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The impact of total productive maintenance (TPM) on manufacturing performance at the Colt Section of DaimlerChrysler in the Eastern Cape
- Authors: Ncube, Mfowabo
- Date: 2006
- Subjects: Total productive maintenance , Plant maintenance -- Management , Automobile industry and trade -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8560 , http://hdl.handle.net/10948/579 , Total productive maintenance , Plant maintenance -- Management , Automobile industry and trade -- South Africa -- Eastern Cape
- Description: Today's successful manufacturing organisations require a significant competitive advantage, hence the need to implement and develop a Total Productive Maintenance (TPM) strategy. This research paper addresses the impact of TPM on manufacturing performance at the Colt production facility (DCSA). A literature survey was undertaken into the elements and benefits of TPM. Questionaires were also sent to all levels of people at the Colt production facility for their views on TPM and the impact, they believe, it has had on manufacturing performance. In conclusion, this research paper has also led to the development of recommendations to improve TPM activities at the Colt production facility. From the research, it was shown that top management support for TPM activities is needed and that training is an essential factor for TPM's success in improving manufacturing performance.
- Full Text:
- Authors: Ncube, Mfowabo
- Date: 2006
- Subjects: Total productive maintenance , Plant maintenance -- Management , Automobile industry and trade -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8560 , http://hdl.handle.net/10948/579 , Total productive maintenance , Plant maintenance -- Management , Automobile industry and trade -- South Africa -- Eastern Cape
- Description: Today's successful manufacturing organisations require a significant competitive advantage, hence the need to implement and develop a Total Productive Maintenance (TPM) strategy. This research paper addresses the impact of TPM on manufacturing performance at the Colt production facility (DCSA). A literature survey was undertaken into the elements and benefits of TPM. Questionaires were also sent to all levels of people at the Colt production facility for their views on TPM and the impact, they believe, it has had on manufacturing performance. In conclusion, this research paper has also led to the development of recommendations to improve TPM activities at the Colt production facility. From the research, it was shown that top management support for TPM activities is needed and that training is an essential factor for TPM's success in improving manufacturing performance.
- Full Text:
The constitutional rights of 'benefactor children' and 'saviour siblings' to bodily intergrity and autonomy
- Authors: Du Plessis, Emma Kate
- Date: 2011
- Subjects: Children's rights , Civil rights , Genetic engineering
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:10283 , http://hdl.handle.net/10948/d1010420 , Children's rights , Civil rights , Genetic engineering
- Description: In modern society, children are acknowledged as bearers of both children‟s rights and all other rights in the Bill of Rights which generally apply to children. One important right, outside of section 28, is that of bodily integrity or the right to control and decide what happens to their body. Therefore, children theoretically have the right to consent to medical treatment and surgery. However, children are generally deemed to lack the necessary maturity to make decisions of this nature and require parental consent before any medical procedure may be performed. Following the enactment of the Children‟s Act 38 of 2005, the age of consent for medical intervention was lowered to the uniform age of twelve. Children above the age of twelve are recognised as having the capacity to make their own decisions in respect of bodily integrity, whereas those under twelve still require parental consent. While this may be a positive evelopment, it is potentially problematic for two groups of children, known as „benefactor children‟ and „saviour siblings‟. In the last 50 years, there has been a noticeable advancement in the field of genetic research. One such development is the possibility of creating one child to save the life of another through tissue or organ donation. This has provided options to parents of children with life threatening conditions where before, there was little hope of a cure. Now, at the request of these parents, children can be specifically “genetically engineered” as an embryo, to become a tissue or organ match to a sick sibling. These children are known as „saviour siblings‟. Another group of children has emerged. While not the result of “genetic engineering”, they serve a similar purpose in being potential life-saving donors to an ill sibling and are known as „benefactor children‟. Both categories of children enjoy the protection of fundamental rights. For those who are under twelve years of age however, the right to bodily integrity can be infringed upon by the proposed surgical removal of organs or tissue for the benefit of a sick sibling, based purely on a parent‟s consent. At stake too, is the right to reproductive autonomy. Parents bear children for a number of different reasons, which can include raising a child to save the life of another. As they have the right to reproductive autonomy, adults are able to decide when they want children and for what reason they want children, which can include the various techniques used to bring about „saviour siblings‟. However, as rights are mutually interrelated and nterdependent, they cannot be viewed in isolation. Therefore, it must be asked: does a person‟s right to reproductive autonomy, as guaranteed by the Constitution, justify interference with an embryo? As an embryo is not recognised in South African law as a legal subject, it will be difficult to justify interference with this right on this basis. The right to consent to medical intervention only from age twelve was described as potentially problematic for „benefactor children‟ and „saviour siblings‟, as parents with seriously ill children may become so emotionally burdened, that they place the welfare of the sick child over that of the healthy child. Thus, it is possible that parents will consent to any and all procedures on the „benefactor child‟ or „saviour sibling‟, regardless of the implications to the health and suffering of the healthy child. Section 28(2) of the Constitution states that the child‟s best interests are of paramount importance but, it must be asked, whose best interests are more important when more than one child is involved? As this is a decision parents are incapable of making at that time, the decision should be made by a neutral, impartial and unemotional third party such as the Court, which can be assisted by the Family Advocate and an ombudsman, who are experts in assisting children and promoting their best interests. Presently, South African law does not expressly address „saviour siblings‟. However, with few changes to the National Health Act and other Regulations, this is an area which could be regulated in time. These changes could include finalising the draft regulations as well as providing a list of the medical and dental purposes for which blood and tissue can be removed and should make specific reference to the removal of tissue, blood or blood products to treat a sick sibling. It is also imperative that South Africa regulates these matters now, as „saviour siblings‟ are no longer simply a matter for the future. Furthermore, legislation needs to be amended and enacted to prevent the law from becoming out-dated and redundant, leaving „benefactor children‟ and „saviour siblings‟ vulnerable while law is being drafted. In that international law is silent on the matter, South Africa would be well advised to consider foreign law such as the United Kingdom, in developing its law. As the United Kingdom has developed a National Board, so too should South Africa, as this would assist in regulating „saviour siblings‟ by allowing members to review each proposed case of „saviour siblings‟. This is merely one recommendation of several which could facilitate a smooth, controlled regulation of a highly emotional topic. Children remain one of the most vulnerable groups in society and their rights are often susceptible to infringement or abuse. It is incumbent on the law to ensure that, wherever possible, these rights are protected, especially as science continues to advance and it becomes more difficult to determine what is morally correct.
- Full Text:
- Authors: Du Plessis, Emma Kate
- Date: 2011
- Subjects: Children's rights , Civil rights , Genetic engineering
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:10283 , http://hdl.handle.net/10948/d1010420 , Children's rights , Civil rights , Genetic engineering
- Description: In modern society, children are acknowledged as bearers of both children‟s rights and all other rights in the Bill of Rights which generally apply to children. One important right, outside of section 28, is that of bodily integrity or the right to control and decide what happens to their body. Therefore, children theoretically have the right to consent to medical treatment and surgery. However, children are generally deemed to lack the necessary maturity to make decisions of this nature and require parental consent before any medical procedure may be performed. Following the enactment of the Children‟s Act 38 of 2005, the age of consent for medical intervention was lowered to the uniform age of twelve. Children above the age of twelve are recognised as having the capacity to make their own decisions in respect of bodily integrity, whereas those under twelve still require parental consent. While this may be a positive evelopment, it is potentially problematic for two groups of children, known as „benefactor children‟ and „saviour siblings‟. In the last 50 years, there has been a noticeable advancement in the field of genetic research. One such development is the possibility of creating one child to save the life of another through tissue or organ donation. This has provided options to parents of children with life threatening conditions where before, there was little hope of a cure. Now, at the request of these parents, children can be specifically “genetically engineered” as an embryo, to become a tissue or organ match to a sick sibling. These children are known as „saviour siblings‟. Another group of children has emerged. While not the result of “genetic engineering”, they serve a similar purpose in being potential life-saving donors to an ill sibling and are known as „benefactor children‟. Both categories of children enjoy the protection of fundamental rights. For those who are under twelve years of age however, the right to bodily integrity can be infringed upon by the proposed surgical removal of organs or tissue for the benefit of a sick sibling, based purely on a parent‟s consent. At stake too, is the right to reproductive autonomy. Parents bear children for a number of different reasons, which can include raising a child to save the life of another. As they have the right to reproductive autonomy, adults are able to decide when they want children and for what reason they want children, which can include the various techniques used to bring about „saviour siblings‟. However, as rights are mutually interrelated and nterdependent, they cannot be viewed in isolation. Therefore, it must be asked: does a person‟s right to reproductive autonomy, as guaranteed by the Constitution, justify interference with an embryo? As an embryo is not recognised in South African law as a legal subject, it will be difficult to justify interference with this right on this basis. The right to consent to medical intervention only from age twelve was described as potentially problematic for „benefactor children‟ and „saviour siblings‟, as parents with seriously ill children may become so emotionally burdened, that they place the welfare of the sick child over that of the healthy child. Thus, it is possible that parents will consent to any and all procedures on the „benefactor child‟ or „saviour sibling‟, regardless of the implications to the health and suffering of the healthy child. Section 28(2) of the Constitution states that the child‟s best interests are of paramount importance but, it must be asked, whose best interests are more important when more than one child is involved? As this is a decision parents are incapable of making at that time, the decision should be made by a neutral, impartial and unemotional third party such as the Court, which can be assisted by the Family Advocate and an ombudsman, who are experts in assisting children and promoting their best interests. Presently, South African law does not expressly address „saviour siblings‟. However, with few changes to the National Health Act and other Regulations, this is an area which could be regulated in time. These changes could include finalising the draft regulations as well as providing a list of the medical and dental purposes for which blood and tissue can be removed and should make specific reference to the removal of tissue, blood or blood products to treat a sick sibling. It is also imperative that South Africa regulates these matters now, as „saviour siblings‟ are no longer simply a matter for the future. Furthermore, legislation needs to be amended and enacted to prevent the law from becoming out-dated and redundant, leaving „benefactor children‟ and „saviour siblings‟ vulnerable while law is being drafted. In that international law is silent on the matter, South Africa would be well advised to consider foreign law such as the United Kingdom, in developing its law. As the United Kingdom has developed a National Board, so too should South Africa, as this would assist in regulating „saviour siblings‟ by allowing members to review each proposed case of „saviour siblings‟. This is merely one recommendation of several which could facilitate a smooth, controlled regulation of a highly emotional topic. Children remain one of the most vulnerable groups in society and their rights are often susceptible to infringement or abuse. It is incumbent on the law to ensure that, wherever possible, these rights are protected, especially as science continues to advance and it becomes more difficult to determine what is morally correct.
- Full Text:
Evaluation of debt management policy implementation towards revenue management in government leased properties
- Mzekwa-Khiva, Nomonde Lindelani
- Authors: Mzekwa-Khiva, Nomonde Lindelani
- Date: 2013
- Subjects: Monetary policy , Debts, Public -- South Africa -- Eastern Cape , Financial crises -- South Africa -- Eastern Cape , Debts, Public
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8880 , http://hdl.handle.net/10948/d1020633
- Description: The study sought to evaluate debt management policy implementation towards revenue management in government leased properties of the Eastern Cape Provincial Treasury at the Transkei Development and Reserve Fund. Secondly, the study aimed at developing a tool for assisting policy-makers and officials involved in debt management and revenue collection. In order to address the research problem, a case study involving randomly selected 27 employees from the Eastern Cape Provincial Treasury and housing ward committee members was adopted. Self-administered questionnaires and interviews were the two data collection techniques utilised. All participants were involved in the study during tea and lunch breaks at the workplace; this constituted the employees’ natural environment. Both quantitative and qualitative designs were utilised in analysing data. Descriptive statistical analysis using excel was utilised to summarise the responses, analyse the demographic profiles of participants and their responses. The results were thus presented in the form of bar charts. Responses which could not be analysed using statistics were analysed qualitatively thus the advantages inherent in the two approaches were exploited. The evidence from the study suggests that government operational employees are aware of their roles and responsibilities as they relate to debt management and debt collection policy. The development of debt management policy promotes rental collection, improve property profitability and ensure the maintenance is in place to improve attractiveness of the government properties.
