https://vital.seals.ac.za/vital/access/manager/Index en-us 5 Inhibitor search and variant analysis of Acetylcholinesterase https://vital.seals.ac.za/vital/access/manager/Repository/vital:42919 Wed 26 May 2021 15:20:13 SAST ]]> Biotechnology from bench to market: the design, scale-up and commercialisation strategy development of a disruptive bioprocess for potable ethanol production https://vital.seals.ac.za/vital/access/manager/Repository/vital:26750 Wed 20 Jul 2022 08:42:27 SAST ]]> Investigating assay formats for screening malaria Hsp90-Hop interaction inhibitors https://vital.seals.ac.za/vital/access/manager/Repository/vital:28395 Wed 12 May 2021 23:59:53 SAST ]]> Isolation, identification and genetic characterisation of a microsporidium isolated from the carob moth, Ectomyelois ceratoniae (Lepidoptera: Pyralidae) https://vital.seals.ac.za/vital/access/manager/Repository/vital:28075 Wed 12 May 2021 23:29:16 SAST ]]> The development of biodegradable aerogel scaffolds for the generation of vascularised 3D adipose tissue models https://vital.seals.ac.za/vital/access/manager/Repository/vital:27492 Wed 12 May 2021 23:07:32 SAST ]]> The effect of GH family affiliations of mannanolytic enzymes on their synergistic associations during the hydrolysis of mannan-containing substrates https://vital.seals.ac.za/vital/access/manager/Repository/vital:4148 Wed 12 May 2021 22:47:13 SAST ]]> Preliminary investigation of the molecular pathogenicity determinants of Xanthomonas campestris pv. zeae https://vital.seals.ac.za/vital/access/manager/Repository/vital:4066 Wed 12 May 2021 22:37:55 SAST ]]> The pineal gland as a model to elucidate the primary mode of action of sympathoactive agents https://vital.seals.ac.za/vital/access/manager/Repository/vital:3876 Wed 12 May 2021 22:31:12 SAST ]]> Comparative localization studies of P.falciparum ADP-ribosylation factor proteins in P.falciparum parasites and hela cells using GFP tagged constructs https://vital.seals.ac.za/vital/access/manager/Repository/vital:20519 Wed 12 May 2021 22:26:56 SAST ]]> Cyclooxygenase-1 as an anti-stroke target: potential inhibitor identification and non-synonymous single nucleotide polymorphism analysis https://vital.seals.ac.za/vital/access/manager/Repository/vital:38243 Wed 12 May 2021 20:52:22 SAST ]]> Thermophilic lignin degrading enzymes from actinomycetes for biotechnological applications https://vital.seals.ac.za/vital/access/manager/Repository/vital:4085 Wed 12 May 2021 20:21:15 SAST ]]> Investigating the use of Arbuscular Mycorrhizas and Plant Growth Promoting Bacteria to improve the drought tolerance of maize (Zea mays L.) https://vital.seals.ac.za/vital/access/manager/Repository/vital:26591 Wed 12 May 2021 20:00:07 SAST ]]> Studies on an autolysin produced by clostridium acetobutylicum https://vital.seals.ac.za/vital/access/manager/Repository/vital:3893 Wed 12 May 2021 19:43:56 SAST ]]> Targeting allosteric sites of Escherichia coli heat shock protein 70 for antibiotic development https://vital.seals.ac.za/vital/access/manager/Repository/vital:34287 Wed 12 May 2021 19:13:05 SAST ]]> An investigation into the synergistic action of cellulose-degrading enzymes on complex substrates https://vital.seals.ac.za/vital/access/manager/Repository/vital:4154 Wed 12 May 2021 19:07:50 SAST ]]> Investigating soil microbial interactions of Portulacaria afra https://vital.seals.ac.za/vital/access/manager/Repository/vital:26592 Wed 12 May 2021 19:00:54 SAST ]]> Biochemical characterization of the β-mannanase activity of Bacillus paralicheniformis SVD1 