HUMA: A platform for the analysis of genetic variation in humans
- Brown, David K, Tastan Bishop, Özlem
- Authors: Brown, David K , Tastan Bishop, Özlem
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124653 , vital:35642 , https://doi.10.1002/humu.23334
- Description: The completion of the human genome project at the beginning of the 21st century, along with the rapid advancement of sequencing technologies thereafter, has resulted in exponential growth of biological data. In genetics, this has given rise to numerous variation databases, created to store and annotate the ever-expanding dataset of known mutations. Usually, these databases focus on variation at the sequence level. Few databases focus on the analysis of variation at the 3D level, that is, mapping, visualizing, and determining the effects of variation in protein structures. Additionally, these Web servers seldom incorporate tools to help analyze these data. Here, we present the Human Mutation Analysis (HUMA) Web server and database. HUMA integrates sequence, structure, variation, and disease data into a single, connected database. A user-friendly interface provides click-based data access and visualization, whereas a RESTfulWebAPI provides programmatic access to the data. Tools have been integrated into HUMA to allow initial analyses to be carried out on the server. Furthermore, users can upload their private variation datasets, which are automatically mapped to public data and can be analyzed using the integrated tools. HUMA is freely accessible at https://huma.rubi.ru.ac.za.
- Full Text:
- Date Issued: 2018
- Authors: Brown, David K , Tastan Bishop, Özlem
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124653 , vital:35642 , https://doi.10.1002/humu.23334
- Description: The completion of the human genome project at the beginning of the 21st century, along with the rapid advancement of sequencing technologies thereafter, has resulted in exponential growth of biological data. In genetics, this has given rise to numerous variation databases, created to store and annotate the ever-expanding dataset of known mutations. Usually, these databases focus on variation at the sequence level. Few databases focus on the analysis of variation at the 3D level, that is, mapping, visualizing, and determining the effects of variation in protein structures. Additionally, these Web servers seldom incorporate tools to help analyze these data. Here, we present the Human Mutation Analysis (HUMA) Web server and database. HUMA integrates sequence, structure, variation, and disease data into a single, connected database. A user-friendly interface provides click-based data access and visualization, whereas a RESTfulWebAPI provides programmatic access to the data. Tools have been integrated into HUMA to allow initial analyses to be carried out on the server. Furthermore, users can upload their private variation datasets, which are automatically mapped to public data and can be analyzed using the integrated tools. HUMA is freely accessible at https://huma.rubi.ru.ac.za.
- Full Text:
- Date Issued: 2018
The role of structural bioinformatics in drug discovery via computational SNP analysis–a proposed protocol for analyzing variation at the protein level:
- Brown, David K, Tastan Bishop, Özlem
- Authors: Brown, David K , Tastan Bishop, Özlem
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162914 , vital:40996 , doi: 10.1016/j.gheart.2017.01.009
- Description: With the completion of the human genome project at the beginning of the 21st century, the biological sciences entered an unprecedented age of data generation, and made its first steps towards an era of personalized medicine. This abundance of sequence data has led to the proliferation of numerous sequence-based techniques for associating variation with disease, such as Genome-Wide Association Studies (GWAS) and Candidate Gene Association Studies (CGAS). However, these statistical methods do not provide an understanding of the functional effects of variation. Structure-based drug discovery and design is increasingly incorporating structural bioinformatics techniques to model and analyze protein targets, perform large scale virtual screening to identify hit to lead compounds, and simulate molecular interactions. These techniques are fast, cost-effective, and complement existing experimental techniques such as High Throughput Sequencing (HTS).
- Full Text:
- Date Issued: 2017
- Authors: Brown, David K , Tastan Bishop, Özlem
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/162914 , vital:40996 , doi: 10.1016/j.gheart.2017.01.009
- Description: With the completion of the human genome project at the beginning of the 21st century, the biological sciences entered an unprecedented age of data generation, and made its first steps towards an era of personalized medicine. This abundance of sequence data has led to the proliferation of numerous sequence-based techniques for associating variation with disease, such as Genome-Wide Association Studies (GWAS) and Candidate Gene Association Studies (CGAS). However, these statistical methods do not provide an understanding of the functional effects of variation. Structure-based drug discovery and design is increasingly incorporating structural bioinformatics techniques to model and analyze protein targets, perform large scale virtual screening to identify hit to lead compounds, and simulate molecular interactions. These techniques are fast, cost-effective, and complement existing experimental techniques such as High Throughput Sequencing (HTS).
- Full Text:
- Date Issued: 2017
Emancipatory politics and the Mpondo revolts
- Authors: Bruchhausen, Sarah
- Date: 2017
- Subjects: Pondo Revolt, South Africa, 1960-1963 , South Africa -- History -- 20th century , South Africa -- Politics and government -- 20th century
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/5093 , vital:20765
- Description: This thesis aims to offer a revised view of the Mpondo revolts. The central theoretical concept of the thesis is that of emancipatory politics. Drawing predominantly on archival sources the primary concern of the thesis is to expose and interrogate certain aspects of this historical moment of popular politics which can be seen as emancipatory. In particular the notions of egalitarianism and universal human dignity will be analysed in relation to the popular political subjectivities, formations and praxes of the Mpondo revolts. In so doing this thesis attempts to make a meaningful contribution to present day debates concerning alternative theories of human emancipation by showing what emancipatory politics looked like historically and in practise within the context of the Mpondo revolts.
- Full Text:
- Date Issued: 2017
- Authors: Bruchhausen, Sarah
- Date: 2017
- Subjects: Pondo Revolt, South Africa, 1960-1963 , South Africa -- History -- 20th century , South Africa -- Politics and government -- 20th century
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/5093 , vital:20765
- Description: This thesis aims to offer a revised view of the Mpondo revolts. The central theoretical concept of the thesis is that of emancipatory politics. Drawing predominantly on archival sources the primary concern of the thesis is to expose and interrogate certain aspects of this historical moment of popular politics which can be seen as emancipatory. In particular the notions of egalitarianism and universal human dignity will be analysed in relation to the popular political subjectivities, formations and praxes of the Mpondo revolts. In so doing this thesis attempts to make a meaningful contribution to present day debates concerning alternative theories of human emancipation by showing what emancipatory politics looked like historically and in practise within the context of the Mpondo revolts.
- Full Text:
- Date Issued: 2017
Successful delivery of an online higher education course: a quantitative management framework
- Authors: Burger, Dimitri
- Date: 2017
- Subjects: Decision making -- Mathematical models Management -- Mathematical models , Management science Distance education -- South Africa -- Computer-assisted instruction Education, Higher
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/14785 , vital:27850
- Description: South Africa has been experiencing several challenges regarding access to higher education, quality of higher education, effectiveness of higher education course delivery, and funding for higher education. In the higher education sector, the bulk of the burden is placed on traditional higher education institutions, most notably universities, in providing higher education to a growing youth base in dire need of education that supports their individual learning needs. With these challenges facing traditional universities, online higher education provided by both public sector higher education institutions and private sector education providers can act as a valuable alternative and solution to access for some of the population. Online education and face-to-face education differ considerably in how they deliver courses to students. Many have argued that these differences are in some cases attributable to strengths in face-to-face education and drawbacks or limitations in online education, large enough that they should serve as the criteria for selecting the former over the latter as the better mode of delivery. While there have been examples of online programmes that have failed to deliver courses successfully by underutilising or misusing the tools and techniques available, there are positive examples where these programmes perform equally as well as face-to-face courses. The defining difference is ultimately and often the management of these courses’ resources, activities, people, processes, and practices. Considering the above, and with examination of the available literature, a conceptual and theoretical framework was constructed and a quantitative research study was undertaken to prove the significant correlational relationships between elements of course delivery and a management framework to govern those elements. The sample consisted of 115 students from a postgraduate degree programme presented in two formats, online and on-campus. The findings provide evidence of significant relationships between the core functions of management as well as between aspects of course delivery, such as opportunities for interaction, opportunities for feedback, and course content in achieving learning outcomes for students and contributing to engagement. The findings also indicate positive perceptions from students in relation to the delivery of the courses.
- Full Text:
- Date Issued: 2017
- Authors: Burger, Dimitri
- Date: 2017
- Subjects: Decision making -- Mathematical models Management -- Mathematical models , Management science Distance education -- South Africa -- Computer-assisted instruction Education, Higher
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: http://hdl.handle.net/10948/14785 , vital:27850
- Description: South Africa has been experiencing several challenges regarding access to higher education, quality of higher education, effectiveness of higher education course delivery, and funding for higher education. In the higher education sector, the bulk of the burden is placed on traditional higher education institutions, most notably universities, in providing higher education to a growing youth base in dire need of education that supports their individual learning needs. With these challenges facing traditional universities, online higher education provided by both public sector higher education institutions and private sector education providers can act as a valuable alternative and solution to access for some of the population. Online education and face-to-face education differ considerably in how they deliver courses to students. Many have argued that these differences are in some cases attributable to strengths in face-to-face education and drawbacks or limitations in online education, large enough that they should serve as the criteria for selecting the former over the latter as the better mode of delivery. While there have been examples of online programmes that have failed to deliver courses successfully by underutilising or misusing the tools and techniques available, there are positive examples where these programmes perform equally as well as face-to-face courses. The defining difference is ultimately and often the management of these courses’ resources, activities, people, processes, and practices. Considering the above, and with examination of the available literature, a conceptual and theoretical framework was constructed and a quantitative research study was undertaken to prove the significant correlational relationships between elements of course delivery and a management framework to govern those elements. The sample consisted of 115 students from a postgraduate degree programme presented in two formats, online and on-campus. The findings provide evidence of significant relationships between the core functions of management as well as between aspects of course delivery, such as opportunities for interaction, opportunities for feedback, and course content in achieving learning outcomes for students and contributing to engagement. The findings also indicate positive perceptions from students in relation to the delivery of the courses.
