Being moved by a way the world is not
- Authors: Jones, Ward E
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/275631 , vital:55064 , xlink:href="https://doi.org/10.1007/s11229-009-9522-z"
- Description: At the end of Lecture 3 of The Empirical Stance, Bas van Fraassen suggests that we see the change of view involved in scientific revolutions as being, at least in part, emotional. In this paper, I explore one plausible way of cashing out this suggestion. Someone’s emotional approval of a description of the world, I argue, thereby shows that she takes herself to have reason to take that description seriously. This is true even if she is convinced—as a scientific community is when it considers alternative theories—that this description is false, that it is not the way the world is.
- Full Text:
- Date Issued: 2011
- Authors: Jones, Ward E
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/275631 , vital:55064 , xlink:href="https://doi.org/10.1007/s11229-009-9522-z"
- Description: At the end of Lecture 3 of The Empirical Stance, Bas van Fraassen suggests that we see the change of view involved in scientific revolutions as being, at least in part, emotional. In this paper, I explore one plausible way of cashing out this suggestion. Someone’s emotional approval of a description of the world, I argue, thereby shows that she takes herself to have reason to take that description seriously. This is true even if she is convinced—as a scientific community is when it considers alternative theories—that this description is false, that it is not the way the world is.
- Full Text:
- Date Issued: 2011
Wisdom as an aim of higher education
- Authors: Jones, Ward E
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/275765 , vital:55077 , xlink:href="https://doi.org/10.1007/s10790-014-9443-z"
- Description: A central concern of theoretical speculation about education is the kind of epistemic states that education can and should aim to achieve. One such epistemic state, long neglected in both education theory and philosophy, is wisdom. Might wisdom be something that educators should aim for? And might it be something that their students can achieve? My answer will be a qualified yes.
- Full Text:
- Date Issued: 2015
- Authors: Jones, Ward E
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/275765 , vital:55077 , xlink:href="https://doi.org/10.1007/s10790-014-9443-z"
- Description: A central concern of theoretical speculation about education is the kind of epistemic states that education can and should aim to achieve. One such epistemic state, long neglected in both education theory and philosophy, is wisdom. Might wisdom be something that educators should aim for? And might it be something that their students can achieve? My answer will be a qualified yes.
- Full Text:
- Date Issued: 2015
Religiosity and sexual risk-taking behaviour among Black female students attending university
- Authors: Yona, Nombeko
- Date: 2009-02
- Subjects: College students -- Sexual behavior , Women college students , Risk-taking (Psychology)
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10353/25129 , vital:63980
- Description: The degree to which religious identity acts as a protective buffer against sexual risk - taking in late adolescence and young adults was investigated among 100 Black female university students. Allport and Ross’ Religious Orientation Scale was used to examine the relationship among religiosity, sexual activity and condom use. The results indicated that greater intrinsic and extrinsic religiosity were associated with less sexual activity and condom use. Religious identification therefore protected respondents from sexual risk- taking but sexually active students with high levels of intrinsic and extrinsic religiosity were less likely to use condoms. , Thesis (MSoc) -- Faculty of Social Sciences and Humanities, 2009
- Full Text:
- Date Issued: 2009-02
- Authors: Yona, Nombeko
- Date: 2009-02
- Subjects: College students -- Sexual behavior , Women college students , Risk-taking (Psychology)
- Language: English
- Type: text
- Identifier: http://hdl.handle.net/10353/25129 , vital:63980
- Description: The degree to which religious identity acts as a protective buffer against sexual risk - taking in late adolescence and young adults was investigated among 100 Black female university students. Allport and Ross’ Religious Orientation Scale was used to examine the relationship among religiosity, sexual activity and condom use. The results indicated that greater intrinsic and extrinsic religiosity were associated with less sexual activity and condom use. Religious identification therefore protected respondents from sexual risk- taking but sexually active students with high levels of intrinsic and extrinsic religiosity were less likely to use condoms. , Thesis (MSoc) -- Faculty of Social Sciences and Humanities, 2009
- Full Text:
- Date Issued: 2009-02
(Ferrocenylpyrazolyl) zinc (II) benzoates as catalysts for the ring opening polymerization of ε-caprolactone
- Obuah, Collins, Lochee, Yemanlall, Jordaan, Johan H L, Otto, Daniel P, Nyokong, Tebello, Darkwa, James
- Authors: Obuah, Collins , Lochee, Yemanlall , Jordaan, Johan H L , Otto, Daniel P , Nyokong, Tebello , Darkwa, James
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189515 , vital:44853 , xlink:href="https://doi.org/10.1016/j.poly.2015.02.007"
- Description: The reaction of Zn(OAc)2 and C6H5COOH or 3,5-NO2-C6H3COOH with 3-ferrocenylpyrazolyl-methylenepyridine (L1), 3-ferrocenyl-5-methylpyrazolyl-methylenepyridine (L2), 3-ferrocenylpyrazolyl-ethylamine (L3) and 3-ferrocenyl-5-pyrazolyl-ethylamine (L4) afford the corresponding complexes [Zn(C6H5COO)2(L1)] (1), [Zn(C6H5COO)2(L2)] (2), [Zn(3,5-NO2-C6H3COO)2(L1)] (3), [Zn(3,5-NO2-C6H3 COO)2(L2)] (4), [Zn(C6H5COO)2(L3)] (5), [Zn(C6H5COO)2(L4)] (6), [Zn(3,5-NO2-C6H3COO)2(L3)] (7) and [Zn(3,5-NO2-C6H3COO)2(L4)] (8). These complexes behave as catalysts for the ring opening polymerization of e-caprolactone to produce polymers with molecular weight that range from 1480 to 7080 g mol1 and exhibited moderate to broad PDIs. Evidence of these complexes acting as catalysts was obtained from both the polymerization data and kinetic studies. The polymerization data show that variation of the [CL]/[C] from 100 to 800 produced PCL with relatively the same molecular weight indicative of a catalyst behavior. The appearance of induction period in kinetic plots strengthens the fact that these complexes are catalysts rather than initiators. MALDI-TOF MS and 1 H NMR data show di-hydroxy end groups, which support the coordination mechanism rather than insertion mechanism. To understand the broad PDIs obtained for some of the polymer, the electronic properties of the zinc complexes were investigated using cyclic voltammetry. The results show that the zinc complexes containing amine based ligands are highly electrophilic therefore making them unstable, hence the broad PDIs observed for zinc complexes containing amine based ligands. Among the eight complexes investigated, complex 7 is the most active catalyst with kp value of 1.18 107 h1 mol1 at 110 C.
- Full Text:
- Date Issued: 2015
- Authors: Obuah, Collins , Lochee, Yemanlall , Jordaan, Johan H L , Otto, Daniel P , Nyokong, Tebello , Darkwa, James
- Date: 2015
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/189515 , vital:44853 , xlink:href="https://doi.org/10.1016/j.poly.2015.02.007"
- Description: The reaction of Zn(OAc)2 and C6H5COOH or 3,5-NO2-C6H3COOH with 3-ferrocenylpyrazolyl-methylenepyridine (L1), 3-ferrocenyl-5-methylpyrazolyl-methylenepyridine (L2), 3-ferrocenylpyrazolyl-ethylamine (L3) and 3-ferrocenyl-5-pyrazolyl-ethylamine (L4) afford the corresponding complexes [Zn(C6H5COO)2(L1)] (1), [Zn(C6H5COO)2(L2)] (2), [Zn(3,5-NO2-C6H3COO)2(L1)] (3), [Zn(3,5-NO2-C6H3 COO)2(L2)] (4), [Zn(C6H5COO)2(L3)] (5), [Zn(C6H5COO)2(L4)] (6), [Zn(3,5-NO2-C6H3COO)2(L3)] (7) and [Zn(3,5-NO2-C6H3COO)2(L4)] (8). These complexes behave as catalysts for the ring opening polymerization of e-caprolactone to produce polymers with molecular weight that range from 1480 to 7080 g mol1 and exhibited moderate to broad PDIs. Evidence of these complexes acting as catalysts was obtained from both the polymerization data and kinetic studies. The polymerization data show that variation of the [CL]/[C] from 100 to 800 produced PCL with relatively the same molecular weight indicative of a catalyst behavior. The appearance of induction period in kinetic plots strengthens the fact that these complexes are catalysts rather than initiators. MALDI-TOF MS and 1 H NMR data show di-hydroxy end groups, which support the coordination mechanism rather than insertion mechanism. To understand the broad PDIs obtained for some of the polymer, the electronic properties of the zinc complexes were investigated using cyclic voltammetry. The results show that the zinc complexes containing amine based ligands are highly electrophilic therefore making them unstable, hence the broad PDIs observed for zinc complexes containing amine based ligands. Among the eight complexes investigated, complex 7 is the most active catalyst with kp value of 1.18 107 h1 mol1 at 110 C.
