https://vital.seals.ac.za/vital/access/manager/Index en-us 5 https://vital.seals.ac.za/vital/access/manager/Repository/vital:8209 Wed 13 Mar 2024 11:27:17 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10312 Wed 12 May 2021 23:42:04 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10167 Wed 12 May 2021 23:30:46 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10030 Wed 12 May 2021 23:14:22 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8181 Wed 12 May 2021 23:11:54 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9482 Wed 12 May 2021 22:57:59 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8390 Wed 12 May 2021 22:54:46 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8643 Wed 12 May 2021 22:20:03 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10423 Wed 12 May 2021 22:17:41 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8165 Wed 12 May 2021 20:31:04 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10464 Wed 12 May 2021 20:31:02 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10504 Wed 12 May 2021 20:21:45 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:16128 Wed 12 May 2021 20:19:09 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8948 Wed 12 May 2021 20:13:51 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9506 Wed 12 May 2021 20:10:25 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10220 Wed 12 May 2021 20:04:53 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9039 Wed 12 May 2021 19:41:26 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8185 Wed 12 May 2021 19:19:12 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8653 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https://vital.seals.ac.za/vital/access/manager/Repository/vital:8957 Wed 12 May 2021 18:12:20 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9686 Wed 12 May 2021 17:56:42 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8361 Wed 12 May 2021 17:54:10 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8195 Wed 12 May 2021 17:53:22 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8200 Wed 12 May 2021 17:47:42 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9356 Wed 12 May 2021 17:45:32 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10465 Wed 12 May 2021 17:26:49 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9075 Wed 12 May 2021 17:14:11 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:16142 Wed 12 May 2021 17:08:49 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9729 Wed 12 May 2021 17:05:22 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8193 Wed 12 May 2021 16:53:25 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9887 Wed 12 May 2021 16:52:45 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8180 Wed 12 May 2021 16:49:31 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8391 Wed 12 May 2021 16:44:38 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9401 Wed 12 May 2021 16:32:15 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8191 Wed 12 May 2021 16:28:15 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8656 Wed 12 May 2021 16:12:34 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8679 Wed 12 May 2021 16:00:17 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8456 Wed 12 May 2021 15:50:56 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10141 Wed 12 May 2021 15:46:33 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10746 Wed 12 May 2021 15:45:41 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10311 Wed 12 May 2021 15:44:28 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9896 Thu 13 May 2021 07:24:58 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10462 Thu 13 May 2021 07:20:59 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9861 Thu 13 May 2021 07:15:18 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10130 Thu 13 May 2021 07:12:51 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9746 Thu 13 May 2021 07:09:04 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10338 Thu 13 May 2021 07:01:58 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8650 Thu 13 May 2021 07:01:44 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8389 Thu 13 May 2021 06:54:42 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8506 Thu 13 May 2021 06:43:34 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8208 Thu 13 May 2021 06:42:12 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9629 75 percent joint efficiency). High Vickers microhardness values were measured at the joint interfaces, which corresponded with the intermetallic compounds. The Energy Dispersive Spectroscopy analysis revealed the presence of thin layers of intermetallics in nanoscale at the interfacial regions. The diffractograms of the X-Ray Diffraction analysis showed small peaks for intermetallics in some of the welds. Low electrical resistivities were measured at the joint interfaces. The statistical analysis showed that the downward vertical force, (Fz) can significantly influence the resulting weld qualities. An overall summary of the analysis of the weld qualities - with respect to the shoulder diameter tools employed showed that the 18 mm shoulder diameter tool is most appropriate among the three shoulder diameters considered, and a process window of medium spindle speed of 950 rpm and low-to-medium feed rate between 50 and 150 mm/min is established for FSW of Aluminium and Copper. Welds produced at 1200 rpm and 300 mm/min with low heat input did not have intermetallics formed at the joint interface.]]