Overcoming supply line barriers to the implementation of lean manufacturing in the Transwerk Uitenhage Plant
- Authors: Madwara, Nomonde Juliet
- Date: 2006
- Subjects: Production management -- South Africa -- Uitenhage
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8621 , http://hdl.handle.net/10948/552 , Production management -- South Africa -- Uitenhage
- Description: The objective of this study is to assess the Lean Manufacturing practices by Transwerk Uitenhage and to reveal the barriers to implementation of lean manufacturing strategies experienced by their supply line. This will be compared to what the literature says and suggestions to overcome these barriers will be developed.
- Full Text:
- Date Issued: 2006
- Authors: Madwara, Nomonde Juliet
- Date: 2006
- Subjects: Production management -- South Africa -- Uitenhage
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:8621 , http://hdl.handle.net/10948/552 , Production management -- South Africa -- Uitenhage
- Description: The objective of this study is to assess the Lean Manufacturing practices by Transwerk Uitenhage and to reveal the barriers to implementation of lean manufacturing strategies experienced by their supply line. This will be compared to what the literature says and suggestions to overcome these barriers will be developed.
- Full Text:
- Date Issued: 2006
The playing characteristics of American trombones and German-system bassoons
- Authors: Galloway, David John
- Date: 1985
- Subjects: Trombone Bassoon
- Language: English
- Type: Thesis , Masters , MMus
- Identifier: vital:2661 , http://hdl.handle.net/10962/d1004508
- Description: Preface: South Africa, a country renowned for its mineral wealth has, perhaps manufacturing paradoxically, no musical wind instrument industry of its own as yet. Thus performers, educators and students alike have either to travel to Europe or America to select an instrument, or to import an expensive instrument that may be both unseen and untried, as very few musical instrument dealers are prepared to outlay capital on stock which appeals to a decided minority of their potential customers. Alternately, a purchase of a particular make or model can be made on the basis of a hearsay opinion; at best, the opportunity for first-hand assessment is minimal. It is the trombone of U. S.A. manufacture and the German bassoon which represent the current state of their respective manufacturing arts, and the yardsticks by which their many imitator's efforts are measured. One of the main aims of this Thesis is to describe in objective terms what has been experienced subjectively over the years of involvement with these instruments -- arguably a task similar to that of the art critic, but operating within more positively defined parameters namely, what works for the student and professional. , and what doesn't. The candidate claims credit for introducing the large-bore Bb/F trombone to South Africa in 1961, following with the introduction of the ·first double-valve bass trombone in 1965, and the first in 1979. The first Schreiber bassoons The advantages and trombone and other bassoon and other such instrument with in-line rotors of the new 5000 series larger-bore was likewise introduced in 1981. pitfalls of " doubling" between the wind instruments , and between the winds, are disc ussed at length in the final section of the Thesis.
- Full Text:
- Date Issued: 1985
- Authors: Galloway, David John
- Date: 1985
- Subjects: Trombone Bassoon
- Language: English
- Type: Thesis , Masters , MMus
- Identifier: vital:2661 , http://hdl.handle.net/10962/d1004508
- Description: Preface: South Africa, a country renowned for its mineral wealth has, perhaps manufacturing paradoxically, no musical wind instrument industry of its own as yet. Thus performers, educators and students alike have either to travel to Europe or America to select an instrument, or to import an expensive instrument that may be both unseen and untried, as very few musical instrument dealers are prepared to outlay capital on stock which appeals to a decided minority of their potential customers. Alternately, a purchase of a particular make or model can be made on the basis of a hearsay opinion; at best, the opportunity for first-hand assessment is minimal. It is the trombone of U. S.A. manufacture and the German bassoon which represent the current state of their respective manufacturing arts, and the yardsticks by which their many imitator's efforts are measured. One of the main aims of this Thesis is to describe in objective terms what has been experienced subjectively over the years of involvement with these instruments -- arguably a task similar to that of the art critic, but operating within more positively defined parameters namely, what works for the student and professional. , and what doesn't. The candidate claims credit for introducing the large-bore Bb/F trombone to South Africa in 1961, following with the introduction of the ·first double-valve bass trombone in 1965, and the first in 1979. The first Schreiber bassoons The advantages and trombone and other bassoon and other such instrument with in-line rotors of the new 5000 series larger-bore was likewise introduced in 1981. pitfalls of " doubling" between the wind instruments , and between the winds, are disc ussed at length in the final section of the Thesis.
