https://vital.seals.ac.za/vital/access/manager/Index en-us 5 An investigation into the visual literacy skills of Black primary-school children from an informal settlement in Cape Town, with particular reference to visual imagery in educational textbooks https://vital.seals.ac.za/vital/access/manager/Repository/vital:2403 Wed 12 Oct 2022 12:47:59 SAST ]]> Epithermal precious metal deposits physicochemical constraints, classification characteristics and exploration guidelines https://vital.seals.ac.za/vital/access/manager/Repository/vital:4941 Wed 12 May 2021 22:54:13 SAST ]]> An overview of the early-proterozoic, auriferous Black Reef placer in the Transvaal Basin https://vital.seals.ac.za/vital/access/manager/Repository/vital:4984 Wed 12 May 2021 22:36:54 SAST ]]> Isolation and identification of Beta-Lactam Producing Microorganisms using PCR based methodologies https://vital.seals.ac.za/vital/access/manager/Repository/vital:4155 Wed 12 May 2021 20:51:24 SAST ]]> Struggle in discourse the International's discourse against racism in the labour-movement in South Africa (1915-1919) https://vital.seals.ac.za/vital/access/manager/Repository/vital:3419 Wed 12 May 2021 20:37:15 SAST ]]> Student teachers' conceptualisations of 'significant' animals https://vital.seals.ac.za/vital/access/manager/Repository/vital:1775 Wed 12 May 2021 20:32:05 SAST ]]> Structural and stereochemical investigations of terrestrial and marine pyrone metabolites https://vital.seals.ac.za/vital/access/manager/Repository/vital:4348 Wed 12 May 2021 20:29:01 SAST ]]> A case-study of principal succession : the experience of a high school principal and staff https://vital.seals.ac.za/vital/access/manager/Repository/vital:1440 Wed 12 May 2021 20:20:14 SAST ]]> An examination of the factors underlying decision-making about selection and presentation of photographs of political conflict in South African newspapers https://vital.seals.ac.za/vital/access/manager/Repository/vital:3478 Wed 12 May 2021 20:12:36 SAST ]]> A collated digital, geological map database for the central Namaqua Province using geographical information system technology https://vital.seals.ac.za/vital/access/manager/Repository/vital:4936 Wed 12 May 2021 19:51:30 SAST ]]> A predictive biogeography of selected alien plant invaders in South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:4846 Wed 12 May 2021 19:46:07 SAST ]]> An investigation of nondeterminism in functional programming languages https://vital.seals.ac.za/vital/access/manager/Repository/vital:4658 Wed 12 May 2021 19:32:22 SAST ]]> The spatial planning of racial residential segregation in King William's Town : 1826-1991 https://vital.seals.ac.za/vital/access/manager/Repository/vital:4855 Wed 12 May 2021 19:17:37 SAST ]]> The role of interpreters in medical communication in the Eastern Cape https://vital.seals.ac.za/vital/access/manager/Repository/vital:2349 Wed 12 May 2021 18:50:25 SAST ]]> Guidelines for assessing single borehole yields in secondary aquifers https://vital.seals.ac.za/vital/access/manager/Repository/vital:6026 Wed 12 May 2021 18:46:19 SAST ]]> The use of remote sensing and Geographic Information System (GIS) techniques, to interpret savanna ecosystem patterns in the Sabi Sand Game Reserve, Mpumalanga province https://vital.seals.ac.za/vital/access/manager/Repository/vital:4857 Wed 12 May 2021 17:49:51 SAST ]]> Assessment of amoxycillin suppositories https://vital.seals.ac.za/vital/access/manager/Repository/vital:3802 Wed 12 May 2021 17:47:40 SAST ]]> The development potential of Kwazulu-Natal aquifers for rural water supply https://vital.seals.ac.za/vital/access/manager/Repository/vital:4938 Wed 12 May 2021 17:39:17 SAST ]]> A critical investigation of the Primary Schools Nutrition Programme (PSNP) in the Eastern Cape https://vital.seals.ac.za/vital/access/manager/Repository/vital:2783 Wed 12 May 2021 17:23:58 SAST ]]> Student-teachers' perspectives of the role of environmental