- Full Text:
- Date Issued: 2017
Working for ecosystems: an account of how pathways of learning lead to SMME development in a municipal social-ecological programme within a green economy context
- Burger, Margaret Hendrieka Margo
- Authors: Burger, Margaret Hendrieka Margo
- Date: 2017
- Subjects: Working for Ecosystems (South Africa) , Small business -- South Africa , Environmental education -- South Africa -- Durban , Sustainable development -- South Africa -- Durban
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/7735 , vital:21291
- Description: Global climate change alters climatic zones to the extent that species invasion and, in particular, invasive alien plant growth, is regarded as one of the biggest threats to ecosystem functioning. Socio-ecological adaptive management practices have emerged from these threats as opportunities in developing countries where the immediacy of poverty relief acts as a political drawcard and potential for job creation. Local workers in the eThekwini Municipality’s ‘Working for Ecosystems’ biodiversity management programme (WFE) are emerging as micro-enterprise contractors (SMMEs). The transition from worker to entrepreneur has been part of the ethos and long-term planning of the Working for Ecosystems programme at a management level with a view to economic inclusion and realising long-term sustainable livelihoods. Evidence from narratives support claims of transformative outcomes. The findings of this study show that transformation is accessed at various levels: at a management level, at a well-established SMME level and from worker-to- SMME level. These show an “articulation of learning pathways and the connections that are made without a formally structured pathway of learning being in place” (Lotz-Sisitka & Ramsarup, 2013, p. 33). The routes followed to knowledge, practice and sustainability competences by participants in Working for Ecosystems are examined within the complex constellation of material- economic, social-political and cultural-discursive structures and are conceptualised as learning pathways. To fully appreciate the evolving and multidimensional nature of the emergence of SMME practice learning in the Working for Ecosystems programme, relational ontology as a perspective was introduced, with the intention of emphasising the relationship between practice, knowledge and context. Narrative enquiry and extensive data analysis was used as the method to examine workplace learning pathways. These workplace learning pathways can be enriched by more explicitly integrating observation of local and indigenous knowledge of biodiversity in everyday work and practice. However, intermittent contractual work causes disruption in learning pathways formation and results in a lack of stability in conflict with the aims of the programme’s objectives of building capacity and robustness. Findings show that skills development in terms of workplace learning with intersecting, diverse levels of participation and knowledge flow, is particularly important for learning pathways development in the field of invasive alien plant control where divergent values, norms and levels of practice are operational. Prior knowledge, of either indigenous plants or business functioning mechanisms, scaffolds SMME skills through relevance and connected learning in the two fields of practice pertaining to the Working for Ecosystems programme. Clarity of management roles and solidarity within management enhances SMME functioning and learning pathway development for all participants. The Expanded Public Works Programmes (such as Working for Ecosystems) are examined as an opportunity for acquisition of knowledge, competence and new skills development. A prime competence for sustainability understanding is interpersonal skills as these form an essential link with most other competences and as such should be foregrounded in training and learning pathway development. Site selection and time in the programme is a critical factor for expansive learning pathways and environmental stewardship development. Ultimately, in examining and reflecting on the Education for Sustainable Development and green economy potential, it is apparent that learning pathway development needs more support to realise the possibility of entrepreneurship and its political and social significance in terms of sustainable livelihoods. There is a need to recognise diversity, multiple ways of knowing and learning, in learning pathways development “to build joint capacity to cope with complex sustainability challenges” (Wiek, Withycombe, & Redman, 2011).
- Full Text:
- Date Issued: 2017
- Authors: Burger, Margaret Hendrieka Margo
- Date: 2017
- Subjects: Working for Ecosystems (South Africa) , Small business -- South Africa , Environmental education -- South Africa -- Durban , Sustainable development -- South Africa -- Durban
- Language: English
- Type: Thesis , Masters , MEd
- Identifier: http://hdl.handle.net/10962/7735 , vital:21291
- Description: Global climate change alters climatic zones to the extent that species invasion and, in particular, invasive alien plant growth, is regarded as one of the biggest threats to ecosystem functioning. Socio-ecological adaptive management practices have emerged from these threats as opportunities in developing countries where the immediacy of poverty relief acts as a political drawcard and potential for job creation. Local workers in the eThekwini Municipality’s ‘Working for Ecosystems’ biodiversity management programme (WFE) are emerging as micro-enterprise contractors (SMMEs). The transition from worker to entrepreneur has been part of the ethos and long-term planning of the Working for Ecosystems programme at a management level with a view to economic inclusion and realising long-term sustainable livelihoods. Evidence from narratives support claims of transformative outcomes. The findings of this study show that transformation is accessed at various levels: at a management level, at a well-established SMME level and from worker-to- SMME level. These show an “articulation of learning pathways and the connections that are made without a formally structured pathway of learning being in place” (Lotz-Sisitka & Ramsarup, 2013, p. 33). The routes followed to knowledge, practice and sustainability competences by participants in Working for Ecosystems are examined within the complex constellation of material- economic, social-political and cultural-discursive structures and are conceptualised as learning pathways. To fully appreciate the evolving and multidimensional nature of the emergence of SMME practice learning in the Working for Ecosystems programme, relational ontology as a perspective was introduced, with the intention of emphasising the relationship between practice, knowledge and context. Narrative enquiry and extensive data analysis was used as the method to examine workplace learning pathways. These workplace learning pathways can be enriched by more explicitly integrating observation of local and indigenous knowledge of biodiversity in everyday work and practice. However, intermittent contractual work causes disruption in learning pathways formation and results in a lack of stability in conflict with the aims of the programme’s objectives of building capacity and robustness. Findings show that skills development in terms of workplace learning with intersecting, diverse levels of participation and knowledge flow, is particularly important for learning pathways development in the field of invasive alien plant control where divergent values, norms and levels of practice are operational. Prior knowledge, of either indigenous plants or business functioning mechanisms, scaffolds SMME skills through relevance and connected learning in the two fields of practice pertaining to the Working for Ecosystems programme. Clarity of management roles and solidarity within management enhances SMME functioning and learning pathway development for all participants. The Expanded Public Works Programmes (such as Working for Ecosystems) are examined as an opportunity for acquisition of knowledge, competence and new skills development. A prime competence for sustainability understanding is interpersonal skills as these form an essential link with most other competences and as such should be foregrounded in training and learning pathway development. Site selection and time in the programme is a critical factor for expansive learning pathways and environmental stewardship development. Ultimately, in examining and reflecting on the Education for Sustainable Development and green economy potential, it is apparent that learning pathway development needs more support to realise the possibility of entrepreneurship and its political and social significance in terms of sustainable livelihoods. There is a need to recognise diversity, multiple ways of knowing and learning, in learning pathways development “to build joint capacity to cope with complex sustainability challenges” (Wiek, Withycombe, & Redman, 2011).
- Full Text:
- Date Issued: 2017
Forage production, nutritive value and intake rates by goats of pigeon pea (Cajanus cajan (L.) forages grown in the subtropical region of South Africa
- Authors: Buthelezi, Lindokuhle Sizwe
- Date: 2017
- Subjects: Forage Pigeon pea Forage plants
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10353/7852 , vital:30773
- Description: Different growth stages and drying methods were used to assess forage production, nutritive value and intake of leaves from three Cajanus cajan varieties (ICEAP 00557, ICEAP 01514 and CIMMYT 100/01). In the 2016/17 growing season, three complete randomized block designs (CRBD’s) were conducted. Regrowth parameters were measured during both the both vegetative and flowering stages. The plots were harvested at the flowering stage. Biomass yields were measured at the flowering stage. The harvested leaves were then dried under the two different drying methods. The methods used were shade- and oven-drying at 60 oC. This was used to determine dry matter (DM), crude protein (CP), neutral detergent fibre (NDF), acid detergent fibre (ADF), acid detergent lignin (ADL) and total non-structural carbohydrates (TNC) for the C. cajan varieties. Minerals Ca, Mg, K, Na, K/(Ca+Mg), P and Zn, Cu, Mn and Fe and phytochemicals condensed tannins, phenolic compounds and saponins were also analyzed. The intake rates and in vitro and in sacco ruminal degradabilities were also determined. The survival percentage was significantly different (P<0.05) only across the means of varieties. There was no significant difference (P>0.05) in the number of shoots per plant, stems per shoot and coppice stems produced by the three C. cajan varieties at vegetative and flowering stage. There was a significant difference (P<0.05) in the heights of plants recorded by the varieties only at flowering stage. The yields of fresh biomass in C. cajan was significantly different (P<0.05) across all the varieties harvested in 2016. In all the varieties there was a significant difference (P<0.05) in dry matter yield in both seasons of 2016 and 2017. The effect of browse varieties and drying methods showed a significant effect (P<0.05) on DM, CP, fat, NDIN, ADIN and hemicellulose content of varieties. There was little impact by varieties and drying methods (P<0.05) on ash, NDF, ADF, ADL, TNC and cellulose content of varieties. Varieties and drying method had no effect (P>0.05) on Ca, Mg and K except for Na and P. There was no effect caused by varieties and drying methods (P>0.05) on Zn and Mn with Cu and Fe being the exceptions. Oven drying showed an overall reduction in the tannin concentration on leaves while there was an increase in saponins. The different varieties had no effect (P>0.05) on the IIR, 0.0275±0.0089, 0.0275±0.0077 and 0.0409±0.0109 for Cv1, Cv2 and Cv3, respectively. The day of the trial and browse variety had an effect (P<0.05) on bite rate. However, the day of trial had no significant effect (P>0.05) on both bite size and the instantaneous intake rate. Individual goat had a significant effect (P<0.05) on bite rate. There was a significant difference (P<0.05) in the in vitro and in sacco rapidly degradable fractions (a) of all the three varieties but the drying method had no effect (P>0.05). The slowly degradable fraction (b) and degradation rate constant (c) of all varieties was not significantly different (P>0.05) on both drying methods during IV DaisyII procedure. However, b and c, in all the varieties was significantly different (P<0.05) in both drying methods during the in sacco procedure. There was no significant difference (P>0.05) in the mean potentially degradable fraction (a+b) across all C. cajan varieties during IV DaisyII procedure, however a+c of all varieties was significantly different (P<0.05) in both the drying methods during the in sacco procedure. The effective in vitro and in sacco degradability of the varieties was significantly different (P<0.05) with a rumen outflow rate of 2, 5 and 8 percent per hour. The shade-dried varieties had a higher (P<0.05) ED than the oven-dried materials during IV DaisyII and the in sacco procedures. It was concluded that the decline in yield of C. cajan during the study is a reflection of poor survival, the insufficient regeneration from seed, nutrient depletion over time and the extended dry seasons. Therefore, shade drying is commended method of drying forages.
