A co-constructed practice model for supporting parents of children in conflict with the law
- Authors: Abdulla, Zurina
- Date: 2019
- Subjects: Children's rights -- South Africa , Children -- Legal status, laws, etc --South Africa , Parent and child -- Research -- South Africa , Social work with youth -- South Africa
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: http://hdl.handle.net/10948/30474 , vital:30949
- Description: The unique historical stressors linked to South Africa’s apartheid legacy, continues to manifest in the form of economic exclusion, social exclusion, inequality and poverty, with parents being subjugated to service users and extenders rather than included as service advocates, particularly in the child justice system. Furthermore, policies and practices do not include, engage and support parents on an intra and interpersonal level. Parents of children in conflict with the law, experience their children’s charge or arrest as well as their subsequent journey through the child justice system as a crisis resulting in their need for emotional, informational, practical and professional support during the child justice process. The similarities and differences between the contexts of child protection and child justice in supporting parents illuminates the existing gaps in child justice legislation, policy and practice resulting in a lack of support for parents during the child justice process. In the Children’s Act 38 of 2005, it is recognised that parents have a legal responsibility towards their children and that in fulfilling this responsibility parents can access support services to assist them when they face challenges in fulfilling this responsibility. In contrast, despite 80 percent of children in conflict with the law being released into parental care and parents expressing the need for support in fulfilling their parental responsibility, in this regard the Child Justice Act 75 of 2008 fails to make provision for parents to access support services. The child justice system’s narrow focus on parents as service extenders contributes to parents’ being excluded from targeted support services resulting in parents’ support needs not being addressed. The lack of programmes and services aimed at supporting parents highlight the need for coordinated services that address the multiple stressors parents are exposed to. To this end, this study was aimed at coconstructing a practice model for supporting parents of children in conflict with the law. The theoretical lenses employed in the current study namely; the Ecological systems model and the Buffering effect model describes the various systems parents need support from and the type of support they need from their family, community and professionals. Guided by a qualitative approach, the present study integrated applied research, in particular intervention design and development with participatory action research as it allowed systematic collaboration during the research process to ensure rigour. This study involved participants from two research sites namely, the Nerina One- Stop Child Justice Centre in Port Elizabeth and the Reception, Assessment and Referral office at the Uitenhage magistrates’ court. Employing a non-probability purposive sampling method, this study facilitated the participation of parents of children in conflict with the law and child justice officials who met the inclusion criteria, in the co-design and development of a practice model for supporting parents of children in conflict with the law. Participants assumed an expert and collaborative role, which enabled the co-construction of knowledge, meaning and innovation of the practice model. Qualitative data collection methods namely, twelve focus groups and thirty two participant observations, were used to explore, co-construct, describe and design a practice model for supporting parents of children in conflict with the law during the child justice process. Thematic analyses was employed to condense the data, search for codes, categories, themes, relationships and patterns in the data. Due to the research approach and design, data analysis was ongoing and informed design and development of the practice model. Based on the thematic analysis and synthesis both descriptive and analytic themes emerged. To ensure trustworthiness, this study employed various strategies to strengthen commitment, rigour, transparency and coherence. In addition, the participative research process, the inclusion of multiple forms of qualitative inquiry and the significance of the study contributed to the validity and quality of the study. Ethical considerations applicable to the study included participants’ voluntary participation, their informed consent and ensuring participants’ privacy or maintaining confidentially. Various strategies were employed to prevent or minimise risk to participants. The findings showed that formal sources of support, in particular, offer opportunities for parents to access individual and family counselling, parenting advice, and peer support. The study also highlighted the importance of recognising parents as a subsystem in the child justice system offers potential opportunities for inclusion of parents as co-facilitators of parenting programmes or support groups, as peer supporters during the child justice process. Parents’ inclusion as a partner in the child justice system is highlighted as an opportunity for parents to be able to vi participate in child justice fora, oversight committees and accreditation committees to influence policy, services and budget allocations for services to support parents of children in conflict with the law. This study’s contribution to the existing body of knowledge is an integrated, multidisciplinary, multi-phase co-constructed practice model that would enable inclusion of, and support for, parents of children in conflict with the law prior to, during and after the child justice. The co-constructed practice model (a) involves a continuum of parent-centred support for and inclusion of parents prior to, during and after the child justice process; (b) advances an inclusive and collaborative child justice system that views parents as important stakeholders in determining the type of services they need and being involved in developing practice; and (c) promotes parents as equal partners in decision making and policy making to influence legislation, policy and practice in the child justice system.
- Full Text:
- Date Issued: 2019
- Authors: Abdulla, Zurina
- Date: 2019
- Subjects: Children's rights -- South Africa , Children -- Legal status, laws, etc --South Africa , Parent and child -- Research -- South Africa , Social work with youth -- South Africa
- Language: English
- Type: Thesis , Doctoral , DPhil
- Identifier: http://hdl.handle.net/10948/30474 , vital:30949
- Description: The unique historical stressors linked to South Africa’s apartheid legacy, continues to manifest in the form of economic exclusion, social exclusion, inequality and poverty, with parents being subjugated to service users and extenders rather than included as service advocates, particularly in the child justice system. Furthermore, policies and practices do not include, engage and support parents on an intra and interpersonal level. Parents of children in conflict with the law, experience their children’s charge or arrest as well as their subsequent journey through the child justice system as a crisis resulting in their need for emotional, informational, practical and professional support during the child justice process. The similarities and differences between the contexts of child protection and child justice in supporting parents illuminates the existing gaps in child justice legislation, policy and practice resulting in a lack of support for parents during the child justice process. In the Children’s Act 38 of 2005, it is recognised that parents have a legal responsibility towards their children and that in fulfilling this responsibility parents can access support services to assist them when they face challenges in fulfilling this responsibility. In contrast, despite 80 percent of children in conflict with the law being released into parental care and parents expressing the need for support in fulfilling their parental responsibility, in this regard the Child Justice Act 75 of 2008 fails to make provision for parents to access support services. The child justice system’s narrow focus on parents as service extenders contributes to parents’ being excluded from targeted support services resulting in parents’ support needs not being addressed. The lack of programmes and services aimed at supporting parents highlight the need for coordinated services that address the multiple stressors parents are exposed to. To this end, this study was aimed at coconstructing a practice model for supporting parents of children in conflict with the law. The theoretical lenses employed in the current study namely; the Ecological systems model and the Buffering effect model describes the various systems parents need support from and the type of support they need from their family, community and professionals. Guided by a qualitative approach, the present study integrated applied research, in particular intervention design and development with participatory action research as it allowed systematic collaboration during the research process to ensure rigour. This study involved participants from two research sites namely, the Nerina One- Stop Child Justice Centre in Port Elizabeth and the Reception, Assessment and Referral office at the Uitenhage magistrates’ court. Employing a non-probability purposive sampling method, this study facilitated the participation of parents of children in conflict with the law and child justice officials who met the inclusion criteria, in the co-design and development of a practice model for supporting parents of children in conflict with the law. Participants assumed an expert and collaborative role, which enabled the co-construction of knowledge, meaning and innovation of the practice model. Qualitative data collection methods namely, twelve focus groups and thirty two participant observations, were used to explore, co-construct, describe and design a practice model for supporting parents of children in conflict with the law during the child justice process. Thematic analyses was employed to condense the data, search for codes, categories, themes, relationships and patterns in the data. Due to the research approach and design, data analysis was ongoing and informed design and development of the practice model. Based on the thematic analysis and synthesis both descriptive and analytic themes emerged. To ensure trustworthiness, this study employed various strategies to strengthen commitment, rigour, transparency and coherence. In addition, the participative research process, the inclusion of multiple forms of qualitative inquiry and the significance of the study contributed to the validity and quality of the study. Ethical considerations applicable to the study included participants’ voluntary participation, their informed consent and ensuring participants’ privacy or maintaining confidentially. Various strategies were employed to prevent or minimise risk to participants. The findings showed that formal sources of support, in particular, offer opportunities for parents to access individual and family counselling, parenting advice, and peer support. The study also highlighted the importance of recognising parents as a subsystem in the child justice system offers potential opportunities for inclusion of parents as co-facilitators of parenting programmes or support groups, as peer supporters during the child justice process. Parents’ inclusion as a partner in the child justice system is highlighted as an opportunity for parents to be able to vi participate in child justice fora, oversight committees and accreditation committees to influence policy, services and budget allocations for services to support parents of children in conflict with the law. This study’s contribution to the existing body of knowledge is an integrated, multidisciplinary, multi-phase co-constructed practice model that would enable inclusion of, and support for, parents of children in conflict with the law prior to, during and after the child justice. The co-constructed practice model (a) involves a continuum of parent-centred support for and inclusion of parents prior to, during and after the child justice process; (b) advances an inclusive and collaborative child justice system that views parents as important stakeholders in determining the type of services they need and being involved in developing practice; and (c) promotes parents as equal partners in decision making and policy making to influence legislation, policy and practice in the child justice system.