- Full Text:
- Date Issued: 2015
Representation of the twentieth century socio-economic and political history of Red Location New Brighton (Port Elizabeth) 1903-1963
- Authors: Maliza, Nokuzola Thozama
- Date: 2012-01
- Subjects: History -- Economic conditions , World politics -- South Africa , Squatter settlements -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/26415 , vital:65306
- Description: This study sets out to recapture the rich history and diverse culture of Red Location, New Brighton. Port Elizabeth. It explains the reasons for the establishment of Red Location in 1903, and goes on to look at the Economic and Social life of the Community. Two chapters are then devoted to political struggles in Red Location and New Brighton, long regarded as one of the most militant African townships in the apartheid era. Finally, we look at the way in which Red Location has been represented in the substantial Red Location Museum project, and the extent to which the Museum reflects the historical reality. , Thesis (MHIS) -- Faculty of Humanities, 2012
- Full Text:
- Date Issued: 2012-01
- Authors: Maliza, Nokuzola Thozama
- Date: 2012-01
- Subjects: History -- Economic conditions , World politics -- South Africa , Squatter settlements -- South Africa
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10353/26415 , vital:65306
- Description: This study sets out to recapture the rich history and diverse culture of Red Location, New Brighton. Port Elizabeth. It explains the reasons for the establishment of Red Location in 1903, and goes on to look at the Economic and Social life of the Community. Two chapters are then devoted to political struggles in Red Location and New Brighton, long regarded as one of the most militant African townships in the apartheid era. Finally, we look at the way in which Red Location has been represented in the substantial Red Location Museum project, and the extent to which the Museum reflects the historical reality. , Thesis (MHIS) -- Faculty of Humanities, 2012
- Full Text:
- Date Issued: 2012-01
Electrocatalytic oxidation of cysteine by molybdenum (V) phthalocyanine complexes
- Mafatle, Tsukutlane J, Nyokong, Tebello
- Authors: Mafatle, Tsukutlane J , Nyokong, Tebello
- Date: 1996
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/293369 , vital:57079 , xlink:href="https://doi.org/10.1016/0022-0728(95)04519-8"
- Description: Chemically modified electrodes, constructed by incorporating oxomolybdenum(V) phthalocyanine (OMo(V)(OH)Pc, Pc = phthalocyanine dianion) into graphite powder were used to catalyse the oxidation of cysteine. Solution catalysis of cysteine by oxomolybdenum(V) tetrasulfophthalocyanine, [OMo(V)(OH)TSPc]4−, was also investigated. A considerable reduction in overpotential for cysteine oxidation was observed. Cysteine oxidation occurred at 0.26 and 0.28 V vs. Ag/vbAgCl for catalysis by Omo(V)(OH)Pc and [OMo(V)(OH)TSPc]4− respectively as opposed to 0.77 V vs. Ag/vbAgCl observed on CoPc chemically modified electrodes. The anodic peak currents vary linearly with cysteine concentration in the range 0.02 to 0.08 mol dm−3 and 0.008 to 0.02 mol dm−3 for [OMo(V)(OH)TSPc]4− and OMo(V)Pc respectively.
- Full Text:
- Date Issued: 1996
- Authors: Mafatle, Tsukutlane J , Nyokong, Tebello
- Date: 1996
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/293369 , vital:57079 , xlink:href="https://doi.org/10.1016/0022-0728(95)04519-8"
- Description: Chemically modified electrodes, constructed by incorporating oxomolybdenum(V) phthalocyanine (OMo(V)(OH)Pc, Pc = phthalocyanine dianion) into graphite powder were used to catalyse the oxidation of cysteine. Solution catalysis of cysteine by oxomolybdenum(V) tetrasulfophthalocyanine, [OMo(V)(OH)TSPc]4−, was also investigated. A considerable reduction in overpotential for cysteine oxidation was observed. Cysteine oxidation occurred at 0.26 and 0.28 V vs. Ag/vbAgCl for catalysis by Omo(V)(OH)Pc and [OMo(V)(OH)TSPc]4− respectively as opposed to 0.77 V vs. Ag/vbAgCl observed on CoPc chemically modified electrodes. The anodic peak currents vary linearly with cysteine concentration in the range 0.02 to 0.08 mol dm−3 and 0.008 to 0.02 mol dm−3 for [OMo(V)(OH)TSPc]4− and OMo(V)Pc respectively.
- Full Text:
- Date Issued: 1996
The role of local economic development in poverty alleviation: a case of Buffalo City Metropolitan Municipality
- Authors: Mkanyeli, Vuyokazi
- Date: 2021-04
- Subjects: Economic development -- South Africa -- Buffalo City , Poverty -- Economic aspects -- South Africa -- Buffalo City
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/53478 , vital:45157
- Description: The primary purpose of Local Economic Development is centred on the improvement of the quality of life for all. Thus, LED plays a fundamental role in poverty alleviation in communities, if utilised effectively and efficiently. The present study was conducted in Buffalo City Metropolitan Municipality, which is located in the Eastern Cape Province of South Africa. The chosen case study is characterised by high unemployment and poverty. Thus, this study explored the role of LED strategies in alleviating poverty within the municipality. The study adopted a qualitative research methodology with the use of a case study research design. Data was collected through interviews with LED officials within the municipality and analysed through thematic analysis. The study findings showed that in as much as the BCMM is characterised by poverty, it strives to alleviate poverty through employing various LED strategies such as agriculture, tourism, Small, Medium and Micro Enterprises, and the Metro Growth and Development Strategy. The findings also revealed that the municipality is confronted with a myriad of challenges that hinder effective implementation of these strategies. If the strategies are effectively implemented, the study participants argued that it will result in job creation, income generation and skills development. The challenges include limited resources, lack of investments, lack of skilled personnel and lack of connectivity. The study recommends infrastructure development, establishment of mechanisms to attract investments and focusing more on building capabilities. The municipality should also implement more LED strategies as well as engage in more partnerships. This will ensure poverty alleviation within the Buffalo City Metropolitan Municipality. , Thesis (MPA) -- Faculty of Humanities, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Mkanyeli, Vuyokazi
- Date: 2021-04
- Subjects: Economic development -- South Africa -- Buffalo City , Poverty -- Economic aspects -- South Africa -- Buffalo City
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/53478 , vital:45157
- Description: The primary purpose of Local Economic Development is centred on the improvement of the quality of life for all. Thus, LED plays a fundamental role in poverty alleviation in communities, if utilised effectively and efficiently. The present study was conducted in Buffalo City Metropolitan Municipality, which is located in the Eastern Cape Province of South Africa. The chosen case study is characterised by high unemployment and poverty. Thus, this study explored the role of LED strategies in alleviating poverty within the municipality. The study adopted a qualitative research methodology with the use of a case study research design. Data was collected through interviews with LED officials within the municipality and analysed through thematic analysis. The study findings showed that in as much as the BCMM is characterised by poverty, it strives to alleviate poverty through employing various LED strategies such as agriculture, tourism, Small, Medium and Micro Enterprises, and the Metro Growth and Development Strategy. The findings also revealed that the municipality is confronted with a myriad of challenges that hinder effective implementation of these strategies. If the strategies are effectively implemented, the study participants argued that it will result in job creation, income generation and skills development. The challenges include limited resources, lack of investments, lack of skilled personnel and lack of connectivity. The study recommends infrastructure development, establishment of mechanisms to attract investments and focusing more on building capabilities. The municipality should also implement more LED strategies as well as engage in more partnerships. This will ensure poverty alleviation within the Buffalo City Metropolitan Municipality. , Thesis (MPA) -- Faculty of Humanities, 2021
- Full Text:
- Date Issued: 2021-04
Fuel wood use in South Africa: Where to in the 21st Century?