- Full Text:
- Date Issued: 1985
The impact of smart cards on South African rural pensioners' lives
- Authors: Nyoka, Zanele
- Date: 2004
- Subjects: Old age pensioners -- South Africa -- Management Smart cards South African Post Office
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:818 , http://hdl.handle.net/10962/d1008052
- Description: E-commerce technologies have many possible applications both in commercial and non-commercial operations. The development and implementation of these applications is on the increase especially by government and its agencies, for the delivery of services. Specific to this study is the distribution of old age pension benefits to recipients that reside in the rural areas of South Africa. Of importance to this study are the factors that promote and impinge on the development, implementation and acceptance of these applications. A specific project, the Pension Biometric Project was implemented by the South African Post Office in line with the government's initiatives of improving service delivery, and in response to the encroaching digital economy. The research problem is to investigate the pensioners' perception and their experience of three areas of this project, its implementation, its acceptance and its uses and impact. The research was conducted in the constructivist paradigm, using the case study research method. Three data collection methods were used, i.e. a document study of SAPO project documentation, on-site observations and interviews with pensioners. It was found that despite problems in implementation, the pensioners were accepting of the new system, although they were ignorant of the functionalities of the smart card. Consequently, few pensioners were making use of the banking facilities of the card, or had changed their economic behaviour. The study has also found that two themes are overriding all findings of the study. These two themes are ignorance and dignity. Ignorance has had a causal effect on adoption of the smart cards and dignity has been found to be a result of the project. The overriding implication of this study is that pensioners' ignorance around issues of service delivery by government and its agencies needs to be eradicated, otherwise there is no reliable way of measuring efforts against actual delivery. Also, the fact that dignity has emerged as an overriding theme needs to be deliberately strengthened, and maybe even driven as a specified objective of the Pension Biometric Project. Recommendations in this regard are provided as well as ideas for further research.
- Full Text:
- Date Issued: 2004
- Authors: Nyoka, Zanele
- Date: 2004
- Subjects: Old age pensioners -- South Africa -- Management Smart cards South African Post Office
- Language: English
- Type: Thesis , Masters , MBA
- Identifier: vital:818 , http://hdl.handle.net/10962/d1008052
- Description: E-commerce technologies have many possible applications both in commercial and non-commercial operations. The development and implementation of these applications is on the increase especially by government and its agencies, for the delivery of services. Specific to this study is the distribution of old age pension benefits to recipients that reside in the rural areas of South Africa. Of importance to this study are the factors that promote and impinge on the development, implementation and acceptance of these applications. A specific project, the Pension Biometric Project was implemented by the South African Post Office in line with the government's initiatives of improving service delivery, and in response to the encroaching digital economy. The research problem is to investigate the pensioners' perception and their experience of three areas of this project, its implementation, its acceptance and its uses and impact. The research was conducted in the constructivist paradigm, using the case study research method. Three data collection methods were used, i.e. a document study of SAPO project documentation, on-site observations and interviews with pensioners. It was found that despite problems in implementation, the pensioners were accepting of the new system, although they were ignorant of the functionalities of the smart card. Consequently, few pensioners were making use of the banking facilities of the card, or had changed their economic behaviour. The study has also found that two themes are overriding all findings of the study. These two themes are ignorance and dignity. Ignorance has had a causal effect on adoption of the smart cards and dignity has been found to be a result of the project. The overriding implication of this study is that pensioners' ignorance around issues of service delivery by government and its agencies needs to be eradicated, otherwise there is no reliable way of measuring efforts against actual delivery. Also, the fact that dignity has emerged as an overriding theme needs to be deliberately strengthened, and maybe even driven as a specified objective of the Pension Biometric Project. Recommendations in this regard are provided as well as ideas for further research.
- Full Text:
- Date Issued: 2004
First H F Doppler soundings of the ionosphere at SANAE
- Authors: De Kock, Errol James
- Date: 1980
- Subjects: Ionosphere
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5500 , http://hdl.handle.net/10962/d1006869 , Ionosphere
- Full Text:
- Date Issued: 1980
- Authors: De Kock, Errol James
- Date: 1980
- Subjects: Ionosphere
- Language: English
- Type: Thesis , Masters , MSc
- Identifier: vital:5500 , http://hdl.handle.net/10962/d1006869 , Ionosphere
- Full Text:
- Date Issued: 1980
A study of some aspects of the poor white problem in South Africa
- Authors: Lewis, Robert Alexander
- Date: 1979
- Subjects: Poor white problem , Afrikaners -- Economic conditions , Poor -- South Africa , South Africa -- Economic conditions , South Africa -- Social conditions
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2524 , http://hdl.handle.net/10962/d1001853
- Description: The first instance of the poor white problem being dramatically brought to the attention of white South Africa was in 1893 when Rev. Andrew Murray issued an open letter on the subject which resulted in the convening of the first of many Dutch Reformed Church conferences on the problem (Introduction, p. 1).
- Full Text:
- Date Issued: 1979
- Authors: Lewis, Robert Alexander
- Date: 1979
- Subjects: Poor white problem , Afrikaners -- Economic conditions , Poor -- South Africa , South Africa -- Economic conditions , South Africa -- Social conditions
- Language: English
- Type: text , Thesis , Masters , MA
- Identifier: vital:2524 , http://hdl.handle.net/10962/d1001853
- Description: The first instance of the poor white problem being dramatically brought to the attention of white South Africa was in 1893 when Rev. Andrew Murray issued an open letter on the subject which resulted in the convening of the first of many Dutch Reformed Church conferences on the problem (Introduction, p. 1).