> Thu 13 May 2021 06:36:12 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10277 Thu 13 May 2021 06:30:28 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9994 Thu 13 May 2021 06:22:51 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10120 Thu 13 May 2021 06:15:44 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8202 Thu 13 May 2021 06:09:13 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10321 sCD23>derCD23) for IgE, upon increasing length of the proximal CD23 “stalk” domain. These findings highlight the differences in both the structural basis and affinity of the three physiological fragments of human CD23 for the ligands CD21 and IgE and underscore the complexity of CD23-mediated regulatory networks. It was found that B-cells only make up ~5% of the PBMC population, and that these cells were able to be activated, via STAT-6 phosphorylation, to enter class switch recombination (CSR) by the addition of switch factors (IL-4 and anti-CD40). Titration experiments dictated that 25 ng/mL of CD23 was the most efficient concentration to up-regulate IgE synthesis in PBMCs; furthermore, soluble CD23 proteins were incubated with PBMCs in the presence and absence of CD21 SCR 1-2 to investigate the effect that these recombinant proteins have on IgE synthesis. Results showed that the influence of recombinant proteins (both CD23 and CD21) on IgE synthesis was slight. It was shown that while derCD23 had no significant effect, monomeric sCD23 down-regulated, and the mixture of monomeric and oligomeric exCD23 up-regulated IgE synthesis. On addition of CD21 SCR 1-2 to the cells switched and treated with soluble CD23, it was found that in both cases for sCD23 and exCD23, IgE synthesis was increased, while for derCD23, there was no noticeable difference in IgE synthesis. This confirmed previous data showing the lack of binding between derCD23 and CD21 SCR 1-2. The exact binding site for CD21 on the CD23 molecule is unknown, and incompletely represented in the NMR and crystal structures. It is thought that CD21 binds to the C-terminal tail section, not present in derCD23. It is therefore likely that only a negative-feedback mechanism operates with derCD23 to regulate IgE synthesis. Further investigation of the binding of CD23 fragments to SCR 5-8 of CD21 and the effect of this on IgE synthesis may lead to a potential therapeutic role for derCD23 in the treatment of allergic disease. Data accumulated in this study suggests that investigating the modulation of oligomeric state and thus the activity of soluble CD23 fragments may be important in the construction of new regulators of IgE synthesis.]]> Thu 13 May 2021 05:44:14 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8201 Thu 13 May 2021 05:23:21 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9285 Thu 13 May 2021 05:13:38 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8630 Thu 13 May 2021 05:04:02 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9341 Thu 13 May 2021 04:41:25 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8981 Thu 13 May 2021 04:39:22 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8205 Thu 13 May 2021 04:35:08 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8575 Thu 13 May 2021 04:13:27 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8207 Thu 13 May 2021 04:09:58 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9281 Thu 13 May 2021 04:08:33 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10459 Thu 13 May 2021 04:00:48 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10693 Thu 13 May 2021 04:00:03 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9874 Thu 13 May 2021 03:37:50 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8608 Thu 13 May 2021 03:34:04 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:16140 Thu 13 May 2021 03:14:23 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8694 Thu 13 May 2021 03:09:43 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8593 Thu 13 May 2021 02:59:36 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8166 Thu 13 May 2021 02:44:39 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9443 Thu 13 May 2021 02:31:03 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8600 Thu 13 May 2021 02:09:50 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8610 Thu 13 May 2021 02:02:55 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9898 Thu 13 May 2021 01:37:33 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:16139 Thu 13 May 2021 01:23:17 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10340 Thu 13 May 2021 01:22:10 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9688 Thu 13 May 2021 01:14:34 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10740 Thu 13 May 2021 01:13:53 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8662 Thu 13 May 2021 00:49:17 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10542 Thu 13 May 2021 00:41:15 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9041 Thu 13 May 2021 00:38:58 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10699 1 kg). By excluding small rodents from the analysis, prey preference could be estimated for other species and prey size categories. Small- and medium-sized mammals were significantly preferred, whereas large mammals were significantly avoided by the Cape leopard.]]> Thu 13 May 2021 00:37:40 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:8626 Thu 13 May 2021 00:26:33 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:16138 Thu 13 May 2021 00:16:36 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:9617 Thu 13 May 2021 00:15:04 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:16136 Thu 13 May 2021 00:09:34 SAST ]]> https://vital.seals.ac.za/vital/access/manager/Repository/vital:10175 Fri 15 Mar 2024 13:11:05 SAST ]]>