https://vital.seals.ac.za/vital/access/manager/Repository/vital:29112 Wed 12 May 2021 18:53:14 SAST ]]> Comparison of protein binding microarray derived and ChIP-seq derived transcription factor binding DNA motifs https://vital.seals.ac.za/vital/access/manager/Repository/vital:4146 Wed 12 May 2021 18:41:14 SAST ]]> An in-silico investigation of Morita-Baylis-Hillman accessible heterocyclic analogues for applications as novel HIV-1 C protease inhibitors https://vital.seals.ac.za/vital/access/manager/Repository/vital:4152 Wed 12 May 2021 18:36:22 SAST ]]> The independent high rate algal pond as a unit operation in tertiary wastewater treatment https://vital.seals.ac.za/vital/access/manager/Repository/vital:4092 Wed 12 May 2021 18:30:08 SAST ]]> Identification of potential novel roles for Hsp70/Hsp90 organising protein (Hop) using proteomic analysis in human cells https://vital.seals.ac.za/vital/access/manager/Repository/vital:28598 Wed 12 May 2021 18:27:23 SAST ]]> Comparative analysis of existing pipelines for assessment of arbuscular mycorrhizal fungal biodiversity in natural and commercial rooibos (aspalathus linearis) and honeybush (cyclopia intermedia) soil samples https://vital.seals.ac.za/vital/access/manager/Repository/vital:20342 Wed 12 May 2021 18:22:41 SAST ]]> In silico characterization of plasmodial transketolases as potential malaria drug target https://vital.seals.ac.za/vital/access/manager/Repository/vital:28433 Wed 12 May 2021 17:54:50 SAST ]]> Identification of novel SNPSTRs by 454 sequencing in Nguni and Sotho-Tswana populations https://vital.seals.ac.za/vital/access/manager/Repository/vital:26752 Wed 12 May 2021 17:42:52 SAST ]]> Comparative study of the effect of silver nanoparticles on the hexokinase activity from human and Trypanosoma brucei https://vital.seals.ac.za/vital/access/manager/Repository/vital:4149 Wed 12 May 2021 17:35:42 SAST ]]> Investigation into the influence of an alien plant species on the soil microbiota of the sub-Antarctic, Marion Island https://vital.seals.ac.za/vital/access/manager/Repository/vital:35531 Wed 12 May 2021 17:18:32 SAST ]]> Evaluation of SNPs of G6PD, with regard to the 3D conformational, structural and stability alterations, in order to investigate the clinical implications and potential applications https://vital.seals.ac.za/vital/access/manager/Repository/vital:30574 Wed 12 May 2021 17:08:20 SAST ]]> The effect of extracellular Hsp90β and TGF-β1 on colon cancer biology https://vital.seals.ac.za/vital/access/manager/Repository/vital:26753 Wed 12 May 2021 16:45:09 SAST ]]> In silico analysis of plasmodium falciparum Hsp70-x for potential binding sites and hits https://vital.seals.ac.za/vital/access/manager/Repository/vital:27435 Wed 12 May 2021 16:40:58 SAST ]]> The development of biological tools to aid in the genetic investigation of the black (Diceros bicornis) and white (Ceratotherium simum) rhinoceros mitochondrial genomes https://vital.seals.ac.za/vital/access/manager/Repository/vital:26769 Wed 12 May 2021 16:25:40 SAST ]]> Arbuscular mycorrhizal fungi as a bio-indicator of soil health under agricultural management practices in South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:30011 Wed 12 May 2021 16:12:08 SAST ]]> Development of a high-throughput bioassay to determine the rate of antimalarial drug action using fluorescent vitality probes https://vital.seals.ac.za/vital/access/manager/Repository/vital:28542 Wed 12 May 2021 16:09:18 SAST ]]> Bio-prospecting a Soil Metagenomic Library for Carbohydrate Active Esterases https://vital.seals.ac.za/vital/access/manager/Repository/vital:4172 