- Full Text:
- Authors: Mzekwa-Khiva, Nomonde Lindelani
- Date: 2013
- Subjects: Monetary policy , Debts, Public -- South Africa -- Eastern Cape , Financial crises -- South Africa -- Eastern Cape , Debts, Public
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8880 , http://hdl.handle.net/10948/d1020633
- Description: The study sought to evaluate debt management policy implementation towards revenue management in government leased properties of the Eastern Cape Provincial Treasury at the Transkei Development and Reserve Fund. Secondly, the study aimed at developing a tool for assisting policy-makers and officials involved in debt management and revenue collection. In order to address the research problem, a case study involving randomly selected 27 employees from the Eastern Cape Provincial Treasury and housing ward committee members was adopted. Self-administered questionnaires and interviews were the two data collection techniques utilised. All participants were involved in the study during tea and lunch breaks at the workplace; this constituted the employees’ natural environment. Both quantitative and qualitative designs were utilised in analysing data. Descriptive statistical analysis using excel was utilised to summarise the responses, analyse the demographic profiles of participants and their responses. The results were thus presented in the form of bar charts. Responses which could not be analysed using statistics were analysed qualitatively thus the advantages inherent in the two approaches were exploited. The evidence from the study suggests that government operational employees are aware of their roles and responsibilities as they relate to debt management and debt collection policy. The development of debt management policy promotes rental collection, improve property profitability and ensure the maintenance is in place to improve attractiveness of the government properties.
- Full Text:
The establishment of an African criminal court: strengths and weaknesses
- Authors: Philimon, Levina Kiiza
- Date: 2012
- Subjects: International criminal law -- Africa , Criminal courts -- Africa
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:10288 , http://hdl.handle.net/10948/d1019828
- Description: This treatise addresses the possible creation of an African criminal court for individual criminal responsibility for crime of genocide, crimes against humanity, and war crimes. It does so by critically analysing the Statutes of Special Court of Sierra Leone, International Criminal Tribunal for Rwanda, and Rome Statute of the International Criminal Court in relation to the provisions addressing the principle of individual criminal responsibility, jurisdiction, amnesty and immunity. Another aim is to indicate the strength and weaknesses of the cited statutes in relation to the above provisions. Finally a further aim is to provide an analysis of the statutes, and any other international law applicable and determine whether Africa needs a separate criminal court. The principle conclusion is that statutes are facing challenges in relations to the provisions above. It is established that Africa does not have a regional criminal court and the African Union has attempted to extend jurisdiction of the African Court of Justice and Human Rights to criminal jurisdiction but the process has amounted to heavy criticism and unforeseen legal implications. It is eventually concluded that Africa may consider the creation of a separate criminal court for the future and such a court is currently not needed. Support should be given to the ICC.
- Full Text:
- Authors: Philimon, Levina Kiiza
- Date: 2012
- Subjects: International criminal law -- Africa , Criminal courts -- Africa
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: vital:10288 , http://hdl.handle.net/10948/d1019828
- Description: This treatise addresses the possible creation of an African criminal court for individual criminal responsibility for crime of genocide, crimes against humanity, and war crimes. It does so by critically analysing the Statutes of Special Court of Sierra Leone, International Criminal Tribunal for Rwanda, and Rome Statute of the International Criminal Court in relation to the provisions addressing the principle of individual criminal responsibility, jurisdiction, amnesty and immunity. Another aim is to indicate the strength and weaknesses of the cited statutes in relation to the above provisions. Finally a further aim is to provide an analysis of the statutes, and any other international law applicable and determine whether Africa needs a separate criminal court. The principle conclusion is that statutes are facing challenges in relations to the provisions above. It is established that Africa does not have a regional criminal court and the African Union has attempted to extend jurisdiction of the African Court of Justice and Human Rights to criminal jurisdiction but the process has amounted to heavy criticism and unforeseen legal implications. It is eventually concluded that Africa may consider the creation of a separate criminal court for the future and such a court is currently not needed. Support should be given to the ICC.
- Full Text:
Investigating the potential of social media in instigating protest action: comparative study between Occupy Wall Street and Occupy JSE events
- Authors: Koen, Devon William
- Date: 2014
- Subjects: Social media -- Economic aspects -- South Africa -- Johannesburg , Social change -- South Africa -- Johannesburg , User-generated content -- South Africa -- Johannesburg
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:8438 , http://hdl.handle.net/10948/d1021071
- Description: In light of the cyber-activist simulated incidences dubbed Occupy Wall Street in New York City, New York, USA and the mirrored Occupy JSE movement in Johannesburg, South Africa, the internet and its social media networking sites have been instrumental in facilitating both the dissemination of information as well as facilitating a mediated environment for activists to coordinate online and offline protest action. This research examines the extent to which activists for social change have used social media sites such as Facebook, YouTube, web blogs and other online forums to garner support for their cause as well as generate social mobilization by creating awareness of the economic disparities in their respective societies. Established theories of social presence have been used to explain the relevance and role of social media tools in instigating social mobilization whether online or offline. This discussion focuses on the Occupation Movements staged in various countries globally and to what extent social media played in facilitating social change. It is important to note that the video footage and other social media data under analysis is specifically that which was uploaded onto YouTube and the subsequent URL links posted on Facebook. By scrutinizing these videos and calls for action as well as the comments posted by the international online community, this research elucidates the ‘trickling down effect’ of this type of cyber-activism on the behavioural patterns of contemporary South African society, and further argues that this process is indicative in the resultant Occupy JSE movement.
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- Authors: Koen, Devon William
- Date: 2014
- Subjects: Social media -- Economic aspects -- South Africa -- Johannesburg , Social change -- South Africa -- Johannesburg , User-generated content -- South Africa -- Johannesburg
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:8438 , http://hdl.handle.net/10948/d1021071
- Description: In light of the cyber-activist simulated incidences dubbed Occupy Wall Street in New York City, New York, USA and the mirrored Occupy JSE movement in Johannesburg, South Africa, the internet and its social media networking sites have been instrumental in facilitating both the dissemination of information as well as facilitating a mediated environment for activists to coordinate online and offline protest action. This research examines the extent to which activists for social change have used social media sites such as Facebook, YouTube, web blogs and other online forums to garner support for their cause as well as generate social mobilization by creating awareness of the economic disparities in their respective societies. Established theories of social presence have been used to explain the relevance and role of social media tools in instigating social mobilization whether online or offline. This discussion focuses on the Occupation Movements staged in various countries globally and to what extent social media played in facilitating social change. It is important to note that the video footage and other social media data under analysis is specifically that which was uploaded onto YouTube and the subsequent URL links posted on Facebook. By scrutinizing these videos and calls for action as well as the comments posted by the international online community, this research elucidates the ‘trickling down effect’ of this type of cyber-activism on the behavioural patterns of contemporary South African society, and further argues that this process is indicative in the resultant Occupy JSE movement.
- Full Text:
Brain-based learning and music education
- Authors: Viljoen, Jacobus Frederick
- Date: 2016
- Subjects: Music -- Instruction and study , Cognitive learning , Music teachers
- Language: English
- Type: Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10948/7359 , vital:21336
- Description: In the theoretical framework he highlights further implications of the Brain-based theory, which are (1) the importance of early development in children, (2) the importance of attention in class, (3) the inclusion of physical education in the learning process and (4) the value of an enriched learning environment. Furthermore, the researcher explores the types of stress found in the ordinary classroom as well as specific types of stress habitual to the music classroom, while also presenting possible solutions to these types of stress using the Brain-based learning theory. In chapter four, the researcher draws on the theoretical framework presented in the study to devise a Brain-based model for the music class. The study concludes with a summary of the literature and a brief concluding statement to music educators.
- Full Text:
- Authors: Viljoen, Jacobus Frederick
- Date: 2016
- Subjects: Music -- Instruction and study , Cognitive learning , Music teachers
- Language: English
- Type: Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10948/7359 , vital:21336
- Description: In the theoretical framework he highlights further implications of the Brain-based theory, which are (1) the importance of early development in children, (2) the importance of attention in class, (3) the inclusion of physical education in the learning process and (4) the value of an enriched learning environment. Furthermore, the researcher explores the types of stress found in the ordinary classroom as well as specific types of stress habitual to the music classroom, while also presenting possible solutions to these types of stress using the Brain-based learning theory. In chapter four, the researcher draws on the theoretical framework presented in the study to devise a Brain-based model for the music class. The study concludes with a summary of the literature and a brief concluding statement to music educators.
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An evaluation of the managerial practices of the Department of Education, Uitenhage district
- Authors: Jakavula, Nomvuyo Grace
- Date: 2006
- Subjects: South Africa. Dept. of Education -- Management , School management and organization -- South Africa -- Uitenhage
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8764 , http://hdl.handle.net/10948/525 , South Africa. Dept. of Education -- Management , School management and organization -- South Africa -- Uitenhage
- Description: In the changing South African climate the importance of the officials of the Department of Education cannot be ignored. The Department of Education has a mandate to change the lives of citizens by enriching the welfare of communities through education. The objective of this study was to evaluate the managerial practices of the Department of Education, the Uitenhage District in particular. In order to evaulate these managerial practices, an empirical research methodology was followed. A questionaire was utilized to obtain empirical data. The questionaire consisted of eighty statements using a Likert-type scale and responses to these statemenst are the basis of the results and recommendations made to conclude the study.
- Full Text: false
- Authors: Jakavula, Nomvuyo Grace
- Date: 2006
- Subjects: South Africa. Dept. of Education -- Management , School management and organization -- South Africa -- Uitenhage
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8764 , http://hdl.handle.net/10948/525 , South Africa. Dept. of Education -- Management , School management and organization -- South Africa -- Uitenhage
- Description: In the changing South African climate the importance of the officials of the Department of Education cannot be ignored. The Department of Education has a mandate to change the lives of citizens by enriching the welfare of communities through education. The objective of this study was to evaluate the managerial practices of the Department of Education, the Uitenhage District in particular. In order to evaulate these managerial practices, an empirical research methodology was followed. A questionaire was utilized to obtain empirical data. The questionaire consisted of eighty statements using a Likert-type scale and responses to these statemenst are the basis of the results and recommendations made to conclude the study.
