The syntheses and photophysical properties of 4, 4′-isopropylidendioxydiphenyl substituted ball-type dinuclear Mg (II) and Zn (II) phthalocyanines
- Canlıca, Mevlüde, Nyokong, Tebello
- Authors: Canlıca, Mevlüde , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/243554 , vital:51163 , xlink:href="https://doi.org/10.1016/j.poly.2011.10.024"
- Description: The syntheses of ball-type dinuclear Zn(II) and Mg(II) phthalocyanines containing four 4,4′-isopropylidendioxydiphenyl substituents at the peripheral and non-peripheral positions are presented. The structures of the synthesized compounds were characterized using elemental analyses, and UV–Vis, FT-IR, 1H NMR and mass spectroscopies. The ΦF values were 0.14, 0.11, 0.22, 0.15 and ΦT values were 0.84, 0.88, 0.62, 0.74, for 6–9, respectively. The largest triplet yields were observed for the non-peripherally substituted complexes 6 and 7, showing that non-peripheral substitution favors increased population of the triplet state. All complexes showed reasonably long triplet lifetimes with τT 510, 310, 910 and 350 μs in DMSO, respectively.
- Full Text:
- Date Issued: 2012
- Authors: Canlıca, Mevlüde , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/243554 , vital:51163 , xlink:href="https://doi.org/10.1016/j.poly.2011.10.024"
- Description: The syntheses of ball-type dinuclear Zn(II) and Mg(II) phthalocyanines containing four 4,4′-isopropylidendioxydiphenyl substituents at the peripheral and non-peripheral positions are presented. The structures of the synthesized compounds were characterized using elemental analyses, and UV–Vis, FT-IR, 1H NMR and mass spectroscopies. The ΦF values were 0.14, 0.11, 0.22, 0.15 and ΦT values were 0.84, 0.88, 0.62, 0.74, for 6–9, respectively. The largest triplet yields were observed for the non-peripherally substituted complexes 6 and 7, showing that non-peripheral substitution favors increased population of the triplet state. All complexes showed reasonably long triplet lifetimes with τT 510, 310, 910 and 350 μs in DMSO, respectively.
- Full Text:
- Date Issued: 2012
Schottky barrier diode parameters of Ag/MgPc/p-Si structure
- Canlıca, Mevlüde, Coskun, Mustafa, Altındal, Ahmet, Nyokong, Tebello
- Authors: Canlıca, Mevlüde , Coskun, Mustafa , Altındal, Ahmet , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/245820 , vital:51408 , xlink:href="https://doi.org/10.1142/S1088424612500824"
- Description: An Ag/Pc/p-Si Schottky barrier (SB) diode was fabricated. The current-voltage (I-V), capacitance-voltage (C-V) and conductance-voltage (G-V) measurements were carried out to determine the characteristic parameters such as barrier height, ideality factor and series resistance of the SB diode. The non-linear behavior of ln (I) vs. ln (V) and ln (I/V) vs. V1/2 plots indicated that the thermoionic emission theory can be applied to evaluate junction parameters for the investigated SB diode rather than space-charge limited conduction (SCLC) mechanism and bulk-limited Poole–Frenkel emission. The bulk doping concentration NB and fixed oxide charges Nf was determined from the measured high frequency C-V curve and was found to be 9.5 × 1014 cm-3 and 2.3 × 1013 cm-2, respectively. The values of barrier height obtained from Norde's function were compared with those from the forward bias current-voltage characteristic, and it was seen that there was a good agreement between barrier heights from both methods.
- Full Text:
- Date Issued: 2012
- Authors: Canlıca, Mevlüde , Coskun, Mustafa , Altındal, Ahmet , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/245820 , vital:51408 , xlink:href="https://doi.org/10.1142/S1088424612500824"
- Description: An Ag/Pc/p-Si Schottky barrier (SB) diode was fabricated. The current-voltage (I-V), capacitance-voltage (C-V) and conductance-voltage (G-V) measurements were carried out to determine the characteristic parameters such as barrier height, ideality factor and series resistance of the SB diode. The non-linear behavior of ln (I) vs. ln (V) and ln (I/V) vs. V1/2 plots indicated that the thermoionic emission theory can be applied to evaluate junction parameters for the investigated SB diode rather than space-charge limited conduction (SCLC) mechanism and bulk-limited Poole–Frenkel emission. The bulk doping concentration NB and fixed oxide charges Nf was determined from the measured high frequency C-V curve and was found to be 9.5 × 1014 cm-3 and 2.3 × 1013 cm-2, respectively. The values of barrier height obtained from Norde's function were compared with those from the forward bias current-voltage characteristic, and it was seen that there was a good agreement between barrier heights from both methods.
- Full Text:
- Date Issued: 2012
The synthesis, photophysical and dielectric properties of ball-type dinuclear zinc phthalocyanine
- Canlıca, Mevlüde, Altındal, Ahmet, Nyokong, Tebello
- Authors: Canlıca, Mevlüde , Altındal, Ahmet , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/243532 , vital:51161 , xlink:href="https://doi.org/10.1142/S1088424612500836"
- Description: The synthesis of ball-type dinuclear Zn(II) phthalocyanine containing four 4,4′-(9H-fluorene-9,9-diyl)diphenol substituents at the non-peripheral position is presented. The structure of the synthesized compound was characterized using elemental analyzes, and UV-vis, FT-IR, 1H NMR and mass spectroscopies. The ΦF value was 0.16 and ΦT value was 0.72. The complex showed reasonably long triplet lifetimes with τT 7210 μs in DMSO. The frequency and temperature dependence of the dielectric properties of ZnPc were also investigated in the frequency range of 40–105 Hz and in the temperature range of 300–440 °K. It has been observed that both dielectric constant ε′ and dielectric loss ε″ decrease with the rise in frequency as they increase with the rise in temperature. The decrease in ε′ with increasing frequency is attributed to the fact that as the frequency increases, the polarizability contribution from orientation sources decreases and finally disappears.
