Factors impeding African immigrant entrepreneurs’ progression in selected small and medium enterprises: Evidence from a local municipality in South Africa
- Bernard L. Ngota, Eric E. Mang’unyi, Sookdhev Rajkaran
- Authors: Bernard L. Ngota , Eric E. Mang’unyi , Sookdhev Rajkaran
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4743 , vital:44174
- Full Text:
- Authors: Bernard L. Ngota , Eric E. Mang’unyi , Sookdhev Rajkaran
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4743 , vital:44174
- Full Text:
Factors associated with glycemic control among South African adult residents of Mkhondo municipality living with diabetes mellitus
- Charity Masilela, Oladele Vincent Adeniy, Brendon Pearce, Joven Jebio Ongole, Mongi Benjeddou
- Authors: Charity Masilela , Oladele Vincent Adeniy , Brendon Pearce , Joven Jebio Ongole , Mongi Benjeddou
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4642 , vital:44148
- Full Text:
- Authors: Charity Masilela , Oladele Vincent Adeniy , Brendon Pearce , Joven Jebio Ongole , Mongi Benjeddou
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4642 , vital:44148
- Full Text:
Exploring national human resource profile and trends of Prosthetists/ Orthotists in South Africa from 2002 to 2018
- Luphiwo Mduzana, Ritika Tiwari, Ned Lieketseng, Usuf Chikte
- Authors: Luphiwo Mduzana , Ritika Tiwari, Ned Lieketseng , Usuf Chikte
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4618 , vital:44143
- Full Text:
- Authors: Luphiwo Mduzana , Ritika Tiwari, Ned Lieketseng , Usuf Chikte
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4618 , vital:44143
- Full Text:
Evaluation of Intussusception After Oral Monovalent Rotavirus Vaccination in South Africa
- Michelle J. Groome, Nick Andrews, Jacqueline E. Tate, Marion Arnold, Milind Chitnis, Sharon Cox, Corné de Vos, Mari Kirsten, Susanna M. le Grange, Jerome Loveland, Sello Machaea, Ashwini Maharaj, Shabir A. Madhi, Umesh D. Parashar
- Authors: Michelle J. Groome , Nick Andrews , Jacqueline E. Tate , Marion Arnold , Milind Chitnis , Sharon Cox , Corné de Vos , Mari Kirsten , Susanna M. le Grange , Jerome Loveland , Sello Machaea , Ashwini Maharaj , Shabir A. Madhi , Umesh D. Parashar
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4543 , vital:44131
- Full Text:
- Authors: Michelle J. Groome , Nick Andrews , Jacqueline E. Tate , Marion Arnold , Milind Chitnis , Sharon Cox , Corné de Vos , Mari Kirsten , Susanna M. le Grange , Jerome Loveland , Sello Machaea , Ashwini Maharaj , Shabir A. Madhi , Umesh D. Parashar
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4543 , vital:44131
- Full Text:
Diurnal variation of steroid hormones and their reference intervals using mass spectrometric analysis
- Parikh, T P, Stolze, B, Ozarda, Y, Jonklaas, J, Welsh, K, Masika, L, Hill, M, DeCherney, A, Soldin, S J
- Authors: Parikh, T P , Stolze, B , Ozarda, Y , Jonklaas, J , Welsh, K , Masika, L , Hill, M , DeCherney, A , Soldin, S J
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/5224 , vital:44411
- Full Text:
- Authors: Parikh, T P , Stolze, B , Ozarda, Y , Jonklaas, J , Welsh, K , Masika, L , Hill, M , DeCherney, A , Soldin, S J
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/5224 , vital:44411
- Full Text:
Distorted, Relegated and Colonised: Reconceptualising Ogun as the God of Justice in Sunnie Ododo’s Hard Choice
- Enongene Mirabeau Sone, Olutoba Gboyega Oluwasuji
- Authors: Enongene Mirabeau Sone , Olutoba Gboyega Oluwasuji
- Date: 2019
- Subjects: Ogun; coloniality; decolonial turn; Yoruba mythology; Nigeria
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/2648 , vital:42308