Wed 12 May 2021 16:06:18 SAST ]]> Genetic and biological characterisation of a novel South African Cydia pomonella granulovirus (CpGV-SA) isolate https://vital.seals.ac.za/vital/access/manager/Repository/vital:20503 Wed 12 May 2021 16:03:21 SAST ]]> Identification of SNPs within the CYP2A6 enzyme of TNBC cell lines and the resulting change in activity https://vital.seals.ac.za/vital/access/manager/Repository/vital:28536 Wed 12 May 2021 15:52:54 SAST ]]> The development of high-throughput assays to screen for potential anticancer and antimalarial compounds that target ADP-ribosylation factor 6 and its signalling machineries https://vital.seals.ac.za/vital/access/manager/Repository/vital:30810 Wed 12 May 2021 15:50:08 SAST ]]> Comparative study of clan CA cysteine proteases: an insight into the protozoan parasites https://vital.seals.ac.za/vital/access/manager/Repository/vital:4165 Wed 12 May 2021 15:45:50 SAST ]]> Analysis of the regulation of HSP90α expression upon differentiation of C2C12 cells https://vital.seals.ac.za/vital/access/manager/Repository/vital:41028 Wed 12 May 2021 15:08:19 SAST ]]> Structure and interaction studies of beta-amyloid in the search for new lead compounds for the treatment of Alzheimer’s disease https://vital.seals.ac.za/vital/access/manager/Repository/vital:41493 Wed 12 May 2021 15:00:41 SAST ]]> Selection for improved virulence of Cryptophlebia peltastica nucleopolyhedrovirus (CrpeNPV) to False Codling Moth, Thaumatotibia leucotreta, by serial passage through a heterologous host https://vital.seals.ac.za/vital/access/manager/Repository/vital:42918 Wed 12 May 2021 14:59:28 SAST ]]> The exploration of ARF1 screening assays to determine the drug status of ARF1 in cancer and malaria https://vital.seals.ac.za/vital/access/manager/Repository/vital:41458 0.5, suggesting that further development of the assay format to identify GEF and GAP inhibitors may be feasible. In the case of the colorimetric assay, robust signals could be detected and the assay was useful for detecting the activation status of ARF1. However, although the activation of ARF1 by the Sec7 domains of the BIG1 and ARNO was detectable, signals were not robust enough to employ in screening campaigns.]]> Wed 12 May 2021 14:25:48 SAST ]]> Prediction of mass spectra for natural products using an ab initio approach https://vital.seals.ac.za/vital/access/manager/Repository/vital:41443 Wed 12 May 2021 14:21:40 SAST ]]> Production, purification and characterization of a multifunctional, thermostable and acido/alkaline stable putative xylanase from the psychrotrophic bacterium, Sphingomonas aerolata https://vital.seals.ac.za/vital/access/manager/Repository/vital:41122 Wed 12 May 2021 14:09:28 SAST ]]> Characterization of the diversity and metabolic potential of hypolithic communities in dronning Maud Land, Antarctica https://vital.seals.ac.za/vital/access/manager/Repository/vital:42944 Wed 12 May 2021 14:03:03 SAST ]]> Evaluation of an NADPH-dependent assay for inhibition screening of Salmonella enterica DOXP Reguctoisomerase for identification of novel drug hit compounds https://vital.seals.ac.za/vital/access/manager/Repository/vital:41440 Wed 12 May 2021 13:53:32 SAST ]]> In silico identification of selective novel hits against the active site of wild type mycobacterium tuberculosis pyrazinamidase and its mutants https://vital.seals.ac.za/vital/access/manager/Repository/vital:42898 Wed 12 May 2021 13:51:19 SAST ]]> Investigating the relationship between Heat Shock Proteins and HIV Transactivator of Transcription