education in geography education https://vital.seals.ac.za/vital/access/manager/Repository/vital:1776 Wed 12 May 2021 17:21:57 SAST ]]> Newspapers in education programmes and South African youth: a survey of the relationship between South African school-goers and newspapers in Esikhawini, Kwazulu-Natal https://vital.seals.ac.za/vital/access/manager/Repository/vital:3465 Wed 12 May 2021 17:14:16 SAST ]]> Responding to literature: empowering girls to speak with their own voices in a multicultural context https://vital.seals.ac.za/vital/access/manager/Repository/vital:1742 Wed 12 May 2021 16:37:34 SAST ]]> A comparative photostability study of four propyl piperzine-substituted phenothiazines https://vital.seals.ac.za/vital/access/manager/Repository/vital:3756 trifluoperazine> perphenazine > rochlorperazine. In order to assess their photostability an HPLC method was developed and validated for linearity, accuracy and precision, selectivity, limit of detection and quantitation and ruggedness. Preliminary solution photostudies under controlled light conditions (UV, sunlight, fluorescent light) indicated that the rate of degradation followed first-order kinetics with perphenazine the most susceptible to.photodegradation under all light conditions studied. In vitro and in vivo metabolism yielding the 5-sulphoxide and its reported presence on decomposition of the phenothiazines25 led to the development of a synthetic procedure suitable for the sutphoxides of all four derivatives based on the method proposed by Owens et al. in order to provide standards for comparison in the photostudies⁷. Since ICH regulations require that impurities> 0.1 % are examined and identified⁷⁴ and semi-preparative isolation of photoproducts proved unsuccessful, LC-MS having been well documented for structural.elucidation⁷⁵ ⁷⁵ ⁷⁶ ⁷⁷ was used to characterize solution (UV, sunlight, fluorescent light) and preliminary solid (UV) photostudies. The chloroderivatives underwent dechlorination and sulphoxidation with subsequent photosubstitution in the case of prochlorperazine to yield the 2-hydroxy derivative and sulphoxidation of the dechloro-derivative of perphenazine. The sulphoxides of both trifluoperazine and fluphenazine were formed with further oxidation to the respective sulphones occurring. Preliminary solid state (UV) photostudies showed fluphenazine to be the least stable with 30.71 % degradation as opposed to 7.57% for prochlorperazine, 4.28% for perphenazine and 7.10% for trifluoperazine witn sulphoxidation observed to be. the major degradation pathway. Since in vitro metabolism of perazine derivatives is reported to occur via N-oxidation, N-demethylation, sulphoxidation and aromatic hydroxylation¹⁸ it does appear that there is some correlation between metabolic and photoproducts. However the fact that solution (UV) photostudies indicates trifluoperazine to be the most and perphenazine the least stable does not concur with the proposed order of pharmacological activity.]]> Wed 12 May 2021 16:36:16 SAST ]]> The African National Congress' foreign policy in transition: change or continuity, 1989-1994 https://vital.seals.ac.za/vital/access/manager/Repository/vital:2797 Wed 12 May 2021 16:29:58 SAST ]]> Cytogenetic studies of Pseudobarbus and selected Barbus (Pisces: Cyprinidae) of southern Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:5252 Wed 12 May 2021 15:44:24 SAST ]]> Die ontwikkeling van 'n plattelandse tak van die ACVV 1900-1996 https://vital.seals.ac.za/vital/access/manager/Repository/vital:694 Wed 10 Aug 2022 06:00:16 SAST ]]> Towards an understanding of Amayeza esiXhosa stores (African chemists): how they operate, and the services they offer in the Eastern Cape https://vital.seals.ac.za/vital/access/manager/Repository/vital:2096 Wed 07 Jul 2021 13:13:52 SAST ]]> Juvenile diversion: keeping children out of prison https://vital.seals.ac.za/vital/access/manager/Repository/vital:3682 Thu 13 May 