- Full Text:
- Date Issued: 2019
Conjuring our beings: Stacey Gillian Abe and Immy Mali in conversational partnership
- Abe, Stacey Gillian, Mali, Immy
- Authors: Abe, Stacey Gillian , Mali, Immy
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/145963 , vital:38482 , https://0-doi.org.wam.seals.ac.za/10.1162/afar_a_00457
- Description: The series of Conversational Partnerships began in 2017 in African Arts vol. 50, no. 2, with a conversation between two artists: Eria Nsubuga SANE from Uganda and Sikhumbuzo Makandula from South Africa. The format of a “conversational partnership” (Rubin and Rubin 2012: 7) emphasizes the cocreation of meaning by the interviewer and interviewee as coauthors. This enables a move away from the art history format of the interviewer (usually a writer) assuming the role of the sole author and the interviewee (often an artist) having no status as an author despite the fact that her or his practice-led creation of knowledge is foundational to the content of the interview. Stacey Gillian Abe and Immy Mali participated in a joint artists' residency as part of the RAW program at Rhodes University in South Africa from November to December 2017. During this time, they engaged with each other's practice-led work, and they created this conversational partnership at a writing breakaway in the Eastern Cape.
- Full Text:
- Date Issued: 2019
- Authors: Abe, Stacey Gillian , Mali, Immy
- Date: 2019
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/145963 , vital:38482 , https://0-doi.org.wam.seals.ac.za/10.1162/afar_a_00457
- Description: The series of Conversational Partnerships began in 2017 in African Arts vol. 50, no. 2, with a conversation between two artists: Eria Nsubuga SANE from Uganda and Sikhumbuzo Makandula from South Africa. The format of a “conversational partnership” (Rubin and Rubin 2012: 7) emphasizes the cocreation of meaning by the interviewer and interviewee as coauthors. This enables a move away from the art history format of the interviewer (usually a writer) assuming the role of the sole author and the interviewee (often an artist) having no status as an author despite the fact that her or his practice-led creation of knowledge is foundational to the content of the interview. Stacey Gillian Abe and Immy Mali participated in a joint artists' residency as part of the RAW program at Rhodes University in South Africa from November to December 2017. During this time, they engaged with each other's practice-led work, and they created this conversational partnership at a writing breakaway in the Eastern Cape.
- Full Text:
- Date Issued: 2019
Acculturation and Coming of age in female African writing; a Freudian psychoanalysis of Tsitsi Dangarembga’s Nervous Conditions and Chimamada Adichie’s Purple Hibiscus
- Authors: Abiodun, Adedoyin Catherine
- Date: 2019
- Subjects: African literature (English)
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10353/16274 , vital:40704
- Description: This study explores Acculturation and Coming of age not only as a social process but also a psychological one. The constructs are examined in line with Freudian psychoanalytic theory. The study focuses on migrant inclination of two female African writers, Tsitsi Dangarembga and Chimamanda Adichie in Nervous Conditions and Purple Hibiscus respectively. Through the study, it is discovered that acculturation involves both cultural and psychological change or adaptation and failure in either can result in trauma or produce socially imbalanced individuals. In other to have a healthy coming of age, family and the home status play a very significant role in the totality of an individual and also serves as a microcosm of social and political milieu. Also, the study in the course of the study, we discover there is no ‘authentic African culture’, culture is non-static and so, the study also discusses culture as being transnational and translational. The writers’ consciousness of space and place in their writing through reminiscent times of childhood play significant roles. Childhood figures are constructed in a matrix of concrete memories, spaces, places and times that play a significant role in the production of meanings of their migrant identities. The study identifies ways in which female socialisation further enhances her marginalisation in the society and how the family in the African setting as an ideological state apparatus contributes in ensuring the marginalised position of women. The authors being studied interrogate methods of raising children among African families in contemporary society
- Full Text:
- Date Issued: 2019
- Authors: Abiodun, Adedoyin Catherine
- Date: 2019
- Subjects: African literature (English)
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10353/16274 , vital:40704
- Description: This study explores Acculturation and Coming of age not only as a social process but also a psychological one. The constructs are examined in line with Freudian psychoanalytic theory. The study focuses on migrant inclination of two female African writers, Tsitsi Dangarembga and Chimamanda Adichie in Nervous Conditions and Purple Hibiscus respectively. Through the study, it is discovered that acculturation involves both cultural and psychological change or adaptation and failure in either can result in trauma or produce socially imbalanced individuals. In other to have a healthy coming of age, family and the home status play a very significant role in the totality of an individual and also serves as a microcosm of social and political milieu. Also, the study in the course of the study, we discover there is no ‘authentic African culture’, culture is non-static and so, the study also discusses culture as being transnational and translational. The writers’ consciousness of space and place in their writing through reminiscent times of childhood play significant roles. Childhood figures are constructed in a matrix of concrete memories, spaces, places and times that play a significant role in the production of meanings of their migrant identities. The study identifies ways in which female socialisation further enhances her marginalisation in the society and how the family in the African setting as an ideological state apparatus contributes in ensuring the marginalised position of women. The authors being studied interrogate methods of raising children among African families in contemporary society
- Full Text:
- Date Issued: 2019
The protection against child labour in South Africa
- Authors: Abrahams, Collis
- Date: 2019
- Subjects: Child labor
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: http://hdl.handle.net/10948/40204 , vital:35986
- Description: This treatise seeks to describe the legal protection of children against child labour in South Africa. It does so within the context of international-law-protection in the form of Conventions of the International Labour Organisation. The treatise distinguishes between the concepts of child labour and child work and traces the history of international law prohibiting and regulating child labour. The two most important ILO Conventions, Convention 138 of 1973 and 182 of 1998 are considered in some detail before the national legislature is explained and analysed. From the discussion it is apparent that South Africa is giving effect to the applicable ILO Conventions. Not only does national legislation prohibit child labour, the state also adopted nation-wide programmes to eradicate child labour. Despite the efforts there is still room for improvement. The fight to eradicate child labour must continue!
- Full Text:
- Date Issued: 2019
- Authors: Abrahams, Collis
- Date: 2019
- Subjects: Child labor
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: http://hdl.handle.net/10948/40204 , vital:35986
- Description: This treatise seeks to describe the legal protection of children against child labour in South Africa. It does so within the context of international-law-protection in the form of Conventions of the International Labour Organisation. The treatise distinguishes between the concepts of child labour and child work and traces the history of international law prohibiting and regulating child labour. The two most important ILO Conventions, Convention 138 of 1973 and 182 of 1998 are considered in some detail before the national legislature is explained and analysed. From the discussion it is apparent that South Africa is giving effect to the applicable ILO Conventions. Not only does national legislation prohibit child labour, the state also adopted nation-wide programmes to eradicate child labour. Despite the efforts there is still room for improvement. The fight to eradicate child labour must continue!
- Full Text:
- Date Issued: 2019
Fluorescence “turn-ON” nanosensor for cyanide ion using supramolecular hybrid of graphene quantum dots and cobalt pyrene-derivatized phthalocyanine
- Achadu, Ojodomo John, Nyokong, Tebello
- Authors: Achadu, Ojodomo John , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/187594 , vital:44674 , xlink:href="https://doi.org/10.1016/j.dyepig.2018.08.038"
- Description: A functional hybrid of graphene quantum dots (GQDs) and cobalt pyrene-derivatized phthalocyanine (CoPc) used as a sensitive nanoprobe for the recognition of cyanide ion (CN−) is described in this work. The fluorescence of GQDs was quenched upon non-covalent (π-π stacking) hybrid formation with CoPc via a possible energy transfer pathway. However, in the presence of CN−, the interaction between GQDs and CoPc was perturbed, such that the fluorescence of GQDs initially quenched by CoPc was found to be efficiently recovered in the presence of CN−. Amongst the molecules and anions tested to ascertain their effects on the fluorescence behaviour of the hybrid, only CN− ion induced the tunable “off-on” restoration of the fluorescence of GQDs, which demonstrates the selectivity of the hybrid towards CN−. The restored fluorescence signals of the GQDs were linearly modulated by different concentrations of CN− and were used for the quantitative assay of CN− with high sensitivity coupled with rapid detection time. The detection was in the linear range of 1.0–50.0 nM with limits of detection (LOD) of 0.5 nM. The analysis of spiked samples for the recovery of CN− further demonstrated the applicability of the hybrid for the satisfactory detection of the target analyte.