- Full Text: false
The response of microalgal biomass and community composition to environmental factors in the Sundays Estuary
- Authors: Kotsedi, Daisy
- Date: 2011
- Subjects: Algal blooms -- South Africa -- Sundays River Estuary
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10609 , http://hdl.handle.net/10948/1434 , Algal blooms -- South Africa -- Sundays River Estuary
- Description: The Sundays Estuary is permanently open to the sea and has been described as channel-like along its entire length with a narrow intertidal area (mostly less than 5 - 6 m in width). The estuary experiences regular freshwater inflow with large supplies of nutrients, derived from the Orange River transfer scheme and agricultural return flow. In particular, nitrate concentrations are high as a result of fertilisers used in the Sundays River catchment area. The objectives of this study were to measure microalgal biomass and community composition and relate to flow, water quality and other environmental variables. Surveys in August 2006, March 2007, February, June and August 2008 showed that salinity less than 10 percent mostly occurred from 12.5 km from the mouth and this was also where the highest water column chlorophyll a (>20 μg l-1) was found. Different groups of microalgae formed phytoplankton blooms for the different sampling sessions, which were correlated with high chlorophyll a. These included blooms of green algae (August 2006), flagellates (March 2007), dinoflagellates (June 2008) and diatom species (February and August 2008). The dominant diatom (Cyclotella atomus) indicated nutrient-rich conditions. Green algae and diatoms were associated with low salinity water in the upper reaches of the estuary. Flagellates were dominant throughout the estuary particularly when nutrients were low, whereas the dinoflagellate bloom in June 2008 was correlated with high ammonium and pH. Maximum benthic chlorophyll a was found at 12.5 km from the mouth in February, June and August 2008 and was correlated with high sediment organic and moisture content. Benthic diatoms were associated with high temperature whereas some species in June 2008 were associated with high ammonium concentrations. The middle reaches of the estuary characterise a zone of deposition rather than suspension which would favour benthic diatom colonization. Phytoplankton cells settling out on the sediments may account for the high benthic chlorophyll a because maximum water column chlorophyll a was also found in the REI zone (where salinity is less than 10 percent and where high biological activity occurs) in the Sundays Estuary. The estuary was sampled over five consecutive weeks from March to April 2009 to identify environmental factors that support different microalgal bloom species. Phytoplankton blooms, defined as chlorophyll a greater than 20 μg l-1, were found during Weeks 1, 4 and 5 from the middle to the upper reaches of the estuary. Diatom species (Cylindrotheca closterium, Cyclotella atomus and Cyclostephanus dubius) occurred in bloom concentrations during these weeks. These diatom species are cosmopolitan and indicate brackish nutrient-rich water. Flagellates were the dominant group in Weeks 2 to 4, but positive correlations with chlorophyll a were found during Weeks 1 and 2. During the first week of this study the conditions were warm and calm (measured as temperature and wind speed) and there was a well developed bloom (38 μg l-1). There was a strong cold front from 17 to 19 March, which mixed the water column resulting in the decrease of the chlorophyll a levels (<20 μg l-1) and the bloom collapsed during Weeks 2 and 3. However, in Weeks 4 and 5 conditions were again calm and warmer, which appeared to stimulate the phytoplankton bloom. Nanoplankton (2.7 - 20 μm) was dominant during each week sampled and contributed a considerable amount (55 - 79 percent) to the phytoplankton biomass. Once again subtidal benthic chlorophyll a and water column chlorophyll a were highest 12.5 km from the mouth. Deposition of phytoplankton cells from the water column was evident in the benthic samples. The study showed that the Sundays Estuary is eutrophic and characterised by microalgal blooms consisting of different phytoplankton groups.
- Full Text:
- Authors: Kotsedi, Daisy
- Date: 2011
- Subjects: Algal blooms -- South Africa -- Sundays River Estuary
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10609 , http://hdl.handle.net/10948/1434 , Algal blooms -- South Africa -- Sundays River Estuary
- Description: The Sundays Estuary is permanently open to the sea and has been described as channel-like along its entire length with a narrow intertidal area (mostly less than 5 - 6 m in width). The estuary experiences regular freshwater inflow with large supplies of nutrients, derived from the Orange River transfer scheme and agricultural return flow. In particular, nitrate concentrations are high as a result of fertilisers used in the Sundays River catchment area. The objectives of this study were to measure microalgal biomass and community composition and relate to flow, water quality and other environmental variables. Surveys in August 2006, March 2007, February, June and August 2008 showed that salinity less than 10 percent mostly occurred from 12.5 km from the mouth and this was also where the highest water column chlorophyll a (>20 μg l-1) was found. Different groups of microalgae formed phytoplankton blooms for the different sampling sessions, which were correlated with high chlorophyll a. These included blooms of green algae (August 2006), flagellates (March 2007), dinoflagellates (June 2008) and diatom species (February and August 2008). The dominant diatom (Cyclotella atomus) indicated nutrient-rich conditions. Green algae and diatoms were associated with low salinity water in the upper reaches of the estuary. Flagellates were dominant throughout the estuary particularly when nutrients were low, whereas the dinoflagellate bloom in June 2008 was correlated with high ammonium and pH. Maximum benthic chlorophyll a was found at 12.5 km from the mouth in February, June and August 2008 and was correlated with high sediment organic and moisture content. Benthic diatoms were associated with high temperature whereas some species in June 2008 were associated with high ammonium concentrations. The middle reaches of the estuary characterise a zone of deposition rather than suspension which would favour benthic diatom colonization. Phytoplankton cells settling out on the sediments may account for the high benthic chlorophyll a because maximum water column chlorophyll a was also found in the REI zone (where salinity is less than 10 percent and where high biological activity occurs) in the Sundays Estuary. The estuary was sampled over five consecutive weeks from March to April 2009 to identify environmental factors that support different microalgal bloom species. Phytoplankton blooms, defined as chlorophyll a greater than 20 μg l-1, were found during Weeks 1, 4 and 5 from the middle to the upper reaches of the estuary. Diatom species (Cylindrotheca closterium, Cyclotella atomus and Cyclostephanus dubius) occurred in bloom concentrations during these weeks. These diatom species are cosmopolitan and indicate brackish nutrient-rich water. Flagellates were the dominant group in Weeks 2 to 4, but positive correlations with chlorophyll a were found during Weeks 1 and 2. During the first week of this study the conditions were warm and calm (measured as temperature and wind speed) and there was a well developed bloom (38 μg l-1). There was a strong cold front from 17 to 19 March, which mixed the water column resulting in the decrease of the chlorophyll a levels (<20 μg l-1) and the bloom collapsed during Weeks 2 and 3. However, in Weeks 4 and 5 conditions were again calm and warmer, which appeared to stimulate the phytoplankton bloom. Nanoplankton (2.7 - 20 μm) was dominant during each week sampled and contributed a considerable amount (55 - 79 percent) to the phytoplankton biomass. Once again subtidal benthic chlorophyll a and water column chlorophyll a were highest 12.5 km from the mouth. Deposition of phytoplankton cells from the water column was evident in the benthic samples. The study showed that the Sundays Estuary is eutrophic and characterised by microalgal blooms consisting of different phytoplankton groups.
- Full Text:
A study of the use of value based management (VBM) by multinational entities in the Eastern Cape motor industry cluster (ECMIC)
- Authors: Blouw, Mbuyiselo Edwin
- Date: 2005
- Subjects: Corporations -- Valuation , Automobile industry and trade -- South Africa
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8550 , http://hdl.handle.net/10948/421 , Corporations -- Valuation , Automobile industry and trade -- South Africa
- Description: Management’s response to shareholders’ return on investment as a priority occurs in an increasingly dynamic environment. Accompanying these activities is the need to realign responsibilities and to allocate scarce resources effectively. This is done in order to ensure that companies achieve global competitiveness and increase shareholders’ return on investment. Against this backdrop, local industry needs to find new methods or strategies in order to achieve world-class competitiveness, and to be able to access foreign investment. One way to achieve these goals is through Value Based Management (VBM). The objective of this study is to evaluate the strategic intent of Multinational Entities in applying VBM to increase shareholders’ return on investment. Based on the study, certain factors are critical to ensure the success of VBM. A postal survey to managers in the motor manufacturing and component manufacturing companies was conducted to check the managers’ familiarity with VBM, and their scope, and usage of VBM; and, based on the finding, to evaluate the impact of VBM on companies’ results. The empirical finding was compared with a literature review, and the following findings were made: There is a strong understanding and application of the VBM principle on the part of local entities with Foreign Direct Investment (FDI); Departmental performance is critical to an entity’s overall performance; Based on the study, 23 per cent of the respondents use Economic Value Added (EVA) as an internal reporting measure, and an average of 19 per cent use other metrics; A total of 89 per cent of respondents indicated that they strongly agree with the use of incentives for motivation. The above-mentioned points were covered by means of 4-M framework ― that is: Measurement, Management, Motivation, and Mindset.
- Full Text:
- Authors: Blouw, Mbuyiselo Edwin
- Date: 2005
- Subjects: Corporations -- Valuation , Automobile industry and trade -- South Africa
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8550 , http://hdl.handle.net/10948/421 , Corporations -- Valuation , Automobile industry and trade -- South Africa
- Description: Management’s response to shareholders’ return on investment as a priority occurs in an increasingly dynamic environment. Accompanying these activities is the need to realign responsibilities and to allocate scarce resources effectively. This is done in order to ensure that companies achieve global competitiveness and increase shareholders’ return on investment. Against this backdrop, local industry needs to find new methods or strategies in order to achieve world-class competitiveness, and to be able to access foreign investment. One way to achieve these goals is through Value Based Management (VBM). The objective of this study is to evaluate the strategic intent of Multinational Entities in applying VBM to increase shareholders’ return on investment. Based on the study, certain factors are critical to ensure the success of VBM. A postal survey to managers in the motor manufacturing and component manufacturing companies was conducted to check the managers’ familiarity with VBM, and their scope, and usage of VBM; and, based on the finding, to evaluate the impact of VBM on companies’ results. The empirical finding was compared with a literature review, and the following findings were made: There is a strong understanding and application of the VBM principle on the part of local entities with Foreign Direct Investment (FDI); Departmental performance is critical to an entity’s overall performance; Based on the study, 23 per cent of the respondents use Economic Value Added (EVA) as an internal reporting measure, and an average of 19 per cent use other metrics; A total of 89 per cent of respondents indicated that they strongly agree with the use of incentives for motivation. The above-mentioned points were covered by means of 4-M framework ― that is: Measurement, Management, Motivation, and Mindset.
- Full Text:
An investigation into visitors' satisfaction with Port Elizabeth's heritage museums
- Hou, Yue
- Authors: Hou, Yue
- Date: 2009
- Subjects: Art museum attendance -- South Africa -- Port Elizabeth , Customer satisfaction -- South Africa -- Port Elizabeth , Heritage tourism -- South Africa -- Port Elizabeth , Museums -- South Africa -- Port Elizabeth , Tourism -- South Africa -- Port Elizabeth
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:9361 , http://hdl.handle.net/10948/1250 , Art museum attendance -- South Africa -- Port Elizabeth , Customer satisfaction -- South Africa -- Port Elizabeth , Heritage tourism -- South Africa -- Port Elizabeth , Museums -- South Africa -- Port Elizabeth , Tourism -- South Africa -- Port Elizabeth
- Description: Cultural and heritage tourism, one of the fastest growing segments of the tourism industry, is becoming a major pillar in the tourism strategy of many countries. Like elsewhere in the world, museums play a significant role in heritage tourism. South Africa has a rich history of intangible cultural heritage which manifests itself in oral history, traditional music and dance, social practices and indigenous knowledge systems. It is becoming more important for museum managers to identify the variables that will enhance the attraction and retention of museum visitors. The aim of the study was to determine tourists’ satisfaction with their visit to Port Elizabeth’s heritage museums by comparing their expectations and experiences. This could help museum marketers to better understand their customers, and design experiences that match their expectations. The literature review presented a brief overview of heritage tourism, the museum experience, and visitors’ satisfaction. Concepts of heritage tourism, functions of museums and the different museum attributes that might impact customer satisfaction were discussed. Literature on visitors’ satisfaction included descriptions of the expectations and approaches to measuring customer satisfaction. A museum satisfaction conceptual model resulted from these reviews. ii The proposed model was modified in the empirical study. The data were collected by means of a survey, using self-administered questionnaires distributed to visitors at three heritage museums in Port Elizabeth. Two hundred and twelve useable questionnaires were received. The empirical findings did not fully support the conceptual model. By conducting a factor analysis, the data was reduced to eight factors, namely, human interaction, physical evidence, facilities, facility quality, exhibition, edutainment, escape and aestheticism. It was found that the satisfaction mean scores were consistently higher than the expectation mean scores. This implies that museum visitors were satisfied with their experience of the three heritage museums in Port Elizabeth. Finally, the results of the paired sample t-test and regression analyses tested and explained formulated hypotheses. The principal recommendations emanating from this study are summarised in two groups, namely: • recommendations pertaining to the strategic implications of the findings in terms of service, facilities and experience. For example, the museum administration could establish more facilities for the disabled and the elderly, consider discounting and promotion programmes, and increase the use of technology in their displays. • recommendations for future research. For example, future studies could be applied to investigate visitors’ satisfaction with other heritage museums in South Africa.
