https://vital.seals.ac.za/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://vital.seals.ac.za/vital/access/manager/Repository/vital:10686 1000 per annum), inshore trawling (ca. 41 per annum), shark nets (protective gill nets) (21.6 ± 6.7 per annum) and the pelagic longline fishery (5.0 ± 4.4 per annum). In contrast, leatherbacks with a pelagic lifestyle, were mostly exposed to pelagic longline fisheries (7.8 ± 7.8 per annum). A spatial analysis of fishing activities indicated that leatherback home ranges overlapped 41percent with pelagic longline fishing activity in the SA EEZ, whereas the overlap between pelagic longliners and loggerhead home ranges was 29 percent. The quantified sources of mortality provide some explanation for the trend in the loggerhead nesting population but not the trend in the leatherback nesting population. Hatchling survivorship to adulthood was estimated to determine the viability of the two nesting populations as well as to determine whether offshore mortality was responsible for the difference in recovery of the two populations. Loggerhead hatchling survivorship to adulthood was estimated at between 2 and 10 per 1000 hatchlings, the minimum requirement for an increasing population. The adopted sophisticated model shows that leatherbacks have a survival rate of 5 to 10 per 1 000 hatchlings. However, this suggests that the population is increasing, but the leatherback population is stable. Perhaps the age to maturity of SA leatherbacks is greater than 12 years, or fisheries-related mortality affects younger age classes than initially thought. It is therefore recommended that the turtle monitoring area is extended to include other potential nesting grounds. In addition, observer or monitoring programs for commercial as well as artisanal fisheries needs to be extended throughout the SWIO to quantify sea turtle mortality. Ultimately a comprehensive multi-regional approach is required for the conservation of these highly migratory species.]]> Wed 23 Jun 2021 09:43:42 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:29968 Wed 23 Jun 2021 09:43:39 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:28265 Wed 13 Mar 2024 14:17:24 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:41619 80 μg∙L-1, ≥ 2781 H. akashiwo cells∙mL-1). Dissolved oxygen differed significantly by bloom state, with the highest dissolved oxygen concentrations. Larval fish density, diversity and community structure variability were lower during hypereutrophic blooms compared to standard blooms and bloom absence, albeit statistically insignificant. Estuarine resident larval density was negatively correlated with dissolved oxygen concentration (P < 0.001). Dominant prey copepod of G. aestuaria larvae, P. hessei, was less abundant and variable during hypereutrophic blooms (mean: 664, range: 4-4301 individuals per m3) compared to standard blooms (mean: 950, range: 2-5237 individuals per m3) and bloom absence (mean: 1182, range: 23-7259 individuals per m3). Although HABs did not appear to drive a mismatch between prey and G. aestuaria larvae, early juvenile larvae made only a small contribution to the assemblage (0.2-1.8%). In terms of predator effects, yolk sac larvae were negatively related to R. terranatalis (P < 0.05). A significant positive relationship was found between prey, P. hessei and G. aestuaria preflexion (P < 0.001), flexion (P < 0.001) and postflexion (P < 0.05) larvae. In a world first, the effects of HABs were investigated on a larval fish species, Gilchristella aestuaria, using biochemical body condition analyses. During severe bloom conditions, G. aestuaria larvae were smaller and the assemblage consisted of mainly early developmental stages (stats). Body condition (RNA per dry weight) was poorest in the presence of hypereutrophic blooms (P < 0.001). A bell-curved relationship between RNA/DW and dissolved oxygen concentration was also produced in a 3-day time-lagged GAM (P < 0.001). In conclusion, hypereutrophic bloom conditions appeared to trigger adult G. aestuaria spawning in the upper mesohaline zone of the estuary in response to heightened primary productivity which occurs during the early bloom stage. However, reductions in copepod abundance (P. hessei) and unfavourable oxygen concentrations interfered with grow-out of G. aestuaria larvae. This research showed that HABs can alter nursery properties to the detriment of G. aestuaria larvae can have serious knock-on effects up the food chain. The loss in abundance of adult, juvenile and larval G. aestuaria, a key forage fish in South African estuaries, has major implications for estuarine food webs, especially in reduced prey availability to juvenile fishes and birds. There is still much to learn about the effects of HABs on the physiological and behavioural aspects on plankton communities worldwide.]]> Wed 13 Mar 2024 14:10:51 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:41611 Wed 13 Mar 2024 14:10:26 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:28757 Wed 13 Mar 2024 14:10:22 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:32483 Wed 13 Mar 2024 11:50:54 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:35643 Wed 13 Mar 2024 11:50:28 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:20443 Wed 13 Mar 2024 11:43:41 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:35510 Wed 13 Mar 2024 11:43:34 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:27307 Wed 13 Mar 2024 11:29:58 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:31348 Wed 13 Mar 2024 11:29:23 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:29807 Wed 13 Mar 2024 10:05:29 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10593 Wed 13 Mar 2024 09:41:38 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:41606 Wed 13 Mar 2024 09:37:38 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:27363 Wed 13 Mar 2024 09:16:24 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:30794 Wed 08 Feb 2023 09:51:50 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:30778 Wed 08 Feb 2023 09:41:49 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:36614 