- Full Text:
- Date Issued: 1979
The phytogeography of Southern Mistbelt Forests of the Eastern Cape, South Africa
- Authors: Matiwane, Aviwe
- Date: 2016
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/3224 , vital:20393
- Description: In the Eastern Cape, a moisture gradient (from west to east) exists along the Escarpment where patches of Southern Mistbelt Forests (SMF) occur. There is a notable profusion of plants in these forests, but the factors that drive plant species composition and abundance in these patches is poorly understood and such knowledge is critical if we are to address or mitigate the problems imposed by global change. Many of our ideas on plant community assembly are based on the premise that species differ in their environmental requirements for successful regeneration, especially when young. The aims of this study were to document the floristic diversity of poorly known patches of Southern Mistbelt Forests in the Eastern Cape and identify the environmental factors that influence plant community composition in these forest patches. Twenty six forest patches across the Eastern Cape were sampled. In each forest 400m2 circular plots were constructed. The diameter at breast height and stem counts for the tree species was taken and the % cover of the herbaceous species was recorded. General collections were also made to supplement the plot data in order to obtain a comprehensive flora for each forest patch. All sampling was done during the summer season of 2013 and 2014. Using plot data, Hierarchal Cluster Analysis and Multidimensional Scaling Analysis were done to compare similarities between patches. Plots from the same forest patch clustered which indicated that the species composition in each forest patch was unique. However, this pattern went down when only tree species were considered. Plant diversity also varied between patches; with those located in the east being generally more diverse than those in the west are. Clustering patterns in fragmented communities and differences in species diversity indicate evidence of species “nestedness”. Analysis of nestedness indicated that these forest patches were significantly nested. To identify which environmental variables might be correlated with both species diversity and nestedness, twelve environmental variables was selected for analysis using Canonical Correspondence Analysis and Principal Component Analysis. Results show that Mean Annual Precipitation, Mean Annual Potential Evapotranspiration, and percentage of Organic Matter of the soil were most strongly correlated with the patterns of diversity observed in these forest patches. Regression analysis indicated that Mean Annual Precipitation accounted for most of the variation in species diversity, especially for the herbaceous species. The herbaceous species thus show a greater sensitivity to “climate filtering” as a consequence of rainfall gradients. With the implementation of suitable monitoring programs, changes in abundance or even local extinction of these species can act as an early warning indicator of the possible long-term effects of climate change on forest communities.
- Full Text:
- Date Issued: 2016
- Authors: Matiwane, Aviwe
- Date: 2016
- Language: English
- Type: text , Thesis , Masters , MSc
- Identifier: http://hdl.handle.net/10962/3224 , vital:20393
- Description: In the Eastern Cape, a moisture gradient (from west to east) exists along the Escarpment where patches of Southern Mistbelt Forests (SMF) occur. There is a notable profusion of plants in these forests, but the factors that drive plant species composition and abundance in these patches is poorly understood and such knowledge is critical if we are to address or mitigate the problems imposed by global change. Many of our ideas on plant community assembly are based on the premise that species differ in their environmental requirements for successful regeneration, especially when young. The aims of this study were to document the floristic diversity of poorly known patches of Southern Mistbelt Forests in the Eastern Cape and identify the environmental factors that influence plant community composition in these forest patches. Twenty six forest patches across the Eastern Cape were sampled. In each forest 400m2 circular plots were constructed. The diameter at breast height and stem counts for the tree species was taken and the % cover of the herbaceous species was recorded. General collections were also made to supplement the plot data in order to obtain a comprehensive flora for each forest patch. All sampling was done during the summer season of 2013 and 2014. Using plot data, Hierarchal Cluster Analysis and Multidimensional Scaling Analysis were done to compare similarities between patches. Plots from the same forest patch clustered which indicated that the species composition in each forest patch was unique. However, this pattern went down when only tree species were considered. Plant diversity also varied between patches; with those located in the east being generally more diverse than those in the west are. Clustering patterns in fragmented communities and differences in species diversity indicate evidence of species “nestedness”. Analysis of nestedness indicated that these forest patches were significantly nested. To identify which environmental variables might be correlated with both species diversity and nestedness, twelve environmental variables was selected for analysis using Canonical Correspondence Analysis and Principal Component Analysis. Results show that Mean Annual Precipitation, Mean Annual Potential Evapotranspiration, and percentage of Organic Matter of the soil were most strongly correlated with the patterns of diversity observed in these forest patches. Regression analysis indicated that Mean Annual Precipitation accounted for most of the variation in species diversity, especially for the herbaceous species. The herbaceous species thus show a greater sensitivity to “climate filtering” as a consequence of rainfall gradients. With the implementation of suitable monitoring programs, changes in abundance or even local extinction of these species can act as an early warning indicator of the possible long-term effects of climate change on forest communities.
