Application of computer-aided drug design for identification of P. falciparum inhibitors
- Authors: Diallo, Bakary N’tji
- Date: 2021-10-29
- Subjects: Plasmodium falciparum , Malaria -- Chemotherapy , Molecular dynamics , Antimalarials , Cheminformatics , Drug development , Ligand binding (Biochemistry) , Plasmodium falciparum1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) , South African Natural Compounds Database
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/192798 , vital:45265 , 10.21504/10962/192798
- Description: Malaria is a millennia-old disease with the first recorded cases dating back to 2700 BC found in Chinese medical records, and later in other civilizations. It has claimed human lives to such an extent that there are a notable associated socio-economic consequences. Currently, according to the World Health Organization (WHO), Africa holds the highest disease burden with 94% of deaths and 82% of cases with P. falciparum having ~100% prevalence. Chemotherapy, such as artemisinin combination therapy, has been and continues to be the work horse in the fight against the disease, together with seasonal malaria chemoprevention and the use of insecticides. Natural products such as quinine and artemisinin are particularly important in terms of their antimalarial activity. The emphasis in current chemotherapy research is the need for time and cost-effective workflows focussed on new mechanisms of action (MoAs) covering the target candidate profiles (TCPs). Despite a decline in cases over the past decades with, countries increasingly becoming certified malaria free, a stalling trend has been observed in the past five years resulting in missing the 2020 Global Technical Strategy (GTS) milestones. With no effective vaccine, a reduction in funding, slower drug approval than resistance emergence from resistant and invasive vectors, and threats in diagnosis with the pfhrp2/3 gene deletion, malaria remains a major health concern. Motivated by these reasons, the primary aim of this work was a contribution to the antimalarial pipeline through in silico approaches focusing on P. falciparum. We first intended an exploration of malarial targets through a proteome scale screening on 36 targets using multiple metrics to account for the multi-objective nature of drug discovery. The continuous growth of structural data offers the ideal scenario for mining new MoAs covering antimalarials TCPs. This was combined with a repurposing strategy using a set of orally available FDA approved drugs. Further, use was made of time- and cost-effective strategies combining QVina-W efficiency metrics that integrate molecular properties, GRIM rescoring for molecular interactions and a hydrogen mass repartitioning (HMR) molecular dynamics (MD) scheme for accelerated development of antimalarials in the context of resistance. This pipeline further integrates a complex ranking for better drug-target selectivity, and normalization strategies to overcome docking scoring function bias. The different metrics, ranking, normalization strategies and their combinations were first assessed using their mean ranking error (MRE). A version combining all metrics was used to select 36 unique protein-ligand complexes, assessed in MD, with the final retention of 25. From the 16 in vitro tested hits of the 25, fingolimod, abiraterone, prazosin, and terazosin showed antiplasmodial activity with IC50 2.21, 3.37, 16.67 and 34.72 μM respectively and of these, only fingolimod was found to be not safe with respect to human cell viability. These compounds were predicted active on different molecular targets, abiraterone was predicted to interact with a putative liver-stage essential target, hence promising as a transmission-blocking agent. The pipeline had a promising 25% hit rate considering the proteome-scale and use of cost-effective approaches. Secondly, we focused on Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) using a more extensive screening pipeline to overcome some of the current in silico screening limitations. Starting from the ZINC lead-like library of ~3M, hierarchical ligand-based virtual screening (LBVS) and structure-based virtual screening (SBVS) approaches with molecular docking and re-scoring using eleven scoring functions (SFs) were used. Later ranking with an exponential consensus strategy was included. Selected hits were further assessed through Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA), advanced MD sampling in a ligand pulling simulations and (Weighted Histogram Analysis Method) WHAM analysis for umbrella sampling (US) to derive binding free energies. Four leads had better predicted affinities in US than LC5, a 280 nM potent PfDXR inhibitor with ZINC000050633276 showing a promising binding of -20.43 kcal/mol. As shown with fosmidomycin, DXR inhibition offers fast acting compounds fulfilling antimalarials TCP1. Yet, fosmidomycin has a high polarity causing its short half-life and hampering its clinical use. These leads scaffolds are different from fosmidomycin and hence may offer better pharmacokinetic and pharmacodynamic properties and may also be promising for lead optimization. A combined analysis of residues’ contributions to the free energy of binding in MM-PBSA and to steered molecular dynamics (SMD) Fmax indicated GLU233, CYS268, SER270, TRP296, and HIS341 as exploitable for compound optimization. Finally, we updated the SANCDB library with new NPs and their commercially available analogs as a solution to NP availability. The library is extended to 1005 compounds from its initial 600 compounds and the database is integrated to Mcule and Molport APIs for analogs automatic update. The new set may contribute to virtual screening and to antimalarials as the most effective ones have NP origin. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Diallo, Bakary N’tji
- Date: 2021-10-29
- Subjects: Plasmodium falciparum , Malaria -- Chemotherapy , Molecular dynamics , Antimalarials , Cheminformatics , Drug development , Ligand binding (Biochemistry) , Plasmodium falciparum1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) , South African Natural Compounds Database
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/192798 , vital:45265 , 10.21504/10962/192798
- Description: Malaria is a millennia-old disease with the first recorded cases dating back to 2700 BC found in Chinese medical records, and later in other civilizations. It has claimed human lives to such an extent that there are a notable associated socio-economic consequences. Currently, according to the World Health Organization (WHO), Africa holds the highest disease burden with 94% of deaths and 82% of cases with P. falciparum having ~100% prevalence. Chemotherapy, such as artemisinin combination therapy, has been and continues to be the work horse in the fight against the disease, together with seasonal malaria chemoprevention and the use of insecticides. Natural products such as quinine and artemisinin are particularly important in terms of their antimalarial activity. The emphasis in current chemotherapy research is the need for time and cost-effective workflows focussed on new mechanisms of action (MoAs) covering the target candidate profiles (TCPs). Despite a decline in cases over the past decades with, countries increasingly becoming certified malaria free, a stalling trend has been observed in the past five years resulting in missing the 2020 Global Technical Strategy (GTS) milestones. With no effective vaccine, a reduction in funding, slower drug approval than resistance emergence from resistant and invasive vectors, and threats in diagnosis with the pfhrp2/3 gene deletion, malaria remains a major health concern. Motivated by these reasons, the primary aim of this work was a contribution to the antimalarial pipeline through in silico approaches focusing on P. falciparum. We first intended an exploration of malarial targets through a proteome scale screening on 36 targets using multiple metrics to account for the multi-objective nature of drug discovery. The continuous growth of structural data offers the ideal scenario for mining new MoAs covering antimalarials TCPs. This was combined with a repurposing strategy using a set of orally available FDA approved drugs. Further, use was made of time- and cost-effective strategies combining QVina-W efficiency metrics that integrate molecular properties, GRIM rescoring for molecular interactions and a hydrogen mass repartitioning (HMR) molecular dynamics (MD) scheme for accelerated development of antimalarials in the context of resistance. This pipeline further integrates a complex ranking for better drug-target selectivity, and normalization strategies to overcome docking scoring function bias. The different metrics, ranking, normalization strategies and their combinations were first assessed using their mean ranking error (MRE). A version combining all metrics was used to select 36 unique protein-ligand complexes, assessed in MD, with the final retention of 25. From the 16 in vitro tested hits of the 25, fingolimod, abiraterone, prazosin, and terazosin showed antiplasmodial activity with IC50 2.21, 3.37, 16.67 and 34.72 μM respectively and of these, only fingolimod was found to be not safe with respect to human cell viability. These compounds were predicted active on different molecular targets, abiraterone was predicted to interact with a putative liver-stage essential target, hence promising as a transmission-blocking agent. The pipeline had a promising 25% hit rate considering the proteome-scale and use of cost-effective approaches. Secondly, we focused on Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) using a more extensive screening pipeline to overcome some of the current in silico screening limitations. Starting from the ZINC lead-like library of ~3M, hierarchical ligand-based virtual screening (LBVS) and structure-based virtual screening (SBVS) approaches with molecular docking and re-scoring using eleven scoring functions (SFs) were used. Later ranking with an exponential consensus strategy was included. Selected hits were further assessed through Molecular Mechanics Poisson-Boltzmann Surface Area (MM-PBSA), advanced MD sampling in a ligand pulling simulations and (Weighted Histogram Analysis Method) WHAM analysis for umbrella sampling (US) to derive binding free energies. Four leads had better predicted affinities in US than LC5, a 280 nM potent PfDXR inhibitor with ZINC000050633276 showing a promising binding of -20.43 kcal/mol. As shown with fosmidomycin, DXR inhibition offers fast acting compounds fulfilling antimalarials TCP1. Yet, fosmidomycin has a high polarity causing its short half-life and hampering its clinical use. These leads scaffolds are different from fosmidomycin and hence may offer better pharmacokinetic and pharmacodynamic properties and may also be promising for lead optimization. A combined analysis of residues’ contributions to the free energy of binding in MM-PBSA and to steered molecular dynamics (SMD) Fmax indicated GLU233, CYS268, SER270, TRP296, and HIS341 as exploitable for compound optimization. Finally, we updated the SANCDB library with new NPs and their commercially available analogs as a solution to NP availability. The library is extended to 1005 compounds from its initial 600 compounds and the database is integrated to Mcule and Molport APIs for analogs automatic update. The new set may contribute to virtual screening and to antimalarials as the most effective ones have NP origin. , Thesis (PhD) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
The construction of phthalocyanine- carbon nanoparticle conjugates for applications in photodynamic therapy and non-linear optics
- Matshitse, Refilwe Manyama Stephina
- Authors: Matshitse, Refilwe Manyama Stephina
- Date: 2021-10-29
- Subjects: Phthalocyanines , Nanodiamonds , Photochemotherapy , Nonlinear optics , Quantum dots
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/188397 , vital:44750 , 10.21504/10962/188397
- Description: The syntheses and characterization of symmetric and asymmetric Pcs functionalized at the peripheral position and sometimes positively charged are reported. The Pcs had either H2, zinc or silicon as central metals and have pyridyloxy, benzothiozole phenoxy, and respective cationic analogues as ring substituents. The Pcs were linked to carbon based nanoparticles such as graphene quantum dots, carbon dots, and detonation nanodiamonds (DNDs) via an ester, amide bond and/or π - π stacking. The physicochemical characteristics of the Pcs were assessed when alone and when in a conjugated system. Both symmetrically and asymmetrically substituted benzothiozole Pcs when quaternised displayed higher triplet and singlet oxygen quantum yields than their unquaternised counterparts. Linkage to carbon nanoparticles (especially to detonation nanodiamonds) had an increasing effect on triplet and singlet oxygen quantum yield. However, a general decrease in singlet oxygen quantum yield on linkage to doped detonation nanodiamonds was associated with the screening effect of DNDs. Heteroatom doped DNDs-Pc nanohybrids have less singlet oxygen than Pcs alone due to molecular structural stability associated with strain that is relatively reduced upon linking Pcs. The In vitro dark cytotoxicity and photodynamic therapy of selected Pc complexes and conjugates against MCF-7 cells was tested. All studied Pc complexes and conjugates showed minimum dark toxicity making them applicable for PDT. When Pc complexes are alone, there is less phototoxicity with >22% cell viability at concentrations ≤ 50 μg/mL relative to conjugates with <22% cell viability at concentrations ≤ 50 μg/mL. There was no direct relationship between PDT and singlet oxygen quantum yields. Nonlinear optical characteristics of complexes was improved upon conjugation of DNDs. Absorbance, input energy, percentage loading, central metal, substituent of Pc and nature of interaction (covalent, noncovalent) are amongst some of the factors that influence nonlinear absorption properties of materials used in this study. All materials followed reverse saturable absorption through two photon absorption mechanism at the excitation wavelength of 532 nm. Aggregates reduce excited state lifetime and Beff under high concentrations/absorbance. A direct relationship between absorbance and Beff of DNDs nanoconjugated systems at low concentrations result in increased optical limiting characteristics of materials. The findings from this work show the importance of linking (nonlinear optics and photodynamic therapy) and doping (photodynamic therapy) photosensitisers such as phthalocyanines and sometimes boron dipyrromethenes onto carbon based nanoparticles for the enhanced characteristics in variable applications. , Thesis (PhD) -- Faculty of Science, Chemistry, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Matshitse, Refilwe Manyama Stephina