- Full Text:
- Date Issued: 2019
- Authors: Achadu, Ojodomo John , Nyokong, Tebello
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/187594 , vital:44674 , xlink:href="https://doi.org/10.1016/j.dyepig.2018.08.038"
- Description: A functional hybrid of graphene quantum dots (GQDs) and cobalt pyrene-derivatized phthalocyanine (CoPc) used as a sensitive nanoprobe for the recognition of cyanide ion (CN−) is described in this work. The fluorescence of GQDs was quenched upon non-covalent (π-π stacking) hybrid formation with CoPc via a possible energy transfer pathway. However, in the presence of CN−, the interaction between GQDs and CoPc was perturbed, such that the fluorescence of GQDs initially quenched by CoPc was found to be efficiently recovered in the presence of CN−. Amongst the molecules and anions tested to ascertain their effects on the fluorescence behaviour of the hybrid, only CN− ion induced the tunable “off-on” restoration of the fluorescence of GQDs, which demonstrates the selectivity of the hybrid towards CN−. The restored fluorescence signals of the GQDs were linearly modulated by different concentrations of CN− and were used for the quantitative assay of CN− with high sensitivity coupled with rapid detection time. The detection was in the linear range of 1.0–50.0 nM with limits of detection (LOD) of 0.5 nM. The analysis of spiked samples for the recovery of CN− further demonstrated the applicability of the hybrid for the satisfactory detection of the target analyte.
- Full Text:
- Date Issued: 2019
Effect of school-based interventions on attention and academic performance of primary schoolchildren from lower socioeconomic communities in Port Elizabeth
- Authors: Adams, Larissa
- Date: 2019
- Subjects: Academic achievement -- South Africa , Exercise -- Physiological aspects Physical education for children Physical education and training
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/42085 , vital:36624
- Description: Health benefits associated with regular physical activity (PA) have been widely established. Regular PA is not only associated with improved physical and psychological well-being, but also with improved brain function and cognition, thereby enhancing academic performance (AP). Despite these benefits, decreasing levels of PA and increasing levels of overweight and obesity exist world-wide, making childhood physical inactivity a global concern. Research suggests children who meet the recommended PA guidelines of 60-minutes of moderate-to-vigorous intensity attain substantially higher academic grades. Schools provide ideal settings for PA promotion due to the substantial amount of time children spend at school. However, in many countries, including South Africa (SA), Physical Education (PE) programmes have been reduced and replaced with other subjects to increase AP. Furthermore, a scarcity of water, limited accessibility to improved sanitation and lack of personal hygiene at home and in school substantially contributes to the burden of preventable childhood diseases. These hygiene-related illnesses augment the cycle of poverty and disease through its detrimental effect on children’s school attendance, academic performance and productivity. Studies also show that obesity, poor nutrition and food insufficiency affect children’s school achievement. Hence, the school environment plays an essential role in improving children’s health, since many teaching opportunities about important health and nutrition practices are provided. The primary aim of this study was to determine the effect of various combinations of school-based interventions on the attention and AP of primary schoolchildren from disadvantaged communities in Port Elizabeth. Overall, 857 schoolchildren (n = 434 boys and n = 423 girls, aged 8 – 13 years) participated in the study. A 10-week cluster randomised controlled trial using four experimental and four control schools was conducted. Setting-specific interventions incorporated PA, health and hygiene education and nutrition components. The d2 Test of Attention measured selective visual attention and concentration with outcome measures of the percentage of errors, total performance and concentration performance. End of year school results were used to assess AP. Post-intervention and pre- to post-intervention differences between the inter-school comparisons revealed mixed results for the attention and AP measurements, therefore, no conclusions could be drawn regarding the assessed variables. Intervention group comparisons at post-intervention indicated that the PA intervention group achieved a statistically significant improvement (p < .05 and d > 0.8) for AP, when compared with the non-PA intervention group. No significant differences were found for AP in relation to intervention group comparisons for the health and hygiene education and nutrition intervention groups. Similarly, the intervention group comparisons revealed no significant differences regarding attention for post-intervention and pre- to post-intervention differences. Findings suggest that a school-based PA intervention can positively affect children’s AP. The current study emphasises the necessity of PA and reinforces the importance of PE in the school curriculum. Therefore, it is strongly recommended that PE regains its rightful place and be actively taught within the school curriculum.
- Full Text:
- Date Issued: 2019
- Authors: Adams, Larissa
- Date: 2019
- Subjects: Academic achievement -- South Africa , Exercise -- Physiological aspects Physical education for children Physical education and training
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/42085 , vital:36624
- Description: Health benefits associated with regular physical activity (PA) have been widely established. Regular PA is not only associated with improved physical and psychological well-being, but also with improved brain function and cognition, thereby enhancing academic performance (AP). Despite these benefits, decreasing levels of PA and increasing levels of overweight and obesity exist world-wide, making childhood physical inactivity a global concern. Research suggests children who meet the recommended PA guidelines of 60-minutes of moderate-to-vigorous intensity attain substantially higher academic grades. Schools provide ideal settings for PA promotion due to the substantial amount of time children spend at school. However, in many countries, including South Africa (SA), Physical Education (PE) programmes have been reduced and replaced with other subjects to increase AP. Furthermore, a scarcity of water, limited accessibility to improved sanitation and lack of personal hygiene at home and in school substantially contributes to the burden of preventable childhood diseases. These hygiene-related illnesses augment the cycle of poverty and disease through its detrimental effect on children’s school attendance, academic performance and productivity. Studies also show that obesity, poor nutrition and food insufficiency affect children’s school achievement. Hence, the school environment plays an essential role in improving children’s health, since many teaching opportunities about important health and nutrition practices are provided. The primary aim of this study was to determine the effect of various combinations of school-based interventions on the attention and AP of primary schoolchildren from disadvantaged communities in Port Elizabeth. Overall, 857 schoolchildren (n = 434 boys and n = 423 girls, aged 8 – 13 years) participated in the study. A 10-week cluster randomised controlled trial using four experimental and four control schools was conducted. Setting-specific interventions incorporated PA, health and hygiene education and nutrition components. The d2 Test of Attention measured selective visual attention and concentration with outcome measures of the percentage of errors, total performance and concentration performance. End of year school results were used to assess AP. Post-intervention and pre- to post-intervention differences between the inter-school comparisons revealed mixed results for the attention and AP measurements, therefore, no conclusions could be drawn regarding the assessed variables. Intervention group comparisons at post-intervention indicated that the PA intervention group achieved a statistically significant improvement (p < .05 and d > 0.8) for AP, when compared with the non-PA intervention group. No significant differences were found for AP in relation to intervention group comparisons for the health and hygiene education and nutrition intervention groups. Similarly, the intervention group comparisons revealed no significant differences regarding attention for post-intervention and pre- to post-intervention differences. Findings suggest that a school-based PA intervention can positively affect children’s AP. The current study emphasises the necessity of PA and reinforces the importance of PE in the school curriculum. Therefore, it is strongly recommended that PE regains its rightful place and be actively taught within the school curriculum.
- Full Text:
- Date Issued: 2019
An investigation of the challenges and their impacts as experienced by experts at the forensic pathology services in Port Elizabeth, South Africa
- Authors: Adams, Terry
- Date: 2019
- Subjects: Forensic pathology
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/40213 , vital:35985
- Description: This study focuses on the challenges facing the workers at the Port Elizabeth Forensic Pathology Services in Gelvandale and Mount Road stations. The study follow a qualitative approach which include among others, individual interviews using an interview guide containing questions. Observation has also been used as a research tool to observe at the two stations. To supplement the above research techniques, scholarly published journal articles and books were consulted to corroborate what might have transpired in other studies similar to this one. The concept backlog has been used as a conceptual framework to understand the challenges facing the workers in this study and relevant literature has been consulted. The research finding has been outlined and finally recommendations has been made with the view of addressing some of the problems encountered by the workers.
- Full Text:
- Date Issued: 2019
- Authors: Adams, Terry
- Date: 2019
- Subjects: Forensic pathology
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/40213 , vital:35985
- Description: This study focuses on the challenges facing the workers at the Port Elizabeth Forensic Pathology Services in Gelvandale and Mount Road stations. The study follow a qualitative approach which include among others, individual interviews using an interview guide containing questions. Observation has also been used as a research tool to observe at the two stations. To supplement the above research techniques, scholarly published journal articles and books were consulted to corroborate what might have transpired in other studies similar to this one. The concept backlog has been used as a conceptual framework to understand the challenges facing the workers in this study and relevant literature has been consulted. The research finding has been outlined and finally recommendations has been made with the view of addressing some of the problems encountered by the workers.
