https://vital.seals.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 Phenylpropanolamine hydrochloride https://vital.seals.ac.za/vital/access/manager/Repository/vital:6385 Wed 12 May 2021 20:37:04 SAST ]]> Generic substitution: the use of medicinal products containing different salts and implications for safety and efficacy https://vital.seals.ac.za/vital/access/manager/Repository/vital:6445 Wed 12 May 2021 20:17:28 SAST ]]> Evaluation of the proposed FDA pilot-dose response methodology for topical corticosteroid bioequivalence testing https://vital.seals.ac.za/vital/access/manager/Repository/vital:6356 0.95) was noted for both methods of assessment. The chromameter ED[subscript 50] values determined in this study were approximately 2 hours for both preparations. At this dose duration the instrument would not be sensitive enough to distinguish between weak blanching responses and normal skin for bioequivalence assessment purposes.]]> Wed 12 May 2021 20:14:50 SAST ]]> The human skin-blanching assay for in vitro topical corticosteroid assessment. I. Reproducibility of the assay https://vital.seals.ac.za/vital/access/manager/Repository/vital:6381 Wed 12 May 2021 19:07:40 SAST ]]> An LC-MS-MS method for the determination of cyclizine in human serum https://vital.seals.ac.za/vital/access/manager/Repository/vital:6408 Wed 12 May 2021 19:05:50 SAST ]]> Rapid UPLC - MS/MS method for the determination of ketoprofen in human dermal microdialysis samples https://vital.seals.ac.za/vital/access/manager/Repository/vital:6444 209.00 and 205.00 > 161.00, respectively. Calibration curves were linear over the range 0.5–500 ng/ml with correlation coefficients > 0.999. The accuracy and precision of the method were found to be between 99.97% and 104.67% (R.S.D. < 2%) and the mean recovery of KET from normal saline was 88.03 ± 0.3% (R.S.D. < 2.20%). The LLOQ and LOD values were found to be 0.5 and 0.1 ng/ml respectively whereas the ULOD was set at 500 ng/ml. The method was successfully applied to determine the bioavailability of KET following application of topical KET gel, Fastum® gel, to the skin of human volunteers.]]> Wed 12 May 2021 18:49:51 SAST ]]> Potency ranking of two new topical corticosteroid creams containing 0.1% desonide or 0.05% halometasone utilizing the human skin-blanching assay https://vital.seals.ac.za/vital/access/manager/Repository/vital:6400 Wed 12 May 2021 18:33:39 SAST ]]> Analysis of macrolide antibiotics https://vital.seals.ac.za/vital/access/manager/Repository/vital:7011 Wed 12 May 2021 18:24:35 SAST ]]> In vitro-in vivo evaluation of a sustained release phenylpropanolamine oral dosage form https://vital.seals.ac.za/vital/access/manager/Repository/vital:6360 Wed 12 May 2021 18:24:11 SAST ]]> Sterols and sterolins in Hypoxis hemerocallidea (African potato) https://vital.seals.ac.za/vital/access/manager/Repository/vital:6417 Wed 12 May 2021 18:04:06 SAST ]]> Determination of phenylpropanolamine in serum and urine by high performance liquid chromatography https://vital.seals.ac.za/vital/access/manager/Repository/vital:6361 Wed 12 May 2021 17:18:51 SAST ]]> A capillary zone electrophoresis (CZE) method for the determination of cyclizine hydrochloride in tablets and suppositories https://vital.seals.ac.za/vital/access/manager/Repository/vital:6406 Wed 12 May 2021 17:15:47 SAST ]]> Rapid method for the quantitative determination of efavirenz in human plasma https://vital.seals.ac.za/vital/access/manager/Repository/vital:6388 Wed 12 May 2021 16:51:06 SAST ]]> Interactions between steroidal anti-inflammatory agents and collagen https://vital.seals.ac.za/vital/access/manager/Repository/vital:3849 Wed 12 May 2021 16:29:13 SAST ]]> Assessment of topical corticosteroid preparations: the human skin-blanching assay https://vital.seals.ac.za/vital/access/manager/Repository/vital:6374 Wed 12 May 2021 16:12:28 SAST ]]> Bioequivalence assessment of generic products an innovative South African approach https://vital.seals.ac.za/vital/access/manager/Repository/vital:44194 Thu 19 Aug 2021 14:23:27 SAST ]]> Application of reverse-flow micellar electrokinetic chromatography for the simultaneous determination of flavonols and terpene trilactones in Ginkgo biloba dosage forms https://vital.seals.ac.za/vital/access/manager/Repository/vital:6357 -cyclodextrin concentrations were investigated. A polyimide fused-silica square capillary column (75 μm I.D. × 360 μm O.D.) with a total length of 60.0 cm and effective length of 45.0 cm was used for the separation. The final BGE consisted of 20 mM phosphoric acid, 40 mM SDS and 12 mM -cyclodextrin (pH 2.2) using reverse polarity with a voltage of −17.5 kV. Samples were injected electrokinetically at −5 kV for 3 s for the qualitative analysis and hydrodynamically at 20 mbar for 0.6 s for the quantitative assay. The total run time was 22 min and the limits of detection were 3.13 μg/ml and 1.88 μg/ml for rutin and quercetin, respectively. Fingerprint profiles of the solid oral dosage forms and the results of the quantitative analysis indicated that there were major discrepancies in the marker content between products and illustrates the value of this method for use as a procedure to assess product quality of commercially available Ginkgo biloba products.]]