- Date: 2021-10-29
- Subjects: Phthalocyanines , Nanodiamonds , Photochemotherapy , Nonlinear optics , Quantum dots
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/188397 , vital:44750 , 10.21504/10962/188397
- Description: The syntheses and characterization of symmetric and asymmetric Pcs functionalized at the peripheral position and sometimes positively charged are reported. The Pcs had either H2, zinc or silicon as central metals and have pyridyloxy, benzothiozole phenoxy, and respective cationic analogues as ring substituents. The Pcs were linked to carbon based nanoparticles such as graphene quantum dots, carbon dots, and detonation nanodiamonds (DNDs) via an ester, amide bond and/or π - π stacking. The physicochemical characteristics of the Pcs were assessed when alone and when in a conjugated system. Both symmetrically and asymmetrically substituted benzothiozole Pcs when quaternised displayed higher triplet and singlet oxygen quantum yields than their unquaternised counterparts. Linkage to carbon nanoparticles (especially to detonation nanodiamonds) had an increasing effect on triplet and singlet oxygen quantum yield. However, a general decrease in singlet oxygen quantum yield on linkage to doped detonation nanodiamonds was associated with the screening effect of DNDs. Heteroatom doped DNDs-Pc nanohybrids have less singlet oxygen than Pcs alone due to molecular structural stability associated with strain that is relatively reduced upon linking Pcs. The In vitro dark cytotoxicity and photodynamic therapy of selected Pc complexes and conjugates against MCF-7 cells was tested. All studied Pc complexes and conjugates showed minimum dark toxicity making them applicable for PDT. When Pc complexes are alone, there is less phototoxicity with >22% cell viability at concentrations ≤ 50 μg/mL relative to conjugates with <22% cell viability at concentrations ≤ 50 μg/mL. There was no direct relationship between PDT and singlet oxygen quantum yields. Nonlinear optical characteristics of complexes was improved upon conjugation of DNDs. Absorbance, input energy, percentage loading, central metal, substituent of Pc and nature of interaction (covalent, noncovalent) are amongst some of the factors that influence nonlinear absorption properties of materials used in this study. All materials followed reverse saturable absorption through two photon absorption mechanism at the excitation wavelength of 532 nm. Aggregates reduce excited state lifetime and Beff under high concentrations/absorbance. A direct relationship between absorbance and Beff of DNDs nanoconjugated systems at low concentrations result in increased optical limiting characteristics of materials. The findings from this work show the importance of linking (nonlinear optics and photodynamic therapy) and doping (photodynamic therapy) photosensitisers such as phthalocyanines and sometimes boron dipyrromethenes onto carbon based nanoparticles for the enhanced characteristics in variable applications. , Thesis (PhD) -- Faculty of Science, Chemistry, 2021
- Full Text:
- Date Issued: 2021-10-29
Performing Emil Hartmann – The Importance of Musical Contextualisation: A practice-based research project
- Authors: Robertson, Garreth Damon
- Date: 2021-10-29
- Subjects: Hartmann, Emil, 1836-1898 , Hartmann, Emil, 1836-1898 Criticism and interpretation History 19th century , Practice (Philosophy) , Research Methodology , Contextualism (Philosophy) , Music Denmark History and criticism , Music appreciation , Musical analysis
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190771 , vital:45026
- Description: When embarking on a journey of preparing a musical work for performance, a contextualisation process is undertaken which informs the performer/s of the factors which govern the parameters of the work. In this study, the author performed Emil Hartmann’s piano trio op. 10 as a part of an integrated master’s degree program. As the composer was not a part of mainland European musical society, information on his life and work was difficult to access, which presented the performer with a contextualisation problem. This study aimed to highlight the process of contextualisation, in the absence of sufficient literary material, through the lens of Emil Hartmann’s piano trio op. 10. The research used a three-pronged methodological approach in order to construct the narrative around Hartmann’s life and composition. Through a structured process of using practice-based research to analyse the creative process undertaken by the practitioners, alongside a micro-historical and analytical methodology, the study builds layers of understanding to inform Hartmann’s narrative, and thus provides interpretational insight into the execution of the work. The research finds that, although it is possible to interpret a musical work based on the musical score, there are layers of depth which cannot be accessed without a contextual understanding of the composer and the conditions in which the composition was written. Through forming the narrative on Emil Hartmann and his piano trio, the research uses the methodology to highlight a method which can be undertaken in the absence of contextual knowledge, and thus presents a contextual understanding of Emil Hartmann’s narrative. With the constructed knowledge, the author uses the findings based on the methodological approaches to weave a narrative around the life of Emil Hartmann. Applying the information discovered in the findings, interpretational approaches are discussed to inform future performances of the work. , Thesis (MMus) -- Faculty of Humanities, Music and Musicology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Robertson, Garreth Damon
- Date: 2021-10-29
- Subjects: Hartmann, Emil, 1836-1898 , Hartmann, Emil, 1836-1898 Criticism and interpretation History 19th century , Practice (Philosophy) , Research Methodology , Contextualism (Philosophy) , Music Denmark History and criticism , Music appreciation , Musical analysis
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190771 , vital:45026
- Description: When embarking on a journey of preparing a musical work for performance, a contextualisation process is undertaken which informs the performer/s of the factors which govern the parameters of the work. In this study, the author performed Emil Hartmann’s piano trio op. 10 as a part of an integrated master’s degree program. As the composer was not a part of mainland European musical society, information on his life and work was difficult to access, which presented the performer with a contextualisation problem. This study aimed to highlight the process of contextualisation, in the absence of sufficient literary material, through the lens of Emil Hartmann’s piano trio op. 10. The research used a three-pronged methodological approach in order to construct the narrative around Hartmann’s life and composition. Through a structured process of using practice-based research to analyse the creative process undertaken by the practitioners, alongside a micro-historical and analytical methodology, the study builds layers of understanding to inform Hartmann’s narrative, and thus provides interpretational insight into the execution of the work. The research finds that, although it is possible to interpret a musical work based on the musical score, there are layers of depth which cannot be accessed without a contextual understanding of the composer and the conditions in which the composition was written. Through forming the narrative on Emil Hartmann and his piano trio, the research uses the methodology to highlight a method which can be undertaken in the absence of contextual knowledge, and thus presents a contextual understanding of Emil Hartmann’s narrative. With the constructed knowledge, the author uses the findings based on the methodological approaches to weave a narrative around the life of Emil Hartmann. Applying the information discovered in the findings, interpretational approaches are discussed to inform future performances of the work. , Thesis (MMus) -- Faculty of Humanities, Music and Musicology, 2021
- Full Text:
- Date Issued: 2021-10-29
Peer-to-peer energy trading system using IoT and a low-computation blockchain network
- Authors: Ncube, Tyron
- Date: 2021-10-29
- Subjects: Blockchains (Databases) , Internet of things , Renewable energy sources , Smart power grids , Peer-to-peer architecture (Computer networks) , Energy trading system
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192119 , vital:45197
- Description: The use of renewable energy is increasing every year as it is seen as a viable and sustain- able long-term alternative to fossil-based sources of power. Emerging technologies are being merged with existing renewable energy systems to address some of the challenges associated with renewable energy, such as reliability and limited storage facilities for the generated energy. The Internet of Things (IoT) has made it possible for consumers to make money by selling off excess energy back to the utility company through smart grids that allow bi-directional communication between the consumer and the utility company. The major drawback of this is that the utility company still plays a central role in this setup as they are the only buyer of this excess energy generated from renewable energy sources. This research intends to use blockchain technology by leveraging its decentralized architecture to enable other individuals to be able to purchase this excess energy. Blockchain technology is first explained in detail, and its main features, such as consensus mechanisms, are examined. This evaluation of blockchain technology gives rise to some design questions that are taken into consideration to create a low-energy, low-computation Ethereum-based blockchain network that is the foundation for a peer-to-peer energy trading system. The peer-to-peer energy trading system makes use of smart meters to collect data about energy usage and gives users a web-based interface where they can transact with each other. A smart contract is also designed to facilitate payments for transactions. Lastly, the system is tested by carrying out transactions and transferring energy from one node in the system to another. , Thesis (MSc) -- Faculty of Science, Computer Science, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Ncube, Tyron
- Date: 2021-10-29
- Subjects: Blockchains (Databases) , Internet of things , Renewable energy sources , Smart power grids , Peer-to-peer architecture (Computer networks) , Energy trading system
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192119 , vital:45197
- Description: The use of renewable energy is increasing every year as it is seen as a viable and sustain- able long-term alternative to fossil-based sources of power. Emerging technologies are being merged with existing renewable energy systems to address some of the challenges associated with renewable energy, such as reliability and limited storage facilities for the generated energy. The Internet of Things (IoT) has made it possible for consumers to make money by selling off excess energy back to the utility company through smart grids that allow bi-directional communication between the consumer and the utility company. The major drawback of this is that the utility company still plays a central role in this setup as they are the only buyer of this excess energy generated from renewable energy sources. This research intends to use blockchain technology by leveraging its decentralized architecture to enable other individuals to be able to purchase this excess energy. Blockchain technology is first explained in detail, and its main features, such as consensus mechanisms, are examined. This evaluation of blockchain technology gives rise to some design questions that are taken into consideration to create a low-energy, low-computation Ethereum-based blockchain network that is the foundation for a peer-to-peer energy trading system. The peer-to-peer energy trading system makes use of smart meters to collect data about energy usage and gives users a web-based interface where they can transact with each other. A smart contract is also designed to facilitate payments for transactions. Lastly, the system is tested by carrying out transactions and transferring energy from one node in the system to another. , Thesis (MSc) -- Faculty of Science, Computer Science, 2021
- Full Text:
- Date Issued: 2021-10-29
Thrice-born Dionysos: an analysis of the birth narrative of Dionysos in Nonnos of Panopolis’ Dionysiaca
- Authors: Mackay, Danielle Louize
- Date: 2021-10-29
- Subjects: Dionysus (Greek deity) , Zeus (Greek deity) , Nonnus, of Panopolis , Mythology, Greek , Epic poetry , Birth (Philosophy) in literature , Late antiquity , Bacchus
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192235 , vital:45209
- Description: The following paper aims to analyse lines 660 – 774 of Euripides’ Bacchae paying close attention to the representation of the bacchants in the account given to Pentheus by the herdsman.1 Accompanying the translation is a brief commentary further elaborated and discussed in the paper below. The purpose of this paper is to investigate how the Theban women are portrayed in the hills outside of Thebes and the implications this might for the inherent conception of the supposed structure of the polis and the oikos. Dionysos’ arrival in Thebes hails a systematic disruption of the social order of the Theban polis. His presence causes an inverting of all that is familiar to the Thebans, the unknown becomes known and the known reveals itself as unknown. Euripides’ Bacchae was first performed at the City Dionysia in 405 BCE, in the year after the tragedian’s death. The play dramatises the arrival of the god Dionysos to Thebes to exact vengeance on those responsible for his mother’s death and to establish his mysteries there (line 24f & 47f). Before one can begin any analysis of the text, it is important to establish the context established by the play, as this context is important to a fuller understanding of the text. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Mackay, Danielle Louize