- Full Text:
- Date Issued: 2016
The design of a Memorial Park and a Promatorium complex in Humewood Extention, Port Elizabeth
- Authors: Cochrane, Camryn
- Date: 2018
- Subjects: Terrain vague -- South Africa -- Port Elizabeth
- Language: English
- Type: Thesis , Masters , MArch
- Identifier: http://hdl.handle.net/10948/23750 , vital:30616
- Description: This treatise is the result of an initial interest in the concept of ‘terrain vague’, the phenomenon of disconnected spaces that are internal to the city yet exist outside the effective and functioning networks of the urban system (Sola-Morales 1995, 120). The notion of terrain vague informs the theoretical preoccupation of this study and sets the basis on which the contextual and programmatic concerns are considered and explored. The harbour precinct of Port Elizabeth was selected as the focus area for the study, in which the characteristics of the terrain vague were uncovered through a series of maps, diagrams and photographs. The role of the cemetery as a type of terrain vague in the urban fabric is simultanelously investigated. The study refers to Richard Weller’s interpretation of the nature of the contemporary city and principles of landscape urbanism as a basis for developing ways of approaching the city and it’s spaces of terrain vague.Through this, the study is situated predominantly in the ecological discourse. The use of precedant studies as a means of exploring the application of the theoretical principles discussed in this study is key to providing the reader with a contextual understanding and clarity. The architectural intervention proposes a memorial park in the harbour precinct. This aims to generate a spatial awakening of the terrian vague. By reclaiming the denatured landscape (oil tank farm) and re-scripting it as a culturally significant area that is re-integrated into the public realm, the opportunity to rehabilitate the ecological flows of the city is realised. The design of a promatorium complex within the proposed memorial Park aims to re-introduce the funerary landscape into the city and in doing so challenges the threat of cemetries remaining as spaces of terrain vague. The promatorium complex is seen as a facility that supports the functions of the memorial park as a commemorative landscape in the 21st century. In all this intervention aims to transform a disregarded wasteland into an operational landscape. The aim is to enhance the ecological systems of the city and by extension to reconcile the interface between man and nature.
- Full Text:
- Date Issued: 2018
- Authors: Cochrane, Camryn
- Date: 2018
- Subjects: Terrain vague -- South Africa -- Port Elizabeth
- Language: English
- Type: Thesis , Masters , MArch
- Identifier: http://hdl.handle.net/10948/23750 , vital:30616
- Description: This treatise is the result of an initial interest in the concept of ‘terrain vague’, the phenomenon of disconnected spaces that are internal to the city yet exist outside the effective and functioning networks of the urban system (Sola-Morales 1995, 120). The notion of terrain vague informs the theoretical preoccupation of this study and sets the basis on which the contextual and programmatic concerns are considered and explored. The harbour precinct of Port Elizabeth was selected as the focus area for the study, in which the characteristics of the terrain vague were uncovered through a series of maps, diagrams and photographs. The role of the cemetery as a type of terrain vague in the urban fabric is simultanelously investigated. The study refers to Richard Weller’s interpretation of the nature of the contemporary city and principles of landscape urbanism as a basis for developing ways of approaching the city and it’s spaces of terrain vague.Through this, the study is situated predominantly in the ecological discourse. The use of precedant studies as a means of exploring the application of the theoretical principles discussed in this study is key to providing the reader with a contextual understanding and clarity. The architectural intervention proposes a memorial park in the harbour precinct. This aims to generate a spatial awakening of the terrian vague. By reclaiming the denatured landscape (oil tank farm) and re-scripting it as a culturally significant area that is re-integrated into the public realm, the opportunity to rehabilitate the ecological flows of the city is realised. The design of a promatorium complex within the proposed memorial Park aims to re-introduce the funerary landscape into the city and in doing so challenges the threat of cemetries remaining as spaces of terrain vague. The promatorium complex is seen as a facility that supports the functions of the memorial park as a commemorative landscape in the 21st century. In all this intervention aims to transform a disregarded wasteland into an operational landscape. The aim is to enhance the ecological systems of the city and by extension to reconcile the interface between man and nature.