- Full Text:
- Authors: Hou, Yue
- Date: 2009
- Subjects: Art museum attendance -- South Africa -- Port Elizabeth , Customer satisfaction -- South Africa -- Port Elizabeth , Heritage tourism -- South Africa -- Port Elizabeth , Museums -- South Africa -- Port Elizabeth , Tourism -- South Africa -- Port Elizabeth
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: vital:9361 , http://hdl.handle.net/10948/1250 , Art museum attendance -- South Africa -- Port Elizabeth , Customer satisfaction -- South Africa -- Port Elizabeth , Heritage tourism -- South Africa -- Port Elizabeth , Museums -- South Africa -- Port Elizabeth , Tourism -- South Africa -- Port Elizabeth
- Description: Cultural and heritage tourism, one of the fastest growing segments of the tourism industry, is becoming a major pillar in the tourism strategy of many countries. Like elsewhere in the world, museums play a significant role in heritage tourism. South Africa has a rich history of intangible cultural heritage which manifests itself in oral history, traditional music and dance, social practices and indigenous knowledge systems. It is becoming more important for museum managers to identify the variables that will enhance the attraction and retention of museum visitors. The aim of the study was to determine tourists’ satisfaction with their visit to Port Elizabeth’s heritage museums by comparing their expectations and experiences. This could help museum marketers to better understand their customers, and design experiences that match their expectations. The literature review presented a brief overview of heritage tourism, the museum experience, and visitors’ satisfaction. Concepts of heritage tourism, functions of museums and the different museum attributes that might impact customer satisfaction were discussed. Literature on visitors’ satisfaction included descriptions of the expectations and approaches to measuring customer satisfaction. A museum satisfaction conceptual model resulted from these reviews. ii The proposed model was modified in the empirical study. The data were collected by means of a survey, using self-administered questionnaires distributed to visitors at three heritage museums in Port Elizabeth. Two hundred and twelve useable questionnaires were received. The empirical findings did not fully support the conceptual model. By conducting a factor analysis, the data was reduced to eight factors, namely, human interaction, physical evidence, facilities, facility quality, exhibition, edutainment, escape and aestheticism. It was found that the satisfaction mean scores were consistently higher than the expectation mean scores. This implies that museum visitors were satisfied with their experience of the three heritage museums in Port Elizabeth. Finally, the results of the paired sample t-test and regression analyses tested and explained formulated hypotheses. The principal recommendations emanating from this study are summarised in two groups, namely: • recommendations pertaining to the strategic implications of the findings in terms of service, facilities and experience. For example, the museum administration could establish more facilities for the disabled and the elderly, consider discounting and promotion programmes, and increase the use of technology in their displays. • recommendations for future research. For example, future studies could be applied to investigate visitors’ satisfaction with other heritage museums in South Africa.
- Full Text:
Uptake of liposomes into bacterial cells
- Authors: Oidu, Benjamin
- Date: 2013
- Subjects: Liposomes , Drug carriers (Pharmacy)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10165 , http://hdl.handle.net/10948/d1021010
- Description: Liposomes are small phospholipid vesicles that have been widely investigated as drug carriers for the delivery of therapeutic agents. A variety of liposome formulations are presently under clinical trial exploration, while others have already been approved for clinical use. The aim of this study was to optimize liposome uptake into bacterial cells. Both gram-positive and gram-negative bacteria were used in the study as well as Candida albicans.Response surface methodology (RSM) using a central composite design (CCD) model was used to optimize liposomal formulations of carboxyfluorescien (CF) for each of the three microbes, and also the three microbes in combination namely; Staphylococcus aureus (Sa), Escherichia coli (Ec) and Candida albicans (Ca). Percentage of CF encapsulated and CF increase in Uptake were investigated with respect to two independent variables that were, cholesterol (CHOL) and stearylamine (SA) content. Design Expert 8 was used for the purpose of finding the combination of independent variables that would yield an optimal formulation for each microbe and the three microbes in combination. The model selected by the software managed to reasonably correlate the predicted models to the experimental data. Encapsulation of carboxyfluorescien (CF) into a liposome formulation enhanced its uptake by Staphylococcus aureus and Escherichia coli as well as Candida albicans. This was evident in the increase in CF uptake when the uptake rate of free CF was compared with that of liposomal CF.
- Full Text:
- Authors: Oidu, Benjamin
- Date: 2013
- Subjects: Liposomes , Drug carriers (Pharmacy)
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10165 , http://hdl.handle.net/10948/d1021010
- Description: Liposomes are small phospholipid vesicles that have been widely investigated as drug carriers for the delivery of therapeutic agents. A variety of liposome formulations are presently under clinical trial exploration, while others have already been approved for clinical use. The aim of this study was to optimize liposome uptake into bacterial cells. Both gram-positive and gram-negative bacteria were used in the study as well as Candida albicans.Response surface methodology (RSM) using a central composite design (CCD) model was used to optimize liposomal formulations of carboxyfluorescien (CF) for each of the three microbes, and also the three microbes in combination namely; Staphylococcus aureus (Sa), Escherichia coli (Ec) and Candida albicans (Ca). Percentage of CF encapsulated and CF increase in Uptake were investigated with respect to two independent variables that were, cholesterol (CHOL) and stearylamine (SA) content. Design Expert 8 was used for the purpose of finding the combination of independent variables that would yield an optimal formulation for each microbe and the three microbes in combination. The model selected by the software managed to reasonably correlate the predicted models to the experimental data. Encapsulation of carboxyfluorescien (CF) into a liposome formulation enhanced its uptake by Staphylococcus aureus and Escherichia coli as well as Candida albicans. This was evident in the increase in CF uptake when the uptake rate of free CF was compared with that of liposomal CF.
- Full Text:
Influence of distance from the target on total response time, repeated punch force and anaerobic fatigue of amatuer boxers
- Authors: Trella, Christopher Andrew
- Date: 2012
- Subjects: Boxers (Sports) , Physical education and training
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:10111 , http://hdl.handle.net/10948/d1020942
- Description: The aim of this study was to determine the influence of distance from the target during dominant and non-dominant jab punches, on total response time, repeated jab punch force and anaerobic fatigue of amateur boxers. Data was gathered of the following variables: Biographical data, anthropometric data, total response time, change in total response time, number of punches, peak punch force and peak punch force fatigue resistance index. An exploratory and descriptive research design was used. Twelve male amateur boxers participated in this study. The participants were all either provincially or nationally ranked, between the ages 16 and 22 and in the competitive phase of their training. The data was compared to find statistical significance and it was found from the Wilcoxon ranked sign test that distance does not affect total response time, change in total response time, number of punches and peak punch force fatigue resistance index. However, it was found that distance affects peak punch force. Additionally,it was found using a Spearman rank correlation test that older boxers proved to have statistically significant faster total response times, the boxers that had slower total reponse times proved to have statistically significant less powerful peak punch force, the boxers that had slower total response times proved to have statistically significant larger fatigue resistance index, boxers with larger change in total response time proved to have statistically significant more powerful peak punch force and the boxers with larger peak punch force proved to have statistically significant smaller fatigue resistance index. The data presented provides an introduction of the exploration of how distance from a target relates to a boxer’s performance.
- Full Text:
- Authors: Trella, Christopher Andrew
- Date: 2012
- Subjects: Boxers (Sports) , Physical education and training
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:10111 , http://hdl.handle.net/10948/d1020942
- Description: The aim of this study was to determine the influence of distance from the target during dominant and non-dominant jab punches, on total response time, repeated jab punch force and anaerobic fatigue of amateur boxers. Data was gathered of the following variables: Biographical data, anthropometric data, total response time, change in total response time, number of punches, peak punch force and peak punch force fatigue resistance index. An exploratory and descriptive research design was used. Twelve male amateur boxers participated in this study. The participants were all either provincially or nationally ranked, between the ages 16 and 22 and in the competitive phase of their training. The data was compared to find statistical significance and it was found from the Wilcoxon ranked sign test that distance does not affect total response time, change in total response time, number of punches and peak punch force fatigue resistance index. However, it was found that distance affects peak punch force. Additionally,it was found using a Spearman rank correlation test that older boxers proved to have statistically significant faster total response times, the boxers that had slower total reponse times proved to have statistically significant less powerful peak punch force, the boxers that had slower total response times proved to have statistically significant larger fatigue resistance index, boxers with larger change in total response time proved to have statistically significant more powerful peak punch force and the boxers with larger peak punch force proved to have statistically significant smaller fatigue resistance index. The data presented provides an introduction of the exploration of how distance from a target relates to a boxer’s performance.
- Full Text:
An investigation of the challenges facing the ward committee system with specific reference to selected municipalities in the province of the Eastern Cape
- Authors: Ntlemeza, Albert Mncedisi
- Date: 2007
- Subjects: Local government -- South Africa -- Eastern Cape , Municipal government -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:8162 , http://hdl.handle.net/10948/584 , Local government -- South Africa -- Eastern Cape , Municipal government -- South Africa -- Eastern Cape
- Description: Local government in South Africa has undergone radical changes since the first democratic local government elections were held in 1995 and 1996. It is generally known that local government in South Africa was based on racial fragmentation. The new South Africa therefore has to go beyond purely representative democracy to address the inequalities of the apartheid era. The Constitution of the Republic of South Africa Act, 1996 (Act 108 of 1996), envisages a complete transformation of the local government system. Subsequently, a policy framework has been developed to give effect to a new vision of local government. The White Paper on Local Government was passed in March 1998. It spells out the framework and programme in terms of which the existing local government system will be radically transformed. This culminated in the birth of the concept of developmental local government. Developmental local government establishes the basis of a system of local government which is centrally concerned with working with local citizens and ward communities in particular to find sustainable ways to meet their needs and improve the quality of their lives. Developmental local government encourages public participation at the local level. One of the most powerful instruments by which the communities and groups become involved in local government affairs is through the ward committee structures and ward planning forums. The Municipal Systems Act, 2000 (Act 32 of 2000), makes provision for community participation. Ward committees are established in terms of section 17 (1) of the Municipal Structures Act, 1998 (Act 117 of 1998). Ward committees play an important role in creating a democratic culture of local participation and accountability. They are the main mechanisms available to municipalities and communities to enhance public participation in ix the local sphere of government. Their major obstacle is that their powers are limited to advising the communities and the relevant council. The White Paper on Local Government provides for three approaches which can assist municipalities to be more developmental, namely integrated development planning and budgeting, performance management and working together with local citizens. Ward committees provide a link between the council and these processes. The new system of local government also provides for the consideration of gender issues at the ward committee level. The local government policy framework requires that at least fifty percent of representation on ward committees should be women. The involvement of youth is also greatly encouraged. The system also provides for and clarifies the role/relationship with traditional leaders at the ward committee level. The local government legislative framework accepts and acknowledges the existence of traditional leaders. Their involvement in ward community activities and functions is well documented. Lastly, the capacity building of ward committees is posing a major challenge. In order for ward committee members to perform their functions effectively training must be provided. The respective local councils should be responsible for providing the necessary training to ward committees through the office of the speaker under which they fall. In the national sphere efforts are made to ensure that training for ward committees is provided.