- Date: 2021-10-29
- Subjects: Dionysus (Greek deity) , Zeus (Greek deity) , Nonnus, of Panopolis , Mythology, Greek , Epic poetry , Birth (Philosophy) in literature , Late antiquity , Bacchus
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192235 , vital:45209
- Description: The following paper aims to analyse lines 660 – 774 of Euripides’ Bacchae paying close attention to the representation of the bacchants in the account given to Pentheus by the herdsman.1 Accompanying the translation is a brief commentary further elaborated and discussed in the paper below. The purpose of this paper is to investigate how the Theban women are portrayed in the hills outside of Thebes and the implications this might for the inherent conception of the supposed structure of the polis and the oikos. Dionysos’ arrival in Thebes hails a systematic disruption of the social order of the Theban polis. His presence causes an inverting of all that is familiar to the Thebans, the unknown becomes known and the known reveals itself as unknown. Euripides’ Bacchae was first performed at the City Dionysia in 405 BCE, in the year after the tragedian’s death. The play dramatises the arrival of the god Dionysos to Thebes to exact vengeance on those responsible for his mother’s death and to establish his mysteries there (line 24f & 47f). Before one can begin any analysis of the text, it is important to establish the context established by the play, as this context is important to a fuller understanding of the text. , Thesis (MA) -- Faculty of Humanities, School of Languages and Literatures, 2021
- Full Text:
- Date Issued: 2021-10-29
Embodied difference in manhood: A sociological analysis of the intersection of visible physical impairments and manhood among Xhosa men in the Eastern Cape
- Authors: Sipungu, Thoko Andy
- Date: 2021-10-29
- Subjects: Masculinity South Africa Eastern Cape , Sex role South Africa Eastern Cape , Sex role Psychological aspects , Men with disabilities South Africa Eastern Cape , People with disabilities Social conditions , Xhosa (African people) South Africa Eastern Cape Social life and customs , Male domination (Social structure) South Africa Eastern Cape , Circumcision Social aspects South Africa Eastern Cape
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/191658 , vital:45145 , 10.21504/10962/191658
- Description: In this thesis, I outline possible answers to the question of what it means to be a Xhosa man living with a visible physical impairment. Drawing on 17 one-on-one in-depth interviews and through an interpretive phenomenological thematic analysis, this thesis explores the intersection of physical disabilities and manhood masculinity in Xhosa men in selected rural areas in the Eastern Cape, South Africa. The intention for this study is to better our understanding concerning the creation, negotiation, maintenance, and recreation of manhood identities by traditionally circumcised Xhosa men in the Eastern Cape who by birth, accident, or illness find themselves at the intersections of masculinity and physical disability. Research notes that the bodies of men with disabilities serve as a continual reminder that they are at odds with the expectations of the dominant manhood cultures. The main argument from this area of research is that men with disabilities are outside the hegemony because they undermine the normative role and shape of the body in Western cultures. However, this line of argumentation stands in sharp contrast to arguments that the hegemony in Xhosa manhood masculinity is primarily and conclusively achieved by having a traditionally circumcised penis without any consideration of the full embodiments of men. Therefore, this study, in the first instance, seeks to bring embodiment into the analyses of manhood by focusing on physical disability amongst traditionally circumcised Xhosa men. Through an embodied theoretical approach to their disabilities that accounts for the corporeal experience of impairment, and theories of masculinity that centre the context, this thesis establishes, in the first instance, the significance of embodiment in doing Xhosa manhood. Concerning the research aims and objectives, this study sheds light on what it means to be a Xhosa man living with visible physical impairment. In this regard, the original findings are classified according to each research aims and objective, as outlined below. Concerning the first research aim, I found that the participants struggle to speak about their bodies outside of physical labour/work despite their impairments. I explain their inability to talk about their disabled bodies by looking at traditional Xhosa initiation as a grantor of equality and sameness. Secondly, I argue that there is a higher premium on social bodies rather than physical bodies in this context, thus their inability to speak about their conditions. Lastly, I make connections between the participants’ inabilities to talk about their bodies and the lasting impact of colonial and apartheid histories. Concerning the second research aim, I explore ways and strategies they employ to respond to and negotiate Xhosa manhood masculinity's dominant cultural demands. In this regard, I note that the participants who acquired their impairments after initiation consider their disability as a second initiation because they see it as having set them back to square one regarding their manhood responsibilities. In contrast, the participants who acquired their disabilities post-initiation saw initiation as a gateway to a more respectable personhood status. I also note that there is an emergence of alternative Xhosa manhood masculinities. Lastly, I also found that contrary to western scholarship on disability and manhood, the participants distinguish between threatened manhood identity versus threatened status as a man. I outline how they arrive at this distinction. In terms of researching the last research aim, this thesis explores how the participants negotiate their ‘embodied difference’ in mundane everyday living. I explore their taken-for-granted routines in doing and being disabled Xhosa men every day. In this regard, this study presents original and interesting findings regarding sex and intimacy, social interactions and sociability, and everyday home living. , Thesis (PhD) -- Faculty of Humanities, Sociology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Sipungu, Thoko Andy
- Date: 2021-10-29
- Subjects: Masculinity South Africa Eastern Cape , Sex role South Africa Eastern Cape , Sex role Psychological aspects , Men with disabilities South Africa Eastern Cape , People with disabilities Social conditions , Xhosa (African people) South Africa Eastern Cape Social life and customs , Male domination (Social structure) South Africa Eastern Cape , Circumcision Social aspects South Africa Eastern Cape
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/191658 , vital:45145 , 10.21504/10962/191658
- Description: In this thesis, I outline possible answers to the question of what it means to be a Xhosa man living with a visible physical impairment. Drawing on 17 one-on-one in-depth interviews and through an interpretive phenomenological thematic analysis, this thesis explores the intersection of physical disabilities and manhood masculinity in Xhosa men in selected rural areas in the Eastern Cape, South Africa. The intention for this study is to better our understanding concerning the creation, negotiation, maintenance, and recreation of manhood identities by traditionally circumcised Xhosa men in the Eastern Cape who by birth, accident, or illness find themselves at the intersections of masculinity and physical disability. Research notes that the bodies of men with disabilities serve as a continual reminder that they are at odds with the expectations of the dominant manhood cultures. The main argument from this area of research is that men with disabilities are outside the hegemony because they undermine the normative role and shape of the body in Western cultures. However, this line of argumentation stands in sharp contrast to arguments that the hegemony in Xhosa manhood masculinity is primarily and conclusively achieved by having a traditionally circumcised penis without any consideration of the full embodiments of men. Therefore, this study, in the first instance, seeks to bring embodiment into the analyses of manhood by focusing on physical disability amongst traditionally circumcised Xhosa men. Through an embodied theoretical approach to their disabilities that accounts for the corporeal experience of impairment, and theories of masculinity that centre the context, this thesis establishes, in the first instance, the significance of embodiment in doing Xhosa manhood. Concerning the research aims and objectives, this study sheds light on what it means to be a Xhosa man living with visible physical impairment. In this regard, the original findings are classified according to each research aims and objective, as outlined below. Concerning the first research aim, I found that the participants struggle to speak about their bodies outside of physical labour/work despite their impairments. I explain their inability to talk about their disabled bodies by looking at traditional Xhosa initiation as a grantor of equality and sameness. Secondly, I argue that there is a higher premium on social bodies rather than physical bodies in this context, thus their inability to speak about their conditions. Lastly, I make connections between the participants’ inabilities to talk about their bodies and the lasting impact of colonial and apartheid histories. Concerning the second research aim, I explore ways and strategies they employ to respond to and negotiate Xhosa manhood masculinity's dominant cultural demands. In this regard, I note that the participants who acquired their impairments after initiation consider their disability as a second initiation because they see it as having set them back to square one regarding their manhood responsibilities. In contrast, the participants who acquired their disabilities post-initiation saw initiation as a gateway to a more respectable personhood status. I also note that there is an emergence of alternative Xhosa manhood masculinities. Lastly, I also found that contrary to western scholarship on disability and manhood, the participants distinguish between threatened manhood identity versus threatened status as a man. I outline how they arrive at this distinction. In terms of researching the last research aim, this thesis explores how the participants negotiate their ‘embodied difference’ in mundane everyday living. I explore their taken-for-granted routines in doing and being disabled Xhosa men every day. In this regard, this study presents original and interesting findings regarding sex and intimacy, social interactions and sociability, and everyday home living. , Thesis (PhD) -- Faculty of Humanities, Sociology, 2021
- Full Text:
- Date Issued: 2021-10-29
Integrative systematic structuring of the widespread psammophiid snakes (Psammophiidae): a multi-evidence species delineation approach
- Authors: Keates, Chad
- Date: 2021-10-29
- Subjects: Psammophis South Africa , Herpetology , Herpetology Africa , Molecular biology , Psammophis Classification , Psammophis Genetics , Psammophis Morphology , Psammophis Phylogeny , Morphology Mathematics , Psammophylax
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/295077 , vital:57288 , DOI 10.21504/10962/295079
- Description: Species form the foundations upon which we build our understanding of the natural world. Although a focus of much scientific attention, our understanding of species is stunted by the intrinsic ‘fuzziness’ of boundaries within nature. Due to the complexity of the evolutionary process, coupled with an ever-changing abiotic landscape, species are hard to delineate, even at the best of times. Whilst various species concepts and sophisticated delimitation methods have helped scientists tease apart species, many species complexes persist. This is because taxonomy is a discrete ordering system imposed upon the continuous and intercalated structure of life. To improve our understanding of a wide-ranging family of snakes, I investigated the taxonomy and evolutionary structuring within Psammophiidae using both molecular and morphological approaches, employing phylogenetic, phylogeographic, and morphometric analyses on the group. The systematic complexity of the family (as evidenced by past research) coupled with the group’s widespread distribution and ecological importance, made the taxon an ideal candidate for a broad-sweeping multi-level systematic analysis using multiple species delimitation methods. Additionally, in this thesis I attempted to build on the ground-breaking work of Christopher Kelly by addressing several knowledge gaps identified within the family, and in so doing, produce the most thorough evolutionary and taxonomic study of Psammophiidae possible. Given the taxonomic uncertainty associated with the family, Chapter Two used a representative sampling from every available species (near complete taxon sampling approach) in the family. The chapter used both standard and time-calibrated phylogenetic modelling and distance/threshold-based species delimitation, to elucidate the finer-level structuring within the family. Geometric morphometrics was used to determine whether there were diagnosable differences in head structure between the different genera. The final phylogenetic tree incorporated 320 samples, representing the most comprehensive phylogenetic reconstruction of the family to date. By using a near-complete taxon sampling approach, I was able to resolve previously unsupported relationships within the family whilst also identifying several novel instances of an under- and over-appreciation of species diversity within the family. Geometric morphometrics also identified clear distinctions between genera based on head shape (head width and ‘beakedness’). This chapter showcased the importance of complete taxon sampling and robust methodology for species delimitation and the deleterious effect of species concepts when implemented in isolation. In