- Full Text:
- Date Issued: 2018
Cuba's revolutionist and anti-imperialist foreign policy in Southern Africa: the case of Angola and Namibia
- Authors: Othieno, Timothy
- Date: 2000
- Subjects: Cuba -- Foreign Relations -- Africa, Southern , Cuba -- Dependency on foreign countries -- History , Cuba -- Foreign relations -- Angola , Cuba -- Foreign relations -- Namibia , Cuba -- Politics and government
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2819 , http://hdl.handle.net/10962/d1003029 , Cuba -- Foreign Relations -- Africa, Southern , Cuba -- Dependency on foreign countries -- History , Cuba -- Foreign relations -- Angola , Cuba -- Foreign relations -- Namibia , Cuba -- Politics and government
- Description: This study examines Cuba’s role in the two southern African countries of Angola and Namibia during the Cold War period. It argues that Cuba’s ideological motivations have been embodied in the mutually reinforcing concepts of proletarian internationalism and anti-imperialism. These conceptual perspectives constitute some of the central variables that influence Cuba’s foreign policy behaviour in international relations. It is within this context that one can understand Cuba’s involvement in Southern Africa. This study also attempts to explain that Cuban foreign policy towards Africa was based on two complementary and contextual objectives namely, promoting nationalism at home and nurturing revolutionary Marxist-Leninist governments, as well as supporting anti-colonial and anti-imperialist movements abroad. For the purpose of achieving these foreign policy objectives, Cuba not only engaged in state-to-state relations with Angola and Namibia; but had cordial relations with the rest of the continent and in particular Southern Africa, which also became a direct military testing ground for Cuba’s commitment to an anti-colonial and anti-imperialist revolutionary stance. Furthermore, the thesis shows that Cuba’s relentless hatred of imperialism is rooted in its historical relationship with the United States because from the turn of the century till 1958, the Americans interfered in Cuba’s internal affairs by supporting corrupt administrations and exploited the country. These practices by the United States laid the foundation for Cuba’s anti-colonialism and antiimperialism abroad. Ultimately, this thesis shows that Cuban involvement in Angola and Namibia can be conceptualised within these contexts (anti-imperialism, anti-colonialism, proletarian internationalism and revolutionary Marxism-Leninism). The role of Cuban nationalism in the realisation of these objectives and ideals, as well as its role in perpetuating and consolidating her foreign policy is assessed in this study. This nationalism and ideals of internationalism constitutes the central idea in the Cuban revolution. Finally, this thesis asserts that Cuban motives for getting involved in the politics of Southern Africa were not motivated by economic or imperialistic reasons. Rather, the historical similarity and colonial experiences between Africa and Cuba were some of the central causal factors.
- Full Text:
- Date Issued: 2000
- Authors: Othieno, Timothy
- Date: 2000
- Subjects: Cuba -- Foreign Relations -- Africa, Southern , Cuba -- Dependency on foreign countries -- History , Cuba -- Foreign relations -- Angola , Cuba -- Foreign relations -- Namibia , Cuba -- Politics and government
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:2819 , http://hdl.handle.net/10962/d1003029 , Cuba -- Foreign Relations -- Africa, Southern , Cuba -- Dependency on foreign countries -- History , Cuba -- Foreign relations -- Angola , Cuba -- Foreign relations -- Namibia , Cuba -- Politics and government
- Description: This study examines Cuba’s role in the two southern African countries of Angola and Namibia during the Cold War period. It argues that Cuba’s ideological motivations have been embodied in the mutually reinforcing concepts of proletarian internationalism and anti-imperialism. These conceptual perspectives constitute some of the central variables that influence Cuba’s foreign policy behaviour in international relations. It is within this context that one can understand Cuba’s involvement in Southern Africa. This study also attempts to explain that Cuban foreign policy towards Africa was based on two complementary and contextual objectives namely, promoting nationalism at home and nurturing revolutionary Marxist-Leninist governments, as well as supporting anti-colonial and anti-imperialist movements abroad. For the purpose of achieving these foreign policy objectives, Cuba not only engaged in state-to-state relations with Angola and Namibia; but had cordial relations with the rest of the continent and in particular Southern Africa, which also became a direct military testing ground for Cuba’s commitment to an anti-colonial and anti-imperialist revolutionary stance. Furthermore, the thesis shows that Cuba’s relentless hatred of imperialism is rooted in its historical relationship with the United States because from the turn of the century till 1958, the Americans interfered in Cuba’s internal affairs by supporting corrupt administrations and exploited the country. These practices by the United States laid the foundation for Cuba’s anti-colonialism and antiimperialism abroad. Ultimately, this thesis shows that Cuban involvement in Angola and Namibia can be conceptualised within these contexts (anti-imperialism, anti-colonialism, proletarian internationalism and revolutionary Marxism-Leninism). The role of Cuban nationalism in the realisation of these objectives and ideals, as well as its role in perpetuating and consolidating her foreign policy is assessed in this study. This nationalism and ideals of internationalism constitutes the central idea in the Cuban revolution. Finally, this thesis asserts that Cuban motives for getting involved in the politics of Southern Africa were not motivated by economic or imperialistic reasons. Rather, the historical similarity and colonial experiences between Africa and Cuba were some of the central causal factors.