- Full Text:
- Date Issued: 2012
- Authors: Canlıca, Mevlüde , Altındal, Ahmet , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/243532 , vital:51161 , xlink:href="https://doi.org/10.1142/S1088424612500836"
- Description: The synthesis of ball-type dinuclear Zn(II) phthalocyanine containing four 4,4′-(9H-fluorene-9,9-diyl)diphenol substituents at the non-peripheral position is presented. The structure of the synthesized compound was characterized using elemental analyzes, and UV-vis, FT-IR, 1H NMR and mass spectroscopies. The ΦF value was 0.16 and ΦT value was 0.72. The complex showed reasonably long triplet lifetimes with τT 7210 μs in DMSO. The frequency and temperature dependence of the dielectric properties of ZnPc were also investigated in the frequency range of 40–105 Hz and in the temperature range of 300–440 °K. It has been observed that both dielectric constant ε′ and dielectric loss ε″ decrease with the rise in frequency as they increase with the rise in temperature. The decrease in ε′ with increasing frequency is attributed to the fact that as the frequency increases, the polarizability contribution from orientation sources decreases and finally disappears.
- Full Text:
- Date Issued: 2012
Parameter relationships in high-speed audio networks
- Chigwamba, Nyasha, Foss, Richard, Gurdan, Robby, Klinkradt, Bradley
- Authors: Chigwamba, Nyasha , Foss, Richard , Gurdan, Robby , Klinkradt, Bradley
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/427027 , vital:72409 , https://www.aes.org/e-lib/browse.cfm?elib=16211
- Description: When related audio control parameters are distributed in many devices in a high-speed audio network, a means for centralizing remote control and monitoring is required. Changes in one parameter may need to affect other parameters. The XFN protocol enables management of distributed parameters. This paper focuses on how to group related parameters that are physically separated and provides a corresponding implementation using the protocol. A comprehensive grouping theory is presented.
- Full Text:
- Date Issued: 2012
- Authors: Chigwamba, Nyasha , Foss, Richard , Gurdan, Robby , Klinkradt, Bradley
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/427027 , vital:72409 , https://www.aes.org/e-lib/browse.cfm?elib=16211
- Description: When related audio control parameters are distributed in many devices in a high-speed audio network, a means for centralizing remote control and monitoring is required. Changes in one parameter may need to affect other parameters. The XFN protocol enables management of distributed parameters. This paper focuses on how to group related parameters that are physically separated and provides a corresponding implementation using the protocol. A comprehensive grouping theory is presented.
- Full Text:
- Date Issued: 2012
4-Azidoaniline-based electropolymer as a building block for functionalisation of conductive surfaces
- Coates, Megan, Elamari, Hichem, Girard, Christian, Griveau, Sophie, Nyokong, Tebello, Bedioui, Fethi
- Authors: Coates, Megan , Elamari, Hichem , Girard, Christian , Griveau, Sophie , Nyokong, Tebello , Bedioui, Fethi
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/244404 , vital:51254 , xlink:href="https://doi.org/10.1016/j.jelechem.2012.01.001"
- Description: We propose in this work to compare three approaches using 4-azidoaniline combined with “click” chemistry and electrochemistry to anchor ferrocene moieties at glassy carbon surfaces. The immobilisation of a newly synthesised molecule, 4-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)aniline, through direct electropolymerisation or via in situ diazotization followed by electrografting is studied by analysing the samples by XPS and electrochemistry.
- Full Text:
- Date Issued: 2012
4-Azidoaniline-based electropolymer as a building block for functionalisation of conductive surfaces
- Authors: Coates, Megan , Elamari, Hichem , Girard, Christian , Griveau, Sophie , Nyokong, Tebello , Bedioui, Fethi
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/244404 , vital:51254 , xlink:href="https://doi.org/10.1016/j.jelechem.2012.01.001"
- Description: We propose in this work to compare three approaches using 4-azidoaniline combined with “click” chemistry and electrochemistry to anchor ferrocene moieties at glassy carbon surfaces. The immobilisation of a newly synthesised molecule, 4-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)aniline, through direct electropolymerisation or via in situ diazotization followed by electrografting is studied by analysing the samples by XPS and electrochemistry.
- Full Text:
- Date Issued: 2012
Layer by Layer Electrode Surface Functionalisation Using Carbon Nanotubes, Electrochemical Grafting of Azide‐Alkyne Functions and Click Chemistry
- Coates, Megan, Griveau, Sophie, Bedioui, Fethi, Nyokong, Tebello
- Authors: Coates, Megan , Griveau, Sophie , Bedioui, Fethi , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/243509 , vital:51159 , xlink:href="https://doi.org/10.1002/elan.201200240"
- Description: Ferrocene was covalently bonded to a layer of adsorbed single-walled carbon nanotubes on a glassy carbon electrode surface using electrochemical grafting and click chemistry. Grafting of the 4-azidobenzenediazonium salt onto the surface was accomplished by electrochemical reduction. The surface-bound azide groups, with the use of a copper(I) catalyst, were reacted with ethynylferrocene to form covalent 1,2,3-triazole bonds by click chemistry. This layer by layer construction of the electrode surface results in stable electrodes by combining good electrical conductivity and increased surface area of the nanotubes with the versatility of the Sharpless click reaction.
- Full Text:
- Date Issued: 2012
- Authors: Coates, Megan , Griveau, Sophie , Bedioui, Fethi , Nyokong, Tebello
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/243509 , vital:51159 , xlink:href="https://doi.org/10.1002/elan.201200240"
- Description: Ferrocene was covalently bonded to a layer of adsorbed single-walled carbon nanotubes on a glassy carbon electrode surface using electrochemical grafting and click chemistry. Grafting of the 4-azidobenzenediazonium salt onto the surface was accomplished by electrochemical reduction. The surface-bound azide groups, with the use of a copper(I) catalyst, were reacted with ethynylferrocene to form covalent 1,2,3-triazole bonds by click chemistry. This layer by layer construction of the electrode surface results in stable electrodes by combining good electrical conductivity and increased surface area of the nanotubes with the versatility of the Sharpless click reaction.