Chapter Three, I narrowed the scope of the study to focus on the genus level. Psammophylax (Fitzinger 1843) is an abundant, yet poorly studied genus of grass snakes, endemic to Africa. The generalist nature of the genus and wide-spanning distributions of the constituent species has given rise to several subspecies and a poor understanding of the taxonomic structuring within the genus. The overlapping distributions (sympatry) of many of Psammophylax species, coupled with the potential for cryptic speciation via mechanisms such as convergent evolution, made the group the ideal candidate for a broad-sweeping systematic study (as evidenced in Chapter Two). By applying the suite of analyses used in Chapter Two to the generic level, we aimed to determine the effectiveness of a multi-evidence species delineation approach when tackling systematic problems at lower taxonomic levels. A genetic phylogeny of six of the seven species was estimated using multiple phylogenetic and distance/ threshold-based species delimitation methods. To support the molecular analyses, we conducted morphological analyses on the body (traditional morphology) and head (geometric morphometrics) separately. Phylogenetic analyses recovered a similar topology to past studies, but with better resolution and node support. I found substantial genetic structuring within the genus, supported by significantly different head shapes between Ps. a. acutus and other Psammophylax species. Psammophylax a. acutus was recovered as sister to its congeners, and sequence divergence values and morphometrics supported its recognition as a new genus. Increased sampling in East Africa (Tanzania, Kenya, and Ethiopia) revealed that Psammophylax multisquamis is polyphyletic, necessitating the description of a new, morphologically cryptic, species from northern Tanzania. The distribution of Ps. multisquamis sensu stricto is likely restricted to Kenya and Ethiopia. Within this chapter, taxon-specific phylogenetic analyses yielded stronger intrageneric support as compared to Chapter Two, allowing for more defensible conclusions about taxonomical amendments. Geometric morphometrics proved similarly useful (as compared to Chapter Two) in teasing apart genera within the family but lacked the robustness to delineate species within Psammophylax with confidence, highlighting the apparent convergence of form within the genus. In Chapter Four, I investigated the evolutionary structuring within the Southern African endemic Psammophylax rhombeatus. The structural and environmental heterogeneity within the region has given rise to many morphological forms distributed throughout the country, with previous studies neglecting the associated molecular significance of these forms. Irrespective of their small sample sizes, both Chapter Two and Three identified substantial phylogenetic structuring within the species, making Ps. rhombeatus the ideal candidate for a multi-faceted systematic review, using a combination of phylogenetics, geometric morphometrics and, for the first time in this species, phylogeographic analyses. By investigating a single species, in detail, I was able to assess the effectiveness of the methodologies implemented in previous chapters on systematic sorting using the multi-evidence species delineation approach. Phylogenetic and haplotype analysis retrieved four well-supported clades: southeast South Africa (SESA), southwest South Africa (SWSA), north-eastern South Africa (NESA) and western South Africa (WSA). Although not variable enough to warrant taxonomic re-evaluation, the clades represented important genetic hotspots, with relatively high intraspecific genetic divergence values separating them, irrespective of the small geographic distances separating populations. This is likely a product of the taxon’s habitat-generalist lifestyle, enabling them to bypass vicariant barriers that might otherwise cause speciation in less versatile species. The clades are also geographically distinct, with little overlap, indicating previous vicariance, a finding that is supported by the split of Ps. rhombeatus from Ps. ocellatus in the mid-Pliocene, followed by the diversification of Ps. rhombeatus into four clades throughout the Pleistocene. The genetic structuring observed in Ps. rhombeatus may be a product of population expansion following ancient refugial isolation (potentially Last Glacial Maximum [LGM]). The molecular distinctiveness of the clades was not replicated in the morphological component of this chapter, with neither dorsal nor lateral geometric morphometric analyses of head shape showing any discernible distinctiveness based on geography. Whilst head shape has not been shown to be an effective delineator of evolutionary units at the species level (within this taxon), body colour, scalation, and snout-vent length has been linked to morphotypes within the species based on the work of Broadley (1966). These morphological groupings are loosely attributable to the molecular clades identified in the phylogenetic analyses, highlighting the complex interplay of genetic and morphological characteristics in the process of speciation, and their representation in systematic accounts. This thesis represents the most thorough evolutionary and systematic study of the family currently possible. In addition to identifying and describing both a new genus and species, this thesis also highlighted several instances of an over- and under-appreciation of species diversity within Psammophiidae. By applying a multi-evidence species delineation approach to this thesis, I show the intricacy of the evolutionary process (at various taxonomic levels) and showcase the ease to which species boundaries can be confounded when species concepts are implemented in isolation. These findings also highlighted the importance of sample size, sample range, species delimitation method on the outcome of taxonomic analyses, and their interpretation. Lastly, this thesis addressed the knowledge gaps left by Christopher Kelly’s PhD work and investigated the findings of recent papers that attempted to do the same. Whilst this study answers the questions of old, the taxon-intensive focus revealed several new knowledge gaps within the family, highlighting how much we know about snake systematics, and furthermore, how much we still need to learn about evolutionary structuring. , Thesis (PhD) -- Faculty of Science, Environmental Science, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Keates, Chad
- Date: 2021-10-29
- Subjects: Psammophis South Africa , Herpetology , Herpetology Africa , Molecular biology , Psammophis Classification , Psammophis Genetics , Psammophis Morphology , Psammophis Phylogeny , Morphology Mathematics , Psammophylax
- Language: English
- Type: Academic theses , Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/295077 , vital:57288 , DOI 10.21504/10962/295079
- Description: Species form the foundations upon which we build our understanding of the natural world. Although a focus of much scientific attention, our understanding of species is stunted by the intrinsic ‘fuzziness’ of boundaries within nature. Due to the complexity of the evolutionary process, coupled with an ever-changing abiotic landscape, species are hard to delineate, even at the best of times. Whilst various species concepts and sophisticated delimitation methods have helped scientists tease apart species, many species complexes persist. This is because taxonomy is a discrete ordering system imposed upon the continuous and intercalated structure of life. To improve our understanding of a wide-ranging family of snakes, I investigated the taxonomy and evolutionary structuring within Psammophiidae using both molecular and morphological approaches, employing phylogenetic, phylogeographic, and morphometric analyses on the group. The systematic complexity of the family (as evidenced by past research) coupled with the group’s widespread distribution and ecological importance, made the taxon an ideal candidate for a broad-sweeping multi-level systematic analysis using multiple species delimitation methods. Additionally, in this thesis I attempted to build on the ground-breaking work of Christopher Kelly by addressing several knowledge gaps identified within the family, and in so doing, produce the most thorough evolutionary and taxonomic study of Psammophiidae possible. Given the taxonomic uncertainty associated with the family, Chapter Two used a representative sampling from every available species (near complete taxon sampling approach) in the family. The chapter used both standard and time-calibrated phylogenetic modelling and distance/threshold-based species delimitation, to elucidate the finer-level structuring within the family. Geometric morphometrics was used to determine whether there were diagnosable differences in head structure between the different genera. The final phylogenetic tree incorporated 320 samples, representing the most comprehensive phylogenetic reconstruction of the family to date. By using a near-complete taxon sampling approach, I was able to resolve previously unsupported relationships within the family whilst also identifying several novel instances of an under- and over-appreciation of species diversity within the family. Geometric morphometrics also identified clear distinctions between genera based on head shape (head width and ‘beakedness’). This chapter showcased the importance of complete taxon sampling and robust methodology for species delimitation and the deleterious effect of species concepts when implemented in isolation. In Chapter Three, I narrowed the scope of the study to focus on the genus level. Psammophylax (Fitzinger 1843) is an abundant, yet poorly studied genus of grass snakes, endemic to Africa. The generalist nature of the genus and wide-spanning distributions of the constituent species has given rise to several subspecies and a poor understanding of the taxonomic structuring within the genus. The overlapping distributions (sympatry) of many of Psammophylax species, coupled with the potential for cryptic speciation via mechanisms such as convergent evolution, made the group the ideal candidate for a broad-sweeping systematic study (as evidenced in Chapter Two). By applying the suite of analyses used in Chapter Two to the generic level, we aimed to determine the effectiveness of a multi-evidence species delineation approach when tackling systematic problems at lower taxonomic levels. A genetic phylogeny of six of the seven species was estimated using multiple phylogenetic and distance/ threshold-based species delimitation methods. To support the molecular analyses, we conducted morphological analyses on the body (traditional morphology) and head (geometric morphometrics) separately. Phylogenetic analyses recovered a similar topology to past studies, but with better resolution and node support. I found substantial genetic structuring within the genus, supported by significantly different head shapes between Ps. a. acutus and other Psammophylax species. Psammophylax a. acutus was recovered as sister to its congeners, and sequence divergence values and morphometrics supported its recognition as a new genus. Increased sampling in East Africa (Tanzania, Kenya, and Ethiopia) revealed that Psammophylax multisquamis is polyphyletic, necessitating the description of a new, morphologically cryptic, species from northern Tanzania. The distribution of Ps. multisquamis sensu stricto is likely restricted to Kenya and Ethiopia. Within this chapter, taxon-specific phylogenetic analyses yielded stronger intrageneric support as compared to Chapter Two, allowing for more defensible conclusions about taxonomical amendments. Geometric morphometrics proved similarly useful (as compared to Chapter Two) in teasing apart genera within the family but lacked the robustness to delineate species within Psammophylax with confidence, highlighting the apparent convergence of form within the genus. In Chapter Four, I investigated the evolutionary structuring within the Southern African endemic Psammophylax rhombeatus. The structural and environmental heterogeneity within the region has given rise to many morphological forms distributed throughout the country, with previous studies neglecting the associated molecular significance of these forms. Irrespective of their small sample sizes, both Chapter Two and Three identified substantial phylogenetic structuring within the species, making Ps. rhombeatus the ideal candidate for a multi-faceted systematic review, using a combination of phylogenetics, geometric morphometrics and, for the first time in this species, phylogeographic analyses. By investigating a single species, in detail, I was able to assess the effectiveness of the methodologies implemented in previous chapters on systematic sorting using the multi-evidence species delineation approach. Phylogenetic and haplotype analysis retrieved four well-supported clades: southeast South Africa (SESA), southwest South Africa (SWSA), north-eastern South Africa (NESA) and western South Africa (WSA). Although not variable enough to warrant taxonomic re-evaluation, the clades represented important genetic hotspots, with relatively high intraspecific genetic divergence values separating them, irrespective of the small geographic distances separating populations. This is likely a product of the taxon’s habitat-generalist lifestyle, enabling them to bypass vicariant barriers that might otherwise cause speciation in less versatile species. The clades are also geographically distinct, with little overlap, indicating previous vicariance, a finding that is supported by the split of Ps. rhombeatus from Ps. ocellatus in the mid-Pliocene, followed by the diversification of Ps. rhombeatus into four clades throughout the Pleistocene. The genetic structuring observed in Ps. rhombeatus may be a product of population expansion following ancient refugial isolation (potentially Last Glacial Maximum [LGM]). The molecular distinctiveness of the clades was not replicated in the morphological component of this chapter, with neither dorsal nor lateral geometric morphometric analyses of head shape showing any discernible distinctiveness based on geography. Whilst head shape has not been shown to be an effective delineator of evolutionary units at the species level (within this taxon), body colour, scalation, and snout-vent length has been linked to morphotypes within the species based on the work of Broadley (1966). These morphological groupings are loosely attributable to the molecular clades identified in the phylogenetic analyses, highlighting the complex interplay of genetic and morphological characteristics in the process of speciation, and their representation in systematic accounts. This thesis represents the most thorough evolutionary and systematic study of the family currently possible. In addition to identifying and describing both a new genus and species, this thesis also highlighted several instances of an over- and under-appreciation of species diversity within Psammophiidae. By applying a multi-evidence species delineation approach to this thesis, I show the intricacy of the evolutionary process (at various taxonomic levels) and showcase the ease to which species boundaries can be confounded when species concepts are implemented in isolation. These findings also highlighted the importance of sample size, sample range, species delimitation method on the outcome of taxonomic analyses, and their interpretation. Lastly, this thesis addressed the knowledge gaps left by Christopher Kelly’s PhD work and investigated the findings of recent papers that attempted to do the same. Whilst this study answers the questions of old, the taxon-intensive focus revealed several new knowledge gaps within the family, highlighting how much we know about snake systematics, and furthermore, how much we still need to learn about evolutionary structuring. , Thesis (PhD) -- Faculty of Science, Environmental Science, 2021