- Description: The effort to name and ascribe duties to African gods using Eurocentric knowledge can lead to violence, hence causing them to be tagged negatively. Due to the imperial distortion of African history, the people were made to believe that they need civilisation, salvation, and reconstruction. The colonisers had to convince Africans that all that emanated from the continent was filled with ‘darkness’ and therefore needed to be civilised, reconstructed and humanised by Europe. African myths and religions suffer from this deceptive move by the Europeans and the gods are often relegated to being wicked and unjust. In this paper, which attempts to correct such erroneous beliefs, the focus is on Ogun, the Yoruba god of war, who has been subjected to mistaken identity by scholars, researchers and critics. It is against this backdrop and misrepresentation of Ogun that the authors delink from the notion that the god is a vengeful and obstinate god. They conclude that Ogun is not a god who engages in reckless devastation of life, as is commonly argued in literature criticisms of the Ogun figure, but a god who seeks justice when wronged. Decolonial thought and its view on ‘unthinking’ Eurocentric epistemologies on Africa are used to unpack Ogun’s characteristics as a god of justice in Ododo’s Hard Choice.
- Full Text:
- Authors: Enongene Mirabeau Sone , Olutoba Gboyega Oluwasuji
- Date: 2019
- Subjects: Ogun; coloniality; decolonial turn; Yoruba mythology; Nigeria
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/2648 , vital:42308
- Description: The effort to name and ascribe duties to African gods using Eurocentric knowledge can lead to violence, hence causing them to be tagged negatively. Due to the imperial distortion of African history, the people were made to believe that they need civilisation, salvation, and reconstruction. The colonisers had to convince Africans that all that emanated from the continent was filled with ‘darkness’ and therefore needed to be civilised, reconstructed and humanised by Europe. African myths and religions suffer from this deceptive move by the Europeans and the gods are often relegated to being wicked and unjust. In this paper, which attempts to correct such erroneous beliefs, the focus is on Ogun, the Yoruba god of war, who has been subjected to mistaken identity by scholars, researchers and critics. It is against this backdrop and misrepresentation of Ogun that the authors delink from the notion that the god is a vengeful and obstinate god. They conclude that Ogun is not a god who engages in reckless devastation of life, as is commonly argued in literature criticisms of the Ogun figure, but a god who seeks justice when wronged. Decolonial thought and its view on ‘unthinking’ Eurocentric epistemologies on Africa are used to unpack Ogun’s characteristics as a god of justice in Ododo’s Hard Choice.
- Full Text:
Diagnostic performance of several biomarkers for identification of cases of non-communicable diseases among Central Africans
- Charles Bitamazire Businge, Benjamin Longo-Mbenza, Oladele Vincent Adeniyi, Moise Mvitu Muaka, Georges Mvumbi Lelo, Mireille Solange Nganga Nkanga, Jean-Marie Kavembe, Baudoin Buassa-bu-Tsumbu, Jean-Rene’ M’buyamba Kabangu, Daniel Ter Goon
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Oladele Vincent Adeniyi , Moise Mvitu Muaka , Georges Mvumbi Lelo , Mireille Solange Nganga Nkanga , Jean-Marie Kavembe , Baudoin Buassa-bu-Tsumbu , Jean-Rene’ M’buyamba Kabangu , Daniel Ter Goon
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4845 , vital:44292
- Full Text:
- Authors: Charles Bitamazire Businge , Benjamin Longo-Mbenza , Oladele Vincent Adeniyi , Moise Mvitu Muaka , Georges Mvumbi Lelo , Mireille Solange Nganga Nkanga , Jean-Marie Kavembe , Baudoin Buassa-bu-Tsumbu , Jean-Rene’ M’buyamba Kabangu , Daniel Ter Goon
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4845 , vital:44292
- Full Text:
Detection of extended spectrum beta‑lactamase genes in Pseudomonas aeruginosa isolated from patients in rural Eastern Cape Province, South Africa