https://vital.seals.ac.za/vital/access/manager/Repository/vital:41027 Wed 12 May 2021 13:50:39 SAST ]]> Alternative approach to controlling citrus black spot disease https://vital.seals.ac.za/vital/access/manager/Repository/vital:42951 Wed 12 May 2021 13:46:56 SAST ]]> The isolation, genetic characterisation and biological activity of a South African Phthorimaea operculella granulovirus (PhopGV-SA) for the control of the Potato Tuber Moth, Phthorimaea operculella (Zeller) https://vital.seals.ac.za/vital/access/manager/Repository/vital:4147 Tue 15 Aug 2023 11:05:20 SAST ]]> Investigation of the causative agents of the 1982 Gazankulu poliomyelitis outbreak, using four biochemical techniques https://vital.seals.ac.za/vital/access/manager/Repository/vital:3878 Thu 13 May 2021 10:53:07 SAST ]]> Isolation, expression and purification of the hydantoin hydrolysing enzymes of agrobacterium tumefaciens https://vital.seals.ac.za/vital/access/manager/Repository/vital:4140 Thu 13 May 2021 09:31:13 SAST ]]> Analysis of predictive power of binding affinity of PBM-derived sequences https://vital.seals.ac.za/vital/access/manager/Repository/vital:4161 Thu 13 May 2021 08:18:59 SAST ]]> In silico analysis of the effects of non-synonymous single nucleotide polymorphisms on the human macrophage migration inhibitory factor gene and their possible role in human African trypanosomiasis susceptibility https://vital.seals.ac.za/vital/access/manager/Repository/vital:20355 Thu 13 May 2021 08:11:45 SAST ]]> In silico study of Plasmodium 1-deoxy-dxylulose 5-phosphate reductoisomerase (DXR) for identification of novel inhibitors from SANCDB https://vital.seals.ac.za/vital/access/manager/Repository/vital:28523 Thu 13 May 2021 07:20:26 SAST ]]> Nanofiber immobilized cellulases and hemicellulases for fruit waste beneficiation https://vital.seals.ac.za/vital/access/manager/Repository/vital:4153 Thu 13 May 2021 07:14:07 SAST ]]> Chitin hydrolysis with chitinolytic enzymes for the production of chitooligomers with antimicrobial properties https://vital.seals.ac.za/vital/access/manager/Repository/vital:29165 Thu 13 May 2021 07:11:47 SAST ]]> The development of an immobilised-enzyme bioprobe for the detection of phenolic pollutants in water https://vital.seals.ac.za/vital/access/manager/Repository/vital:4069 Thu 13 May 2021 07:10:21 SAST ]]> Recovery and molecular identification of Aichi virus 1, enteric human bocaviruses and enteric human adenoviruses in untreated sewage and mussel samples collected in the Eastern Cape Province of South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:29539 Thu 13 May 2021 06:24:12 SAST ]]> Synthesis of silver nanoparticles and their role against human and Plasmodium falciparum leucine aminopeptidase https://vital.seals.ac.za/vital/access/manager/Repository/vital:4150 Thu 13 May 2021 06:17:59 SAST ]]> Prediction of interacting motifs within the protein subunits of Picornavirus capsids https://vital.seals.ac.za/vital/access/manager/Repository/vital:4151 Thu 13 May 2021 06:08:57 SAST ]]> The pineal gland as a model to elucidate the primary mode of action of sympathoactive agents https://vital.seals.ac.za/vital/access/manager/Repository/vital:4279 Thu 13 May 2021 05:55:08 SAST ]]> Development and evaluation of a web application employing artificial neural networks to facilitate the prediction of antiretroviral drug resistance in patients infected with HIV-1 subtype B https://vital.seals.ac.za/vital/access/manager/Repository/vital:28406 Thu 13 May 2021 05:46:15 SAST ]]> Molecular cloning and expression of equine CYP1A2 in Escherichia