5m). This study aimed to address this information gap. Dive surveys were conducted along 10 m long transects (~3 reps) at three depth zones (<1m; 1-2m; > 2m) for four sites along the span of the ranching concession area. Similar assessments were done at a seeded site at the Noordhoek Ski Boat Club and an unseeded site at the Willows area, in order to reveal whether seeding had any impact on the benthic community. Images from a GoPro mounted in the centre of a framer unit (0.5 m2) were taken every 0.5 m along the transect. Macroalgal and macrofaunal cover was determined from these images, and the benthic community characterised from these data. Seaweed samples were taken for species identification. In the four baseline sites, sampling was done at three depth zones to note any changes with a depth gradient, both in terms of substrate type, as well as community composition. There was a notable trend with substrate type having a significant influence (P<0.05) on the community structure. Seaweed communities were dominated by Plocamium corallorhiza and coralline turf based on substrate types. There was also a significant relationship (P<0.05) between substrate type, dominant seaweed species and abalone presence. A Canonical Correspondence Analysis (CCA) of the community data suggested that the benthic community does not change significantly along the distance of coastline sampled. A hierarchical cluster analysis of Bray-Curtis dissimilarity for transect data also suggested that the four sites do not represent ecologically dissimilar communities. A similar analysis showed that abalone seeding had to date not altered the benthic community in shallow seeded areas from the community described for shallow unseeded areas. The study was used to describe the baseline benthic community in areas west of Cape Recife, examine the natural variability along the coast, and determine whether there are relationships between the benthic community composition and emergent abalone abundance. This information will be useful in selection of habitats for abalone seeding in the future. It is important that monitoring and surveying of the study area are to be continued in so allowing for long term data collection which will help in making informed decisions as well as documenting the impact in seeded areas when compared to unseeded areas.]]> Tue 12 Mar 2024 15:12:54 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10331 Thu 13 May 2021 16:30:28 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:29743 Thu 13 May 2021 16:09:25 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10369 Thu 13 May 2021 14:50:54 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:31629 Thu 13 May 2021 14:14:04 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:30786 Thu 13 May 2021 13:38:18 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:20677 Thu 13 May 2021 13:21:29 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:29284 Thu 13 May 2021 13:20:37 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:30647 Thu 13 May 2021 13:17:33 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:11068 Thu 13 May 2021 13:12:29 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:36926 Thu 13 May 2021 12:45:50 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:20674 Thu 13 May 2021 12:45:08 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10601 Thu 13 May 2021 12:05:21 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10588 Thu 13 May 2021 11:29:56 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10430 Thu 13 May 2021 11:17:38 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10309 Thu 13 May 2021 10:44:30 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10962 Thu 13 May 2021 10:21:05 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:32754 Thu 13 May 2021 10:04:34 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:11096 Thu 13 May 2021 09:44:54 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:26423 Thu 13 May 2021 08:53:16 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:26827 Thu 13 May 2021 08:53:07 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:27007 0.03 ha), had a higher salinity (oligohaline, mesohaline and polyhaline conditions) and a constant water body. Micro-outlets were smaller (< 0.03 ha), had a lower salinity (oligohaline conditions were most common) and showed periods of drying. Five micro-estuaries (Shelbertsstroom, Kwesani, Cunge, Mtwendwe and Mtendwe) and five micro-outlets (Stromatolite, Sandy Bottom, Ichabana, Palm Tree and Black Rock) were classified. This study has shown that the micro-estuaries along the Eastern Cape coast are pristine (i.e. intact riparian zone and catchment), untouched and highly dynamic systems (i.e. great variation in water surface area and mouth condition) highlighting their need for protection.]]> Thu 13 May 2021 08:51:18 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10532 Thu 13 May 2021 08:50:32 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:37048 Thu 13 May 2021 08:47:30 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:26876 Thu 13 May 2021 08:46:45 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10314 Thu 13 May 2021 08:46:41 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10351 Thu 13 May 2021 08:46:20 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10963 Thu 13 May 2021 08:45:51 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10313 Thu 13 May 2021 08:44:42 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:38918 Thu 13 May 2021 08:25:28 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10329 Thu 13 May 2021 08:22:46 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:32396 80 mm) showed a greater component of invertebrates in previously unexplored habitats, which proves their omnivorous diet related to ontogenetic niche use. Knowledge of fine-scale habitat use by fishes is essential for conservation planning as exclusion zones can be optimised to limit anthropogenic influence on nursery use patterns in fishes. The availability of shallow water habitats (<60 cm) was assessed as an