- Mojisola C. Hosu, Sandeep D. Vasaikar,, Grace E. Okuthe, Teke Apalata
- Authors: Mojisola C. Hosu , Sandeep D. Vasaikar, , Grace E. Okuthe , Teke Apalata
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4509 , vital:44128
- Description: The proliferation of extended spectrum beta-lactamase (ESBL) producing Pseudomonas aeruginosa represent a major public health threat. In this study, we evaluated the antimicrobial resistance patterns of P. aeruginosa strains and characterized the ESBLs and Metallo- β-lactamases (MBL) produced. Strains of P. aeruginosa cultured from patients who attended Nelson Mandela Academic Hospital and other clinics in the four district municipalities of the Eastern Cape between August 2017 and May 2019 were identified; antimicrobial susceptibility testing was carried out against thirteen clinically relevant antibiotics using the BioMérieux VITEK 2 and confirmed by Beckman autoSCAN-4 System. Real-time PCR was done using Roche Light Cycler 2.0 to detect the presence of ESBLs; blaSHV, blaTEM and blaCTX-M genes; and MBLs; blaIMP, blaVIM. Strains of P. aeruginosa demonstrated resistance to wide-ranging clinically relevant antibiotics including piperacillin (64.2%), followed by aztreonam (57.8%), cefepime (51.5%), ceftazidime (51.0%), piperacillin/tazobactam (50.5%), and imipenem (46.6%). A total of 75 (36.8%) multidrug-resistant (MDR) strains were observed of the total pool of isolates. The blaTEM, blaSHV and blaCTX-M was detected in 79.3%, 69.5% and 31.7% isolates (n = 82), respectively. The blaIMP was detected in 1.25% while no blaVIM was detected in any of the strains tested. The study showed a high rate of MDR P. aeruginosa in our setting. The vast majority of these resistant strains carried blaTEM and blaSHV genes. Continuous monitoring of antimicrobial resistance and strict compliance towards infection prevention and control practices are the best defence against spread of MDR P. aeruginosa.
- Full Text:
- Authors: Mojisola C. Hosu , Sandeep D. Vasaikar, , Grace E. Okuthe , Teke Apalata
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4509 , vital:44128
- Description: The proliferation of extended spectrum beta-lactamase (ESBL) producing Pseudomonas aeruginosa represent a major public health threat. In this study, we evaluated the antimicrobial resistance patterns of P. aeruginosa strains and characterized the ESBLs and Metallo- β-lactamases (MBL) produced. Strains of P. aeruginosa cultured from patients who attended Nelson Mandela Academic Hospital and other clinics in the four district municipalities of the Eastern Cape between August 2017 and May 2019 were identified; antimicrobial susceptibility testing was carried out against thirteen clinically relevant antibiotics using the BioMérieux VITEK 2 and confirmed by Beckman autoSCAN-4 System. Real-time PCR was done using Roche Light Cycler 2.0 to detect the presence of ESBLs; blaSHV, blaTEM and blaCTX-M genes; and MBLs; blaIMP, blaVIM. Strains of P. aeruginosa demonstrated resistance to wide-ranging clinically relevant antibiotics including piperacillin (64.2%), followed by aztreonam (57.8%), cefepime (51.5%), ceftazidime (51.0%), piperacillin/tazobactam (50.5%), and imipenem (46.6%). A total of 75 (36.8%) multidrug-resistant (MDR) strains were observed of the total pool of isolates. The blaTEM, blaSHV and blaCTX-M was detected in 79.3%, 69.5% and 31.7% isolates (n = 82), respectively. The blaIMP was detected in 1.25% while no blaVIM was detected in any of the strains tested. The study showed a high rate of MDR P. aeruginosa in our setting. The vast majority of these resistant strains carried blaTEM and blaSHV genes. Continuous monitoring of antimicrobial resistance and strict compliance towards infection prevention and control practices are the best defence against spread of MDR P. aeruginosa.