- Full Text:
- Date Issued: 2017
- Authors: Buthelezi, Lindokuhle Sizwe
- Date: 2017
- Subjects: Forage Pigeon pea Forage plants
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10353/7852 , vital:30773
- Description: Different growth stages and drying methods were used to assess forage production, nutritive value and intake of leaves from three Cajanus cajan varieties (ICEAP 00557, ICEAP 01514 and CIMMYT 100/01). In the 2016/17 growing season, three complete randomized block designs (CRBD’s) were conducted. Regrowth parameters were measured during both the both vegetative and flowering stages. The plots were harvested at the flowering stage. Biomass yields were measured at the flowering stage. The harvested leaves were then dried under the two different drying methods. The methods used were shade- and oven-drying at 60 oC. This was used to determine dry matter (DM), crude protein (CP), neutral detergent fibre (NDF), acid detergent fibre (ADF), acid detergent lignin (ADL) and total non-structural carbohydrates (TNC) for the C. cajan varieties. Minerals Ca, Mg, K, Na, K/(Ca+Mg), P and Zn, Cu, Mn and Fe and phytochemicals condensed tannins, phenolic compounds and saponins were also analyzed. The intake rates and in vitro and in sacco ruminal degradabilities were also determined. The survival percentage was significantly different (P<0.05) only across the means of varieties. There was no significant difference (P>0.05) in the number of shoots per plant, stems per shoot and coppice stems produced by the three C. cajan varieties at vegetative and flowering stage. There was a significant difference (P<0.05) in the heights of plants recorded by the varieties only at flowering stage. The yields of fresh biomass in C. cajan was significantly different (P<0.05) across all the varieties harvested in 2016. In all the varieties there was a significant difference (P<0.05) in dry matter yield in both seasons of 2016 and 2017. The effect of browse varieties and drying methods showed a significant effect (P<0.05) on DM, CP, fat, NDIN, ADIN and hemicellulose content of varieties. There was little impact by varieties and drying methods (P<0.05) on ash, NDF, ADF, ADL, TNC and cellulose content of varieties. Varieties and drying method had no effect (P>0.05) on Ca, Mg and K except for Na and P. There was no effect caused by varieties and drying methods (P>0.05) on Zn and Mn with Cu and Fe being the exceptions. Oven drying showed an overall reduction in the tannin concentration on leaves while there was an increase in saponins. The different varieties had no effect (P>0.05) on the IIR, 0.0275±0.0089, 0.0275±0.0077 and 0.0409±0.0109 for Cv1, Cv2 and Cv3, respectively. The day of the trial and browse variety had an effect (P<0.05) on bite rate. However, the day of trial had no significant effect (P>0.05) on both bite size and the instantaneous intake rate. Individual goat had a significant effect (P<0.05) on bite rate. There was a significant difference (P<0.05) in the in vitro and in sacco rapidly degradable fractions (a) of all the three varieties but the drying method had no effect (P>0.05). The slowly degradable fraction (b) and degradation rate constant (c) of all varieties was not significantly different (P>0.05) on both drying methods during IV DaisyII procedure. However, b and c, in all the varieties was significantly different (P<0.05) in both drying methods during the in sacco procedure. There was no significant difference (P>0.05) in the mean potentially degradable fraction (a+b) across all C. cajan varieties during IV DaisyII procedure, however a+c of all varieties was significantly different (P<0.05) in both the drying methods during the in sacco procedure. The effective in vitro and in sacco degradability of the varieties was significantly different (P<0.05) with a rumen outflow rate of 2, 5 and 8 percent per hour. The shade-dried varieties had a higher (P<0.05) ED than the oven-dried materials during IV DaisyII and the in sacco procedures. It was concluded that the decline in yield of C. cajan during the study is a reflection of poor survival, the insufficient regeneration from seed, nutrient depletion over time and the extended dry seasons. Therefore, shade drying is commended method of drying forages.
- Full Text:
- Date Issued: 2017
The effect of the Marikana events on the collective bargaining process in South Africa
- Authors: Butjie, Boitumelo Cordelia
- Date: 2017
- Subjects: Collective bargaining -- Mining industry , Strikes and lockouts -- Miners -- South Africa -- Marikana
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: http://hdl.handle.net/10948/9239 , vital:26482
- Description: The basic structures of collective bargaining in South Africa have evolved since industrialisation, through the Wiehahn-Commission era until the Farlam one and beyond, resulting in a number of legislative changes from 1924 to 2014. While dealing with collective bargaining, it is not possible to divorce the powerful history of mining from the South African story, from the diamond fields in Kimberley to the discovery of gold on the Witwatersrand in 1886, where the mine employees’ focused on cheap, unskilled labour and migrant system in the 1900s to the tragic events at Marikana in 2012. In the advent of the industry revolution, employment relationships changed as competitive demands placed a great need for advancing economic developments which are often expressed through collective-bargaining. The objective of collective bargaining is to arrive at an agreement between the employer and employees to determine mutually beneficial terms and conditions of employment such agreement may prohibit unions to embark on an industrial action for as long as it is in place. Strikes became important during the Industrial Revolution, when many worked in factories and mines. Often when employees’ demands are not met, they resort to strike action. Strike action is when a number of employees stop rendering their service in protest to express their grievances. These strikes are usually led by labour unions to get better pay, working hours or working conditions during collective bargaining as a last resort. While trade union leadership fails to advance employees’ cause, employees resort to informal alternative structures to negotiate on their behalf. South Africans have a tradition of taking to the streets in protest when unhappy about issues and this tradition did not spring up during the apartheid era but has been around from as early as 1922 to date. Protests in South Africa today draw from past repertoires and at the same time push for new political practices and directions. Strikes are often used to: Pressure governments to change its policies like in the Rand Revolt; Strikes can destabilise the rule of a particular political party like a series of strikes by blacks in the 1970s and 1980s including the 1973 Durban dockworkers and the 1987 miners’ strikes; Strikes are often part of a broader social movement taking the form of a campaign of civil resistance like Treatment Action Campaign and community struggles such Abahlali Base Mjondolo. On the strike issues in South Africa, the researcher draws from the terrible incident that transpired in August 2012 at Lonmin Mine-Marikana and how it has affected the collective bargaining landscape in South Africa. The first real and significant labour unrest, the Witwatersrand miner strike rocked South Africa to the core in 1922 and in 2012, ninety years later the violent strike by the Rock Operational Drillers at Lonmin following the Marikana massacre and as such did not enjoy statutory protection under the LRA because was classified as wildcat strike. Normally, a wildcat strike constitutes a violation of a collective bargaining agreement in place and as such is not protected unless a union joins it and ratifies the protest. The union may, however, discipline its members for participating in a wildcat strike and impose fines. Among other things miners mainly demanded a wage increment of R12500 per month. The fight between AMCU and NUM for organisational rights also found its way into the equation. A strike wave, not only linked to the mining sector, made 2012 the most protest filled year since the end of apartheid, rolled out across South Africa, closing some industrial operations and crippling others. Commentators argue that the strike wave emerged from a landscape of extreme inequality and poverty, made intolerable by the additional financial burdens arising from the migrant labour system. These factors influenced the industrial action and institutions of collective bargaining comprising of both company and union structures and processes, were found wanting in their ability to address the root causes of the crisis. The post-Marikana strike wave made a mark in the workers struggle movement as it drew in thousands of workers to join AMCU and at the same time weakening NUM, the then majority union. The strike led to the rise and growth of AMCU which was seen by miners as the driver for change. The 2012 strike wave and the Marikana massacre not only changed the balance of forces on the ground against the NUM, but also generated divisions within COSATU. The divisions were between those who decided to remain deaf to the workers’ call for transformation and those who had already realised that a decisive turn in economic policy was needed to avoid a social, economic and political crisis. In the aftermath of the strike, a number community struggles increased as 2012 began and on the other side, a number of splinter groups from COSATU mushroomed which was hobbled by in fights. NUM’s collapse is indeed part of a series of recent failures for COSATU.