- Full Text:
- Authors: Ntlemeza, Albert Mncedisi
- Date: 2007
- Subjects: Local government -- South Africa -- Eastern Cape , Municipal government -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:8162 , http://hdl.handle.net/10948/584 , Local government -- South Africa -- Eastern Cape , Municipal government -- South Africa -- Eastern Cape
- Description: Local government in South Africa has undergone radical changes since the first democratic local government elections were held in 1995 and 1996. It is generally known that local government in South Africa was based on racial fragmentation. The new South Africa therefore has to go beyond purely representative democracy to address the inequalities of the apartheid era. The Constitution of the Republic of South Africa Act, 1996 (Act 108 of 1996), envisages a complete transformation of the local government system. Subsequently, a policy framework has been developed to give effect to a new vision of local government. The White Paper on Local Government was passed in March 1998. It spells out the framework and programme in terms of which the existing local government system will be radically transformed. This culminated in the birth of the concept of developmental local government. Developmental local government establishes the basis of a system of local government which is centrally concerned with working with local citizens and ward communities in particular to find sustainable ways to meet their needs and improve the quality of their lives. Developmental local government encourages public participation at the local level. One of the most powerful instruments by which the communities and groups become involved in local government affairs is through the ward committee structures and ward planning forums. The Municipal Systems Act, 2000 (Act 32 of 2000), makes provision for community participation. Ward committees are established in terms of section 17 (1) of the Municipal Structures Act, 1998 (Act 117 of 1998). Ward committees play an important role in creating a democratic culture of local participation and accountability. They are the main mechanisms available to municipalities and communities to enhance public participation in ix the local sphere of government. Their major obstacle is that their powers are limited to advising the communities and the relevant council. The White Paper on Local Government provides for three approaches which can assist municipalities to be more developmental, namely integrated development planning and budgeting, performance management and working together with local citizens. Ward committees provide a link between the council and these processes. The new system of local government also provides for the consideration of gender issues at the ward committee level. The local government policy framework requires that at least fifty percent of representation on ward committees should be women. The involvement of youth is also greatly encouraged. The system also provides for and clarifies the role/relationship with traditional leaders at the ward committee level. The local government legislative framework accepts and acknowledges the existence of traditional leaders. Their involvement in ward community activities and functions is well documented. Lastly, the capacity building of ward committees is posing a major challenge. In order for ward committee members to perform their functions effectively training must be provided. The respective local councils should be responsible for providing the necessary training to ward committees through the office of the speaker under which they fall. In the national sphere efforts are made to ensure that training for ward committees is provided.
- Full Text:
Strategies for sustainable housing co-operatives in South Africa
- Authors: Jimoh, Richard Ajayi
- Date: 2012
- Subjects: Housing, Cooperative -- South Africa , Housing -- South Africa , Sustainable development -- South Africa , Housing -- Finance-- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:9690 , http://hdl.handle.net/10948/d1009500 , Housing, Cooperative -- South Africa , Housing -- South Africa , Sustainable development -- South Africa , Housing -- Finance-- South Africa
- Description: An increasing number of people are in need of housing that would improve long-term tenure for them. Private ownership is a well-known incentive for peoples’ participation in housing programmes. The current difficulties in obtaining credit for housing, following the global economic crisis, show that private individual home-ownership is not effective enough in addressing the housing needs of the low and middle income groups. As a result of this, the need to find an option that will solve the housing needs of the people became intense. However, the implementation of the co-operative housing delivery option in South Africa has not been successfully implemented as a result of the actions or the inactions of the role players. The study sought answer to the causes of the inability to successfully implement the co-operative housing approach through the use of ‘triad model’ that has to do with the ideology of co-operatives, the praxis and the organisational structures of the various housing co-operatives. The study was domiciled in a pragmatic paradigm, using the mixed methods research approach by conducting a three-stage research whereby convergent parallel design was adopted as the methodology. Questionnaires were administered to the chairpersons of the housing co-operatives identified in this stage one of the study. Stage two consisted of conducting interviews with chairpersons of six housing co-operatives using the purposive non-probability sampling method. The final stage was the survey among the members of the housing co-operatives interviewed. It was discovered, inter alia, that the membership of housing co-operatives was not voluntary; policy and legislative documents on social housing were biased against the co-operative housing approach; limited understanding of the co-operative approach exists among officials of government responsible for the implementations and a lack of training to members of the housing co-operatives by agencies of government responsible for propagating the approach was evident. Based on the findings, framework for sustainable housing co-operatives in South Africa was proposed from the strategies identified. The strategies identified were classified into the following factors: Policy and legislation; support services; education, training and information; and governance.
- Full Text:
- Authors: Jimoh, Richard Ajayi
- Date: 2012
- Subjects: Housing, Cooperative -- South Africa , Housing -- South Africa , Sustainable development -- South Africa , Housing -- Finance-- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:9690 , http://hdl.handle.net/10948/d1009500 , Housing, Cooperative -- South Africa , Housing -- South Africa , Sustainable development -- South Africa , Housing -- Finance-- South Africa
- Description: An increasing number of people are in need of housing that would improve long-term tenure for them. Private ownership is a well-known incentive for peoples’ participation in housing programmes. The current difficulties in obtaining credit for housing, following the global economic crisis, show that private individual home-ownership is not effective enough in addressing the housing needs of the low and middle income groups. As a result of this, the need to find an option that will solve the housing needs of the people became intense. However, the implementation of the co-operative housing delivery option in South Africa has not been successfully implemented as a result of the actions or the inactions of the role players. The study sought answer to the causes of the inability to successfully implement the co-operative housing approach through the use of ‘triad model’ that has to do with the ideology of co-operatives, the praxis and the organisational structures of the various housing co-operatives. The study was domiciled in a pragmatic paradigm, using the mixed methods research approach by conducting a three-stage research whereby convergent parallel design was adopted as the methodology. Questionnaires were administered to the chairpersons of the housing co-operatives identified in this stage one of the study. Stage two consisted of conducting interviews with chairpersons of six housing co-operatives using the purposive non-probability sampling method. The final stage was the survey among the members of the housing co-operatives interviewed. It was discovered, inter alia, that the membership of housing co-operatives was not voluntary; policy and legislative documents on social housing were biased against the co-operative housing approach; limited understanding of the co-operative approach exists among officials of government responsible for the implementations and a lack of training to members of the housing co-operatives by agencies of government responsible for propagating the approach was evident. Based on the findings, framework for sustainable housing co-operatives in South Africa was proposed from the strategies identified. The strategies identified were classified into the following factors: Policy and legislation; support services; education, training and information; and governance.
- Full Text:
Mediation practice : perceptions of practitioners from the African insider mediators platform
- Authors: Smith, Richard
- Date: 2013
- Subjects: Mediation , Mediators (Persons) , Social conflict
- Language: English
- Type: Thesis , Masters , MPhil
- Identifier: vital:8353 , http://hdl.handle.net/10948/d1020909
- Description: In African countries emerging from periods of violent crisis a layer of civil society practitioners and peacebuilders appear to play a critical role in mediating the inevitable disputes and tensions that arise. This treatise focuses on a sample of these mediating practitioners who perceive themselves in a variety of different ways, as peacebuilders, as conflict managers, as conflict resolution practitioners and as conflict transformation practitioners. The practitioners who participated in this study work at multiple levels to support the mediative processes that are needed in contexts of crisis and transition. They form part of a wider group of practitioners who have taken the initiative to organise insider mediators into a learning community of practitioners, under the auspices of the African Insider Mediators Platform (AIMP). This platform provides scholars with a useful research opportunity. The overall aim of this study is to explore the relationship between conflict transformation theory and the establishment of the AIMP as perceived by AIMP practitioners. It captures the perceptions that mediators have of the nature of the conflicts in which they are engaged and the influence of theoretical approaches on their practice. The treatise focuses on the perceptions of selected mediation practitioners associated with the AIMP. It draws out the conceptual lenses that are used to inform perceptions of effective mediation practice and that connect the perceptions of practitioners with the concepts contained within the conflict transformation theory. In so doing it describes the perceptions of practitioners and discusses the extent to which these perceptions resonate or deviate from theoretical conceptualisations of conflict in Africa and the theoretical frameworks that outline what constitutes an effective mediative response to this conflict. The insights into effectiveness that emerge from this approach are outlined in the treatise, drawing from background research that has informed the formation of the AIMP as well as from interviews carried out with selected mediation practitioners. The research findings suggest that there are several perceived connections between the theoretical underpinnings of conflict transformation approaches and the practice of the insider mediators involved in this study. The discussion of the data puts forward the proposition that the conceptual perceptions of the insider mediators involved in the study, in their description of elements of mediation practice and the nature of conflict, resonate strongly with the theories associated with conflict transformation thinking. In addition several additional theoretical influences appear to have been incorporated into an overall approach to discrete and collaborative mediation efforts that reinforce a strong connection between conflict transformation thinking and the practice of insider mediators. These relational connections between theory and practice are outlined in some detail in the description of the study that follows.
- Full Text:
- Authors: Smith, Richard
- Date: 2013
- Subjects: Mediation , Mediators (Persons) , Social conflict
- Language: English
- Type: Thesis , Masters , MPhil
- Identifier: vital:8353 , http://hdl.handle.net/10948/d1020909
- Description: In African countries emerging from periods of violent crisis a layer of civil society practitioners and peacebuilders appear to play a critical role in mediating the inevitable disputes and tensions that arise. This treatise focuses on a sample of these mediating practitioners who perceive themselves in a variety of different ways, as peacebuilders, as conflict managers, as conflict resolution practitioners and as conflict transformation practitioners. The practitioners who participated in this study work at multiple levels to support the mediative processes that are needed in contexts of crisis and transition. They form part of a wider group of practitioners who have taken the initiative to organise insider mediators into a learning community of practitioners, under the auspices of the African Insider Mediators Platform (AIMP). This platform provides scholars with a useful research opportunity. The overall aim of this study is to explore the relationship between conflict transformation theory and the establishment of the AIMP as perceived by AIMP practitioners. It captures the perceptions that mediators have of the nature of the conflicts in which they are engaged and the influence of theoretical approaches on their practice. The treatise focuses on the perceptions of selected mediation practitioners associated with the AIMP. It draws out the conceptual lenses that are used to inform perceptions of effective mediation practice and that connect the perceptions of practitioners with the concepts contained within the conflict transformation theory. In so doing it describes the perceptions of practitioners and discusses the extent to which these perceptions resonate or deviate from theoretical conceptualisations of conflict in Africa and the theoretical frameworks that outline what constitutes an effective mediative response to this conflict. The insights into effectiveness that emerge from this approach are outlined in the treatise, drawing from background research that has informed the formation of the AIMP as well as from interviews carried out with selected mediation practitioners. The research findings suggest that there are several perceived connections between the theoretical underpinnings of conflict transformation approaches and the practice of the insider mediators involved in this study. The discussion of the data puts forward the proposition that the conceptual perceptions of the insider mediators involved in the study, in their description of elements of mediation practice and the nature of conflict, resonate strongly with the theories associated with conflict transformation thinking. In addition several additional theoretical influences appear to have been incorporated into an overall approach to discrete and collaborative mediation efforts that reinforce a strong connection between conflict transformation thinking and the practice of insider mediators. These relational connections between theory and practice are outlined in some detail in the description of the study that follows.
