https://vital.seals.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 The introduction of cyberhunts as a teaching and learning strategy to guide teachers towards the integration of computer technology in schools https://vital.seals.ac.za/vital/access/manager/Repository/vital:9555 Wed 12 May 2021 23:46:43 SAST ]]> An analysis of emerging forms of social organisation and agency in the aftermath of 'fast track' land reform in Zimbabwe https://vital.seals.ac.za/vital/access/manager/Repository/vital:3293 Wed 12 May 2021 23:13:23 SAST ]]> Evaluation of antidiarrhoeal and toxicological properties of Hermannia Incana cav.: a South African medicinal plant https://vital.seals.ac.za/vital/access/manager/Repository/vital:11304 Wed 12 May 2021 23:12:42 SAST ]]> Investigations of the bioavailability/bioequivalence of topical corticosteroid formulations containing clobetasol propionate using the human skin blanching assay, tape stripping and microdialysis https://vital.seals.ac.za/vital/access/manager/Repository/vital:3743 Wed 12 May 2021 23:03:21 SAST ]]> Messages from the deep : water divinities, dreams and diviners in Southern Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:2112 Wed 12 May 2021 22:58:47 SAST ]]> Isolation and evolution of novel nucleoside phosphorylases https://vital.seals.ac.za/vital/access/manager/Repository/vital:3972 Wed 12 May 2021 22:58:38 SAST ]]> Implementation of novel flow cytometric methods to assess the in vitro antidiabetic mechanism of a Sutherlandia Frutescens extract https://vital.seals.ac.za/vital/access/manager/Repository/vital:10304 Wed 12 May 2021 22:57:18 SAST ]]> A critical analysis of discourses constructing portfolio assessment practices in three Eastern Cape schools https://vital.seals.ac.za/vital/access/manager/Repository/vital:1468 Wed 12 May 2021 22:56:59 SAST ]]> An investigation into the feasibility of incorporating didanosine into innovative solid lipid nanocarriers https://vital.seals.ac.za/vital/access/manager/Repository/vital:3800 Wed 12 May 2021 22:52:54 SAST ]]> Metabolic energy relations in the Eastern Cape Angulate Tortoise (Chersina Anguluta) https://vital.seals.ac.za/vital/access/manager/Repository/vital:10690 Wed 12 May 2021 22:50:59 SAST ]]> The adoption of quality assurance in e-Health acquisition for rural hospitals in the Eastern Cape Province https://vital.seals.ac.za/vital/access/manager/Repository/vital:9731 Wed 12 May 2021 22:23:10 SAST ]]> Historical biogeography of the tribe Platypleurini Schmidt, 1918 (Hemiptera: Cicadidae) with a focus on Southern Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:5708 Wed 12 May 2021 20:37:54 SAST ]]> Studies on mixed-species colonies of honeybees, Apis cerana and Apis mellifera https://vital.seals.ac.za/vital/access/manager/Repository/vital:5779 Wed 12 May 2021 20:33:10 SAST ]]> Spatially resolved opto-electric measurements of photovoltaic materials and devices https://vital.seals.ac.za/vital/access/manager/Repository/vital:10520 Wed 12 May 2021 20:28:36 SAST ]]> A case study : exploring a DVD driven approach for teaching and learning mathematics, at secondary school level, with a framework of blended learning https://vital.seals.ac.za/vital/access/manager/Repository/vital:10504 Wed 12 May 2021 20:21:45 SAST ]]> A social realist analysis of collaborative curriculum development processes in an academic department at a South African university https://vital.seals.ac.za/vital/access/manager/Repository/vital:3339 Wed 12 May 2021 19:52:59 SAST ]]> Improving Productivity of Maize-based Smallholder Irrigated Cropping Systems: A Case Study of Zanyokwe Irrigation Scheme, Eastern Cape, South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:36450 Wed 12 May 2021 19:32:07 SAST ]]> Induced plant responses of different Lantana camara L. (Verbenaceae) varieties to herbivory by Falconia intermedia (distant) (Hemiptera: Miridae) https://vital.seals.ac.za/vital/access/manager/Repository/vital:5911 Wed 12 May 2021 19:25:52 SAST ]]> Challenges in topside ionospheric modelling over South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:5453 Wed 12 May 2021 18:37:56 SAST ]]> Studies on the nutritional value of seven accessions of cocoyam growing in South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:11305 Wed 12 May 2021 18:34:12 SAST ]]> Neurocognitive and symptom profiles of concussed and nonconcussed provincial rugby players over one season https://vital.seals.ac.za/vital/access/manager/Repository/vital:2950 Wed 12 May 2021 18:32:37 SAST ]]> Beta-N-methylamino-L-alanine in South African fresh water cyanobacteria : incidence, prevalence, ecotoxicological considerations and human