- Full Text:
- Date Issued: 2017
- Authors: Butjie, Boitumelo Cordelia
- Date: 2017
- Subjects: Collective bargaining -- Mining industry , Strikes and lockouts -- Miners -- South Africa -- Marikana
- Language: English
- Type: Thesis , Masters , LLM
- Identifier: http://hdl.handle.net/10948/9239 , vital:26482
- Description: The basic structures of collective bargaining in South Africa have evolved since industrialisation, through the Wiehahn-Commission era until the Farlam one and beyond, resulting in a number of legislative changes from 1924 to 2014. While dealing with collective bargaining, it is not possible to divorce the powerful history of mining from the South African story, from the diamond fields in Kimberley to the discovery of gold on the Witwatersrand in 1886, where the mine employees’ focused on cheap, unskilled labour and migrant system in the 1900s to the tragic events at Marikana in 2012. In the advent of the industry revolution, employment relationships changed as competitive demands placed a great need for advancing economic developments which are often expressed through collective-bargaining. The objective of collective bargaining is to arrive at an agreement between the employer and employees to determine mutually beneficial terms and conditions of employment such agreement may prohibit unions to embark on an industrial action for as long as it is in place. Strikes became important during the Industrial Revolution, when many worked in factories and mines. Often when employees’ demands are not met, they resort to strike action. Strike action is when a number of employees stop rendering their service in protest to express their grievances. These strikes are usually led by labour unions to get better pay, working hours or working conditions during collective bargaining as a last resort. While trade union leadership fails to advance employees’ cause, employees resort to informal alternative structures to negotiate on their behalf. South Africans have a tradition of taking to the streets in protest when unhappy about issues and this tradition did not spring up during the apartheid era but has been around from as early as 1922 to date. Protests in South Africa today draw from past repertoires and at the same time push for new political practices and directions. Strikes are often used to: Pressure governments to change its policies like in the Rand Revolt; Strikes can destabilise the rule of a particular political party like a series of strikes by blacks in the 1970s and 1980s including the 1973 Durban dockworkers and the 1987 miners’ strikes; Strikes are often part of a broader social movement taking the form of a campaign of civil resistance like Treatment Action Campaign and community struggles such Abahlali Base Mjondolo. On the strike issues in South Africa, the researcher draws from the terrible incident that transpired in August 2012 at Lonmin Mine-Marikana and how it has affected the collective bargaining landscape in South Africa. The first real and significant labour unrest, the Witwatersrand miner strike rocked South Africa to the core in 1922 and in 2012, ninety years later the violent strike by the Rock Operational Drillers at Lonmin following the Marikana massacre and as such did not enjoy statutory protection under the LRA because was classified as wildcat strike. Normally, a wildcat strike constitutes a violation of a collective bargaining agreement in place and as such is not protected unless a union joins it and ratifies the protest. The union may, however, discipline its members for participating in a wildcat strike and impose fines. Among other things miners mainly demanded a wage increment of R12500 per month. The fight between AMCU and NUM for organisational rights also found its way into the equation. A strike wave, not only linked to the mining sector, made 2012 the most protest filled year since the end of apartheid, rolled out across South Africa, closing some industrial operations and crippling others. Commentators argue that the strike wave emerged from a landscape of extreme inequality and poverty, made intolerable by the additional financial burdens arising from the migrant labour system. These factors influenced the industrial action and institutions of collective bargaining comprising of both company and union structures and processes, were found wanting in their ability to address the root causes of the crisis. The post-Marikana strike wave made a mark in the workers struggle movement as it drew in thousands of workers to join AMCU and at the same time weakening NUM, the then majority union. The strike led to the rise and growth of AMCU which was seen by miners as the driver for change. The 2012 strike wave and the Marikana massacre not only changed the balance of forces on the ground against the NUM, but also generated divisions within COSATU. The divisions were between those who decided to remain deaf to the workers’ call for transformation and those who had already realised that a decisive turn in economic policy was needed to avoid a social, economic and political crisis. In the aftermath of the strike, a number community struggles increased as 2012 began and on the other side, a number of splinter groups from COSATU mushroomed which was hobbled by in fights. NUM’s collapse is indeed part of a series of recent failures for COSATU.
- Full Text:
- Date Issued: 2017
Evidence for protandry in Polydactylus quadrifilis in the Kwanza Estuary, Angola, and its implications for local fisheries
- Butler, Edward C, Childs, Amber-Robyn, Winkler, Alexander C, Milner, Marianne V, Potts, Warren M
- Authors: Butler, Edward C , Childs, Amber-Robyn , Winkler, Alexander C , Milner, Marianne V , Potts, Warren M
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124451 , vital:35614 , https://doi.10.1007/s10641-017-0699-6
- Description: A total of 141 Polydactylus quadrifilis were sampled from the Kwanza Estuary in Angola ranging in size from 436 to 1360 mm fork-length (FL). Of these, 124 were male, six intersex and 11 female. Female fish were significantly longer (mm, FL) and heavier (kg) than males and had significantly higher gonadosomatic indices (GSI’s) than those of males and intersex fish. Transitional (intersex) gonads were delimited, with testicular and ovarian regions separated by connective tissue. The first signs of ovarian tissue appeared on the outer ventral surface of the gonad. A second layer of ovarian tissue was first noticeable at either end of the initial ovarian region and developed back towards the centre of the ventral wall to form a luminal space. Early-stage oocytes were commonly found in the outer area of male regions and residual late-stage spermatids and spermatozoa were found in the luminal space of ovarian regions, suggesting a process of sex change from the outside inwards. A loss of male function was noted with increased ovarian prevalence. Based on this evidence it is suggested that P. quadrifilis in the Kwanza Estuary are protandrous. Owing to the reliance of P. quadrifilis on large highly fecund females for egg production, it is likely that they will be sensitive to fishing practices that target larger individuals within the population.
- Full Text:
- Date Issued: 2018
- Authors: Butler, Edward C , Childs, Amber-Robyn , Winkler, Alexander C , Milner, Marianne V , Potts, Warren M
- Date: 2018
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124451 , vital:35614 , https://doi.10.1007/s10641-017-0699-6
- Description: A total of 141 Polydactylus quadrifilis were sampled from the Kwanza Estuary in Angola ranging in size from 436 to 1360 mm fork-length (FL). Of these, 124 were male, six intersex and 11 female. Female fish were significantly longer (mm, FL) and heavier (kg) than males and had significantly higher gonadosomatic indices (GSI’s) than those of males and intersex fish. Transitional (intersex) gonads were delimited, with testicular and ovarian regions separated by connective tissue. The first signs of ovarian tissue appeared on the outer ventral surface of the gonad. A second layer of ovarian tissue was first noticeable at either end of the initial ovarian region and developed back towards the centre of the ventral wall to form a luminal space. Early-stage oocytes were commonly found in the outer area of male regions and residual late-stage spermatids and spermatozoa were found in the luminal space of ovarian regions, suggesting a process of sex change from the outside inwards. A loss of male function was noted with increased ovarian prevalence. Based on this evidence it is suggested that P. quadrifilis in the Kwanza Estuary are protandrous. Owing to the reliance of P. quadrifilis on large highly fecund females for egg production, it is likely that they will be sensitive to fishing practices that target larger individuals within the population.
- Full Text:
- Date Issued: 2018
The action of sutherlandia frutescens on macrophage differentiation & function
- Authors: Camille, Ned
- Date: 2017
- Subjects: Medicinal plants Macrophages
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/22112 , vital:29841
- Description: Sutherlandia frutescens (S. frutescens) is a medicinal plant, indigenous to South Africa used to treat various conditions, including Type II Diabetes (T2D) and immune disorders. Many of these conditions involve the macrophage lineage in low grade chronic inflammation, characterized by elevated pro-inflammatory cytokines. The macrophage population can be divided into pro-inflammatory (M1) and anti-inflammatory (M2) sub-populations. S. frutescens is believed to possess the potential to regulate macrophage differentiation and metabolic immune diseases. This makes it important to investigate its molecular action to determine its potential ethnopharmacological use. The aims of this study were to explore the role of S. frutescens on M1/M2 macrophage function, using extracts prepared from a single plant source previously shown to target T2D, and to determine its potential mechanistic pathways using the murine macrophage-like RAW 264.7 cell line. The action of a hot aqueous and a 100% ethanolic extract of S. frutescens were tested in the RAW 264.7 cell line following Lipopolysaccharide (LPS) induction. The effect of these extracts on activation of a pro-inflammatory M1 phenotype and an anti-inflammatory M2 phenotype was investigated by flow cytometry using the CD markers CD86 (M1) and CD206 (M2). M1 macrophage pro-inflammatory responses were measured by production of nitric oxide (NO) using the Griess reagent and reactive oxygen species (ROS) production and cyclooxygenase 2 (COX-2) expression by flow cytometry. Cytokine production was quantified by ELISA assays. Toll-like receptor-4 (TLR4), inducible nitric oxide synthase (iNOS) (M1) and Heme-oxygenase 1 (HMOX-1) (M2) mRNA expression were quantified by quantitative reverse transcription polymerase chain reaction (RT-qPCR). Arginase-1 activity (M2) was measured by the urea assay. The effect of S. frutescens extracts on nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) and mitogen activated protein kinases (MAPK) signaling pathway were determined with flow cytometry and Image Express XLS microscopy. After 24 hour treatment, both the hot aqueous and ethanolic extracts of S. frutescens significantly inhibited all M1 functions, and altered the pattern of CD expression from M1 (CD86+) to M2 (CD206+) in RAW 264.7 cells following activation by LPS, with the ethanolic extract having the greatest activity. M1-type cytokines were downregulated, while the M2 cytokine profile remained unchanged. S. frutescens was shown to mediate its action through suppression of both NF-κB and MAPK pathways and not through HMOX-1, exerting most activity through decreased p38 MAPK phosphorylation. We show that S. frutescens aids in the potential reversal of imbalances in the macrophage M1 and M2 sub-populations, leading to amelioration of disease. We hypothesize that regulation occurs during the differentiation and activation processes, with reduction in inflammation and direction towards M2 anti-inflammatory activity. This could promote tissue remodeling and immune regulation and has potential to alleviate the pathogenesis of both T2D and immune diseases.