- Full Text:
Detection of a SARS-CoV-2 variant of concern in South Africa
- Authors: Oluwakemi Laguda-Akingba
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4505 , vital:44127
- Description: Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance3–5. This lineage was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province. This lineage spread rapidly, and became dominant in Eastern Cape, Western Cape and KwaZulu– Natal provinces within weeks. Although the full import of the mutations is yet to be determined, the genomic data—which show rapid expansion and displacement of other lineages in several regions—suggest that this lineage is associated with a selection advantage that most plausibly results from increased transmissibility or immune escape6–8.
- Full Text:
- Authors: Oluwakemi Laguda-Akingba
- Date: 2021
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4505 , vital:44127
- Description: Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance3–5. This lineage was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province. This lineage spread rapidly, and became dominant in Eastern Cape, Western Cape and KwaZulu– Natal provinces within weeks. Although the full import of the mutations is yet to be determined, the genomic data—which show rapid expansion and displacement of other lineages in several regions—suggest that this lineage is associated with a selection advantage that most plausibly results from increased transmissibility or immune escape6–8.
- Full Text:
Decreased total antioxidant levels and increased oxidative stress in South African type 2 diabetes mellitus patients
- FA Ganjifrockwala, JT Joseph, G George
- Authors: FA Ganjifrockwala , JT Joseph , G George
- Date: 2017
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/3686 , vital:43925
- Full Text:
- Authors: FA Ganjifrockwala , JT Joseph , G George
- Date: 2017
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/3686 , vital:43925
- Full Text:
Dataset and ANN model prediction of performance of graphene nanolubricant with R600a in domestic refrigerator system
- T.O. Babarinde a, S.A. Akinlabi, D.M. Madyira, F.M. Ekundayo, P.A. Adedeji
- Authors: T.O. Babarinde a , S.A. Akinlabi , D.M. Madyira , F.M. Ekundayo , P.A. Adedeji
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4144 , vital:44030
- Full Text:
- Authors: T.O. Babarinde a , S.A. Akinlabi , D.M. Madyira , F.M. Ekundayo , P.A. Adedeji
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4144 , vital:44030
- Full Text:
Data on microhardness and structural analysis of friction stir spot welded lap joints of AA5083-H116
- Esther T. Akinlabi, Ayuba S. Osinubi, Nkosinathi Madushele, Stephen A. Akinlabi, Omolayo M. Ikumapayi
- Authors: Esther T. Akinlabi , Ayuba S. Osinubi , Nkosinathi Madushele , Stephen A. Akinlabi , Omolayo M. Ikumapayi
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4168 , vital:44034
- Full Text:
Data on microhardness and structural analysis of friction stir spot welded lap joints of AA5083-H116
- Authors: Esther T. Akinlabi , Ayuba S. Osinubi , Nkosinathi Madushele , Stephen A. Akinlabi , Omolayo M. Ikumapayi
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4168 , vital:44034
- Full Text:
Data on microhardness and structural analysis of friction stir spot welded lap joints of AA5083-H116
- Esther T. Akinlabi, Ayuba S. Osinubi, Nkosinathi Madushele, Stephen A. Akinlabi, M. Ikumapayi
- Authors: Esther T. Akinlabi , Ayuba S. Osinubi , Nkosinathi Madushele , Stephen A. Akinlabi , M. Ikumapayi
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/3801 , vital:43949
- Full Text:
Data on microhardness and structural analysis of friction stir spot welded lap joints of AA5083-H116
- Authors: Esther T. Akinlabi , Ayuba S. Osinubi , Nkosinathi Madushele , Stephen A. Akinlabi , M. Ikumapayi