- Full Text:
- Date Issued: 2012
'God is my forest': Xhosa cultural values provide untapped opportunities for conservation
- Cocks, Michelle L, Dold, Anthony P, Vetter, Susan M
- Authors: Cocks, Michelle L , Dold, Anthony P , Vetter, Susan M
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141198 , vital:37952 , DOI: 10.4102/sajs.v108i5/6.880
- Description: In South Africa conservation is still largely framed in terms of Western scientific values, with a focus on material benefits to local communities, whilst little is known about the intangible values local people attach to nature and biodiversity. We explored the cultural, spiritual and emotional relationships with nature expressed by Xhosa people, within the MaputalandPondoland-Albany Hotspot, as well as the activities that mediate this relationship. A descriptive research approach was applied to document the emotions, meanings and values associated with landscape elements. This approach included group and individual interviews and ‘walk-in-the-woods’ interviews and participatory mapping exercises. Respondents portrayed a strong, although not always easily articulated, appreciation for nature, especially ihlathi lesiXhosa (‘Xhosa forest’, vegetation types within the Thicket Biome).
- Full Text:
- Date Issued: 2012
- Authors: Cocks, Michelle L , Dold, Anthony P , Vetter, Susan M
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141198 , vital:37952 , DOI: 10.4102/sajs.v108i5/6.880
- Description: In South Africa conservation is still largely framed in terms of Western scientific values, with a focus on material benefits to local communities, whilst little is known about the intangible values local people attach to nature and biodiversity. We explored the cultural, spiritual and emotional relationships with nature expressed by Xhosa people, within the MaputalandPondoland-Albany Hotspot, as well as the activities that mediate this relationship. A descriptive research approach was applied to document the emotions, meanings and values associated with landscape elements. This approach included group and individual interviews and ‘walk-in-the-woods’ interviews and participatory mapping exercises. Respondents portrayed a strong, although not always easily articulated, appreciation for nature, especially ihlathi lesiXhosa (‘Xhosa forest’, vegetation types within the Thicket Biome).
- Full Text:
- Date Issued: 2012
A new broom sweeps clean: the economic and cultural value of grass brooms in the Eastern Cape Province, South Africa
- Cocks, Michelle L, Dold, Anthony P
- Authors: Cocks, Michelle L , Dold, Anthony P
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141382 , vital:37967 , DOI: 10.1080/14728028.2004.9752477
- Description: In southern Africa over the last twenty years, much attention has been given to the importance of NTFPs for rural livelihoods through their household consumption and sale. They have been classified as having either subsistence consumption or commercial values. These values are mostly related to their utilitarian functions, but recent studies show that NTFPs also hold strong cultural functions. Such cultural functions can play a role in both rural and urban livelihoods; consequently the values of NTFPs may be related to both utilitarian and cultural functions. This paper demonstrates the cultural functions of grass brooms in urban areas in South Africa and the impact of their trade on income generation in rural areas, and discusses the concept of culture as a significant factor in the understanding of the role of NTFPs in livelihoods, and their values.
- Full Text:
- Date Issued: 2012
- Authors: Cocks, Michelle L , Dold, Anthony P
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/141382 , vital:37967 , DOI: 10.1080/14728028.2004.9752477
- Description: In southern Africa over the last twenty years, much attention has been given to the importance of NTFPs for rural livelihoods through their household consumption and sale. They have been classified as having either subsistence consumption or commercial values. These values are mostly related to their utilitarian functions, but recent studies show that NTFPs also hold strong cultural functions. Such cultural functions can play a role in both rural and urban livelihoods; consequently the values of NTFPs may be related to both utilitarian and cultural functions. This paper demonstrates the cultural functions of grass brooms in urban areas in South Africa and the impact of their trade on income generation in rural areas, and discusses the concept of culture as a significant factor in the understanding of the role of NTFPs in livelihoods, and their values.
- Full Text:
- Date Issued: 2012
Perceptions and values of local landscapes: implications for the conservation of biocultural diversity and intangible heritage
- Cocks, Michelle L, Dold, Anthony P
- Authors: Cocks, Michelle L , Dold, Anthony P
- Date: 2012
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/141442 , vital:37972 , ISBN 9789086867493 , DOI: 10.3920/978-90-8686-749-3_10
- Description: South Africa is widely recognised as a highly diverse country with regard to its people, culture, landscapes, biological resources and ecology. The importance of policies on protecting cultural diversity and how they relate to the environment is only just emerging at an international level, but in South African we find there is a complete lack of institutional support for rural communities’ attachment to local landscapes. The main objective of this case study is to improve our understanding of the meanings and values that Xhosa people (amaXhosa) of the Eastern Cape Province of South Africa attach to their natural landscapes. It is clear that the amaXhosa are still intrinsically connected to their natural environment, in particular the thicket biome that is called ihlathi yesiXhosa (Xhosa forest). Access to places and spaces within the natural environment provides a sense of wellbeing, a link to ancestral spirits, a location for religious rituals, plus a wealth of culturallyinspired uses of specific species and sacred places in the landscape. We suggest that local cultural values could be incorporated into the formal conservation process.
- Full Text:
- Date Issued: 2012
- Authors: Cocks, Michelle L , Dold, Anthony P
- Date: 2012
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/141442 , vital:37972 , ISBN 9789086867493 , DOI: 10.3920/978-90-8686-749-3_10
- Description: South Africa is widely recognised as a highly diverse country with regard to its people, culture, landscapes, biological resources and ecology. The importance of policies on protecting cultural diversity and how they relate to the environment is only just emerging at an international level, but in South African we find there is a complete lack of institutional support for rural communities’ attachment to local landscapes. The main objective of this case study is to improve our understanding of the meanings and values that Xhosa people (amaXhosa) of the Eastern Cape Province of South Africa attach to their natural landscapes. It is clear that the amaXhosa are still intrinsically connected to their natural environment, in particular the thicket biome that is called ihlathi yesiXhosa (Xhosa forest). Access to places and spaces within the natural environment provides a sense of wellbeing, a link to ancestral spirits, a location for religious rituals, plus a wealth of culturallyinspired uses of specific species and sacred places in the landscape. We suggest that local cultural values could be incorporated into the formal conservation process.