- Full Text:
- Date Issued: 2017
- Authors: Camille, Ned
- Date: 2017
- Subjects: Medicinal plants Macrophages
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10948/22112 , vital:29841
- Description: Sutherlandia frutescens (S. frutescens) is a medicinal plant, indigenous to South Africa used to treat various conditions, including Type II Diabetes (T2D) and immune disorders. Many of these conditions involve the macrophage lineage in low grade chronic inflammation, characterized by elevated pro-inflammatory cytokines. The macrophage population can be divided into pro-inflammatory (M1) and anti-inflammatory (M2) sub-populations. S. frutescens is believed to possess the potential to regulate macrophage differentiation and metabolic immune diseases. This makes it important to investigate its molecular action to determine its potential ethnopharmacological use. The aims of this study were to explore the role of S. frutescens on M1/M2 macrophage function, using extracts prepared from a single plant source previously shown to target T2D, and to determine its potential mechanistic pathways using the murine macrophage-like RAW 264.7 cell line. The action of a hot aqueous and a 100% ethanolic extract of S. frutescens were tested in the RAW 264.7 cell line following Lipopolysaccharide (LPS) induction. The effect of these extracts on activation of a pro-inflammatory M1 phenotype and an anti-inflammatory M2 phenotype was investigated by flow cytometry using the CD markers CD86 (M1) and CD206 (M2). M1 macrophage pro-inflammatory responses were measured by production of nitric oxide (NO) using the Griess reagent and reactive oxygen species (ROS) production and cyclooxygenase 2 (COX-2) expression by flow cytometry. Cytokine production was quantified by ELISA assays. Toll-like receptor-4 (TLR4), inducible nitric oxide synthase (iNOS) (M1) and Heme-oxygenase 1 (HMOX-1) (M2) mRNA expression were quantified by quantitative reverse transcription polymerase chain reaction (RT-qPCR). Arginase-1 activity (M2) was measured by the urea assay. The effect of S. frutescens extracts on nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) and mitogen activated protein kinases (MAPK) signaling pathway were determined with flow cytometry and Image Express XLS microscopy. After 24 hour treatment, both the hot aqueous and ethanolic extracts of S. frutescens significantly inhibited all M1 functions, and altered the pattern of CD expression from M1 (CD86+) to M2 (CD206+) in RAW 264.7 cells following activation by LPS, with the ethanolic extract having the greatest activity. M1-type cytokines were downregulated, while the M2 cytokine profile remained unchanged. S. frutescens was shown to mediate its action through suppression of both NF-κB and MAPK pathways and not through HMOX-1, exerting most activity through decreased p38 MAPK phosphorylation. We show that S. frutescens aids in the potential reversal of imbalances in the macrophage M1 and M2 sub-populations, leading to amelioration of disease. We hypothesize that regulation occurs during the differentiation and activation processes, with reduction in inflammation and direction towards M2 anti-inflammatory activity. This could promote tissue remodeling and immune regulation and has potential to alleviate the pathogenesis of both T2D and immune diseases.
- Full Text:
- Date Issued: 2017
Using iterative learning to improve understanding during the informed consent process in a South African psychiatric genomics study
- Campbell, Megan M, Susser, Ezra, Mall, Sumaya, Mqulwana, Sibonile G, Mndini, Michael M, Ntola, Odwa A, Nagdee, Mohamed, Zingela, Zukiswa, Van Wyk, Stephanus, Stein, Dan J
- Authors: Campbell, Megan M , Susser, Ezra , Mall, Sumaya , Mqulwana, Sibonile G , Mndini, Michael M , Ntola, Odwa A , Nagdee, Mohamed , Zingela, Zukiswa , Van Wyk, Stephanus , Stein, Dan J
- Date: 2017
- Subjects: Informed consent (Medical law) , Patient education
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6114 , vital:45124 , https://doi.org/10.1371/journal.pone.0188466
- Description: Obtaining informed consent is a great challenge in global health research. There is a need for tools that can screen for and improve potential research participants’ understanding of the research study at the time of recruitment. Limited empirical research has been conducted in low and middle income countries, evaluating informed consent processes in genomics research. We sought to investigate the quality of informed consent obtained in a South African psychiatric genomics study. A Xhosa language version of the University of California, San Diego Brief Assessment of Capacity to Consent Questionnaire (UBACC) was used to screen for capacity to consent and improve understanding through iterative learning in a sample of 528 Xhosa people with schizophrenia and 528 controls. We address two questions: firstly, whether research participants’ understanding of the research study improved through iterative learning; and secondly, what were predictors for better understanding of the research study at the initial screening? During screening 290 (55%) cases and 172 (33%) controls scored below the 14.5 cut-off for acceptable understanding of the research study elements, however after iterative learning only 38 (7%) cases and 13 (2.5%) controls continued to score below this cut-off. Significant variables associated with increased understanding of the consent included the psychiatric nurse recruiter conducting the consent screening, higher participant level of education, and being a control. The UBACC proved an effective tool to improve understanding of research study elements during consent, for both cases and controls. The tool holds utility for complex studies such as those involving genomics, where iterative learning can be used to make significant improvements in understanding of research study elements. The UBACC may be particularly important in groups with severe mental illness and lower education levels. Study recruiters play a significant role in managing the quality of the informed consent process.
- Full Text:
- Date Issued: 2017
- Authors: Campbell, Megan M , Susser, Ezra , Mall, Sumaya , Mqulwana, Sibonile G , Mndini, Michael M , Ntola, Odwa A , Nagdee, Mohamed , Zingela, Zukiswa , Van Wyk, Stephanus , Stein, Dan J
- Date: 2017
- Subjects: Informed consent (Medical law) , Patient education
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/11260/6114 , vital:45124 , https://doi.org/10.1371/journal.pone.0188466
- Description: Obtaining informed consent is a great challenge in global health research. There is a need for tools that can screen for and improve potential research participants’ understanding of the research study at the time of recruitment. Limited empirical research has been conducted in low and middle income countries, evaluating informed consent processes in genomics research. We sought to investigate the quality of informed consent obtained in a South African psychiatric genomics study. A Xhosa language version of the University of California, San Diego Brief Assessment of Capacity to Consent Questionnaire (UBACC) was used to screen for capacity to consent and improve understanding through iterative learning in a sample of 528 Xhosa people with schizophrenia and 528 controls. We address two questions: firstly, whether research participants’ understanding of the research study improved through iterative learning; and secondly, what were predictors for better understanding of the research study at the initial screening? During screening 290 (55%) cases and 172 (33%) controls scored below the 14.5 cut-off for acceptable understanding of the research study elements, however after iterative learning only 38 (7%) cases and 13 (2.5%) controls continued to score below this cut-off. Significant variables associated with increased understanding of the consent included the psychiatric nurse recruiter conducting the consent screening, higher participant level of education, and being a control. The UBACC proved an effective tool to improve understanding of research study elements during consent, for both cases and controls. The tool holds utility for complex studies such as those involving genomics, where iterative learning can be used to make significant improvements in understanding of research study elements. The UBACC may be particularly important in groups with severe mental illness and lower education levels. Study recruiters play a significant role in managing the quality of the informed consent process.
- Full Text:
- Date Issued: 2017
Experiences of analogue-trained radiographers utilising digital imaging in projection radiography
- Authors: Campbell, Sydney
- Date: 2017
- Subjects: Radiography, Medical -- Digital techniques Angiography , Image processing -- Digital techniques Radiography
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: http://hdl.handle.net/10948/14796 , vital:27851
- Description: The professional work of a radiographer encompasses both patient care and the use of technology. The technology employed could either be analogue or digital technology. Since 1973, the analogue imaging system has slowly been replaced by digital radiography imaging systems. Despite the many advantages of digital imaging it does present the radiographer with added responsibilities. Furthermore, analogue-trained radiographers have found adjusting to digital imaging especially challenging. The aim of the study was to explore and describe the experiences of analogue-trained radiographers utilising digital imaging in projection radiography with the intention of developing guidelines to equip radiography managers to assist analogue-trained radiographers to better utilise digital imaging. The researcher used Schlossberg’s Transition Theory as a lens to look at the experiences of analogue-trained radiographers using digital imaging to produce radiographs. The research study used a qualitative design which was explorative, descriptive and contextual in nature. The target population included all diagnostic radiographers (public and private) in the local municipality who were registered with the Health Professions Council of South Africa. Purposive sampling was employed to select the radiographers that represented all radiographers in the Nelson Mandela Bay Health District. The sample included all radiographers who fulfilled the identified selection criteria. The selected participants were recruited to take part in in-depth, semi-structured individual interviews. The data was analysed using a computer-aided qualitative data analysis software package, ATLAS.ti. The trustworthiness of this study was ensured by applying Guba’s model of trustworthiness that includes credibility, transferability, dependability and confirmability. The ethical principles of respect for persons, beneficence and justice, as espoused by the Belmont Report, were adhered to in order to ensure that the study was conducted in an ethical manner. Two themes emanated from the data, namely the evolution of the radiographer when faced with the advances in technology as well the role that the work environment played in the manner that the participants experienced the change. The experiences of the participants were described using direct quotations from the interviews and a literature control was used to verify the participants’ experiences. Evidence was found of radiographer indifference towards exposure selection, dose optimisation and placement of anatomical side markers when utilising digital imaging. Finally, guidelines were developed to equip radiography managers to assist analogue-trained radiographers to better utilise digital imaging. In addition, the guidelines will assist all other radiographers to better utilise digital imaging.