- Full Text:
- Date Issued: 2000
Investigation of α-aryl substituted 3-indolylethanones as potential antiplasmodial agents
- Authors: Svogie, Archibald Lesley
- Date: 2016
- Language: English
- Type: text , Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10962/55487 , vital:26704
- Description: According to the World Health Organisation (WHO), deaths attributed to Plasmodium falciparum exceeded 584 000 in 2013, with 198 million new cases of malaria being reported. One contributing factor to these alarming figures is the emergence of drug resistance against available antimalarial agents. Therefore, there is a pressing need to develop new therapeutic antimalarial drugs with novel mechanisms of action in order to curb the increasing spread of malaria. The indole scaffold is often associated with biologically active compounds, recently exemplified by the antimalarial agent NITD609, which is currently in phase 1 clinical trials. Based on the biological evaluation of a small series of indolyl-3-amides and esters which showed moderate antimalarial activity, coupled to significant toxicity, we were prompted to investigate the synthesis of a series of indolyl-3-ethanone-α-amines (3.37 and 3.41), ethers (3.39 and 3.44) and thioethers (3.42, 3.43, 3.40, 3.45 – 3.73), where the carbonyl moiety and respective heteroatom were separated by a methine spacer. We further investigated these compounds for in vitro biological activity against P. falciparum and a human HeLa cell line. Our study explored the synthetic pathway of a three-step procedure toward our target compounds, with the initial Friedel-Crafts acetylation of indole, followed by α-bromination of the respective 3-acetylindoles. Finally, the halogen of the α-bromo ketone was substituted with an appropriate nucleophile, to yield our desired compounds. Various reagents were explored to optimise the nucleophilic displacement step, including potassium carbonate and various silver containing compounds. While many of the silver salts were found to assist in nucleophilic substitution, none were superior to the addition of potassium carbonate. The majority of compounds, chiefly the thioethers, displayed promising antimalarial activity, against the chloroquine sensitive 3D7 P. falciparum strain, with two thioethers in particular (3.54 and 3.65) inhibiting P. falciparum in the low nanomolar range. Additionally, active compounds were generally found to be non-toxic against HeLa cells, indicating that indolyl-3-thioethers are selective for the malaria parasite. These findings allowed us to begin hypothesising a structure activity relationship of this class, as well as elucidating the possible pharmacophore. In a speculative attempt to uncover the possible mechanism of action of these active compounds, in silico docking studies were conducted against Staphylococcus aureus HPPK (PDB ID: 4CRJ), which is an enzyme that immediately precedes DHPS in the microbial folate biosynthesis. Inhibition of folate biosynthesis is a validated selective antimalarial pathway and HPPK also exists in P. falciparum. Results from these docking studies suggested that our inhibitors bound well in the HPPK ATP pocket and were supportive of our hypothesized structure activity relationship.
- Full Text:
- Date Issued: 2016
- Authors: Svogie, Archibald Lesley
- Date: 2016
- Language: English
- Type: text , Thesis , Masters , MPharm
- Identifier: http://hdl.handle.net/10962/55487 , vital:26704
- Description: According to the World Health Organisation (WHO), deaths attributed to Plasmodium falciparum exceeded 584 000 in 2013, with 198 million new cases of malaria being reported. One contributing factor to these alarming figures is the emergence of drug resistance against available antimalarial agents. Therefore, there is a pressing need to develop new therapeutic antimalarial drugs with novel mechanisms of action in order to curb the increasing spread of malaria. The indole scaffold is often associated with biologically active compounds, recently exemplified by the antimalarial agent NITD609, which is currently in phase 1 clinical trials. Based on the biological evaluation of a small series of indolyl-3-amides and esters which showed moderate antimalarial activity, coupled to significant toxicity, we were prompted to investigate the synthesis of a series of indolyl-3-ethanone-α-amines (3.37 and 3.41), ethers (3.39 and 3.44) and thioethers (3.42, 3.43, 3.40, 3.45 – 3.73), where the carbonyl moiety and respective heteroatom were separated by a methine spacer. We further investigated these compounds for in vitro biological activity against P. falciparum and a human HeLa cell line. Our study explored the synthetic pathway of a three-step procedure toward our target compounds, with the initial Friedel-Crafts acetylation of indole, followed by α-bromination of the respective 3-acetylindoles. Finally, the halogen of the α-bromo ketone was substituted with an appropriate nucleophile, to yield our desired compounds. Various reagents were explored to optimise the nucleophilic displacement step, including potassium carbonate and various silver containing compounds. While many of the silver salts were found to assist in nucleophilic substitution, none were superior to the addition of potassium carbonate. The majority of compounds, chiefly the thioethers, displayed promising antimalarial activity, against the chloroquine sensitive 3D7 P. falciparum strain, with two thioethers in particular (3.54 and 3.65) inhibiting P. falciparum in the low nanomolar range. Additionally, active compounds were generally found to be non-toxic against HeLa cells, indicating that indolyl-3-thioethers are selective for the malaria parasite. These findings allowed us to begin hypothesising a structure activity relationship of this class, as well as elucidating the possible pharmacophore. In a speculative attempt to uncover the possible mechanism of action of these active compounds, in silico docking studies were conducted against Staphylococcus aureus HPPK (PDB ID: 4CRJ), which is an enzyme that immediately precedes DHPS in the microbial folate biosynthesis. Inhibition of folate biosynthesis is a validated selective antimalarial pathway and HPPK also exists in P. falciparum. Results from these docking studies suggested that our inhibitors bound well in the HPPK ATP pocket and were supportive of our hypothesized structure activity relationship.
- Full Text:
- Date Issued: 2016
The Impact of Automobile Trade on Economic Growth: A Comparative Study of South Africa and Brazil
- Bhasa, W
- Authors: Bhasa, W
- Date: 2018
- Subjects: Automobile industry and trade
- Language: English
- Type: Thesis , Masters , MCom (Economics)
- Identifier: http://hdl.handle.net/10353/13292 , vital:39631
- Description: Economic theory suggests that trade plays a critical role in the economic performance of a country. South Africa and Brazil’s automobile trade has been greatly influenced by government intervention through policy regimes with essentially similar objectives. Through the Automotive Production Development Programme in South Africa and the Plano Brasil Maior in Brazil, both countries have invested much effort in legislation, technology and capital to boost the automobile industry and overcome challenges of strengthening the automotive value chain, sustaining employment, raising productivity and increasing sales volumes both internally and on foreign markets. In light of such government interventions, this study investigates the contribution of the automobile trade on economic growth on South Africa and Brazil. The major concern is to determine whether the impact of the automobile trade is greater in South Africa and lesser in Brazil or vice-versa. This paper uses panel data analysis through the Least Squares Dummy Variable technique using quarterly data from 1995 to 2016. The regression results show that exports of automobiles, domestic investment in automobile trade, employment levels in the automobile industry together with the levels of general government expenditure positively affect GDP growth while imports of automobiles and inflation have a negative effect on general economic performance. Both countries should continue with automobile trade and governments should offer more production incentives and tax exemptions for component imports. Automobile industries are strategic industries which need government protection. Promotion of long-term partnerships and relationships within the automotive industry will play a critical role in boosting production with associated deepening of the components industry. The LSDV model results reveal that the individual country effects are statistically significant; this implies that the results for South Africa and Brazil differ. South Africa had a higher country coefficient which indicates that they benefitted more from the automobile trade than Braz
- Full Text:
- Date Issued: 2018
- Authors: Bhasa, W
- Date: 2018
- Subjects: Automobile industry and trade
- Language: English
- Type: Thesis , Masters , MCom (Economics)
- Identifier: http://hdl.handle.net/10353/13292 , vital:39631
- Description: Economic theory suggests that trade plays a critical role in the economic performance of a country. South Africa and Brazil’s automobile trade has been greatly influenced by government intervention through policy regimes with essentially similar objectives. Through the Automotive Production Development Programme in South Africa and the Plano Brasil Maior in Brazil, both countries have invested much effort in legislation, technology and capital to boost the automobile industry and overcome challenges of strengthening the automotive value chain, sustaining employment, raising productivity and increasing sales volumes both internally and on foreign markets. In light of such government interventions, this study investigates the contribution of the automobile trade on economic growth on South Africa and Brazil. The major concern is to determine whether the impact of the automobile trade is greater in South Africa and lesser in Brazil or vice-versa. This paper uses panel data analysis through the Least Squares Dummy Variable technique using quarterly data from 1995 to 2016. The regression results show that exports of automobiles, domestic investment in automobile trade, employment levels in the automobile industry together with the levels of general government expenditure positively affect GDP growth while imports of automobiles and inflation have a negative effect on general economic performance. Both countries should continue with automobile trade and governments should offer more production incentives and tax exemptions for component imports. Automobile industries are strategic industries which need government protection. Promotion of long-term partnerships and relationships within the automotive industry will play a critical role in boosting production with associated deepening of the components industry. The LSDV model results reveal that the individual country effects are statistically significant; this implies that the results for South Africa and Brazil differ. South Africa had a higher country coefficient which indicates that they benefitted more from the automobile trade than Braz
- Full Text:
- Date Issued: 2018
People-centred development in practice: the case of the Zikhova-Ngqinisa Sidibene Woodlot Trust Project
- Authors: Pona, Faith Zolisa
- Date: 2003
- Subjects: Zikhova-Ngqinisa Sidibene Woodlot Trust Project , Rural development -- South Africa -- Eastern Cape , Rural development projects -- South Africa -- Eastern Cape -- Citizen participation , Woodlots -- South Africa -- Eastern Cape , Economic development projects -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3356 , http://hdl.handle.net/10962/d1007610 , Zikhova-Ngqinisa Sidibene Woodlot Trust Project , Rural development -- South Africa -- Eastern Cape , Rural development projects -- South Africa -- Eastern Cape -- Citizen participation , Woodlots -- South Africa -- Eastern Cape , Economic development projects -- South Africa -- Eastern Cape
- Description: This study addresses the question of people-centred development as a transformative aspect of the new South African development arena. The concept is defined as the involvement and active participation of people in the decision-making, evaluation and implementation of the development processes, It is one of the forms of democratisation which involves the decentralisaton of authority to the lower tiers of government. This study provides an analysis of the efficacy, relevance, advantages and disadvantages of people-centred development in the South African context. The Zikhoya-Ngqinisa Woodlot Trust Project was chosen as a case study, The reason was that through the process of devolution of the Department of Forestry and Water Affairs (DWAF), which involved the handing over of the management and financial resources of the small woodlots to the communities for their own benefit, the two villages, Zikhova and Ngqinisa, were given the Zikhova woodlot. The devolution of DWAF is one of the various forms of decentralisation that has given more autonomy to the lower tiers of government in the sense that the communities now have to satisfy their own needs. The main focus of the study was to identify and analyse constraints on the implementation of people-centred development specific to the Zikhova-Ngqinisa Woodlot Trust Project. Other interrelated aspects of people-centred development such as sustainability, community involvement and benefits of the project were also investigated and analysed. , KMBT_363
- Full Text:
- Date Issued: 2003
- Authors: Pona, Faith Zolisa
- Date: 2003
- Subjects: Zikhova-Ngqinisa Sidibene Woodlot Trust Project , Rural development -- South Africa -- Eastern Cape , Rural development projects -- South Africa -- Eastern Cape -- Citizen participation , Woodlots -- South Africa -- Eastern Cape , Economic development projects -- South Africa -- Eastern Cape
- Language: English
- Type: Thesis , Masters , MA
- Identifier: vital:3356 , http://hdl.handle.net/10962/d1007610 , Zikhova-Ngqinisa Sidibene Woodlot Trust Project , Rural development -- South Africa -- Eastern Cape , Rural development projects -- South Africa -- Eastern Cape -- Citizen participation , Woodlots -- South Africa -- Eastern Cape , Economic development projects -- South Africa -- Eastern Cape
- Description: This study addresses the question of people-centred development as a transformative aspect of the new South African development arena. The concept is defined as the involvement and active participation of people in the decision-making, evaluation and implementation of the development processes, It is one of the forms of democratisation which involves the decentralisaton of authority to the lower tiers of government. This study provides an analysis of the efficacy, relevance, advantages and disadvantages of people-centred development in the South African context. The Zikhoya-Ngqinisa Woodlot Trust Project was chosen as a case study, The reason was that through the process of devolution of the Department of Forestry and Water Affairs (DWAF), which involved the handing over of the management and financial resources of the small woodlots to the communities for their own benefit, the two villages, Zikhova and Ngqinisa, were given the Zikhova woodlot. The devolution of DWAF is one of the various forms of decentralisation that has given more autonomy to the lower tiers of government in the sense that the communities now have to satisfy their own needs. The main focus of the study was to identify and analyse constraints on the implementation of people-centred development specific to the Zikhova-Ngqinisa Woodlot Trust Project. Other interrelated aspects of people-centred development such as sustainability, community involvement and benefits of the project were also investigated and analysed. , KMBT_363
- Full Text:
- Date Issued: 2003
Ubuntu: linking indigenous values with efforts in building a reconciled South Africa: the case of NMMU
- Authors: Pezisa, Lindiswa
- Date: 2017
- Subjects: Postcolonialism -- South Africa , South Africa -- Historiography -- Social aspects , Reparations for historical injustices -- South Africa , Xhosa (African people) -- Social life and customs
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/14477 , vital:27657
- Description: This thesis investigates the role that African indigenous value systems, Ubuntu in particular, could play in building a reconciled South Africa. In doing so a discourse analysis on Ubuntu is conducted and its potential in facilitating social cohesion in the quest for nation building. Specific focus is drawn on higher education an important task if we are to consider the accusation that higher education like its society, is still undergoing transformation and is under pressure to provide quality education for all people whilst also considering the large numbers of cultures that exist. For much needs to be done in redressing the imbalances caused by the apartheid education system which was organized according to racial lines. In doing so, Nelson Mandela Metropolitan University is utilised as a case study with narrative presentations of how students perceive this traditional African value and its applicability to reconciliation in a post conflict society. For seemingly, there is something inherently important about this value in that it has been invoked and referred to in many important instances in South African history.
- Full Text:
- Date Issued: 2017
- Authors: Pezisa, Lindiswa
- Date: 2017
- Subjects: Postcolonialism -- South Africa , South Africa -- Historiography -- Social aspects , Reparations for historical injustices -- South Africa , Xhosa (African people) -- Social life and customs
- Language: English
- Type: Thesis , Masters , MA
- Identifier: http://hdl.handle.net/10948/14477 , vital:27657
- Description: This thesis investigates the role that African indigenous value systems, Ubuntu in particular, could play in building a reconciled South Africa. In doing so a discourse analysis on Ubuntu is conducted and its potential in facilitating social cohesion in the quest for nation building. Specific focus is drawn on higher education an important task if we are to consider the accusation that higher education like its society, is still undergoing transformation and is under pressure to provide quality education for all people whilst also considering the large numbers of cultures that exist. For much needs to be done in redressing the imbalances caused by the apartheid education system which was organized according to racial lines. In doing so, Nelson Mandela Metropolitan University is utilised as a case study with narrative presentations of how students perceive this traditional African value and its applicability to reconciliation in a post conflict society. For seemingly, there is something inherently important about this value in that it has been invoked and referred to in many important instances in South African history.
- Full Text:
- Date Issued: 2017