> Thu 15 Jul 2021 21:30:37 SAST ]]> Comparison of the blanching activities of Dermovate, Betnovate and Eumovate creams and ointments https://vital.seals.ac.za/vital/access/manager/Repository/vital:6393 Thu 15 Jul 2021 21:30:36 SAST ]]> The release of betamethasone 17-valerate from extemporaneous dilutions of a proprietary topical cream https://vital.seals.ac.za/vital/access/manager/Repository/vital:6397 Thu 15 Jul 2021 21:30:36 SAST ]]> Assessment of some variables affecting the blanching activity of betamethasone 17-valerate cream https://vital.seals.ac.za/vital/access/manager/Repository/vital:6396 Thu 15 Jul 2021 21:30:35 SAST ]]> Comparative blanching activities of proprietary diflucortolone valerate topical preparations https://vital.seals.ac.za/vital/access/manager/Repository/vital:6350 Thu 15 Jul 2021 21:30:34 SAST ]]> A stability-indicating liquid chromatographic method for the analysis of erythromycin in stored biological fluids using amperometric detection https://vital.seals.ac.za/vital/access/manager/Repository/vital:6430 Thu 15 Jul 2021 21:23:34 SAST ]]> African herbal medicines in the treatment of HIV: Hypoxis and Sutherlandia: an overview of evidence and pharmacology https://vital.seals.ac.za/vital/access/manager/Repository/vital:6401 Thu 15 Jul 2021 21:23:34 SAST ]]> Determination of erythromycin in serum and urine by high performance liquid chromatography with ultraviolet detection https://vital.seals.ac.za/vital/access/manager/Repository/vital:6428 Thu 15 Jul 2021 21:23:34 SAST ]]> High performance liquid chromatographic analysis of oleandomycin in serum and urine https://vital.seals.ac.za/vital/access/manager/Repository/vital:6429 Thu 15 Jul 2021 21:23:34 SAST ]]> Comparative blanching activities of some topical corticosteroid containing lotions https://vital.seals.ac.za/vital/access/manager/Repository/vital:6398 Thu 13 May 2021 08:13:33 SAST ]]> Evaluation of the proposed FDA pilot-dose response methodology for topical corticosteroid bioeqivalence testing [authors' reply in Letters to the Editor] https://vital.seals.ac.za/vital/access/manager/Repository/vital:6423 Thu 13 May 2021 07:43:38 SAST ]]> Reply to correspondence: P.M. Gaylarde (1986) The human skin blanching assay—use and abuse https://vital.seals.ac.za/vital/access/manager/Repository/vital:6376 Thu 13 May 2021 07:39:12 SAST ]]> In Vitro Release Testing (IVRT) of Topical Hydrocortisone Acetate Creams: a novel approach using positive and negative controls https://vital.seals.ac.za/vital/access/manager/Repository/vital:38888 Thu 13 May 2021 07:29:26 SAST ]]> The human skin blanching assay for in vivo topical corticosteroid assessment. II. Subject- and observer-dependent variation in blanching responses https://vital.seals.ac.za/vital/access/manager/Repository/vital:6382 Thu 13 May 2021 07:14:28 SAST ]]> Relative potencies of topical corticosteroid formulations https://vital.seals.ac.za/vital/access/manager/Repository/vital:6375 Thu 13 May 2021 06:48:19 SAST ]]> Pharmacokinetics of phenylpropanolamine in humans after a single dose study https://vital.seals.ac.za/vital/access/manager/Repository/vital:6363 Thu 13 May 2021 02:03:39 SAST ]]> The simultaneous determination of trimethoprim, sulphamethoxazole and N4-acetylsulphamethoxazole in biological fluids by high pressure liquid chromatography https://vital.seals.ac.za/vital/access/manager/Repository/vital:6364 Thu 13 May 2021 00:56:56 SAST ]]> Comparative bioavailability of some locally manufactured betamethasone valerate containing preparations https://vital.seals.ac.za/vital/access/manager/Repository/vital:6399 Thu 13 May 2021 00:28:45 SAST ]]> Sensitive high-performance liquid chromatographic determination of cyclizine and its demethylated metabolite, norcyclizine, in biological fluids using coulometric detection https://vital.seals.ac.za/vital/access/manager/Repository/vital:6452 Thu 13 May 2021 00:14:01 SAST ]]> A stability-indicating HPLC assay with on-line clean-up for betamethasone 17-valerate in topical dosage forms https://vital.seals.ac.za/vital/access/manager/Repository/vital:6421 Thu 13 May 2021 00:03:40 SAST ]]> Pharmacokinetics of cyclizine following intravenous administration to human volunteers https://vital.seals.ac.za/vital/access/manager/Repository/vital:44214 Fri 20 Aug 2021 13:20:03 SAST ]]>