2021 15:06:08 SAST ]]> Dennett's compatibilism considered https://vital.seals.ac.za/vital/access/manager/Repository/vital:2718 Thu 13 May 2021 12:02:24 SAST ]]> A quantitative survey of knowledge, attitudes and behaviour, related to AIDS/HIV, among Zulu speaking standard eight high school students https://vital.seals.ac.za/vital/access/manager/Repository/vital:2987 Thu 13 May 2021 11:56:28 SAST ]]> Knowledge of safe sex practices and HIV transmission, propensity for risk taking, and alcohol/drug use in the aetiology of unprotected sex https://vital.seals.ac.za/vital/access/manager/Repository/vital:3146 Thu 13 May 2021 08:45:37 SAST ]]> Periglacial features in the vicinity of Tiffindell Ski Resort, North East Cape Drakensberg, South Africa, and their implications for the development of the resort https://vital.seals.ac.za/vital/access/manager/Repository/vital:4844 Thu 13 May 2021 08:12:15 SAST ]]> A theology of spiritual direction for the Presbyterian Church of Southern Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:1301 Thu 13 May 2021 08:07:07 SAST ]]> A new empirical model for the peak ionospheric electron density using neural networks https://vital.seals.ac.za/vital/access/manager/Repository/vital:5478 Thu 13 May 2021 07:39:27 SAST ]]> A reconstruction of the history of land degradation in relation to land use change and land tenure in Peddie district, former Ciskei https://vital.seals.ac.za/vital/access/manager/Repository/vital:4847 Thu 13 May 2021 07:25:44 SAST ]]> Theories of international cooperation and the GATT/WTO regime: beyond the dichotomy of rational and cognitive approaches https://vital.seals.ac.za/vital/access/manager/Repository/vital:2817 Thu 13 May 2021 07:08:20 SAST ]]> An investigation into the enlightenment and aspects of Spanish life which may have influenced Los Caprichos (1797-1799) of Francisco de Goya (1746-1828) https://vital.seals.ac.za/vital/access/manager/Repository/vital:2421 Thu 13 May 2021 07:02:24 SAST ]]> Fungal and substrate-associated factors affecting lignocellulolytic mushroom cultivation on wood sources available in South African [i.e. Africa] https://vital.seals.ac.za/vital/access/manager/Repository/vital:4020 Thu 13 May 2021 06:21:51 SAST ]]> Punishment in schools: perspectives of parents, teachers and pupils https://vital.seals.ac.za/vital/access/manager/Repository/vital:3051 Thu 13 May 2021 05:38:53 SAST ]]> Macroinvertebrate community and species responses to chlorinated sewage effluent in the Umsunduze and Umbilo rivers, Kwa Zulu-Natal, South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:5727 Thu 13 May 2021 05:33:27 SAST ]]> The role of drinking fathers in later contradictions and choices in the lives of married women https://vital.seals.ac.za/vital/access/manager/Repository/vital:3018 Thu 13 May 2021 05:29:36 SAST ]]> Environmental perceptions and knowledge among political leaders in the Eastern Cape Province and some implications for environmental policy https://vital.seals.ac.za/vital/access/manager/Repository/vital:1517 Thu 13 May 2021 05:27:26 SAST ]]> Chemical studies of necic acid analogues https://vital.seals.ac.za/vital/access/manager/Repository/vital:4425 Thu 13 May 2021 05:19:00 SAST ]]> Negotiating a comprehensive long-term relationship between South Africa and the European Union: from free trade to trade and development https://vital.seals.ac.za/vital/access/manager/Repository/vital:2768 Thu 13 May 2021 05:15:59 SAST ]]> Corporate taxes and the taxation of dividends https://vital.seals.ac.za/vital/access/manager/Repository/vital:890 Thu 13 May 2021 05:12:23 SAST ]]> Investigations into the dietary protein requirements of juvenile spotted grunter, Pomadasys commersonnii (Haemulidae : Pisces) https://vital.seals.ac.za/vital/access/manager/Repository/vital:5292 Thu 13 May 2021 04:43:08 SAST ]]> Generalisations of filters and uniform spaces https://vital.seals.ac.za/vital/access/manager/Repository/vital:5409 Thu 