- Full Text:
- Date Issued: 2012
Maternity Protection: discussion document 27-29 March 2012
- Congress of South African Trade Unions (COSATU)
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Uncatalogued
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68729 , vital:29309
- Description: Developed with the support of Solidarity Center (AFL-CIO) South Africa We would like to thank the COSATU Affiliates and Provinces for their contribution towards the development of this booklet. Special appreciation goes to the members of the COSATU National Gender Coordinating Committee (NGCC) and National Office Bearers designated to gender for their unwavering support towards the production of this booklet. Also our special gratitude goes to the following organisations who contributed towards compiling and development of the booklet:- • Commission for Gender Equality (CGE) • Gina Barbieri Attorneys • Legal Resource Centre(LRC) • African Diaspora Women Workers Network(ADWWN) • South African Self Employed Women’s Association(SASEWA) • International Labour Organisation (ILO).
- Full Text:
- Date Issued: 2012
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Uncatalogued
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68729 , vital:29309
- Description: Developed with the support of Solidarity Center (AFL-CIO) South Africa We would like to thank the COSATU Affiliates and Provinces for their contribution towards the development of this booklet. Special appreciation goes to the members of the COSATU National Gender Coordinating Committee (NGCC) and National Office Bearers designated to gender for their unwavering support towards the production of this booklet. Also our special gratitude goes to the following organisations who contributed towards compiling and development of the booklet:- • Commission for Gender Equality (CGE) • Gina Barbieri Attorneys • Legal Resource Centre(LRC) • African Diaspora Women Workers Network(ADWWN) • South African Self Employed Women’s Association(SASEWA) • International Labour Organisation (ILO).
- Full Text:
- Date Issued: 2012
Domestic workers: discussion document 27-29 March 2012
- Congress of South African Trade Unions (COSATU)
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Labor unions South Africa , Household employees South Africa , Cosatu
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68711 , vital:29307
- Description: The 5th Cosatu Congress resolved that a research be commissioned by the CEC and conducted by Naledi on the need for establishment of advice centres for servicing and assisting domestic workers. Again, part of the resolution indicated that we should consider finding a viable home for domestic workers. As we move towards the 11th Cosatu Gender Conference, we need to reflect and take stock of the previous resolutions passed on domestic workers, assess the strategies/ steps taken for implementation and make a way forward. This paper has arisen as a follow-up of the afore-mentioned resolution including the commitment made by Cosatu on the Summit held between 27-28 August 2011 which the federation hosted in partnership with the South African Domestic Services and Allied Workers Union (SADSAWU) and the South African Office of the ILO. The aim is to stimulate and resuscitate discussions on domestic work acknowledging the positive steps taken at international level of adoption of ILO Convention 189 (C189) on Decent Work for Domestic Workers and its Recommendation 201 (R201).
- Full Text:
- Date Issued: 2012
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Labor unions South Africa , Household employees South Africa , Cosatu
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68711 , vital:29307
- Description: The 5th Cosatu Congress resolved that a research be commissioned by the CEC and conducted by Naledi on the need for establishment of advice centres for servicing and assisting domestic workers. Again, part of the resolution indicated that we should consider finding a viable home for domestic workers. As we move towards the 11th Cosatu Gender Conference, we need to reflect and take stock of the previous resolutions passed on domestic workers, assess the strategies/ steps taken for implementation and make a way forward. This paper has arisen as a follow-up of the afore-mentioned resolution including the commitment made by Cosatu on the Summit held between 27-28 August 2011 which the federation hosted in partnership with the South African Domestic Services and Allied Workers Union (SADSAWU) and the South African Office of the ILO. The aim is to stimulate and resuscitate discussions on domestic work acknowledging the positive steps taken at international level of adoption of ILO Convention 189 (C189) on Decent Work for Domestic Workers and its Recommendation 201 (R201).
- Full Text:
- Date Issued: 2012
Gender Policy: discussion document 27-29 March 2012
- Congress of South African Trade Unions (COSATU)
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Uncatalogued
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68759 , vital:29312
- Description: The Gender policy draws together existing COSATU resolutions into a coherent document, while further enriching these resolutions. This document aims to combine the vision and principles that we aspire towards, with practical relations in the working workplace and economy, in trade unions and in broader society. The issue of gender equality has been on our agenda since the formation of COSATU. However, we require a policy framework to guide our struggles to transform gender relations in the current period. It is therefore important that we reflect on progress in taking forward the vision and programmes adopted on several Congresses since COSATU inception. In broad terms, progress to realise these resolutions has been uneven and varies between affiliates. COSATU and its affiliates are guided by a vision of a society free of sexism, racism, class exploitation, and other forms of oppression. We envisage a future where women participate equally in the economy and society without barriers, and where women are emancipated from all forms of oppression in the household, the workplace and in broader society. We have a vision of a trade union movement as a home for women workers. This policy document was debated and adopted and the National Gender Conference (held on 5-7 July 2000). It is tabled at Congress for discussion and adoption. Once it has been adopted by the Congress all affiliates will have to give expression to this broad framework in their own policies.
- Full Text:
- Date Issued: 2012
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Uncatalogued
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68759 , vital:29312
- Description: The Gender policy draws together existing COSATU resolutions into a coherent document, while further enriching these resolutions. This document aims to combine the vision and principles that we aspire towards, with practical relations in the working workplace and economy, in trade unions and in broader society. The issue of gender equality has been on our agenda since the formation of COSATU. However, we require a policy framework to guide our struggles to transform gender relations in the current period. It is therefore important that we reflect on progress in taking forward the vision and programmes adopted on several Congresses since COSATU inception. In broad terms, progress to realise these resolutions has been uneven and varies between affiliates. COSATU and its affiliates are guided by a vision of a society free of sexism, racism, class exploitation, and other forms of oppression. We envisage a future where women participate equally in the economy and society without barriers, and where women are emancipated from all forms of oppression in the household, the workplace and in broader society. We have a vision of a trade union movement as a home for women workers. This policy document was debated and adopted and the National Gender Conference (held on 5-7 July 2000). It is tabled at Congress for discussion and adoption. Once it has been adopted by the Congress all affiliates will have to give expression to this broad framework in their own policies.