- Full Text:
- Date Issued: 2017
- Authors: Campbell, Sydney
- Date: 2017
- Subjects: Radiography, Medical -- Digital techniques Angiography , Image processing -- Digital techniques Radiography
- Language: English
- Type: Thesis , Masters , MTech
- Identifier: http://hdl.handle.net/10948/14796 , vital:27851
- Description: The professional work of a radiographer encompasses both patient care and the use of technology. The technology employed could either be analogue or digital technology. Since 1973, the analogue imaging system has slowly been replaced by digital radiography imaging systems. Despite the many advantages of digital imaging it does present the radiographer with added responsibilities. Furthermore, analogue-trained radiographers have found adjusting to digital imaging especially challenging. The aim of the study was to explore and describe the experiences of analogue-trained radiographers utilising digital imaging in projection radiography with the intention of developing guidelines to equip radiography managers to assist analogue-trained radiographers to better utilise digital imaging. The researcher used Schlossberg’s Transition Theory as a lens to look at the experiences of analogue-trained radiographers using digital imaging to produce radiographs. The research study used a qualitative design which was explorative, descriptive and contextual in nature. The target population included all diagnostic radiographers (public and private) in the local municipality who were registered with the Health Professions Council of South Africa. Purposive sampling was employed to select the radiographers that represented all radiographers in the Nelson Mandela Bay Health District. The sample included all radiographers who fulfilled the identified selection criteria. The selected participants were recruited to take part in in-depth, semi-structured individual interviews. The data was analysed using a computer-aided qualitative data analysis software package, ATLAS.ti. The trustworthiness of this study was ensured by applying Guba’s model of trustworthiness that includes credibility, transferability, dependability and confirmability. The ethical principles of respect for persons, beneficence and justice, as espoused by the Belmont Report, were adhered to in order to ensure that the study was conducted in an ethical manner. Two themes emanated from the data, namely the evolution of the radiographer when faced with the advances in technology as well the role that the work environment played in the manner that the participants experienced the change. The experiences of the participants were described using direct quotations from the interviews and a literature control was used to verify the participants’ experiences. Evidence was found of radiographer indifference towards exposure selection, dose optimisation and placement of anatomical side markers when utilising digital imaging. Finally, guidelines were developed to equip radiography managers to assist analogue-trained radiographers to better utilise digital imaging. In addition, the guidelines will assist all other radiographers to better utilise digital imaging.
- Full Text:
- Date Issued: 2017
Investigating herbivory and plant origin on tall-statured grasses in South Africa
- Authors: Canavan, Kim
- Date: 2017
- Subjects: Insects as biological pest control agents -- South Africa , Arundo donax , Giant reed -- South Africa , Giant reed -- Biological control -- South Africa , Phragmites australis , Phragmites mauritianus , Phragmites , Tetramesa romana , Biological invasions -- South Africa , Wasps -- Host plants , Wasps -- South Africa
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/6147 , vital:21051
- Description: South African riparian zones have been heavily degraded through anthropogenic activities such as dam construction and extraction of water for irrigation, which has resulted in a loss of ecosystem services and functioning. A consequence of such disturbances to riparian areas is in their susceptibility to invasive alien species (IAS). One such IAS is the giant reed, Arundo donax L. (Poaceae), introduced to South Africa in the 1700s largely for erosion control. Arundo donax has since greatly expanded in the country and is now one of the most abundant IAS. Arundo donax has been found to displace native vegetation and in South Africa this will most likely lead to the displacement of the native tall-statured grasses, Phragmites australis (Cav.) Trin. ex Steud. and Phragmites mauritianus Kunth. This study aimed to enhance our understanding of the tall-statured grasses A. donax, P. australis and P. mauritianus to better manage them in riparian areas. For A. donax, biological control is seen as the most viable option to control stands in the long-term. However, before such a programme is put in place, it is important to first collect baseline data that can be used to guide the direction of the biological control project in South Africa. For the Phragmites spp., despite being a dominant vegetative type in riparian areas, very little is known about their status in South Africa. Furthermore, there have been increasing reports of both Phragmites species having an expansion of their range and abundance. In North America, there has been a similar trend of reed expansion and through molecular work it was determined that a cryptic invasion has occurred with the introduction of an invasive non-native haplotype from Europe. It is therefore unknown if Phragmites spp. populations are expanding due to anthropogenic activities or due to a cryptic invasion. To address these shortfalls in knowledge the study investigated the tall-statured grasses in two parts; firstly, molecular techniques are used to explore the plant origin and genetic diversity of A. donax, P. australis and P. mauritianus and secondly using the Enemy Release Hypothesis as a framework, herbivore assemblages for each reed was determined across their distribution in South Africa. Molecular-techniques determined that both P. australis and P. mauritianus had only one haplotype - known as haplotype K and haplotype V respectively, across their distribution. For P. australis, haplotype K shares a close connection with populations from a Mediterranean lineage and this was further confirmed with a shared grass-waxy band. The direction and timing of genetic exchange between the two regions could not be ascertained and thus still remains unknown. Microsatellite analysis determined that both Phragmites spp. had a high genetic diversity compared to worldwide lineages. With no evidence of any cryptic invasions of haplotypes from other regions, both Phragmites spp. populations are likely to be native to South Africa. For A. donax all populations across South Africa were determined to be haplotype M1; a cosmopolitan haplotype that has an ancient native range in Afghanistan and Pakistan (Indus Valley). Populations were found to have no genetic diversity and thus can be considered one clone. A pre-introductory survey determined a list of herbivores associated with each tall- statured grass. For A. donax, a total of seven herbivores were found. Of these, one herbivore, a galling wasp, Tetramesa romana Walker (Hymenoptera: Eurytomidae) was found to be highly abundant and widely distributed in South Africa. Tetramesa romana is already a biological control agent in North America and thus is likely exerting some pressure on A. donax populations in South Africa. For both Phragmites spp. a total of ten herbivores were found, although having higher species richness compared to A. donax, when compared to other regions, these native species have a relatively low species richness. Providing baseline data on plant origin, genetic diversity and herbivory on A. donax, P. australis and P. mauritianus has provided important information on managing these species in riparian ecosystems in South Africa. For the Phragmites spp. with no evidence of any cryptic invasions, it is recommended that reed stands continue to be managed as native species. Phragmites spp. are important dominant vegetative species and thus should be protected; however, if reed stands become expansive, control methods can be put in place to focus on managing spread and abundance. For A. donax, this study was able to provide pivotal information in guiding the biological control programme. By determining the ancient lineage of South African populations, research can be focused in this area to find potential biological control agents. Lastly, the pre-introductory survey determined that a biological control agent, T. romana was already established with an unknown introduction and also highlighted potential plant parts that should be targeted. In particular, no rhizome feeding herbivores were found in South Africa and therefore this highlights an important niche that should be explored in biological control agents.
- Full Text:
- Date Issued: 2017
- Authors: Canavan, Kim
- Date: 2017
- Subjects: Insects as biological pest control agents -- South Africa , Arundo donax , Giant reed -- South Africa , Giant reed -- Biological control -- South Africa , Phragmites australis , Phragmites mauritianus , Phragmites , Tetramesa romana , Biological invasions -- South Africa , Wasps -- Host plants , Wasps -- South Africa
- Language: English
- Type: text , Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/6147 , vital:21051
- Description: South African riparian zones have been heavily degraded through anthropogenic activities such as dam construction and extraction of water for irrigation, which has resulted in a loss of ecosystem services and functioning. A consequence of such disturbances to riparian areas is in their susceptibility to invasive alien species (IAS). One such IAS is the giant reed, Arundo donax L. (Poaceae), introduced to South Africa in the 1700s largely for erosion control. Arundo donax has since greatly expanded in the country and is now one of the most abundant IAS. Arundo donax has been found to displace native vegetation and in South Africa this will most likely lead to the displacement of the native tall-statured grasses, Phragmites australis (Cav.) Trin. ex Steud. and Phragmites mauritianus Kunth. This study aimed to enhance our understanding of the tall-statured grasses A. donax, P. australis and P. mauritianus to better manage them in riparian areas. For A. donax, biological control is seen as the most viable option to control stands in the long-term. However, before such a programme is put in place, it is important to first collect baseline data that can be used to guide the direction of the biological control project in South Africa. For the Phragmites spp., despite being a dominant vegetative type in riparian areas, very little is known about their status in South Africa. Furthermore, there have been increasing reports of both Phragmites species having an expansion of their range and abundance. In North America, there has been a similar trend of reed expansion and through molecular work it was determined that a cryptic invasion has occurred with the introduction of an invasive non-native haplotype from Europe. It is therefore unknown if Phragmites spp. populations are expanding due to anthropogenic activities or due to a cryptic invasion. To address these shortfalls in knowledge the study investigated the tall-statured grasses in two parts; firstly, molecular techniques are used to explore the plant origin and genetic diversity of A. donax, P. australis and P. mauritianus and secondly using the Enemy Release Hypothesis as a framework, herbivore assemblages for each reed was determined across their distribution in South Africa. Molecular-techniques determined that both P. australis and P. mauritianus had only one haplotype - known as haplotype K and haplotype V respectively, across their distribution. For P. australis, haplotype K shares a close connection with populations from a Mediterranean lineage and this was further confirmed with a shared grass-waxy band. The direction and timing of genetic exchange between the two regions could not be ascertained and thus still remains unknown. Microsatellite analysis determined that both Phragmites spp. had a high genetic diversity compared to worldwide lineages. With no evidence of any cryptic invasions of haplotypes from other regions, both Phragmites spp. populations are likely to be native to South Africa. For A. donax all populations across South Africa were determined to be haplotype M1; a cosmopolitan haplotype that has an ancient native range in Afghanistan and Pakistan (Indus Valley). Populations were found to have no genetic diversity and thus can be considered one clone. A pre-introductory survey determined a list of herbivores associated with each tall- statured grass. For A. donax, a total of seven herbivores were found. Of these, one herbivore, a galling wasp, Tetramesa romana Walker (Hymenoptera: Eurytomidae) was found to be highly abundant and widely distributed in South Africa. Tetramesa romana is already a biological control agent in North America and thus is likely exerting some pressure on A. donax populations in South Africa. For both Phragmites spp. a total of ten herbivores were found, although having higher species richness compared to A. donax, when compared to other regions, these native species have a relatively low species richness. Providing baseline data on plant origin, genetic diversity and herbivory on A. donax, P. australis and P. mauritianus has provided important information on managing these species in riparian ecosystems in South Africa. For the Phragmites spp. with no evidence of any cryptic invasions, it is recommended that reed stands continue to be managed as native species. Phragmites spp. are important dominant vegetative species and thus should be protected; however, if reed stands become expansive, control methods can be put in place to focus on managing spread and abundance. For A. donax, this study was able to provide pivotal information in guiding the biological control programme. By determining the ancient lineage of South African populations, research can be focused in this area to find potential biological control agents. Lastly, the pre-introductory survey determined that a biological control agent, T. romana was already established with an unknown introduction and also highlighted potential plant parts that should be targeted. In particular, no rhizome feeding herbivores were found in South Africa and therefore this highlights an important niche that should be explored in biological control agents.