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/3801 , vital:43949
- Full Text:
Cross-sectional study of diabetes kidney disease in the Eastern Cape, South Africa
- Oladele Vincent Adeniyi, Eyitayo Omolara Owolabi
- Authors: Oladele Vincent Adeniyi , Eyitayo Omolara Owolabi
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4569 , vital:44134
- Full Text:
- Authors: Oladele Vincent Adeniyi , Eyitayo Omolara Owolabi
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4569 , vital:44134
- Full Text:
Corrigendum to “Perinatal maternal depression in rural South Africa: Child outcomes over the first two years”. Journal of Affective Disorders, 247 (2019) 168-174
- Joan Christodoulou, Karl Le Roux, Mark Tomlinson, Ingrid M. Le Roux, Linnea Stansert Katzen, Mary Jane Rotheram-Borus
- Authors: Joan Christodoulou , Karl Le Roux , Mark Tomlinson , Ingrid M. Le Roux , Linnea Stansert Katzen , Mary Jane Rotheram-Borus
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4136 , vital:44029
- Full Text:
- Authors: Joan Christodoulou , Karl Le Roux , Mark Tomlinson , Ingrid M. Le Roux , Linnea Stansert Katzen , Mary Jane Rotheram-Borus
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4136 , vital:44029
- Full Text:
Conditional economic incentives to improve HIV prevention
- Mark K U Pasayan, Adeyinka A Alab, Douglas F Nixon
- Authors: Mark K U Pasayan , Adeyinka A Alab , Douglas F Nixon
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4723 , vital:44169
- Full Text:
- Authors: Mark K U Pasayan , Adeyinka A Alab , Douglas F Nixon
- Date: 2020
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4723 , vital:44169
- Full Text:
Comprehensive data on the mechanical properties and biodegradation profile of polylactide composites developed for hard tissue repairs
- Abraham K. Aworinde, Samson O. Adeosun, Festus A. Oyawale, Eyere Emagbetere, Felix A. Ishola, Obafemi Olatunji, Stephen A. Akinlab, Sunday O. Oyedepo, Oluseyi O. Ajayi, Esther T. Akinlabi
- Authors: Abraham K. Aworinde , Samson O. Adeosun , Festus A. Oyawale , Eyere Emagbetere , Felix A. Ishola , Obafemi Olatunji , Stephen A. Akinlab , Sunday O. Oyedepo , Oluseyi O. Ajayi , Esther T. Akinlabi
- Date: 2020
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4152 , vital:44032
- Full Text:
- Authors: Abraham K. Aworinde , Samson O. Adeosun , Festus A. Oyawale , Eyere Emagbetere , Felix A. Ishola , Obafemi Olatunji , Stephen A. Akinlab , Sunday O. Oyedepo , Oluseyi O. Ajayi , Esther T. Akinlabi
- Date: 2020
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4152 , vital:44032
- Full Text:
Clinical and demographic profile of catatonic patients who received electroconvulsive therapy in a South African setting
- Kavendren Odayar, Ingrid Elof, Willem Esterhuysen
- Authors: Kavendren Odayar , Ingrid Elof , Willem Esterhuysen
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4719 , vital:44168
- Full Text:
- Authors: Kavendren Odayar , Ingrid Elof , Willem Esterhuysen
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4719 , vital:44168
- Full Text:
Change in renal function post-nephrectomy for renal cell carcinoma in patients with and without hypertension and/or diabetes
- John, J, Henry, M, Ringoir, A, Pinto, G, Kesner, K, Lazarus, J, Sinha, S
- Authors: John, J , Henry, M , Ringoir, A , Pinto, G , Kesner, K , Lazarus, J , Sinha, S
- Date: 2020
- Subjects: RCC, Nephrectomy, eGFR, CKD
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/6368 , vital:45380