- Full Text:
- Date Issued: 2019
On-site evaluation of smoking, alcohol consumption and physical inactivity among commercial taxi drivers in Buffalo City Metropolitan Municipality, South Africa
- Adedokun, Aanuoluwa Odunayo, Ter Goon, Daniel, Owolabi, Eyitayo Omolara, Adeniyi, Oladele Vincent, Ajayi, Anthony Idowu
- Authors: Adedokun, Aanuoluwa Odunayo , Ter Goon, Daniel , Owolabi, Eyitayo Omolara , Adeniyi, Oladele Vincent , Ajayi, Anthony Idowu
- Date: 2019
- Subjects: Alcohol use , Substance use , Commercial drivers
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/11260/5086 , vital:44345 , https://doi.org/10.5539/gjhs.v11n2p110
- Description: Commercial drivers have been identified as eliciting behaviours that promote non- communicable diseases and road traffic accidents. The aim of the study is to determine the prevalence and pattern of alcohol use, smoking and physical inactivity among commercial taxi drivers in Buffalo City Metropolitan Municipality, South Africa. A cross-sectional study was conducted among 403 commercial drivers using the face-to-face interviews method. The WHO STEPwise questionnaire was used to obtain the demographic data, self-reported rate of alcohol consumption, tobacco use and physical inactivity. The participants’ mean age was 43.3 ± 12.5 years. About 30% of the participants were daily smokers, 37% consumed alcohol regularly and only 18% were physically active, whilst 82% were physically inactive. The prevalence of alcohol use, smoking and physical inactivity is high among commercial drivers in East London. Workplace health education on the health effects of these lifestyles’ risky behaviours on individuals and the general public should be given to the drivers.
- Full Text:
- Date Issued: 2019
- Authors: Adedokun, Aanuoluwa Odunayo , Ter Goon, Daniel , Owolabi, Eyitayo Omolara , Adeniyi, Oladele Vincent , Ajayi, Anthony Idowu
- Date: 2019
- Subjects: Alcohol use , Substance use , Commercial drivers
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/11260/5086 , vital:44345 , https://doi.org/10.5539/gjhs.v11n2p110
- Description: Commercial drivers have been identified as eliciting behaviours that promote non- communicable diseases and road traffic accidents. The aim of the study is to determine the prevalence and pattern of alcohol use, smoking and physical inactivity among commercial taxi drivers in Buffalo City Metropolitan Municipality, South Africa. A cross-sectional study was conducted among 403 commercial drivers using the face-to-face interviews method. The WHO STEPwise questionnaire was used to obtain the demographic data, self-reported rate of alcohol consumption, tobacco use and physical inactivity. The participants’ mean age was 43.3 ± 12.5 years. About 30% of the participants were daily smokers, 37% consumed alcohol regularly and only 18% were physically active, whilst 82% were physically inactive. The prevalence of alcohol use, smoking and physical inactivity is high among commercial drivers in East London. Workplace health education on the health effects of these lifestyles’ risky behaviours on individuals and the general public should be given to the drivers.
- Full Text:
- Date Issued: 2019
Beyond health care providers’recommendations: understandinginfluences on infant feeding choices ofwomen with HIV in the Eastern Cape,South Africa
- Adeniyi, Oladele Vincent, Ajayi, Anthony Idowu, Issah, Moshood, Owolabi, Eyitayo Omolara, Ter Goon, Daniel, Avramovic, Gordana, Lambert, John
- Authors: Adeniyi, Oladele Vincent , Ajayi, Anthony Idowu , Issah, Moshood , Owolabi, Eyitayo Omolara , Ter Goon, Daniel , Avramovic, Gordana , Lambert, John
- Date: 2017
- Subjects: Africa Infant Feeding Sub-sahara
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6063 , vital:45109 , https://doi.org/10.1186/s13006-019-0201-5
- Description: Background: Despite the array of studies on infant feeding practices of HIV-infected women, gaps still exist in the understanding of the underlying reasons for their infant feeding choices. Potential for behavioural change exists, especially in the light of the 2016 updated World Health Organization guideline on HIV and infant feeding. The aim of this paper is to determine the rate of adoption of exclusive breastfeeding in this cohort, examine the determinants of infant feeding choices of HIV-infected women and assess the underlying reasons for these choices. Methods: This was a mixed methods study conducted between September 2015 and May 2016. It analyses the quantitative and qualitative data of 1662 peripartum women enrolled in the East London Prospective Cohort Study across three large maternity services in the Eastern Cape. Women with HIV reported their preferred choices of infant feeding. In addition, participants explained the underlying reasons for their choices. Descriptive and inferential statistics summarised the quantitative data, while thematic content analysis was performed on qualitative data. Results: Of the 1662 women with complete responses, 80.3% opted to exclusively breastfeed their babies. In the adjusted model, up to grade 12 education level (AOR: 1.81; 95% CI: 1.14, 2.86), rural/peri-urban residence (AOR:1.44; 95% CI: 1.05, 1.96), alcohol use (AOR: 1.65; 95% CI: 1.25, 2.18), negative or unknown HIV status at booking (AOR:1.85; 95% CI:1.27, 2.70), currently married (AOR:1.43; 95% CI:1.01, 2.02) and WHO Clinical Stage 2–4 (AOR:1.77; 95% CI: 1.15, 2.72) were significantly associated with the decision to exclusively breastfeed. Health care providers’ recommendations, perceived benefits of breastfeeding, unaffordability of formula feeding, and coercion were the underlying reasons for wanting to breastfeed; while work/school-related demands, breast-related issues, and fear of infecting the baby influenced their decision to formula feed. Conclusion: The majority of HIV-infected women chose to breastfeed their babies in the Eastern Cape. Following up on these women to ensure they breastfeed exclusively, while also addressing their possible concerns, could be an important policy intervention. Future studies should focus on how early infant feeding decisions change over time, as well as the health outcomes for mother and child. Keywords: Exclusive breastfeeding, Infant feeding practice, infant formula feeding, HIV-infected peripartum women, South Africa, WHO guideline
- Full Text:
- Date Issued: 2017
- Authors: Adeniyi, Oladele Vincent , Ajayi, Anthony Idowu , Issah, Moshood , Owolabi, Eyitayo Omolara , Ter Goon, Daniel , Avramovic, Gordana , Lambert, John
- Date: 2017
- Subjects: Africa Infant Feeding Sub-sahara
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6063 , vital:45109 , https://doi.org/10.1186/s13006-019-0201-5
- Description: Background: Despite the array of studies on infant feeding practices of HIV-infected women, gaps still exist in the understanding of the underlying reasons for their infant feeding choices. Potential for behavioural change exists, especially in the light of the 2016 updated World Health Organization guideline on HIV and infant feeding. The aim of this paper is to determine the rate of adoption of exclusive breastfeeding in this cohort, examine the determinants of infant feeding choices of HIV-infected women and assess the underlying reasons for these choices. Methods: This was a mixed methods study conducted between September 2015 and May 2016. It analyses the quantitative and qualitative data of 1662 peripartum women enrolled in the East London Prospective Cohort Study across three large maternity services in the Eastern Cape. Women with HIV reported their preferred choices of infant feeding. In addition, participants explained the underlying reasons for their choices. Descriptive and inferential statistics summarised the quantitative data, while thematic content analysis was performed on qualitative data. Results: Of the 1662 women with complete responses, 80.3% opted to exclusively breastfeed their babies. In the adjusted model, up to grade 12 education level (AOR: 1.81; 95% CI: 1.14, 2.86), rural/peri-urban residence (AOR:1.44; 95% CI: 1.05, 1.96), alcohol use (AOR: 1.65; 95% CI: 1.25, 2.18), negative or unknown HIV status at booking (AOR:1.85; 95% CI:1.27, 2.70), currently married (AOR:1.43; 95% CI:1.01, 2.02) and WHO Clinical Stage 2–4 (AOR:1.77; 95% CI: 1.15, 2.72) were significantly associated with the decision to exclusively breastfeed. Health care providers’ recommendations, perceived benefits of breastfeeding, unaffordability of formula feeding, and coercion were the underlying reasons for wanting to breastfeed; while work/school-related demands, breast-related issues, and fear of infecting the baby influenced their decision to formula feed. Conclusion: The majority of HIV-infected women chose to breastfeed their babies in the Eastern Cape. Following up on these women to ensure they breastfeed exclusively, while also addressing their possible concerns, could be an important policy intervention. Future studies should focus on how early infant feeding decisions change over time, as well as the health outcomes for mother and child. Keywords: Exclusive breastfeeding, Infant feeding practice, infant formula feeding, HIV-infected peripartum women, South Africa, WHO guideline
- Full Text:
- Date Issued: 2017
Genetic diversity, resistance profile of hiv and risk assessment of mother-to-child transmission in pregnant women on antiretroviral therapy in the Eastern Cape, South Africa
- Authors: Adeniyi, Oladele Vincent
- Date: 2019
- Subjects: Antiretroviral agents , HIV infections -- Treatment -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10353/15120 , vital:40183
- Description: Despite the initiation of life-long ART in HIV-infected pregnant women, the rate and determinants of infant HIV transmission are not known, especially in the poor resource settings of the Eastern Cape, South Africa. Maternal anti-retroviral therapy (ART) is crucial for elimination of mother-to-child transmission (MTCT) of HIV. However, the inevitable risks of emergence of HIV drug resistance poses significant threat to achieving this goal of HIV-free generation and keeping mothers alive. Also, it is unclear if women with high viral load at delivery have acquired clinically relevant mutations, which could confer resistance to the ART, thus, further increasing the risks of motherto-child transmission of HIV-drug resistance strains. In addition to the gaps identified in the prevention of mother-to-child transmission (PMTCT) context, the understanding of regional epidemics is crucial to the broader epidemiological profiling of HIV infections in the country. Despite the rapid influx of foreign nationals to South African and Eastern Cape Province, there has not been any molecular epidemiological studies profiling the HIV diversity in the Eastern Cape.
