https://vital.seals.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://vital.seals.ac.za/vital/access/manager/Repository/vital:45563 Tue 07 May 2024 15:51:12 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45518 Tue 07 May 2024 15:49:36 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45419 5000 mg/kg. The n-hexane fraction of the extract contains steroids, terpenes and fatty acids and yielded non-cytotoxic terpenoidal column fraction with anti-trypanosomal IC50 of 3.0 μg/mL. The ethylacetate fraction at 100 mg/kg dose significantly (p less than 0.05) provoked 37.8, 62.5 and 69.7% inhibition of oedema induced by egg-albumin at the second, fourth and sixth hours respectively. Conclusion: The study demonstrated that the anti-inflammatory and anti-trypanosomal activities of A. vogelii are probably due to non-cytotoxic terpenoids and validated the traditional use of A. vogelii in the treatment of inflammation and sleeping sickness.]]> Tue 07 May 2024 15:43:34 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45417 Tue 07 May 2024 15:43:11 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45416 Tue 07 May 2024 15:42:16 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45413 Tue 07 May 2024 15:41:33 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45162 Tue 07 May 2024 15:33:59 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45160 Tue 07 May 2024 15:33:09 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45159 Tue 07 May 2024 15:32:48 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45324 Tue 07 May 2024 12:37:29 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45519 Tue 07 May 2024 12:28:00 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45516 n-hexane extract (IC50=25.18 μg/mL). It also showed mild cytotoxicity (IC50>100 μg/mL; selectivity index >4) compared to the reference drug emetine (IC50=0.013 μg/mL). The known sterol, ergostan-5,7,22-trien-3-ol, was isolated and characterized from the extract. Conclusion: This study reporting for the first time the antiplasmodial activity of P. ostreatus revealed its nutraceutical potential in the management of malaria.]]> Tue 07 May 2024 12:27:04 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45163 Tue 07 May 2024 12:24:14 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:45161 Fri 12 Nov 2021 22:15:03 SAST ]]>