additional driver to explain the species diversity and richness of juvenile fishes within the lower reaches. These habitats are known as important nursery habitats providing numerous marine and estuarine spawned fishes with adequate refuge and food supply. This shallow water volume was measured by means of a two-man kayak using both the spring high and low tides in the lower reaches of these systems to assess juvenile assemblages. It was clear from the results that aquatic vegetation significantly adds to the volume of these areas and as a result, much greater fish density and species richness were observed. Generalized additive models showed that marine spawned species were particularly reliant on the availability of this shallow water along with submerged vegetation and additional environmental variables. The presence of structurally submerged vegetation typically characterized within shallow estuarine waters is commonly believed to reduce predation risk resulting in elevated densities of biota. Based on the current stock status and percentage of pristine breeding stock, five fish species classified as collapsed/overexploited was consistently found within these systems with an additional 14 species currently classified as exploited/vulnerable. Based on the current species richness and diversity, available habitat cover and knowledge regarding important recreational species, priority areas that require some form of legal protection in order to meet potential biodiversity targets, could be identified. It is a legal requirement in South Africa that all estuaries require management plans that should be based on good knowledge of priority habitats for fauna and flora. The identification of estuarine protected areas is seen as a mechanism for protecting a representative sample of the biodiversity accompanied by a complete range of environmental gradients and habitat types at a reasonable scale in order to maximize the protection of estuarine species.]]> Thu 13 May 2021 08:20:19 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:27888 Thu 13 May 2021 08:19:50 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10978 Thu 13 May 2021 08:18:25 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:38165 Thu 13 May 2021 08:18:02 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10330 Thu 13 May 2021 08:17:59 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10680 Thu 13 May 2021 08:17:23 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:33034 Thu 13 May 2021 08:16:52 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10710 Thu 13 May 2021 08:16:34 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10528 Thu 13 May 2021 08:14:43 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10394 Thu 13 May 2021 08:12:30 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10758 Thu 13 May 2021 08:12:21 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:36224 Thu 13 May 2021 08:11:00 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10753 Thu 13 May 2021 08:10:18 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:39749 Thu 13 May 2021 08:08:19 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10705 Thu 13 May 2021 08:07:11 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10515 Thu 13 May 2021 08:05:29 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:28215 Thu 13 May 2021 08:04:53 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10511 Thu 13 May 2021 07:43:59 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:30801 Thu 13 May 2021 07:39:54 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10732 Thu 13 May 2021 07:38:24 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:29713 Thu 13 May 2021 07:38:23 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:26960 Thu 13 May 2021 07:38:12 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:31581 Thu 13 May 2021 07:38:01 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:29967 70%), silt (>15%) and clay (<10%). The aim of this study was to provide insight on the effects of salinity and inundation on the morphology and physiology of D. crassifolium occurring in the salt marsh terrestrial boundary and to assess its spatial and temporal changes over time. The research suggests that D. crassifolium is more sensitive to inundation than salinity. Furthermore the succulent was found in the field to be dominant in conditions which the glasshouse experiments showed to be its optimum growth. That is, in dry sediments with salinity of < 18 ppt. Therefore, if these conditions change (sediment moisture and salinity), the cover abundance of D. crassifolium could significantly change in the field.]]> Thu 13 May 2021 07:37:20 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:36485 Thu 13 May 2021 07:36:24 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10339 Thu 13 May 2021 07:36:07 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10636 20 μg l-1) was found. Different groups of microalgae formed phytoplankton blooms for the different sampling sessions, which were correlated with high chlorophyll a. These included blooms of green algae (August 2006), flagellates (March 2007), dinoflagellates (June 2008) and diatom species (February and August 2008). The dominant diatom (Cyclotella atomus) indicated nutrient-rich conditions. Green algae and diatoms were associated with low salinity water in the upper reaches of the estuary. Flagellates were dominant throughout the estuary particularly when nutrients were low, whereas the dinoflagellate bloom in June 2008 was correlated with high ammonium and pH. Maximum benthic chlorophyll a was found at 12.5 km from the mouth in February, June and August 2008 and was correlated with high sediment organic and moisture content. Benthic diatoms were associated with high temperature whereas some species in June 2008 were associated with high ammonium concentrations. The middle reaches of the estuary characterise a zone of deposition rather than suspension which would favour benthic diatom colonization. Phytoplankton cells settling out on the sediments may account for the high benthic chlorophyll a because maximum water column chlorophyll a was also found in the REI zone (where salinity is less than 10 percent and where high biological activity occurs) in the Sundays Estuary.]]