- Full Text:
- Date Issued: 2012
Sex work: discussion document 27-29 March 2012
- Congress of South African Trade Unions (COSATU)
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Uncatalogued
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68748 , vital:29311
- Description: The aim of this paper is to resuscitate the debate on the need for decriminalization of sex work and ensure that COSATU and its affiliates further engage within structures, alliance, non -governmental organizations and with the Government in terms of the need for law reform and identify alternative policy framework. However, whatever outcome of the legal processes pertaining to sex work, should be abide by the spirit of the Constitution which is committed to advancing human rights and social justice. Sex work in South Africa is currently criminalised and is restricted by the Sexual Offences Act of 1957 (an un-amended apartheid-era law) which prohibits all activities associated with it. The criminal offences related to sex work include amongst them the keeping or participating in the management of a brothel, procuring someone to become a sex worker, soliciting or selling sex or living of the earnings of a sex worker. In 2007 through the Sexual Offences Act their clients were also criminalised In 2007, the Act was amended to criminalise buyers of sexual services too (SALRC 2009). We therefore argue that the existing laws on sex work are nothing but hypocrisy of the conservatives and elites. They do not improve the conditions of women; instead they worsen the miserable conditions that women in the sex trade already find themselves in. The missing fact is that sex work is a by-product of our patriarchal capitalist society-not something created by some “immoral prostitute” The current oppressive legislation on sex work has stimulated a lot of debates and has led to an upsurge in advocacy work by individuals and organizations around the need to either legalise or decriminalize sex work. Likewise, Cosatu as a key civil society player has also played a leading role in its endeavor to unite the working class and to defend workers from exploitation as well as finding workable solutions to the plight of the most vulnerable people in our society who find themselves with no choice but to engage in sex work. The sex industry is by nature exploitative and inherently dangerous. Women in the industry experience different degrees of abuse, coercion and violence, but all of them are harmed physically and psychologically. As a trade union movement, COSATU has an interest in the debate about sex work, from the point of view that sex work targets mainly the working class and the poor, predominantly black women. High levels of unemployment, poverty and gender inequality are key factors driving sex work. The global economic crisis has aggravated the situation for the poor majority through job losses, casualisation and ultimately increased feminization of poverty. Cosatu has already started some debates and campaigns aimed at devising ways of protecting sex workers through collective workers struggles. As such, the sex work discourse and campaign among Cosatu affiliates for decriminalization was tabled at the Federation’s 10th Congress though it was deferred because of contestation and opposition amongst delegates. However, affiliates had the responsibility to go back and make further consultations, sensitization with their structures and open up a discussion at the level of the COSATU Central Executive Committee. Indeed, it is high time that the debate on decriminalization should be concluded and that sex work be recognized as work as Arnott and Crago (2009) argue that: “The criminalisation of sex work has precluded the enforcement and protection of sex workers’ Labour rights. This disregard for sex workers as workers has left many of those employed in brothels in South Africa vulnerable to labor abuses such as withheld wages, arbitrary fines, restrictions on mobility, and confiscation of belongings including medication. Sex workers on the street or working in brothels and other agencies have no recourse if customers refuse to pay them’’1 The decriminalization of sex work should take the course of a rights- based approach which means that sex workers would be able to enjoy their basic human & labour rights and be protected against sexual harassment, violence, rape and unfair working conditions. By so doing, sex workers would be able to access non-discriminatory health care services, be more empowered and operate within the ambit of protective labour and occupational health & safety laws.
- Full Text:
- Date Issued: 2012
- Authors: Congress of South African Trade Unions (COSATU)
- Date: 2012
- Subjects: Uncatalogued
- Language: English
- Type: book , text
- Identifier: http://hdl.handle.net/10962/68748 , vital:29311
- Description: The aim of this paper is to resuscitate the debate on the need for decriminalization of sex work and ensure that COSATU and its affiliates further engage within structures, alliance, non -governmental organizations and with the Government in terms of the need for law reform and identify alternative policy framework. However, whatever outcome of the legal processes pertaining to sex work, should be abide by the spirit of the Constitution which is committed to advancing human rights and social justice. Sex work in South Africa is currently criminalised and is restricted by the Sexual Offences Act of 1957 (an un-amended apartheid-era law) which prohibits all activities associated with it. The criminal offences related to sex work include amongst them the keeping or participating in the management of a brothel, procuring someone to become a sex worker, soliciting or selling sex or living of the earnings of a sex worker. In 2007 through the Sexual Offences Act their clients were also criminalised In 2007, the Act was amended to criminalise buyers of sexual services too (SALRC 2009). We therefore argue that the existing laws on sex work are nothing but hypocrisy of the conservatives and elites. They do not improve the conditions of women; instead they worsen the miserable conditions that women in the sex trade already find themselves in. The missing fact is that sex work is a by-product of our patriarchal capitalist society-not something created by some “immoral prostitute” The current oppressive legislation on sex work has stimulated a lot of debates and has led to an upsurge in advocacy work by individuals and organizations around the need to either legalise or decriminalize sex work. Likewise, Cosatu as a key civil society player has also played a leading role in its endeavor to unite the working class and to defend workers from exploitation as well as finding workable solutions to the plight of the most vulnerable people in our society who find themselves with no choice but to engage in sex work. The sex industry is by nature exploitative and inherently dangerous. Women in the industry experience different degrees of abuse, coercion and violence, but all of them are harmed physically and psychologically. As a trade union movement, COSATU has an interest in the debate about sex work, from the point of view that sex work targets mainly the working class and the poor, predominantly black women. High levels of unemployment, poverty and gender inequality are key factors driving sex work. The global economic crisis has aggravated the situation for the poor majority through job losses, casualisation and ultimately increased feminization of poverty. Cosatu has already started some debates and campaigns aimed at devising ways of protecting sex workers through collective workers struggles. As such, the sex work discourse and campaign among Cosatu affiliates for decriminalization was tabled at the Federation’s 10th Congress though it was deferred because of contestation and opposition amongst delegates. However, affiliates had the responsibility to go back and make further consultations, sensitization with their structures and open up a discussion at the level of the COSATU Central Executive Committee. Indeed, it is high time that the debate on decriminalization should be concluded and that sex work be recognized as work as Arnott and Crago (2009) argue that: “The criminalisation of sex work has precluded the enforcement and protection of sex workers’ Labour rights. This disregard for sex workers as workers has left many of those employed in brothels in South Africa vulnerable to labor abuses such as withheld wages, arbitrary fines, restrictions on mobility, and confiscation of belongings including medication. Sex workers on the street or working in brothels and other agencies have no recourse if customers refuse to pay them’’1 The decriminalization of sex work should take the course of a rights- based approach which means that sex workers would be able to enjoy their basic human & labour rights and be protected against sexual harassment, violence, rape and unfair working conditions. By so doing, sex workers would be able to access non-discriminatory health care services, be more empowered and operate within the ambit of protective labour and occupational health & safety laws.