- Full Text:
- Date Issued: 2021-10-29
Competing policy imperatives in Post-Apartheid South Africa: An analysis of the effects and larger significance of ESKOM restructuring on the South African automotive industry, 2005-2014
- Authors: Sibuyi, Lucas Nkosana
- Date: 2021-10-29
- Subjects: Eskom (Firm) , South Africa Colonial influence , Electric power Conservation South Africa , Electric utilities Government ownership South Africa , Electric utilities Privatization South Africa , Import substitution South Africa , Government business enterprises South Africa
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/192911 , vital:45278 , 10.21504/10962/192911
- Description: The state has played an indispensable, major role in the industrialisation of South Africa, and its transformation from an economy of agriculture and mining to one based on manufacturing and services by the 1970s. Large state-owned corporations in communications and transportation, finance, industry and power have been key to this process, which also involved an extensive (and racist form of) import substitution industrialisation (ISI) from the 1920s. The 1970s saw a shift towards neoliberal policies, first under the National-Party-led apartheid government and then under the African-National-Congress-led democratic government formed in 1994. Since the 1980s, this restructuring has profoundly affected state-owned enterprises (SOEs), including the monopoly electricity utility ESKOM, and manufacturing industries, such as the automotive sector. This thesis examines the evolution of and interaction between different areas of neoliberal policy, and their evolution over time through a consideration of the relationship between the restructuring of SOEs and manufacturing, with a focus on ESKOM and autotomotives respectively. Relying on interviews with senior officials, policymakers, union leaders and industrialists, as well as primary documents, the study examines the responses of OEMs in South Africa (BMW, Ford, General Motors, Mercedes Benz/Daimler, Nissan, Toyota and Volkswagen) to ESKOM’s actions, and analyses the root of these actions. It argues that while restructuring has been framed by a common framework, policy development and implementation is not coordinated or cohesive. ESKOM, for example, gutted investment in electricity and maintenance generation capacity to become profitable and create space for Independent Power Providers (IPPs) – neoliberal measures for which it was rewarded and lauded. This took place at a time when national policy emphasised the need to grow manufacturing and attract direct investment by creating an investor-friendly climate resting on infrastructure. It also took place when the Department of Trade and Industry (DTI) rolled out highly successful plans – also praised and rewarded – to help adjust automotives to open markets; the sector grew much larger than under ISI, while other sectors like textiles collapsed. ESKOM’s measures, however, led to a rapid decline in the capacity and stability of the power system, and directly contradicted the drive to expand and globalise manufacturing, in which automotives was now the leading edge. Corruption in the utility worsened, much of it through subcontracting measures rooted in neoliberal reforms, but this did not cause the basic problems. It is argued that this situation of competing policy imperatives reflects deeper, long-term problems in the South African state, including contradictory policies, uneven capacity and a lack of coordination. For example, there was no coordination between the DTI and stakeholder departments that regulate ESKOM, being the shareholder ministry, the Department of Public Enterprises (DPE) and its policy ministry, and the Department of Mineral Resources and Energy (DMRE). These types of problems did not start postapartheid, and post-1994 reforms have not adequately addressed them. What exists is not a “developmental” state, as policymakers hope, but a fractured state of an intermediate type that combines “developmental” and “predatory” features in a oneparty dominant system in which lines between ruling party and state blur, and state resources are leveraged for elite class formation. Such was the case under apartheid skippered by the NP, with Afrikanerisation, and it continues today post-apartheid under the ANC with BEE. Major reforms are needed, but not just in SOE governance or budgets, as many have suggested. If we are to take the nation forward, the basic design of the state must be reformed. The state needs professionalised, coherent policy-making and implementation, proper coordination of state entities and hard decisions. It should manage high levels of public infrastructure, guarantee political stability and credit ratings, and provide policy certainty and predictability. Without big reforms it will remain a chronic underperformer. , Thesis (PhD) -- Faculty of Humanities, Sociology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Sibuyi, Lucas Nkosana
- Date: 2021-10-29
- Subjects: Eskom (Firm) , South Africa Colonial influence , Electric power Conservation South Africa , Electric utilities Government ownership South Africa , Electric utilities Privatization South Africa , Import substitution South Africa , Government business enterprises South Africa
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/192911 , vital:45278 , 10.21504/10962/192911
- Description: The state has played an indispensable, major role in the industrialisation of South Africa, and its transformation from an economy of agriculture and mining to one based on manufacturing and services by the 1970s. Large state-owned corporations in communications and transportation, finance, industry and power have been key to this process, which also involved an extensive (and racist form of) import substitution industrialisation (ISI) from the 1920s. The 1970s saw a shift towards neoliberal policies, first under the National-Party-led apartheid government and then under the African-National-Congress-led democratic government formed in 1994. Since the 1980s, this restructuring has profoundly affected state-owned enterprises (SOEs), including the monopoly electricity utility ESKOM, and manufacturing industries, such as the automotive sector. This thesis examines the evolution of and interaction between different areas of neoliberal policy, and their evolution over time through a consideration of the relationship between the restructuring of SOEs and manufacturing, with a focus on ESKOM and autotomotives respectively. Relying on interviews with senior officials, policymakers, union leaders and industrialists, as well as primary documents, the study examines the responses of OEMs in South Africa (BMW, Ford, General Motors, Mercedes Benz/Daimler, Nissan, Toyota and Volkswagen) to ESKOM’s actions, and analyses the root of these actions. It argues that while restructuring has been framed by a common framework, policy development and implementation is not coordinated or cohesive. ESKOM, for example, gutted investment in electricity and maintenance generation capacity to become profitable and create space for Independent Power Providers (IPPs) – neoliberal measures for which it was rewarded and lauded. This took place at a time when national policy emphasised the need to grow manufacturing and attract direct investment by creating an investor-friendly climate resting on infrastructure. It also took place when the Department of Trade and Industry (DTI) rolled out highly successful plans – also praised and rewarded – to help adjust automotives to open markets; the sector grew much larger than under ISI, while other sectors like textiles collapsed. ESKOM’s measures, however, led to a rapid decline in the capacity and stability of the power system, and directly contradicted the drive to expand and globalise manufacturing, in which automotives was now the leading edge. Corruption in the utility worsened, much of it through subcontracting measures rooted in neoliberal reforms, but this did not cause the basic problems. It is argued that this situation of competing policy imperatives reflects deeper, long-term problems in the South African state, including contradictory policies, uneven capacity and a lack of coordination. For example, there was no coordination between the DTI and stakeholder departments that regulate ESKOM, being the shareholder ministry, the Department of Public Enterprises (DPE) and its policy ministry, and the Department of Mineral Resources and Energy (DMRE). These types of problems did not start postapartheid, and post-1994 reforms have not adequately addressed them. What exists is not a “developmental” state, as policymakers hope, but a fractured state of an intermediate type that combines “developmental” and “predatory” features in a oneparty dominant system in which lines between ruling party and state blur, and state resources are leveraged for elite class formation. Such was the case under apartheid skippered by the NP, with Afrikanerisation, and it continues today post-apartheid under the ANC with BEE. Major reforms are needed, but not just in SOE governance or budgets, as many have suggested. If we are to take the nation forward, the basic design of the state must be reformed. The state needs professionalised, coherent policy-making and implementation, proper coordination of state entities and hard decisions. It should manage high levels of public infrastructure, guarantee political stability and credit ratings, and provide policy certainty and predictability. Without big reforms it will remain a chronic underperformer. , Thesis (PhD) -- Faculty of Humanities, Sociology, 2021
- Full Text:
- Date Issued: 2021-10-29
Understanding human‐wildlife conflict: a geographic study of the Pringle Bay chacma baboon troop
- Authors: Parsons, Wendy Jennifer
- Date: 2021-10-29
- Subjects: Chacma baboon South Africa Pringle Bay , Human-animal relationships South Africa Pringle Bay , Radio collars , Geographic information systems , Chacma baboon South Africa Pringle Bay Geographical distribution , Chacma baboon Behavior South Africa Pringle Bay , Chacma baboon Effect of human beings on South Africa Pringle Bay , Geospatial data , User-generated content
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294828 , vital:57259
- Description: A better appreciation of the physical geography and environmental factors that play a role in the movement of the Chacma baboon troop in and around Pringle Bay (Overberg Municipality) and part of the Kogelberg Biosphere could lead to a better understanding of their movement. In turn, this insight may contribute to reducing the human‐wildlife conflict that has arisen in the town. Humanwildlife conflict escalated after the rapid urban development that followed the introduction of electricity in 1993. The baboon‐human conflict in Pringle Bay is, in part, due to habitat loss caused by urban development and the easy availability of food in the urban area. The wild animal’s natural behaviour (seeking food and fresh water) and the human way of living (food and waste management) has led to baboon habituation and increased raiding in the village. The objective of this geographic study was to understand the baboon troops spatial and temporal movements. Two methods are being used to track the baboon troop. The first method entails collection of data from GPS tracking collars which record the location of the baboons at 30 minute intervals. This is considered a reliable, but invasive and expensive method where the alpha male and female baboon had to be captured and fitted with tracking collars. The second method entails using volunteered geographic data, in this case, information from a WhatsApp baboon alert group. While this provided data at no real cost, the mining of the information was challenging and building a geodatabase was time consuming. However, this citizen science approach added valuable data and was able to identify human‐wildlife conflict sites in the urban area. The baboon location data was mapped using GIS. Primary and secondary spatial data was sourced and added to the geodatabase created in ArcMap 10.7. Various ArcMap tools were used in analysing the environmental factors (climate, vegetation, water sources and topography) together with the location data. Analysis of this data allowed the range of the baboons to be mapped, showing the maximum extent of the territory the baboons move in. The was refined by mapping their home range (defined as the area in which they spend 95% of the time) and their core area (in which they spend 50% of the time). High activity areas ‐ or hotspots ‐ were identified, as were the baboon sleep sites. The data allowed for habitat use and seasonal patterns of movement to be explored. A key finding of the research was that the baboons were observed outside of the urban area for 82% of the time. The baboons spent the majority of their time in mountain fynbos vegetation. Hotspot areas showing significant baboon activity were identified within the town and close correlation with their sleep sites and wetland areas was evident. No definitive seasonal or weather patterns were found that influence the baboon distribution. Baboon management is complex and difficult. The sustainability of the baboon troop is important for the biodiversity of the Kogelberg Biosphere Reserve. While the baboons should not be encouraged to enter the urban area, the residents should play a role in reducing the availability of food and baboonproofing their properties. The Overstrand Municipality also needs to address waste management and waste collection in the town. Understanding the biogeography of the baboons and implementing the above‐mentioned mitigating management measures would encourage human‐wildlife coexistence and inform future baboon management plans. , Thesis (MSc) -- Faculty of Science, Geography, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Parsons, Wendy Jennifer