- Description: BACKGROUND: The standard of care for surgically resectable disease renal cell carcinoma (RCC) is a nephrectomy. Post nephrectomy, these patients are at risk for the development of new onset chronic kidney disease or the progression of pre-existing chronic kidney disease. We aimed to report the changes in renal function in patients who had a nephrectomy for RCC METHODS: This retrospective, descriptive, cross-sectional study identified 137 patients who had a nephrectomy for RCC from 1 January 2009 to 31 December 2017. The pre-nephrectomy and post-nephrectomy estimated glomerular filtration rate (eGFR) and the histological subtype of RCC on histopathological analysis of the resected specimen were recorded from the National Health Laboratory Services online results platform. All analyses were conducted using SPSS (Version 25) and the significance level was set at p < 0.05 RESULTS: After a mean follow-up period of 26.5 ± 22 months (median = 19 months), the patients' eGFR dropped by a mean of 4.82 ± 8.67 ml/min/1.73 m2 (95% CI 3.23-6.41) post-nephrectomy. The mean eGFR fall in patients' who had hypertension and/or diabetes (n = 63) was significantly larger compared to patients who had neither of these comorbidities (n = 54; p < .001; mean = 7.30 ± 8.40 ml/min/1.73 m2 (95% CI 5.19-9.42) and 1.93 ± 8.14 ml/min/1.73 m2 (95% CI 0.30-4.15) respectively CONCLUSIONS: The decline in renal function in patients with hypertension and/or diabetes mellitus is more pronounced than in patients with neither of these comorbidities. In these high-risk patients, measures must be taken to prevent the development and limit the progression of chronic kidney disease
- Full Text:
- Authors: John, J , Henry, M , Ringoir, A , Pinto, G , Kesner, K , Lazarus, J , Sinha, S
- Date: 2020
- Subjects: RCC, Nephrectomy, eGFR, CKD
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/6368 , vital:45380
- Description: BACKGROUND: The standard of care for surgically resectable disease renal cell carcinoma (RCC) is a nephrectomy. Post nephrectomy, these patients are at risk for the development of new onset chronic kidney disease or the progression of pre-existing chronic kidney disease. We aimed to report the changes in renal function in patients who had a nephrectomy for RCC METHODS: This retrospective, descriptive, cross-sectional study identified 137 patients who had a nephrectomy for RCC from 1 January 2009 to 31 December 2017. The pre-nephrectomy and post-nephrectomy estimated glomerular filtration rate (eGFR) and the histological subtype of RCC on histopathological analysis of the resected specimen were recorded from the National Health Laboratory Services online results platform. All analyses were conducted using SPSS (Version 25) and the significance level was set at p < 0.05 RESULTS: After a mean follow-up period of 26.5 ± 22 months (median = 19 months), the patients' eGFR dropped by a mean of 4.82 ± 8.67 ml/min/1.73 m2 (95% CI 3.23-6.41) post-nephrectomy. The mean eGFR fall in patients' who had hypertension and/or diabetes (n = 63) was significantly larger compared to patients who had neither of these comorbidities (n = 54; p < .001; mean = 7.30 ± 8.40 ml/min/1.73 m2 (95% CI 5.19-9.42) and 1.93 ± 8.14 ml/min/1.73 m2 (95% CI 0.30-4.15) respectively CONCLUSIONS: The decline in renal function in patients with hypertension and/or diabetes mellitus is more pronounced than in patients with neither of these comorbidities. In these high-risk patients, measures must be taken to prevent the development and limit the progression of chronic kidney disease
- Full Text:
Body dysmorphic disorder: A diagnostic challenge in adolescence
- Thungana, Yanga, Moxley, Karis, Lachman, Anusha
- Authors: Thungana, Yanga , Moxley, Karis , Lachman, Anusha
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4831 , vital:44284
- Full Text:
- Authors: Thungana, Yanga , Moxley, Karis , Lachman, Anusha
- Date: 2018
- Language: English
- Type: Journal Article
- Identifier: http://hdl.handle.net/11260/4831 , vital:44284
- Full Text: