Transport and General Workers Union: congress report financial progress report for period July 1988 to November 1989
- Transport and General Workers' Union (South Africa)
- Authors: Transport and General Workers' Union (South Africa)
- Date: 1989-07
- Subjects: Uncatalogued
- Language: eng
- Type: text , pamphlet
- Identifier: http://hdl.handle.net/10962/103428 , vital:32245
- Description: In reviewing the developments in T&G finances over the past eighteen months, we can safely say that T&G finances have certainly stabilized over the period. However, in case we get too excited at this news, a note of caution. While our income from subscriptions has steadily improved, due mainly to the Congress ’88 increase in rate (from R3 to R4); our expenditure has in relation also increased to the point that if we continue with our current expenditure pace of October ’89 and November 89, we will soon return to our previous problem of constant threat of bank overdraft! We are a long way off self-sufficiency and still rely heavily on our overseas funders for assistance in the areas of legal fees and our education programme. This report will focus on both the positive developments in T&G finances over these past eighteen months, as well as the problem areas which we need to seriously tackle from here!
- Full Text:
- Date Issued: 1989-07
- Authors: Transport and General Workers' Union (South Africa)
- Date: 1989-07
- Subjects: Uncatalogued
- Language: eng
- Type: text , pamphlet
- Identifier: http://hdl.handle.net/10962/103428 , vital:32245
- Description: In reviewing the developments in T&G finances over the past eighteen months, we can safely say that T&G finances have certainly stabilized over the period. However, in case we get too excited at this news, a note of caution. While our income from subscriptions has steadily improved, due mainly to the Congress ’88 increase in rate (from R3 to R4); our expenditure has in relation also increased to the point that if we continue with our current expenditure pace of October ’89 and November 89, we will soon return to our previous problem of constant threat of bank overdraft! We are a long way off self-sufficiency and still rely heavily on our overseas funders for assistance in the areas of legal fees and our education programme. This report will focus on both the positive developments in T&G finances over these past eighteen months, as well as the problem areas which we need to seriously tackle from here!
- Full Text:
- Date Issued: 1989-07
Types of case study work : a conceptual framework for case-based research
- Authors: Edwards, D J A
- Date: 1998
- Language: English
- Type: Article
- Identifier: vital:6240 , http://hdl.handle.net/10962/d1007852
- Description: This paper describes a conceptual framework for understanding the phases of casebased research. Case-based strategies in research are widely used in case study methodology as well as in a number of qualitative methodologies including grounded theory development, phenomenological research method and psychotherapy process research. The epistemological principles upon which casebased research is based are fundamentally different those which inform groupbased research using quantitative multivariate statistics. The case-based research process is divided into three general phases: descriptive, theoretical-heuristic, and theory-testing. Each of these phases is subdivided into two categories. The aims and epistemological principles related to each phase are discussed and illustrated with examples from contemporary research. The principles for establishing validity in case-base research are also reviewed and, in order to assist research students and supervisors, some common pitfalls are noted. The paper shows that rigorous work with single cases or series of cases using case-based principles and methodology is indeed, as Bromley (1986) claimed, "the bedrock of scientific investigation".
- Full Text:
- Date Issued: 1998
- Authors: Edwards, D J A
- Date: 1998
- Language: English
- Type: Article
- Identifier: vital:6240 , http://hdl.handle.net/10962/d1007852
- Description: This paper describes a conceptual framework for understanding the phases of casebased research. Case-based strategies in research are widely used in case study methodology as well as in a number of qualitative methodologies including grounded theory development, phenomenological research method and psychotherapy process research. The epistemological principles upon which casebased research is based are fundamentally different those which inform groupbased research using quantitative multivariate statistics. The case-based research process is divided into three general phases: descriptive, theoretical-heuristic, and theory-testing. Each of these phases is subdivided into two categories. The aims and epistemological principles related to each phase are discussed and illustrated with examples from contemporary research. The principles for establishing validity in case-base research are also reviewed and, in order to assist research students and supervisors, some common pitfalls are noted. The paper shows that rigorous work with single cases or series of cases using case-based principles and methodology is indeed, as Bromley (1986) claimed, "the bedrock of scientific investigation".
- Full Text:
- Date Issued: 1998
Understanding the Pyrimethamine drug resistance mechanism via combined molecular dynamics and dynamic residue network analysis:
- Amusengeri, Arnold, Tata, Rolland B, Tastan Bishop, Özlem
- Authors: Amusengeri, Arnold , Tata, Rolland B , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163022 , vital:41005 , https://doi.org/10.3390/molecules25040904
- Description: In this era of precision medicine, insights into the resistance mechanism of drugs are integral for the development of potent therapeutics. Here, we sought to understand the contribution of four point mutations (N51I, C59R, S108N, and I164L) within the active site of the malaria parasite enzyme dihydrofolate reductase (DHFR) towards the resistance of the antimalarial drug pyrimethamine. Homology modeling was used to obtain full-length models of wild type (WT) and mutant DHFR. Molecular docking was employed to dock pyrimethamine onto the generated structures. Subsequent all-atom molecular dynamics (MD) simulations and binding free-energy computations highlighted that pyrimethamine’s stability and affinity inversely relates to the number of mutations within its binding site and, hence, resistance severity.
- Full Text:
- Date Issued: 2020
- Authors: Amusengeri, Arnold , Tata, Rolland B , Tastan Bishop, Özlem
- Date: 2020
- Language: English
- Type: text , article
- Identifier: http://hdl.handle.net/10962/163022 , vital:41005 , https://doi.org/10.3390/molecules25040904
- Description: In this era of precision medicine, insights into the resistance mechanism of drugs are integral for the development of potent therapeutics. Here, we sought to understand the contribution of four point mutations (N51I, C59R, S108N, and I164L) within the active site of the malaria parasite enzyme dihydrofolate reductase (DHFR) towards the resistance of the antimalarial drug pyrimethamine. Homology modeling was used to obtain full-length models of wild type (WT) and mutant DHFR. Molecular docking was employed to dock pyrimethamine onto the generated structures. Subsequent all-atom molecular dynamics (MD) simulations and binding free-energy computations highlighted that pyrimethamine’s stability and affinity inversely relates to the number of mutations within its binding site and, hence, resistance severity.
- Full Text:
- Date Issued: 2020