- Date: 2021-10-29
- Subjects: Chacma baboon South Africa Pringle Bay , Human-animal relationships South Africa Pringle Bay , Radio collars , Geographic information systems , Chacma baboon South Africa Pringle Bay Geographical distribution , Chacma baboon Behavior South Africa Pringle Bay , Chacma baboon Effect of human beings on South Africa Pringle Bay , Geospatial data , User-generated content
- Language: English
- Type: Academic theses , Master's theses , text
- Identifier: http://hdl.handle.net/10962/294828 , vital:57259
- Description: A better appreciation of the physical geography and environmental factors that play a role in the movement of the Chacma baboon troop in and around Pringle Bay (Overberg Municipality) and part of the Kogelberg Biosphere could lead to a better understanding of their movement. In turn, this insight may contribute to reducing the human‐wildlife conflict that has arisen in the town. Humanwildlife conflict escalated after the rapid urban development that followed the introduction of electricity in 1993. The baboon‐human conflict in Pringle Bay is, in part, due to habitat loss caused by urban development and the easy availability of food in the urban area. The wild animal’s natural behaviour (seeking food and fresh water) and the human way of living (food and waste management) has led to baboon habituation and increased raiding in the village. The objective of this geographic study was to understand the baboon troops spatial and temporal movements. Two methods are being used to track the baboon troop. The first method entails collection of data from GPS tracking collars which record the location of the baboons at 30 minute intervals. This is considered a reliable, but invasive and expensive method where the alpha male and female baboon had to be captured and fitted with tracking collars. The second method entails using volunteered geographic data, in this case, information from a WhatsApp baboon alert group. While this provided data at no real cost, the mining of the information was challenging and building a geodatabase was time consuming. However, this citizen science approach added valuable data and was able to identify human‐wildlife conflict sites in the urban area. The baboon location data was mapped using GIS. Primary and secondary spatial data was sourced and added to the geodatabase created in ArcMap 10.7. Various ArcMap tools were used in analysing the environmental factors (climate, vegetation, water sources and topography) together with the location data. Analysis of this data allowed the range of the baboons to be mapped, showing the maximum extent of the territory the baboons move in. The was refined by mapping their home range (defined as the area in which they spend 95% of the time) and their core area (in which they spend 50% of the time). High activity areas ‐ or hotspots ‐ were identified, as were the baboon sleep sites. The data allowed for habitat use and seasonal patterns of movement to be explored. A key finding of the research was that the baboons were observed outside of the urban area for 82% of the time. The baboons spent the majority of their time in mountain fynbos vegetation. Hotspot areas showing significant baboon activity were identified within the town and close correlation with their sleep sites and wetland areas was evident. No definitive seasonal or weather patterns were found that influence the baboon distribution. Baboon management is complex and difficult. The sustainability of the baboon troop is important for the biodiversity of the Kogelberg Biosphere Reserve. While the baboons should not be encouraged to enter the urban area, the residents should play a role in reducing the availability of food and baboonproofing their properties. The Overstrand Municipality also needs to address waste management and waste collection in the town. Understanding the biogeography of the baboons and implementing the above‐mentioned mitigating management measures would encourage human‐wildlife coexistence and inform future baboon management plans. , Thesis (MSc) -- Faculty of Science, Geography, 2021
- Full Text:
- Date Issued: 2021-10-29
Former farm workers of foreign descent in communal areas in post-fast track Zimbabwe : the case of Shamva District
- Authors: Chadambuka, Patience
- Date: 2021-10-29
- Subjects: Migrant agricultural laborers -- Zimbabwe -- Shamva District , Agricultural laborers, Foreign -- Zimbabwe -- Shamva District , Land reform -- Zimbabwe , Belonging (Social psychology) -- Zimbabwe -- Shamva District , Social integration-- Zimbabwe -- Shamva District , Fast Track Land Reform Programme (FTLRP)
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/178420 , vital:42938 , 10.21504/10962/178420
- Description: Land and ethnicity continue to condition contestations in relation to belonging amongst rural Zimbabweans. The colonial era defined Zimbabwe’s land politics in a highly racialised and ethnicised manner. Racially, the colonial era gave birth to white-owned fertile farm lands, while blacks (or Africans) were resettled in agriculturally-unproductive Reserves, later referred to as communal areas in the post-colonial era. Though they were initially created with a segregatory and oppressive intent bent on disenfranchising native Africans, the Reserves became a definitive landscape embedded in ethnic and ancestral belonging for the autochthonous Natives. The Reserves were created exclusively for autochthonous Africans, and the colonial administration ensured that foreign migrant Africans recruited mainly as covenanted labour from nearby colonies would not be accommodated and consequently belong in Reserves. Migrant Africans were instead domiciled in white commercial farms, mines and urban areas, and deprived of land rights accorded to the autochthones. In the case of white farms specifically, the labourers experienced a conditional belonging (to the farm). This overall exclusionary system was later inherited and maintained by the post-colonial Zimbabwean government, up until the year 2000. Zimbabwe’s highly documented Fast Track Land Reform Programme (FTLRP) from the year 2000 did away with the entrenched racial bifurcations of land, as white commercial farms became fast track farms. However, it did not undercut the existence of communal areas. The FTLRP had a profound effect on the lives of commercial farm workers, particularly those of foreign origin who had no other home or source of livelihood to fall back on after fast track displacements. Some though sought to move into communal areas, from which they had been excluded previously. Within this context, most scholarly studies of the post fast track period ignore the plight of former farm workers especially those that moved to, and into, communal areas. This ethnographic study, specifically of former farm workers of foreign origin in Shamva communal areas, therefore seeks to contribute to Zimbabwean studies in this regard. It documents and examines the perceptions, practices and lived experiences of former farm workers of foreign origin now residing in the Bushu communal areas of Shamva, and how they interface with Bushu autochthones in seeking to belong to Bushu. This is pursued by way of qualitative research methods (including lengthy stays in the study sites) as well as through the use of a theoretical framing focusing on lifeworlds, interfaces, belonging, othering and strangerhood. Key findings reveal that belonging by the former farm workers in Bushu entails a non-linear and convoluted process characterised by a series of contestations around for instance land shortages, limited livelihood strategies and cultural difference. This project of belonging does not entail assimilation on the part of the former farm workers, as they continue to uphold certain historical practices, leading to a form of co-existence between the autochthones and allochthones in Bushu. In this way, the former farm workers seem to develop a conditional belonging in (and to) Bushu, albeit different than the one experienced on white farms in the past. , Thesis (PhD) -- Faculty of Humanities, Sociology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Chadambuka, Patience
- Date: 2021-10-29
- Subjects: Migrant agricultural laborers -- Zimbabwe -- Shamva District , Agricultural laborers, Foreign -- Zimbabwe -- Shamva District , Land reform -- Zimbabwe , Belonging (Social psychology) -- Zimbabwe -- Shamva District , Social integration-- Zimbabwe -- Shamva District , Fast Track Land Reform Programme (FTLRP)
- Language: English
- Type: thesis , text , Doctoral , PhD
- Identifier: http://hdl.handle.net/10962/178420 , vital:42938 , 10.21504/10962/178420
- Description: Land and ethnicity continue to condition contestations in relation to belonging amongst rural Zimbabweans. The colonial era defined Zimbabwe’s land politics in a highly racialised and ethnicised manner. Racially, the colonial era gave birth to white-owned fertile farm lands, while blacks (or Africans) were resettled in agriculturally-unproductive Reserves, later referred to as communal areas in the post-colonial era. Though they were initially created with a segregatory and oppressive intent bent on disenfranchising native Africans, the Reserves became a definitive landscape embedded in ethnic and ancestral belonging for the autochthonous Natives. The Reserves were created exclusively for autochthonous Africans, and the colonial administration ensured that foreign migrant Africans recruited mainly as covenanted labour from nearby colonies would not be accommodated and consequently belong in Reserves. Migrant Africans were instead domiciled in white commercial farms, mines and urban areas, and deprived of land rights accorded to the autochthones. In the case of white farms specifically, the labourers experienced a conditional belonging (to the farm). This overall exclusionary system was later inherited and maintained by the post-colonial Zimbabwean government, up until the year 2000. Zimbabwe’s highly documented Fast Track Land Reform Programme (FTLRP) from the year 2000 did away with the entrenched racial bifurcations of land, as white commercial farms became fast track farms. However, it did not undercut the existence of communal areas. The FTLRP had a profound effect on the lives of commercial farm workers, particularly those of foreign origin who had no other home or source of livelihood to fall back on after fast track displacements. Some though sought to move into communal areas, from which they had been excluded previously. Within this context, most scholarly studies of the post fast track period ignore the plight of former farm workers especially those that moved to, and into, communal areas. This ethnographic study, specifically of former farm workers of foreign origin in Shamva communal areas, therefore seeks to contribute to Zimbabwean studies in this regard. It documents and examines the perceptions, practices and lived experiences of former farm workers of foreign origin now residing in the Bushu communal areas of Shamva, and how they interface with Bushu autochthones in seeking to belong to Bushu. This is pursued by way of qualitative research methods (including lengthy stays in the study sites) as well as through the use of a theoretical framing focusing on lifeworlds, interfaces, belonging, othering and strangerhood. Key findings reveal that belonging by the former farm workers in Bushu entails a non-linear and convoluted process characterised by a series of contestations around for instance land shortages, limited livelihood strategies and cultural difference. This project of belonging does not entail assimilation on the part of the former farm workers, as they continue to uphold certain historical practices, leading to a form of co-existence between the autochthones and allochthones in Bushu. In this way, the former farm workers seem to develop a conditional belonging in (and to) Bushu, albeit different than the one experienced on white farms in the past. , Thesis (PhD) -- Faculty of Humanities, Sociology, 2021
- Full Text:
- Date Issued: 2021-10-29
An interpretative phenomenological analysis of mothers’ experiences raising an autistic child
- Authors: Hewson, Aimee Jessica
- Date: 2021-10-29
- Subjects: Autism spectrum disorders South Africa , Autism spectrum disorders in children South Africa , Mothers of children with disabilities South Africa , Phenomenological psychology , Qualitative research , Interpretative phenomenological analysis
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190725 , vital:45022