- Full Text:
- Date Issued: 2019
- Authors: Adeniyi, Oladele Vincent
- Date: 2019
- Subjects: Antiretroviral agents , HIV infections -- Treatment -- South Africa
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10353/15120 , vital:40183
- Description: Despite the initiation of life-long ART in HIV-infected pregnant women, the rate and determinants of infant HIV transmission are not known, especially in the poor resource settings of the Eastern Cape, South Africa. Maternal anti-retroviral therapy (ART) is crucial for elimination of mother-to-child transmission (MTCT) of HIV. However, the inevitable risks of emergence of HIV drug resistance poses significant threat to achieving this goal of HIV-free generation and keeping mothers alive. Also, it is unclear if women with high viral load at delivery have acquired clinically relevant mutations, which could confer resistance to the ART, thus, further increasing the risks of motherto-child transmission of HIV-drug resistance strains. In addition to the gaps identified in the prevention of mother-to-child transmission (PMTCT) context, the understanding of regional epidemics is crucial to the broader epidemiological profiling of HIV infections in the country. Despite the rapid influx of foreign nationals to South African and Eastern Cape Province, there has not been any molecular epidemiological studies profiling the HIV diversity in the Eastern Cape.
- Full Text:
- Date Issued: 2019
Molecular identification and antibacterial properties of an ericoid associated mycorrhizal fungus
- Adeoyo, Olusegun R, Pletschke, Brett I, Dames, Joanna F
- Authors: Adeoyo, Olusegun R , Pletschke, Brett I , Dames, Joanna F
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/440378 , vital:73778 , https://doi.org/10.1186/s12866-019-1555-y
- Description: The quest for novel sources of antibacterial compounds have necessitated the inclusion of ericoid mycorrhizal fungi (ERM) commonly found within the root of ericaceous plants. Agar-well diffusion method was used to detect antibacterial activity and was followed by the microbroth diffusion method [minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC)].
- Full Text:
- Date Issued: 2019
- Authors: Adeoyo, Olusegun R , Pletschke, Brett I , Dames, Joanna F
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/440378 , vital:73778 , https://doi.org/10.1186/s12866-019-1555-y
- Description: The quest for novel sources of antibacterial compounds have necessitated the inclusion of ericoid mycorrhizal fungi (ERM) commonly found within the root of ericaceous plants. Agar-well diffusion method was used to detect antibacterial activity and was followed by the microbroth diffusion method [minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC)].
- Full Text:
- Date Issued: 2019
Adoption and risk of mobile financial services: a case of some selected municipalities in Eastern Cape Province
- Authors: Aderibigbe, Ifeoluwa A.I
- Date: 2019
- Subjects: Mobile commerce Finance
- Language: English
- Type: Thesis , Masters , MCom (Economics)
- Identifier: http://hdl.handle.net/10353/13281 , vital:39630
- Description: The study investigated risk and adoption of mobile financial services among some users in selected municipalities within the Eastern Cape Province, using the theory of reason action, technology acceptance model and the theory of expected utility and risk aversion to explain the variables. Moreover, the explanatory research design and quantitative data collection approach formed the methodology adopted in the study. In addition, a validated semistructured interview questionnaire was used as a research instrument in the study. The multistage, stratify, purposive and convenience sampling techniques were applied to select 6 research sites and 386 research participants for the study. Three research objectives were stated and tested using descriptive, Principal Component Analysis (PCA) to profile the risk and logit regression statistics. The results of statistical analysis show different level of cross tabulation between MFS and education level, all the 6 different locations, individual age range, job type, and average income of individual. Analysis revealed that age and income level of individuals have the highest relationship with the use of MFS. The statistical analysis used was the logistic regression. Pool of effort of all the stake holders in financial services sector should focus on including the low income earners and the technology should be simple enough for the use of the older generation.
- Full Text:
- Date Issued: 2019
- Authors: Aderibigbe, Ifeoluwa A.I
- Date: 2019
- Subjects: Mobile commerce Finance
- Language: English
- Type: Thesis , Masters , MCom (Economics)
- Identifier: http://hdl.handle.net/10353/13281 , vital:39630
- Description: The study investigated risk and adoption of mobile financial services among some users in selected municipalities within the Eastern Cape Province, using the theory of reason action, technology acceptance model and the theory of expected utility and risk aversion to explain the variables. Moreover, the explanatory research design and quantitative data collection approach formed the methodology adopted in the study. In addition, a validated semistructured interview questionnaire was used as a research instrument in the study. The multistage, stratify, purposive and convenience sampling techniques were applied to select 6 research sites and 386 research participants for the study. Three research objectives were stated and tested using descriptive, Principal Component Analysis (PCA) to profile the risk and logit regression statistics. The results of statistical analysis show different level of cross tabulation between MFS and education level, all the 6 different locations, individual age range, job type, and average income of individual. Analysis revealed that age and income level of individuals have the highest relationship with the use of MFS. The statistical analysis used was the logistic regression. Pool of effort of all the stake holders in financial services sector should focus on including the low income earners and the technology should be simple enough for the use of the older generation.
- Full Text:
- Date Issued: 2019
The tropical environment and malaria in southwestern Nigeria, 1861 – 1960
- Authors: Adetiba, Adedamola Seun
- Date: 2019
- Subjects: Diseases and history -- Africa , Diseases and history -- Nigeria , Medical anthropology -- Africa , Medical anthropology -- Nigeria , Malaria -- Social aspects -- Nigeria , Malaria -- Nigeria -- History , Nigeria -- History , Imperialism -- Health aspects , Medicine -- Colonies -- Great Britain -- History
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/76564 , vital:30605
- Description: This thesis is a social history of malaria in southwestern Nigeria. It contributes to the burgeoning literature in the historiography of medicine, specifically the medicine and empire debate. Key to the issues raised in this thesis is the extent to which the limitations in colonial medical policies, most especially malaria control programmes, inspired critical and ingenious responses from African nationalists, doctors, patients, research volunteers, and indigenous medical practitioners. Challenged by a wide range of diseases and a paucity of health facilities and disease control schemes, African rural dwellers became medical pluralists in the ways they imagined and appropriated ideas of Western medicine alongside their indigenous medical practices. Beginning with a detailed historical exploration of the issues that informed the introduction of curative and preventive medicine in southwestern Nigeria, this thesis reveals the focus of colonial medicine. It exposes the one-sided nature of medical services in colonial spaces like southwestern Nigeria and the ways it shaped multifaceted responses from Africans, who were specifically side-lined till the 1950s when the rural medical service scheme was introduced. The focus of colonial medicine is drawn from relatively rich but often subjective historical evidence, such as a plethora of official reports of the department of medical and sanitary services, official correspondences within the colonial government in Lagos and Nigeria, and between the colonial government and the colonial office in the United Kingdom. Details of African responses to medical policies were garnered from newspaper publications and correspondences between the African public and the colonial government in Lagos. They reveal very interesting details of the ways Africans imagined, reimagined, and appropriated malaria control ideas and schemes. The central argument in this thesis is that attempts to control malaria in southwestern Nigeria till the 1950s, were shaped by a single concern to ameliorate the implications of the disease on the colonial state. It argues that this one-sided nature of malaria control programme informed the basis for medical pluralism in most rural spaces where African communities became patrons and sponsors of Western medicine and at the same time custodians of their indigenous medical practices. The series of justifications for the sustenance of these services were reinforced on the basis of the failure of the colonial state to guarantee the health needs of their colonial subjects. The aim of the thesis is to reinforce arguments that portray colonial medicine as a “tool of empire” but goes a bit further to explain the extent to which Africans related to this reality. It states quite categorically that Africans were not docile and silent, but that they acted decisively in ways that suited their varied interests and courses.