- Full Text:
- Date Issued: 2012
The direct use value of municipal commonage goods and services to urban households in the Eastern Cape, South Africa
- Davenport, Nicholas A, Shackleton, Charlie M, Gambiza, James
- Authors: Davenport, Nicholas A , Shackleton, Charlie M , Gambiza, James
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/181071 , vital:43696 , xlink:href="https://doi.org/10.1016/j.landusepol.2011.09.008"
- Description: To redress past racial discrepancies in ownership and tenure, the ANC government of South Africa initiated programmes to make land accessible to the previously disadvantaged. A key component of the national land reform programme was the provision of commonage lands to urban municipalities for use by the urban poor. However, there has been no assessment of the contribution that urban commonage makes to previously disadvantaged households. This study assessed the economic benefits of the commonage programme to local households, through an in-depth survey of 90 households across three small towns in the Eastern Cape of South Africa. We examined the marketed and non-marketed consumptive direct-use values of land-based livelihoods on commonage, calculated via the ‘own reported values’ approach. The results indicate that a proportion of South Africa's urban population rely to some degree on municipal commonage for part of their livelihoods. Commonage contributions to total livelihood incomes ranged between 14 and 20%. If the contributions from commonage were excluded, the incomes of over 10% of households in each study town would drop below the poverty line. Overall, the value of harvests from commonage was worth over R1 000 (US$ 142) per hectare per year and over R4.7 million (US$ 0.68 million) per commonage per year. However, the extent and nature of use and reliance was not uniform among households, so that we developed a typology of commonage users, with four types being identified. However, rapidly growing urban populations and high levels of poverty potentially threaten the sustainability of commonage resource use. Yet the national land reform programme focuses largely on the transfer of land to municipalities and not on sustainable management. Municipalities, in turn, invest relatively little in commonage management, and the little they do is focussed on livestock production. Non-timber forest products are not considered at all, even though this study shows that they are a vital resource for the urban poor, notably for energy and construction materials.
- Full Text:
- Date Issued: 2012
- Authors: Davenport, Nicholas A , Shackleton, Charlie M , Gambiza, James
- Date: 2012
- Subjects: To be catalogued
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/181071 , vital:43696 , xlink:href="https://doi.org/10.1016/j.landusepol.2011.09.008"
- Description: To redress past racial discrepancies in ownership and tenure, the ANC government of South Africa initiated programmes to make land accessible to the previously disadvantaged. A key component of the national land reform programme was the provision of commonage lands to urban municipalities for use by the urban poor. However, there has been no assessment of the contribution that urban commonage makes to previously disadvantaged households. This study assessed the economic benefits of the commonage programme to local households, through an in-depth survey of 90 households across three small towns in the Eastern Cape of South Africa. We examined the marketed and non-marketed consumptive direct-use values of land-based livelihoods on commonage, calculated via the ‘own reported values’ approach. The results indicate that a proportion of South Africa's urban population rely to some degree on municipal commonage for part of their livelihoods. Commonage contributions to total livelihood incomes ranged between 14 and 20%. If the contributions from commonage were excluded, the incomes of over 10% of households in each study town would drop below the poverty line. Overall, the value of harvests from commonage was worth over R1 000 (US$ 142) per hectare per year and over R4.7 million (US$ 0.68 million) per commonage per year. However, the extent and nature of use and reliance was not uniform among households, so that we developed a typology of commonage users, with four types being identified. However, rapidly growing urban populations and high levels of poverty potentially threaten the sustainability of commonage resource use. Yet the national land reform programme focuses largely on the transfer of land to municipalities and not on sustainable management. Municipalities, in turn, invest relatively little in commonage management, and the little they do is focussed on livestock production. Non-timber forest products are not considered at all, even though this study shows that they are a vital resource for the urban poor, notably for energy and construction materials.
- Full Text:
- Date Issued: 2012
Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro:
- de la Mare, Jo-Anne, Lawson, Jessica C, Chiwakata, Maynard T, Beukes, Denzil R, Blatch, Gregory L, Edkins, Adrienne L
- Authors: de la Mare, Jo-Anne , Lawson, Jessica C , Chiwakata, Maynard T , Beukes, Denzil R , Blatch, Gregory L , Edkins, Adrienne L
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165165 , vital:41214 , DOI: 10.1007/s10637-011-9788-0
- Description: Red and brown algae have been shown to produce a variety of compounds with chemotherapeutic potential. A recent report described the isolation of a range of novel polyhalogenated monoterpene compounds from the red algae Plocamium corallorhiza and Plocamium cornutum collected off the coast of South Africa, together with the previously described tetraprenylquinone, sargaquinoic acid (SQA), from the brown algae Sargassum heterophyllum. In our study, the algal compounds were screened for anti-proliferative activity against metastatic MDA-MB-231 breast cancer cells revealing that a number of compounds displayed anti-cancer activity with IC50 values in the micromolar range. A subset of the compounds was tested for differential toxicity in the MCF-7/MCF12A system and five of these, including sargaquinoic acid, were found to be at least three times more toxic to the breast cancer than the non-malignant cell line.