- Description: There has been an increasing research focus on Autism Spectrum Disorder (ASD) and the experiences of those affected by autism. Previous research has demonstrated that mothers experience difficulties in all spheres related to their autistic child. Mothers were focused on exclusively in this study as previous research found that it is mostly mothers who take on the primary caring role for their children. As a result, this research aimed to explore the perceptions and experience of six South African mothers raising their ASD child. This research used a qualitative research approach and an interpretative phenomenological analysis methodology. Two semi-structured interviews were held with each participant, with interviews being audio recorded. After analysis, five themes were found, namely: (1) learning their child has a condition or diagnosis, (2) learning and sharing about ASD, (3) the mothering experience, (4) interventions and cost and (5) supportive resources. Careful anonymisation choices were made in this research to ensure the anonymity of participants as best as possible, due to the recruitment through a gatekeeper organisation and snowball sampling. The main findings of this study were that mothers experienced difficulties and challenges as they navigated the medical world in search of a diagnosis for their child. Mothers also reported following their intuition when it came to their children’s care, interventions, and schooling. The passage of time was a significant issue to mothers, as they described several delays and waiting periods. Mothers also described their concerns regarding their children’s future and the fact that their child would be dependent on them and would not be able to form autonomous mature relationships with others. They also reported various thoughts on disclosing their child’s diagnosis to their children. This research, therefore, added to and expanded upon South African literature on the experiences of mothers raising their ASD child. Concurring with previous research, this project found that mothers experience many challenges in the raising of their ASD child. , Thesis (MSocSci) -- Faculty of Humanities, Psychology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Hewson, Aimee Jessica
- Date: 2021-10-29
- Subjects: Autism spectrum disorders South Africa , Autism spectrum disorders in children South Africa , Mothers of children with disabilities South Africa , Phenomenological psychology , Qualitative research , Interpretative phenomenological analysis
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190725 , vital:45022
- Description: There has been an increasing research focus on Autism Spectrum Disorder (ASD) and the experiences of those affected by autism. Previous research has demonstrated that mothers experience difficulties in all spheres related to their autistic child. Mothers were focused on exclusively in this study as previous research found that it is mostly mothers who take on the primary caring role for their children. As a result, this research aimed to explore the perceptions and experience of six South African mothers raising their ASD child. This research used a qualitative research approach and an interpretative phenomenological analysis methodology. Two semi-structured interviews were held with each participant, with interviews being audio recorded. After analysis, five themes were found, namely: (1) learning their child has a condition or diagnosis, (2) learning and sharing about ASD, (3) the mothering experience, (4) interventions and cost and (5) supportive resources. Careful anonymisation choices were made in this research to ensure the anonymity of participants as best as possible, due to the recruitment through a gatekeeper organisation and snowball sampling. The main findings of this study were that mothers experienced difficulties and challenges as they navigated the medical world in search of a diagnosis for their child. Mothers also reported following their intuition when it came to their children’s care, interventions, and schooling. The passage of time was a significant issue to mothers, as they described several delays and waiting periods. Mothers also described their concerns regarding their children’s future and the fact that their child would be dependent on them and would not be able to form autonomous mature relationships with others. They also reported various thoughts on disclosing their child’s diagnosis to their children. This research, therefore, added to and expanded upon South African literature on the experiences of mothers raising their ASD child. Concurring with previous research, this project found that mothers experience many challenges in the raising of their ASD child. , Thesis (MSocSci) -- Faculty of Humanities, Psychology, 2021
- Full Text:
- Date Issued: 2021-10-29
Exploring the use of in vitro colorimetric and bioluminescence assays to distinguish between Arf GTPase isoforms and detect Arf GTPase activity
- Authors: Woolf, Alexander Robert
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192582 , vital:45240
- Description: Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Woolf, Alexander Robert
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192582 , vital:45240
- Description: Thesis (MSc) -- Faculty of Science, Biochemistry and Microbiology, 2021
- Full Text:
- Date Issued: 2021-10-29
Ethics matter: A critical realist account of research ethics for social science and humanities researchers
- Authors: Dlova, Lisolethu
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192440 , vital:45226
- Description: Thesis (MEd) -- Faculty of Education, Centre for Higher Education Research, Teaching and Learning, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Dlova, Lisolethu
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192440 , vital:45226
- Description: Thesis (MEd) -- Faculty of Education, Centre for Higher Education Research, Teaching and Learning, 2021
- Full Text:
- Date Issued: 2021-10-29
The influence of selected classes of surfactants on microbial fuel cell performance: extensive analysis of microbial activity, bioremediation and power generation for wastewater treatment
- Authors: Lipali, Molopo Johannes
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192493 , vital:45231
- Description: Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Lipali, Molopo Johannes
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192493 , vital:45231
- Description: Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2021
- Full Text:
- Date Issued: 2021-10-29
Genetic relationships between migmatites and the Swartoup Pluton in the Swartoup Hills (central Namaqua Belt)
- Authors: Schmeldt, Graeme Alvin
- Date: 2021-10-29
- Subjects: Migmatite South Africa Northern Cape , Intrusions (Geology) South Africa , Metamorphic rocks South Africa Northern Cape , Metamorphism (Geology) South Africa Northern Cape , Onseepkans (South Africa) , Namaqualand (South Africa) , Anatexis , Swartoup , Koenap
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192162 , vital:45201
- Description: The central Namaqua Metamorphic Complex can be characterised by long-standing high-temperature (up to granulite/amphibolite facies) conditions between _ 1300 and 1100Ma, inevitably resulting in widespread metamorphism and plutonism. Hosted within a NW–SE striking antiformal structure about 40 km east of Onseepkans, Northen Cape, South Africa, in the Swartoup Hills, lies the Swartoup Pluton. The Swartoup Pluton was sampled and described in hand specimen and thin section. The study area was photographed, with all data presented in this study. The various rock types are readily discerned in the field due to their characteristic weathering colours and overall fabrics. The Swartoup granodioritic body is hosted within metasediments of the Bysteek and Koenap Formations, of the Arribees Group. The package was later intruded by another later granitoid, the Polisiehoek Granite-gneiss. The Bysteek Formation, a wall rock to the S-type Swartoup Pluton, reacted at the contact with the igneous body resulting in localised feldspathic granites and granodiorites with prominent, often euhedral, garnet, pryoxene and titanite. The Swartoup Pluton is divided into two subgroups. The first is characterised by higher P2O5 contents, _ 0.3 – 0.4 wt.%, shown with a narrower constraint on its Rb contents, _ 80 – 160 ppm, than the second, with _ 0.14 – 0.4 wt.% P2O5 and 20 – 310 ppm Rb. Meanwhile the Polisiehoek Granite-gneiss shows _ 50 – 420 ppm Rb and _ 0.04 – 0:1 wt% P2O5. As a whole, the Swartoup Pluton is characterised by somewhat elevated CaO concentrations (_ 1.5 – 6.0 wt.%), relative to calculated averages of granites (1.8 wt.% CaO, Le Maitre, 1976) and granodiorites (3.9 wt.% CaO, Le Maitre, 1976). Whilst most of the Swartoup specimens were classified as granodiorites, some orthopyroxene-bearing monzodiorite and orthopyroxenebearing monzonite were locally found and sampled. However, much of the body appears to be granodioritic to granitic in composition. The Polisiehoek Granite-gneiss is characterised by its orange-brown weathering colour in the field, sheared texture, lower P2O5 and higher total alkali content than the Swartoup Pluton. The Polisiehoek Granite-gneiss is a highly fractionated S-type granite, as shown by plots of (a) (Na2O + K2O)/CaO and (b) FeOT/MgO versus Zr + Nb + Ce + Y (Whalen et al., 1987; Zhang et al., 2019) and also of (c) (Al2O3 + CaO)/(FeOT + Na2O + K2O) versus 100 × (MgO + FeOT + TiO2)/SiO2 (after Sylvester, 1989). Classification schemes identify the Polisiehoek Granite-gneiss as either a granite (TAS diagram, after Middlemost, 1994) or alkali granite (R1R2 diagram, after De la Roche et al., 1980). , Thesis (MSc) -- Faculty of Science, Geology, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Schmeldt, Graeme Alvin
- Date: 2021-10-29
- Subjects: Migmatite South Africa Northern Cape , Intrusions (Geology) South Africa , Metamorphic rocks South Africa Northern Cape , Metamorphism (Geology) South Africa Northern Cape , Onseepkans (South Africa) , Namaqualand (South Africa) , Anatexis , Swartoup , Koenap
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192162 , vital:45201
- Description: The central Namaqua Metamorphic Complex can be characterised by long-standing high-temperature (up to granulite/amphibolite facies) conditions between _ 1300 and 1100Ma, inevitably resulting in widespread metamorphism and plutonism. Hosted within a NW–SE striking antiformal structure about 40 km east of Onseepkans, Northen Cape, South Africa, in the Swartoup Hills, lies the Swartoup Pluton. The Swartoup Pluton was sampled and described in hand specimen and thin section. The study area was photographed, with all data presented in this study. The various rock types are readily discerned in the field due to their characteristic weathering colours and overall fabrics. The Swartoup granodioritic body is hosted within metasediments of the Bysteek and Koenap Formations, of the Arribees Group. The package was later intruded by another later granitoid, the Polisiehoek Granite-gneiss. The Bysteek Formation, a wall rock to the S-type Swartoup Pluton, reacted at the contact with the igneous body resulting in localised feldspathic granites and granodiorites with prominent, often euhedral, garnet, pryoxene and titanite. The Swartoup Pluton is divided into two subgroups. The first is characterised by higher P2O5 contents, _ 0.3 – 0.4 wt.%, shown with a narrower constraint on its Rb contents, _ 80 – 160 ppm, than the second, with _ 0.14 – 0.4 wt.% P2O5 and 20 – 310 ppm Rb. Meanwhile the Polisiehoek Granite-gneiss shows _ 50 – 420 ppm Rb and _ 0.04 – 0:1 wt% P2O5. As a whole, the Swartoup Pluton is characterised by somewhat elevated CaO concentrations (_ 1.5 – 6.0 wt.%), relative to calculated averages of granites (1.8 wt.% CaO, Le Maitre, 1976) and granodiorites (3.9 wt.% CaO, Le Maitre, 1976). Whilst most of the Swartoup specimens were classified as granodiorites, some orthopyroxene-bearing monzodiorite and orthopyroxenebearing monzonite were locally found and sampled. However, much of the body appears to be granodioritic to granitic in composition. The Polisiehoek Granite-gneiss is characterised by its orange-brown weathering colour in the field, sheared texture, lower P2O5 and higher total alkali content than the Swartoup Pluton. The Polisiehoek Granite-gneiss is a highly fractionated S-type granite, as shown by plots of (a) (Na2O + K2O)/CaO and (b) FeOT/MgO versus Zr + Nb + Ce + Y (Whalen et al., 1987; Zhang et al., 2019) and also of (c) (Al2O3 + CaO)/(FeOT + Na2O + K2O) versus 100 × (MgO + FeOT + TiO2)/SiO2 (after Sylvester, 1989). Classification schemes identify the Polisiehoek Granite-gneiss as either a granite (TAS diagram, after Middlemost, 1994) or alkali granite (R1R2 diagram, after De la Roche et al., 1980). , Thesis (MSc) -- Faculty of Science, Geology, 2021
- Full Text:
- Date Issued: 2021-10-29
Towards effective monitoring, control and surveillance policy and implementation in South Africa and its relevance to other Southern African States
- Authors: Fikizolo, Lisolomzi Assaph
- Date: 2021-10-29
- Subjects: Fishery management Africa, Southern , Fisheries Monitoring Africa, Southern , Fishery policy Africa, Southern , Fishery law and legislation Africa, Southern , South Africa. Fisheries Management Branch
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/190886 , vital:45038 , 10.21504/10962/190886
- Description: The responsibility of Fisheries Governance Authorities (FGAs) is to ensure that there is sustainable utilisation and exploitation of marine living resources through effective Monitoring, Control and Surveillance (MCS). MCS is a mechanism used to implement agreed policies, plans and strategies for oceans and fisheries governance, and it is key to their successful implementation. In the continent, the African Union (AU), through its agencies, economic and regional structures encourage and supports national and regional MCS programs. South Africa is a SADC coastal State with a fisheries governance branch mandated to ensure sustainable marine living resources’ utilisation with support from a national MCS program. This support depends on the effectiveness of the current national MCS organisational structure, capacity, legislative and policy framework, as well as regional cooperation. In addition to an extensive literature review, this study developed a MCS framework, following international fisheries legislation and guidelines, for testing the South African MCS’ conformity to such a model. Furthermore, Namibia and Mozambique were included as examples of SADC coastal States to determine their responsiveness to regional cooperation and coordination. Based on the framework, a questionnaire with four parts, Part A: Background Information; Part B: Evaluation of MCS Enablers; Part C: Evaluation of an MCS system process and its effectiveness – reactive approach; and Part D: - proactive approach was developed to collect information. The data was analysed, using appropriate statistical methods to determine, against set characteristics, the level of information that the government respondents could provide to the research topic, and to determine the effectiveness of the South African MCS program. Limited information from Namibia and Mozambique showed readiness in their respective MCS programs for a regional MCS integrated approach, as is the case with South Africa, but there is no serious engagement to implement any regional MCS program. Results showed that the South African MCS program's effectiveness is generally adequate, but there are challenges with planning; financial resources; MCS equipment; stakeholder engagement processes, and governance. A primary recommendation from this study was that business plans, as utilised in the private sector, should be developed by South African Fisheries Governance Authority (FGA) to address MCS governance shortcomings as revealed by this study. A reconfiguration of the MCS organisational structure to include a resource mobilisation unit is considered necessary to effect the much needed improvements. , Thesis (PhD) -- Faculty of Science, Geography, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Fikizolo, Lisolomzi Assaph