- Full Text:
- Date Issued: 2019
- Authors: Adetiba, Adedamola Seun
- Date: 2019
- Subjects: Diseases and history -- Africa , Diseases and history -- Nigeria , Medical anthropology -- Africa , Medical anthropology -- Nigeria , Malaria -- Social aspects -- Nigeria , Malaria -- Nigeria -- History , Nigeria -- History , Imperialism -- Health aspects , Medicine -- Colonies -- Great Britain -- History
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/76564 , vital:30605
- Description: This thesis is a social history of malaria in southwestern Nigeria. It contributes to the burgeoning literature in the historiography of medicine, specifically the medicine and empire debate. Key to the issues raised in this thesis is the extent to which the limitations in colonial medical policies, most especially malaria control programmes, inspired critical and ingenious responses from African nationalists, doctors, patients, research volunteers, and indigenous medical practitioners. Challenged by a wide range of diseases and a paucity of health facilities and disease control schemes, African rural dwellers became medical pluralists in the ways they imagined and appropriated ideas of Western medicine alongside their indigenous medical practices. Beginning with a detailed historical exploration of the issues that informed the introduction of curative and preventive medicine in southwestern Nigeria, this thesis reveals the focus of colonial medicine. It exposes the one-sided nature of medical services in colonial spaces like southwestern Nigeria and the ways it shaped multifaceted responses from Africans, who were specifically side-lined till the 1950s when the rural medical service scheme was introduced. The focus of colonial medicine is drawn from relatively rich but often subjective historical evidence, such as a plethora of official reports of the department of medical and sanitary services, official correspondences within the colonial government in Lagos and Nigeria, and between the colonial government and the colonial office in the United Kingdom. Details of African responses to medical policies were garnered from newspaper publications and correspondences between the African public and the colonial government in Lagos. They reveal very interesting details of the ways Africans imagined, reimagined, and appropriated malaria control ideas and schemes. The central argument in this thesis is that attempts to control malaria in southwestern Nigeria till the 1950s, were shaped by a single concern to ameliorate the implications of the disease on the colonial state. It argues that this one-sided nature of malaria control programme informed the basis for medical pluralism in most rural spaces where African communities became patrons and sponsors of Western medicine and at the same time custodians of their indigenous medical practices. The series of justifications for the sustenance of these services were reinforced on the basis of the failure of the colonial state to guarantee the health needs of their colonial subjects. The aim of the thesis is to reinforce arguments that portray colonial medicine as a “tool of empire” but goes a bit further to explain the extent to which Africans related to this reality. It states quite categorically that Africans were not docile and silent, but that they acted decisively in ways that suited their varied interests and courses.
- Full Text:
- Date Issued: 2019
Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues
- Adeyemi, Christiana M, Hoppe, Heinrich C, Isaacs, Michelle, Klein, Rosalyn, Lobb, Kevin A, Kaye, Perry T
- Authors: Adeyemi, Christiana M , Hoppe, Heinrich C , Isaacs, Michelle , Klein, Rosalyn , Lobb, Kevin A , Kaye, Perry T
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/443238 , vital:74101 , https://doi.org/10.1016/j.tet.2019.02.003
- Description: An efficient synthetic pathway to a series of novel “reverse” fosmidomycin analogues has been developed, commencing from substituted benzylamines. In these analogues, the fosmidomycin hydroxamate moiety is reversed and the tetrahedral methylene carbon adjacent to the phosphonate moiety is replaced by a nitrogen atom bearing different benzyl groups. The resulting phosphonate esters were designed as potential antimalarial “pro-drugs”.
- Full Text:
- Date Issued: 2019
- Authors: Adeyemi, Christiana M , Hoppe, Heinrich C , Isaacs, Michelle , Klein, Rosalyn , Lobb, Kevin A , Kaye, Perry T
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/443238 , vital:74101 , https://doi.org/10.1016/j.tet.2019.02.003
- Description: An efficient synthetic pathway to a series of novel “reverse” fosmidomycin analogues has been developed, commencing from substituted benzylamines. In these analogues, the fosmidomycin hydroxamate moiety is reversed and the tetrahedral methylene carbon adjacent to the phosphonate moiety is replaced by a nitrogen atom bearing different benzyl groups. The resulting phosphonate esters were designed as potential antimalarial “pro-drugs”.
- Full Text:
- Date Issued: 2019
Synthesis of N-Substituted phosphoramidic acid esters as “reverse” fosmidomycin analogues
- Adeyemi, Christiana M, Hoppe, Heinrich C, Isaacs, Michelle, Klein, Rosalyn, Lobb, Kevin A, Kaye, Perry T
- Authors: Adeyemi, Christiana M , Hoppe, Heinrich C , Isaacs, Michelle , Klein, Rosalyn , Lobb, Kevin A , Kaye, Perry T
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/447196 , vital:74591 , xlink:href="https://doi.org/10.1016/j.tet.2019.02.003"
- Description: An efficient synthetic pathway to a series of novel “reverse” fosmidomycin analogues has been developed, commencing from substituted benzylamines. In these analogues, the fosmidomycin hydroxamate moiety is reversed and the tetrahedral methylene carbon adjacent to the phosphonate moiety is replaced by a nitrogen atom bearing different benzyl groups. The resulting phosphonate esters were designed as potential antimalarial “pro-drugs”.
- Full Text:
- Date Issued: 2019
- Authors: Adeyemi, Christiana M , Hoppe, Heinrich C , Isaacs, Michelle , Klein, Rosalyn , Lobb, Kevin A , Kaye, Perry T
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/447196 , vital:74591 , xlink:href="https://doi.org/10.1016/j.tet.2019.02.003"
- Description: An efficient synthetic pathway to a series of novel “reverse” fosmidomycin analogues has been developed, commencing from substituted benzylamines. In these analogues, the fosmidomycin hydroxamate moiety is reversed and the tetrahedral methylene carbon adjacent to the phosphonate moiety is replaced by a nitrogen atom bearing different benzyl groups. The resulting phosphonate esters were designed as potential antimalarial “pro-drugs”.
- Full Text:
- Date Issued: 2019
Prevalence and molecular analysis of multidrug-resistant Acinetobacter baumannii in the extra-hospital environment in Mthatha, South Africa
- Adjei, Anane Yaw, Apalata, Teke, Vasaikar, Sandeep, Okuthe, Grace Emily, Songca, Sandile
- Authors: Adjei, Anane Yaw , Apalata, Teke , Vasaikar, Sandeep , Okuthe, Grace Emily , Songca, Sandile
- Date: 2019
- Subjects: Acinetobacter baumannii , Carbapenemase-encoding genes , Multidrug-resistance , ISAba1 , intI1
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/11260/2409 , vital:41457 , https://doi.org/10.1016/j.bjid.2019.09.004
- Description: The presence of Acinetobacter baumannii outside hospitals remains unclear. This study aimed to determine the prevalence of multidrug-resistance (MDR) A. baumannii in the extra-hospital environment in Mthatha, South Africa and to investigate the frequency of carbapenemase-encoding genes. Material and Methods: From August 2016 to July 2017 a total of 598 abattoir samples and 689 aquatic samples were collected and analyzed presumptively by cultural methods for the presence of A. baumannii using CHROMagarTM Acinetobacter medium. Species identification was performed by autoSCAN-4 (Dade Behring Inc., IL) and confirmed by the detection of their intrinsic blaOXA-51 gene. Confirmed MDR A. baumannii isolates were screened for the presence of carbapenemase-encoding genes, ISAba1 insertion sequence and integrase intI1. Results: In total, 248 (19.3%) Acinetobacter species were isolated. Acinetobacter. baumannii was detected in 183 (73.8%) of which 85 (46.4%) and 98 (53.6%) were recovered from abattoir and aquatic respectively. MDR A. baumannii was detected in 56.5% (48/85) abattoir isolates and 53.1% (52/98) aquatic isolates. Isolates showed high resistance to antimicrobials most frequently used to treat Acinetobacter infections such as piperacillin/tazobactam; abattoir (98% of isolates resistant), aquatic (94% of isolates resistant), ceftazidime (84%, 83%), ciprofloxacin (71%, 70%), amikacin (41%, 42%), imipenem (75%, 73%), and meropenem (74%, 71%). All the isolates were susceptible to tigecycline and colistin. All the isolates carried blaOXA-51-like. The blaOXA-23 was detected in 32 (66.7%) abattoir isolates and 11 (21.2%) aquatic isolates. The blaOXA-58-like was positive in 7 (14.6%) and 4 (7.7%) abattoir and aquatic isolates, respectively. Both groups of isolates lacked blaOXA-24-like, blaIMP-type, blaVIM-type, blaNDM-1, blaSIM, blaAmpC, ISAba1 and inI1. Isolates showed high level of Multiple Antibiotic Resistance Index (MARI) ranging from 0.20-0.52. Conclusion: Extra-hospital sources such as abattoir and aquatic environments may be a vehicle of spread of MDR A. baumannii strains in the community and hospital settings.