- Full Text:
An investigation into the introduction of process analytical technology, using near infrared analysis, to selected pharmaceutical processes
- Authors: Naicker, Krishnaveni
- Date: 2007
- Subjects: Near infrared spectroscopy , Pharmaceutical chemistry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10153 , http://hdl.handle.net/10948/577 , http://hdl.handle.net/10948/d1011710 , Near infrared spectroscopy , Pharmaceutical chemistry
- Description: Introduction: Process analytical technologies are systems for the analysis and control of manufacturing processes to assure acceptable end-product quality. This is achieved by timely measurements of critical parameters and performance attributes of raw material and in-process material and processes. The introduction of process analytical technology using near infrared analysis was investigated in three areas, namely incoming raw material analysis, blend uniformity analysis and moisture determination in the fluid bed dryer. Methodology: Incoming raw material identification - The FOSS XDS rapid content analyzer was used for the development of a NIR method for the identification and material qualification of starch maize and lactose monohydrate. Blend uniformity analysis – The SP15 Laboratory Blender fitted with near infrared probe was utilized for the study. Two types of blend experiments were designed to monitor the distribution of magnesium stearate (lubricant) in the blend, namely, a powder blend utilizing lactose monohydrate and a granule blend utilizing Ridaq® granule. Software methods were developed to monitor the standard deviation of the absorbance at the wavelengths that were specific for lactose monohydrate, Ridaq® granule and magnesium stearate. To confirm the prediction of end-point using near infrared, results were verified using an atomic absorption method for magnesium stearate. The blends were sampled at the selected time intervals corresponding to three states of the blend, namely, before end-point, at end-point and after end-point using a sampling plan. An additional six blends were conducted for the granule blend and sampled when the standard deviation had reached a value below 3 x 10-6 at the magnesium stearate wavelength at four consecutive data points (standard deviation value extrapolated from blends carried out to predetermined time intervals). Moisture determination in the fluid bed dryer – Moisture values for two products (Product A and Product B) were retrospectively collected from past production batches. A process capability study was conducted on the moisture values to determine if the current process was in a state of control. Results and Discussion: Incoming raw material identification – The algorithms used for the spectral library were able to distinguish between the raw materials selected. The spectral library positively identified the starch maize and lactose monohydrate samples that were not present in the library. The negative challenge with pregelatinised starch and tablettose demonstrated that the spectral library was able to differentiate between closely related compounds. Blend uniformity analysis – Blends sampled at the predetermined time intervals demonstrated a homogeneous state when the standard deviation of the absorbance was low and a non-homogeneous state when the standard deviation of the absorbance was high, thus near infrared prediction on the state of the blend was confirmed by the standard analytical methods. The series of Ridaq® granule and magnesium stearate blends sampled when the standard deviation was below 3 x 10-6 were homogeneous with the exception of one blend that was marginally out of specification. Blend durations were significantly lower than the standard blend durations used in the facility and ranged from 112 to 198 seconds. Moisture determination in the fluid bed dryer – From the process capability study of the two products it was noted that Product A is stable but can still be optimized while Product B is at a desirable state. The statistical evaluation of the moisture values for Product A and Product B demonstrated that the use of the product temperature to monitor the moisture gave consistent results. The current process is stable and capable of producing repeatable results although near infrared provides a means for continuously monitoring the product moisture and allows one to take action to prevent over-drying or under-drying. Conclusion: From the investigations conducted, it can be seen that there is definitely a niche for process analytical technology at this pharmaceutical company. The implementation is a gradual process of change, which may take time, probably several years (Heinze & Hansen 2005).
- Full Text:
- Authors: Naicker, Krishnaveni
- Date: 2007
- Subjects: Near infrared spectroscopy , Pharmaceutical chemistry
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:10153 , http://hdl.handle.net/10948/577 , http://hdl.handle.net/10948/d1011710 , Near infrared spectroscopy , Pharmaceutical chemistry
- Description: Introduction: Process analytical technologies are systems for the analysis and control of manufacturing processes to assure acceptable end-product quality. This is achieved by timely measurements of critical parameters and performance attributes of raw material and in-process material and processes. The introduction of process analytical technology using near infrared analysis was investigated in three areas, namely incoming raw material analysis, blend uniformity analysis and moisture determination in the fluid bed dryer. Methodology: Incoming raw material identification - The FOSS XDS rapid content analyzer was used for the development of a NIR method for the identification and material qualification of starch maize and lactose monohydrate. Blend uniformity analysis – The SP15 Laboratory Blender fitted with near infrared probe was utilized for the study. Two types of blend experiments were designed to monitor the distribution of magnesium stearate (lubricant) in the blend, namely, a powder blend utilizing lactose monohydrate and a granule blend utilizing Ridaq® granule. Software methods were developed to monitor the standard deviation of the absorbance at the wavelengths that were specific for lactose monohydrate, Ridaq® granule and magnesium stearate. To confirm the prediction of end-point using near infrared, results were verified using an atomic absorption method for magnesium stearate. The blends were sampled at the selected time intervals corresponding to three states of the blend, namely, before end-point, at end-point and after end-point using a sampling plan. An additional six blends were conducted for the granule blend and sampled when the standard deviation had reached a value below 3 x 10-6 at the magnesium stearate wavelength at four consecutive data points (standard deviation value extrapolated from blends carried out to predetermined time intervals). Moisture determination in the fluid bed dryer – Moisture values for two products (Product A and Product B) were retrospectively collected from past production batches. A process capability study was conducted on the moisture values to determine if the current process was in a state of control. Results and Discussion: Incoming raw material identification – The algorithms used for the spectral library were able to distinguish between the raw materials selected. The spectral library positively identified the starch maize and lactose monohydrate samples that were not present in the library. The negative challenge with pregelatinised starch and tablettose demonstrated that the spectral library was able to differentiate between closely related compounds. Blend uniformity analysis – Blends sampled at the predetermined time intervals demonstrated a homogeneous state when the standard deviation of the absorbance was low and a non-homogeneous state when the standard deviation of the absorbance was high, thus near infrared prediction on the state of the blend was confirmed by the standard analytical methods. The series of Ridaq® granule and magnesium stearate blends sampled when the standard deviation was below 3 x 10-6 were homogeneous with the exception of one blend that was marginally out of specification. Blend durations were significantly lower than the standard blend durations used in the facility and ranged from 112 to 198 seconds. Moisture determination in the fluid bed dryer – From the process capability study of the two products it was noted that Product A is stable but can still be optimized while Product B is at a desirable state. The statistical evaluation of the moisture values for Product A and Product B demonstrated that the use of the product temperature to monitor the moisture gave consistent results. The current process is stable and capable of producing repeatable results although near infrared provides a means for continuously monitoring the product moisture and allows one to take action to prevent over-drying or under-drying. Conclusion: From the investigations conducted, it can be seen that there is definitely a niche for process analytical technology at this pharmaceutical company. The implementation is a gradual process of change, which may take time, probably several years (Heinze & Hansen 2005).
- Full Text:
Benzoyl isothiocyanates derived ligands as potential HIV-1 protease inhibitors and their reactions with gold ions
- Authors: Odame, Felix
- Date: 2016
- Subjects: HIV (Viruses) -- Enzymes , Enzyme inhibitors -- Research , Pharmaceutical chemistry , Biochemistry
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: http://hdl.handle.net/10948/33228 , vital:32585
- Description: The synthesis and evaluation of benzoyl isothiocyanate derivatives as potential HIV-1 protease inhibitors is presented. The ligands were first designed to fit the protease active site using Autodock 4.2. The design was based on the deNOVO method of drug design in which the active site coordinates from the crystal structure of protease bound to ritonavir was used. An attempt to access the scaffolds designed initially led to the formation of 2,2,4-trimethyl 2,3-dihydro-1H-1,5-benzodiazepin-5-ium isophthalate and 2-2-(3-methylphenyl-1Hbenzimidazole which could not be converted to the desired intermediate. A further attempt led to formation of amino acid and amino acid ester derivatives of benzoyl isothiocyanates which have been fully characterized and the reasons why the desired intermediates were not readily accessible explained. Scaffolds based on the benzoyl isothiocyanate derivatives of structurally diverse diamines were then screened. Sixty compounds have been synthesized and fully characterized using elemental analysis, spectroscopy, GC-MS and twenty-six crystal structures have been discussed. The DFT transition state studies of 11-phenyl- 1,8,10,12-tetraazatricyclo[7.4.0.02,7]trideca-2(7),3,5,9,11-pentaene-13-thione (20), N-(1Hbenzimidazol-2-yl)benzamide (21), 3-(1,3-benzothiazol-2-yl)-1-(benzoyl)thiourea (23), and N-[(9E)-8,10,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene] benzamide (39), have been carried out and their detailed density functional theory reaction mechanism have be computed. The Bernly algorithm was used in the determination of saddle points (transtions states), and the intrinsic reaction coordinates leading to the determination of intermediates were traced and optimized to a global minimum or in some cases a local minimum was obtained. The cell viability tests of diamine derivatives which was done by exposing white blood cells to the compounds (inhibitors) at 37 °C and a pH of 7.4 showed that 1-(4-bromobenzoyl)-3-[2- ({[(4-bromophenyl)formamido]methanethioyl}amino)phenyl]thiourea (46), 1-(3-chloro benzoyl)-3-[2-({[(3-chlorophenyl)formamido]methanethioyl}amino)phenyl]thiourea (48), 1- (3-bromobenzoyl)-3-[2-({[(3-bromophenyl)formamido]methanethioyl}amino)phenyl] thiourea (49) and 3-benzoyl-1-(4-{[(phenylformamido)methanethioyl]amino}butyl)thiourea (54), in that group of compounds were cytotoxic with EC50 values of 17.04 ± 9.75 μM, 69.20± 38.16 μM, 35.90 ± 20.55 μM and 68.37 ± 26.45 μM, respectively. 4-Bromo-N-[(9E)-8,10,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene] benzamide (32), 4-methoxy-N-[(9E)-8,10,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene]benzamide (33) and 3-chloro-N-[(9E)-8,10,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene] benzamide (37) were also cytotoxic giving EC50 values of 45.47 ± 21.92, 45.09 ±13.79 and 74.94 ± 13.17 μM, respectively. 3-(1,3-Benzothiazol-2-yl)-1-(3-bromobenzoyl)thiourea (31) and 3-(1,3-benzothiazoyl-2-yl)-1-(4-nitrobenzoyl)thiourea (30) derivatives were also found to be cytotoxic with EC50 values of 1.207 ± 0.58 and 24.08 ±13.14 nM, respectively. 11-(4-Chlorophenyl-1,8,10, 12-tetraazatricyclo[7.4.0.02,7]trideca-2(7),3,5,9,11-pentaene-13-thione (12), 11-(4-methoxyphenyl)-1,8,10,12-tetraazatricyclo[7.4.0.02,7]trideca-2(7),3,9,1-pentaene-13-thione (14), and 11-phenyl-1,8,10,12-tetraazatricyclo[7.4.0.02,7]trideca-2(7),3,5,9,11-pentaene-13-thione (20), were found to be cytotoxic giving EC50 values of 0.152 ± 0.051, 37.96 ± 21.87 and 5.28 ± 2.95 μM, respectively. In the enzyme inhibition studies compound 49 gave a percentage inhibition of 97.03 ± 10.61% at 100 μM, but the fact that it is cytoxic might make it less useful, whilst compounds 19 and 16 had a percentage inhibition of 59.57 ± 13.59% (4-nitro derivative) and 79.97 ± 11.97% (3-nitro derivative) respectively at 100 μM of inhibitor and 20 μM of enzyme (HIV-1 protease). The results suggests that the presence of the nitro group at position 3 (16) and 4 (19) leads to an increase in activity against HIV-1 protease.