> Thu 13 May 2021 07:34:22 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10637 7 days) but could survive submergence of short duration (< 7 days) through continuous underwater photosynthesis, accumulation of osmolytes such as oxalic acid and carotenoid, and maintenance of relative water content and succulence within control levels. When considered together, results showed that the two upper intertidal species were sensitive to waterlogging and would not survive complete submergence, whereas the lower intertidal species could in addition to its natural range, thrive in conditions typical of the upper intertidal range, namely prolonged dry conditions and high sediment salinity. These results have important implications for the future management of salt marshes under predicted climate change conditions. In permanently open South African estuaries, a landward migration of salt marsh will be possible if coastal squeeze is limited and the rate of landward recruitment is on par with sea level rise. In this case salt marsh species would retain their current zonation while shifting inland. Increased sea storms and saltwater intrusion could lead to high salinity concentration in the sediment and significantly reduce growth of salt-sensitive plants. In estuaries that are temporarily open to the sea, reduced freshwater inflow will result in an increase in mouth closure, high water levels, prolonged submergence, and consequently die back of salt marsh vegetation. On the other hand increased abstraction and drought would result in low water levels and high sediment salinity which would decrease growth and survival of salt marsh. This research has provided new knowledge on the ecophysiology of salt marsh plants which can be used to predict the responses of plants to climate change.]]> Thu 13 May 2021 07:33:25 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:20872 Thu 13 May 2021 07:33:01 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10736 Thu 13 May 2021 07:32:00 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10360 Thu 13 May 2021 07:31:25 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:35989 Thu 13 May 2021 07:31:09 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:35965 Thu 13 May 2021 07:30:57 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:40525 Thu 08 Jul 2021 11:35:44 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10569 Mon 23 Aug 2021 09:49:32 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:37113 Mon 22 Aug 2022 15:05:57 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:37114 Mon 22 Aug 2022 15:05:56 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:29314 Mon 22 Aug 2022 14:58:54 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:37128 Mon 22 Aug 2022 14:58:53 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:36669 Fri 15 Mar 2024 13:06:48 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:27018 Fri 15 Mar 2024 12:32:30 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:30543 Fri 15 Mar 2024 12:32:16 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:40457 Fri 15 Mar 2024 12:25:35 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:27011 Fri 15 Mar 2024 12:25:14 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:40468 Fri 15 Mar 2024 12:24:52 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:41607 Fri 15 Mar 2024 12:11:18 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:37087 1, antagonism, respectively. Most combination treatments showed to have an antagonistic effect except for cisplatin:BC-7 (1:3, 1:1, 2:1, 3:1) and cisplatin:A. afra (1:3, 1:2, 1:1, 3:1) combinations that showed synergism. The 1:2 ratio of cisplatin:BC-7 and the 2:1 ratio of cisplatin:A. afra were additive. CI values were also calculated at inhibition of 10, 25 and 75% of HeLa cell growth, for each combination mixture. Antagonistic effects were frequently observed at lower effect levels such as at 10 and 25% inhibition of growth. However, this was not seen for the cisplatin:BC-7 combinations as all the ratios indicated synergism. Some of these ratios, such as the 1:3 and 1:2, even led to a greater degree of synergism being obtained, with noticeable antagonistic effects seen at 50 and 75% inhibition of growth. The current finding is that BC-7 and A. afra could lower the dose of cisplatin in combination to achieve a similar anti-cancer efficacy compared to the higher cisplatin dose when used alone. The lower dosage in combination could result in reduced drug resistance as well as limit the toxicity on normal cells associated with cisplatin treatment. In conclusion, this study shows, for the first time, that A. nemorosa has the potential to induce apoptosis and also has some anti- and pro-inflammatory activity in HeLa cancer cells. This study also enhanced the knowledge of the mechanism of apoptosis induction of BC-7, in a more detailed manner, as well as investigated its inflammatory effects for the first time. Results obtained for A. afra correlated nicely to previously reported studies and confirmed that the methods used in this study, although different, leads to the same conclusions. Combination treatments also indicated, for the first time, that BC-7 and A. afra have the ability to function in a synergic manner with cisplatin and proves that, although extensive research may have been done on a plant or compound, more can be discovered. This new information can lead to identification of new compounds in the plants and the integration of signalling pathways that can be targeted for treatment of cancer.]]> Fri 15 Mar 2024 11:56:53 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:37837 Fri 15 Mar 2024 09:30:02 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:33371 Fri 15 Mar 2024 09:15:47 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:28280 Fri 15 Mar 2024 08:55:07 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:27098 Fri 03 Dec 2021 15:47:49 SAST ]]>