- Full Text:
- Date Issued: 2019
- Authors: Adjei, Anane Yaw , Apalata, Teke , Vasaikar, Sandeep , Okuthe, Grace Emily , Songca, Sandile
- Date: 2019
- Subjects: Acinetobacter baumannii , Carbapenemase-encoding genes , Multidrug-resistance , ISAba1 , intI1
- Language: English
- Type: article , text
- Identifier: http://hdl.handle.net/11260/2409 , vital:41457 , https://doi.org/10.1016/j.bjid.2019.09.004
- Description: The presence of Acinetobacter baumannii outside hospitals remains unclear. This study aimed to determine the prevalence of multidrug-resistance (MDR) A. baumannii in the extra-hospital environment in Mthatha, South Africa and to investigate the frequency of carbapenemase-encoding genes. Material and Methods: From August 2016 to July 2017 a total of 598 abattoir samples and 689 aquatic samples were collected and analyzed presumptively by cultural methods for the presence of A. baumannii using CHROMagarTM Acinetobacter medium. Species identification was performed by autoSCAN-4 (Dade Behring Inc., IL) and confirmed by the detection of their intrinsic blaOXA-51 gene. Confirmed MDR A. baumannii isolates were screened for the presence of carbapenemase-encoding genes, ISAba1 insertion sequence and integrase intI1. Results: In total, 248 (19.3%) Acinetobacter species were isolated. Acinetobacter. baumannii was detected in 183 (73.8%) of which 85 (46.4%) and 98 (53.6%) were recovered from abattoir and aquatic respectively. MDR A. baumannii was detected in 56.5% (48/85) abattoir isolates and 53.1% (52/98) aquatic isolates. Isolates showed high resistance to antimicrobials most frequently used to treat Acinetobacter infections such as piperacillin/tazobactam; abattoir (98% of isolates resistant), aquatic (94% of isolates resistant), ceftazidime (84%, 83%), ciprofloxacin (71%, 70%), amikacin (41%, 42%), imipenem (75%, 73%), and meropenem (74%, 71%). All the isolates were susceptible to tigecycline and colistin. All the isolates carried blaOXA-51-like. The blaOXA-23 was detected in 32 (66.7%) abattoir isolates and 11 (21.2%) aquatic isolates. The blaOXA-58-like was positive in 7 (14.6%) and 4 (7.7%) abattoir and aquatic isolates, respectively. Both groups of isolates lacked blaOXA-24-like, blaIMP-type, blaVIM-type, blaNDM-1, blaSIM, blaAmpC, ISAba1 and inI1. Isolates showed high level of Multiple Antibiotic Resistance Index (MARI) ranging from 0.20-0.52. Conclusion: Extra-hospital sources such as abattoir and aquatic environments may be a vehicle of spread of MDR A. baumannii strains in the community and hospital settings.
- Full Text:
- Date Issued: 2019
Investigating the effects of performance appraisal in the department of water and sanitation: a study of southern operations regional office
- Authors: Adonis, Phelisa
- Date: 2019
- Subjects: Employees -- Rating of
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/40226 , vital:35983
- Description: This research examined the use of a personnel performance appraisal, a component of performance management system to evaluate employees at the Southern Operation Region Office of the Department of Water and Sanitation, Port Elizabeth and how this affects their performance. Writers in the available literature, contend that the objective of performance appraisal policy is to review work performance and provide feedback to facilitate measures and programmes to improve employee performance. Cascio and Aginis (2011:73) write that performance appraisal is a systematic description of individual or group job-relevant strengths and weaknesses as an important part of a performance management system. The study firstly analyses the effectiveness of performance appraisal in evaluating the management of the utilisation of resources. Secondly, the appropriateness of the tool in assessing the capacity of employees and contributing towards facilitating programmes and training to develop employee effectiveness. Thirdly, the study also examined the perception of employees on the use of performance appraisal as a management tool in the Department of Water and Sanitation Regional Operation Office. The study adopted a mainly qualitative methodological approach and purposively selected a sample of 30 employees at the Southern Operation Region Office of the Department of Water and Sanitation in Port Elizabeth who completed the questionnaire for the study. The choice of the qualitative research methodology is due to the fact that the approach is well suited to the collection of in-depth and perceptual information and for discovering underlying motivations and perceptions of the employees as respondents. The general employees at the area chosen for the study is one of a relatively young employee profile. The average age of the employees is about 28. The findings revealed that competence, assessment and development, communication and the adequate training which employees received based on the performance appraisal all had an impact on employee performance in Department of Water and Sanitation. Furthermore, factors, such as employee training, competence and communication could not be ignored since they were rated to a moderate extent v by the employees and it also contributed to employee performance. The study findings specifically highlight the importance of effective communication between the employer and the employees in order to improve employee performance appraisal processes. The study recommends a set of guidelines which could be used in improving the current performance appraisal policy and further boost employee performance.
- Full Text:
- Date Issued: 2019
- Authors: Adonis, Phelisa
- Date: 2019
- Subjects: Employees -- Rating of
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/40226 , vital:35983
- Description: This research examined the use of a personnel performance appraisal, a component of performance management system to evaluate employees at the Southern Operation Region Office of the Department of Water and Sanitation, Port Elizabeth and how this affects their performance. Writers in the available literature, contend that the objective of performance appraisal policy is to review work performance and provide feedback to facilitate measures and programmes to improve employee performance. Cascio and Aginis (2011:73) write that performance appraisal is a systematic description of individual or group job-relevant strengths and weaknesses as an important part of a performance management system. The study firstly analyses the effectiveness of performance appraisal in evaluating the management of the utilisation of resources. Secondly, the appropriateness of the tool in assessing the capacity of employees and contributing towards facilitating programmes and training to develop employee effectiveness. Thirdly, the study also examined the perception of employees on the use of performance appraisal as a management tool in the Department of Water and Sanitation Regional Operation Office. The study adopted a mainly qualitative methodological approach and purposively selected a sample of 30 employees at the Southern Operation Region Office of the Department of Water and Sanitation in Port Elizabeth who completed the questionnaire for the study. The choice of the qualitative research methodology is due to the fact that the approach is well suited to the collection of in-depth and perceptual information and for discovering underlying motivations and perceptions of the employees as respondents. The general employees at the area chosen for the study is one of a relatively young employee profile. The average age of the employees is about 28. The findings revealed that competence, assessment and development, communication and the adequate training which employees received based on the performance appraisal all had an impact on employee performance in Department of Water and Sanitation. Furthermore, factors, such as employee training, competence and communication could not be ignored since they were rated to a moderate extent v by the employees and it also contributed to employee performance. The study findings specifically highlight the importance of effective communication between the employer and the employees in order to improve employee performance appraisal processes. The study recommends a set of guidelines which could be used in improving the current performance appraisal policy and further boost employee performance.
- Full Text:
- Date Issued: 2019
Antiplasmodial Activity of the n-Hexane Extract from Pleurotus ostreatus (Jacq. ex. Fr) P. Kumm
- Afieroho, Ozadheoghene E, Siwe-Noundou, Xavier, Onyia, Chiazor P, Festus, Osamuyi H, Chukwu, Elizabeth C, Adedokun, Olutayo M, Isaacs, Michelle, Hoppe, Heinrich C, Krause, Rui W M, Abo, Kio A
- Authors: Afieroho, Ozadheoghene E , Siwe-Noundou, Xavier , Onyia, Chiazor P , Festus, Osamuyi H , Chukwu, Elizabeth C , Adedokun, Olutayo M , Isaacs, Michelle , Hoppe, Heinrich C , Krause, Rui W M , Abo, Kio A
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/194981 , vital:45516 , xlink:href="https://doi.org/10.4274/tjps.18894"
- Description: Objectives: Several mushrooms species have been reported to be nematophagous and antiprotozoan. This study reported the antiplasmodial and cytotoxic properties of the n-hexane extract from the edible mushroom Pleurotus ostreatus and the isolation of a sterol from the extract. Materials and Methods: Antiplasmodial and cytotoxicity assays were done in vitro using the plasmodium lactate dehydrogenase assay and human HeLa cervical cell lines, respectively. The structure of the isolated compound from the n-hexane extract was elucidated using spectroscopic techniques. Results: The n-hexane extract (yield: 0.93% w/w) showed dose dependent antiplasmodial activity with the trend in parasite inhibition of: chloroquine (IC50=0.016 μg/mL) > n-hexane extract (IC50=25.18 μg/mL). It also showed mild cytotoxicity (IC50>100 μg/mL; selectivity index >4) compared to the reference drug emetine (IC50=0.013 μg/mL). The known sterol, ergostan-5,7,22-trien-3-ol, was isolated and characterized from the extract. Conclusion: This study reporting for the first time the antiplasmodial activity of P. ostreatus revealed its nutraceutical potential in the management of malaria.