- Full Text:
- Authors: Odame, Felix
- Date: 2016
- Subjects: HIV (Viruses) -- Enzymes , Enzyme inhibitors -- Research , Pharmaceutical chemistry , Biochemistry
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: http://hdl.handle.net/10948/33228 , vital:32585
- Description: The synthesis and evaluation of benzoyl isothiocyanate derivatives as potential HIV-1 protease inhibitors is presented. The ligands were first designed to fit the protease active site using Autodock 4.2. The design was based on the deNOVO method of drug design in which the active site coordinates from the crystal structure of protease bound to ritonavir was used. An attempt to access the scaffolds designed initially led to the formation of 2,2,4-trimethyl 2,3-dihydro-1H-1,5-benzodiazepin-5-ium isophthalate and 2-2-(3-methylphenyl-1Hbenzimidazole which could not be converted to the desired intermediate. A further attempt led to formation of amino acid and amino acid ester derivatives of benzoyl isothiocyanates which have been fully characterized and the reasons why the desired intermediates were not readily accessible explained. Scaffolds based on the benzoyl isothiocyanate derivatives of structurally diverse diamines were then screened. Sixty compounds have been synthesized and fully characterized using elemental analysis, spectroscopy, GC-MS and twenty-six crystal structures have been discussed. The DFT transition state studies of 11-phenyl- 1,8,10,12-tetraazatricyclo[7.4.0.02,7]trideca-2(7),3,5,9,11-pentaene-13-thione (20), N-(1Hbenzimidazol-2-yl)benzamide (21), 3-(1,3-benzothiazol-2-yl)-1-(benzoyl)thiourea (23), and N-[(9E)-8,10,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene] benzamide (39), have been carried out and their detailed density functional theory reaction mechanism have be computed. The Bernly algorithm was used in the determination of saddle points (transtions states), and the intrinsic reaction coordinates leading to the determination of intermediates were traced and optimized to a global minimum or in some cases a local minimum was obtained. The cell viability tests of diamine derivatives which was done by exposing white blood cells to the compounds (inhibitors) at 37 °C and a pH of 7.4 showed that 1-(4-bromobenzoyl)-3-[2- ({[(4-bromophenyl)formamido]methanethioyl}amino)phenyl]thiourea (46), 1-(3-chloro benzoyl)-3-[2-({[(3-chlorophenyl)formamido]methanethioyl}amino)phenyl]thiourea (48), 1- (3-bromobenzoyl)-3-[2-({[(3-bromophenyl)formamido]methanethioyl}amino)phenyl] thiourea (49) and 3-benzoyl-1-(4-{[(phenylformamido)methanethioyl]amino}butyl)thiourea (54), in that group of compounds were cytotoxic with EC50 values of 17.04 ± 9.75 μM, 69.20± 38.16 μM, 35.90 ± 20.55 μM and 68.37 ± 26.45 μM, respectively. 4-Bromo-N-[(9E)-8,10,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene] benzamide (32), 4-methoxy-N-[(9E)-8,10,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene]benzamide (33) and 3-chloro-N-[(9E)-8,10,17-triazatetracyclo[8.7.0.02,7.011,16]heptadeca-1(17),2,4,6,11(16),12,14-heptaen-9-ylidene] benzamide (37) were also cytotoxic giving EC50 values of 45.47 ± 21.92, 45.09 ±13.79 and 74.94 ± 13.17 μM, respectively. 3-(1,3-Benzothiazol-2-yl)-1-(3-bromobenzoyl)thiourea (31) and 3-(1,3-benzothiazoyl-2-yl)-1-(4-nitrobenzoyl)thiourea (30) derivatives were also found to be cytotoxic with EC50 values of 1.207 ± 0.58 and 24.08 ±13.14 nM, respectively. 11-(4-Chlorophenyl-1,8,10, 12-tetraazatricyclo[7.4.0.02,7]trideca-2(7),3,5,9,11-pentaene-13-thione (12), 11-(4-methoxyphenyl)-1,8,10,12-tetraazatricyclo[7.4.0.02,7]trideca-2(7),3,9,1-pentaene-13-thione (14), and 11-phenyl-1,8,10,12-tetraazatricyclo[7.4.0.02,7]trideca-2(7),3,5,9,11-pentaene-13-thione (20), were found to be cytotoxic giving EC50 values of 0.152 ± 0.051, 37.96 ± 21.87 and 5.28 ± 2.95 μM, respectively. In the enzyme inhibition studies compound 49 gave a percentage inhibition of 97.03 ± 10.61% at 100 μM, but the fact that it is cytoxic might make it less useful, whilst compounds 19 and 16 had a percentage inhibition of 59.57 ± 13.59% (4-nitro derivative) and 79.97 ± 11.97% (3-nitro derivative) respectively at 100 μM of inhibitor and 20 μM of enzyme (HIV-1 protease). The results suggests that the presence of the nitro group at position 3 (16) and 4 (19) leads to an increase in activity against HIV-1 protease.
- Full Text:
Uphononongo nzulu lokusetyenziswa kweenkumbulo nokulibala ngabalinganiswa kwiincwadi ezikhethiweyo zesiXhosa
- Authors: Notshe, Lwandlekazi
- Date: 2017
- Subjects: Xhosa literature , Xhosa drama -- Criticism and interpretation
- Language: English
- Type: Thesis , Doctoral , MBA
- Identifier: http://hdl.handle.net/10948/20087 , vital:29105
- Description: Olu phando luza kuphendla ukusetyenziswa kweenkumbulo nokulibala ngabalinganiswa kwiincwadi ezichongiweyo zesiXhosa. Apha kuvezwa ukuba iinkumbulo zinika umkhombandlela womakwenziwe. Kuza kugocwagocwa ezi ncwadi zilandelayo: Ingalo ngokubhalwe ngu-K.S. Bongela Elundini loThukela ngokubhalwe ngu-J.J.R. Jolobe Ukuqhawuka kwembeleko ngokubhalwe ngu-D.M. Jongilanga Ingqumbo yeminyanya ngokubhalwe ngu-A.C. Jordan Bhota Nonceba ibhalwe ngu-B.B. Mafuya UMakhwekhwetha ngokubhalwe ngu-R.F. Mcimeli Umqol’ uphandle ngokubhalwe ngu-M.A.P. Ngani Umkhonto kaTshiwo ngokubhalwe ngu-M.A.P. Ngani Unyana womntu ngokubhalwe ngu- N.Saule Vuleka mhlaba ngokubhalwe nguN. Saule Imijelo yegazi ngokubhalwe ngu-Z.S. Zotwana Apha kwezi ncwadi kuza kuhlutywa ukuba ukukhumbula nokulibala luyasetyenziswa ngabantu abantetho isisiXhosa nokuba wonke umntu unazo iinkumbulo, ingaba ziinkumbulo ezimnandi okanye ezinxunguphalisayo. Isahluko sokuqala salo msebenzi siza kunika amagqabantshintshi ngolu phando. Esi sahluko siqulathe: - Ingabula-zigcawu - Iinjongo zophando - Imibuzo ekhokelele ekwenziweni kolu phando - Indlela yokwenza olu phando - Ukubaluleka kolu phando - Okuthethwa zezinye iingcali ngeenkumbulo nokulibala - Ingcaciso magama Isahluko sesibini siqulathe iingcingane yeenkumbulo, ingcingane yobume bengqondo kwakunye nengcingane yokuqonda. Kukwajongwe abasunguli bezi ngcingane nemisebenzi yabo. Isahluko sesithathu siqwalasele iinkumbulo nempembelelo yazo kwinkcubeko nasentlalweni kwiincwadi ezichongiweyo. Isahluko sesine sijonge iinkumbulo zembali yepolitiki eMzantsi Afrika. Isahluko sesihlanu sicubungula iinkumbulo nokulibala kwezomthetho. Isahluko sesithandathu nesisesokugqibela - sishwankathela iziphumo zophando kukwanikwa nezindululo.
- Full Text:
- Authors: Notshe, Lwandlekazi
- Date: 2017
- Subjects: Xhosa literature , Xhosa drama -- Criticism and interpretation
- Language: English
- Type: Thesis , Doctoral , MBA
- Identifier: http://hdl.handle.net/10948/20087 , vital:29105
- Description: Olu phando luza kuphendla ukusetyenziswa kweenkumbulo nokulibala ngabalinganiswa kwiincwadi ezichongiweyo zesiXhosa. Apha kuvezwa ukuba iinkumbulo zinika umkhombandlela womakwenziwe. Kuza kugocwagocwa ezi ncwadi zilandelayo: Ingalo ngokubhalwe ngu-K.S. Bongela Elundini loThukela ngokubhalwe ngu-J.J.R. Jolobe Ukuqhawuka kwembeleko ngokubhalwe ngu-D.M. Jongilanga Ingqumbo yeminyanya ngokubhalwe ngu-A.C. Jordan Bhota Nonceba ibhalwe ngu-B.B. Mafuya UMakhwekhwetha ngokubhalwe ngu-R.F. Mcimeli Umqol’ uphandle ngokubhalwe ngu-M.A.P. Ngani Umkhonto kaTshiwo ngokubhalwe ngu-M.A.P. Ngani Unyana womntu ngokubhalwe ngu- N.Saule Vuleka mhlaba ngokubhalwe nguN. Saule Imijelo yegazi ngokubhalwe ngu-Z.S. Zotwana Apha kwezi ncwadi kuza kuhlutywa ukuba ukukhumbula nokulibala luyasetyenziswa ngabantu abantetho isisiXhosa nokuba wonke umntu unazo iinkumbulo, ingaba ziinkumbulo ezimnandi okanye ezinxunguphalisayo. Isahluko sokuqala salo msebenzi siza kunika amagqabantshintshi ngolu phando. Esi sahluko siqulathe: - Ingabula-zigcawu - Iinjongo zophando - Imibuzo ekhokelele ekwenziweni kolu phando - Indlela yokwenza olu phando - Ukubaluleka kolu phando - Okuthethwa zezinye iingcali ngeenkumbulo nokulibala - Ingcaciso magama Isahluko sesibini siqulathe iingcingane yeenkumbulo, ingcingane yobume bengqondo kwakunye nengcingane yokuqonda. Kukwajongwe abasunguli bezi ngcingane nemisebenzi yabo. Isahluko sesithathu siqwalasele iinkumbulo nempembelelo yazo kwinkcubeko nasentlalweni kwiincwadi ezichongiweyo. Isahluko sesine sijonge iinkumbulo zembali yepolitiki eMzantsi Afrika. Isahluko sesihlanu sicubungula iinkumbulo nokulibala kwezomthetho. Isahluko sesithandathu nesisesokugqibela - sishwankathela iziphumo zophando kukwanikwa nezindululo.
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The further development, optimisation and application of a Yarn Dismantler
- Authors: Fassihi, Ali Akbar
- Date: 2012
- Subjects: Textile industry , Cotton yarn industry
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10452 , http://hdl.handle.net/10948/d1016066
- Description: The fibre properties of cotton, which vary widely according to genetic and environmental conditions, determine its price and textile processing performance and product quality. It is therefore hardly surprising that cotton fibre properties are routinely measured for trading and quality control purposes, with a great deal of research having been, and still being, devoted towards developing instruments which enable the various fibre properties to be measured rapidly and accurately. In many cases, it is also necessary to be able to measure properties of cotton fibres when they have already been converted into yarn and fabric form. To do so, the yarn has to be dismantled into its component fibres, preferably without significantly changing the fibre properties. This could only be done by manually untwisting the yarn and carefully extracting the fibres from the untwisted yarn, care being taken not to break or lose any fibres in the process. This is a time consuming, laborious and labour intensive process. In view of this, a „yarn dismantler‟ which could automatically, cost effectively and within acceptable time frames, dismantle a cotton yarn into its constituent fibres, without undue damage or changes to the fibres, was developed and patented. This thesis reports the results of research undertaken to further develop, evaluate and optimize the yarn dismantler into the final prototype, as well as those relating to its practical applications, including tracking changes in fibre properties during miniature and pilot scale processing, up to, and including the yarn stage. Initial research undertaken on the original bench and first prototype models indicated that, although they produced very promising results, certain improvements and modifications were necessary, if the dismantler was to perform in an efficient and operator friendly manner at the required speeds. These included changes in the axial position of the untwisting spindle and the perforated screen of the suction drum, increasing the air suction at the perforated drum, installing a new motor for the untwisting spindle drive, separating the drives to the different parts of the unit in order to control them independently, integrating a more effective steaming unit into the unit etc. It was found that the dismantling rate had to be set to equal about 95 percent of the original twist in the yarn, and that steaming of the dismantled (untwisted) yarn on the perforated drum was necessary in order to eliminate any twist liveliness (residual torque) in the dismantled yarn, and enable it to be handled and tested on the AFIS instrument. When the final prototype Yarn Dismantler was produced, incorporating all the above mentioned improvements, it functioned very well at dismantling speeds of at least 2m/min, enabling the length of yarn required for subsequent AFIS testing to be dismantled within an acceptable time of less than 10 minutes, with excellent reproducibility and repeatability of results, also under commercial conditions. It was found that the AFIS measured length characteristics of fibres from the instrument dismantled yarns compared very well with those of fibres from manually dismantled yarns, differences in fibre length generally being less than 1mm, and it was concluded from these and other evaluation tests, that the yarn dismantler produced fibres without any significant fibre breakage. Some limited tests, carried out on commercially produced carded and combed yarns, indicated that short fibre content and dust and trash levels, as measured by the AFIS on fibres from dismantled yarn, together with the corresponding Uster Statistics, could enable a carded cotton yarn to be distinguished from a combed cotton yarn. Statistical analysis of fibre test results obtained at the different stages during miniature and pilot plant scale processing of various cottons, clearly showed that very significant changes in fibre properties could be caused by certain of the processes. For example, significant fibre breakage occurred during the drafting on the spinning frame, prior to twist insertion. The thesis provides detailed results of changes in various fibre properties, including length, short fibre content, maturity, immature fibre content, seed coat neps and fibrous neps, which occurred from the lint to the final yarn, as well as on the relationship between the properties of the fibres from the dismantled yarn and those from the lint. The results obtained have clearly demonstrated the practical value of the yarn dismantler in enabling yarns to be automatically dismantled into their constituent fibres, which can then be tested by an instrument, such as the AFIS, and the test results related to those of the original lint fibres, thereby opening up many fields of research and practical applications, some of which are captured under „Recommended Further Work‟.