coli https://vital.seals.ac.za/vital/access/manager/Repository/vital:20734 Thu 13 May 2021 05:08:47 SAST ]]> Molecular simulations of potential agents and targets of Alzheimer’s disease https://vital.seals.ac.za/vital/access/manager/Repository/vital:37825 Thu 13 May 2021 04:44:54 SAST ]]> The Rhodes BioSure process in the treatment of acid mine drainage wastewaters https://vital.seals.ac.za/vital/access/manager/Repository/vital:4077 Thu 13 May 2021 04:40:54 SAST ]]> Localizing selected endocytosis protein candidates in Plasmodium falciparum using GFP-tagged fusion constructs https://vital.seals.ac.za/vital/access/manager/Repository/vital:20316 Thu 13 May 2021 04:32:33 SAST ]]> Changes in the aerobic saprophytic microbial flora during biltong production with special reference to the micrococcaceae https://vital.seals.ac.za/vital/access/manager/Repository/vital:4120 Thu 13 May 2021 04:30:31 SAST ]]> A case-control approach to assess variability in distribution of distance between transcription factor binding site and transcription start site https://vital.seals.ac.za/vital/access/manager/Repository/vital:20808 Thu 13 May 2021 04:26:39 SAST ]]> In silico analysis of human Hsp90 for the identification of novel anti-cancer drug target sites and natural compound inhibitors https://vital.seals.ac.za/vital/access/manager/Repository/vital:4162 Thu 13 May 2021 04:21:21 SAST ]]> Structural analysis of proteases from South African HIV-1 (subtype C) patients undergoing Lopinavir treatment, using comparative modeling, ligand-docking and molecular dynamics https://vital.seals.ac.za/vital/access/manager/Repository/vital:20744 Thu 13 May 2021 03:51:11 SAST ]]> Using bioinformatics tools to screen for trypanosomal cathepsin B cysteine protease inhibitors from the SANCDB as a novel therapeutic modality against Human African Trypanosomiasis (HAT) https://vital.seals.ac.za/vital/access/manager/Repository/vital:20470 Thu 13 May 2021 02:38:32 SAST ]]> The relationship between OCT4 and an aggressive phenotype in triple negative breast cancer (TNBC) https://vital.seals.ac.za/vital/access/manager/Repository/vital:27477 Thu 13 May 2021 02:25:16 SAST ]]> Characterisation of the HSP70-HSP90 organising protein gene and its link to cancer https://vital.seals.ac.za/vital/access/manager/Repository/vital:26764 Thu 13 May 2021 02:18:22 SAST ]]> The development of techniques for the identification of novel viruses associated with acute infantile gastroenteritis in South Africa https://vital.seals.ac.za/vital/access/manager/Repository/vital:24725 Thu 13 May 2021 01:59:17 SAST ]]> Biological properties and interactions of Kalaharituber pfeilii https://vital.seals.ac.za/vital/access/manager/Repository/vital:30022 Thu 13 May 2021 01:46:09 SAST ]]> Citizen science, treatment and microbial compliance monitoring in rainwater harvesting in Namibia https://vital.seals.ac.za/vital/access/manager/Repository/vital:28105 Thu 13 May 2021 01:32:49 SAST ]]> An investigation into the potential immunogenicity of various extracts of the South African bont tick Amblyomma hebraeum https://vital.seals.ac.za/vital/access/manager/Repository/vital:4127 Thu 13 May 2021 01:14:51 SAST ]]> Regulation of cell biology by extracellular species of the Hsp90- Hsp70 organising protein (Hop) https://vital.seals.ac.za/vital/access/manager/Repository/vital:27465 Thu 13 May 2021 00:47:31 SAST ]]> Development and optimisation of a novel Plasmodium falciparum Hsp90-Hop interaction assay https://vital.seals.ac.za/vital/access/manager/Repository/vital:28216 Thu 01 Jun 2023 09:58:06 SAST ]]>