13 May 2021 04:37:02 SAST ]]> Investigations into the larval rearing of two South African sparid species https://vital.seals.ac.za/vital/access/manager/Repository/vital:5293 Thu 13 May 2021 03:51:38 SAST ]]> The application of a landscape diversity index using remote sensing and geographical information systems to identify degradation patterns in the Great Fish River Valley, Eastern Cape Province, South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:4814 Thu 13 May 2021 03:40:42 SAST ]]> Contemporary experiences of the Buddhist mediation practice: a case-study approach https://vital.seals.ac.za/vital/access/manager/Repository/vital:3156 Thu 13 May 2021 03:38:59 SAST ]]> Teaching disciplinary discourse and implementing language-across-the-curriculum at tertiary level problems and prospects https://vital.seals.ac.za/vital/access/manager/Repository/vital:2340 Thu 13 May 2021 03:36:27 SAST ]]> Extracellular digestion in two intertidal mussels and the role played by their gut bacteria https://vital.seals.ac.za/vital/access/manager/Repository/vital:5692 Thu 13 May 2021 03:16:35 SAST ]]> Idolatry and the artist's role with special reference to the work and thought of Andy Warhol https://vital.seals.ac.za/vital/access/manager/Repository/vital:2425 Thu 13 May 2021 03:13:17 SAST ]]> Participatory programme development at an environmental education centre through action research involving secondary school teachers https://vital.seals.ac.za/vital/access/manager/Repository/vital:1690 Thu 13 May 2021 02:48:39 SAST ]]> A case study of English/Xhosa code switching as a communicative and learning resource in an English medium classroom https://vital.seals.ac.za/vital/access/manager/Repository/vital:1436 Thu 13 May 2021 02:32:21 SAST ]]> Effects of sustained elevated CO₂ concentration on two cultivars of barley (Hordeum vulgare L.) https://vital.seals.ac.za/vital/access/manager/Repository/vital:4226 Thu 13 May 2021 01:32:39 SAST ]]> Eco-ethology of shell-dwelling cichlids in Lake Tanganyika https://vital.seals.ac.za/vital/access/manager/Repository/vital:5265 Thu 13 May 2021 01:13:19 SAST ]]> The use of the female voice in three novels by J.M. Coetzee https://vital.seals.ac.za/vital/access/manager/Repository/vital:2224 Thu 13 May 2021 01:12:42 SAST ]]> Application of capillary electrophoresis for the assay of erythromycin and its related substance https://vital.seals.ac.za/vital/access/manager/Repository/vital:3765 Thu 13 May 2021 00:59:57 SAST ]]> An evaluation of small scale open cast mining of UG2 in the Bushveld complex https://vital.seals.ac.za/vital/access/manager/Repository/vital:4943 Thu 13 May 2021 00:25:05 SAST ]]> An investigation into the effects of inorganic toxins and tryptophan metabolites on the forebrain cholinergic system and the pineal gland of the rat https://vital.seals.ac.za/vital/access/manager/Repository/vital:4018 Thu 13 May 2021 00:24:29 SAST ]]> The biology of two important by-catch skate species on the Agulhas Bank, South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:5240 Thu 13 May 2021 00:22:42 SAST ]]> The effect of work-hardening on the physical work capacity of manual labourers within South African industry https://vital.seals.ac.za/vital/access/manager/Repository/vital:5165 Thu 13 May 2021 00:21:45 SAST ]]> An investigation into patterns of interaction in small teaching groups at Rhodes University, with particular emphasis on the effect of gender, mother-tongue and educational background https://vital.seals.ac.za/vital/access/manager/Repository/vital:2350 Thu 13 May 2021 00:18:41 SAST ]]> Exploitation of the bait organism Upogebia africana (Crustacea: Anomura) in the Knysna estuary https://vital.seals.ac.za/vital/access/manager/Repository/vital:5691 Thu 13 May 2021 00:02:46 SAST ]]> Towards a developed regional order: which way forward southern Africa? https://vital.seals.ac.za/vital/access/manager/Repository/vital:2760 Thu 01 Feb 2024 09:52:57 SAST ]]>