- Williams, Anthony, Shackleton, Charlie M
- Authors: Williams, Anthony , Shackleton, Charlie M
- Date: 2002
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/183026 , vital:43905 , xlink:href="https://doi.org/10.1080/20702620.2002.10434611"
- Description: South Africa is well known for the dichotomous nature of its economy, with its juxtaposed first and third world characteristics, perhaps nowhere more starkly evident than in the energy sector. South Africa produces and consumes over 60% of the total electrical energy on the African continent, and is ranked twelfth in the world in terms of carbon emissions (EIA, 2002). Yet the majority of the South African population does not have access to electricity, and despite the enormous strides taken since 1994 to increase household access to electricity (NER, 2001), newly electrified households, more often than not, cannot afford the appliances nor the monthly costs required to significantly improve their quality of life (White et al., 1997). Thus, most rural and many peri-urban households continue to use fuelwood as their primary energy source (Griffin et al., 1992; Dyer, 1996; Kotze, 1996; Williams et al., 1996). Fuelwood use presents both opportunities and risks.
- Full Text:
- Date Issued: 2002
- Authors: Williams, Anthony , Shackleton, Charlie M
- Date: 2002
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/183026 , vital:43905 , xlink:href="https://doi.org/10.1080/20702620.2002.10434611"
- Description: South Africa is well known for the dichotomous nature of its economy, with its juxtaposed first and third world characteristics, perhaps nowhere more starkly evident than in the energy sector. South Africa produces and consumes over 60% of the total electrical energy on the African continent, and is ranked twelfth in the world in terms of carbon emissions (EIA, 2002). Yet the majority of the South African population does not have access to electricity, and despite the enormous strides taken since 1994 to increase household access to electricity (NER, 2001), newly electrified households, more often than not, cannot afford the appliances nor the monthly costs required to significantly improve their quality of life (White et al., 1997). Thus, most rural and many peri-urban households continue to use fuelwood as their primary energy source (Griffin et al., 1992; Dyer, 1996; Kotze, 1996; Williams et al., 1996). Fuelwood use presents both opportunities and risks.
- Full Text:
- Date Issued: 2002
Perceptions of mental illness among the residents of the Eastern Cape Province in South Africa: The influence of culture and religion on their coping strategies.: subtitle if needed. If no subtitle follow instructions in manual
- Authors: Sikrweqe, Odwa
- Date: 2023-04
- Subjects: Mental illness , Mental illness--Religious aspects , Mental illness-- Culture aspects
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60445 , vital:65507
- Description: Mental illness has become a global concern, with consequences that may result in a mental health pandemic. Studies conducted on mental illness suggest that religious and cultural beliefs not only affect the expression of mental illness, but also the diagnosis and treatment of mental conditions. South Africa is a country imbued with cultural and religious diversity, which creates different groupings of people, holding diverse beliefs regarding mental illness. In many contexts, supernatural beliefs, traditional healing and indigenous medicines and treatments are considered in the treatment of the symptoms associated with mental illnesses, especially on contexts where there is a reliance on religio-cultural beliefs. Even though there has been a significant increase in the contribution to research focusing on mental health in diverse contexts, much of this research has focused on subjective experiences. Little to no information is available on population-based studies in South Africa regarding mental illness in diverse contexts, thus limiting the generalisation of findings related to cultural and religious influences on mental illness. This dearth of information further limits the development of psychological interventions. The study aimed to explore how mental illness is perceived by the participants and thereafter explored the influence of culture and religion in coping with mental illness by the residents of the Eastern Cape. The study was quantitative in nature and adopted an exploratory-descriptive design. The researcher made use of a questionnaire as a research tool and QuestionPro was utilized as a platform. A convenience sampling technique was utilised. In ensuring rigour of the study, the researcher ensured maximal validity (accurate representation of the data) and reliability (ability to repeat the research procedure). Ethical principles have been adhered to as per the principles on the Belmont Report, to ensure safety of the participants and this includes anonymity, confidentiality and the right to withdraw from participation in the study. Data has been analysed using descriptive and inferential statistics. A sample size of 101 participants from the general population of residents of the Eastern Cape completed the online survey. The results of the study revealed that the residents of the Eastern Cape have substantial knowledge pertaining the cause of mental illness and indicated both positive and negative attitudes towards the mentally ill and possess coping strategies to deal with a mental illness. In addition, the results show that there is a relation between religion/culture and coping with a mental illness by the participants of the study. The findings of this study emphasize the necessity of public education efforts that understand and respect people's cultural diversity, as well as teamwork among traditional and medical professionals. Future studies should focus on the use of discourse analysis to better investigate indigenous groups' conceptions of mental illness and their views about its aetiology and treatment. , Thesis (MA) -- Faculty of Health Sciences, School of Behavioural Science, 2023
- Full Text:
- Date Issued: 2023-04
- Authors: Sikrweqe, Odwa
- Date: 2023-04
- Subjects: Mental illness , Mental illness--Religious aspects , Mental illness-- Culture aspects
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/60445 , vital:65507
- Description: Mental illness has become a global concern, with consequences that may result in a mental health pandemic. Studies conducted on mental illness suggest that religious and cultural beliefs not only affect the expression of mental illness, but also the diagnosis and treatment of mental conditions. South Africa is a country imbued with cultural and religious diversity, which creates different groupings of people, holding diverse beliefs regarding mental illness. In many contexts, supernatural beliefs, traditional healing and indigenous medicines and treatments are considered in the treatment of the symptoms associated with mental illnesses, especially on contexts where there is a reliance on religio-cultural beliefs. Even though there has been a significant increase in the contribution to research focusing on mental health in diverse contexts, much of this research has focused on subjective experiences. Little to no information is available on population-based studies in South Africa regarding mental illness in diverse contexts, thus limiting the generalisation of findings related to cultural and religious influences on mental illness. This dearth of information further limits the development of psychological interventions. The study aimed to explore how mental illness is perceived by the participants and thereafter explored the influence of culture and religion in coping with mental illness by the residents of the Eastern Cape. The study was quantitative in nature and adopted an exploratory-descriptive design. The researcher made use of a questionnaire as a research tool and QuestionPro was utilized as a platform. A convenience sampling technique was utilised. In ensuring rigour of the study, the researcher ensured maximal validity (accurate representation of the data) and reliability (ability to repeat the research procedure). Ethical principles have been adhered to as per the principles on the Belmont Report, to ensure safety of the participants and this includes anonymity, confidentiality and the right to withdraw from participation in the study. Data has been analysed using descriptive and inferential statistics. A sample size of 101 participants from the general population of residents of the Eastern Cape completed the online survey. The results of the study revealed that the residents of the Eastern Cape have substantial knowledge pertaining the cause of mental illness and indicated both positive and negative attitudes towards the mentally ill and possess coping strategies to deal with a mental illness. In addition, the results show that there is a relation between religion/culture and coping with a mental illness by the participants of the study. The findings of this study emphasize the necessity of public education efforts that understand and respect people's cultural diversity, as well as teamwork among traditional and medical professionals. Future studies should focus on the use of discourse analysis to better investigate indigenous groups' conceptions of mental illness and their views about its aetiology and treatment. , Thesis (MA) -- Faculty of Health Sciences, School of Behavioural Science, 2023
- Full Text:
- Date Issued: 2023-04
Computational analysis of known drug resistant mutants of Plasmodium falciparum Dihydrofolate Reductase (PfDHFR) and screening for novel antifolates against the enzyme
- Authors: Tata, Rolland Bantar
- Date: 2022-04-08
- Subjects: Uncatalogued
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/234184 , vital:50170
- Description: Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2022
- Full Text:
- Date Issued: 2022-04-08
- Authors: Tata, Rolland Bantar
- Date: 2022-04-08
- Subjects: Uncatalogued
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/234184 , vital:50170
- Description: Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2022
- Full Text:
- Date Issued: 2022-04-08
Effect of doping vs covalent linking of a low symmetry zinc phthalocyanine to silica nanoparticles on singlet oxygen production
- Peteni, Siwaphiwe, Nyokong, Tebello
- Authors: Peteni, Siwaphiwe , Nyokong, Tebello
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/187873 , vital:44705 , xlink:href="https://doi.org/10.1016/j.ica.2018.06.029"
- Description: Tris[(4-(pyridin-4-ylthio)-2-thio-4-methylthiazol-5-yl)acetic acid phthalocyaninato] zinc (II) (3) was covalently linked to and doped onto SiNPs. An increase in triplet quantum yields for 3-SiNPs (linked) with decreasing lifetimes was observed. For 3-SiNPs (doped) there was a decrease in both the triplet quantum yield and lifetimes when compared to 3 alone. There was an increase in singlet oxygen quantum yields for 3-SiNPs (linked) compared to 3 from 0.67 to 0.80, while there was a decrease for 3-SiNPs (doped) to 0.25.
- Full Text:
- Date Issued: 2018
- Authors: Peteni, Siwaphiwe , Nyokong, Tebello
- Date: 2018
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/187873 , vital:44705 , xlink:href="https://doi.org/10.1016/j.ica.2018.06.029"
- Description: Tris[(4-(pyridin-4-ylthio)-2-thio-4-methylthiazol-5-yl)acetic acid phthalocyaninato] zinc (II) (3) was covalently linked to and doped onto SiNPs. An increase in triplet quantum yields for 3-SiNPs (linked) with decreasing lifetimes was observed. For 3-SiNPs (doped) there was a decrease in both the triplet quantum yield and lifetimes when compared to 3 alone. There was an increase in singlet oxygen quantum yields for 3-SiNPs (linked) compared to 3 from 0.67 to 0.80, while there was a decrease for 3-SiNPs (doped) to 0.25.
- Full Text:
- Date Issued: 2018
Effectiveness of private land conservation areas in maintaining natural land cover and biodiversity intactness
- Shumba, Tafadzwa, de Vos, Alta, Biggs, Reinette, Esler, Karen J, Ament, Judith M, Clements, Hayley S
- Authors: Shumba, Tafadzwa , de Vos, Alta , Biggs, Reinette , Esler, Karen J , Ament, Judith M , Clements, Hayley S
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/415852 , vital:71294 , xlink:href="https://doi.org/10.1016/j.gecco.2020.e00935"
- Description: Private land conservation areas (PLCAs) are increasingly looked to for meeting the deficit left by state-owned protected areas in reaching global conservation targets. However, despite the increasing extent and recognition of PLCAs as a complementary conservation strategy, little research has been done to quantify their effectiveness; a critical consideration if they are to be counted towards international biodiversity conservation targets. The long history of PLCAs in South Africa provides an interesting case study to address this knowledge gap. Here, we quantified the effectiveness of South African PLCAs by comparing losses in natural land cover and biodiversity intactness within PLCAs with different levels of protection to that of unprotected control points. Points within PLCAs were matched with unprotected control points to test the prediction that if PLCAs offer effective protection, losses in natural land cover and biodiversity intactness would be significantly lower within their boundaries in comparison to unprotected controls exposed to similar conditions. Consequences of natural land cover loss on biodiversity intactness were thus assessed, thus advancing standard approaches for quantifying effectiveness.
- Full Text:
- Date Issued: 2020
- Authors: Shumba, Tafadzwa , de Vos, Alta , Biggs, Reinette , Esler, Karen J , Ament, Judith M , Clements, Hayley S
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/415852 , vital:71294 , xlink:href="https://doi.org/10.1016/j.gecco.2020.e00935"
- Description: Private land conservation areas (PLCAs) are increasingly looked to for meeting the deficit left by state-owned protected areas in reaching global conservation targets. However, despite the increasing extent and recognition of PLCAs as a complementary conservation strategy, little research has been done to quantify their effectiveness; a critical consideration if they are to be counted towards international biodiversity conservation targets. The long history of PLCAs in South Africa provides an interesting case study to address this knowledge gap. Here, we quantified the effectiveness of South African PLCAs by comparing losses in natural land cover and biodiversity intactness within PLCAs with different levels of protection to that of unprotected control points. Points within PLCAs were matched with unprotected control points to test the prediction that if PLCAs offer effective protection, losses in natural land cover and biodiversity intactness would be significantly lower within their boundaries in comparison to unprotected controls exposed to similar conditions. Consequences of natural land cover loss on biodiversity intactness were thus assessed, thus advancing standard approaches for quantifying effectiveness.
- Full Text:
- Date Issued: 2020
Anti-cancer and anti-trypanosomal properties of alkaloids from the root bark of Zanthoxylum leprieurii Guill and Perr
- Eze, Fabian I, Siwe-Noundou, Xavier, Isaacs, Michelle, Patala, Srivinas, Osadebe, Patience O, Krause, Rui W M
- Authors: Eze, Fabian I , Siwe-Noundou, Xavier , Isaacs, Michelle , Patala, Srivinas , Osadebe, Patience O , Krause, Rui W M
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/193352 , vital:45324 , xlink:href="http://dx.doi.org/10.4314/tjpr.v19i11.19"
- Description: Purpose: To isolate the anti-cancer and anti-trypanosomal principles of Zanthoxylum leprieurii, a medicinally versatile wild tropical plant used for managing tumours, African trypanosomiasis, and inflammation in southeastern Nigeria. Methods: The pure compounds were isolated using chromatographic methods. The structural elucidation of the pure compounds was based on their NMR (1D and 2D) and mass spectral data as well as chemical test results. Structure-activity relationships were based on the structural differences among the compounds. The cytotoxicity of the extracts and compounds (1, 2, 3, and 4) was evaluated in HeLa (human cervix adenocarcinoma) cell line while the trypanocidal activities were evaluated on Trypanosoma brucei brucei. Results: Two acridone alkaloids, 1-hydroxy-3-methoxy-10-methylacridin-9 (10H)-one, named fabiocinine (1), and 1-hydroxy-2,3-dimethoxy-10-methylacridin-9 (10H)-one (arborinine, 2), together with a furoquinoline alkaloid, skimmianine (3), and a chelerythrine derivative, 6-acetonyl-5,6-dihydrochelerythrine (4) were isolated from the root bark of Zanthoxylum leprieurii. Skimmianine (3) exhibited cytotoxicity and anti-trypanosomal IC50 of 12.8 and 13.2 µg/mL respectively (p less than 0.05). Compound (1) and arborinine (2) were selectively cytotoxic to HeLa cells with cytotoxicity IC50 of 28.49 and 62.71 µg/mL, respectively, while (4) did not show significant activity (p less than 0.05). Conclusion: Zanthoxylum leprieurii root bark contains cytotoxic and trypanocidal compounds, and is thus a potential source of anti-cancer and anti-trypanosomal leads.
- Full Text:
- Date Issued: 2020
- Authors: Eze, Fabian I , Siwe-Noundou, Xavier , Isaacs, Michelle , Patala, Srivinas , Osadebe, Patience O , Krause, Rui W M
- Date: 2020
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/193352 , vital:45324 , xlink:href="http://dx.doi.org/10.4314/tjpr.v19i11.19"
- Description: Purpose: To isolate the anti-cancer and anti-trypanosomal principles of Zanthoxylum leprieurii, a medicinally versatile wild tropical plant used for managing tumours, African trypanosomiasis, and inflammation in southeastern Nigeria. Methods: The pure compounds were isolated using chromatographic methods. The structural elucidation of the pure compounds was based on their NMR (1D and 2D) and mass spectral data as well as chemical test results. Structure-activity relationships were based on the structural differences among the compounds. The cytotoxicity of the extracts and compounds (1, 2, 3, and 4) was evaluated in HeLa (human cervix adenocarcinoma) cell line while the trypanocidal activities were evaluated on Trypanosoma brucei brucei. Results: Two acridone alkaloids, 1-hydroxy-3-methoxy-10-methylacridin-9 (10H)-one, named fabiocinine (1), and 1-hydroxy-2,3-dimethoxy-10-methylacridin-9 (10H)-one (arborinine, 2), together with a furoquinoline alkaloid, skimmianine (3), and a chelerythrine derivative, 6-acetonyl-5,6-dihydrochelerythrine (4) were isolated from the root bark of Zanthoxylum leprieurii. Skimmianine (3) exhibited cytotoxicity and anti-trypanosomal IC50 of 12.8 and 13.2 µg/mL respectively (p less than 0.05). Compound (1) and arborinine (2) were selectively cytotoxic to HeLa cells with cytotoxicity IC50 of 28.49 and 62.71 µg/mL, respectively, while (4) did not show significant activity (p less than 0.05). Conclusion: Zanthoxylum leprieurii root bark contains cytotoxic and trypanocidal compounds, and is thus a potential source of anti-cancer and anti-trypanosomal leads.
- Full Text:
- Date Issued: 2020
Identification of novel compounds against Plasmodium falciparum Cytochrome bc1 Complex inhibiting the trans-membrane electron transfer pathway: an In Silico study
- Authors: Chebon, Lorna Jemosop
- Date: 2022-10-14
- Subjects: Malaria , Plasmodium falciparum , Molecular dynamics , Antimalarials , Molecules Models , Docking , Cytochromes , Drug resistance , Computer simulation , Drugs Computer-aided design , System analysis
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/365666 , vital:65774 , DOI https://doi.org/10.21504/10962/365666
- Description: Malaria continues to be a burden globally with a myriad of challenges deterring eradication efforts. With most antimalarials facing drug resistance, such as atovaquone (ATQ), alternative compounds that can withstand resistance are warranted. The Plasmodium falciparum cytochrome b (PfCytb), a subunit of P. falciparum cytochrome bc1 complex, is a validated drug target. Structurally, cytochrome b, cytochrome c1, and iron sulphur protein (ISP) subunits form the catalytic domain of the protein complex having heme bL, heme bH and iron-sulphur [2FE-2S] cluster cofactors. These cofactos have redox centres to aid in the electron transfer (ET) process. These subunits promote ET mainly through the enzyme’s ubiquinol oxidation (Qo) and ubiquinone reduction (Qi) processes in the catalytic domain. ATQ drug has been used in the prevention and treatment of uncomplicated malaria by targeting PfCytb protein. Once the mitochondrial transmembrane ET pathway is inhibited, it causes a collapse in its membrane potential. Previously reported ATQ drug resistance has been associated with the point mutations Y268C, Y268N and Y268S. Thus, in finding alternatives to the ATQ drug, this research aimed to: i) employ in silico approaches incorporating protein into phospholipid bilayer for the first time to understand the parasites’ resistance mechanism; ii) determine any sequence and structural differences that could be explored in drug design studies; and iii) screen for PfCytb-iron sulphur protein (Cytb-ISP) hit compounds from South African natural compound database (SANCDB) and Medicines for Malaria Venture (MMV) that can withstand the identified mutations. Using computational tools, comparative sequence and structural analyses were performed on the cytochrome b protein, where the ultimate focus was on P. falciparum cytochrome b and its human homolog. Through multiple sequence alignment, motif discovery and phylogeny, differences between P. falciparum and H. sapiens cytochrome b were identified. Protein modelling of both P. falciparum and H. sapiens cytochrome b - iron sulphur protein (PfCytb-ISP and HsCytb-ISP) was performed. Results showed that at the sequence level, there were few amino acid residue differences because the protein is highly conserved. Important to note is the four-residue deletion in Plasmodium spp. absent in the human homolog. Motif analysis discovered five unique motifs in P. falciparum cytochrome b protein which were mapped onto the predicted protein model. These motifs were not in regions of functional importance; hence their function is still unknown. At a structural level, the four-residue deletion was observed to alter the Qo substrate binding pocket as reported in previous studies and confirmed in this study. This deletion resulted in a 0.83 Å structural displacement. Also, there are currently no in silico studies that have performed experiments with P. falciparum cytochrome b protein incorporated into a phospholipid bilayer. Using 350 ns molecular dynamics (MD) simulations of the holo and ATQ-bound systems, the study highlighted the resistance mechanism of the parasite protein where the loss of active site residue-residue interactions was identified, all linked to the three mutations. The identified compromised interactions are likely to destabilise the protein’s function, specifically in the Qo substrate binding site. This showed the possible effect of mutations on ATQ drug activity, where all three mutations were reported to share a similar resistance mechanism. Thereafter, this research work utilised in silico approaches where both Qo active site and interface pocket were targeted by screening the South African natural compounds database (SANCDB) and Medicines for Malaria Venture (MMV) compounds to identify novel selective hits. SANCDB compounds are known for their structural complexity that preserves the potency of the drug molecule. Both SANCDB and MMV compounds have not been explored as inhibitors against the PfCytb drug target. Molecular docking, molecular dynamics (MD) simulations, principal component, and dynamic residue network (DRN; global and local) analyses were utilised to identify and confirm the potential selective inhibitors. Docking results identified compounds that bound selectively onto PfCytb-ISP with a binding energy ≤ -8.7 kcal/mol-1. Further, this work validated a total of eight potential selective compounds to inhibit PfCytb-ISP protein (Qo active site) not only in the wild-type but also in the presence of the point mutations Y268C, Y268N and Y268S. The selective binding of these hit compounds could be linked to the differences reported at sequence/residue level in chapter 3. DRN and residue contact map analyses of the eight compounds in holo and ligand-bound systems revealed reduced residue interactions and decreased protein communication. This suggests that the eight compounds show the possibility of inhibiting the parasite and disrupting important residue-residue interactions. Additionally, 13 selective compounds were identified to bind at the protein’s heterodimer interface, where global and local analysis confirmed their effect on active site residues (distal location) as well as on the communication network. Based on the sequence differences between PfCytb and the human homolog, these findings suggest these selective compounds as potential allosteric modulators of the parasite enzyme, which may serve as possible replacements of the already resistant ATQ drug. Therefore, these findings pave the way for further in vitro studies to establish their anti-plasmodial inhibition levels. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2022
- Full Text:
- Date Issued: 2022-10-14
- Authors: Chebon, Lorna Jemosop
- Date: 2022-10-14
- Subjects: Malaria , Plasmodium falciparum , Molecular dynamics , Antimalarials , Molecules Models , Docking , Cytochromes , Drug resistance , Computer simulation , Drugs Computer-aided design , System analysis
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/365666 , vital:65774 , DOI https://doi.org/10.21504/10962/365666
- Description: Malaria continues to be a burden globally with a myriad of challenges deterring eradication efforts. With most antimalarials facing drug resistance, such as atovaquone (ATQ), alternative compounds that can withstand resistance are warranted. The Plasmodium falciparum cytochrome b (PfCytb), a subunit of P. falciparum cytochrome bc1 complex, is a validated drug target. Structurally, cytochrome b, cytochrome c1, and iron sulphur protein (ISP) subunits form the catalytic domain of the protein complex having heme bL, heme bH and iron-sulphur [2FE-2S] cluster cofactors. These cofactos have redox centres to aid in the electron transfer (ET) process. These subunits promote ET mainly through the enzyme’s ubiquinol oxidation (Qo) and ubiquinone reduction (Qi) processes in the catalytic domain. ATQ drug has been used in the prevention and treatment of uncomplicated malaria by targeting PfCytb protein. Once the mitochondrial transmembrane ET pathway is inhibited, it causes a collapse in its membrane potential. Previously reported ATQ drug resistance has been associated with the point mutations Y268C, Y268N and Y268S. Thus, in finding alternatives to the ATQ drug, this research aimed to: i) employ in silico approaches incorporating protein into phospholipid bilayer for the first time to understand the parasites’ resistance mechanism; ii) determine any sequence and structural differences that could be explored in drug design studies; and iii) screen for PfCytb-iron sulphur protein (Cytb-ISP) hit compounds from South African natural compound database (SANCDB) and Medicines for Malaria Venture (MMV) that can withstand the identified mutations. Using computational tools, comparative sequence and structural analyses were performed on the cytochrome b protein, where the ultimate focus was on P. falciparum cytochrome b and its human homolog. Through multiple sequence alignment, motif discovery and phylogeny, differences between P. falciparum and H. sapiens cytochrome b were identified. Protein modelling of both P. falciparum and H. sapiens cytochrome b - iron sulphur protein (PfCytb-ISP and HsCytb-ISP) was performed. Results showed that at the sequence level, there were few amino acid residue differences because the protein is highly conserved. Important to note is the four-residue deletion in Plasmodium spp. absent in the human homolog. Motif analysis discovered five unique motifs in P. falciparum cytochrome b protein which were mapped onto the predicted protein model. These motifs were not in regions of functional importance; hence their function is still unknown. At a structural level, the four-residue deletion was observed to alter the Qo substrate binding pocket as reported in previous studies and confirmed in this study. This deletion resulted in a 0.83 Å structural displacement. Also, there are currently no in silico studies that have performed experiments with P. falciparum cytochrome b protein incorporated into a phospholipid bilayer. Using 350 ns molecular dynamics (MD) simulations of the holo and ATQ-bound systems, the study highlighted the resistance mechanism of the parasite protein where the loss of active site residue-residue interactions was identified, all linked to the three mutations. The identified compromised interactions are likely to destabilise the protein’s function, specifically in the Qo substrate binding site. This showed the possible effect of mutations on ATQ drug activity, where all three mutations were reported to share a similar resistance mechanism. Thereafter, this research work utilised in silico approaches where both Qo active site and interface pocket were targeted by screening the South African natural compounds database (SANCDB) and Medicines for Malaria Venture (MMV) compounds to identify novel selective hits. SANCDB compounds are known for their structural complexity that preserves the potency of the drug molecule. Both SANCDB and MMV compounds have not been explored as inhibitors against the PfCytb drug target. Molecular docking, molecular dynamics (MD) simulations, principal component, and dynamic residue network (DRN; global and local) analyses were utilised to identify and confirm the potential selective inhibitors. Docking results identified compounds that bound selectively onto PfCytb-ISP with a binding energy ≤ -8.7 kcal/mol-1. Further, this work validated a total of eight potential selective compounds to inhibit PfCytb-ISP protein (Qo active site) not only in the wild-type but also in the presence of the point mutations Y268C, Y268N and Y268S. The selective binding of these hit compounds could be linked to the differences reported at sequence/residue level in chapter 3. DRN and residue contact map analyses of the eight compounds in holo and ligand-bound systems revealed reduced residue interactions and decreased protein communication. This suggests that the eight compounds show the possibility of inhibiting the parasite and disrupting important residue-residue interactions. Additionally, 13 selective compounds were identified to bind at the protein’s heterodimer interface, where global and local analysis confirmed their effect on active site residues (distal location) as well as on the communication network. Based on the sequence differences between PfCytb and the human homolog, these findings suggest these selective compounds as potential allosteric modulators of the parasite enzyme, which may serve as possible replacements of the already resistant ATQ drug. Therefore, these findings pave the way for further in vitro studies to establish their anti-plasmodial inhibition levels. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2022
- Full Text:
- Date Issued: 2022-10-14
The macroeconomic impact of ocean economy financing in South Africa
- Authors: Matekenya, Weliswa
- Date: 2022-12
- Subjects: Macroeconomics , Maritime –- South Africa
- Language: English
- Type: Doctoral's theses , Thesis
- Identifier: http://hdl.handle.net/10948/60305 , vital:64343
- Description: The global ocean is responsible for providing seafood and employment to the world’s population and is the key driver of global gross domestic product. The ocean economy (blue economy) has been identified as key to unlocking the growth potential of many economies. It is in this context that both the South African government and the private sector have invested in the ocean economy with the purpose of sustaining it and making it more productive. To this end, the government established the Operation Phakisa programme which is meant to fast-track ocean economy development. In line with operation Phakisa imperatives, the South African government began a series of budget allocations towards the various sectors of the oceans economy. This flow of public funds towards oceans economy sectors was with a view to reduce unemployment, grow the economy, increase trade as well as boost entrepreneurship. It is for this reason that the financing of the ocean economy needs to be assessed in terms of its role in ensuring sustainable economic growth through ocean economy activities. While the ocean economy is becoming a new focal point in the discourse on growth and sustainable development both globally and locally, it remains faced with a series of challenges in South Africa. These include inadequate economic incentives, outdated infrastructure, ineffective governance institutions, lack of technological advances, and insufficient management tools. All of these have led to unregulated competition among users, albeit in the context of extensive opportunities offered by the rising demand for seafood. The specific focus of the study is the macroeconomic impact of ocean economy financing in South Africa during the 1994 to 2019 period. The study employed ARDL to test long and short-run relationships. The results show that ocean economy financing in South Africa during this time to have had a positive effect on economic growth, and a negative relationship on unemployment, although the latter is statically insignificant, while ocean economy financing has a negative relationship with entrepreneurship, to have a positive relationship with total trade, and statistically significant. Based on the findings of the study recommendations are made for the South African government to continue investing in oceans economy marine infrastructure and to address any constraints that hinder the growth and sustainability of the country’s ocean economy. In order to ensure the economic viability of ocean ii economy financing four areas need attention, namely economic growth, entrepreneurship, job creation, and total trade. This study recommends that in order to grow the South African economy, a comprehensive growth strategy that looks beyond ocean economy should be adopted. Regarding entrepreneurship ease of doing business should be improved and all factors inhibiting entrepreneurship should be addressed. The requisite skills through human capital investment should be harnessed and decent and sustainable jobs in the ocean sector should be created. It is a well-known fact that an aggressive drive towards economic growth is not without negative externalities e.g pollutions, unreported, unregulated, and over-exploitation of ocean resources. Ocean governance is vital in preventing such negative externalities. The results of the study show that ocean governance boosts trade and reduces unemployment. , Thesis (PHD) -- Faculty of Business and Economic Sciences, 2022
- Full Text:
- Date Issued: 2022-12
- Authors: Matekenya, Weliswa
- Date: 2022-12
- Subjects: Macroeconomics , Maritime –- South Africa
- Language: English
- Type: Doctoral's theses , Thesis
- Identifier: http://hdl.handle.net/10948/60305 , vital:64343
- Description: The global ocean is responsible for providing seafood and employment to the world’s population and is the key driver of global gross domestic product. The ocean economy (blue economy) has been identified as key to unlocking the growth potential of many economies. It is in this context that both the South African government and the private sector have invested in the ocean economy with the purpose of sustaining it and making it more productive. To this end, the government established the Operation Phakisa programme which is meant to fast-track ocean economy development. In line with operation Phakisa imperatives, the South African government began a series of budget allocations towards the various sectors of the oceans economy. This flow of public funds towards oceans economy sectors was with a view to reduce unemployment, grow the economy, increase trade as well as boost entrepreneurship. It is for this reason that the financing of the ocean economy needs to be assessed in terms of its role in ensuring sustainable economic growth through ocean economy activities. While the ocean economy is becoming a new focal point in the discourse on growth and sustainable development both globally and locally, it remains faced with a series of challenges in South Africa. These include inadequate economic incentives, outdated infrastructure, ineffective governance institutions, lack of technological advances, and insufficient management tools. All of these have led to unregulated competition among users, albeit in the context of extensive opportunities offered by the rising demand for seafood. The specific focus of the study is the macroeconomic impact of ocean economy financing in South Africa during the 1994 to 2019 period. The study employed ARDL to test long and short-run relationships. The results show that ocean economy financing in South Africa during this time to have had a positive effect on economic growth, and a negative relationship on unemployment, although the latter is statically insignificant, while ocean economy financing has a negative relationship with entrepreneurship, to have a positive relationship with total trade, and statistically significant. Based on the findings of the study recommendations are made for the South African government to continue investing in oceans economy marine infrastructure and to address any constraints that hinder the growth and sustainability of the country’s ocean economy. In order to ensure the economic viability of ocean ii economy financing four areas need attention, namely economic growth, entrepreneurship, job creation, and total trade. This study recommends that in order to grow the South African economy, a comprehensive growth strategy that looks beyond ocean economy should be adopted. Regarding entrepreneurship ease of doing business should be improved and all factors inhibiting entrepreneurship should be addressed. The requisite skills through human capital investment should be harnessed and decent and sustainable jobs in the ocean sector should be created. It is a well-known fact that an aggressive drive towards economic growth is not without negative externalities e.g pollutions, unreported, unregulated, and over-exploitation of ocean resources. Ocean governance is vital in preventing such negative externalities. The results of the study show that ocean governance boosts trade and reduces unemployment. , Thesis (PHD) -- Faculty of Business and Economic Sciences, 2022
- Full Text:
- Date Issued: 2022-12
Perceptions of blended learning by academic staff in the Health Sciences Faculty at Nelson Mandela University
- Authors: Barry, Janet
- Date: 2021-04
- Subjects: Blended learning -- South Africa -- Nelson Mandela Bay Municipality -- Faculty , Medical sciences -- South Africa -- Nelson Mandela Bay Municipality -- Faculty
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/50999 , vital:43199
- Description: Numerous studies have investigated the use of blended learning by academic staff at tertiary institutions. The purpose of this study was to examine the perceptions of blended learning by academic staff at the Faculty of Health Sciences at Nelson Mandela University. A related objective was to identify barriers and facilitators to the adoption of blended learning by academic staff. A sequential, exploratory mixed-methods design was adopted for this study whereby Phase 1 (focus groups) was used to inform Phase 2 (questionnaire) of the study. Results were analysed from both phases and organised according to strategies, support, and structure of a blended learning adoption framework. Existing support structures to assist with blended learning adoption, understanding of what blended learning is, confidence in using blended learning tools, and time to attend training were some of the findings of the study. The researcher concluded that academic staff in the Health Sciences Faculty at Nelson Mandela University are positioned in the second stage of the blended learning adoption framework, namely the early adoption stage of blended learning. These findings imply that existing strategies and support within the Faculty and the University need to be further developed, and structures put into place to move to an advanced stage of adoption of blended learning by academic staff in Health Sciences Faculty of Nelson Mandela University. , Thesis (MPharm) -- Faculty of Health Sciences, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Barry, Janet
- Date: 2021-04
- Subjects: Blended learning -- South Africa -- Nelson Mandela Bay Municipality -- Faculty , Medical sciences -- South Africa -- Nelson Mandela Bay Municipality -- Faculty
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10948/50999 , vital:43199
- Description: Numerous studies have investigated the use of blended learning by academic staff at tertiary institutions. The purpose of this study was to examine the perceptions of blended learning by academic staff at the Faculty of Health Sciences at Nelson Mandela University. A related objective was to identify barriers and facilitators to the adoption of blended learning by academic staff. A sequential, exploratory mixed-methods design was adopted for this study whereby Phase 1 (focus groups) was used to inform Phase 2 (questionnaire) of the study. Results were analysed from both phases and organised according to strategies, support, and structure of a blended learning adoption framework. Existing support structures to assist with blended learning adoption, understanding of what blended learning is, confidence in using blended learning tools, and time to attend training were some of the findings of the study. The researcher concluded that academic staff in the Health Sciences Faculty at Nelson Mandela University are positioned in the second stage of the blended learning adoption framework, namely the early adoption stage of blended learning. These findings imply that existing strategies and support within the Faculty and the University need to be further developed, and structures put into place to move to an advanced stage of adoption of blended learning by academic staff in Health Sciences Faculty of Nelson Mandela University. , Thesis (MPharm) -- Faculty of Health Sciences, Pharmacy, 2021
- Full Text:
- Date Issued: 2021-04
What are the pertinent intersections in the lives of black women at Rhodes University?
- Authors: Gushman, Lutho Phinda
- Date: 2021-10-29
- Subjects: Women, Black South Africa Makhanda , Student movements South Africa Makhanda , Intersectionality (Sociology) , Pluralism , Matrix organization South Africa Makhanda , Women, Black Education (Higher) South Africa Makhanda , Social action South Africa Makhanda , Rhodes University
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190990 , vital:45047
- Description: After the 2016 #FeesMustFall protest(s), higher education institutions were dramatically altered with respect to their institutional cultures; the narratives of those who were historically side-lined and marginalised took centre stage. At Rhodes University social activism was constitutive of three components; a ‘revolt’ against the fee increment; a contestation of the rape culture; and a rejection of the colonial curriculum. These concerns, in their varied articulations, made up different social and academic realities that define(d) Rhodes University and affected how individuals experienced institutional culture. According to Ndlovu (2017) while these expressed acts (in the form of protests and institutional shutdowns) of resistance against the system of higher education subsided after the fees must fall campaign, these served to centre the narratives of the marginalised. Keeping with this thinking, the argument presented in this thesis explores the experiences of black women in higher education after the call towards coordinated resistance. Using qualitative data in the form of narrative interviews, the thesis documents how the participants continued their academic and social life post-resistance. This rupture of resistance created a complex matrix of individual subjectivity where participants engaged with traditional social academic norms in new spaces of resistance; a phenomenon that enlivened the intersectionality that came to define the higher education landscape of the country. This thesis explores the stories of the participant’s as they engage(d) with what is becoming a new institution—that is the University in South Africa, with a case-in-point being Rhodes University—and to understand the power relations and intersections that define their lived experiences. This study found that the reality of existing within the confines of power—with its fluidity—meant that black women operate both within spaces of privilege and oppression simultaneously. As such, and following Vivian May’s (2015) argument, this study concludes that black women are situated and simultaneously constrained by power. Thus spaces of resistance are constantly in flux and determined by their relations within power. , Thesis (MA) -- Faculty of Humanities, Politics and International Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Gushman, Lutho Phinda
- Date: 2021-10-29
- Subjects: Women, Black South Africa Makhanda , Student movements South Africa Makhanda , Intersectionality (Sociology) , Pluralism , Matrix organization South Africa Makhanda , Women, Black Education (Higher) South Africa Makhanda , Social action South Africa Makhanda , Rhodes University
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190990 , vital:45047
- Description: After the 2016 #FeesMustFall protest(s), higher education institutions were dramatically altered with respect to their institutional cultures; the narratives of those who were historically side-lined and marginalised took centre stage. At Rhodes University social activism was constitutive of three components; a ‘revolt’ against the fee increment; a contestation of the rape culture; and a rejection of the colonial curriculum. These concerns, in their varied articulations, made up different social and academic realities that define(d) Rhodes University and affected how individuals experienced institutional culture. According to Ndlovu (2017) while these expressed acts (in the form of protests and institutional shutdowns) of resistance against the system of higher education subsided after the fees must fall campaign, these served to centre the narratives of the marginalised. Keeping with this thinking, the argument presented in this thesis explores the experiences of black women in higher education after the call towards coordinated resistance. Using qualitative data in the form of narrative interviews, the thesis documents how the participants continued their academic and social life post-resistance. This rupture of resistance created a complex matrix of individual subjectivity where participants engaged with traditional social academic norms in new spaces of resistance; a phenomenon that enlivened the intersectionality that came to define the higher education landscape of the country. This thesis explores the stories of the participant’s as they engage(d) with what is becoming a new institution—that is the University in South Africa, with a case-in-point being Rhodes University—and to understand the power relations and intersections that define their lived experiences. This study found that the reality of existing within the confines of power—with its fluidity—meant that black women operate both within spaces of privilege and oppression simultaneously. As such, and following Vivian May’s (2015) argument, this study concludes that black women are situated and simultaneously constrained by power. Thus spaces of resistance are constantly in flux and determined by their relations within power. , Thesis (MA) -- Faculty of Humanities, Politics and International Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
The importance of learning agility as a component of sustained business success
- Authors: Hennig, Mark Robert
- Date: 2021-04
- Subjects: Success in business -- South Africa , Management -- South Africa , Experiential learning
- Language: English
- Type: Master's/Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/51523 , vital:43295
- Description: The purpose of this treatise is to determine if learning agility is an important component for business success. With the arrival of new technology, change and information explosion the rate of uncertainty is increasing. Leaders are challenged to present continuous change and need to be able to adapt and develop their competencies to remain relevant. The VUCA world increased the complexity of the environment and provide volatility, uncertainty, complexity and are ambiguous. A significant amount of research has been done to define learning agility. The three drivers of learning agility are change, information explosion and rapid response during a crisis. The concept of learning agility can be defined as the readiness and ability to learn from experience and to utilise the learning competency to perform successfully under new environments. The seven-model framework was developed to assess how leaders cope under change. The three leadership competencies are intellectual intelligence, managerial intelligence, and emotional intelligence. Studies shows that emotional intelligence will be an important competency a leader can have and together with learning agility, will provide success to any organisation. The researcher believes that an individual who is not learning agile will not succeed in the new fast-changing environment. The term learning agile is rather a new concept and the influence it has on the organisation is complex. For leaders to succeed, their mindset needs to be adaptable and willing to change. Training and learning from experience will assist the leader to move forward and be an agile leader. A key success factor for organisations is to identify and recruit learning agile individuals to drive competitiveness and enhance relevance in the market. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business Administration, 2021
- Full Text:
- Date Issued: 2021-04
- Authors: Hennig, Mark Robert
- Date: 2021-04
- Subjects: Success in business -- South Africa , Management -- South Africa , Experiential learning
- Language: English
- Type: Master's/Doctoral theses , text
- Identifier: http://hdl.handle.net/10948/51523 , vital:43295
- Description: The purpose of this treatise is to determine if learning agility is an important component for business success. With the arrival of new technology, change and information explosion the rate of uncertainty is increasing. Leaders are challenged to present continuous change and need to be able to adapt and develop their competencies to remain relevant. The VUCA world increased the complexity of the environment and provide volatility, uncertainty, complexity and are ambiguous. A significant amount of research has been done to define learning agility. The three drivers of learning agility are change, information explosion and rapid response during a crisis. The concept of learning agility can be defined as the readiness and ability to learn from experience and to utilise the learning competency to perform successfully under new environments. The seven-model framework was developed to assess how leaders cope under change. The three leadership competencies are intellectual intelligence, managerial intelligence, and emotional intelligence. Studies shows that emotional intelligence will be an important competency a leader can have and together with learning agility, will provide success to any organisation. The researcher believes that an individual who is not learning agile will not succeed in the new fast-changing environment. The term learning agile is rather a new concept and the influence it has on the organisation is complex. For leaders to succeed, their mindset needs to be adaptable and willing to change. Training and learning from experience will assist the leader to move forward and be an agile leader. A key success factor for organisations is to identify and recruit learning agile individuals to drive competitiveness and enhance relevance in the market. , Thesis (MBA) -- Faculty of Business and Economic Sciences, Business Administration, 2021
- Full Text:
- Date Issued: 2021-04
Cultural and social factors affecting crop production at Gqumahashe and Melani, Alice District
- Komanisi, Mzwandile Paul 0000-0003-0866-666X
- Authors: Komanisi, Mzwandile Paul 0000-0003-0866-666X
- Date: 2016-06
- Subjects: Sharecropping , Food crops
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/23023 , vital:55001
- Description: Over the years, sharecropping and work-parties have been seen as variables that maintain social cohesion among people and maximize agricultural production. This study seeks to validate the authenticity of this assertion in the context of two neighbouring villages. Although there are other variables that affect crop production in the study areas, Lower Gqumahashe and Melani, in the light of time constraints and the insignificant impact of these variables, the study focused only on sharecropping and work-parties. The study adopted empirical research design. The researcher realised that empirical research design would offer him an opportunity for intense or prolonged contact with informants in order to have a holistic picture of their behaviour. The researcher did not choose theoretical research design because it would not allow him to have an extensive interaction with informants since it relies on secondary data. The findings of the study suggest that sharecropping and work parties are the main variables that hinder the rate of crop production in the study areas. However, there are other secondary variables hindering crop production but they have insignificant impact. These are clan and kinship relations, political structure, religion and social identity. This study concludes that although local informants were in favour of sharecropping and work-parties in the past, they have discontinued them due to exploitation and hoodwinking. , Thesis (PhD) -- Faculty of Social Science and Humanities, 2016
- Full Text:
- Date Issued: 2016-06
- Authors: Komanisi, Mzwandile Paul 0000-0003-0866-666X
- Date: 2016-06
- Subjects: Sharecropping , Food crops
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10353/23023 , vital:55001
- Description: Over the years, sharecropping and work-parties have been seen as variables that maintain social cohesion among people and maximize agricultural production. This study seeks to validate the authenticity of this assertion in the context of two neighbouring villages. Although there are other variables that affect crop production in the study areas, Lower Gqumahashe and Melani, in the light of time constraints and the insignificant impact of these variables, the study focused only on sharecropping and work-parties. The study adopted empirical research design. The researcher realised that empirical research design would offer him an opportunity for intense or prolonged contact with informants in order to have a holistic picture of their behaviour. The researcher did not choose theoretical research design because it would not allow him to have an extensive interaction with informants since it relies on secondary data. The findings of the study suggest that sharecropping and work parties are the main variables that hinder the rate of crop production in the study areas. However, there are other secondary variables hindering crop production but they have insignificant impact. These are clan and kinship relations, political structure, religion and social identity. This study concludes that although local informants were in favour of sharecropping and work-parties in the past, they have discontinued them due to exploitation and hoodwinking. , Thesis (PhD) -- Faculty of Social Science and Humanities, 2016
- Full Text:
- Date Issued: 2016-06
Optical limiting behavior of ring substituted zinc, indium and gallium phthalocyanines in the presence of quantum dots
- Britton, Jonathan, Litwinski, Christian, Durmus, Mahmut, Chauke, Vongani, Nyokong, Tebello
- Authors: Britton, Jonathan , Litwinski, Christian , Durmus, Mahmut , Chauke, Vongani , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247122 , vital:51548 , xlink:href="https://doi.org/10.1142/S1088424611004142"
- Description: This paper presents the study of the effects of CdTe-TGA quantum dots (QDs) on optical limiting ability of different phthalocyanine (Pc) complexes (1–10) containing Zn, Ga, In central metals and substituted with benzyloxyphenoxy, phenoxy, tert-butylphenoxy and amino groups. The optical limiting parameters of Pcs were higher for tert-butylphenoxy when compared to benzyloxyphenoxy and phenoxy substituents, in DMSO. Non-peripheral substitution decreased the optical limiting parameters. Third-order susceptibility (Im[χ(3)]/α) values of Pcs in the absence and presence of CdTe QDs were in the 10-12 to 10-10 esu.cm range. Hyperpolarizabilities (γ) ranged from 10-31 to 10-29 esu L for Pc alone or in mixture with QDs. There is a general improvement in optical limiting ability of Pc complexes in the presence of CdTe TGA QDs. Due to these promising results, future work can be implemented for the creation of Pc:QD thin films, which would then be examined to ensure that their optical limiting ability is still acceptable.
- Full Text:
- Date Issued: 2011
- Authors: Britton, Jonathan , Litwinski, Christian , Durmus, Mahmut , Chauke, Vongani , Nyokong, Tebello
- Date: 2011
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/247122 , vital:51548 , xlink:href="https://doi.org/10.1142/S1088424611004142"
- Description: This paper presents the study of the effects of CdTe-TGA quantum dots (QDs) on optical limiting ability of different phthalocyanine (Pc) complexes (1–10) containing Zn, Ga, In central metals and substituted with benzyloxyphenoxy, phenoxy, tert-butylphenoxy and amino groups. The optical limiting parameters of Pcs were higher for tert-butylphenoxy when compared to benzyloxyphenoxy and phenoxy substituents, in DMSO. Non-peripheral substitution decreased the optical limiting parameters. Third-order susceptibility (Im[χ(3)]/α) values of Pcs in the absence and presence of CdTe QDs were in the 10-12 to 10-10 esu.cm range. Hyperpolarizabilities (γ) ranged from 10-31 to 10-29 esu L for Pc alone or in mixture with QDs. There is a general improvement in optical limiting ability of Pc complexes in the presence of CdTe TGA QDs. Due to these promising results, future work can be implemented for the creation of Pc:QD thin films, which would then be examined to ensure that their optical limiting ability is still acceptable.
- Full Text:
- Date Issued: 2011