exposure risk https://vital.seals.ac.za/vital/access/manager/Repository/vital:10306 Wed 12 May 2021 18:28:30 SAST ]]> Rethinking South Africa's small-scale fisheries management paradigm and governance approach : evidence from the Eastern Cape https://vital.seals.ac.za/vital/access/manager/Repository/vital:5202 Wed 12 May 2021 17:04:36 SAST ]]> The integration of natural resource management into the curriculum of rural under-resourced schools : a Bernsteinian analysis https://vital.seals.ac.za/vital/access/manager/Repository/vital:4762 Wed 12 May 2021 16:51:32 SAST ]]> Formulation and evaluation of captopril loaded polymethacrylate and hydroxypropyl methycellulose microcapsules https://vital.seals.ac.za/vital/access/manager/Repository/vital:3860 Wed 12 May 2021 16:38:12 SAST ]]> Isomorphism, institutional entrepreneurship and total quality management (TQM) : a case study in the implementation of quality management standards and excellence models in South African developmental local government https://vital.seals.ac.za/vital/access/manager/Repository/vital:1193 Wed 12 May 2021 16:09:10 SAST ]]> Photophysiochemical studies of d¹⁰ metallophthalocyanines and their interaction with nanoparticles https://vital.seals.ac.za/vital/access/manager/Repository/vital:4335 Wed 12 May 2021 16:06:41 SAST ]]> Sample preparation for pesticide analysis in water and sediments a case study of the Okavango Delta, Botswana https://vital.seals.ac.za/vital/access/manager/Repository/vital:4344 Wed 12 May 2021 15:52:10 SAST ]]> The characterisation of trypanosomal type 1 DnaJ-like proteins https://vital.seals.ac.za/vital/access/manager/Repository/vital:4126 Wed 12 May 2021 15:44:21 SAST ]]> The phytogeography of the Sneeuberg, Nuweveldberge and Roggeveldberge (Great Escarpment): assessing migration routes and endemism https://vital.seals.ac.za/vital/access/manager/Repository/vital:4187 Thu 13 May 2021 13:32:45 SAST ]]> The use of response surface methodology and artificial neural networks for the establishment of a design space for a sustained release salbutamol sulphate formulation https://vital.seals.ac.za/vital/access/manager/Repository/vital:3845 Thu 13 May 2021 08:22:13 SAST ]]> Indigenous technology and culture in the technology curriculum : starting the conversation : a case study https://vital.seals.ac.za/vital/access/manager/Repository/vital:1573 Thu 13 May 2021 07:40:59 SAST ]]> Audit of community pharmacy activities https://vital.seals.ac.za/vital/access/manager/Repository/vital:10130 Thu 13 May 2021 07:12:51 SAST ]]> A combination of platinum anticancer drugs and mangiferin causes increased efficacy in cancer cell lines https://vital.seals.ac.za/vital/access/manager/Repository/vital:10338 Thu 13 May 2021 07:01:58 SAST ]]> Prevalence of Listeria pathogens in effluents of some wastewater treatment facilities in the Eastern Cape Province of South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:30747 Thu 13 May 2021 06:17:36 SAST ]]> An investigation of IgE regulation by recombinant soluble IgE receptors and co-receptors in human cell culture models https://vital.seals.ac.za/vital/access/manager/Repository/vital:10321 sCD23>derCD23) for IgE, upon increasing length of the proximal CD23 “stalk” domain. These findings highlight the differences in both the structural basis and affinity of the three physiological fragments of human CD23 for the ligands CD21 and IgE and underscore the complexity of CD23-mediated regulatory networks. It was found that B-cells only make up ~5% of the PBMC population, and that these cells were able to be activated, via STAT-6 phosphorylation, to enter class switch recombination (CSR) by the addition of switch factors (IL-4 and anti-CD40). Titration experiments dictated that 25 ng/mL of CD23 was the most efficient concentration to up-regulate IgE synthesis in PBMCs; furthermore, soluble CD23 proteins were incubated with PBMCs in the presence and absence of CD21 SCR 1-2 to investigate the effect that these recombinant proteins have on IgE synthesis. Results showed that the influence of recombinant proteins (both CD23 and CD21) on IgE synthesis was slight. It was shown that while derCD23 had no significant effect, monomeric sCD23 down-regulated, and the mixture of monomeric and oligomeric exCD23 up-regulated IgE synthesis. On addition of CD21 SCR 1-2 to the cells switched and treated with soluble CD23, it was found that in both cases for sCD23 and exCD23, IgE synthesis was increased, while for derCD23, there was no noticeable difference in IgE synthesis. This confirmed previous data showing the lack of binding between derCD23 and CD21 SCR 1-2. The exact binding site