- Full Text:
- Date Issued: 2019
- Authors: Afieroho, Ozadheoghene E , Siwe-Noundou, Xavier , Onyia, Chiazor P , Festus, Osamuyi H , Chukwu, Elizabeth C , Adedokun, Olutayo M , Isaacs, Michelle , Hoppe, Heinrich C , Krause, Rui W M , Abo, Kio A
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/194981 , vital:45516 , xlink:href="https://doi.org/10.4274/tjps.18894"
- Description: Objectives: Several mushrooms species have been reported to be nematophagous and antiprotozoan. This study reported the antiplasmodial and cytotoxic properties of the n-hexane extract from the edible mushroom Pleurotus ostreatus and the isolation of a sterol from the extract. Materials and Methods: Antiplasmodial and cytotoxicity assays were done in vitro using the plasmodium lactate dehydrogenase assay and human HeLa cervical cell lines, respectively. The structure of the isolated compound from the n-hexane extract was elucidated using spectroscopic techniques. Results: The n-hexane extract (yield: 0.93% w/w) showed dose dependent antiplasmodial activity with the trend in parasite inhibition of: chloroquine (IC50=0.016 μg/mL) > n-hexane extract (IC50=25.18 μg/mL). It also showed mild cytotoxicity (IC50>100 μg/mL; selectivity index >4) compared to the reference drug emetine (IC50=0.013 μg/mL). The known sterol, ergostan-5,7,22-trien-3-ol, was isolated and characterized from the extract. Conclusion: This study reporting for the first time the antiplasmodial activity of P. ostreatus revealed its nutraceutical potential in the management of malaria.
- Full Text:
- Date Issued: 2019
Mainstreaming education for sustainable development: Elaborating the role of position-practice systems using seven laminations of scale
- Agbedahin, Adesuwa V, Lotz-Sisitka, Heila
- Authors: Agbedahin, Adesuwa V , Lotz-Sisitka, Heila
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/182428 , vital:43829 , xlink:href="https://doi.org/10.1080/14767430.2019.1602975"
- Description: The United Nations Sustainable Development Goal 4.7 proposes that Education for Sustainable Development (ESD) should be included at all levels of education, known as ‘mainstreaming’. However, there is little guidance as to how to achieve this. ESD mainstreaming demands more than simply a technical policy transfer; it also requires attention to the position-practice systems of involved agents. This article critically assesses the mainstreaming of ESD in the case of university educators in Africa who have participated in the International Training Programme on ESD in higher education. It clarifies their position-practice systems in terms of Bhaskar’s seven laminations of scale. This article therefore provides a detailed description of the ways in which agents' position-practice systems enable and constrain ESD mainstreaming. It also demonstrates that a critical realist perspective can contribute towards the understanding and achievement of transformation towards sustainability and can help to ensure the flourishing of both current and future generations.
- Full Text:
- Date Issued: 2019
- Authors: Agbedahin, Adesuwa V , Lotz-Sisitka, Heila
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/182428 , vital:43829 , xlink:href="https://doi.org/10.1080/14767430.2019.1602975"
- Description: The United Nations Sustainable Development Goal 4.7 proposes that Education for Sustainable Development (ESD) should be included at all levels of education, known as ‘mainstreaming’. However, there is little guidance as to how to achieve this. ESD mainstreaming demands more than simply a technical policy transfer; it also requires attention to the position-practice systems of involved agents. This article critically assesses the mainstreaming of ESD in the case of university educators in Africa who have participated in the International Training Programme on ESD in higher education. It clarifies their position-practice systems in terms of Bhaskar’s seven laminations of scale. This article therefore provides a detailed description of the ways in which agents' position-practice systems enable and constrain ESD mainstreaming. It also demonstrates that a critical realist perspective can contribute towards the understanding and achievement of transformation towards sustainability and can help to ensure the flourishing of both current and future generations.
- Full Text:
- Date Issued: 2019
Eight decades of invasion by Chromolaena odorata (Asteraceae) and its biological control in West Africa: the story so far
- Aigbedion-Atalor, Pascal O, Adom, Medetissi, Day, Michael D, Uyi, Osariyekemwen O, Egbon, Ikponmwosa N, Idemudia, I, Igbinosa, Igho B, Paterson, Iain D, Braimah, Haruna, Wilson, David D, Zachariades, Costas
- Authors: Aigbedion-Atalor, Pascal O , Adom, Medetissi , Day, Michael D , Uyi, Osariyekemwen O , Egbon, Ikponmwosa N , Idemudia, I , Igbinosa, Igho B , Paterson, Iain D , Braimah, Haruna , Wilson, David D , Zachariades, Costas
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/417450 , vital:71454 , xlink:href="https://doi.org/10.1080/09583157.2019.1670782"
- Description: Chromolaena odorata (L.) R.M. King and H. Robinson (Asteraceae) is a perennial weedy shrub of neotropical origin and a serious biotic threat in its invasive range. The Asian-West Africa (AWA) biotype of C. odorata present in West Africa is both morphologically and genetically different from the southern African (SA) biotype. The AWA biotype was first introduced into Nigeria in the late 1930s and rapidly spread across West Africa. Currently, 12 of the 16 countries in West Africa have been invaded, with significant negative effects on indigenous flora and fauna. However, locals in West Africa have found several uses for the weed. As chemical, physical and other conventional methods were unsustainable, costly and largely ineffective, three biological control agents, Apion brunneonigrum (Coleoptera: Brentidae), Pareuchaetes pseudoinsulata (Lepidoptera: Erebidae) and Cecidochares connexa (Diptera: Tephritidae), have been released in West Africa between the 1970s and the early 2000s. However, only C. connexa and P. pseudoinsulata established, contributing to the control of the weed, in six and four countries in West Africa respectively. Limited research funding, the absence of post-release evaluations of the established agents, and the ‘conflict of interest’ status of C. odorata (i.e. being beneficial for local use but damaging to ecosystem services and agriculture), are serious factors deterring the overall biological control effort. Here, using historical records and field surveys, we examine the invasion history, spread, impacts, and management of C. odorata in West Africa and make recommendations for the sustainable management of C. odorata in the region.
- Full Text:
- Date Issued: 2019
- Authors: Aigbedion-Atalor, Pascal O , Adom, Medetissi , Day, Michael D , Uyi, Osariyekemwen O , Egbon, Ikponmwosa N , Idemudia, I , Igbinosa, Igho B , Paterson, Iain D , Braimah, Haruna , Wilson, David D , Zachariades, Costas
- Date: 2019
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/417450 , vital:71454 , xlink:href="https://doi.org/10.1080/09583157.2019.1670782"
- Description: Chromolaena odorata (L.) R.M. King and H. Robinson (Asteraceae) is a perennial weedy shrub of neotropical origin and a serious biotic threat in its invasive range. The Asian-West Africa (AWA) biotype of C. odorata present in West Africa is both morphologically and genetically different from the southern African (SA) biotype. The AWA biotype was first introduced into Nigeria in the late 1930s and rapidly spread across West Africa. Currently, 12 of the 16 countries in West Africa have been invaded, with significant negative effects on indigenous flora and fauna. However, locals in West Africa have found several uses for the weed. As chemical, physical and other conventional methods were unsustainable, costly and largely ineffective, three biological control agents, Apion brunneonigrum (Coleoptera: Brentidae), Pareuchaetes pseudoinsulata (Lepidoptera: Erebidae) and Cecidochares connexa (Diptera: Tephritidae), have been released in West Africa between the 1970s and the early 2000s. However, only C. connexa and P. pseudoinsulata established, contributing to the control of the weed, in six and four countries in West Africa respectively. Limited research funding, the absence of post-release evaluations of the established agents, and the ‘conflict of interest’ status of C. odorata (i.e. being beneficial for local use but damaging to ecosystem services and agriculture), are serious factors deterring the overall biological control effort. Here, using historical records and field surveys, we examine the invasion history, spread, impacts, and management of C. odorata in West Africa and make recommendations for the sustainable management of C. odorata in the region.
- Full Text:
- Date Issued: 2019