- Full Text:
- Date Issued: 2012
- Authors: de la Mare, Jo-Anne , Lawson, Jessica C , Chiwakata, Maynard T , Beukes, Denzil R , Blatch, Gregory L , Edkins, Adrienne L
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/165165 , vital:41214 , DOI: 10.1007/s10637-011-9788-0
- Description: Red and brown algae have been shown to produce a variety of compounds with chemotherapeutic potential. A recent report described the isolation of a range of novel polyhalogenated monoterpene compounds from the red algae Plocamium corallorhiza and Plocamium cornutum collected off the coast of South Africa, together with the previously described tetraprenylquinone, sargaquinoic acid (SQA), from the brown algae Sargassum heterophyllum. In our study, the algal compounds were screened for anti-proliferative activity against metastatic MDA-MB-231 breast cancer cells revealing that a number of compounds displayed anti-cancer activity with IC50 values in the micromolar range. A subset of the compounds was tested for differential toxicity in the MCF-7/MCF12A system and five of these, including sargaquinoic acid, were found to be at least three times more toxic to the breast cancer than the non-malignant cell line.
- Full Text:
- Date Issued: 2012
Long-term catch and effort trends in Eastern Cape Angling Week competitions
- Dicken, Matthew L, Smale, Malcolm J, Booth, Anthony J
- Authors: Dicken, Matthew L , Smale, Malcolm J , Booth, Anthony J
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124931 , vital:35711 , https://doi.org/10.2989/1814232X.2012.709961
- Description: Recreational shore-based angling is one of the most popular sport and outdoor activity pastimes in South Africa with an estimated 412 000 fishers (McGrath et al. 1997). It is a form of linefishing where fish are caught using a hook and line and comprises a social as well as a more formal organized competitive sector (van der Elst 1989). Similar to other components of the linefishery, which include the subsistence as well as boat-based commercial sectors, excessive shore-fishing effort along the Eastern Cape has resulted not only in declining catches (Bennett 1991, Griffiths 1997, Brouwer and Buxton 2002, Pradervand and Govender 2003) but also changes in the species composition of catches (Bennett et al. 1994, Brouwer et al. 1997, Attwood and Farquhar 1999). Stock assessments indicate that many important linefish species are severely overexploited (Griffiths 1997, Hutchings 2000, Mann 2000) and that continued fishing pressure threatens endemic linefish populations. In 1996, shore-anglers alone were responsible for an annual catch of approximately 4.5 million fish, weighing around 3 000 tonnes (Brouwer et al. 1997).
- Full Text:
- Date Issued: 2012
- Authors: Dicken, Matthew L , Smale, Malcolm J , Booth, Anthony J
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/124931 , vital:35711 , https://doi.org/10.2989/1814232X.2012.709961
- Description: Recreational shore-based angling is one of the most popular sport and outdoor activity pastimes in South Africa with an estimated 412 000 fishers (McGrath et al. 1997). It is a form of linefishing where fish are caught using a hook and line and comprises a social as well as a more formal organized competitive sector (van der Elst 1989). Similar to other components of the linefishery, which include the subsistence as well as boat-based commercial sectors, excessive shore-fishing effort along the Eastern Cape has resulted not only in declining catches (Bennett 1991, Griffiths 1997, Brouwer and Buxton 2002, Pradervand and Govender 2003) but also changes in the species composition of catches (Bennett et al. 1994, Brouwer et al. 1997, Attwood and Farquhar 1999). Stock assessments indicate that many important linefish species are severely overexploited (Griffiths 1997, Hutchings 2000, Mann 2000) and that continued fishing pressure threatens endemic linefish populations. In 1996, shore-anglers alone were responsible for an annual catch of approximately 4.5 million fish, weighing around 3 000 tonnes (Brouwer et al. 1997).
- Full Text:
- Date Issued: 2012
The economics of greening the Grahamstown National Arts Festival in South Africa
- Dobson, Blaise, Snowball, Jeanette D
- Authors: Dobson, Blaise , Snowball, Jeanette D
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/71445 , vital:29851 , https://hdl.handle.net/10520/EJC132010
- Description: The article analyses the broad history underpinning the notion of sustainable development and its context within the events industry in South Africa. It explores the willingness of festival-goers to pay for a hypothetical recycling programme to reduce the negative externalities of the Festival. Results show that festival-goers were, on average, willing to pay an additional R2.30 per "green" ticket to fund the proposed programme. A statistical regression was used to explore the determinants of willing-to-pay. If applied to all tickets, the total willing-to-pay amount far exceeded the actual cost of the recycling programme.
- Full Text: false
- Date Issued: 2012
- Authors: Dobson, Blaise , Snowball, Jeanette D
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/71445 , vital:29851 , https://hdl.handle.net/10520/EJC132010
- Description: The article analyses the broad history underpinning the notion of sustainable development and its context within the events industry in South Africa. It explores the willingness of festival-goers to pay for a hypothetical recycling programme to reduce the negative externalities of the Festival. Results show that festival-goers were, on average, willing to pay an additional R2.30 per "green" ticket to fund the proposed programme. A statistical regression was used to explore the determinants of willing-to-pay. If applied to all tickets, the total willing-to-pay amount far exceeded the actual cost of the recycling programme.
- Full Text: false
- Date Issued: 2012
Voices from the forest: celebrating nature and culture in Xhosaland
- Dold, Anthony P, Cocks, Michelle L
- Authors: Dold, Anthony P , Cocks, Michelle L
- Date: 2012
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/141427 , vital:37971 , ISBN 9781431402991 , https://www.amazon.com/Voices-Forest-Celebrating-Culture-Xhosaland/dp/1431402990
- Description: The link between people and nature is explored in this fascinating book, revealing how plants, animals, and landscapes are profoundly reflected in South Africa’s Xhosa language, stories, poetry, religious rituals, healing practices, and everyday customs. While the South African landscape has for centuries been molded and manipulated by humans, the country and its plants and animals have in turn influenced South Africans’ cultural and spiritual development. Based on 10 years of research, it consists of unique photographs that portray how both contemporary rural and urban South Africans still find great value in nature. A fresh, positive approach to biodiversity conservation, this volume serves as a guide to sustainable practices in the future.