- Full Text:
- Authors: Fassihi, Ali Akbar
- Date: 2012
- Subjects: Textile industry , Cotton yarn industry
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:10452 , http://hdl.handle.net/10948/d1016066
- Description: The fibre properties of cotton, which vary widely according to genetic and environmental conditions, determine its price and textile processing performance and product quality. It is therefore hardly surprising that cotton fibre properties are routinely measured for trading and quality control purposes, with a great deal of research having been, and still being, devoted towards developing instruments which enable the various fibre properties to be measured rapidly and accurately. In many cases, it is also necessary to be able to measure properties of cotton fibres when they have already been converted into yarn and fabric form. To do so, the yarn has to be dismantled into its component fibres, preferably without significantly changing the fibre properties. This could only be done by manually untwisting the yarn and carefully extracting the fibres from the untwisted yarn, care being taken not to break or lose any fibres in the process. This is a time consuming, laborious and labour intensive process. In view of this, a „yarn dismantler‟ which could automatically, cost effectively and within acceptable time frames, dismantle a cotton yarn into its constituent fibres, without undue damage or changes to the fibres, was developed and patented. This thesis reports the results of research undertaken to further develop, evaluate and optimize the yarn dismantler into the final prototype, as well as those relating to its practical applications, including tracking changes in fibre properties during miniature and pilot scale processing, up to, and including the yarn stage. Initial research undertaken on the original bench and first prototype models indicated that, although they produced very promising results, certain improvements and modifications were necessary, if the dismantler was to perform in an efficient and operator friendly manner at the required speeds. These included changes in the axial position of the untwisting spindle and the perforated screen of the suction drum, increasing the air suction at the perforated drum, installing a new motor for the untwisting spindle drive, separating the drives to the different parts of the unit in order to control them independently, integrating a more effective steaming unit into the unit etc. It was found that the dismantling rate had to be set to equal about 95 percent of the original twist in the yarn, and that steaming of the dismantled (untwisted) yarn on the perforated drum was necessary in order to eliminate any twist liveliness (residual torque) in the dismantled yarn, and enable it to be handled and tested on the AFIS instrument. When the final prototype Yarn Dismantler was produced, incorporating all the above mentioned improvements, it functioned very well at dismantling speeds of at least 2m/min, enabling the length of yarn required for subsequent AFIS testing to be dismantled within an acceptable time of less than 10 minutes, with excellent reproducibility and repeatability of results, also under commercial conditions. It was found that the AFIS measured length characteristics of fibres from the instrument dismantled yarns compared very well with those of fibres from manually dismantled yarns, differences in fibre length generally being less than 1mm, and it was concluded from these and other evaluation tests, that the yarn dismantler produced fibres without any significant fibre breakage. Some limited tests, carried out on commercially produced carded and combed yarns, indicated that short fibre content and dust and trash levels, as measured by the AFIS on fibres from dismantled yarn, together with the corresponding Uster Statistics, could enable a carded cotton yarn to be distinguished from a combed cotton yarn. Statistical analysis of fibre test results obtained at the different stages during miniature and pilot plant scale processing of various cottons, clearly showed that very significant changes in fibre properties could be caused by certain of the processes. For example, significant fibre breakage occurred during the drafting on the spinning frame, prior to twist insertion. The thesis provides detailed results of changes in various fibre properties, including length, short fibre content, maturity, immature fibre content, seed coat neps and fibrous neps, which occurred from the lint to the final yarn, as well as on the relationship between the properties of the fibres from the dismantled yarn and those from the lint. The results obtained have clearly demonstrated the practical value of the yarn dismantler in enabling yarns to be automatically dismantled into their constituent fibres, which can then be tested by an instrument, such as the AFIS, and the test results related to those of the original lint fibres, thereby opening up many fields of research and practical applications, some of which are captured under „Recommended Further Work‟.
- Full Text:
Exploring the use of folktales to enhance the resilince of children orphaned and rendered vulnerable
- Authors: Mayaba, Nokhanyo Nomakhwezi
- Date: 2012
- Subjects: Narrative therapy , Resilience (Personality trait) in children -- South Africa , Loss (Psychology) in children , Children of AIDS patients -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:9513 , http://hdl.handle.net/10948/2776 , Narrative therapy , Resilience (Personality trait) in children -- South Africa , Loss (Psychology) in children , Children of AIDS patients -- South Africa
- Description: The recent increase in the number of children orphaned and rendered vulnerable by HIV and AIDS in South Africa has placed an added burden on schools as sites of care and support. Education policies mandate schools to develop strategies to support such children, but this is no easy task in contexts where teachers are already struggling to fulfill instructional requirements. Literature reveals that teachers in under-resourced schools, where the problem is more severely experienced regard this increased pastoral role as an added responsibility that they do not feel competent to execute. Since there is unlikely to be any significant improvement in the circumstances of these children in the near future, there is a need to discover creative ways to address this problem. I was led to ask how teachers could support children to better cope in the face of adversity in a way that could be easily integrated into the academic curriculum, so as to minimise the perceived burden of providing care and support. Based on my knowledge of the value of bibliotherapy in promoting resilient coping in individuals, I was interested to see if folktales could be used in a similar way with groups of children. Working from an asset-based perspective, and proceeding from a transformative and participatory epistemology, I adopted an action research design to explore the potential of traditional folktales to enhance positive coping responses in children orphaned and rendered vulnerable by HIV and AIDS. My choice of traditional folktales was influenced by the importance that resilience theory attaches to cultural variables in the resilience process. The participants were isiXhosa speaking children who were orphaned and rendered vulnerable by HIV and AIDS (OVC) between the ages of nine and fourteen years (n=30) in Cycle One who lived in a children‟s home or with foster parents. In Cycle Two, the study was conducted in a school setting with thirty (n=30) participants. I conducted two cycles of reflective action research enquiry to ascertain how folktales could be used to enable teachers to meet both pastoral and academic requirements. In the first cycle, I used a pre-post time series design to explore if merely telling the stories would enhance the resilience of the children. Although this use of the stories was teacher-centred, I knew that it would be an easy and time-saving way for teachers to provide support, if it proved to be effective in enhancing resilience. Drawings and accompanying explanations were used to generate data pre-and post-intervention. The thematic analysis of the data revealed that, post-intervention, there appeared to be an increase in two resilience-enhancing indicators: the children appeared to have a more positive sense of self and improved positive relations with peers/friends. Critical reflection on the process also revealed ethical and methodological concerns and problems when working with vulnerable children. The findings from this cycle informed my second cycle, in which I adopted a more participatory approach to engage the children in making meaning of the stories and explore how they related to their own lives. I used participatory arts based methods such as drawings, collages, drama and more usual qualitative strategies, such as focus group discussion and observation, to generate data. The findings from this cycle suggest that using such strategies will equip teachers with tools to enhance the resilience of OVC in a way that also promotes the attainment of instructional outcomes. This study has contributed important theoretical, methodological and pedagogical insights. Theoretically, this study has contributed to the social ecological perspective of resilience by confirming that cultural resources, such as indigenous African stories (folktales) can enhance the resilience of vulnerable children. Lessons learnt from this study had a methodological contribution to the ethics of working with children and the use of culturally appropriate resources in the field, which were folktales. This study has also contributed to the meaning making implications of using folktales, which can aid the pedagogical strategies that teachers use. Although this study was meant to be small- scale research and was not intended to be generalisable, the findings do suggest that teachers could have a resource that is time efficient, effective and could assist them to reach both their pastoral and academic goals.
- Full Text:
Exploring the use of folktales to enhance the resilince of children orphaned and rendered vulnerable
- Authors: Mayaba, Nokhanyo Nomakhwezi
- Date: 2012
- Subjects: Narrative therapy , Resilience (Personality trait) in children -- South Africa , Loss (Psychology) in children , Children of AIDS patients -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: vital:9513 , http://hdl.handle.net/10948/2776 , Narrative therapy , Resilience (Personality trait) in children -- South Africa , Loss (Psychology) in children , Children of AIDS patients -- South Africa
- Description: The recent increase in the number of children orphaned and rendered vulnerable by HIV and AIDS in South Africa has placed an added burden on schools as sites of care and support. Education policies mandate schools to develop strategies to support such children, but this is no easy task in contexts where teachers are already struggling to fulfill instructional requirements. Literature reveals that teachers in under-resourced schools, where the problem is more severely experienced regard this increased pastoral role as an added responsibility that they do not feel competent to execute. Since there is unlikely to be any significant improvement in the circumstances of these children in the near future, there is a need to discover creative ways to address this problem. I was led to ask how teachers could support children to better cope in the face of adversity in a way that could be easily integrated into the academic curriculum, so as to minimise the perceived burden of providing care and support. Based on my knowledge of the value of bibliotherapy in promoting resilient coping in individuals, I was interested to see if folktales could be used in a similar way with groups of children. Working from an asset-based perspective, and proceeding from a transformative and participatory epistemology, I adopted an action research design to explore the potential of traditional folktales to enhance positive coping responses in children orphaned and rendered vulnerable by HIV and AIDS. My choice of traditional folktales was influenced by the importance that resilience theory attaches to cultural variables in the resilience process. The participants were isiXhosa speaking children who were orphaned and rendered vulnerable by HIV and AIDS (OVC) between the ages of nine and fourteen years (n=30) in Cycle One who lived in a children‟s home or with foster parents. In Cycle Two, the study was conducted in a school setting with thirty (n=30) participants. I conducted two cycles of reflective action research enquiry to ascertain how folktales could be used to enable teachers to meet both pastoral and academic requirements. In the first cycle, I used a pre-post time series design to explore if merely telling the stories would enhance the resilience of the children. Although this use of the stories was teacher-centred, I knew that it would be an easy and time-saving way for teachers to provide support, if it proved to be effective in enhancing resilience. Drawings and accompanying explanations were used to generate data pre-and post-intervention. The thematic analysis of the data revealed that, post-intervention, there appeared to be an increase in two resilience-enhancing indicators: the children appeared to have a more positive sense of self and improved positive relations with peers/friends. Critical reflection on the process also revealed ethical and methodological concerns and problems when working with vulnerable children. The findings from this cycle informed my second cycle, in which I adopted a more participatory approach to engage the children in making meaning of the stories and explore how they related to their own lives. I used participatory arts based methods such as drawings, collages, drama and more usual qualitative strategies, such as focus group discussion and observation, to generate data. The findings from this cycle suggest that using such strategies will equip teachers with tools to enhance the resilience of OVC in a way that also promotes the attainment of instructional outcomes. This study has contributed important theoretical, methodological and pedagogical insights. Theoretically, this study has contributed to the social ecological perspective of resilience by confirming that cultural resources, such as indigenous African stories (folktales) can enhance the resilience of vulnerable children. Lessons learnt from this study had a methodological contribution to the ethics of working with children and the use of culturally appropriate resources in the field, which were folktales. This study has also contributed to the meaning making implications of using folktales, which can aid the pedagogical strategies that teachers use. Although this study was meant to be small- scale research and was not intended to be generalisable, the findings do suggest that teachers could have a resource that is time efficient, effective and could assist them to reach both their pastoral and academic goals.
- Full Text: