis(aminobenzylidene)-1,2-ethylenediamine (H2amben) with trans-[ReOCl3(PPh3)2] led to the formation of the monocationic square-pyramidal complex salt [ReO(amben)](ReO4.
- Full Text:
- Date Issued: 2013
On meshless methods : a novel interpolatory method and a GPU-accelerated implementation
- Authors: Hamed, Maien Mohamed Osman
- Date: 2013
- Subjects: Engineering mathematics , Numerical analysis
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10509 , http://hdl.handle.net/10948/d1018227
- Description: Meshless methods have been developed to avoid the numerical burden imposed by meshing in the Finite Element Method. Such methods are especially attrac- tive in problems that require repeated updates to the mesh, such as problems with discontinuities or large geometrical deformations. Although meshing is not required for solving problems with meshless methods, the use of meshless methods gives rise to different challenges. One of the main challenges associated with meshless methods is imposition of essential boundary conditions. If exact interpolants are used as shape functions in a meshless method, imposing essen- tial boundary conditions can be done in the same way as the Finite Element Method. Another attractive feature of meshless methods is that their use involves compu- tations that are largely independent from one another. This makes them suitable for implementation to run on highly parallel computing systems. Highly par- allel computing has become widely available with the introduction of software development tools that enable developing general-purpose programs that run on Graphics Processing Units. In the current work, the Moving Regularized Interpolation method has been de- veloped, which is a novel method of constructing meshless shape functions that achieve exact interpolation. The method is demonstrated in data interpolation and in partial differential equations. In addition, an implementation of the Element-Free Galerkin method has been written to run on a Graphics Processing Unit. The implementation is described and its performance is compared to that of a similar implementation that does not make use of the Graphics Processing Unit.
- Full Text:
- Date Issued: 2013
- Authors: Hamed, Maien Mohamed Osman
- Date: 2013
- Subjects: Engineering mathematics , Numerical analysis
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10509 , http://hdl.handle.net/10948/d1018227
- Description: Meshless methods have been developed to avoid the numerical burden imposed by meshing in the Finite Element Method. Such methods are especially attrac- tive in problems that require repeated updates to the mesh, such as problems with discontinuities or large geometrical deformations. Although meshing is not required for solving problems with meshless methods, the use of meshless methods gives rise to different challenges. One of the main challenges associated with meshless methods is imposition of essential boundary conditions. If exact interpolants are used as shape functions in a meshless method, imposing essen- tial boundary conditions can be done in the same way as the Finite Element Method. Another attractive feature of meshless methods is that their use involves compu- tations that are largely independent from one another. This makes them suitable for implementation to run on highly parallel computing systems. Highly par- allel computing has become widely available with the introduction of software development tools that enable developing general-purpose programs that run on Graphics Processing Units. In the current work, the Moving Regularized Interpolation method has been de- veloped, which is a novel method of constructing meshless shape functions that achieve exact interpolation. The method is demonstrated in data interpolation and in partial differential equations. In addition, an implementation of the Element-Free Galerkin method has been written to run on a Graphics Processing Unit. The implementation is described and its performance is compared to that of a similar implementation that does not make use of the Graphics Processing Unit.
- Full Text:
- Date Issued: 2013
Diet and foraging distribution of gentoo penguins pygoscelis papua at Cow Bay, Falkland Islands
- Authors: Handley, Jonathan Murray
- Date: 2013
- Subjects: Gentoo penguin -- Food -- Falkland Islands
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10724 , http://hdl.handle.net/10948/d1020377
- Description: Knowledge of diet and distribution in marine top predators is critical in interpreting their ecological role. Furthermore, this information is required for effective management and conservation of these species. For gentoo penguins at the Falkland Islands a previous overlap in dietary items with commercial fisheries was recognised. Despite this the at-sea distribution has been poorly studied and only at a few localities. Therefore, this thesis looks to broaden the knowledge of foraging ecology for gentoo penguins at another site in the archipelago, Cow Bay. The aim was firstly, through stomach content analysis, to determine if diet changed over a large temporal scale (2002/03/04 – 2011/12/13), and between the chick guard and crèche periods of chick rearing. Secondly, through GPS loggers, to assess distribution at sea during the incubation and chick guard periods (2012/13). Additionally, foraging ecology between genders was investigated. Gentoo penguins at Cow Bay foraged primarily on fish (66-99 percent) throughout the entire study period. The principle prey item by mass was Patagonotothen spp., considered previously as discard by fisheries but now an important commercial resource, for all periods (47-78 percent) except that of the 2012/13 crèche period (19 percent). During this period Sprattus fugensis made up the bulk of the diet (52 percent). Cephalopods, particularly Loligo gahi (1-24 percent), were also prominent in the diet and crustaceans contributed negligibly. The diet indicated that gentoo penguins are capable of both a benthic and pelagic feeding strategy which likely reflects changes in local prey abundance. Birds typically conducted foraging activities during daylight hours with greater trip duration, path length, maximum distance and area utilised during the incubation period than the guard. All trips were confined to the continental shelf and within the boundaries of a marine management zone, the Falkland Islands Interim Conservation Zone (FICZ). Males and females fed on the same size and composition of prey items. Trip duration, path length and maximum distance from the colony were not significantly different, although males foraged in a slightly larger area than females marginally to the north. As at-sea distribution was confined within the FICZ this management area provides protection to food resources of gentoo penguins breeding at Cow Bay. At this site, the population is increasing, likely associated with increased prey availability as evidenced by record catches of Patagonotothen spp. in recent years at the Falkland Islands. Continued long term monitoring of gentoo penguin diet and fishery yields to allow detection of possible competition in the future is recommended. As marine sentinels, on-going monitoring of gentoo penguin populations at the Falkland Islands is likely to provide early warning signs of reduced prey availability.