for CD21 on the CD23 molecule is unknown, and incompletely represented in the NMR and crystal structures. It is thought that CD21 binds to the C-terminal tail section, not present in derCD23. It is therefore likely that only a negative-feedback mechanism operates with derCD23 to regulate IgE synthesis. Further investigation of the binding of CD23 fragments to SCR 5-8 of CD21 and the effect of this on IgE synthesis may lead to a potential therapeutic role for derCD23 in the treatment of allergic disease. Data accumulated in this study suggests that investigating the modulation of oligomeric state and thus the activity of soluble CD23 fragments may be important in the construction of new regulators of IgE synthesis.]]> Thu 13 May 2021 05:44:14 SAST ]]> Metallophthalocyanines as electrocatalysts and superoxide dismutase mimics https://vital.seals.ac.za/vital/access/manager/Repository/vital:4325 Thu 13 May 2021 04:49:41 SAST ]]> Molecular and cellular analysis of the interaction between soluble CD23 and CD11/CD18 integrins https://vital.seals.ac.za/vital/access/manager/Repository/vital:10303 Thu 13 May 2021 04:27:58 SAST ]]> Ecology and degree of specialization of South African milkweeds with diverse pollination systems https://vital.seals.ac.za/vital/access/manager/Repository/vital:4189 Thu 13 May 2021 04:04:16 SAST ]]> Leonotis leonurus: the anticoagulant and antidiabetic activity of Leonotis leonurus https://vital.seals.ac.za/vital/access/manager/Repository/vital:10323 Thu 13 May 2021 03:53:26 SAST ]]> The in vitro biological activities of three Hypoxis species and their active compounds https://vital.seals.ac.za/vital/access/manager/Repository/vital:10322 Thu 13 May 2021 03:37:18 SAST ]]> Fostering information security culture through intergrating theory and technology https://vital.seals.ac.za/vital/access/manager/Repository/vital:9754 Thu 13 May 2021 02:53:50 SAST ]]> Lag length selection for vector error correction models https://vital.seals.ac.za/vital/access/manager/Repository/vital:5568 Thu 13 May 2021 01:47:49 SAST ]]> The development and implementation of an evaluation for rural ICT projects in developing countries: an exploration of the Siyakhulu Living Lab, South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:1138 Thu 13 May 2021 01:42:57 SAST ]]> The biotechnology of hard coal utilization as a bioprocess substrate https://vital.seals.ac.za/vital/access/manager/Repository/vital:3934 Thu 13 May 2021 01:28:43 SAST ]]> Towards social impact assessment of copper-nickel mining in Botswana https://vital.seals.ac.za/vital/access/manager/Repository/vital:10644 Thu 13 May 2021 01:26:10 SAST ]]> Exploring and expanding learning processes in sustainable agriculture workplace contexts https://vital.seals.ac.za/vital/access/manager/Repository/vital:1539 Thu 13 May 2021 01:09:49 SAST ]]> Psigobiografiese persoonlikheidsbeskrywing van Generaal Christiaan de Wet https://vital.seals.ac.za/vital/access/manager/Repository/vital:2990 Thu 13 May 2021 00:52:24 SAST ]]> Synthesis, characterization and reactions of novel ferrocenylimidazoles as donor ligands https://vital.seals.ac.za/vital/access/manager/Repository/vital:10390 Thu 13 May 2021 00:47:05 SAST ]]> Aerial optical fibres in telecommunication systems : SOP and PMD monitoring, and tolerance of modulation formats https://vital.seals.ac.za/vital/access/manager/Repository/vital:10542 Thu 13 May 2021 00:41:15 SAST ]]> Photoluminescence study of ZnO doped with nitrogen and arsenic https://vital.seals.ac.za/vital/access/manager/Repository/vital:10518 Thu 13 May 2021 00:39:09 SAST ]]> A contribution to TEC modelling over Southern Africa using GPS data https://vital.seals.ac.za/vital/access/manager/Repository/vital:5456 Thu 13 May 2021 00:26:54 SAST ]]> An empirical phenomenological investigation of procrastinating behaviour https://vital.seals.ac.za/vital/access/manager/Repository/vital:2929 Thu 13 May 2021 00:13:14 SAST ]]> Consolidating democracy through integrating the chieftainship institution with elected councils in Lesotho: a case study of four community councils in Maseru https://vital.seals.ac.za/vital/access/manager/Repository/vital:2786 Thu 01 Feb 2024 09:54:41 SAST ]]> Multilingualism and ICT education at Rhodes University: an exploratory study https://vital.seals.ac.za/vital/access/manager/Repository/vital:1673 Mon 17 Jan 2022 13:25:23 SAST ]]> Intertidal patterns and processes : tracking the effects of coastline topography and settlement choice across life stages of the mussels perna perna and mytilus galloprovincialis https://vital.seals.ac.za/vital/access/manager/Repository/vital:5721 Fri 14 Jan 2022 10:57:18 SAST ]]>