- Date: 2021-10-29
- Subjects: Fishery management Africa, Southern , Fisheries Monitoring Africa, Southern , Fishery policy Africa, Southern , Fishery law and legislation Africa, Southern , South Africa. Fisheries Management Branch
- Language: English
- Type: Doctoral theses , text
- Identifier: http://hdl.handle.net/10962/190886 , vital:45038 , 10.21504/10962/190886
- Description: The responsibility of Fisheries Governance Authorities (FGAs) is to ensure that there is sustainable utilisation and exploitation of marine living resources through effective Monitoring, Control and Surveillance (MCS). MCS is a mechanism used to implement agreed policies, plans and strategies for oceans and fisheries governance, and it is key to their successful implementation. In the continent, the African Union (AU), through its agencies, economic and regional structures encourage and supports national and regional MCS programs. South Africa is a SADC coastal State with a fisheries governance branch mandated to ensure sustainable marine living resources’ utilisation with support from a national MCS program. This support depends on the effectiveness of the current national MCS organisational structure, capacity, legislative and policy framework, as well as regional cooperation. In addition to an extensive literature review, this study developed a MCS framework, following international fisheries legislation and guidelines, for testing the South African MCS’ conformity to such a model. Furthermore, Namibia and Mozambique were included as examples of SADC coastal States to determine their responsiveness to regional cooperation and coordination. Based on the framework, a questionnaire with four parts, Part A: Background Information; Part B: Evaluation of MCS Enablers; Part C: Evaluation of an MCS system process and its effectiveness – reactive approach; and Part D: - proactive approach was developed to collect information. The data was analysed, using appropriate statistical methods to determine, against set characteristics, the level of information that the government respondents could provide to the research topic, and to determine the effectiveness of the South African MCS program. Limited information from Namibia and Mozambique showed readiness in their respective MCS programs for a regional MCS integrated approach, as is the case with South Africa, but there is no serious engagement to implement any regional MCS program. Results showed that the South African MCS program's effectiveness is generally adequate, but there are challenges with planning; financial resources; MCS equipment; stakeholder engagement processes, and governance. A primary recommendation from this study was that business plans, as utilised in the private sector, should be developed by South African Fisheries Governance Authority (FGA) to address MCS governance shortcomings as revealed by this study. A reconfiguration of the MCS organisational structure to include a resource mobilisation unit is considered necessary to effect the much needed improvements. , Thesis (PhD) -- Faculty of Science, Geography, 2021
- Full Text:
- Date Issued: 2021-10-29
The roots run deep?: Understanding branch politics within the African National Congress
- Authors: Mkhutle, Nhlanhla Handsome
- Date: 2021-10-29
- Subjects: African National Congress , Manipulative behavior Political aspects South Africa , Cartels South Africa , Power (Social sciences) South Africa , Patronage, Political South Africa , Political party organization South Africa , Branch politics
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190261 , vital:44978
- Description: This thesis explores the functioning of branch politics within the African National Congress (ANC) and the influence of branch politics on the organization and its structures. The ANC has many of the characteristics of a mass party. In mass parties, mass participation is supposed to be promoted through the activities of party branches. This thesis documents the weakening of the ANC’s local level structures and their political control over the organization’s decisions. ANC branches are investigated as democratic vanguards of ANC’s mass party persona, in relation to their functioning as the most basic units of the organization. The thesis reflects on branch members’ experiences in different ANC branches to understand the interplay between branch politics, political power, and patronage politics within the ANC. This research project also explores the possibility of manipulation of ANC branches by senior leaders and would-be-leaders of the ANC. The thesis then concludes by summarising the state of branch politics within the ANC and giving recommendations on further study with regards to branch politics of the ANC. , Thesis (MA) -- Faculty of Humanities, Political and International Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Mkhutle, Nhlanhla Handsome
- Date: 2021-10-29
- Subjects: African National Congress , Manipulative behavior Political aspects South Africa , Cartels South Africa , Power (Social sciences) South Africa , Patronage, Political South Africa , Political party organization South Africa , Branch politics
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/190261 , vital:44978
- Description: This thesis explores the functioning of branch politics within the African National Congress (ANC) and the influence of branch politics on the organization and its structures. The ANC has many of the characteristics of a mass party. In mass parties, mass participation is supposed to be promoted through the activities of party branches. This thesis documents the weakening of the ANC’s local level structures and their political control over the organization’s decisions. ANC branches are investigated as democratic vanguards of ANC’s mass party persona, in relation to their functioning as the most basic units of the organization. The thesis reflects on branch members’ experiences in different ANC branches to understand the interplay between branch politics, political power, and patronage politics within the ANC. This research project also explores the possibility of manipulation of ANC branches by senior leaders and would-be-leaders of the ANC. The thesis then concludes by summarising the state of branch politics within the ANC and giving recommendations on further study with regards to branch politics of the ANC. , Thesis (MA) -- Faculty of Humanities, Political and International Studies, 2021
- Full Text:
- Date Issued: 2021-10-29
Fabrication of gold-nanoparticle/conductive polymer composite materials: application to aptamer-based impedimetric biosensors for detection of histamine
- Authors: Ojo, Dupe Ruth
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192550 , vital:45236
- Description: Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Ojo, Dupe Ruth
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192550 , vital:45236
- Description: Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2021
- Full Text:
- Date Issued: 2021-10-29
Photosynthetic microbial fuel cells and fabricated photobioreactors applied with halotolerant microorganisms for nutrient and metal remediation under adverse hypersaline
- Authors: Smith, Galad Gilbert
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192561 , vital:45237
- Description: Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Smith, Galad Gilbert
- Date: 2021-10-29
- Subjects: Uncatalogued
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/192561 , vital:45237
- Description: Thesis (MSc) -- Faculty of Science, Biotechnology Innovation Centre, 2021
- Full Text:
- Date Issued: 2021-10-29
The Relationship between capital adequacy and profitability under Basel III in the Namibian banking sector
- Authors: Pomuti, Esther Kaulinawa
- Date: 2021-10-29
- Subjects: Banks and banking Namibia , Banks and banking, International Law and legislation , Bank capital Law and legislation Namibia , Rate of return Namibia , Basle Committee on Banking Supervision , Ratio analysis , Basel III (2010)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191909 , vital:45178
- Description: Globally, capital adequacy is one of the most central topics for both regulatory authorities and banks. It promotes stability and intends to reduce bank insolvency. It also represents the most important element of banks’ profitability (Profits are the first line of defense against losses from credit loss in a bank). After the collapse of Bretton Woods in 1973, many banks incurred large foreign currency losses, with Banks outside Germany having taken heavy losses on their unsettled trades with Herstatt Bank in Cologne, West Germany, when it collapsed in June 1974. This study empirically tests the relationship between changes in the capital adequacy ratio under Basel III and return on equity (ROE) of the Namibian banking sector and whether such relationships exist in the short run or long run. The study used panel quarterly data for a sample of three Namibian commercial banks from the year 1999 to 2019.It employed one panel unit root tests namely: Im, Pesaran and Shin W-stat (IPS). To test the existence of a long-run relationship (equilibrium) or effect between the dependent and independent variables, the study employed the Panel Co-integration methods using Pedroni and Kao (Engle-Granger based) tests. The study carried out the Hausman test to determine the best approach for analysis and determined the PMG approach to be the preferable model for analysis. Various diagnostic tests such as multicollinearity through the correlation analysis, autocorrelation, and heteroscedasticity and cross-sectional dependence tests were carried out to determine if the data set is well-modelled and if the results can be taken seriously. The study’s results under the PMG model showed that ROE and CAR have a positive significant relationship in the short run. A dummy variable to capture the connection between ROE and CAR before and after BASEL III shows that the relationship is positive and significant indicating that ROE increases more when there is capital regulation than when there is no capital regulation. The study also concluded that there is no long run relationship between CAR and ROE. Finally, the interaction effect between the dummy variable and CAR is negative but significant and thus indicating that the positive relationship does not persist post Basel III. , Thesis (MCom) -- Faculty of Commerce, Economics and Economic History, 2021
- Full Text:
- Date Issued: 2021-10-29
- Authors: Pomuti, Esther Kaulinawa
- Date: 2021-10-29
- Subjects: Banks and banking Namibia , Banks and banking, International Law and legislation , Bank capital Law and legislation Namibia , Rate of return Namibia , Basle Committee on Banking Supervision , Ratio analysis , Basel III (2010)
- Language: English
- Type: Master's theses , text
- Identifier: http://hdl.handle.net/10962/191909 , vital:45178
- Description: Globally, capital adequacy is one of the most central topics for both regulatory authorities and banks. It promotes stability and intends to reduce bank insolvency. It also represents the most important element of banks’ profitability (Profits are the first line of defense against losses from credit loss in a bank). After the collapse of Bretton Woods in 1973, many banks incurred large foreign currency losses, with Banks outside Germany having taken heavy losses on their unsettled trades with Herstatt Bank in Cologne, West Germany, when it collapsed in June 1974. This study empirically tests the relationship between changes in the capital adequacy ratio under Basel III and return on equity (ROE) of the Namibian banking sector and whether such relationships exist in the short run or long run. The study used panel quarterly data for a sample of three Namibian commercial banks from the year 1999 to 2019.It employed one panel unit root tests namely: Im, Pesaran and Shin W-stat (IPS). To test the existence of a long-run relationship (equilibrium) or effect between the dependent and independent variables, the study employed the Panel Co-integration methods using Pedroni and Kao (Engle-Granger based) tests. The study carried out the Hausman test to determine the best approach for analysis and determined the PMG approach to be the preferable model for analysis. Various diagnostic tests such as multicollinearity through the correlation analysis, autocorrelation, and heteroscedasticity and cross-sectional dependence tests were carried out to determine if the data set is well-modelled and if the results can be taken seriously. The study’s results under the PMG model showed that ROE and CAR have a positive significant relationship in the short run. A dummy variable to capture the connection between ROE and CAR before and after BASEL III shows that the relationship is positive and significant indicating that ROE increases more when there is capital regulation than when there is no capital regulation. The study also concluded that there is no long run relationship between CAR and ROE. Finally, the interaction effect between the dummy variable and CAR is negative but significant and thus indicating that the positive relationship does not persist post Basel III. , Thesis (MCom) -- Faculty of Commerce, Economics and Economic History, 2021
- Full Text:
- Date Issued: 2021-10-29