- Full Text:
- Date Issued: 2012
- Authors: Dold, Anthony P , Cocks, Michelle L
- Date: 2012
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/141427 , vital:37971 , ISBN 9781431402991 , https://www.amazon.com/Voices-Forest-Celebrating-Culture-Xhosaland/dp/1431402990
- Description: The link between people and nature is explored in this fascinating book, revealing how plants, animals, and landscapes are profoundly reflected in South Africa’s Xhosa language, stories, poetry, religious rituals, healing practices, and everyday customs. While the South African landscape has for centuries been molded and manipulated by humans, the country and its plants and animals have in turn influenced South Africans’ cultural and spiritual development. Based on 10 years of research, it consists of unique photographs that portray how both contemporary rural and urban South Africans still find great value in nature. A fresh, positive approach to biodiversity conservation, this volume serves as a guide to sustainable practices in the future.
- Full Text:
- Date Issued: 2012
Service discovery using open sound control
- Eales, Andrew, Foss, Richard
- Authors: Eales, Andrew , Foss, Richard
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/426890 , vital:72398 , https://www.aes.org/e-lib/online/browse.cfm?elib=16432
- Description: The Open Sound Control (OSC) control protocol does not have service discovery capabilities. The approach to adding service discovery to OSC proposed in this paper uses the OSC address space to represent services within the context of a logical device model. This model allows services to be represented in a context-sensitive manner by relating parameters representing services to the logical organization of a device. Implementation of service discovery is done using standard OSC messages and requires that the OSC address space be designed to support these messages. This paper illustrates how these enhancements to OSC allow a device to advertise its services. Controller applications can then explore the device’s address space to discover services and retrieve the services required by the application. The Open Sound Control (OSC) control protocol does not have service discovery capabilities. The approach to adding service discovery to OSC proposed in this paper uses the OSC address space to represent services within the context of a logical device model. This model allows services to be represented in a context-sensitive manner by relating parameters representing services to the logical organization of a device. Implementation of service discovery is done using standard OSC messages and requires that the OSC address space be designed to support these messages. This paper illustrates how these enhancements to OSC allow a device to advertise its services. Controller applications can then explore the device’s address space to discover services and retrieve the services required by the application.
- Full Text:
- Date Issued: 2012
- Authors: Eales, Andrew , Foss, Richard
- Date: 2012
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/426890 , vital:72398 , https://www.aes.org/e-lib/online/browse.cfm?elib=16432
- Description: The Open Sound Control (OSC) control protocol does not have service discovery capabilities. The approach to adding service discovery to OSC proposed in this paper uses the OSC address space to represent services within the context of a logical device model. This model allows services to be represented in a context-sensitive manner by relating parameters representing services to the logical organization of a device. Implementation of service discovery is done using standard OSC messages and requires that the OSC address space be designed to support these messages. This paper illustrates how these enhancements to OSC allow a device to advertise its services. Controller applications can then explore the device’s address space to discover services and retrieve the services required by the application. The Open Sound Control (OSC) control protocol does not have service discovery capabilities. The approach to adding service discovery to OSC proposed in this paper uses the OSC address space to represent services within the context of a logical device model. This model allows services to be represented in a context-sensitive manner by relating parameters representing services to the logical organization of a device. Implementation of service discovery is done using standard OSC messages and requires that the OSC address space be designed to support these messages. This paper illustrates how these enhancements to OSC allow a device to advertise its services. Controller applications can then explore the device’s address space to discover services and retrieve the services required by the application.
- Full Text:
- Date Issued: 2012
Targeting conserved pathways as a strategy for novel drug development: disabling the cellular stress response:
- Edkins, Adrienne L, Blatch, Gregory L
- Authors: Edkins, Adrienne L , Blatch, Gregory L
- Date: 2012
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/165129 , vital:41211 , ISBN 978-3-642-28174-7 , DOI: 10.1007/978-3-642-28175-4_4
- Description: The ability to respond to and cope with stress at a molecular level is essential for cell survival. The stress response is conserved across organisms by the expression of a group of molecular chaperones known as heat shock proteins (HSP). HSP are ubiquitous and highly conserved proteins that regulate cellular protein homeostasis and trafficking under physiological and stressful conditions, including diseases such as cancer and malaria. HSP are good drug targets for the treatment of human diseases, as the significant functional and structural data available suggest that they are essential for cell survival and that, despite conservation across species, there are biophysical and biochemical differences between HSP in normal and disease states that allow HSP to be selectively targeted. In this chapter, we review the international status of this area of research and highlight progress by us and other African researchers towards the characterisation and targeting of HSP from humans and parasites from Plasmodium and Trypanosoma as drug targets.
- Full Text:
- Date Issued: 2012
- Authors: Edkins, Adrienne L , Blatch, Gregory L
- Date: 2012
- Language: English
- Type: text , book
- Identifier: http://hdl.handle.net/10962/165129 , vital:41211 , ISBN 978-3-642-28174-7 , DOI: 10.1007/978-3-642-28175-4_4
- Description: The ability to respond to and cope with stress at a molecular level is essential for cell survival. The stress response is conserved across organisms by the expression of a group of molecular chaperones known as heat shock proteins (HSP). HSP are ubiquitous and highly conserved proteins that regulate cellular protein homeostasis and trafficking under physiological and stressful conditions, including diseases such as cancer and malaria. HSP are good drug targets for the treatment of human diseases, as the significant functional and structural data available suggest that they are essential for cell survival and that, despite conservation across species, there are biophysical and biochemical differences between HSP in normal and disease states that allow HSP to be selectively targeted. In this chapter, we review the international status of this area of research and highlight progress by us and other African researchers towards the characterisation and targeting of HSP from humans and parasites from Plasmodium and Trypanosoma as drug targets.
- Full Text:
- Date Issued: 2012