- Full Text:
- Date Issued: 2017
Composition portfolio
- Authors: Caplan, Anthony
- Date: 2017
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10962/6940 , vital:21202
- Description: Restricted access-thesis available at the Music Library
- Full Text: false
- Date Issued: 2017
- Authors: Caplan, Anthony
- Date: 2017
- Language: English
- Type: text , Thesis , Masters , MMus
- Identifier: http://hdl.handle.net/10962/6940 , vital:21202
- Description: Restricted access-thesis available at the Music Library
- Full Text: false
- Date Issued: 2017
Monolingualism and its meaning in two KwaZulu-Natal high schools
- Authors: Carlyle, Jacqui
- Date: 2017
- Subjects: Monolingualism -- South Africa , Monolingualism -- South Africa -- Case studies , Language awareness -- South Africa , Language and education -- South Africa , School children -- South Africa -- Attitudes , School children -- South Africa -- Attitudes -- Case studies , African languages -- Study and teaching -- South Africa -- Attitudes
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/6543 , vital:21135
- Description: This study reports on the identity and attitudes of monolingual English speakers (MES) at two high schools in Durban, South Africa, in relation particularly to the role and meaning of monolingualism. Two bodies of data are used to investigate the attitudes of MES and are oriented towards four variables: English, African languages (particularly Zulu), monolingualism and plurilingualism. The attitudes to these variables reveal the impact on identity of language usage in Durban, and negotiations of the participants in trying to mitigate or justify attitudes that are counter to the embracing of diversity encouraged in modern South Africa. First, an attitude questionnaire provides quantitative data that is subjected to analysis, including a chi-squared test. Second, a narrative elicitation interview provides qualitative narrative data that is analysed in relation to APPRAISAL theory. Both analysis types are used to ascertain the presence of a monolingual mindset in the scholars’ responses, as well as to capture the ideological forces to which they are subjected as monolingual English speakers in the unique multilingual setting of Durban. In essence, the data points to a discourse of compromise and unease on the part of the participants - as they juggle with the effects of an English-centric monolingual mindset, and a more pervasive pluralism that embraces the Rainbowism of ‘the new South Africa’. This discourse of compromise is characterized on one side by insecurity and dissatisfaction with the language in education policy, and well as the monolingual upbringing of MES in Durban, and a lack of Language other than English (LOTE), in particular, Zulu. This side of the compromise also portrays a pro- plurilingual orientation, a positive valuation of knowing a LOTE and of plurilingual people. Here, however, the manifestation of the ‘other side’ of the compromise appears as the MES characterize plurilingualism as exceptional and too difficult, and language learning at school as having a negative impact on academic success. Alongside this is a normalization of English and othering of African languages in practical situation. English is also promoted as the language of unity and economic and academic progress or success, while the material value of African languages is questioned.
- Full Text:
- Date Issued: 2017
- Authors: Carlyle, Jacqui
- Date: 2017
- Subjects: Monolingualism -- South Africa , Monolingualism -- South Africa -- Case studies , Language awareness -- South Africa , Language and education -- South Africa , School children -- South Africa -- Attitudes , School children -- South Africa -- Attitudes -- Case studies , African languages -- Study and teaching -- South Africa -- Attitudes
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10962/6543 , vital:21135
- Description: This study reports on the identity and attitudes of monolingual English speakers (MES) at two high schools in Durban, South Africa, in relation particularly to the role and meaning of monolingualism. Two bodies of data are used to investigate the attitudes of MES and are oriented towards four variables: English, African languages (particularly Zulu), monolingualism and plurilingualism. The attitudes to these variables reveal the impact on identity of language usage in Durban, and negotiations of the participants in trying to mitigate or justify attitudes that are counter to the embracing of diversity encouraged in modern South Africa. First, an attitude questionnaire provides quantitative data that is subjected to analysis, including a chi-squared test. Second, a narrative elicitation interview provides qualitative narrative data that is analysed in relation to APPRAISAL theory. Both analysis types are used to ascertain the presence of a monolingual mindset in the scholars’ responses, as well as to capture the ideological forces to which they are subjected as monolingual English speakers in the unique multilingual setting of Durban. In essence, the data points to a discourse of compromise and unease on the part of the participants - as they juggle with the effects of an English-centric monolingual mindset, and a more pervasive pluralism that embraces the Rainbowism of ‘the new South Africa’. This discourse of compromise is characterized on one side by insecurity and dissatisfaction with the language in education policy, and well as the monolingual upbringing of MES in Durban, and a lack of Language other than English (LOTE), in particular, Zulu. This side of the compromise also portrays a pro- plurilingual orientation, a positive valuation of knowing a LOTE and of plurilingual people. Here, however, the manifestation of the ‘other side’ of the compromise appears as the MES characterize plurilingualism as exceptional and too difficult, and language learning at school as having a negative impact on academic success. Alongside this is a normalization of English and othering of African languages in practical situation. English is also promoted as the language of unity and economic and academic progress or success, while the material value of African languages is questioned.
- Full Text:
- Date Issued: 2017
From contradictions to complementarities: a social realist analysis of the evolution of academic development within a department
- Case, Jennifer M, Heydenrych, Hilton, Kotta, Linda, Marshall, Delia, McKenna, Sioux, Willliams, Kevin
- Authors: Case, Jennifer M , Heydenrych, Hilton , Kotta, Linda , Marshall, Delia , McKenna, Sioux , Willliams, Kevin
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66752 , vital:28990 , ISSN 1470-1294 , https://doi.org/10.1080/03075079.2015.1045479
- Description: Publisher version , Academic development is a recent project in the university, intended to enable the university to respond to the needs of a more diverse student body. In South Africa, such work arose during late apartheid, and has now moved to a more central institutional position advocating responsiveness in the light of the educational disparities that are the legacy of apartheid. The present study uses a social realist perspective to analyse the 25-year evolution of an academic development project within an engineering department at a South African university. The findings show that while academic development initially posed a contradictory logic to the department, the response was to reform the nature of this project into one that suited the other commitments of the department: a logic of complementarity. The department's relationships with industry were shown to have played a key role in fostering this form of change.
- Full Text: false
- Date Issued: 2017
- Authors: Case, Jennifer M , Heydenrych, Hilton , Kotta, Linda , Marshall, Delia , McKenna, Sioux , Willliams, Kevin
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/66752 , vital:28990 , ISSN 1470-1294 , https://doi.org/10.1080/03075079.2015.1045479
- Description: Publisher version , Academic development is a recent project in the university, intended to enable the university to respond to the needs of a more diverse student body. In South Africa, such work arose during late apartheid, and has now moved to a more central institutional position advocating responsiveness in the light of the educational disparities that are the legacy of apartheid. The present study uses a social realist perspective to analyse the 25-year evolution of an academic development project within an engineering department at a South African university. The findings show that while academic development initially posed a contradictory logic to the department, the response was to reform the nature of this project into one that suited the other commitments of the department: a logic of complementarity. The department's relationships with industry were shown to have played a key role in fostering this form of change.
- Full Text: false
- Date Issued: 2017
Male youth leaders’ perceptions and experiences of young men’s constructions of domestic violence against women and its prevention
- Authors: Catazo, Ntombizandile
- Date: 2017
- Subjects: Family violence -- Prevention , Women -- Crimes against Child abuse Social work with youth
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/14807 , vital:27852
- Description: South Africa is faced with many social problems; amongst them is domestic violence, a dilemma which is experienced by almost all racial groups. There is a widespread belief that social learning and patriarchy perpetuate this dilemma, as is evident in theories. Many studies on domestic violence have focused on the experiences of women and there is a gap on how men view it against women. Research had to be conducted on young men’s views on this issue. The researcher in this study sought to explore the male youth leaders’ perceptions of domestic violence against women and its prevention. The study utilised generic qualitative methods based on the explorative, descriptive and contextual design to gather information. In-depth interviews were conducted with each participant. The study employed semi-structured interviews using snowball sampling. A sample of male youth leaders in Port Elizabeth participated in the interviews of the study. Data was verified using member checking, peer debriefing, clarifying bias by the researcher, and dense description of the application of the selected methods used in the research. The major findings of this study include men as main perpetrators of violence, patriarchy as a cause of domestic violence, men not knowing and not involved into prevention programmes for domestic violence. The findings will contribute into the prevention of domestic violence.
- Full Text:
- Date Issued: 2017
- Authors: Catazo, Ntombizandile
- Date: 2017
- Subjects: Family violence -- Prevention , Women -- Crimes against Child abuse Social work with youth
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/14807 , vital:27852
- Description: South Africa is faced with many social problems; amongst them is domestic violence, a dilemma which is experienced by almost all racial groups. There is a widespread belief that social learning and patriarchy perpetuate this dilemma, as is evident in theories. Many studies on domestic violence have focused on the experiences of women and there is a gap on how men view it against women. Research had to be conducted on young men’s views on this issue. The researcher in this study sought to explore the male youth leaders’ perceptions of domestic violence against women and its prevention. The study utilised generic qualitative methods based on the explorative, descriptive and contextual design to gather information. In-depth interviews were conducted with each participant. The study employed semi-structured interviews using snowball sampling. A sample of male youth leaders in Port Elizabeth participated in the interviews of the study. Data was verified using member checking, peer debriefing, clarifying bias by the researcher, and dense description of the application of the selected methods used in the research. The major findings of this study include men as main perpetrators of violence, patriarchy as a cause of domestic violence, men not knowing and not involved into prevention programmes for domestic violence. The findings will contribute into the prevention of domestic violence.