- Full Text:
- Date Issued: 2013
- Authors: Handley, Jonathan Murray
- Date: 2013
- Subjects: Gentoo penguin -- Food -- Falkland Islands
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10724 , http://hdl.handle.net/10948/d1020377
- Description: Knowledge of diet and distribution in marine top predators is critical in interpreting their ecological role. Furthermore, this information is required for effective management and conservation of these species. For gentoo penguins at the Falkland Islands a previous overlap in dietary items with commercial fisheries was recognised. Despite this the at-sea distribution has been poorly studied and only at a few localities. Therefore, this thesis looks to broaden the knowledge of foraging ecology for gentoo penguins at another site in the archipelago, Cow Bay. The aim was firstly, through stomach content analysis, to determine if diet changed over a large temporal scale (2002/03/04 – 2011/12/13), and between the chick guard and crèche periods of chick rearing. Secondly, through GPS loggers, to assess distribution at sea during the incubation and chick guard periods (2012/13). Additionally, foraging ecology between genders was investigated. Gentoo penguins at Cow Bay foraged primarily on fish (66-99 percent) throughout the entire study period. The principle prey item by mass was Patagonotothen spp., considered previously as discard by fisheries but now an important commercial resource, for all periods (47-78 percent) except that of the 2012/13 crèche period (19 percent). During this period Sprattus fugensis made up the bulk of the diet (52 percent). Cephalopods, particularly Loligo gahi (1-24 percent), were also prominent in the diet and crustaceans contributed negligibly. The diet indicated that gentoo penguins are capable of both a benthic and pelagic feeding strategy which likely reflects changes in local prey abundance. Birds typically conducted foraging activities during daylight hours with greater trip duration, path length, maximum distance and area utilised during the incubation period than the guard. All trips were confined to the continental shelf and within the boundaries of a marine management zone, the Falkland Islands Interim Conservation Zone (FICZ). Males and females fed on the same size and composition of prey items. Trip duration, path length and maximum distance from the colony were not significantly different, although males foraged in a slightly larger area than females marginally to the north. As at-sea distribution was confined within the FICZ this management area provides protection to food resources of gentoo penguins breeding at Cow Bay. At this site, the population is increasing, likely associated with increased prey availability as evidenced by record catches of Patagonotothen spp. in recent years at the Falkland Islands. Continued long term monitoring of gentoo penguin diet and fishery yields to allow detection of possible competition in the future is recommended. As marine sentinels, on-going monitoring of gentoo penguin populations at the Falkland Islands is likely to provide early warning signs of reduced prey availability.
- Full Text:
- Date Issued: 2013
A mathematical investigation of the effects of sexual orientation and HIV status on HPV transmission and vaccination
- Authors: Holtzhausen, Tresia Louisa
- Date: 2013
- Subjects: Virus diseases -- Mathematical models , Cervix uteri -- Cancer -- Treatment , Sexual orientation , Immune response -- Mathematical models
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/3946 , vital:20494
- Description: The effect of the inclusion of sexual behaviour, particularly three sexual orientation classes, on the transmission dynamics of HPV and cervical cancer incidence was investigated. A comprehensive literature review of mathematical models of HPV transmission and the natural history of cervical cancer was concluded. A mathematical model using ordinary differential equations was developed, which incorporated the three sexual orientation classes, and a sexual mixing algorithm for modelling the transmission dynamics. Reproduction numbers, determined through a simplified version of the developed model, indicated that the bisexual population could form a bridge between the heterosexual and homosexual population. The level of interaction is determined by the selection preferences of a bisexual individual to form a partnership with an individual of the same or opposite sex. The model was simulated, with parameters based on a South African population and HPV type 16/18, to investigate the effects of HIV status, sexual orientation and various vaccination strategies on HPV transmission and cervical cancer incidence. The results indicated that HIV status is a significant factor when determining cervical cancer incidence. The results regarding vaccination strategies agreed with results from the literature review with a two sex before sexual debut and catch up program the most effective, noting that with increased vaccination coverage of females the marginal impact on cervical cancer incidence of this approach diminished.
- Full Text:
- Date Issued: 2013
- Authors: Holtzhausen, Tresia Louisa
- Date: 2013
- Subjects: Virus diseases -- Mathematical models , Cervix uteri -- Cancer -- Treatment , Sexual orientation , Immune response -- Mathematical models
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/3946 , vital:20494
- Description: The effect of the inclusion of sexual behaviour, particularly three sexual orientation classes, on the transmission dynamics of HPV and cervical cancer incidence was investigated. A comprehensive literature review of mathematical models of HPV transmission and the natural history of cervical cancer was concluded. A mathematical model using ordinary differential equations was developed, which incorporated the three sexual orientation classes, and a sexual mixing algorithm for modelling the transmission dynamics. Reproduction numbers, determined through a simplified version of the developed model, indicated that the bisexual population could form a bridge between the heterosexual and homosexual population. The level of interaction is determined by the selection preferences of a bisexual individual to form a partnership with an individual of the same or opposite sex. The model was simulated, with parameters based on a South African population and HPV type 16/18, to investigate the effects of HIV status, sexual orientation and various vaccination strategies on HPV transmission and cervical cancer incidence. The results indicated that HIV status is a significant factor when determining cervical cancer incidence. The results regarding vaccination strategies agreed with results from the literature review with a two sex before sexual debut and catch up program the most effective, noting that with increased vaccination coverage of females the marginal impact on cervical cancer incidence of this approach diminished.
- Full Text:
- Date Issued: 2013