- Full Text:
- Date Issued: 2017
Effects of substituents on the electrocatalytic activity of cobalt phthalocyanines when conjugated to graphene quantum dots
- Centane, Sixolile, Achadu, Ojodomo John, Nyokong, Tebello
- Authors: Centane, Sixolile , Achadu, Ojodomo John , Nyokong, Tebello
- Date: 2017
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/188237 , vital:44737 , xlink:href="https://doi.org/10.1002/elan.201700252"
- Description: We report on the π–π interactions between graphene quantum dots (GQDs) and the following cobalt phthalocyanine derivatives: cobalt monocarboxyphenoxy phthalocyanine (complex 1), cobalt tetracarboxyphenoxyphthalocyanine (complex 2), and cobalt tetraaminophenoxy phthalocyanine (complex 3). The conjugates (conj) with GQDs are represented as 1@GQDs(conj), 2@GQDs(conj) and 3@GQDs(conj), respectively. The resulting phthalocyanine/GQDs conjugates were adsorbed on containing a glassy carbon electrode (GCE) using the drop and dry method. We explore the electrochemical properties of phthalocyanines functionalized with both electron withdrawing groups and electron donating groups when non-covalently linked to the π-electron rich graphene quantum dots. GCE/3, GCE/2@GQDs(conj) and GCE/1@GQDs(conj) had the lowest limits of detection (LOD). Sequentially modified electrodes showed less favourable detection limits compared to the conjugates.
- Full Text:
- Date Issued: 2017
- Authors: Centane, Sixolile , Achadu, Ojodomo John , Nyokong, Tebello
- Date: 2017
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/188237 , vital:44737 , xlink:href="https://doi.org/10.1002/elan.201700252"
- Description: We report on the π–π interactions between graphene quantum dots (GQDs) and the following cobalt phthalocyanine derivatives: cobalt monocarboxyphenoxy phthalocyanine (complex 1), cobalt tetracarboxyphenoxyphthalocyanine (complex 2), and cobalt tetraaminophenoxy phthalocyanine (complex 3). The conjugates (conj) with GQDs are represented as 1@GQDs(conj), 2@GQDs(conj) and 3@GQDs(conj), respectively. The resulting phthalocyanine/GQDs conjugates were adsorbed on containing a glassy carbon electrode (GCE) using the drop and dry method. We explore the electrochemical properties of phthalocyanines functionalized with both electron withdrawing groups and electron donating groups when non-covalently linked to the π-electron rich graphene quantum dots. GCE/3, GCE/2@GQDs(conj) and GCE/1@GQDs(conj) had the lowest limits of detection (LOD). Sequentially modified electrodes showed less favourable detection limits compared to the conjugates.
- Full Text:
- Date Issued: 2017
Artist in Residence: Rehema Chachage
- Authors: Chachage, Rehema
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146479 , vital:38529 , https://www.ru.ac.za/artsofafrica/exhibitionsperformances/inzwi/
- Description: Inzwi! was an art event during the 2017 National Arts Festival in Grahamstown that celebrated the 5th anniversary of the Lucid Lunchbox, a student-led series of talks linked to the Arts of Africa and Global Souths research programme at Rhodes University. During the festival, five sets composed of three videos interjected the talks presented by Dineo Seshee Bopape and Beth Diane Armstrong, as well as a conversation between Andrew Tshabangu, Thembinkosi Goniwe and Philiswa Lila. The event intended to trigger reflection and dialogue, through a ‘wake-up call’ to grapple with our collective heritage and struggles, our fears and points of departure in order to envision futures. The selection of videos drew from the work of Rhodes Fine Art students, Alumni and Artists in Residence. Works on display addressed matters of identity (social, political and/or fictional); social engagement and activism; religious and spiritual practices in African contexts; race and white supremacy; and, finally, patronising relations in the art world. Borrowing from the words of Weléla Mar Kindred, the choreography of this event, like others that have been propelling black body politics in recent movements, is one of "communal healing, strength and solidarity".
- Full Text:
- Date Issued: 2017
- Authors: Chachage, Rehema
- Date: 2017
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/146479 , vital:38529 , https://www.ru.ac.za/artsofafrica/exhibitionsperformances/inzwi/
- Description: Inzwi! was an art event during the 2017 National Arts Festival in Grahamstown that celebrated the 5th anniversary of the Lucid Lunchbox, a student-led series of talks linked to the Arts of Africa and Global Souths research programme at Rhodes University. During the festival, five sets composed of three videos interjected the talks presented by Dineo Seshee Bopape and Beth Diane Armstrong, as well as a conversation between Andrew Tshabangu, Thembinkosi Goniwe and Philiswa Lila. The event intended to trigger reflection and dialogue, through a ‘wake-up call’ to grapple with our collective heritage and struggles, our fears and points of departure in order to envision futures. The selection of videos drew from the work of Rhodes Fine Art students, Alumni and Artists in Residence. Works on display addressed matters of identity (social, political and/or fictional); social engagement and activism; religious and spiritual practices in African contexts; race and white supremacy; and, finally, patronising relations in the art world. Borrowing from the words of Weléla Mar Kindred, the choreography of this event, like others that have been propelling black body politics in recent movements, is one of "communal healing, strength and solidarity".
- Full Text:
- Date Issued: 2017
A new synthetic approach for preparation of Efavirenz
- Authors: Chada, Sravanthi
- Date: 2017
- Subjects: Antiretroviral agents , Asymmetric synthesis , Enzyme inhibitors , HIV (Viruses) -- Enzymes
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/15512 , vital:28265
- Description: Efavirenz, a drug that is still inaccessible to millions of people worldwide, is potent non nucleoside reverse transcriptase inhibitor (NNRTI), is one of the preferred agents used in combination therapy for first-line treatment of the human immunodeficiency virus (HIV). NNRTIs attach to and block an HIV enzyme called reverse transcriptase, by blocking reverse transcriptase; NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body. Efavirenz can't cure HIV/AIDS, but taken in combination with other HIV medicines (called an HIV regimen) every day helps people with HIV live longer healthier lives. Efavirenz also reduces the risk of HIV transmission and can be used by children who are suffering from HIV/AIDS. All the above therapeutic uses of efavirenz prompted us to identify the novel and hopefully cost efficient synthetic methodology for the preparation of efavirenz. In this thesis a new synthetic method for asymmetric synthesis of efavirenz is described. This route started from commercially available starting materials and it is first established in traditional batch chemistry and further the parameters transferred to a semi continuous flow protocol for optimization.
- Full Text:
- Date Issued: 2017
- Authors: Chada, Sravanthi
- Date: 2017
- Subjects: Antiretroviral agents , Asymmetric synthesis , Enzyme inhibitors , HIV (Viruses) -- Enzymes
- Language: English
- Type: Thesis , Doctoral , PhD
- Identifier: http://hdl.handle.net/10948/15512 , vital:28265
- Description: Efavirenz, a drug that is still inaccessible to millions of people worldwide, is potent non nucleoside reverse transcriptase inhibitor (NNRTI), is one of the preferred agents used in combination therapy for first-line treatment of the human immunodeficiency virus (HIV). NNRTIs attach to and block an HIV enzyme called reverse transcriptase, by blocking reverse transcriptase; NNRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body. Efavirenz can't cure HIV/AIDS, but taken in combination with other HIV medicines (called an HIV regimen) every day helps people with HIV live longer healthier lives. Efavirenz also reduces the risk of HIV transmission and can be used by children who are suffering from HIV/AIDS. All the above therapeutic uses of efavirenz prompted us to identify the novel and hopefully cost efficient synthetic methodology for the preparation of efavirenz. In this thesis a new synthetic method for asymmetric synthesis of efavirenz is described. This route started from commercially available starting materials and it is first established in traditional batch chemistry and further the parameters transferred to a semi continuous flow protocol for optimization.
- Full Text:
- Date Issued: 2017
Voices of the hungry: A qualitative measure of household food access and food insecurity in South Africa
- Chakona, Gamucharai, Shackleton, Charlie M
- Authors: Chakona, Gamucharai , Shackleton, Charlie M
- Date: 2017
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/398443 , vital:69412 , xlink:href="https://doi.org/10.1186/s40066-017-0149-x"
- Description: South Africa is rated a food secure nation, but large numbers of households within the country have inadequate access to nutrient-rich diverse foods. The study sought to investigate households’ physical and economic access and availability of food, in relation to local context which influences households’ access to and ability to grow food which may affect the dietary quality. We sought to understand self-reported healthy diets, food insecurity from the perspective of people who experienced it, barriers to household food security and perceptions and feelings on food access as well as strategies households use to cope with food shortages and their perceptions on improving household food security.
- Full Text:
- Date Issued: 2017
- Authors: Chakona, Gamucharai , Shackleton, Charlie M
- Date: 2017
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/398443 , vital:69412 , xlink:href="https://doi.org/10.1186/s40066-017-0149-x"
- Description: South Africa is rated a food secure nation, but large numbers of households within the country have inadequate access to nutrient-rich diverse foods. The study sought to investigate households’ physical and economic access and availability of food, in relation to local context which influences households’ access to and ability to grow food which may affect the dietary quality. We sought to understand self-reported healthy diets, food insecurity from the perspective of people who experienced it, barriers to household food security and perceptions and feelings on food access as well as strategies households use to cope with food shortages and their perceptions on improving household food security.
- Full Text:
- Date Issued: 2017